Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions(296 views) Imbriaco M, Caprio MG, Limite G, Pace L, De Falco T, Capuano E, Salvatore M
Keywords: Breast Carcinoma, Fdg Pet, Pet Ct, Fluorodeoxyglucose F 18, Gadolinium, Gadolinium Pentetate, Adult, Article, Body Posture, Breast Tumor, Comparative Study, Computer Assisted Emission Tomography, Diagnostic Accuracy, Diagnostic Imaging, Histopathology, Human, Major Clinical Study, Mammography, Nuclear Magnetic Resonance Imaging, Priority Journal, Sensitivity And Specificity, Breast Neoplasms, Female, Magnetic Resonance Spectroscopy, Middle Aged, Positron-Emission Tomography, Radiopharmaceuticals, Reproducibility Of Results, X-Ray Computed,
Affiliations: *** IBB - CNR ***
Dipartimento di Scienze Biomorfologiche e Funzionali, Universita degli Studi di Napoli Federico II, Via Posillipo 196, 80123, Naples, Italy. mimbriaco@hotmail.com
National Research Council Napoli, Institute of Bio-structure and Bio-imaging, SDN Foundation, Naples, Italy
Dipartimento di Chirurgia, Università degli Studi di Napoli Federico II, Naples, Italy
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Eubank, W. B., Mankoff, D. A., Evolving role of positron emission tomography in breast cancer imaging (2005) Semin Nucl Med, 35, pp. 84-99
Schnall, M. D., Blume, J., Bluemke, D. A., Diagnostic architectural and dynamic features at breast MR imaging: Multicenter study (2006) Radiology, 238, pp. 42-53
Lehman, C. D., Gatsonis, C., Kuhl, C. K., MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer (2007) N Engl J Med, 356, pp. 1295-1303
Kuhl, C. K., Current status of breast MR imaging. Part 2. Clinical applications (2007) Radiology, 244, pp. 672-691
Morris, E. A., Diagnostic breast MR imaging: Current status and future directions (2007) Radiol Clin North Am, 45, pp. 863-880
Peters, N. H., Borel-Rinkes, I. H., Zuithoff, N. P., Mali, W. P., Moons, K. G., Peeters, P. H., Meta-analysis of MR imaging in the diagnosis of breast lesions (2008) Radiology, 246, pp. 116-124
(1995) Breast imaging reporting and data system, , American College of Radiology ACR, BI-RADS, 2nd ed. Reston, VA: American College of Radiology
(1998) Radiation dose to patients from radiopharmaceuticals, , International Commission on Radiological Protection, Publication 80. New York, NY: ICRP
Kuhl, C. K., Schild, H. H., Morakkabati, N., Dynamic bilateral contrast-enhanced MR imaging of the breast: Trade-off between spatial and temporal resolution (2005) Radiology, 236, pp. 789-800
Stack, J. P., Redmond, O. M., Codd, M. B., Dervan, P. A., Ennis, J. T., Breast disease: Tissue characterization with Gd-DTPA enhancement profiles (1990) Radiology, 174, pp. 491-494
(1992) Manual for the staging of cancer, , Kennedy BJ, ed, 4th ed. Philadelphia, PA: Lippincott
Lowe, V. J., Fletcher, J. W., Gobar, L., Prospective investigation of positron emission tomography in lung nodules (1998) J Clin Oncol, 16, pp. 1075-1084
Dewan, N. A., Gupta, N. C., Redepenning, L. S., Phalen, J. J., Frick, M. P., Diagnostic efficacy of FDG-PET imaging in solitary pulmonary nodules: Potential role in evaluation and management (1993) Chest, 104, pp. 997-1002
Avril, N., Ros, C. A., Schelling, M., Breast imaging with positron emission tomography and fluorine-18 fluorodeoxyglucose: Use and limitations (2000) J Clin Oncol, 18, pp. 3495-3502
Weinberg, I. N., Beylin, D., Zavarzin, V., Positron emission mammography: High-resolution biochemical breast imaging (2005) Technol Cancer Res Treat, 4, pp. 55-60
Buchanan, C. L., Morris, E. A., Dorn, P. L., Borgen, P. I., Van Zee, K. J., Utility of breast magnetic resonance imaging in patients with occult primary breast cancer (2005) Ann Surg Oncol, 12, pp. 1045-1053
Padhani, A. R., Dynamic contrast-enhanced MRI in clinical oncology: Current status and future directions (2002) J Magn Reson Imaging, 16, pp. 407-422
Goerres, G. V., Michel, S. C., Fehr, M. K., Follow-up of women with breast cancer: Comparison between MRI and FDG-PET (2003) Eur Radiol, 13, pp. 1635-1644
Heywang, S. H., Wolf, A., Pruss, E., Hilbertz, T. H., Eiermann, W., Permanetter, W., MR imaging of the breast with Gd-DTPA: Use and limitations (1989) Radiology, 171, pp. 95-103
Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions
OBJECTIVE: The purpose of our study was to compare dual-time-point (18)F-FDG PET/CT, performed with the patient in the prone position, and contrast-enhanced MRI in patients with suspected breast malignancy.; SUBJECTS AND METHODS: Forty-four patients with 55 breast lesions underwent two PET/CT scans (dual-time-point imaging) in the prone position and breast MRI. Sensitivity, specificity, and overall accuracy were calculated. In addition, the average percentage of change in standard uptake values (Delta%SUV(max)) between time point 1 and time point 2 was calculated for PET/CT. A final histopathologic diagnosis was available for all patients.; RESULTS: MRI showed an overall accuracy of 95%, with sensitivity and specificity of 98% and 80%. Conversely, dual-time-point PET/CT showed an accuracy of 84% for lesions with an SUV(max) > or = 2.5 or with a positive Delta%SUV(max), with sensitivity and specificity of 80% and 100% versus 69% accuracy, 62% sensitivity (both, p < 0.001), and 100% specificity (p not significant) for single-time-point PET/CT. On PET/CT, malignant lesions showed an increase in FDG between time points 1 and 2, with a Delta%SUV(max) of 11 +/- 24. Benign lesions showed either no change or a decrease in SUV(max) between time points 1 and 2, with a Delta%SUV(max) of -21 +/- 7.; CONCLUSION: A dual time point improves PET/CT accuracy in patients with a suspected breast malignancy over single-time-point PET/CT. On PET/CT, FDG is increasingly taken up over time in breast tumors; conversely, benign lesions show a decrease in FDG uptake over time. These changes in SUV might represent a reliable parameter that can be used to differentiate benign from malignant lesions of the breast on PET/CT examination.
Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions
No results.
Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions