Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein(579 views) Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
Department of Biological Sciences, Division of Biostructures, University of Naples Federico II, Via Mezzocannone 16, 80134, Napoli, Italy.
Department of Experimental Medicine-II, University of Naples, Via De Crecchio 7, 80138, Napoli, Italy
Centro Interuniversitario di Ricerca Sui Peptidi Bioattivi, University of Naples Federico II, Via Mezzocannone 16, 80134, Napoli, Italy
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Via Mezzocannone 16, 80134, Napoli, Italy
Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QPz, United Kingdom
Department of Environmental Science-II, University of Naples, via Vivaldi 43, 81100 Caserta, Italy
References: Rey, F.A., (2006) EMBO Rep, 7, pp. 1000-100
Shukla, D., Spear, P.G., (2001) J. Clin. Investig, 108, pp. 503-510
Lai, A.L., Tamm, L.K., (2007) J. Biol. Chem, 282, pp. 23946-23956
Buzon, V., Padros, E., Cladera, J., (2005) Biochemistry, 44, pp. 13354-13364
Rey, F. A., (2006) EMBO Rep, 7, pp. 1000-100
Montgomery, R. I., Warner, M. S., Lum, B. J., Spear, P. G., (1996) Cell, 87, pp. 427-436
Geraghty, R. J., Krummenacher, C., Cohen, G. H., Eisenberg, R. J., Spear, P. G., (1998) Science, 280, pp. 1618-1620
Warner, M. S., Geraghty, R. J., Martinez, W. M., Montgomery, R. I., Whitbeck, J. C., Xu, R., Eisenberg, R. J., Spear, P. G., (1998) Virology, 246, pp. 179-189
Carf, A., Willis, S. H., Whitbeck, J. C., Krummenacher, C., Cohen, G. H., Eisenberg, R. J., Wiley, D. C., (2001) Mol. Cell, 8, pp. 169-179
Heldwein, E. E., Lou, H., Bender, F. C., Cohen, G. H., Eisenberg, R. J., Harrison, S. C., (2006) Science, 313, pp. 217-220
Spear, P. G., Manoj, S., Yoon, M., Jogger, C. R., Zago, A., Myscofski, D., (2006) Virology, 344, pp. 17-24
Gage, P. J., Levine, M., Glorioso, J. C., (1993) J. Virol, 67, pp. 2191-2201
Cairns, T. M., Landsburg, D. J., Whitbeck, J. C., Eisenberg, R. J., Cohen, G. H., (2005) Virology, 332, pp. 550-562
Cairns, T. M., Milne, R. S. B., Ponce-de-Leon, M., Tobin, D. K., Cohen, G. H., Eisenberg, R. J., (2003) J. Virol, 77, pp. 6731-6742
Wilson, D. W., Davis-Poynter, N., Minson, A. C., (1994) J. Virol, 68, pp. 6985-6993
Subramanian, R. P., Geraghty, R. J., (2007) Proc. Natl. Acad. Sci. U. S. A, 104, pp. 2903-2908
Wimley, W. C., White, S. H., (1996) Nat. Struct. Biol, 3, pp. 842-848
Struck, D. K., Hoekstra, D., Pagano, R. E., (1981) Biochemistry, 20, pp. 4093-4099
De Kroon, A. I. P. M., Soekarjo, M. W., De Gier, J., De Kruijff, B., (1990) Biochemistry, 29, pp. 8229-8240
Eftink, M. R., Ghiron, C. A., (1976) J. Phys. Chem, 80, pp. 486-493
Killian, J. A., Trouard, T. P., Greathouse, D. V., Chupin, V., Lindblom, G., (1994) FEBS Lett, 348, pp. 161-165
Hwang, T. L., Shaka, A. J., (1995) J. Magn. Reson. A, 112, pp. 275-279
Yau, W. M., Wimley, W. C., Gawrisch, K., White, S. H., (1998) Biochemistry, 37, pp. 14713-14718
Thiaudi re, E., Siffert, O., Talbot, J. C., Bolard, J., Alouf, J. E., Dufourcq, J., (1991) Eur. J. Biochem, 195, pp. 203-213
Wishart, D. S., Sykes, B. D., Richards, F. M., (1992) Biochemistry, 31, pp. 1647-1651
Richardson, C. D., Scheid, A., Choppin, P. W., (1980) Virology, 105, pp. 205-222
Silburn, K. A., McPhee, D. A., Maerz, A. L., Poumbourios, P., Whittaker, R. G., Kirkpatrick, A., Reilly, W. G., Curtain, C. C., (1998) AIDS Res. Hum. Retrovirus, 14, pp. 385-392
Delahunty, M. D., Rhee, I., Freed, E. O., Bonifacino, J. S., (1996) Virology, 218, pp. 94-102
Freitas, M. S., Gaspar, L. P., Lorenzoni, M., Almeida, F. C. L., Tinoco, L. W., Almeida, M. S., Maia, L. F., Silva, J. L., (2007) J. Biol. Chem, 282, pp. 27306-27314
Lai, A. L., Tamm, L. K., (2007) J. Biol. Chem, 282, pp. 23946-23956
Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein
Glycoprotein H (gH) of herpes simplex virus type I (HSV-1) is involved in the complex mechanism of membrane fusion of the viral envelope with the host cell. Membrane interacting regions and potential fusion peptides have been identified in HSV-1 gH as well as glycoprotein B (gB). Because of the complex fusion mechanism of HSV-1, which requires four viral glycoproteins, and because there are only structural data for gB and glycoprotein D, many questions regarding the mechanism by which HSV-1 fuses its envelope with the host cell membrane remain unresolved. Previous studies have shown that peptides derived from certain regions of gH have the potential to interact with membranes, and based on these findings we have generated a set of peptides containing mutations in one of these domains, gH-(626-644), to investigate further the functional role of this region. Using a combination of biochemical, spectroscopic, and nuclear magnetic resonance techniques, we showed that the alpha-helical nature of this stretch of amino acids in gH is important for membrane interaction and that the aromatic residues, tryptophan and tyrosine, are critical for induction of fusion.
Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein
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