Role of cardiac MRI in evaluating patients with Anderson-Fabry disease: Assessing cardiac effects of long-term enzyme replacement therapy (335 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2012 Feb; 117(1): 19-28.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.461, 5-year impact factor: 1.44
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857659385&partnerID=40&md5=62d16e38ff417ed7d6980eee596c596a
Keywords: Anderson-Fabry Disease, Cardiac, Mri, T2 Relaxation Time, Agalsidase Beta, Alpha Galactosidase, Isoenzyme, Adult, Article, Enzyme Replacement, Female, Heart Disease, Human, Methodology, Nuclear Magnetic Resonance Imaging, Pathophysiology, Risk Factor, Vectorcardiography, Alpha-Galactosidase, Enzyme Replacement Therapy, Cine,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Biomorfologiche e Funzionali, Università Degli Studi 'Federico II', Via Posillipo 196, Napoli 80123, Italy
Dipartimento di Nefrologia, Università Degli Studi 'Federico II', Napoli, Italy
Dipartimento di Medicina Clinica e Scienze Cardiovascolari Ed Immunologiche, Università Degli Studi 'Federico II', Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
Azienda Ospedaliera-Universitaria di Parma, Parma, Italy
References:
Nagueh, S.F., Fabry disease (2003) Heart, 89 (8), pp. 819-82
Desnick, R.J., Brady, R., Barranger, J., Collins, A.J., Germain, D.P., Goldman, M., Grabowski, G., Wilcox, W.R., Fabry disease, an under-recognized multisystemic disorder: Expert recommendations for diagnosis, management, and enzyme replacement therapy (2003) Annals of Internal Medicine, 138 (4), pp. 338-346
Hopkin, R.J., Bissler, J., Banikazemi, M., Characterization of Fabry disease in 352 paediatric patients in the Fabry Registry (2008) Pediatr Res, 64, pp. 550-555. , 18596579 10.1203/PDR.0b013e318183f132
Linhart, A., Magage, S., Palecek, T., Bultas, J., Cardiac involvement in Fabry disease (2002) Acta Paediatrica, International Journal of Paediatrics, Supplement, 91 (439), pp. 15-20
Kampmann, C., Linhart, A., Baehner, F., Onset and progression of the Anderson-Fabry disease related cardiomyopathy (2008) Int J Cardiol, 130, pp. 367-373. , 18572264 10.1016/j.ijcard.2008.03.007
Eng, C.M., Guffon, N., Wilcox, W.R., Germain, D.P., Lee, P., Waldek, S., Caplan, L., Desnick, R.J., Safety and efficacy of recombinant human α-galactosidase a replacement therapy in Fabry's disease (2001) New England Journal of Medicine, 345 (1), pp. 9-16. , DOI 10.1056/NEJM200107053450102
Schiffmann, R., Kopp, J.B., Austin III, H.A., Sabnis, S., Moore, D.F., Weibel, T., Balow, J.E., Brady, R.O., Enzyme replacement therapy in fabry disease a randomized controlled trial (2001) Journal of the American Medical Association, 285 (21), pp. 2743-2749
Wilcox, W.R., Banikazemi, M., Guffon, N., Long-term safety and efficacy of enzyme replacement therapy for Fabry disease (2004) Am J Hum Genet, 75, pp. 65-74. , 15154115 10.1086/422366 1:CAS:528:DC%2BD2cXltFClsrc%3D
Weidemann, F., Breunig, F., Beer, M., Sandstede, J., Turschner, O., Voelker, W., Ertl, G., Strotmann, J.M., Improvement of cardiac function during enzyme replacement therapy in patients with fabry disease: A prospective strain rate imaging study (2003) Circulation, 108 (11), pp. 1299-1301. , DOI 10.1161/01.CIR.0000091253.71282.04
Moller, A.T., Jensen, T.S., Neurological manifestations in Fabry's disease (2007) Nature Clinical Practice Neurology, 3 (2), pp. 95-106. , DOI 10.1038/ncpneuro0407, PII NCPNEURO0407
Linhart, A., Elliott, P.M., The heart in Anderson-Fabry disease and other lysosomal storage disorders (2007) Heart, 93 (4), pp. 528-535. , DOI 10.1136/hrt.2005.063818
Branton, M., Schiffmann, R., Kopp, J.B., Natural history and treatment of renal involvement in Fabry disease (2002) J Am Soc Nephrol, 13, pp. 139-143
Zarate, Y.A., Hopkin, R.J., Fabry's disease (2008) Lancet, 372, pp. 1427-1435. , 18940466 10.1016/S0140-6736(08)61589-5 1:CAS:528:DC%2BD1cXht1KntLvL
Linhart, A., Treatment of Anderson-Fabry disease (2008) Heart, 94 (2), pp. 138-139. , DOI 10.1136/hrt.2006.113886
Von Scheidt, W., Eng, C.M., Fitzmaurice, T.F., An atypical variant of Fabry's disease with manifestations confined to the myocardium (1991) N Engl J Med, 324, pp. 395-399. , 10.1056/NEJM199102073240607
Germain, D.P., Waldek, S., Banikazemi, M., Bushinsky, D.A., Charrow, J., Desnick, R.J., Lee, P., Guffon, N., Sustained, long-term renal stabilization after 54 months of agalsidase β therapy in patients with fabry disease (2007) Journal of the American Society of Nephrology, 18 (5), pp. 1547-1557. , DOI 10.1681/ASN.2006080816
Breunig, F., Weidemann, F., Strotmann, J., Clinical benefit of enzyme replacement therapy in Fabry disease (2006) Kidney Int, 69, pp. 1216-1221. , 16609685 10.1038/sj.ki.5000208 1:CAS:528:DC%2BD28XivFOmsbY%3D
Beer, M., Weidemann, F., Breunig, F., Impact of enzyme replacement therapy on cardiac morphology and function and late enhancement in Fabry's cardiomiopathy (2006) Am J Cardiol, 97, pp. 1515-1518. , 16679096 10.1016/j.amjcard.2005.11.087 1:CAS:528:DC%2BD28XksVOntL0%3D
De Cobelli, F., Esposito, A., Belloni, E., Delayed-enhanced cardiac MRI for differentiation of Fabry's disease from symmetric hypertrophic cardiomiopathy (2009) AJR Am J Roentgenol, 192, pp. 97-W102. , 19234246 10.2214/AJR.08.1201
Higgins, C.B., Herfkens, R., Lipton, M.J., Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: Alterations in magnetic relaxation times (1983) American Journal of Cardiology, 52 (1), pp. 184-188
Imbriaco, M., Spinelli, L., Cuocolo, A., MRI characterization of myocardial tissue in patients with Fabry's disease (2007) AJR Am J Roentgenol, 188, pp. 850-853. , 17312078 10.2214/AJR.05.0442
Weidemann, F., Niemann, M., Breunig, F., Long-term effects of enzyme replacement therapy on Fabry cardiomyopathy: Evidence for a better outcome with early treatment (2009) Circulation, 119, pp. 524-529. , 19153271 10.1161/CIRCULATIONAHA.108.794529 1:CAS:528: DC%2BD1MXpt1ektw%3D%3D
Spinelli, L., Pisani, A., Sabbatini, M., Petretta, M., Andreucci, M.V., Procaccini, D., Lo Surdo, N., Cianciaruso, B., Enzyme replacement therapy with agalsidase β improves cardiac involvement in Fabry's disease (2004) Clinical Genetics, 66 (2), pp. 158-165. , DOI 10.1111/j.1399-0004.2004.00284.x
Imbriaco, M., Pisani, A., Spinelli, L., Effects of enzyme replacement therapy in patients with Anderson-Fabry disease: A prospective long-term magnetic resonance imaging study (2009) Heart, 95, pp. 1103-1107. , 19372091 10.1136/hrt.2008.162800 1:CAS:528:DC%2BD1MXovFSgtbY%3D
Kovacevic-Preradovic, T., Zuber, M., Attenhofer Jost, C.H., Anderson-Fabry disease: Long-term echocardiographic follow-up under enzyme replacement therapy (2008) Eur J Echocardiogr, 9, pp. 729-735. , 18490303 10.1093/ejechocard/jen129 1:STN:280:DC%2BD1cnot1Smtg%3D%3D
Nagueh, S. F., Fabry disease (2003) Heart, 89 (8), pp. 819-82
Desnick, R. J., Brady, R., Barranger, J., Collins, A. J., Germain, D. P., Goldman, M., Grabowski, G., Wilcox, W. R., Fabry disease, an under-recognized multisystemic disorder: Expert recommendations for diagnosis, management, and enzyme replacement therapy (2003) Annals of Internal Medicine, 138 (4), pp. 338-346
Hopkin, R. J., Bissler, J., Banikazemi, M., Characterization of Fabry disease in 352 paediatric patients in the Fabry Registry (2008) Pediatr Res, 64, pp. 550-555. , 18596579 10. 1203/PDR. 0b013e318183f132
Eng, C. M., Guffon, N., Wilcox, W. R., Germain, D. P., Lee, P., Waldek, S., Caplan, L., Desnick, R. J., Safety and efficacy of recombinant human -galactosidase a replacement therapy in Fabry's disease (2001) New England Journal of Medicine, 345 (1), pp. 9-16. , DOI 10. 1056/NEJM200107053450102
Wilcox, W. R., Banikazemi, M., Guffon, N., Long-term safety and efficacy of enzyme replacement therapy for Fabry disease (2004) Am J Hum Genet, 75, pp. 65-74. , 15154115 10. 1086/422366 1: CAS: 528: DC%2BD2cXltFClsrc%3D
Moller, A. T., Jensen, T. S., Neurological manifestations in Fabry's disease (2007) Nature Clinical Practice Neurology, 3 (2), pp. 95-106. , DOI 10. 1038/ncpneuro0407, PII NCPNEURO0407
Zarate, Y. A., Hopkin, R. J., Fabry's disease (2008) Lancet, 372, pp. 1427-1435. , 18940466 10. 1016/S0140-6736 (08) 61589-5 1: CAS: 528: DC%2BD1cXht1KntLvL
Germain, D. P., Waldek, S., Banikazemi, M., Bushinsky, D. A., Charrow, J., Desnick, R. J., Lee, P., Guffon, N., Sustained, long-term renal stabilization after 54 months of agalsidase therapy in patients with fabry disease (2007) Journal of the American Society of Nephrology, 18 (5), pp. 1547-1557. , DOI 10. 1681/ASN. 2006080816
Higgins, C. B., Herfkens, R., Lipton, M. J., Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: Alterations in magnetic relaxation times (1983) American Journal of Cardiology, 52 (1), pp. 184-188
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2012 Feb; 117(1): 19-28.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.461, 5-year impact factor: 1.44
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857659385&partnerID=40&md5=62d16e38ff417ed7d6980eee596c596a
Keywords: Anderson-Fabry Disease, Cardiac, Mri, T2 Relaxation Time, Agalsidase Beta, Alpha Galactosidase, Isoenzyme, Adult, Article, Enzyme Replacement, Female, Heart Disease, Human, Methodology, Nuclear Magnetic Resonance Imaging, Pathophysiology, Risk Factor, Vectorcardiography, Alpha-Galactosidase, Enzyme Replacement Therapy, Cine,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Biomorfologiche e Funzionali, Università Degli Studi 'Federico II', Via Posillipo 196, Napoli 80123, Italy
Dipartimento di Nefrologia, Università Degli Studi 'Federico II', Napoli, Italy
Dipartimento di Medicina Clinica e Scienze Cardiovascolari Ed Immunologiche, Università Degli Studi 'Federico II', Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
Azienda Ospedaliera-Universitaria di Parma, Parma, Italy
References:
Nagueh, S.F., Fabry disease (2003) Heart, 89 (8), pp. 819-82
Desnick, R.J., Brady, R., Barranger, J., Collins, A.J., Germain, D.P., Goldman, M., Grabowski, G., Wilcox, W.R., Fabry disease, an under-recognized multisystemic disorder: Expert recommendations for diagnosis, management, and enzyme replacement therapy (2003) Annals of Internal Medicine, 138 (4), pp. 338-346
Hopkin, R.J., Bissler, J., Banikazemi, M., Characterization of Fabry disease in 352 paediatric patients in the Fabry Registry (2008) Pediatr Res, 64, pp. 550-555. , 18596579 10.1203/PDR.0b013e318183f132
Linhart, A., Magage, S., Palecek, T., Bultas, J., Cardiac involvement in Fabry disease (2002) Acta Paediatrica, International Journal of Paediatrics, Supplement, 91 (439), pp. 15-20
Kampmann, C., Linhart, A., Baehner, F., Onset and progression of the Anderson-Fabry disease related cardiomyopathy (2008) Int J Cardiol, 130, pp. 367-373. , 18572264 10.1016/j.ijcard.2008.03.007
Eng, C.M., Guffon, N., Wilcox, W.R., Germain, D.P., Lee, P., Waldek, S., Caplan, L., Desnick, R.J., Safety and efficacy of recombinant human α-galactosidase a replacement therapy in Fabry's disease (2001) New England Journal of Medicine, 345 (1), pp. 9-16. , DOI 10.1056/NEJM200107053450102
Schiffmann, R., Kopp, J.B., Austin III, H.A., Sabnis, S., Moore, D.F., Weibel, T., Balow, J.E., Brady, R.O., Enzyme replacement therapy in fabry disease a randomized controlled trial (2001) Journal of the American Medical Association, 285 (21), pp. 2743-2749
Wilcox, W.R., Banikazemi, M., Guffon, N., Long-term safety and efficacy of enzyme replacement therapy for Fabry disease (2004) Am J Hum Genet, 75, pp. 65-74. , 15154115 10.1086/422366 1:CAS:528:DC%2BD2cXltFClsrc%3D
Weidemann, F., Breunig, F., Beer, M., Sandstede, J., Turschner, O., Voelker, W., Ertl, G., Strotmann, J.M., Improvement of cardiac function during enzyme replacement therapy in patients with fabry disease: A prospective strain rate imaging study (2003) Circulation, 108 (11), pp. 1299-1301. , DOI 10.1161/01.CIR.0000091253.71282.04
Moller, A.T., Jensen, T.S., Neurological manifestations in Fabry's disease (2007) Nature Clinical Practice Neurology, 3 (2), pp. 95-106. , DOI 10.1038/ncpneuro0407, PII NCPNEURO0407
Linhart, A., Elliott, P.M., The heart in Anderson-Fabry disease and other lysosomal storage disorders (2007) Heart, 93 (4), pp. 528-535. , DOI 10.1136/hrt.2005.063818
Branton, M., Schiffmann, R., Kopp, J.B., Natural history and treatment of renal involvement in Fabry disease (2002) J Am Soc Nephrol, 13, pp. 139-143
Zarate, Y.A., Hopkin, R.J., Fabry's disease (2008) Lancet, 372, pp. 1427-1435. , 18940466 10.1016/S0140-6736(08)61589-5 1:CAS:528:DC%2BD1cXht1KntLvL
Linhart, A., Treatment of Anderson-Fabry disease (2008) Heart, 94 (2), pp. 138-139. , DOI 10.1136/hrt.2006.113886
Von Scheidt, W., Eng, C.M., Fitzmaurice, T.F., An atypical variant of Fabry's disease with manifestations confined to the myocardium (1991) N Engl J Med, 324, pp. 395-399. , 10.1056/NEJM199102073240607
Germain, D.P., Waldek, S., Banikazemi, M., Bushinsky, D.A., Charrow, J., Desnick, R.J., Lee, P., Guffon, N., Sustained, long-term renal stabilization after 54 months of agalsidase β therapy in patients with fabry disease (2007) Journal of the American Society of Nephrology, 18 (5), pp. 1547-1557. , DOI 10.1681/ASN.2006080816
Breunig, F., Weidemann, F., Strotmann, J., Clinical benefit of enzyme replacement therapy in Fabry disease (2006) Kidney Int, 69, pp. 1216-1221. , 16609685 10.1038/sj.ki.5000208 1:CAS:528:DC%2BD28XivFOmsbY%3D
Beer, M., Weidemann, F., Breunig, F., Impact of enzyme replacement therapy on cardiac morphology and function and late enhancement in Fabry's cardiomiopathy (2006) Am J Cardiol, 97, pp. 1515-1518. , 16679096 10.1016/j.amjcard.2005.11.087 1:CAS:528:DC%2BD28XksVOntL0%3D
De Cobelli, F., Esposito, A., Belloni, E., Delayed-enhanced cardiac MRI for differentiation of Fabry's disease from symmetric hypertrophic cardiomiopathy (2009) AJR Am J Roentgenol, 192, pp. 97-W102. , 19234246 10.2214/AJR.08.1201
Higgins, C.B., Herfkens, R., Lipton, M.J., Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: Alterations in magnetic relaxation times (1983) American Journal of Cardiology, 52 (1), pp. 184-188
Imbriaco, M., Spinelli, L., Cuocolo, A., MRI characterization of myocardial tissue in patients with Fabry's disease (2007) AJR Am J Roentgenol, 188, pp. 850-853. , 17312078 10.2214/AJR.05.0442
Weidemann, F., Niemann, M., Breunig, F., Long-term effects of enzyme replacement therapy on Fabry cardiomyopathy: Evidence for a better outcome with early treatment (2009) Circulation, 119, pp. 524-529. , 19153271 10.1161/CIRCULATIONAHA.108.794529 1:CAS:528: DC%2BD1MXpt1ektw%3D%3D
Spinelli, L., Pisani, A., Sabbatini, M., Petretta, M., Andreucci, M.V., Procaccini, D., Lo Surdo, N., Cianciaruso, B., Enzyme replacement therapy with agalsidase β improves cardiac involvement in Fabry's disease (2004) Clinical Genetics, 66 (2), pp. 158-165. , DOI 10.1111/j.1399-0004.2004.00284.x
Imbriaco, M., Pisani, A., Spinelli, L., Effects of enzyme replacement therapy in patients with Anderson-Fabry disease: A prospective long-term magnetic resonance imaging study (2009) Heart, 95, pp. 1103-1107. , 19372091 10.1136/hrt.2008.162800 1:CAS:528:DC%2BD1MXovFSgtbY%3D
Kovacevic-Preradovic, T., Zuber, M., Attenhofer Jost, C.H., Anderson-Fabry disease: Long-term echocardiographic follow-up under enzyme replacement therapy (2008) Eur J Echocardiogr, 9, pp. 729-735. , 18490303 10.1093/ejechocard/jen129 1:STN:280:DC%2BD1cnot1Smtg%3D%3D
Nagueh, S. F., Fabry disease (2003) Heart, 89 (8), pp. 819-82
Desnick, R. J., Brady, R., Barranger, J., Collins, A. J., Germain, D. P., Goldman, M., Grabowski, G., Wilcox, W. R., Fabry disease, an under-recognized multisystemic disorder: Expert recommendations for diagnosis, management, and enzyme replacement therapy (2003) Annals of Internal Medicine, 138 (4), pp. 338-346
Hopkin, R. J., Bissler, J., Banikazemi, M., Characterization of Fabry disease in 352 paediatric patients in the Fabry Registry (2008) Pediatr Res, 64, pp. 550-555. , 18596579 10. 1203/PDR. 0b013e318183f132
Eng, C. M., Guffon, N., Wilcox, W. R., Germain, D. P., Lee, P., Waldek, S., Caplan, L., Desnick, R. J., Safety and efficacy of recombinant human -galactosidase a replacement therapy in Fabry's disease (2001) New England Journal of Medicine, 345 (1), pp. 9-16. , DOI 10. 1056/NEJM200107053450102
Wilcox, W. R., Banikazemi, M., Guffon, N., Long-term safety and efficacy of enzyme replacement therapy for Fabry disease (2004) Am J Hum Genet, 75, pp. 65-74. , 15154115 10. 1086/422366 1: CAS: 528: DC%2BD2cXltFClsrc%3D
Moller, A. T., Jensen, T. S., Neurological manifestations in Fabry's disease (2007) Nature Clinical Practice Neurology, 3 (2), pp. 95-106. , DOI 10. 1038/ncpneuro0407, PII NCPNEURO0407
Zarate, Y. A., Hopkin, R. J., Fabry's disease (2008) Lancet, 372, pp. 1427-1435. , 18940466 10. 1016/S0140-6736 (08) 61589-5 1: CAS: 528: DC%2BD1cXht1KntLvL
Germain, D. P., Waldek, S., Banikazemi, M., Bushinsky, D. A., Charrow, J., Desnick, R. J., Lee, P., Guffon, N., Sustained, long-term renal stabilization after 54 months of agalsidase therapy in patients with fabry disease (2007) Journal of the American Society of Nephrology, 18 (5), pp. 1547-1557. , DOI 10. 1681/ASN. 2006080816
Higgins, C. B., Herfkens, R., Lipton, M. J., Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: Alterations in magnetic relaxation times (1983) American Journal of Cardiology, 52 (1), pp. 184-188
Role of cardiac MRI in evaluating patients with Anderson-Fabry disease: Assessing cardiac effects of long-term enzyme replacement therapy
Purpose: Anderson-Fabry disease is a multisystemic disorder of lipid metabolism secondary to X-chromosome alterations and is frequently associated with cardiac manifestations such as left ventricular (LV) hypertrophy, gradually leading to an alteration in cardiac performance. The purpose of this study was to monitor, using magnetic resonance imaging (MRI), any changes produced by enzyme replacement therapy with agalsidase beta at the cardiac level in patients with Anderson-Fabry disease. Materials and methods: Sixteen (ten men, six women) patients with genetically confirmed Anderson-Fabry disease underwent cardiac MRI before starting enzyme replacement therapy (baseline study) and after 48 months of treatment with agalsidase beta at the dose of 1 mg/kg (follow-up study). Results: After 48 months of treatment, a significant reduction in LV mass and wall thickness was observed: 187±59 g vs. 149±44 g, and 16±3 mm vs. 13±3 mm, respectively. A significant reduction in T2 relaxation time was noted at the level of the interventricular septum (81±3 ms vs. 67±7 ms), at the apical level (80±8 ms vs. 63±6 ms) and at the level of the lateral wall (82±8 ms vs. 63±10 ms) (p0.05) (mean bias 1.0); however, an improvement was noted in the New York Heart Association (NYHA) class of the majority of patients (12/16) (p
Purpose: Anderson-Fabry disease is a multisystemic disorder of lipid metabolism secondary to X-chromosome alterations and is frequently associated with cardiac manifestations such as left ventricular (LV) hypertrophy, gradually leading to an alteration in cardiac performance. The purpose of this study was to monitor, using magnetic resonance imaging (MRI), any changes produced by enzyme replacement therapy with agalsidase beta at the cardiac level in patients with Anderson-Fabry disease. Materials and methods: Sixteen (ten men, six women) patients with genetically confirmed Anderson-Fabry disease underwent cardiac MRI before starting enzyme replacement therapy (baseline study) and after 48 months of treatment with agalsidase beta at the dose of 1 mg/kg (follow-up study). Results: After 48 months of treatment, a significant reduction in LV mass and wall thickness was observed: 187±59 g vs. 149±44 g, and 16±3 mm vs. 13±3 mm, respectively. A significant reduction in T2 relaxation time was noted at the level of the interventricular septum (81±3 ms vs. 67±7 ms), at the apical level (80±8 ms vs. 63±6 ms) and at the level of the lateral wall (82±8 ms vs. 63±10 ms) (p0.05) (mean bias 1.0); however, an improvement was noted in the New York Heart Association (NYHA) class of the majority of patients (12/16) (p
Role of cardiac MRI in evaluating patients with Anderson-Fabry disease: Assessing cardiac effects of long-term enzyme replacement therapy
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Role of cardiac MRI in evaluating patients with Anderson-Fabry disease: Assessing cardiac effects of long-term enzyme replacement therapy
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Imbriaco M, Pisani A, Spinelli L, Cuocolo A, Messalli G, Capuano E, Marmo M, Liuzzi R, Visciano B, Cianciaruso B, Salvatore M
* Effects of enzyme-replacement therapy in patients with Anderson-Fabry disease: a prospective long-term cardiac magnetic resonance imaging study (542 views)
Heart (ISSN: 1355-6037, 1468-201x), 2009 Jul; 95(13): 1103-1107.
Impact Factor: 5.385
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Imbriaco M, Spinelli L, Cuocolo A, Maurea S, Sica G, Quarantelli M, Pisani A, Liuzzi R, Cianciaruso B, Sabbatini M, Salvatore M
* MRI characterization of myocardial tissue in patients with Fabry's disease (594 views)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2007 Mar; 188(3): 850-853.
Impact Factor: 2.47
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* Cardiac sympathetic neuronal damage precedes myocardial fibrosis in patients with Anderson-Fabry disease (238 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2017 Jul 22; N/D: N/D-N/D.
Impact Factor: 7.704
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Spinelli L, Pellegrino T, Pisani A, Giudice CA, Riccio E, Imbriaco M, Salvatore M, Trimarco B, Cuocolo A
* Relationship between left ventricular diastolic function and myocardial sympathetic denervation measured by (123)I-meta-iodobenzylguanidine imaging in Anderson-Fabry disease (264 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2016 Apr; 43(4): 729-739.
Impact Factor: 7.277
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Nappi C, Altiero M, Imbriaco M, Nicolai E, Giudice CA, Aiello M, Diomiaiuti CT, Pisani A, Spinelli L, Cuocolo A
* First experience of simultaneous PET/MRI for the early detection of cardiac involvement in patients with Anderson-Fabry disease (534 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42(7): 1025-1031.
Impact Factor: 5.537
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Parenti G, Fecarotta S, la Marca G, Rossi B, Ascione S, Donati MA, Morandi LO, Ravaglia S, Pichiecchio A, Ombrone D, Sacchini M, Pasanisi MB, De Filippi P, Danesino C, Della Casa R, Romano A, Mollica C, Rosa M, Agovino T, Nusco E, Porto C, Andria G
* A Chaperone Enhances Blood Alpha-Glucosidase Activity In Pompe Disease Patients Treated With Enzyme Replacement Therapy (235 views)
Molecular Therapy, 2014 Nov; 22(11): 2004-2012.
Impact Factor: 6.425
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Andreotti G, Citro V, Correra A, Cubellis MV
* A thermodynamic assay to test pharmacological chaperones for Fabry disease (396 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1840(3): 1214-1224.
Impact Factor: 4.882
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Cammisa M, Correra A, Andreotti G, Cubellis MV
* Fabry_CEP: a tool to identify Fabry mutations responsive to pharmacological chaperones (415 views)
Orphanet Journal Of Rare Diseases (ISSN: 1750-1172), 2013 Jul 24; 8: 111-111.
Impact Factor: 3.958
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Palma G, Greco D, Innocenti S, Alfano B
* Method Of Generating 2d Or 3d Maps Of Mri T1 And T2 Relaxation Times (309 views) (PDF 198 views)
Patentsofficial Gazette Of The United States Patent And Trademark Office, 2012 Sep 05; 20120223710: 18-18.
Impact Factor: 0
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Andreotti G, Citro V, De Crescenzo A, Orlando P, Cammisa M, Correra A, Cubellis MV
* Therapy of Fabry disease with pharmacological chaperones: from in silico predictions to in vitro tests (1698 views)
Orphanet Journal Of Rare Diseases (ISSN: 1750-1172), 2011 Oct 17; 6: 66-66.
Impact Factor: 5.074
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Andreotti G, Guarracino MR, Cammisa M, Correra A, Cubellis MV
* Prediction of the responsiveness to pharmacological chaperones: lysosomal human alpha-galactosidase, a case of study (493 views)
Orphanet Journal Of Rare Diseases (ISSN: 1750-1172), 2010 Dec 8; 5: 36-36.
Impact Factor: 5.933
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Imbriaco M, Messalli G, Avitabile G, Cuocolo A, Maurea S, Soscia F, Pisani A
* Cardiac magnetic resonance imaging illustrating Anderson-Fabry disease progression (283 views)
Br J Radiol (ISSN: 0007-1285, 1748-880xelectronic, 0007-1285linking), 2010 Dec; 83(996): e249-e249.
Impact Factor: 2.062
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Imbriaco M, Pisani A, Spinelli L, Cuocolo A, Messalli G, Capuano E, Marmo M, Liuzzi R, Visciano B, Cianciaruso B, Salvatore M
* Effects of enzyme-replacement therapy in patients with Anderson-Fabry disease: a prospective long-term cardiac magnetic resonance imaging study (542 views)
Heart (ISSN: 1355-6037, 1468-201x), 2009 Jul; 95(13): 1103-1107.
Impact Factor: 5.385
View Export to BibTeX Export to EndNote
Imbriaco M, Spinelli L, Cuocolo A, Maurea S, Sica G, Quarantelli M, Pisani A, Liuzzi R, Cianciaruso B, Sabbatini M, Salvatore M
* MRI characterization of myocardial tissue in patients with Fabry's disease (594 views)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2007 Mar; 188(3): 850-853.
Impact Factor: 2.47
View Export to BibTeX Export to EndNote
12 Records (7 excluding Abstracts).
Total impact factor: 56.707 (39.68 excluding Abstracts).
Total 5 year impact factor: 56.464 (36.801 excluding Abstracts).
Total impact factor: 56.707 (39.68 excluding Abstracts).
Total 5 year impact factor: 56.464 (36.801 excluding Abstracts).
335 views. Last view on Wednesday 12 April 2023, 23:10:15
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