Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (671 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
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Paper type: Journal Article, In Vitro, Research Support, Non-U. S. Gov'T,
Impact factor: 4.672, 5-year impact factor: 4.68
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952626078&partnerID=40&md5=17d82c20b7ae6b9f4e4e124ee47f2107
Keywords: Antiinfective Agent, Beta Defensin 1, Human Beta Defensin 1 Derivative, Human Beta Defensin 3 Derivative, Sodium Chloride, Unclassified Drug, Animal Cell, Antibacterial Activity, Antimicrobial Activity, Antiviral Activity, Article, Chemotaxis, Controlled Study, Drug Design, Drug Synthesis, Granulocyte, Herpes Simplex Virus, Monocyte, Nonhuman, Priority Journal, Structure Activity Relation, Amino Acid Sequence, Anti-Bacterial Agents, Anti-Infective Agents, Antiviral Agents, Beta-Defensins, Leukocyte, Enterobacteriaceae, Herpesvirus 1, Microbial Sensitivity Tests, Models, Molecular, Molecular Sequence Data, Protein Engineering, Protein Structure, Tertiary, Recombinant Proteins, Sequence Homology,
Affiliations:
*** IBB - CNR ***
CEINGE-Biotecnologie Avanzate, Naples, Italy. salvator@unina.it
Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy
Dipartimento di Scienze Biologiche, Sezione di Biostrutture, Università di Napoli Federico II, Naples, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
Centro Interuniversitario di Ricerca Sui Peptidi Bioattivi, Naples, Italy
Dipartimento di Medicina Sperimentale, Seconda Università di Napoli, Naples, Italy
Facoltà di Scienze, Università del Molise, Isernia, Italy
Center for Human Genetics, University of Leuven, Leuven, Belgium
Scuola Europea di Medicina Molecolare (SEMM), Naples, Italy
IRCCS-Fondazione SDN, Naples, Italy
Clinica Pineta Grande, Castelvolturno, Caserta, Italy
Facolt di Scienze, Universit del Molise, Isernia, Italy
References:
Not available.
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Export to BibTeX Export to EndNote
Paper type: Journal Article, In Vitro, Research Support, Non-U. S. Gov'T,
Impact factor: 4.672, 5-year impact factor: 4.68
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77952626078&partnerID=40&md5=17d82c20b7ae6b9f4e4e124ee47f2107
Keywords: Antiinfective Agent, Beta Defensin 1, Human Beta Defensin 1 Derivative, Human Beta Defensin 3 Derivative, Sodium Chloride, Unclassified Drug, Animal Cell, Antibacterial Activity, Antimicrobial Activity, Antiviral Activity, Article, Chemotaxis, Controlled Study, Drug Design, Drug Synthesis, Granulocyte, Herpes Simplex Virus, Monocyte, Nonhuman, Priority Journal, Structure Activity Relation, Amino Acid Sequence, Anti-Bacterial Agents, Anti-Infective Agents, Antiviral Agents, Beta-Defensins, Leukocyte, Enterobacteriaceae, Herpesvirus 1, Microbial Sensitivity Tests, Models, Molecular, Molecular Sequence Data, Protein Engineering, Protein Structure, Tertiary, Recombinant Proteins, Sequence Homology,
Affiliations:
*** IBB - CNR ***
CEINGE-Biotecnologie Avanzate, Naples, Italy. salvator@unina.it
Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy
Dipartimento di Scienze Biologiche, Sezione di Biostrutture, Università di Napoli Federico II, Naples, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
Centro Interuniversitario di Ricerca Sui Peptidi Bioattivi, Naples, Italy
Dipartimento di Medicina Sperimentale, Seconda Università di Napoli, Naples, Italy
Facoltà di Scienze, Università del Molise, Isernia, Italy
Center for Human Genetics, University of Leuven, Leuven, Belgium
Scuola Europea di Medicina Molecolare (SEMM), Naples, Italy
IRCCS-Fondazione SDN, Naples, Italy
Clinica Pineta Grande, Castelvolturno, Caserta, Italy
Facolt di Scienze, Universit del Molise, Isernia, Italy
References:
Not available.
Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity
Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high salt levels. We have designed and synthesized seven novel hBD analogs, constituted by different domains of hBD1 (which is constitutively expressed in humans) and of hBD3 (which is induced by microorganisms and inflammatory factors in humans), that would maintain and potentially increase the wild-type antimicrobial activities and be salt resistant. We have compared the antibacterial, antiviral, and chemotactic activities of the analogs with those of hBD1 and hBD3. We show that the hBD1 internal region and the hBD3 C-terminal region are critical for antibacterial activity also at high salt concentrations, whereas deletion of the N-terminal region of hBD3 results in an increase in antibacterial activity. All analogs inhibited herpes simplex virus; antiviral activity was enhanced by the hBD1 internal region and the hBD3 C-terminal region. Wild-type and analog peptides were chemotactic for granulocytes and monocytes, irrespective of the salt concentrations. These new peptides may have therapeutic potential.
Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high salt levels. We have designed and synthesized seven novel hBD analogs, constituted by different domains of hBD1 (which is constitutively expressed in humans) and of hBD3 (which is induced by microorganisms and inflammatory factors in humans), that would maintain and potentially increase the wild-type antimicrobial activities and be salt resistant. We have compared the antibacterial, antiviral, and chemotactic activities of the analogs with those of hBD1 and hBD3. We show that the hBD1 internal region and the hBD3 C-terminal region are critical for antibacterial activity also at high salt concentrations, whereas deletion of the N-terminal region of hBD3 results in an increase in antibacterial activity. All analogs inhibited herpes simplex virus; antiviral activity was enhanced by the hBD1 internal region and the hBD3 C-terminal region. Wild-type and analog peptides were chemotactic for granulocytes and monocytes, irrespective of the salt concentrations. These new peptides may have therapeutic potential.
Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity
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Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (388 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
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Romano M, Giojelli A, Tamburrini O, Salvatore M
* Chemoembolization for hepatocellular carcinoma: Effect of intraarterial lidocaine in peri- and post-procedural pain and hospitalization (493 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2003 Apr; 105(4): 350-355.
Impact Factor: 1.368
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Romano M, Giojelli A, Mainenti PP, Tamburrini O, Salvatore M
* Upper thoracic sympathetic chain neurolysis under CT guidance. A two year follow-up in patients with palmar and axillary hyperhidrosis (407 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2002 Nov; 104(5-6): 421-425.
Impact Factor: 1.368
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27 Records (26 excluding Abstracts).
Total impact factor: 95.004 (90.653 excluding Abstracts).
Total 5 year impact factor: 100.106 (95.723 excluding Abstracts).
Total impact factor: 95.004 (90.653 excluding Abstracts).
Total 5 year impact factor: 100.106 (95.723 excluding Abstracts).
671 views. Last view on Monday 28 August 2023, 15:49:24
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