Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (506 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.831, 5-year impact factor: 5.623
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84870031931&partnerID=40&md5=88ae3add55739ad4a09c2f03b4a9aba9
Keywords: Antiproliferation, Biological Activity, Copper, Peptides, Uv Vis Spectroscopy, After-Treatment, Alzheimer, S Disease, Amino Group, Amino-Terminal Domain, Aspartate Residue, Brain-Derived Neurotrophic Factors, Carboxylate Groups, Metal Addition, Metal Binding, Metal Coordination, N-Terminal Domains, Nerve Growth Factor, Neuroblastoma Cell Lines, Neurodegenerative Disorders, Nitrogen Atom, Parallel Tempering, Pathological Conditions, Peptide Fragments, Peripheral Nervous System, Physiological Ph, Potentiometry, Proliferative Activity, Protein Domains, Recognition Site, Spectroscopic Method, Synaptic Plasticity, Terminal Amino Groups, Amides, Amino Acids, Bioactivity, Carboxylation, Cell Culture, Coordination Reactions, Digital Storage, Enzyme Inhibition, Metal Ions, Ph Effects, Spectroscopic Analysis, Ultraviolet Visible Spectroscopy, Copper Compounds, Brain Derived Neurotrophic Factor, Amino Acid Sequence, Article, Binding Site, Chemistry, Circular Dichroism, Human, Metabolism, Ultraviolet Spectrophotometry, Brain-Derived Neurotrophic Factor Metabolism, Copper Chemistry Metabolism, Nerve Growth Factor Chemistry Metabolism, Peptide Fragments Chemistry Metabolism,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Italy.
Scuola Superiore di Catania, Via Vadisavoia 9, 95123 Catania, Italy
Istituto di Biostrutture e Bioimmagini-CNR, Dipartimento di Scienze Chimiche, Viale A. Doria 6, 95125 Catania, Italy
References:
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Adlard, P. A., Parncutt, J. M., Finkelstein, D. I., Bush, A. I., (2010) J. Neurosci., 30, pp. 1631-1636
(2011) Neurodegeneration: Metallostasis and Proteostasis, , (Eds.: D. Milardi, E. Rizzarelli), Royal Society of Chemistry, Cambridge, UK
Adlard, P. A., Bica, L., White, A. R., Nurjono, M., Filiz, G., Crouch, P. J., Donnelly, P. S., Bush, A. I., (2011) PLoS ONE, 6, p. 17669. , e
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Robinson, R. C., Radziejewski, C., Stuart, D. I., Jones, E. Y., (1995) Biochemistry, 34, pp. 4139-4146
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Daniele, P. G., Prenesti, E., Ostacoli, G., (1996) J. Chem. Soc. Dalton Trans., pp. 3269-3275
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S v g, I., Osz, K., (2006) Dalton Trans., pp. 3841-3854
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uczkowski, M., Kozlowski, H., Stawikowski, M., Rolka, K., Gaggelli, E., Valensin, D., Valensin, G., (2002) J. Chem. Soc. Dalton Trans., pp. 2269-2274
Magr, A., D'Alesssandro, F., Distefano, D. A., Campagna, T., Pappalardo, G., Impellizzeri, G., La Mendola, D., (2012) J. Inorg. Biochem., 113, pp. 15-24
Vagliasindi, L. I., Arena, G., Bonomo, R. P., Pappalardo, G., Tabb, G., (2011) Dalton Trans., 40, pp. 2441-2450
De Vries, S. J., Van Dijk, M., Bonvin, A. M., (2010) Nat. Protoc., 5, pp. 883-897
Bonomo, R. P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., MacCarrone, G., Nicoletti, F., Vecchio, G., (2003) Dalton Trans., pp. 4406-4415
Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W., Klein, M. L., (1983) J. Chem. Phys., 79, pp. 926-935
Sch fer, A., Huber, C., Ahlrichs, R., (1994) J. Chem. Phys., 100, pp. 5829-5835
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.831, 5-year impact factor: 5.623
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84870031931&partnerID=40&md5=88ae3add55739ad4a09c2f03b4a9aba9
Keywords: Antiproliferation, Biological Activity, Copper, Peptides, Uv Vis Spectroscopy, After-Treatment, Alzheimer, S Disease, Amino Group, Amino-Terminal Domain, Aspartate Residue, Brain-Derived Neurotrophic Factors, Carboxylate Groups, Metal Addition, Metal Binding, Metal Coordination, N-Terminal Domains, Nerve Growth Factor, Neuroblastoma Cell Lines, Neurodegenerative Disorders, Nitrogen Atom, Parallel Tempering, Pathological Conditions, Peptide Fragments, Peripheral Nervous System, Physiological Ph, Potentiometry, Proliferative Activity, Protein Domains, Recognition Site, Spectroscopic Method, Synaptic Plasticity, Terminal Amino Groups, Amides, Amino Acids, Bioactivity, Carboxylation, Cell Culture, Coordination Reactions, Digital Storage, Enzyme Inhibition, Metal Ions, Ph Effects, Spectroscopic Analysis, Ultraviolet Visible Spectroscopy, Copper Compounds, Brain Derived Neurotrophic Factor, Amino Acid Sequence, Article, Binding Site, Chemistry, Circular Dichroism, Human, Metabolism, Ultraviolet Spectrophotometry, Brain-Derived Neurotrophic Factor Metabolism, Copper Chemistry Metabolism, Nerve Growth Factor Chemistry Metabolism, Peptide Fragments Chemistry Metabolism,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Italy.
Scuola Superiore di Catania, Via Vadisavoia 9, 95123 Catania, Italy
Istituto di Biostrutture e Bioimmagini-CNR, Dipartimento di Scienze Chimiche, Viale A. Doria 6, 95125 Catania, Italy
References:
Levi-Montalcini, R., Hamburger, V., (1951) J. Exp. Zool., 116, pp. 321-36
Johnson Jr., E.M., Tuszynski, M.H., (2008) CNS Regeneration, pp. 95-144. , in (Eds.: J. H. Kordower, M. H. Tuszynski), Academic Press, San Diego,
Barde, Y.A., Edgar, D., Thoenen, H., (1982) EMBO J., 1, pp. 549-553
Mowla, S.J., Farhadi, H.F., Pareek, S., Atwal, J.K., Morris, S.J., Seidah, N.G., Murphy, R.A., (2001) J. Biol. Chem., 276, pp. 12660-12666
Mowla, S.J., Pareek, S., Farhadi, H.F., Petrecca, K., Fawcett, J.P., Seidah, N.B., Morris, S.J., Murphy, R.A., (1999) J. Neurosci., 19, pp. 2069-2080
Lee, R., Kermani, P., Teng, K.K., Hempstead, B.L., (2001) Science, 294, pp. 1945-1948
Nikoletopoulou, V., Lickert, H., Frade, J.M., Rencurel, C., Giallonardo, P., Zhang, L., Bibel, M., Barde, Y.A., (2010) Nature, 467, pp. 59-63
Rauskolb, S., Zagrebelsky, M., Dreznjak, A., Deogracias, R., Matsumoto, T., Wiese, S., Erne, B., Barde, Y.A., (2010) J. Neurosci., 30, pp. 1739-1749
Matsumoto, T., Rauskolb, S., Polack, M., Klose, J., Kolbeck, R., Korte, M., Barde, Y.A., (2008) Nat. Neurosci., 11, pp. 131-133
Soppet, D., Escandon, E., Maragos, J., Middlemas, D.S., Reid, S.W., Blair, J., Burton, L.E., Parada, L.F., (1991) Cell, 65, pp. 895-903
Carter, B.D., Kaltschmidt, C., Kaltschmidt, B., Offenhäuser, N., Böhm-Matthaei, R., Baeuerle, P.A., Barde, Y.A., (1996) Science, 272, pp. 542-545
Tanaka, J., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G.C., Kasai, H., (2008) Science, 319, pp. 1683-1687
(2009) Erratum in Science, 326, p. 1482
Horch, H.W., Katz, L.C., (2002) Nat. Neurosci., 5, pp. 1177-1184
Figurov, A., Pozzo-Miller, L.D., Olafsson, P., Wang, T., Lu, B., (1996) Nature, 381, pp. 706-709
Kang, H., Schuman, E.M., (1995) Science, 267, pp. 1658-1662
Yamada, K., Mizuno, M., Nabeshima, T., (2002) Life Sci., 70, pp. 735-744
Egan, M.F., Kojima, M., Callicot, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., Zaitsev, E., Weinberger, D.R., (2003) Cell, 112, pp. 257-269
Cathomas, F., Vogler, C., Euler-Sigmund, J.C., De Quervain, D.J., Papassotiropoulos, A., (2010) Int. J. Neuropsychopharmacol., 13, pp. 975-980
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Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences development, maintenance, survival, and synaptic plasticity of central and peripheral nervous systems. Altered BDNF signaling is involved in several neurodegenerative disorders including Alzheimer's disease. Metal ions may influence the BDNF activity and it is well known that the alteration of Cu(2+) homeostasis is a prominent factor in the development of neurological pathologies. The N-terminal domain of BDNF represents the recognition site of its specific receptor TrkB, and metal ions interaction with this protein domain may influence the protein/receptor interaction. In spite of this, no data inherent the interaction of BDNF with Cu(2+) ions has been reported up to now. Cu(2+) complexes of the peptide fragment BDNF(1-12) encompassing the sequence 1-12 of N-terminal domain of human BDNF protein were characterized by means of potentiometry, spectroscopic methods (UV/Vis, CD, EPR), parallel tempering simulations and DFT-geometry optimizations. Coordination features of the acetylated form, Ac-BDNF(1-12), were also characterized to understand the involvement of the terminal amino group. Whereas, an analogous peptide, BDNF(1-12)D3N, in which the aspartate residue was substituted by an asparagine, was synthesized to provide evidence on the possible role of carboxylate group in Cu(2+) coordination. The results demonstrated that the amino group is involved in metal binding and the metal coordination environment of the predominant complex species at physiological pH consisted of one amino group, two amide nitrogen atoms, and one carboxylate group. Noteworthy, a strong decrease of the proliferative activity of both BDNF(1-12) and the whole protein on a SHSY5Y neuroblastoma cell line was found after treatment in the presence of Cu(2+). The effect of metal addition is opposite to that observed for the analogous fragment of nerve growth factor (NGF) protein, highlighting the role of specific domains, and suggesting that Cu(2+) may drive different pathways for the BDNF and NGF in physiological as well as pathological conditions. Copyright 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences development, maintenance, survival, and synaptic plasticity of central and peripheral nervous systems. Altered BDNF signaling is involved in several neurodegenerative disorders including Alzheimer's disease. Metal ions may influence the BDNF activity and it is well known that the alteration of Cu(2+) homeostasis is a prominent factor in the development of neurological pathologies. The N-terminal domain of BDNF represents the recognition site of its specific receptor TrkB, and metal ions interaction with this protein domain may influence the protein/receptor interaction. In spite of this, no data inherent the interaction of BDNF with Cu(2+) ions has been reported up to now. Cu(2+) complexes of the peptide fragment BDNF(1-12) encompassing the sequence 1-12 of N-terminal domain of human BDNF protein were characterized by means of potentiometry, spectroscopic methods (UV/Vis, CD, EPR), parallel tempering simulations and DFT-geometry optimizations. Coordination features of the acetylated form, Ac-BDNF(1-12), were also characterized to understand the involvement of the terminal amino group. Whereas, an analogous peptide, BDNF(1-12)D3N, in which the aspartate residue was substituted by an asparagine, was synthesized to provide evidence on the possible role of carboxylate group in Cu(2+) coordination. The results demonstrated that the amino group is involved in metal binding and the metal coordination environment of the predominant complex species at physiological pH consisted of one amino group, two amide nitrogen atoms, and one carboxylate group. Noteworthy, a strong decrease of the proliferative activity of both BDNF(1-12) and the whole protein on a SHSY5Y neuroblastoma cell line was found after treatment in the presence of Cu(2+). The effect of metal addition is opposite to that observed for the analogous fragment of nerve growth factor (NGF) protein, highlighting the role of specific domains, and suggesting that Cu(2+) may drive different pathways for the BDNF and NGF in physiological as well as pathological conditions. Copyright 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives
Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (360 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
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Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (435 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
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Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (498 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
Impact Factor: 5.925
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Pizzo E, Merlino A, Turano M, Russo Krauss I, Coscia F, Zanfardino A, Varcamonti M, Furia A, Giancola C, Mazzarella L, Sica F, D'Alessio G
* A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish (804 views)
Biochem J (ISSN: 1470-8728electronic, 0264-6021linking, 0264-6021print), 2011 Jan 15; 433(2): 345-355.
Impact Factor: 4.897
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (443 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (522 views)
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
Impact Factor: 3.825
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Arpaia P, Clemente F, Manna C
* In vivo assessment of skin impedance recovery after low-voltage pulses electroporation (5544 views)
Imeko Tc Int Symp (ISSN: 9788-8903), 2008; N/D: 934-937.
Impact Factor: 0
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Improta R, Barone V, Santoro F
* Ab initio calculations of absorption spectra of large molecules in solution: Coumarin C153 (343 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(3): 405-408.
Impact Factor: 10.031
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Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (474 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
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Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
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Caliendo G, Fiorino F, Grieco P, Perissutti E, De Luca S, Giuliano A, Santelli G, Califano D, Severino B, Santagada V
Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids (533 views)
Farmaco (ISSN: 0014-827x), 1999 Nov; 54(11-12): 785-790.
Impact Factor: 0.406
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* The ability of the NiSOD binding loop to chelate zinc(ii): the role of the terminal amino group in the enzymatic functions (125 views)
Dalton T (ISSN: 1477-9226linking, 1477-9234), 2019 Apr 15; N/D: N/D-N/D.
Impact Factor: 3.647
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (197 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (473 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
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Magrì A, Tabbì G, Giuffrida A, Pappalardo G, Satriano C, Naletova I, Nicoletti VG, Attanasio F
* Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties (233 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016 Aug 27; 164: 59-69.
Impact Factor: 3.348
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La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
* Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity (392 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2016 Jan 20; 8(1): 118-124.
Impact Factor: 3.975
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Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (363 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
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Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (727 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
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Picano E, Vañó E, Rehani MM, Cuocolo A, Mont L, Bodi V, Bar O, Maccia C, Pierard L, Sicari R, Plein S, Mahrholdt H, Lancellotti P, Knuuti J, Heidbuchel H, Di Mario C, Badano LP
* The appropriate and justified use of medical radiation in cardiovascular imaging: a position document of the ESC Associations of Cardiovascular Imaging, Percutaneous Cardiovascular Interventions and Electrophysiology (752 views)
Eur Heart J (ISSN: 0195-668x), 2014 Mar; 35(10): 665-672.
Impact Factor: 15.203
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (508 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
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Cigliano L, De Rosa L, Diana D, Di Stasi R, Spagnuolo MS, Maresca B, Fattorusso R, D'Andrea LD
* Structure and biological activity of a conformational constrained apolipoprotein A-I-derived helical peptide targeting the protein haptoglobin (401 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(93): 51353-51361.
Impact Factor: 3.84
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Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (440 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
Impact Factor: 3.274
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Di Natale G, Osz K, Kállay C, Pappalardo G, Sanna D, Impellizzeri G, Sóvágó I, Rizzarelli E
* Affinity, speciation, and molecular features of copper(II) complexes with a prion tetraoctarepeat domain in aqueous solution: insights into old and new results (422 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2013 Mar 11; 19(11): 3751-3761.
Impact Factor: 5.696
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Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (589 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
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Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, Nevolo MT, Fedele M, Greco A, Greco M, Brunetti G, Fusco A, Foti D, Brunetti A
* The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake (690 views)
Molecular Endocrinology (ISSN: 0888-8809, 1944-9917electronic), 2012 Sep; 26(9): 1578-1589.
Impact Factor: 4.746
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Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
* Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma (490 views) (PDF 236 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2012 Apr 1; 82(5): 1802-1808.
Impact Factor: 4.524
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Pilla P, Sandomenico A, Malachovsk V, Borriello A, Giordano M, Cutolo A, Ruvo M, Cusano A
* A protein-based biointerfacing route toward label-free immunoassays with long period gratings in transition mode (398 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic, 0956-5663linking), 2012 Jan 15; 31(1): 486-491.
Impact Factor: 5.437
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
View Export to BibTeX Export to EndNote
Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (360 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
View Export to BibTeX Export to EndNote
Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
* Molecular organization of the cullin E3 ligase adaptor KCTD11 (435 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
View Export to BibTeX Export to EndNote
Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (498 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Pizzo E, Merlino A, Turano M, Russo Krauss I, Coscia F, Zanfardino A, Varcamonti M, Furia A, Giancola C, Mazzarella L, Sica F, D'Alessio G
* A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish (804 views)
Biochem J (ISSN: 1470-8728electronic, 0264-6021linking, 0264-6021print), 2011 Jan 15; 433(2): 345-355.
Impact Factor: 4.897
View Export to BibTeX Export to EndNote
Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
View Export to BibTeX Export to EndNote
Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (443 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (522 views)
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
Impact Factor: 3.825
View Export to BibTeX Export to EndNote
Arpaia P, Clemente F, Manna C
* In vivo assessment of skin impedance recovery after low-voltage pulses electroporation (5544 views)
Imeko Tc Int Symp (ISSN: 9788-8903), 2008; N/D: 934-937.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Improta R, Barone V, Santoro F
* Ab initio calculations of absorption spectra of large molecules in solution: Coumarin C153 (343 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(3): 405-408.
Impact Factor: 10.031
View Export to BibTeX Export to EndNote
Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (474 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
View Export to BibTeX Export to EndNote
Saviano M, Romanelli A, Bucci E, Pedone C, Mischiati C, Bianchi N, Feriotto G, Borgatti M, Gambari R
Computational procedures to explain the different biological activity of DNA/DNA, DNA/PNA and PNA/PNA hybrid molecules mimicking NF-κB binding sites (493 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2000 Dec; 18(3): 353-362.
Impact Factor: 1.826
View Export to BibTeX Export to EndNote
Caliendo G, Fiorino F, Grieco P, Perissutti E, De Luca S, Giuliano A, Santelli G, Califano D, Severino B, Santagada V
Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids (533 views)
Farmaco (ISSN: 0014-827x), 1999 Nov; 54(11-12): 785-790.
Impact Factor: 0.406
View Export to BibTeX Export to EndNote
29 Records (29 excluding Abstracts).
Total impact factor: 117.217 (117.217 excluding Abstracts).
Total 5 year impact factor: 116.602 (116.602 excluding Abstracts).
Total impact factor: 117.217 (117.217 excluding Abstracts).
Total 5 year impact factor: 116.602 (116.602 excluding Abstracts).
506 views. Last view on Monday 27 February 2023, 12:30:29
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