Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach (388 views)
Mol Ther (ISSN: 1525-0024e, 1525-0016linking), 2010 Feb 18; 18(2): 295-306.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Non-P. H. S,
Impact factor: 7.149, 5-year impact factor: 6.5
Url: Not available.
Keywords: Adenoviridae, Genetics, Animals, Blotting, Western, Cell Line, Tumor, Genetic Therapy, Methods, Humans, Immunohistochemistry, In Situ Nick-End Labeling, Interleukins, Physiology, Nude, Prostatic Neoplasms, Pathology,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia 25755, USA.,
References:
Damber, J.E., Aus, G., Prostate cancer (2008) Lancet, 371, pp. 1710-172
Moon, C., Park, J.C., Chae, Y.K., Yun, J.H., Kim, S., Current status of experimental therapeutics for prostate cancer (2008) Cancer Lett, 266, pp. 116-134
Shi, X.B., Gumerlock, P.H., Devere White, R.W., Molecular biology of prostate cancer (1996) World J Urol, 14, pp. 318-328
Lebedeva, I.V., Sarkar, D., Su, Z.Z., Kitada, S., Dent, P., Stein, C.A., Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24 (2003) Oncogene, 22, pp. 8758-8773
Lebedeva, I.V., Su, Z.Z., Sarkar, D., Kitada, S., Dent, P., Waxman, S., Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species (2003) Cancer Res, 63, pp. 8138-8144
Fisher, P.B., Is mda-7/IL-24 a "magic bullet" (2005) For Cancer? Cancer Res, 65, pp. 10128-10138
Fisher, P.B., Gopalkrishnan, R.V., Chada, S., Ramesh, R., Grimm, E.A., Rosenfeld, M.R., Mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: From the laboratory into the clinic (2003) Cancer Biol Ther, 2 (4 SUPPL. 1), pp. S23-S37
Lebedeva, I.V., Emdad, L., Su, Z.Z., Gupta, P., Sauane, M., Sarkar, D., Mda-7/IL-24, novel anticancer cytokine: Focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase i clinical experience (review (2007) Int J Oncol, 31, pp. 985-1007
Lebedeva, I.V., Sauane, M., Gopalkrishnan, R.V., Sarkar, D., Su, Z.Z., Gupta, P., Mda-7/IL-24: Exploiting cancer's Achilles' heel (2005) Mol Ther, 11, pp. 4-18
Sarkar, D., Dent, P., Curiel, D.T., Fisher, P.B., Acquired and innate resistance to the cancer-specifc apoptosis-inducing cytokine, mda-7/IL-24: Not insurmountable therapeutic problems (2008) Cancer Biol Ther, 7, pp. 109-112
Sarkar, D., Lebedeva, I.V., Su, Z.Z., Park, E.S., Chatman, L., Vozhilla, N., Eradication of therapy-resistant human prostate tumors using a cancer terminator virus (2007) Cancer Res, 67, pp. 5434-5442
Howard, C.M., Forsberg, F., Minimo, C., Liu, J.B., Merton, D.A., Claudio, P.P., Ultrasound guided site specifc gene delivery system using adenoviral vectors and commercial ultrasound contrast agents (2006) J Cell Physiol, 209, pp. 413-421
Jiang, H., Wang, Z., Serra, D., Frank, M.M., Amalftano, A., Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies (2004) Mol Ther, 10, pp. 1140-1142
Lawrie, A., Brisken, A.F., Francis, S.E., Cumberland, D.C., Crossman, D.C., Newman, C.M., Microbubble-enhanced ultrasound for vascular gene delivery (2000) Gene Ther, 7, pp. 2023-2027
Ng, K.Y., Liu, Y., Therapeutic ultrasound: Its application in drug delivery (2002) Med Res Rev, 22, pp. 204-223
Larina, I.V., Evers, B.M., Esenaliev, R.O., Optimal drug and gene delivery in cancer cells by ultrasound-induced cavitation (2005) Anticancer Res, 25 (1 A), pp. 149-156
Howard, C.M., The role of ultrasound contrast agents in gene therapy (2004) Appl Radiol, 33 (SUPPL), pp. 126-135
Goldberg, B.B., Liu, J.B., Forsberg, F., Ultrasound contrast agents: A review (1994) Ultrasound Med Biol, 20, pp. 319-333
Pitt, W.G., Husseini, G.A., Staples, B.J., Ultrasonic drug delivery\\\\\\\\\\\\\\\\-a general review (2004) Expert Opin Drug Deliv, 1, pp. 37-56
Dayton, P.A., Rychak, J.J., Molecular ultrasound imaging using microbubble contrast agents (2007) Front Biosci, 12, pp. 5124-5142
Cunningham, C.C., Chada, S., Merritt, J.A., Tong, A., Senzer, N., Zhang, Y., Clinical and local biological effects of an intratumoral injection of mda-7 (IL24
INGN 241) in patients with advanced carcinoma: A phase i study (2005) Mol Ther, 11, pp. 149-159
Eager, R., Harle, L., Nemunaitis, J., Ad-MDA-7
INGN 241: A review of preclinical and clinical experience (2008) Expert Opin Biol Ther, 8, pp. 1633-1643
Fisher, P.B., Sarkar, D., Lebedeva, I.V., Emdad, L., Gupta, P., Sauane, M., Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): Novel gene therapeutic for metastatic melanoma (2007) Toxicol Appl Pharmacol, 224, pp. 300-307
Inoue, S., Hartman, A., Branch, C.D., Bucana, C.D., Bekele, B.N., Stephens, L.C., Mda-7 in combination with bevacizumab treatment produces a synergistic and complete inhibitory effect on lung tumor xenograft (2007) Mol Ther, 15, pp. 287-294
Ramesh, R., Ito, I., Saito, Y., Wu, Z., Mhashikar, A.M., Wilson, D.R., Local and systemic inhibition of lung tumor growth after nanoparticle-mediated mda-7/IL-24 gene delivery (2004) DNA Cell Biol, 23, pp. 850-857
Su, Z.Z., Madireddi, M.T., Lin, J.J., Young, C.S., Kitada, S., Reed, J.C., The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice (1998) Proc Natl Acad Sci USA, 95, pp. 14400-14405
Tahara, I., Miyake, K., Hanawa, H., Kurai, T., Hirai, Y., Ishizaki, M., Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24 (2007) Mol Ther, 15, pp. 1805-1811
Tong, A.W., Nemunaitis, J., Su, D., Zhang, Y., Cunningham, C., Senzer, N., Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): Biologic outcome in advanced cancer patients (2005) Mol Ther, 11, pp. 160-172
Yacoub, A., Mitchell, C., Brannon, J., Rosenberg, E., Qiao, L., McKinstry, R., MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity (2003) Mol Cancer Ther, 2, pp. 623-632
Zerbini, L.F., Czibere, A., Wang, Y., Correa, R.G., Otu, H., Joseph, M., A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-infammatory drug-induced apoptosis and growth arrest of cancer cells (2006) Cancer Res, 66, pp. 11922-11931
Nishikawa, T., Ramesh, R., Munshi, A., Chada, S., Meyn, R.E., Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation (2004) Mol Ther, 9, pp. 818-828
Gupta, P., Su, Z.Z., Lebedeva, I.V., Sarkar, D., Sauane, M., Emdad, L., Mda-7/IL-24: Multifunctional cancer-specifc apoptosis-inducing cytokine (2006) Pharmacol Ther, 111, pp. 596-628
Sauane, M., Su, Z.Z., Gupta, P., Lebedeva, I.V., Dent, P., Sarkar, D., Autocrine regulation of mda-7/IL-24 mediates cancer-specifc apoptosis (2008) Proc Natl Acad Sci USA, 105, pp. 9763-9768
Su, Z., Emdad, L., Sauane, M., Lebedeva, I.V., Sarkar, D., Gupta, P., Unique aspects of mda-7/IL-24 antitumor bystander activity: Establishing a role for secretion of MDA-7/IL-24 protein by normal cells (2005) Oncogene, 24, pp. 7552-7566
Beeri, R., Guerrero, J.L., Supple, G., Sullivan, S., Levine, R.A., Hajjar, R.J., New effcient catheter-based system for myocardial gene delivery (2002) Circulation, 106, pp. 1756-1759
Jiang, H., Lin, J.J., Su, Z.Z., Goldstein, N.I., Fisher, P.B., Subtraction hybridization identifes a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression (1995) Oncogene, 11, pp. 2477-2486
Jiang, H., Su, Z.Z., Lin, J.J., Goldstein, N.I., Young, C.S., Fisher, P.B., The melanoma differentiation associated gene mda-7 suppresses cancer cell growth (1996) Proc Natl Acad Sci USA, 93, pp. 9160-9165
Freytag, S.O., Stricker, H., Pegg, J., Paielli, D., Pradhan, D.G., Peabody, J., Phase i study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate-to high-risk prostate cancer (2003) Cancer Res, 63, pp. 7497-7506
Small, E.J., Carducci, M.A., Burke, J.M., Rodriguez, R., Fong, L., Van Ummersen, L., A phase i trial of intravenous CG7870, a replication-selective, prostate-specifc antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer (2006) Mol Ther, 14, pp. 107-117
Heise, C., Sampson-Johannes, A., Williams, A., McCormick, F., Von Hoff, D.D., Kirn, D.H., ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specifc cytolysis and antitumoral effcacy that can be augmented by standard chemotherapeutic agents (1997) Nat Med, 3, pp. 639-645
Su, Z.Z., Shi, Y., Fisher, P.B., Subtraction hybridization identifes a transformation progression- associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene (1997) Proc Natl Acad Sci USA, 94, pp. 9125-9130
Gao, P., Sun, X., Chen, X., Wang, Y., Foster, B.A., Subjeck, J., Secretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24 (2008) Cancer Res, 68, pp. 3890-3898
Yacoub, A., Hamed, H., Emdad, L., Dos Santos, W., Gupta, P., Broaddus, W.C., MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors (2008) Cancer Biol Ther, 7, pp. 917-933
Puisieux, I., Odin, L., Poujol, D., Moingeon, P., Tartaglia, J., Cox, W., Canarypox virus-mediated interleukin 12 gene transfer into murine mammary adenocarcinoma induces tumor suppression and long-term antitumoral immunity (1998) Hum Gene Ther, 9, pp. 2481-2492
Damber, J. E., Aus, G., Prostate cancer (2008) Lancet, 371, pp. 1710-172
Moon, C., Park, J. C., Chae, Y. K., Yun, J. H., Kim, S., Current status of experimental therapeutics for prostate cancer (2008) Cancer Lett, 266, pp. 116-134
Shi, X. B., Gumerlock, P. H., Devere White, R. W., Molecular biology of prostate cancer (1996) World J Urol, 14, pp. 318-328
Lebedeva, I. V., Sarkar, D., Su, Z. Z., Kitada, S., Dent, P., Stein, C. A., Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24 (2003) Oncogene, 22, pp. 8758-8773
Lebedeva, I. V., Su, Z. Z., Sarkar, D., Kitada, S., Dent, P., Waxman, S., Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species (2003) Cancer Res, 63, pp. 8138-8144
Fisher, P. B., Is mda-7/IL-24 a "magic bullet" (2005) For Cancer? Cancer Res, 65, pp. 10128-10138
Fisher, P. B., Gopalkrishnan, R. V., Chada, S., Ramesh, R., Grimm, E. A., Rosenfeld, M. R., Mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: From the laboratory into the clinic (2003) Cancer Biol Ther, 2 (4 SUPPL. 1), pp. S23-S37
Lebedeva, I. V., Emdad, L., Su, Z. Z., Gupta, P., Sauane, M., Sarkar, D., Mda-7/IL-24, novel anticancer cytokine: Focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase i clinical experience (review (2007) Int J Oncol, 31, pp. 985-1007
Howard, C. M., Forsberg, F., Minimo, C., Liu, J. B., Merton, D. A., Claudio, P. P., Ultrasound guided site specifc gene delivery system using adenoviral vectors and commercial ultrasound contrast agents (2006) J Cell Physiol, 209, pp. 413-421
Ng, K. Y., Liu, Y., Therapeutic ultrasound: Its application in drug delivery (2002) Med Res Rev, 22, pp. 204-223
Larina, I. V., Evers, B. M., Esenaliev, R. O., Optimal drug and gene delivery in cancer cells by ultrasound-induced cavitation (2005) Anticancer Res, 25 (1 A), pp. 149-156
Howard, C. M., The role of ultrasound contrast agents in gene therapy (2004) Appl Radiol, 33 (SUPPL), pp. 126-135
Goldberg, B. B., Liu, J. B., Forsberg, F., Ultrasound contrast agents: A review (1994) Ultrasound Med Biol, 20, pp. 319-333
Pitt, W. G., Husseini, G. A., Staples, B. J., Ultrasonic drug delivery\\\\\\\\\\\\\\\\-a general review (2004) Expert Opin Drug Deliv, 1, pp. 37-56
Dayton, P. A., Rychak, J. J., Molecular ultrasound imaging using microbubble contrast agents (2007) Front Biosci, 12, pp. 5124-5142
Cunningham, C. C., Chada, S., Merritt, J. A., Tong, A., Senzer, N., Zhang, Y., Clinical and local biological effects of an intratumoral injection of mda-7 (IL24
Fisher, P. B., Sarkar, D., Lebedeva, I. V., Emdad, L., Gupta, P., Sauane, M., Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): Novel gene therapeutic for metastatic melanoma (2007) Toxicol Appl Pharmacol, 224, pp. 300-307
Su, Z. Z., Madireddi, M. T., Lin, J. J., Young, C. S., Kitada, S., Reed, J. C., The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice (1998) Proc Natl Acad Sci USA, 95, pp. 14400-14405
Tong, A. W., Nemunaitis, J., Su, D., Zhang, Y., Cunningham, C., Senzer, N., Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): Biologic outcome in advanced cancer patients (2005) Mol Ther, 11, pp. 160-172
Zerbini, L. F., Czibere, A., Wang, Y., Correa, R. G., Otu, H., Joseph, M., A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-infammatory drug-induced apoptosis and growth arrest of cancer cells (2006) Cancer Res, 66, pp. 11922-11931
Gupta, P., Su, Z. Z., Lebedeva, I. V., Sarkar, D., Sauane, M., Emdad, L., Mda-7/IL-24: Multifunctional cancer-specifc apoptosis-inducing cytokine (2006) Pharmacol Ther, 111, pp. 596-628
Sauane, M., Su, Z. Z., Gupta, P., Lebedeva, I. V., Dent, P., Sarkar, D., Autocrine regulation of mda-7/IL-24 mediates cancer-specifc apoptosis (2008) Proc Natl Acad Sci USA, 105, pp. 9763-9768
Jiang, H., Lin, J. J., Su, Z. Z., Goldstein, N. I., Fisher, P. B., Subtraction hybridization identifes a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression (1995) Oncogene, 11, pp. 2477-2486
Jiang, H., Su, Z. Z., Lin, J. J., Goldstein, N. I., Young, C. S., Fisher, P. B., The melanoma differentiation associated gene mda-7 suppresses cancer cell growth (1996) Proc Natl Acad Sci USA, 93, pp. 9160-9165
Freytag, S. O., Stricker, H., Pegg, J., Paielli, D., Pradhan, D. G., Peabody, J., Phase i study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate-to high-risk prostate cancer (2003) Cancer Res, 63, pp. 7497-7506
Small, E. J., Carducci, M. A., Burke, J. M., Rodriguez, R., Fong, L., Van Ummersen, L., A phase i trial of intravenous CG7870, a replication-selective, prostate-specifc antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer (2006) Mol Ther, 14, pp. 107-117
Su, Z. Z., Shi, Y., Fisher, P. B., Subtraction hybridization identifes a transformation progression- associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene (1997) Proc Natl Acad Sci USA, 94, pp. 9125-9130
Mol Ther (ISSN: 1525-0024e, 1525-0016linking), 2010 Feb 18; 18(2): 295-306.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Non-P. H. S,
Impact factor: 7.149, 5-year impact factor: 6.5
Url: Not available.
Keywords: Adenoviridae, Genetics, Animals, Blotting, Western, Cell Line, Tumor, Genetic Therapy, Methods, Humans, Immunohistochemistry, In Situ Nick-End Labeling, Interleukins, Physiology, Nude, Prostatic Neoplasms, Pathology,
Affiliations:
*** IBB - CNR ***
Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia 25755, USA.,
References:
Damber, J.E., Aus, G., Prostate cancer (2008) Lancet, 371, pp. 1710-172
Moon, C., Park, J.C., Chae, Y.K., Yun, J.H., Kim, S., Current status of experimental therapeutics for prostate cancer (2008) Cancer Lett, 266, pp. 116-134
Shi, X.B., Gumerlock, P.H., Devere White, R.W., Molecular biology of prostate cancer (1996) World J Urol, 14, pp. 318-328
Lebedeva, I.V., Sarkar, D., Su, Z.Z., Kitada, S., Dent, P., Stein, C.A., Bcl-2 and Bcl-xL differentially protect human prostate cancer cells from induction of apoptosis by melanoma differentiation associated gene-7, mda-7/IL-24 (2003) Oncogene, 22, pp. 8758-8773
Lebedeva, I.V., Su, Z.Z., Sarkar, D., Kitada, S., Dent, P., Waxman, S., Melanoma differentiation associated gene-7, mda-7/interleukin-24, induces apoptosis in prostate cancer cells by promoting mitochondrial dysfunction and inducing reactive oxygen species (2003) Cancer Res, 63, pp. 8138-8144
Fisher, P.B., Is mda-7/IL-24 a "magic bullet" (2005) For Cancer? Cancer Res, 65, pp. 10128-10138
Fisher, P.B., Gopalkrishnan, R.V., Chada, S., Ramesh, R., Grimm, E.A., Rosenfeld, M.R., Mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: From the laboratory into the clinic (2003) Cancer Biol Ther, 2 (4 SUPPL. 1), pp. S23-S37
Lebedeva, I.V., Emdad, L., Su, Z.Z., Gupta, P., Sauane, M., Sarkar, D., Mda-7/IL-24, novel anticancer cytokine: Focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase i clinical experience (review (2007) Int J Oncol, 31, pp. 985-1007
Lebedeva, I.V., Sauane, M., Gopalkrishnan, R.V., Sarkar, D., Su, Z.Z., Gupta, P., Mda-7/IL-24: Exploiting cancer's Achilles' heel (2005) Mol Ther, 11, pp. 4-18
Sarkar, D., Dent, P., Curiel, D.T., Fisher, P.B., Acquired and innate resistance to the cancer-specifc apoptosis-inducing cytokine, mda-7/IL-24: Not insurmountable therapeutic problems (2008) Cancer Biol Ther, 7, pp. 109-112
Sarkar, D., Lebedeva, I.V., Su, Z.Z., Park, E.S., Chatman, L., Vozhilla, N., Eradication of therapy-resistant human prostate tumors using a cancer terminator virus (2007) Cancer Res, 67, pp. 5434-5442
Howard, C.M., Forsberg, F., Minimo, C., Liu, J.B., Merton, D.A., Claudio, P.P., Ultrasound guided site specifc gene delivery system using adenoviral vectors and commercial ultrasound contrast agents (2006) J Cell Physiol, 209, pp. 413-421
Jiang, H., Wang, Z., Serra, D., Frank, M.M., Amalftano, A., Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies (2004) Mol Ther, 10, pp. 1140-1142
Lawrie, A., Brisken, A.F., Francis, S.E., Cumberland, D.C., Crossman, D.C., Newman, C.M., Microbubble-enhanced ultrasound for vascular gene delivery (2000) Gene Ther, 7, pp. 2023-2027
Ng, K.Y., Liu, Y., Therapeutic ultrasound: Its application in drug delivery (2002) Med Res Rev, 22, pp. 204-223
Larina, I.V., Evers, B.M., Esenaliev, R.O., Optimal drug and gene delivery in cancer cells by ultrasound-induced cavitation (2005) Anticancer Res, 25 (1 A), pp. 149-156
Howard, C.M., The role of ultrasound contrast agents in gene therapy (2004) Appl Radiol, 33 (SUPPL), pp. 126-135
Goldberg, B.B., Liu, J.B., Forsberg, F., Ultrasound contrast agents: A review (1994) Ultrasound Med Biol, 20, pp. 319-333
Pitt, W.G., Husseini, G.A., Staples, B.J., Ultrasonic drug delivery\\\\\\\\\\\\\\\\-a general review (2004) Expert Opin Drug Deliv, 1, pp. 37-56
Dayton, P.A., Rychak, J.J., Molecular ultrasound imaging using microbubble contrast agents (2007) Front Biosci, 12, pp. 5124-5142
Cunningham, C.C., Chada, S., Merritt, J.A., Tong, A., Senzer, N., Zhang, Y., Clinical and local biological effects of an intratumoral injection of mda-7 (IL24
INGN 241) in patients with advanced carcinoma: A phase i study (2005) Mol Ther, 11, pp. 149-159
Eager, R., Harle, L., Nemunaitis, J., Ad-MDA-7
INGN 241: A review of preclinical and clinical experience (2008) Expert Opin Biol Ther, 8, pp. 1633-1643
Fisher, P.B., Sarkar, D., Lebedeva, I.V., Emdad, L., Gupta, P., Sauane, M., Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): Novel gene therapeutic for metastatic melanoma (2007) Toxicol Appl Pharmacol, 224, pp. 300-307
Inoue, S., Hartman, A., Branch, C.D., Bucana, C.D., Bekele, B.N., Stephens, L.C., Mda-7 in combination with bevacizumab treatment produces a synergistic and complete inhibitory effect on lung tumor xenograft (2007) Mol Ther, 15, pp. 287-294
Ramesh, R., Ito, I., Saito, Y., Wu, Z., Mhashikar, A.M., Wilson, D.R., Local and systemic inhibition of lung tumor growth after nanoparticle-mediated mda-7/IL-24 gene delivery (2004) DNA Cell Biol, 23, pp. 850-857
Su, Z.Z., Madireddi, M.T., Lin, J.J., Young, C.S., Kitada, S., Reed, J.C., The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice (1998) Proc Natl Acad Sci USA, 95, pp. 14400-14405
Tahara, I., Miyake, K., Hanawa, H., Kurai, T., Hirai, Y., Ishizaki, M., Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24 (2007) Mol Ther, 15, pp. 1805-1811
Tong, A.W., Nemunaitis, J., Su, D., Zhang, Y., Cunningham, C., Senzer, N., Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): Biologic outcome in advanced cancer patients (2005) Mol Ther, 11, pp. 160-172
Yacoub, A., Mitchell, C., Brannon, J., Rosenberg, E., Qiao, L., McKinstry, R., MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity (2003) Mol Cancer Ther, 2, pp. 623-632
Zerbini, L.F., Czibere, A., Wang, Y., Correa, R.G., Otu, H., Joseph, M., A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-infammatory drug-induced apoptosis and growth arrest of cancer cells (2006) Cancer Res, 66, pp. 11922-11931
Nishikawa, T., Ramesh, R., Munshi, A., Chada, S., Meyn, R.E., Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation (2004) Mol Ther, 9, pp. 818-828
Gupta, P., Su, Z.Z., Lebedeva, I.V., Sarkar, D., Sauane, M., Emdad, L., Mda-7/IL-24: Multifunctional cancer-specifc apoptosis-inducing cytokine (2006) Pharmacol Ther, 111, pp. 596-628
Sauane, M., Su, Z.Z., Gupta, P., Lebedeva, I.V., Dent, P., Sarkar, D., Autocrine regulation of mda-7/IL-24 mediates cancer-specifc apoptosis (2008) Proc Natl Acad Sci USA, 105, pp. 9763-9768
Su, Z., Emdad, L., Sauane, M., Lebedeva, I.V., Sarkar, D., Gupta, P., Unique aspects of mda-7/IL-24 antitumor bystander activity: Establishing a role for secretion of MDA-7/IL-24 protein by normal cells (2005) Oncogene, 24, pp. 7552-7566
Beeri, R., Guerrero, J.L., Supple, G., Sullivan, S., Levine, R.A., Hajjar, R.J., New effcient catheter-based system for myocardial gene delivery (2002) Circulation, 106, pp. 1756-1759
Jiang, H., Lin, J.J., Su, Z.Z., Goldstein, N.I., Fisher, P.B., Subtraction hybridization identifes a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression (1995) Oncogene, 11, pp. 2477-2486
Jiang, H., Su, Z.Z., Lin, J.J., Goldstein, N.I., Young, C.S., Fisher, P.B., The melanoma differentiation associated gene mda-7 suppresses cancer cell growth (1996) Proc Natl Acad Sci USA, 93, pp. 9160-9165
Freytag, S.O., Stricker, H., Pegg, J., Paielli, D., Pradhan, D.G., Peabody, J., Phase i study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate-to high-risk prostate cancer (2003) Cancer Res, 63, pp. 7497-7506
Small, E.J., Carducci, M.A., Burke, J.M., Rodriguez, R., Fong, L., Van Ummersen, L., A phase i trial of intravenous CG7870, a replication-selective, prostate-specifc antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer (2006) Mol Ther, 14, pp. 107-117
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Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach
Intratumoral injections of a replication-incompetent adenovirus (Ad) expressing melanoma differentiation-associated gene-7/interleukin-24 (Ad.mda-7), a secreted cytokine displaying cancer-selective, apoptosis-inducing properties, profoundly inhibits prostate cancer (PC) growth in immune-incompetent animals. In contrast, Ad.mda-7 is ineffective in PCs overexpressing antiapoptotic proteins such as Bcl-2 or Bcl-x(L). However, intratumoral injections of a conditionally replication-competent Ad (CRCA) in which expression of the adenoviral E1A gene is driven by the cancer-specific promoter of progression-elevated gene-3 (PEG-3) and which simultaneously expresses mda-7/interleukin (IL)-24 in the E3 region of the Ad (Ad.PEG-E1A-mda-7), a cancer terminator virus (CTV), is highly active in these cells. A major challenge for gene therapy is systemic delivery of nucleic acids directly into an affected tissue. Ultrasound (US) contrast agents (microbubbles-MBs) are viable candidates for gene delivery/therapy. Here, we show that MB/Ad.mda-7 complexes targeted to DU-145 cells using US dramatically reduced tumor burden in xenografted nude mice. Additionally, US-guided MB/CTV delivery completely eradicated not only targeted DU-145/Bcl-x(L)-therapy-resistant tumors, but also nontargeted distant tumors (established in the opposite flank), thereby implementing a cure. These findings highlight potential therapeutic applications of this novel image-guided gene therapy technology for advanced PC patients with metastatic disease.
Intratumoral injections of a replication-incompetent adenovirus (Ad) expressing melanoma differentiation-associated gene-7/interleukin-24 (Ad.mda-7), a secreted cytokine displaying cancer-selective, apoptosis-inducing properties, profoundly inhibits prostate cancer (PC) growth in immune-incompetent animals. In contrast, Ad.mda-7 is ineffective in PCs overexpressing antiapoptotic proteins such as Bcl-2 or Bcl-x(L). However, intratumoral injections of a conditionally replication-competent Ad (CRCA) in which expression of the adenoviral E1A gene is driven by the cancer-specific promoter of progression-elevated gene-3 (PEG-3) and which simultaneously expresses mda-7/interleukin (IL)-24 in the E3 region of the Ad (Ad.PEG-E1A-mda-7), a cancer terminator virus (CTV), is highly active in these cells. A major challenge for gene therapy is systemic delivery of nucleic acids directly into an affected tissue. Ultrasound (US) contrast agents (microbubbles-MBs) are viable candidates for gene delivery/therapy. Here, we show that MB/Ad.mda-7 complexes targeted to DU-145 cells using US dramatically reduced tumor burden in xenografted nude mice. Additionally, US-guided MB/CTV delivery completely eradicated not only targeted DU-145/Bcl-x(L)-therapy-resistant tumors, but also nontargeted distant tumors (established in the opposite flank), thereby implementing a cure. These findings highlight potential therapeutic applications of this novel image-guided gene therapy technology for advanced PC patients with metastatic disease.
Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach
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Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach
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Squillacioti C, Pelagalli A, De Luca A, Liguori G, Ali S, Mirabella N
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Insabato L, Guadagno E, Natella V, Somma A, Bihl M, Pizzolorusso A, Mainenti PP, Apice G, Tornillo L
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
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Formicola F, Riccardi A, Vigliar E, Biondi B, Accurso A, Del Vecchio W, Imbriaco M
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Natella V, Merolla F, Giampaolino P, Bifulco G, Mainenti PP, Insabato L
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
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Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
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Impact Factor: 7.581
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (426 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (341 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (437 views)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
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Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
* Usefulness of [(111)In-DTPA(0)] octreotide scintigraphy in a family with von Hippel-Lindau disease (341 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2008 Apr; 31(4): 352-359.
Impact Factor: 1.888
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (471 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (419 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (407 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (533 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (410 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
* Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (320 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Impact Factor: 1.496
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (306 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (320 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (429 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (512 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Monfrecola G, Procaccini EM, D'Onofrio D, Roberti G, Liuzzi R, Staibano S, Manco A, De Rosa G, Santoianni P
* Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light (438 views)
J Photochem Photobiol B (ISSN: 1011-1344, 1011-1344print, 1011-1344linking), 2002 Nov; 68(2-3): 147-155.
Impact Factor: 1.573
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (492 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (437 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Caprio MG, Carbone G, Bracigliano A, Acampa W, Mainolfi C, Molea G, Salvatore M
* Sentinel lymph node detection by lymphoscintigraphy in malignant melanoma (299 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S43-S43.
Impact Factor: 0.267
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Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (232 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (409 views)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (451 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (260 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (423 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (456 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Maurea S, Lastoria S, Klain M, Brunetti A, Boscaino A, Lupoli G, Salvatore M
Diagnostic evaluation of thyroid involvement by histiocytosis (270 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Feb; 35(2): 263-265.
Impact Factor: 3.491
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Lauro GM, Fonti R, Margotta V
Phylogenetic evolution of intermediate filament associated proteins in ependymal cells of several adult poikilotherm vertebrates (384 views)
Journal Fur Hirnforschung (ISSN: 0021-8359), 1991; 32(2): 257-261.
Impact Factor: 0
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Margotta V, Fonti R, Palladini G, Filoni S, Lauro GM
Transient expression of glial-fibrillary acidic protein (GFAP) in the ependyma of the regenerating spinal cord in adult newts (383 views)
Journal Fur Hirnforschung (ISSN: 0021-8359), 1991; 32(4): 485-490.
Impact Factor: 0
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (324 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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* Urocortinergic system in the epididymis of the normal and cryptorchid dogs (193 views)
Reprod Domest Anim (ISSN: 0936-6768linking), 2019 Apr 20; N/D: N/D-N/D.
Impact Factor: 1.638
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La Manna S, Scognamiglio PL, Di Natale C, Leone M, Mercurio FA, Malfitano AM, Cianfarani F, Madonna S, Caravella S, Albanesi C, Novellino E, Marasco D
* Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces (383 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2017 May 04; 138: 106-115.
Impact Factor: 3.188
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Gargiulo S, Anzilotti S, Coda AR, Gramanzini M, Greco A, Panico M, Vinciguerra A, Zannetti A, Vicidomini C, Dolle F, Pignataro G, Quarantelli M, Annunziato L, Brunetti A, Salvatore M, Pappata S
* Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT (773 views) (PDF 297 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Jan 27; 43(7): 1348-1359.
Impact Factor: 7.277
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Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz HJ, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH
* Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke (302 views)
J Cerebr Blood F Met (ISSN: 0271-678x), 2015 Nov; 35(11): 1711-1721.
Impact Factor: 4.929
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Insabato L, Guadagno E, Natella V, Somma A, Bihl M, Pizzolorusso A, Mainenti PP, Apice G, Tornillo L
* An unusual association of malignant gastrointestinal neuroectodermal tumor (clear cell sarcoma-like) and Ewing sarcoma (258 views)
Pathol Res Pract (ISSN: 0344-0338), 2015 Sep; 211(9): 688-692.
Impact Factor: 1.388
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
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N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (541 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Romeo V, Esposito A, Maurea S, Camera L, Mainenti PP, Palmieri G, Buonerba C, Salvatore M
* Correlative Imaging in a Patient with Cystic Thymoma: CT, MR and PET/CT Comparison (357 views)
Pol J Radiol (ISSN: 0137-7183, 1733-134x, 1733-134xlinking), 2015 Jan 13; 80(1): 22-26.
Impact Factor: 0.567
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (437 views)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (478 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (523 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Formicola F, Riccardi A, Vigliar E, Biondi B, Accurso A, Del Vecchio W, Imbriaco M
* Multimetastatic medullary thyroid carcinoma to the breast: PET/CT--mammographic-US and MR findings (245 views)
Breast J (ISSN: 1075-122x), 2014 Nov; 20(6): 653-654.
Impact Factor: 1.411
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (405 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
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Natella V, Merolla F, Giampaolino P, Bifulco G, Mainenti PP, Insabato L
* A huge malignant perivascular epithelioid cell tumor (PEComa) of the uterine cervix and vagina (357 views)
Pathol Res Pract (ISSN: 0344-0338), 2014 Mar; 210(3): 186-188.
Impact Factor: 1.397
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D'Arco F, Pizzuti LM, Romano F, Natella V, Laccetti E, Storto G, Maurea S, Mainenti PP
* MRI findings of a remote and isolated vaginal metastasis revealing an adenocarcinoma of the mid-sigmoid colon (263 views)
Pol J Radiol (ISSN: 1733-134x, 0137-7183, 1733-134xlinking), 2014 Feb 18; 79: 33-35.
Impact Factor: 0.567
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Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (525 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (554 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (436 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (413 views) (PDF 240 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Apr 4; 4(6): e578-e578.
Impact Factor: 5.333
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Carotenuto M, Pedone E, Diana D, de Antonellis P, Džeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M
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Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2013 Mar 1; 3: 1351-1351.
Impact Factor: 5.078
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (630 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (475 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
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Poletto M, Di Loreto C, Marasco D, Poletto E, Puglisi F, Damante G, Tell G
* Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers (455 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x), 2012 Jul 20; 424(1): 34-39.
Impact Factor: 2.406
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (586 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (495 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (395 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (399 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (562 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (529 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (575 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (397 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
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Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G
* Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-κB-Dependent hypertrophic gene expression (378 views)
Hypertensionhypertension (ISSN: 0194-911x), 2010; 56(4): 696-704.
Impact Factor: 6.908
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Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E
* Carnosinase levels in aging brain: redox state induction and cellular stress response (356 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Impact Factor: 7.581
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (426 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (341 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (437 views)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
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Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
* Usefulness of [(111)In-DTPA(0)] octreotide scintigraphy in a family with von Hippel-Lindau disease (341 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2008 Apr; 31(4): 352-359.
Impact Factor: 1.888
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (471 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (419 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (407 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (533 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (410 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
* Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (320 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Impact Factor: 1.496
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Penolazzi L, Borgatti M, Lambertini E, Mischiati C, Finotti A, Romanelli A, Saviano M, Pedone C, Piva R, Gambari R
* Peptide nucleic acid-DNA decoy chimeras targeting NF-kappa B transcription factors: Induction of apoptosis in human primary osteoclasts (306 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2004 Sep; 14(2): 145-152.
Impact Factor: 3.19
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (320 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (429 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (512 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Monfrecola G, Procaccini EM, D'Onofrio D, Roberti G, Liuzzi R, Staibano S, Manco A, De Rosa G, Santoianni P
* Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light (438 views)
J Photochem Photobiol B (ISSN: 1011-1344, 1011-1344print, 1011-1344linking), 2002 Nov; 68(2-3): 147-155.
Impact Factor: 1.573
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (492 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (437 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Caprio MG, Carbone G, Bracigliano A, Acampa W, Mainolfi C, Molea G, Salvatore M
* Sentinel lymph node detection by lymphoscintigraphy in malignant melanoma (299 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S43-S43.
Impact Factor: 0.267
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Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (232 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
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Romanelli A, Pedone C, Saviano M, Bianchi N, Borgatti M, Mischiati C, Gambari R
* Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites (409 views)
Eur J Biochem (ISSN: 0014-2956print, 0014-2956linking), 2001 Dec; 268(23): 6066-6075.
Impact Factor: 4.779
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (451 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (260 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (423 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (456 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Maurea S, Lastoria S, Klain M, Brunetti A, Boscaino A, Lupoli G, Salvatore M
Diagnostic evaluation of thyroid involvement by histiocytosis (270 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Feb; 35(2): 263-265.
Impact Factor: 3.491
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Lauro GM, Fonti R, Margotta V
Phylogenetic evolution of intermediate filament associated proteins in ependymal cells of several adult poikilotherm vertebrates (384 views)
Journal Fur Hirnforschung (ISSN: 0021-8359), 1991; 32(2): 257-261.
Impact Factor: 0
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Margotta V, Fonti R, Palladini G, Filoni S, Lauro GM
Transient expression of glial-fibrillary acidic protein (GFAP) in the ependyma of the regenerating spinal cord in adult newts (383 views)
Journal Fur Hirnforschung (ISSN: 0021-8359), 1991; 32(4): 485-490.
Impact Factor: 0
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (324 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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61 Records (52 excluding Abstracts).
Total impact factor: 335.059 (304.173 excluding Abstracts).
Total 5 year impact factor: 337.393 (303.82 excluding Abstracts).
Total impact factor: 335.059 (304.173 excluding Abstracts).
Total 5 year impact factor: 337.393 (303.82 excluding Abstracts).
388 views. Last view on Saturday 05 November 2022, 9:15:35
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