Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions(449 views) Imbriaco M, Caprio MG, Limite G, Pace L, De Falco T, Capuano E, Salvatore M
Keywords: Breast Carcinoma, Fdg Pet, Pet Ct, Fluorodeoxyglucose F 18, Gadolinium, Gadolinium Pentetate, Adult, Article, Body Posture, Breast Tumor, Comparative Study, Computer Assisted Emission Tomography, Diagnostic Accuracy, Diagnostic Imaging, Histopathology, Human, Major Clinical Study, Mammography, Nuclear Magnetic Resonance Imaging, Priority Journal, Sensitivity And Specificity, Breast Neoplasms, Female, Magnetic Resonance Spectroscopy, Middle Aged, Positron-Emission Tomography, Radiopharmaceuticals, Reproducibility Of Results, X-Ray Computed,
Affiliations: *** IBB - CNR ***
Dipartimento di Scienze Biomorfologiche e Funzionali, Universita degli Studi di Napoli Federico II, Via Posillipo 196, 80123, Naples, Italy. mimbriaco@hotmail.com
National Research Council Napoli, Institute of Bio-structure and Bio-imaging, SDN Foundation, Naples, Italy
Dipartimento di Chirurgia, Università degli Studi di Napoli Federico II, Naples, Italy
References: Not available.
Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions
OBJECTIVE: The purpose of our study was to compare dual-time-point (18)F-FDG PET/CT, performed with the patient in the prone position, and contrast-enhanced MRI in patients with suspected breast malignancy.; SUBJECTS AND METHODS: Forty-four patients with 55 breast lesions underwent two PET/CT scans (dual-time-point imaging) in the prone position and breast MRI. Sensitivity, specificity, and overall accuracy were calculated. In addition, the average percentage of change in standard uptake values (Delta%SUV(max)) between time point 1 and time point 2 was calculated for PET/CT. A final histopathologic diagnosis was available for all patients.; RESULTS: MRI showed an overall accuracy of 95%, with sensitivity and specificity of 98% and 80%. Conversely, dual-time-point PET/CT showed an accuracy of 84% for lesions with an SUV(max) > or = 2.5 or with a positive Delta%SUV(max), with sensitivity and specificity of 80% and 100% versus 69% accuracy, 62% sensitivity (both, p < 0.001), and 100% specificity (p not significant) for single-time-point PET/CT. On PET/CT, malignant lesions showed an increase in FDG between time points 1 and 2, with a Delta%SUV(max) of 11 +/- 24. Benign lesions showed either no change or a decrease in SUV(max) between time points 1 and 2, with a Delta%SUV(max) of -21 +/- 7.; CONCLUSION: A dual time point improves PET/CT accuracy in patients with a suspected breast malignancy over single-time-point PET/CT. On PET/CT, FDG is increasingly taken up over time in breast tumors; conversely, benign lesions show a decrease in FDG uptake over time. These changes in SUV might represent a reliable parameter that can be used to differentiate benign from malignant lesions of the breast on PET/CT examination.
Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions
No results.
Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions