Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach(393 views) Greco A, Di Benedetto A, Howard CM, Kelly S, Nande R, Dementieva Y, Miranda M, Brunetti A, Salvatore M, Claudio L, Sarkar D, Dent P, Curiel DT, Fisher PB, Claudio PP
Mol Ther (ISSN: 1525-0024e, 1525-0016linking), 2010 Feb 18; 18(2): 295-306.
Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia 25755, USA.,
References: Damber, J.E., Aus, G., Prostate cancer (2008) Lancet, 371, pp. 1710-172
Moon, C., Park, J.C., Chae, Y.K., Yun, J.H., Kim, S., Current status of experimental therapeutics for prostate cancer (2008) Cancer Lett, 266, pp. 116-134
Shi, X.B., Gumerlock, P.H., Devere White, R.W., Molecular biology of prostate cancer (1996) World J Urol, 14, pp. 318-328
Lebedeva, I.V., Sarkar, D., Su, Z.Z., Kitada, S., Dent, P., Stein, C.A., Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24 (2003) Oncogene, 22, pp. 8758-8773
Lebedeva, I.V., Su, Z.Z., Sarkar, D., Kitada, S., Dent, P., Waxman, S., Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species (2003) Cancer Res, 63, pp. 8138-8144
Fisher, P.B., Is mda-7/IL-24 a "magic bullet" (2005) For Cancer? Cancer Res, 65, pp. 10128-10138
Fisher, P.B., Gopalkrishnan, R.V., Chada, S., Ramesh, R., Grimm, E.A., Rosenfeld, M.R., Mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: From the laboratory into the clinic (2003) Cancer Biol Ther, 2 (4 SUPPL. 1), pp. S23-S37
Lebedeva, I.V., Emdad, L., Su, Z.Z., Gupta, P., Sauane, M., Sarkar, D., Mda-7/IL-24, novel anticancer cytokine: Focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase i clinical experience (review (2007) Int J Oncol, 31, pp. 985-1007
Lebedeva, I.V., Sauane, M., Gopalkrishnan, R.V., Sarkar, D., Su, Z.Z., Gupta, P., Mda-7/IL-24: Exploiting cancer's Achilles' heel (2005) Mol Ther, 11, pp. 4-18
Sarkar, D., Dent, P., Curiel, D.T., Fisher, P.B., Acquired and innate resistance to the cancer-specifc apoptosis-inducing cytokine, mda-7/IL-24: Not insurmountable therapeutic problems (2008) Cancer Biol Ther, 7, pp. 109-112
Sarkar, D., Lebedeva, I.V., Su, Z.Z., Park, E.S., Chatman, L., Vozhilla, N., Eradication of therapy-resistant human prostate tumors using a cancer terminator virus (2007) Cancer Res, 67, pp. 5434-5442
Howard, C.M., Forsberg, F., Minimo, C., Liu, J.B., Merton, D.A., Claudio, P.P., Ultrasound guided site specifc gene delivery system using adenoviral vectors and commercial ultrasound contrast agents (2006) J Cell Physiol, 209, pp. 413-421
Jiang, H., Wang, Z., Serra, D., Frank, M.M., Amalftano, A., Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies (2004) Mol Ther, 10, pp. 1140-1142
Lawrie, A., Brisken, A.F., Francis, S.E., Cumberland, D.C., Crossman, D.C., Newman, C.M., Microbubble-enhanced ultrasound for vascular gene delivery (2000) Gene Ther, 7, pp. 2023-2027
Ng, K.Y., Liu, Y., Therapeutic ultrasound: Its application in drug delivery (2002) Med Res Rev, 22, pp. 204-223
Larina, I.V., Evers, B.M., Esenaliev, R.O., Optimal drug and gene delivery in cancer cells by ultrasound-induced cavitation (2005) Anticancer Res, 25 (1 A), pp. 149-156
Howard, C.M., The role of ultrasound contrast agents in gene therapy (2004) Appl Radiol, 33 (SUPPL), pp. 126-135
Goldberg, B.B., Liu, J.B., Forsberg, F., Ultrasound contrast agents: A review (1994) Ultrasound Med Biol, 20, pp. 319-333
Pitt, W.G., Husseini, G.A., Staples, B.J., Ultrasonic drug delivery\\\\\\\\\\\\\\\\-a general review (2004) Expert Opin Drug Deliv, 1, pp. 37-56
Dayton, P.A., Rychak, J.J., Molecular ultrasound imaging using microbubble contrast agents (2007) Front Biosci, 12, pp. 5124-5142
Cunningham, C.C., Chada, S., Merritt, J.A., Tong, A., Senzer, N., Zhang, Y., Clinical and local biological effects of an intratumoral injection of mda-7 (IL24
INGN 241) in patients with advanced carcinoma: A phase i study (2005) Mol Ther, 11, pp. 149-159
Eager, R., Harle, L., Nemunaitis, J., Ad-MDA-7
INGN 241: A review of preclinical and clinical experience (2008) Expert Opin Biol Ther, 8, pp. 1633-1643
Fisher, P.B., Sarkar, D., Lebedeva, I.V., Emdad, L., Gupta, P., Sauane, M., Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): Novel gene therapeutic for metastatic melanoma (2007) Toxicol Appl Pharmacol, 224, pp. 300-307
Inoue, S., Hartman, A., Branch, C.D., Bucana, C.D., Bekele, B.N., Stephens, L.C., Mda-7 in combination with bevacizumab treatment produces a synergistic and complete inhibitory effect on lung tumor xenograft (2007) Mol Ther, 15, pp. 287-294
Ramesh, R., Ito, I., Saito, Y., Wu, Z., Mhashikar, A.M., Wilson, D.R., Local and systemic inhibition of lung tumor growth after nanoparticle-mediated mda-7/IL-24 gene delivery (2004) DNA Cell Biol, 23, pp. 850-857
Su, Z.Z., Madireddi, M.T., Lin, J.J., Young, C.S., Kitada, S., Reed, J.C., The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice (1998) Proc Natl Acad Sci USA, 95, pp. 14400-14405
Tahara, I., Miyake, K., Hanawa, H., Kurai, T., Hirai, Y., Ishizaki, M., Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24 (2007) Mol Ther, 15, pp. 1805-1811
Tong, A.W., Nemunaitis, J., Su, D., Zhang, Y., Cunningham, C., Senzer, N., Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): Biologic outcome in advanced cancer patients (2005) Mol Ther, 11, pp. 160-172
Yacoub, A., Mitchell, C., Brannon, J., Rosenberg, E., Qiao, L., McKinstry, R., MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity (2003) Mol Cancer Ther, 2, pp. 623-632
Zerbini, L.F., Czibere, A., Wang, Y., Correa, R.G., Otu, H., Joseph, M., A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-infammatory drug-induced apoptosis and growth arrest of cancer cells (2006) Cancer Res, 66, pp. 11922-11931
Nishikawa, T., Ramesh, R., Munshi, A., Chada, S., Meyn, R.E., Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation (2004) Mol Ther, 9, pp. 818-828
Gupta, P., Su, Z.Z., Lebedeva, I.V., Sarkar, D., Sauane, M., Emdad, L., Mda-7/IL-24: Multifunctional cancer-specifc apoptosis-inducing cytokine (2006) Pharmacol Ther, 111, pp. 596-628
Sauane, M., Su, Z.Z., Gupta, P., Lebedeva, I.V., Dent, P., Sarkar, D., Autocrine regulation of mda-7/IL-24 mediates cancer-specifc apoptosis (2008) Proc Natl Acad Sci USA, 105, pp. 9763-9768
Su, Z., Emdad, L., Sauane, M., Lebedeva, I.V., Sarkar, D., Gupta, P., Unique aspects of mda-7/IL-24 antitumor bystander activity: Establishing a role for secretion of MDA-7/IL-24 protein by normal cells (2005) Oncogene, 24, pp. 7552-7566
Beeri, R., Guerrero, J.L., Supple, G., Sullivan, S., Levine, R.A., Hajjar, R.J., New effcient catheter-based system for myocardial gene delivery (2002) Circulation, 106, pp. 1756-1759
Jiang, H., Lin, J.J., Su, Z.Z., Goldstein, N.I., Fisher, P.B., Subtraction hybridization identifes a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression (1995) Oncogene, 11, pp. 2477-2486
Jiang, H., Su, Z.Z., Lin, J.J., Goldstein, N.I., Young, C.S., Fisher, P.B., The melanoma differentiation associated gene mda-7 suppresses cancer cell growth (1996) Proc Natl Acad Sci USA, 93, pp. 9160-9165
Freytag, S.O., Stricker, H., Pegg, J., Paielli, D., Pradhan, D.G., Peabody, J., Phase i study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate-to high-risk prostate cancer (2003) Cancer Res, 63, pp. 7497-7506
Small, E.J., Carducci, M.A., Burke, J.M., Rodriguez, R., Fong, L., Van Ummersen, L., A phase i trial of intravenous CG7870, a replication-selective, prostate-specifc antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer (2006) Mol Ther, 14, pp. 107-117
Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D.D., Kirn, D.H., ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specifc cytolysis and antitumoral effcacy that can be augmented by standard chemotherapeutic agents (1997) Nat Med, 3, pp. 639-645
Su, Z.Z., Shi, Y., Fisher, P.B., Subtraction hybridization identifes a transformation progression- associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene (1997) Proc Natl Acad Sci USA, 94, pp. 9125-9130
Gao, P., Sun, X., Chen, X., Wang, Y., Foster, B.A., Subjeck, J., Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24 (2008) Cancer Res, 68, pp. 3890-3898
Yacoub, A., Hamed, H., Emdad, L., Dos Santos, W., Gupta, P., Broaddus, W.C., MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors (2008) Cancer Biol Ther, 7, pp. 917-933
Puisieux, I., Odin, L., Poujol, D., Moingeon, P., Tartaglia, J., Cox, W., Canarypox virus-mediated interleukin 12 gene transfer into murine mammary adenocarcinoma induces tumor suppression and long-term antitumoral immunity (1998) Hum Gene Ther, 9, pp. 2481-2492
Damber, J. E., Aus, G., Prostate cancer (2008) Lancet, 371, pp. 1710-172
Moon, C., Park, J. C., Chae, Y. K., Yun, J. H., Kim, S., Current status of experimental therapeutics for prostate cancer (2008) Cancer Lett, 266, pp. 116-134
Shi, X. B., Gumerlock, P. H., Devere White, R. W., Molecular biology of prostate cancer (1996) World J Urol, 14, pp. 318-328
Lebedeva, I. V., Sarkar, D., Su, Z. Z., Kitada, S., Dent, P., Stein, C. A., Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24 (2003) Oncogene, 22, pp. 8758-8773
Lebedeva, I. V., Su, Z. Z., Sarkar, D., Kitada, S., Dent, P., Waxman, S., Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species (2003) Cancer Res, 63, pp. 8138-8144
Fisher, P. B., Is mda-7/IL-24 a "magic bullet" (2005) For Cancer? Cancer Res, 65, pp. 10128-10138
Fisher, P. B., Gopalkrishnan, R. V., Chada, S., Ramesh, R., Grimm, E. A., Rosenfeld, M. R., Mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: From the laboratory into the clinic (2003) Cancer Biol Ther, 2 (4 SUPPL. 1), pp. S23-S37
Lebedeva, I. V., Emdad, L., Su, Z. Z., Gupta, P., Sauane, M., Sarkar, D., Mda-7/IL-24, novel anticancer cytokine: Focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase i clinical experience (review (2007) Int J Oncol, 31, pp. 985-1007
Howard, C. M., Forsberg, F., Minimo, C., Liu, J. B., Merton, D. A., Claudio, P. P., Ultrasound guided site specifc gene delivery system using adenoviral vectors and commercial ultrasound contrast agents (2006) J Cell Physiol, 209, pp. 413-421
Ng, K. Y., Liu, Y., Therapeutic ultrasound: Its application in drug delivery (2002) Med Res Rev, 22, pp. 204-223
Larina, I. V., Evers, B. M., Esenaliev, R. O., Optimal drug and gene delivery in cancer cells by ultrasound-induced cavitation (2005) Anticancer Res, 25 (1 A), pp. 149-156
Howard, C. M., The role of ultrasound contrast agents in gene therapy (2004) Appl Radiol, 33 (SUPPL), pp. 126-135
Goldberg, B. B., Liu, J. B., Forsberg, F., Ultrasound contrast agents: A review (1994) Ultrasound Med Biol, 20, pp. 319-333
Pitt, W. G., Husseini, G. A., Staples, B. J., Ultrasonic drug delivery\\\\\\\\\\\\\\\\-a general review (2004) Expert Opin Drug Deliv, 1, pp. 37-56
Dayton, P. A., Rychak, J. J., Molecular ultrasound imaging using microbubble contrast agents (2007) Front Biosci, 12, pp. 5124-5142
Cunningham, C. C., Chada, S., Merritt, J. A., Tong, A., Senzer, N., Zhang, Y., Clinical and local biological effects of an intratumoral injection of mda-7 (IL24
Fisher, P. B., Sarkar, D., Lebedeva, I. V., Emdad, L., Gupta, P., Sauane, M., Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): Novel gene therapeutic for metastatic melanoma (2007) Toxicol Appl Pharmacol, 224, pp. 300-307
Su, Z. Z., Madireddi, M. T., Lin, J. J., Young, C. S., Kitada, S., Reed, J. C., The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice (1998) Proc Natl Acad Sci USA, 95, pp. 14400-14405
Tong, A. W., Nemunaitis, J., Su, D., Zhang, Y., Cunningham, C., Senzer, N., Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): Biologic outcome in advanced cancer patients (2005) Mol Ther, 11, pp. 160-172
Zerbini, L. F., Czibere, A., Wang, Y., Correa, R. G., Otu, H., Joseph, M., A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-infammatory drug-induced apoptosis and growth arrest of cancer cells (2006) Cancer Res, 66, pp. 11922-11931
Gupta, P., Su, Z. Z., Lebedeva, I. V., Sarkar, D., Sauane, M., Emdad, L., Mda-7/IL-24: Multifunctional cancer-specifc apoptosis-inducing cytokine (2006) Pharmacol Ther, 111, pp. 596-628
Sauane, M., Su, Z. Z., Gupta, P., Lebedeva, I. V., Dent, P., Sarkar, D., Autocrine regulation of mda-7/IL-24 mediates cancer-specifc apoptosis (2008) Proc Natl Acad Sci USA, 105, pp. 9763-9768
Jiang, H., Lin, J. J., Su, Z. Z., Goldstein, N. I., Fisher, P. B., Subtraction hybridization identifes a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression (1995) Oncogene, 11, pp. 2477-2486
Jiang, H., Su, Z. Z., Lin, J. J., Goldstein, N. I., Young, C. S., Fisher, P. B., The melanoma differentiation associated gene mda-7 suppresses cancer cell growth (1996) Proc Natl Acad Sci USA, 93, pp. 9160-9165
Freytag, S. O., Stricker, H., Pegg, J., Paielli, D., Pradhan, D. G., Peabody, J., Phase i study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate-to high-risk prostate cancer (2003) Cancer Res, 63, pp. 7497-7506
Small, E. J., Carducci, M. A., Burke, J. M., Rodriguez, R., Fong, L., Van Ummersen, L., A phase i trial of intravenous CG7870, a replication-selective, prostate-specifc antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer (2006) Mol Ther, 14, pp. 107-117
Su, Z. Z., Shi, Y., Fisher, P. B., Subtraction hybridization identifes a transformation progression- associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene (1997) Proc Natl Acad Sci USA, 94, pp. 9125-9130
Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach
Intratumoral injections of a replication-incompetent adenovirus (Ad) expressing melanoma differentiation-associated gene-7/interleukin-24 (Ad.mda-7), a secreted cytokine displaying cancer-selective, apoptosis-inducing properties, profoundly inhibits prostate cancer (PC) growth in immune-incompetent animals. In contrast, Ad.mda-7 is ineffective in PCs overexpressing antiapoptotic proteins such as Bcl-2 or Bcl-x(L). However, intratumoral injections of a conditionally replication-competent Ad (CRCA) in which expression of the adenoviral E1A gene is driven by the cancer-specific promoter of progression-elevated gene-3 (PEG-3) and which simultaneously expresses mda-7/interleukin (IL)-24 in the E3 region of the Ad (Ad.PEG-E1A-mda-7), a cancer terminator virus (CTV), is highly active in these cells. A major challenge for gene therapy is systemic delivery of nucleic acids directly into an affected tissue. Ultrasound (US) contrast agents (microbubbles-MBs) are viable candidates for gene delivery/therapy. Here, we show that MB/Ad.mda-7 complexes targeted to DU-145 cells using US dramatically reduced tumor burden in xenografted nude mice. Additionally, US-guided MB/CTV delivery completely eradicated not only targeted DU-145/Bcl-x(L)-therapy-resistant tumors, but also nontargeted distant tumors (established in the opposite flank), thereby implementing a cure. These findings highlight potential therapeutic applications of this novel image-guided gene therapy technology for advanced PC patients with metastatic disease.
Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach
No results.
Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(295 views) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 ViewExport to BibTeXExport to EndNote