Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (555 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Export to BibTeX Export to EndNote
Paper type: Journal Article, In Vitro, Research Support, Non-U. S. Gov'T,
Impact factor: 4.672, 5-year impact factor: 4.68
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952626078&partnerID=40&md5=17d82c20b7ae6b9f4e4e124ee47f2107
Keywords: Antiinfective Agent, Beta Defensin 1, Human Beta Defensin 1 Derivative, Human Beta Defensin 3 Derivative, Sodium Chloride, Unclassified Drug, Animal Cell, Antibacterial Activity, Antimicrobial Activity, Antiviral Activity, Article, Chemotaxis, Controlled Study, Drug Design, Drug Synthesis, Granulocyte, Herpes Simplex Virus, Monocyte, Nonhuman, Priority Journal, Structure Activity Relation, Amino Acid Sequence, Anti-Bacterial Agents, Anti-Infective Agents, Antiviral Agents, Beta-Defensins, Leukocyte, Enterobacteriaceae, Herpesvirus 1, Microbial Sensitivity Tests, Models, Molecular, Molecular Sequence Data, Protein Engineering, Protein Structure, Tertiary, Recombinant Proteins, Sequence Homology,
Affiliations:
*** IBB - CNR ***
CEINGE-Biotecnologie Avanzate, Naples, Italy. salvator@unina.it
Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy
Dipartimento di Scienze Biologiche, Sezione di Biostrutture, Università di Napoli Federico II, Naples, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
Centro Interuniversitario di Ricerca Sui Peptidi Bioattivi, Naples, Italy
Dipartimento di Medicina Sperimentale, Seconda Università di Napoli, Naples, Italy
Facoltà di Scienze, Università del Molise, Isernia, Italy
Center for Human Genetics, University of Leuven, Leuven, Belgium
Scuola Europea di Medicina Molecolare (SEMM), Naples, Italy
IRCCS-Fondazione SDN, Naples, Italy
Clinica Pineta Grande, Castelvolturno, Caserta, Italy
Facolt di Scienze, Universit del Molise, Isernia, Italy
References:
Bai, Y., Liu, S., Jiang, P., Zhou, L., Li, J., Tang, C., Verma, C., Pervushin, K., Structure-dependent charge density as a determinant of antimicrobial activity of peptide analogues of defensin (2009) Biochemistry, 48, pp. 7229-723
Bauer, F., Schweimer, K., Kluver, E., Conejo-Garcia, J.-R., Forssmann, W.-G., Rosch, P., Adermann, K., Sticht, H., Structure determination of human and murine β-defensins reveals structural conservation in the absence of significant sequence similarity (2001) Protein Science, 10 (12), pp. 2470-2479. , DOI 10.1110/ps.ps.24401
Cole, A.M., Lehrer, R.I., Minidefensins: Antimicrobial peptides with activity against HIV-1 (2003) Curr. Pharm. Des., 9, pp. 1463-1473
Cole, A.M., Ganz, T., Human antimicrobial peptides: Analysis and application (2000) Biotechniques, 29, pp. 822-831
Conejo-Garcia, J.R., Jaumann, F., Schulz, S., Krause, A., Rodriguez- Jiménez, J., Forsmann, U., Andermann, K., Bals, R., Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity (2001) Cell Tissue Res., 306, pp. 257-264
Daher, K.A., Selsted, M.E., Lehrer, R.I., Direct inactivation of viruses by human granulocyte defensins (1986) Journal of Virology, 60 (3), pp. 1068-1074
Forrester, A., Farrell, H., Wilkinson, G., Kaye, J., Davis-Poynter, N., Minson, T., Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted (1992) J. Virol., 66, pp. 341-348
Ganz, T., Defensins: Antimicrobial peptides of innate immunity (2003) Nat. Rev. Immunol., 3, pp. 710-720
Goldman, M.J., Anderson, G.M., Stolzenberg, E.D., Kari, U.P., Zasloff, M., Wilson, J.M., Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis (1997) Cell, 88, pp. 553-560
Harder, J., Bartels, J., Christophers, E., Schroder, J.M., Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic (2001) J. Biol. Chem., 276, pp. 5707-5713
Hoover, D.M., Chertov, O., Lubkowski, J., The structure of human beta-defensin-1: New insights into structural properties of beta-defensins (2001) J. Biol. Chem., 276, pp. 39021-39026
Hoover, D.M., Rajashankar, K.R., Blumenthal, R., Puri, A., Oppenheim, J.J., Chertov, O., Lubkovski, J., The structure of human beta-defensin-2 shows evidence of higher order oligomerization (2000) J. Biol. Chem., 275, pp. 32911-32918
Hoover, D.M., Wu, Z., Tucker, K., Lu, W., Lubkowski, J., Antimicrobial characterization of human beta-defensin 3 derivatives (2003) Antimicrob. Agents Chemother., 47, pp. 2804-2809
Krishnakumari, V., Rangaraj, N., Nagaraj, R., Antifungal activity of human beta defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1-3 (2009) Antimicrob. Agents Chemother., 53, pp. 256-260
Lehrer, R.I., Primate defensins (2004) Nat. Rev. Microbiol., 2, pp. 727-738
Maisetta, G., Batoni, G., Esin, S., Florio, W., Bottai, D., Favilli, F., Campa, M., In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains (2006) Antimicrob. Agents Chemother., 50, pp. 806-809
Niyonsaba, F., Ogawa, H., Nagaoka, I., Human β-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils (2004) Immunology, 111 (3), pp. 273-281. , DOI 10.1111/j.0019-2805.2004.01816.x
Pazgier, M., Hoover, D.M., Yang, D., Lu, W., Lubkowski, J., Human beta-defensins (2006) Cell. Mol. Life Sci., 63, pp. 1294-1313
Quinones-Mateau, M.E., Lederman, M.M., Feng, Z., Chakraborty, B., Weber, J., Rangel, H.R., Marotta, M.L., Weinberg, A., Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication (2003) AIDS, 17, pp. 39-48
Ratjen, F., Doring, G., Cystic fibrosis (2003) Lancet, 361, pp. 681-689
Rohrl, J., Yang, D., Oppenheim, J.J., Hehlgans, T., Identification and biological characterization of mouse beta-defensin 14, the orthologue of human beta-defensin 3 (2008) J. Biol. Chem., 283, pp. 5414-5419
Sahl, H.G., Pag, U., Bonness, S., Wagner, S., Antcheva, N., Tossi, A., Mammalian defensins: Structures and mechanism of antibiotic activity (2005) J. Leukoc. Biol., 77, pp. 466-475
Sahly, H., Schubert, S., Harder, J., Rautenberg, P., Ullmann, U., Schroder, J., Podschun, R., Burkholderia is highly resistant to human beta-defensin 3 (2003) Antimicrob. Agents Chemother., 47, pp. 1739-1741
Sawai, M.V., Jia, H.P., Liu, L., Aseyev, V., Wiencek, J.M., McCray Jr., P.B., Ganz, T., Tack, B.F., The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment (2001) Biochemistry, 40, pp. 3810-3816
Schibli, D.J., Hunter, H.N., Aseyev, V., Starner, T.D., Wiencek, J.M., McCray Jr., P.B., Tack, B.F., Vogel, H.J., The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus (2002) J. Biol. Chem., 277, pp. 8279-8289
Selsted, M.E., Ouellette, A.J., Mammalian defensins in the antimicrobial immune response (2005) Nat. Immunol., 6, pp. 551-557
Sinha, S., Cheshenko, N., Lehrer, R.I., Herold, B.C., NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2 (2003) Antimicrob. Agents Chemother., 47, pp. 494-500
Smith, J.J., Travis, S.M., Greenberg, E.P., Welsh, M.J., Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid (1996) Cell, 85 (2), pp. 229-236. , DOI 10.1016/S0092-8674(00)81099-5
Starner, T.D., Agerberth, B., Gudmundsson, G.H., McCray Jr., P.B., Expression and activity of beta-defensins and LL-37 in the developing human lung (2005) J. Immunol., 174, pp. 1608-1615
(2006) StemSep Cell Technical Manual, , Stem Cell Technologies Stem Cell Technologies, Vancouver, British Columbia, Canada
Sun, L., Finnegan, C.M., Kish-Catalone, T., Blumenthal, R., Garzino-Demo, P., La Terra Maggiore, G.M., Berrone, S., Garzino-Demo, A., Human β-defensins suppress human immunodeficiency virus infection: Potential role in mucosal protection (2005) J. Virol., 79, pp. 14318-14329
Taylor, K., Clarke, D.J., McCullough, B., Chin, W., Seo, E., Yang, D., Oppenheim, J., Dorin, J.R., Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3 (2008) J. Biol. Chem., 283, pp. 6631-6639
Tomita, T., Hitomi, S., Nagase, T., Matsui, H., Matsuse, T., Kimura, S., Ouchi, Y., Effect of ions on antibacterial activity of human beta defensin 2 (2000) Microbiol. Immunol., 44, pp. 749-754
Weinberg, A., Quinones-Mateu, M.E., Lederman, M.M., Role of human beta-defensins in HIV infection (2006) Adv. Dent. Res., 19, pp. 42-48
Wu, Z., Hoover, D.M., Yang, D., Boulegue, C., Santamaria, F., Oppenheim, J.J., Lubkowski, J., Lu, W., Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3 (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 8880-8885
Yadava, P., Zhang, C., Sun, J., Hughes, J.A., Antimicrobial activities of human beta-defensins against Bacillus species (2006) Int. J. Antimicrob. Agents, 28, pp. 132-137
Yasin, B., Wang, W., Pang, M., Cheshenko, N., Hong, T., Waring, A.J., Herold, B.C., Lehrer, R.I., Theta Defensins Protect Cells from Infection by Herpes Simplex Virus by Inhibiting Viral Adhesion and Entry (2004) Journal of Virology, 78 (10), pp. 5147-5156. , DOI 10.1128/JVI.78.10.5147-5156.2004
Cole, A. M., Lehrer, R. I., Minidefensins: Antimicrobial peptides with activity against HIV-1 (2003) Curr. Pharm. Des., 9, pp. 1463-1473
Cole, A. M., Ganz, T., Human antimicrobial peptides: Analysis and application (2000) Biotechniques, 29, pp. 822-831
Conejo-Garcia, J. R., Jaumann, F., Schulz, S., Krause, A., Rodriguez- Jim nez, J., Forsmann, U., Andermann, K., Bals, R., Identification of a novel, multifunctional -defensin (human -defensin 3) with specific antimicrobial activity (2001) Cell Tissue Res., 306, pp. 257-264
Daher, K. A., Selsted, M. E., Lehrer, R. I., Direct inactivation of viruses by human granulocyte defensins (1986) Journal of Virology, 60 (3), pp. 1068-1074
Goldman, M. J., Anderson, G. M., Stolzenberg, E. D., Kari, U. P., Zasloff, M., Wilson, J. M., Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis (1997) Cell, 88, pp. 553-560
Hoover, D. M., Chertov, O., Lubkowski, J., The structure of human beta-defensin-1: New insights into structural properties of beta-defensins (2001) J. Biol. Chem., 276, pp. 39021-39026
Hoover, D. M., Rajashankar, K. R., Blumenthal, R., Puri, A., Oppenheim, J. J., Chertov, O., Lubkovski, J., The structure of human beta-defensin-2 shows evidence of higher order oligomerization (2000) J. Biol. Chem., 275, pp. 32911-32918
Hoover, D. M., Wu, Z., Tucker, K., Lu, W., Lubkowski, J., Antimicrobial characterization of human beta-defensin 3 derivatives (2003) Antimicrob. Agents Chemother., 47, pp. 2804-2809
Lehrer, R. I., Primate defensins (2004) Nat. Rev. Microbiol., 2, pp. 727-738
Sahl, H. G., Pag, U., Bonness, S., Wagner, S., Antcheva, N., Tossi, A., Mammalian defensins: Structures and mechanism of antibiotic activity (2005) J. Leukoc. Biol., 77, pp. 466-475
Sawai, M. V., Jia, H. P., Liu, L., Aseyev, V., Wiencek, J. M., McCray Jr., P. B., Ganz, T., Tack, B. F., The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment (2001) Biochemistry, 40, pp. 3810-3816
Schibli, D. J., Hunter, H. N., Aseyev, V., Starner, T. D., Wiencek, J. M., McCray Jr., P. B., Tack, B. F., Vogel, H. J., The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus (2002) J. Biol. Chem., 277, pp. 8279-8289
Selsted, M. E., Ouellette, A. J., Mammalian defensins in the antimicrobial immune response (2005) Nat. Immunol., 6, pp. 551-557
Smith, J. J., Travis, S. M., Greenberg, E. P., Welsh, M. J., Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid (1996) Cell, 85 (2), pp. 229-236. , DOI 10. 1016/S0092-8674 (00) 81099-5
Starner, T. D., Agerberth, B., Gudmundsson, G. H., McCray Jr., P. B., Expression and activity of beta-defensins and LL-37 in the developing human lung (2005) J. Immunol., 174, pp. 1608-1615
(2006) StemSep Cell Technical Manual, , Stem Cell Technologies Stem Cell Technologies, Vancouver, British Columbia, Canada
Wu, Z., Hoover, D. M., Yang, D., Boulegue, C., Santamaria, F., Oppenheim, J. J., Lubkowski, J., Lu, W., Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human -defensin 3 (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 8880-8885
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Export to BibTeX Export to EndNote
Paper type: Journal Article, In Vitro, Research Support, Non-U. S. Gov'T,
Impact factor: 4.672, 5-year impact factor: 4.68
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952626078&partnerID=40&md5=17d82c20b7ae6b9f4e4e124ee47f2107
Keywords: Antiinfective Agent, Beta Defensin 1, Human Beta Defensin 1 Derivative, Human Beta Defensin 3 Derivative, Sodium Chloride, Unclassified Drug, Animal Cell, Antibacterial Activity, Antimicrobial Activity, Antiviral Activity, Article, Chemotaxis, Controlled Study, Drug Design, Drug Synthesis, Granulocyte, Herpes Simplex Virus, Monocyte, Nonhuman, Priority Journal, Structure Activity Relation, Amino Acid Sequence, Anti-Bacterial Agents, Anti-Infective Agents, Antiviral Agents, Beta-Defensins, Leukocyte, Enterobacteriaceae, Herpesvirus 1, Microbial Sensitivity Tests, Models, Molecular, Molecular Sequence Data, Protein Engineering, Protein Structure, Tertiary, Recombinant Proteins, Sequence Homology,
Affiliations:
*** IBB - CNR ***
CEINGE-Biotecnologie Avanzate, Naples, Italy. salvator@unina.it
Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy
Dipartimento di Scienze Biologiche, Sezione di Biostrutture, Università di Napoli Federico II, Naples, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
Centro Interuniversitario di Ricerca Sui Peptidi Bioattivi, Naples, Italy
Dipartimento di Medicina Sperimentale, Seconda Università di Napoli, Naples, Italy
Facoltà di Scienze, Università del Molise, Isernia, Italy
Center for Human Genetics, University of Leuven, Leuven, Belgium
Scuola Europea di Medicina Molecolare (SEMM), Naples, Italy
IRCCS-Fondazione SDN, Naples, Italy
Clinica Pineta Grande, Castelvolturno, Caserta, Italy
Facolt di Scienze, Universit del Molise, Isernia, Italy
References:
Bai, Y., Liu, S., Jiang, P., Zhou, L., Li, J., Tang, C., Verma, C., Pervushin, K., Structure-dependent charge density as a determinant of antimicrobial activity of peptide analogues of defensin (2009) Biochemistry, 48, pp. 7229-723
Bauer, F., Schweimer, K., Kluver, E., Conejo-Garcia, J.-R., Forssmann, W.-G., Rosch, P., Adermann, K., Sticht, H., Structure determination of human and murine β-defensins reveals structural conservation in the absence of significant sequence similarity (2001) Protein Science, 10 (12), pp. 2470-2479. , DOI 10.1110/ps.ps.24401
Cole, A.M., Lehrer, R.I., Minidefensins: Antimicrobial peptides with activity against HIV-1 (2003) Curr. Pharm. Des., 9, pp. 1463-1473
Cole, A.M., Ganz, T., Human antimicrobial peptides: Analysis and application (2000) Biotechniques, 29, pp. 822-831
Conejo-Garcia, J.R., Jaumann, F., Schulz, S., Krause, A., Rodriguez- Jiménez, J., Forsmann, U., Andermann, K., Bals, R., Identification of a novel, multifunctional β-defensin (human β-defensin 3) with specific antimicrobial activity (2001) Cell Tissue Res., 306, pp. 257-264
Daher, K.A., Selsted, M.E., Lehrer, R.I., Direct inactivation of viruses by human granulocyte defensins (1986) Journal of Virology, 60 (3), pp. 1068-1074
Forrester, A., Farrell, H., Wilkinson, G., Kaye, J., Davis-Poynter, N., Minson, T., Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted (1992) J. Virol., 66, pp. 341-348
Ganz, T., Defensins: Antimicrobial peptides of innate immunity (2003) Nat. Rev. Immunol., 3, pp. 710-720
Goldman, M.J., Anderson, G.M., Stolzenberg, E.D., Kari, U.P., Zasloff, M., Wilson, J.M., Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis (1997) Cell, 88, pp. 553-560
Harder, J., Bartels, J., Christophers, E., Schroder, J.M., Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic (2001) J. Biol. Chem., 276, pp. 5707-5713
Hoover, D.M., Chertov, O., Lubkowski, J., The structure of human beta-defensin-1: New insights into structural properties of beta-defensins (2001) J. Biol. Chem., 276, pp. 39021-39026
Hoover, D.M., Rajashankar, K.R., Blumenthal, R., Puri, A., Oppenheim, J.J., Chertov, O., Lubkovski, J., The structure of human beta-defensin-2 shows evidence of higher order oligomerization (2000) J. Biol. Chem., 275, pp. 32911-32918
Hoover, D.M., Wu, Z., Tucker, K., Lu, W., Lubkowski, J., Antimicrobial characterization of human beta-defensin 3 derivatives (2003) Antimicrob. Agents Chemother., 47, pp. 2804-2809
Krishnakumari, V., Rangaraj, N., Nagaraj, R., Antifungal activity of human beta defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1-3 (2009) Antimicrob. Agents Chemother., 53, pp. 256-260
Lehrer, R.I., Primate defensins (2004) Nat. Rev. Microbiol., 2, pp. 727-738
Maisetta, G., Batoni, G., Esin, S., Florio, W., Bottai, D., Favilli, F., Campa, M., In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains (2006) Antimicrob. Agents Chemother., 50, pp. 806-809
Niyonsaba, F., Ogawa, H., Nagaoka, I., Human β-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils (2004) Immunology, 111 (3), pp. 273-281. , DOI 10.1111/j.0019-2805.2004.01816.x
Pazgier, M., Hoover, D.M., Yang, D., Lu, W., Lubkowski, J., Human beta-defensins (2006) Cell. Mol. Life Sci., 63, pp. 1294-1313
Quinones-Mateau, M.E., Lederman, M.M., Feng, Z., Chakraborty, B., Weber, J., Rangel, H.R., Marotta, M.L., Weinberg, A., Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication (2003) AIDS, 17, pp. 39-48
Ratjen, F., Doring, G., Cystic fibrosis (2003) Lancet, 361, pp. 681-689
Rohrl, J., Yang, D., Oppenheim, J.J., Hehlgans, T., Identification and biological characterization of mouse beta-defensin 14, the orthologue of human beta-defensin 3 (2008) J. Biol. Chem., 283, pp. 5414-5419
Sahl, H.G., Pag, U., Bonness, S., Wagner, S., Antcheva, N., Tossi, A., Mammalian defensins: Structures and mechanism of antibiotic activity (2005) J. Leukoc. Biol., 77, pp. 466-475
Sahly, H., Schubert, S., Harder, J., Rautenberg, P., Ullmann, U., Schroder, J., Podschun, R., Burkholderia is highly resistant to human beta-defensin 3 (2003) Antimicrob. Agents Chemother., 47, pp. 1739-1741
Sawai, M.V., Jia, H.P., Liu, L., Aseyev, V., Wiencek, J.M., McCray Jr., P.B., Ganz, T., Tack, B.F., The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment (2001) Biochemistry, 40, pp. 3810-3816
Schibli, D.J., Hunter, H.N., Aseyev, V., Starner, T.D., Wiencek, J.M., McCray Jr., P.B., Tack, B.F., Vogel, H.J., The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus (2002) J. Biol. Chem., 277, pp. 8279-8289
Selsted, M.E., Ouellette, A.J., Mammalian defensins in the antimicrobial immune response (2005) Nat. Immunol., 6, pp. 551-557
Sinha, S., Cheshenko, N., Lehrer, R.I., Herold, B.C., NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2 (2003) Antimicrob. Agents Chemother., 47, pp. 494-500
Smith, J.J., Travis, S.M., Greenberg, E.P., Welsh, M.J., Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid (1996) Cell, 85 (2), pp. 229-236. , DOI 10.1016/S0092-8674(00)81099-5
Starner, T.D., Agerberth, B., Gudmundsson, G.H., McCray Jr., P.B., Expression and activity of beta-defensins and LL-37 in the developing human lung (2005) J. Immunol., 174, pp. 1608-1615
(2006) StemSep Cell Technical Manual, , Stem Cell Technologies Stem Cell Technologies, Vancouver, British Columbia, Canada
Sun, L., Finnegan, C.M., Kish-Catalone, T., Blumenthal, R., Garzino-Demo, P., La Terra Maggiore, G.M., Berrone, S., Garzino-Demo, A., Human β-defensins suppress human immunodeficiency virus infection: Potential role in mucosal protection (2005) J. Virol., 79, pp. 14318-14329
Taylor, K., Clarke, D.J., McCullough, B., Chin, W., Seo, E., Yang, D., Oppenheim, J., Dorin, J.R., Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3 (2008) J. Biol. Chem., 283, pp. 6631-6639
Tomita, T., Hitomi, S., Nagase, T., Matsui, H., Matsuse, T., Kimura, S., Ouchi, Y., Effect of ions on antibacterial activity of human beta defensin 2 (2000) Microbiol. Immunol., 44, pp. 749-754
Weinberg, A., Quinones-Mateu, M.E., Lederman, M.M., Role of human beta-defensins in HIV infection (2006) Adv. Dent. Res., 19, pp. 42-48
Wu, Z., Hoover, D.M., Yang, D., Boulegue, C., Santamaria, F., Oppenheim, J.J., Lubkowski, J., Lu, W., Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3 (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 8880-8885
Yadava, P., Zhang, C., Sun, J., Hughes, J.A., Antimicrobial activities of human beta-defensins against Bacillus species (2006) Int. J. Antimicrob. Agents, 28, pp. 132-137
Yasin, B., Wang, W., Pang, M., Cheshenko, N., Hong, T., Waring, A.J., Herold, B.C., Lehrer, R.I., Theta Defensins Protect Cells from Infection by Herpes Simplex Virus by Inhibiting Viral Adhesion and Entry (2004) Journal of Virology, 78 (10), pp. 5147-5156. , DOI 10.1128/JVI.78.10.5147-5156.2004
Cole, A. M., Lehrer, R. I., Minidefensins: Antimicrobial peptides with activity against HIV-1 (2003) Curr. Pharm. Des., 9, pp. 1463-1473
Cole, A. M., Ganz, T., Human antimicrobial peptides: Analysis and application (2000) Biotechniques, 29, pp. 822-831
Conejo-Garcia, J. R., Jaumann, F., Schulz, S., Krause, A., Rodriguez- Jim nez, J., Forsmann, U., Andermann, K., Bals, R., Identification of a novel, multifunctional -defensin (human -defensin 3) with specific antimicrobial activity (2001) Cell Tissue Res., 306, pp. 257-264
Daher, K. A., Selsted, M. E., Lehrer, R. I., Direct inactivation of viruses by human granulocyte defensins (1986) Journal of Virology, 60 (3), pp. 1068-1074
Goldman, M. J., Anderson, G. M., Stolzenberg, E. D., Kari, U. P., Zasloff, M., Wilson, J. M., Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis (1997) Cell, 88, pp. 553-560
Hoover, D. M., Chertov, O., Lubkowski, J., The structure of human beta-defensin-1: New insights into structural properties of beta-defensins (2001) J. Biol. Chem., 276, pp. 39021-39026
Hoover, D. M., Rajashankar, K. R., Blumenthal, R., Puri, A., Oppenheim, J. J., Chertov, O., Lubkovski, J., The structure of human beta-defensin-2 shows evidence of higher order oligomerization (2000) J. Biol. Chem., 275, pp. 32911-32918
Hoover, D. M., Wu, Z., Tucker, K., Lu, W., Lubkowski, J., Antimicrobial characterization of human beta-defensin 3 derivatives (2003) Antimicrob. Agents Chemother., 47, pp. 2804-2809
Lehrer, R. I., Primate defensins (2004) Nat. Rev. Microbiol., 2, pp. 727-738
Sahl, H. G., Pag, U., Bonness, S., Wagner, S., Antcheva, N., Tossi, A., Mammalian defensins: Structures and mechanism of antibiotic activity (2005) J. Leukoc. Biol., 77, pp. 466-475
Sawai, M. V., Jia, H. P., Liu, L., Aseyev, V., Wiencek, J. M., McCray Jr., P. B., Ganz, T., Tack, B. F., The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment (2001) Biochemistry, 40, pp. 3810-3816
Schibli, D. J., Hunter, H. N., Aseyev, V., Starner, T. D., Wiencek, J. M., McCray Jr., P. B., Tack, B. F., Vogel, H. J., The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus (2002) J. Biol. Chem., 277, pp. 8279-8289
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Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity
Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high salt levels. We have designed and synthesized seven novel hBD analogs, constituted by different domains of hBD1 (which is constitutively expressed in humans) and of hBD3 (which is induced by microorganisms and inflammatory factors in humans), that would maintain and potentially increase the wild-type antimicrobial activities and be salt resistant. We have compared the antibacterial, antiviral, and chemotactic activities of the analogs with those of hBD1 and hBD3. We show that the hBD1 internal region and the hBD3 C-terminal region are critical for antibacterial activity also at high salt concentrations, whereas deletion of the N-terminal region of hBD3 results in an increase in antibacterial activity. All analogs inhibited herpes simplex virus; antiviral activity was enhanced by the hBD1 internal region and the hBD3 C-terminal region. Wild-type and analog peptides were chemotactic for granulocytes and monocytes, irrespective of the salt concentrations. These new peptides may have therapeutic potential.
Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high salt levels. We have designed and synthesized seven novel hBD analogs, constituted by different domains of hBD1 (which is constitutively expressed in humans) and of hBD3 (which is induced by microorganisms and inflammatory factors in humans), that would maintain and potentially increase the wild-type antimicrobial activities and be salt resistant. We have compared the antibacterial, antiviral, and chemotactic activities of the analogs with those of hBD1 and hBD3. We show that the hBD1 internal region and the hBD3 C-terminal region are critical for antibacterial activity also at high salt concentrations, whereas deletion of the N-terminal region of hBD3 results in an increase in antibacterial activity. All analogs inhibited herpes simplex virus; antiviral activity was enhanced by the hBD1 internal region and the hBD3 C-terminal region. Wild-type and analog peptides were chemotactic for granulocytes and monocytes, irrespective of the salt concentrations. These new peptides may have therapeutic potential.
Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity
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Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
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Graziano G, Merlino A
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Avitabile C, D'Andrea LD, Romanelli A
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Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
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Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
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D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
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Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
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Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
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Briganti F, Tedeschi E, Leone G, Marseglia M, Cicala D, Giamundo M, Napoli M, Caranci F
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Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
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Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (888 views)
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Impact Factor: 1.862
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Pica A, Russo Krauss I, Castellano I, La Cara F, Graziano G, Sica F, Merlino A
* Effect Of Nacl On The Conformational Stability Of The Thermophilic Gamma-Glutamyltranspeptidase From Geobacillus Thermodenitrificans: Implication For Globular Protein Halotolerance (334 views)
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
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Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
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Ascione G, de Pascale D, De Santi C, Pedone C, Dathan NA, Monti SM
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Capparelli R, Romanelli A, Iannaccone M, Nocerino N, Ripa R, Pensato S, Pedone C, Iannelli D
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Impact Factor: 4.351
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Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
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Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
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Impact Factor: 3.325
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Ronga L, Palladino P, Tizzano B, Marasco D, Benedetti E, Ragone R, Rossi F
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Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
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Romano M, Giojelli A, Tamburrini O, Salvatore M
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Romano M, Giojelli A, Mainenti PP, Tamburrini O, Salvatore M
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* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (408 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
View Export to BibTeX Export to EndNote
Pica A, Graziano G
* On the effect of sodium chloride and sodium sulfate on cold denaturation (307 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015; 10(7): N/D-N/D.
Impact Factor: 3.057
View Export to BibTeX Export to EndNote
Malgieri G, Avitabile C, Palmieri M, D'Andrea LD, Isernia C, Romanelli A, Fattorusso R
* Structural basis of a temporin 1b analogue antimicrobial activity against gram negative bacteria determined by CD and NMR techniques in cellular environment (541 views)
Acs Chem Biol (ISSN: 1554-8929), 2015; 10(4): 965-969.
Impact Factor: 5.09
View Export to BibTeX Export to EndNote
Calce E, Mignogna E, Bugatti V, Galdiero M, Vittoria V, De Luca S
* Pectin functionalized with natural fatty acids as antimicrobial agent (389 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2014 Jul; 68: 28-32.
Impact Factor: 2.858
View Export to BibTeX Export to EndNote
Graziano G, Merlino A
* Molecular bases of protein halotolerance (363 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Apr; 1844(4): 850-858.
Impact Factor: 4.882
View Export to BibTeX Export to EndNote
Avitabile C, D'Andrea LD, Romanelli A
* Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells (498 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2014 Mar 12; 4: 4293-4293.
Impact Factor: 5.578
View Export to BibTeX Export to EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (727 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
View Export to BibTeX Export to EndNote
Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
* Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability (526 views)
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Impact Factor: 4.882
View Export to BibTeX Export to EndNote
D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
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Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Feb; 97(1): 114-120.
Impact Factor: 2.963
View Export to BibTeX Export to EndNote
Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (398 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Sep; 69(Pt9): 1697-1706.
Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
* Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (488 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
Impact Factor: 3.829
View Export to BibTeX Export to EndNote
Briganti F, Tedeschi E, Leone G, Marseglia M, Cicala D, Giamundo M, Napoli M, Caranci F
* Endovascular treatment of vertebro-vertebral arteriovenous fistula (381 views)
Neuroradiol J (ISSN: 1971-4009, 1971-4009print), 2013 Jun; 26(3): 339-346.
Impact Factor: 2.16
View Export to BibTeX Export to EndNote
Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
* Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines (552 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2013 Apr; 57(4): 1701-1708.
Impact Factor: 4.451
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (888 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Pica A, Russo Krauss I, Castellano I, La Cara F, Graziano G, Sica F, Merlino A
* Effect Of Nacl On The Conformational Stability Of The Thermophilic Gamma-Glutamyltranspeptidase From Geobacillus Thermodenitrificans: Implication For Globular Protein Halotolerance (334 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Jan; 1834(1): 149-157.
Impact Factor: 3.191
View Export to BibTeX Export to EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
* Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds (505 views)
Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723), 2012 Nov; 31(11): 3047-3055.
Impact Factor: 3.024
View Export to BibTeX Export to EndNote
Ascione G, de Pascale D, De Santi C, Pedone C, Dathan NA, Monti SM
* Native expression and purification of hormone-sensitive lipase from Psychrobacter sp. TA144 enhances protein stability and activity (509 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2012 Apr 13; 420(3): 542-546.
Impact Factor: 2.406
View Export to BibTeX Export to EndNote
Capparelli R, Romanelli A, Iannaccone M, Nocerino N, Ripa R, Pensato S, Pedone C, Iannelli D
* Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (452 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 28; 4(9): e7191-e7191.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (307 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
View Export to BibTeX Export to EndNote
Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
* Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (315 views)
Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633.
Impact Factor: 6.594
View Export to BibTeX Export to EndNote
Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (394 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
View Export to BibTeX Export to EndNote
Ronga L, Palladino P, Tizzano B, Marasco D, Benedetti E, Ragone R, Rossi F
* Effect of salts on the structural behavior of hPrP α2-helix-derived analogues: The counterion perspective (454 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 790-795.
Impact Factor: 1.801
View Export to BibTeX Export to EndNote
Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (385 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Romano M, Giojelli A, Tamburrini O, Salvatore M
* Chemoembolization for hepatocellular carcinoma: Effect of intraarterial lidocaine in peri- and post-procedural pain and hospitalization (424 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2003 Apr; 105(4): 350-355.
Impact Factor: 1.368
View Export to BibTeX Export to EndNote
Romano M, Giojelli A, Mainenti PP, Tamburrini O, Salvatore M
* Upper thoracic sympathetic chain neurolysis under CT guidance. A two year follow-up in patients with palmar and axillary hyperhidrosis (385 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2002 Nov; 104(5-6): 421-425.
Impact Factor: 1.368
View Export to BibTeX Export to EndNote
27 Records (26 excluding Abstracts).
Total impact factor: 95.004 (90.653 excluding Abstracts).
Total 5 year impact factor: 100.106 (95.723 excluding Abstracts).
Total impact factor: 95.004 (90.653 excluding Abstracts).
Total 5 year impact factor: 100.106 (95.723 excluding Abstracts).
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