Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure(309 views) Nappi A, Cuocolo A, Imbriaco M, Nicolai E, Varrone A, Morisco C, Romano M, Trimarco B, Salvatore M
Affiliations: Ctro. per la Med. Nucleare del CNR, Università Federico II, Via Pansini, 5, 8013 Napoli, Italy
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Knox, A. J., Morrison, J. F. J., Muers, M. F., Reproducibility of walking test results in chronic obstructive airways disease (1988) Thorax, 43, pp. 388-392
Guyatt, G. H., Sullivan, M. J., Thompson, P. J., The 6-min walk: A new measure of exercise capacity in patients with chronic heart failure (1985) Can Med Assoc J, 132, pp. 919-923
Lipkin, D. P., Scriven, A. J., Crake, T., Poole-Wilson, P. A., Six-minute walking test for assessing exercise capacity in chronic heart failure (1988) Br Med J, 292, pp. 653-655
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Weber, K. T., Janicky, J. S., Cardiopulmonary exercise testing for evaluation of chronic cardiac failure (1985) Am J Cardiol, 55, pp. 22A-31A
Nemanich, J. W., Shurman, A. J., Rossen, J. D., Kremser, C., Davis, F., Rajfer, S. I., Effects of long-term therapy with oral piroximone on resting hemodynamics, peak aerobic capacity and the anaerobic threshold in patients with heart failure (1987) J Cardiovasc Pharmacol, 10, pp. 580-588
Gladden, L. B., Yates, J. W., Stremel, R. W., Stamford, B. A., Gas exchange and lactate anaerobic thresholds: Inter- and intra-evaluator agreement (1985) J Appl Physiol, 58, pp. 2082-2089
Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure
The aim of this study was to assess changes in left ventricular (LV) function during 6-min walk test and cardiopulmonary exercise by continuous radionuclide monitoring in patients with congestive heart failure (CHF). Methods: Seventeen patients with CHF and 10 normal subjects underwent monitoring of LV function (Vest) during 6-min walk test and during bicycle exercise with combined analysis of pulmonary gas exchange. During cardiopulmonary exercise, all parameters of LV function were measured at rest, at the anaerobic threshold (AT) and al peak oxygen uptake (peak VO2). Results: In the normal subjects, during the walk test, heart rate (HR), ejection fraction (EF), end-diastolic volume (EDV), cardiac output (CO) and stroke volume (SV) significantly increased from rest to peak (all p < 0.001), while end-systolic volume (ESV) significantly decreased from rest to peak (p < 0.001). In patients with CHF, during the walk test, HR, EDV, ESV and CO significantly increased from rest to peak (p < 0.001), EF significantly decreased from rest to peak (p < 0.001) and SV did not show significant change. During cardiopulmonary exercise, normal subjects showed a significant increase in HR and CO, from rest to AT and from AT to the peak VO2 (p < 0.001). EF, EDV and SV significantly increased from rest to AT (p < 0.001), with no significant change from AT to peak VO2. ESV decreased from rest to AT (p < 0.001), showing no significant change from AT to peak VO2, In patients with CHF, HR, CO, ESV and EDV increased significantly from rest to AT (p < 0.001) and from AT to peak VO2 (p < 0.001), EF and SV did not show significant changes from rest to AT, showing a significant decrease from AT to peak VO2 (p < 0.001), Conclusion: Vest can be used to evaluate cardiac responses during 6-min walk test and cardiopulmonary exercise in patients with CHF. In such patients, significant impairment of LV function is already present during submaximal physical exercise becoming more evident during the anaerobic phases of bicycle exercise.
Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure