Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy(336 views) Ciampi Q, Betocchi S, Losi MA, Ferro A, Cuocolo A, Lombardi R, Villari B, Chiariello M
Department of Clinical Medicine, Federico II University School of Medicine, Naples, Italy.
Division of Cardiology, Fatebenefratelli Hospital, Benevento, Italy
Department of Morphological and Functional Sciences, Federico II University School of Medicine, Naples, Italy
References: Spirito, P., Seidman, C.E., McKenna, W.J., Maron, B.J., The management of hypertrophic cardiomyopathy (1997) N Engl J Med, 11, pp. 775-78
Maki, S., Ikeda, H., Muro, A., Yoshida, N., Shibata, A., Koga, Y., Predictors of sudden cardiac death in hypertrophic cardiomyopathy (1998) Am J Cardiol, 82, pp. 774-778
Counihan, P.J., Frenneaux, M.P., Webb, D.J., McKenna, W.J., Abnormal vascular response to supine exercise in hypertrophic cardiomyopathy (1991) Circulation, 84, pp. 686-696
Frenneaux, M.P., Counihan, P.J., Caforio, A.L.P., Chikamori, T., McKenna, W.J., Abnormal blood pressure response during exercise in hypertrophic cardiomyopathy (1990) Circulation, 82, pp. 1995-2002
Olivotto, I., Maron, B.J., Montereggi, A., Mazzuoli, F., Dolara, A., Cecchi, F., Prognostic value of systemic blood pressure response during exercise in a community-based patient population with hypertrophic cardiomyopathy (1999) J Am Coll Cardiol, 33, pp. 2044-2051
Sadoul, N., Prasad, K., Elliott, P.M., Bannerjee, S., Frenneaux, M.P., McKenna, W.J., Prospective assessment of blood pressure response during exercise in patients with hypertrophic cardiomyopathy (1997) Circulation, 96, pp. 2987-2991
Ciampi, Q., Betocchi, S., Lombardi, R., Losi, M.A., Manganelli, F., Storto, G., Hemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy (2002) J Am Coll Cardiol, 40, pp. 278-284
Yoshida, N., Ikeda, H., Wada, T., Matsumoto, A., Maki, S., Muro, A., Exercise-induced abnormal blood pressure response are related to subendocardial ischemia in hypertrophic cardiomyopathy (1998) J Am Coll Cardiol, 32, pp. 1938-1942
Sharma, S., Elliott, P., Whyte, G., Jones, S., Mahon, N., Whipp, B., Utility of cardiopulmonary exercise in the assessment of clinical determinants of functional capacity in hypertrophic cardiomyopathy (2000) Am J Cardiol, 86, pp. 162-168
Yamada, M., Elliott, P.M., Kaski, J.C., Prasad, K., Gane, J.N., Lowe, C.M., Dipyridamole stress thallium-201 perfusion abnormalities in patients with hypertrophic cardiomyopathy (1998) Eur Heart J, 19, pp. 500-507
Cannon III, R.O., Schenke, W.H., Maron, B.J., Tracy, C.M., Leon, M.B., Brush, J.E., Differences in coronary flow and myocardial metabolism at rest and during pacing between patients with obstructive and patients with nonobstructive hypertrophic cardiomyopathy (1987) J Am Coll Cardiol, 10, pp. 53-62
Camici, P., Chiriatti, G., Lorenzoni, R., Bellina, R.C., Gistri, R., Italiani, G., Coronary vasodilation is impaired in both hypertrophied and nonhypertrophied myocardium of patients with hypertrophic cardiomyopathy: a study with nitrogen-13 ammonia and positron emission tomography (1991) J Am Coll Cardiol, 5, pp. 879-886
Taki, J., Nakajima, K., Shimizu, M., Tonami, N., Hisada, K., Left ventricular functional reserve in nonobstructive hypertrophic cardiomyopathy: evaluation by continuous left ventricular function monitoring (1994) J Nucl Med, 35, pp. 1937-1943
Okeie, K., Shimizu, M., Yoshio, H., Ino, H., Yamaguchi, M., Matsuyama, T., Left ventricular systolic dysfunction during exercise and dobutamine stress in patients with hypertrophic cardiomyopathy (2000) J Am Coll Cardiol, 36, pp. 856-863
Wigle, E.D., Sasson, Z., Henderson, M.A., Ruddy, T.D., Fulop, J., Rakowski, H., Hypertrophic cardiomyopathy: the importance of the site and the extent of hypertrophy: a review (1985) Prog Cardiovasc Dis, 28, pp. 1-83
Maron, B.J., Epstein, S.E., Hypertrophic cardiomyopathy: a discussion of nomenclature (1979) Am J Cardiol, 43, pp. 1242-1244
O'Gara, P.T., Bonow, R.O., Maron, B.J., Damske, B.A., Van Lingen, A., Bacharach, S.L., Myocardial perfusion abnormalities in patients with hypertrophic cardiomyopathy: assessment with thallium-201 emission computed tomography (1987) Circulation, 76, pp. 1214-1223
Sahn, D.J., DeMaria, A., Kisslo, J., Weiman, A., Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements (1978) Circulation, 58, pp. 1072-1083
Spirito, P., Maron, B.J., Chiarella, F., Bellotti, P., Tramarin, R., Pozzoli, M., Diastolic abnormalities in patients with hypertrophic cardiomyopathy: relation to magnitude of left ventricular hypertrophy (1985) Circulation, 72, pp. 310-316
Spirito, P., Chiarella, M., Carratino, L., Zoni Berisso, M., Bellotti, P., Vecchio, C., Clinical course and prognosis of hypertrophic cardiomyopathy in an outpatient population (1989) N Engl J Med, 320, pp. 749-755
Helmcke, F., Nanda, N.C., Hsiung, M.C., Soto, B., Adey, C.K., Goyal, R.G., Color Doppler assessment of mitral regurgitation with orthogonal planes (1987) Circulation, 75, pp. 175-183
Panza, J.A., Petrone, R.K., Fananapazir, L., Maron, B.J., Utility of continuous wave Doppler echocardiography in the noninvasive assessment of left ventricular outflow tract pressure gradient in patients with hypertrophic cardiomyopathy (1991) J Am Coll Cardiol, 19, pp. 91-99
Betocchi, S., Piscione, F., Villari, B., Pace, L., Ciarmiello, A., Perrone-Filardi, P., Effects of induced asynchrony on left ventricular diastolic function in patients with coronary artery disease (1993) J Am Coll Cardiol, 21, pp. 1124-1131
Wilson, R.A., Sullivan, P.J., Moore, R.H., Zielonka, J.S., Alpert, N.M., Boucher, C.A., An ambulatory ventricular function monitor: validation and preliminary results (1983) Am J Cardiol, 52, pp. 601-606
Pace, L., Cuocolo, A., Nappi, A., Nicolai, E., Trimarco, B., Salvatore, M., Accuracy and repeatability of left ventricle systolic and diastolic function measurements using an ambulatory radionuclide monitor (1992) Eur J Nucl Med, 19, pp. 800-806
Bruce, R.A., McDonough, J.R., Stress testing for cardiovascular disease (1969) Bull NY Acad Med, 45, pp. 1288-1294
Wassermann, K., Hansen, J.E., Sue, D.Y., (1986) Principles of exercise testing and interpretation, p. 73. , Lea & Febiger, Philadephia
Dilsizian, V., Bonow, R.O., Epstein, S.E., Fananapazir, L., Myocardial ischemia detected by thallium scintigraphy is frequently related to cardiac arrest and syncope in young patients with hypertrophic cardiomyopathy (1993) J Am Coll Cardiol, 22, pp. 796-804
Cannon III, R.O., Rosing, D.R., Maron, B.J., Leon, M.B., Bonow, R.O., Watson, R.M., Myocardial ischemia in patients with hypertrophic cardiomyopathy: contribution of inadequate vasodilator reserve and elevated left ventricular filling pressure (1985) Circulation, 71, pp. 234-243
Tamaki, N., Yashuda, T., Moore, R.H., Gill, J.B., Boucher, C.A., Hutter, A.M., Continuous monitoring of left ventricular function by an ambulatory radionuclide detector in patients with coronary artery disease (1988) J Am Coll Cardiol, 12, pp. 669-679
Dubach, P., Froelicher, V.F., Klein, J., Oakes, D., Grover-McKay, Friis, R., Exercise-induced hypotension in a male population. Criteria, causes and prognosis (1988) Circulation, 78, pp. 1380-1387
Gibbons, R.J., Hu, D.C., Clements, I.P., Mankin, H.T., Zinsmeister, A.R., Brown, M.L., Anatomic and functional significance of hypotensive response during supine exercise radionuclide ventriculography (1987) Am J Cardiol, 60, pp. 1-4
Kim, J.J., Lee, C.W., Park, S.W., Hong, M.K., Lim, H.Y., Song, J.K., Improvement in exercise capacity and exercise blood pressure response after transcoronary alcohol ablation therapy of septal hypertrophy in hypertrophic cardiomyopathy (1999) Am J Cardiol, 83, pp. 1120-1123
Flamm, S.D., Taki, J., Moore, R., Lewis, S.F., Keech, F., Maltais, F., Redistribution of regional and organ blood volume and effect on cardiac function in elation to upright exercise intensity in healthy human subjects (1990) Circulation, 81, pp. 1550-1559
Counihan, P. J., Frenneaux, M. P., Webb, D. J., McKenna, W. J., Abnormal vascular response to supine exercise in hypertrophic cardiomyopathy (1991) Circulation, 84, pp. 686-696
Frenneaux, M. P., Counihan, P. J., Caforio, A. L. P., Chikamori, T., McKenna, W. J., Abnormal blood pressure response during exercise in hypertrophic cardiomyopathy (1990) Circulation, 82, pp. 1995-2002
Cannon III, R. O., Schenke, W. H., Maron, B. J., Tracy, C. M., Leon, M. B., Brush, J. E., Differences in coronary flow and myocardial metabolism at rest and during pacing between patients with obstructive and patients with nonobstructive hypertrophic cardiomyopathy (1987) J Am Coll Cardiol, 10, pp. 53-62
Wigle, E. D., Sasson, Z., Henderson, M. A., Ruddy, T. D., Fulop, J., Rakowski, H., Hypertrophic cardiomyopathy: the importance of the site and the extent of hypertrophy: a review (1985) Prog Cardiovasc Dis, 28, pp. 1-83
Maron, B. J., Epstein, S. E., Hypertrophic cardiomyopathy: a discussion of nomenclature (1979) Am J Cardiol, 43, pp. 1242-1244
O'Gara, P. T., Bonow, R. O., Maron, B. J., Damske, B. A., Van Lingen, A., Bacharach, S. L., Myocardial perfusion abnormalities in patients with hypertrophic cardiomyopathy: assessment with thallium-201 emission computed tomography (1987) Circulation, 76, pp. 1214-1223
Sahn, D. J., DeMaria, A., Kisslo, J., Weiman, A., Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements (1978) Circulation, 58, pp. 1072-1083
Panza, J. A., Petrone, R. K., Fananapazir, L., Maron, B. J., Utility of continuous wave Doppler echocardiography in the noninvasive assessment of left ventricular outflow tract pressure gradient in patients with hypertrophic cardiomyopathy (1991) J Am Coll Cardiol, 19, pp. 91-99
Wilson, R. A., Sullivan, P. J., Moore, R. H., Zielonka, J. S., Alpert, N. M., Boucher, C. A., An ambulatory ventricular function monitor: validation and preliminary results (1983) Am J Cardiol, 52, pp. 601-606
Bruce, R. A., McDonough, J. R., Stress testing for cardiovascular disease (1969) Bull NY Acad Med, 45, pp. 1288-1294
Jones, N. L., (1988) Clinical exercise testing, pp. 208-212. , Saunders, Philadelphia: W. B
Gibbons, R. J., Hu, D. C., Clements, I. P., Mankin, H. T., Zinsmeister, A. R., Brown, M. L., Anatomic and functional significance of hypotensive response during supine exercise radionuclide ventriculography (1987) Am J Cardiol, 60, pp. 1-4
Kim, J. J., Lee, C. W., Park, S. W., Hong, M. K., Lim, H. Y., Song, J. K., Improvement in exercise capacity and exercise blood pressure response after transcoronary alcohol ablation therapy of septal hypertrophy in hypertrophic cardiomyopathy (1999) Am J Cardiol, 83, pp. 1120-1123
Flamm, S. D., Taki, J., Moore, R., Lewis, S. F., Keech, F., Maltais, F., Redistribution of regional and organ blood volume and effect on cardiac function in elation to upright exercise intensity in healthy human subjects (1990) Circulation, 81, pp. 1550-1559
Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy
BACKGROUND: Abnormal blood-pressure response during exercise occurs in about one third of patients with hypertrophic cardiomyopathy (HCM), and it has been associated with a high risk of sudden cardiac death. We assessed the hemodynamics of exercise in HCM patients with abnormal blood-pressure response by using ambulatory radionuclide monitoring (VEST) of left-ventricular (LV) function, and exercise tolerance by oxygen consumption.; METHODS: Twenty-two HCM patients underwent treadmill exercise during VEST monitoring. A cardiopulmonary exercise test was performed a few days after. The VEST data were averaged for 1 minute. Stroke volume, cardiac output, and systemic vascular resistance were expressed as percent of baseline. Exercise tolerance was assessed as maximal oxygen consumption.; RESULTS: In eight HCM patients (36%) with an abnormal blood-pressure response, end-systolic volume increased more (52% +/- 21% vs 31% +/- 28%, P = .012), and the ejection fraction (-31% +/- 17% vs -14% +/- 22%, P = .029) and stroke volume (-21% +/- 21% vs 3% +/- 28%, P = .026) fell more, than in patients with normal response. Cardiac output increased less in the former patients (49% +/- 44% vs 94% +/- 44%, P = .012). Systemic vascular resistance decreased similarly, irrespective of blood-pressure response (-28% +/- 26% vs -34% +/- 26%, P = N.S.). Percent of maximal predicted oxygen consumption was lower in HCM patients with an abnormal blood-pressure response (63% +/- 11% vs 78% +/- 15%, P = .025).; CONCLUSIONS: In HCM patients, abnormal blood-pressure response was associated with exercise-induced LV systolic dysfunction and impairment in oxygen consumption. This may cause hemodynamic instability, associated with a high risk of sudden cardiac death.
Abnormal blood-pressure response to exercise and oxygen consumption in patients with hypertrophic cardiomyopathy
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