Identification of viable myocardium in patients with chronic coronary artery disease using rest-redistribution thallium-201 tomography: Optimal image analysis (435 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Nov; 39(11): 1869-1874.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.064, 5-year impact factor: 5.331
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031742139&partnerID=40&md5=430c757df72ee8d3be6fd24d5ed7408b
Keywords: Myocardial Viability, Thallium-201, Thresholds, Thallium 201, Adult, Aged, Article, Cell Viability, Clinical Article, Controlled Study, Coronary Artery Disease, Diagnostic Accuracy, Echocardiography, Female, Heart Ejection Fraction, Heart Muscle, Heart Muscle Revascularization, Human, Image Analysis, Priority Journal, Prognosis, Single Photon Emission Computer Tomography, Statistical Analysis, Validation Process, Case-Control Studies, Coronary Disease, Image Processing, Computer-Assisted, Middle Aged, Myocardial Revascularization, Roc Curve, Sensitivity And Specificity, Thallium Radioisotopes, Emission-Computed, Single-Photon,
Affiliations:
trav.priv. Sanseverino 5/A, 80128, Napoli, Italy
trav. priv. Sanseverino 5/A, 80128, Napoli, Italy
References:
Gibson, R.S., Watson, D.D., Taylor, G.J., Prospective assessment of regional myocardial perfusion before and after coronary revascularization surgery by quantitative thallium-201 scintigraphy (1983) J Am Coll Cardiol, 1, pp. 804-81
Melin, J.A., Wijns, W., Keyeux, A., Assessment of thallium-201 redistribution versus glucose uptake as a predictor of viability after coronary occlusion and reperfusion (1988) Circulation, 77, pp. 927-934
Yamamoto, K., Asada, S., Masuyama, T., Myocardial hibernation in the infarcted region cannot be assessed from the presence of stress-induced ischemia: Usefulness of delayed image of exercise thallium-201 (1993) Am Heart J, 125, pp. 33-40
Sabia, P.J., Powers, E.R., Ragosta, M., Smith, W.H., Watson, D.D., Kaul, S., Role of quantitative planar thallium-201 imaging for determining viability in patients with acute myocardial infarction and a totally occluded infarct-related artery (1993) J Nucl Med, 34, pp. 728-736
Liu, P., Kiess, M.C., Okada, R.D., The persistent defect on exercise thallium imaging and its fate after myocardial revascularization: Does it represent scar or ischemia (1985) Am Heart J, 110, pp. 996-1001
Kiat, H., Berman, D.S., Maddahy, J., Late reversibility of tomographic myocardial thallium-201 defects: An accurate marker of myocardial viability (1988) J Am Coll Cardiol, 12, pp. 1456-1463
Dilsizian, V., Rocco, T.P., Freeman, N.M., Leon, M.B., Bonow, R.O., Enhanced detection of ischemic but viable myocardium by the reinjection of thallium after stress-redistribution imaging (1990) N Engl J Med, 323, pp. 141-146
Ohtani, H., Tamaki, N., Yonekura, Y., Value of thallium-201 reinjection after delayed SPECT imaging for predicting reversible ischemia after coronary artery bypass grafting (1990) Am J Cardiol, 66, pp. 394-399
Ragosta, M., Beller, G.A., Watson, D.D., Kaul, S., Gimple, L.W., Quantitative planar rest-redistribution thallium-201 imaging in detection of myocardial viability and prediction of improvement in left ventricular function after coronary bypass surgery in patients with severely depressed left ventricular function (1993) Circulation, 87, pp. 1630-1641
Bax, J.J., Cornel, J.H., Visser, F.C., Prediction of recovery of myocardial dysfunction after revascularization. Comparison of fluorine-18 fluorodeoxyglucose/thallium-201 SPECT, thallium-201 stress-reinjection SPECT and dobutamine echocardiography (1996) J Am Coll Cardiol, 28, pp. 558-564
Arnese, M., Cornel, J.H., Salustri, A., Prediction of improvement of regional left ventricular function after surgical revascularization. A comparison of low-dose dobutamine echocardiography with single-photon emission computed tomography (1995) Circulation, 91, pp. 2748-2752
Haque, T., Furukawa, T., Takahashi, M., Kinoshita, M., Identification of hibernating myocardium by dobutamine stress echocardiography: Comparison with thallium-201 reinjection imaging (1995) Am Heart J, 130, pp. 553-563
Vanoverschelde, J.L.J., D'Hondt, A.M., Marwivk, T., Head-to head comparison of exercise-redistribution-reinjection thallium single-photon emission computed tomograhy and low dose dobutamine echocardiography for prediction of reversibility of chronic left ventricular ischemic dysfunction (1996) J Am Coll Cardiol, 28, pp. 432-442
Matsunari, I., Fujino, S., Taki, J., Quantitative rest technetium-99m tetrofosmin imaging in predicting functional recovery after revascularization: Comparison with rest-redistribution thallium-201 (1997) J Am Coll Cardiol, 29, pp. 1226-1233
Perrone-Filardi, P., Pace, L., Prastaro, M., Dobutamine echocardiography predicts improvement of hypoperfused dysfunctional myocardium after revascularization in patients with coronary artery disease (1995) Circulation, 91, pp. 2556-2565
Schiller, N.B., Shaha, P.M., Crawford, M., Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echocardiogr, 2, pp. 358-367
Berger, B.C., Watson, D.D., Burwell, L.R., Redistribution of thallium at rest with stable and unstable angina and the effect of coronary artery bypass surgery (1979) Circulation, 60, pp. 1114-1125
Iskandrian, A.S., Hakki, A., Kane, S.A., Rest and redistribution thallium-201 myocardial scintigraphy to predict improvement in left ventricular function after coronary arterial bypass grafting (1983) Am J Cardiol, 51, pp. 1312-1316
Udelson, J.E., Coleman, P.S., Metherall, J., Predicting recovery of severe regional dysfunction. Comparison of resting scintigraphy with thallium-201 and technetium-99m-sestamibi (1994) Circulation, 89, pp. 2552-2561
Qureshi, U., Nagueh, S.F., Afridi, I., Dobutamine echocardiography and quantitative rest-redistribution 201Tl tomography in myocardial hibernation. Relation of contractile reserve to 201Tl uptake and comparative prediction of recovery of function (1997) Circulation, 95, pp. 626-635
Matinho, N.V.S., Keogh, B.E., Costa, D.C., Lammerstma, A.A., Ell, P.J., Camici, P.G., Pathophysiology of chronic left ventricular dysfunction. New insight from the measurement of absolute myocardial blood flow and glucose utilization (1996) Circulation, 93, pp. 737-744
Coversano, A., Walsh, J.F., Geltman, E.M., Perez, J.E., Bergmann, S.R., Gropler, R.J., Delineation of myocardial stunning and hibernation by positron emission tomography in advanced croronary artery disease (1996) Am Heart J, 131, pp. 440-450
Weich, H.F., Strauss, H.W., Pitt, B., The extraction of thallium-201 by the myocardium (1977) Circulation, 56, pp. 188-191
Grunwald, A.M., Watson, D.D., Holzgrefe, H.H., Irving, J.F., Beller, G.A., Myocardial thallium-201 kinetics in normal and ischemic myocardium (1981) Circulation, 64, pp. 610-618
Uren, G.N.B., Melin, J.A., De Bruyne, B., Wijns, W., Baudhuin, T., Camici, P.G., Relation between blood flow and the severity of coronary artery stenosis (1994) N Engl J Med, 330, pp. 1782-1788
Gibson, R. S., Watson, D. D., Taylor, G. J., Prospective assessment of regional myocardial perfusion before and after coronary revascularization surgery by quantitative thallium-201 scintigraphy (1983) J Am Coll Cardiol, 1, pp. 804-81
Melin, J. A., Wijns, W., Keyeux, A., Assessment of thallium-201 redistribution versus glucose uptake as a predictor of viability after coronary occlusion and reperfusion (1988) Circulation, 77, pp. 927-934
Sabia, P. J., Powers, E. R., Ragosta, M., Smith, W. H., Watson, D. D., Kaul, S., Role of quantitative planar thallium-201 imaging for determining viability in patients with acute myocardial infarction and a totally occluded infarct-related artery (1993) J Nucl Med, 34, pp. 728-736
Liu, P., Kiess, M. C., Okada, R. D., The persistent defect on exercise thallium imaging and its fate after myocardial revascularization: Does it represent scar or ischemia (1985) Am Heart J, 110, pp. 996-1001
Bax, J. J., Cornel, J. H., Visser, F. C., Prediction of recovery of myocardial dysfunction after revascularization. Comparison of fluorine-18 fluorodeoxyglucose/thallium-201 SPECT, thallium-201 stress-reinjection SPECT and dobutamine echocardiography (1996) J Am Coll Cardiol, 28, pp. 558-564
Vanoverschelde, J. L. J., D'Hondt, A. M., Marwivk, T., Head-to head comparison of exercise-redistribution-reinjection thallium single-photon emission computed tomograhy and low dose dobutamine echocardiography for prediction of reversibility of chronic left ventricular ischemic dysfunction (1996) J Am Coll Cardiol, 28, pp. 432-442
Schiller, N. B., Shaha, P. M., Crawford, M., Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echocardiogr, 2, pp. 358-367
Berger, B. C., Watson, D. D., Burwell, L. R., Redistribution of thallium at rest with stable and unstable angina and the effect of coronary artery bypass surgery (1979) Circulation, 60, pp. 1114-1125
Iskandrian, A. S., Hakki, A., Kane, S. A., Rest and redistribution thallium-201 myocardial scintigraphy to predict improvement in left ventricular function after coronary arterial bypass grafting (1983) Am J Cardiol, 51, pp. 1312-1316
Udelson, J. E., Coleman, P. S., Metherall, J., Predicting recovery of severe regional dysfunction. Comparison of resting scintigraphy with thallium-201 and technetium-99m-sestamibi (1994) Circulation, 89, pp. 2552-2561
Matinho, N. V. S., Keogh, B. E., Costa, D. C., Lammerstma, A. A., Ell, P. J., Camici, P. G., Pathophysiology of chronic left ventricular dysfunction. New insight from the measurement of absolute myocardial blood flow and glucose utilization (1996) Circulation, 93, pp. 737-744
Weich, H. F., Strauss, H. W., Pitt, B., The extraction of thallium-201 by the myocardium (1977) Circulation, 56, pp. 188-191
Grunwald, A. M., Watson, D. D., Holzgrefe, H. H., Irving, J. F., Beller, G. A., Myocardial thallium-201 kinetics in normal and ischemic myocardium (1981) Circulation, 64, pp. 610-618
Uren, G. N. B., Melin, J. A., De Bruyne, B., Wijns, W., Baudhuin, T., Camici, P. G., Relation between blood flow and the severity of coronary artery stenosis (1994) N Engl J Med, 330, pp. 1782-1788
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Nov; 39(11): 1869-1874.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.064, 5-year impact factor: 5.331
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031742139&partnerID=40&md5=430c757df72ee8d3be6fd24d5ed7408b
Keywords: Myocardial Viability, Thallium-201, Thresholds, Thallium 201, Adult, Aged, Article, Cell Viability, Clinical Article, Controlled Study, Coronary Artery Disease, Diagnostic Accuracy, Echocardiography, Female, Heart Ejection Fraction, Heart Muscle, Heart Muscle Revascularization, Human, Image Analysis, Priority Journal, Prognosis, Single Photon Emission Computer Tomography, Statistical Analysis, Validation Process, Case-Control Studies, Coronary Disease, Image Processing, Computer-Assisted, Middle Aged, Myocardial Revascularization, Roc Curve, Sensitivity And Specificity, Thallium Radioisotopes, Emission-Computed, Single-Photon,
Affiliations:
trav.priv. Sanseverino 5/A, 80128, Napoli, Italy
trav. priv. Sanseverino 5/A, 80128, Napoli, Italy
References:
Gibson, R.S., Watson, D.D., Taylor, G.J., Prospective assessment of regional myocardial perfusion before and after coronary revascularization surgery by quantitative thallium-201 scintigraphy (1983) J Am Coll Cardiol, 1, pp. 804-81
Melin, J.A., Wijns, W., Keyeux, A., Assessment of thallium-201 redistribution versus glucose uptake as a predictor of viability after coronary occlusion and reperfusion (1988) Circulation, 77, pp. 927-934
Yamamoto, K., Asada, S., Masuyama, T., Myocardial hibernation in the infarcted region cannot be assessed from the presence of stress-induced ischemia: Usefulness of delayed image of exercise thallium-201 (1993) Am Heart J, 125, pp. 33-40
Sabia, P.J., Powers, E.R., Ragosta, M., Smith, W.H., Watson, D.D., Kaul, S., Role of quantitative planar thallium-201 imaging for determining viability in patients with acute myocardial infarction and a totally occluded infarct-related artery (1993) J Nucl Med, 34, pp. 728-736
Liu, P., Kiess, M.C., Okada, R.D., The persistent defect on exercise thallium imaging and its fate after myocardial revascularization: Does it represent scar or ischemia (1985) Am Heart J, 110, pp. 996-1001
Kiat, H., Berman, D.S., Maddahy, J., Late reversibility of tomographic myocardial thallium-201 defects: An accurate marker of myocardial viability (1988) J Am Coll Cardiol, 12, pp. 1456-1463
Dilsizian, V., Rocco, T.P., Freeman, N.M., Leon, M.B., Bonow, R.O., Enhanced detection of ischemic but viable myocardium by the reinjection of thallium after stress-redistribution imaging (1990) N Engl J Med, 323, pp. 141-146
Ohtani, H., Tamaki, N., Yonekura, Y., Value of thallium-201 reinjection after delayed SPECT imaging for predicting reversible ischemia after coronary artery bypass grafting (1990) Am J Cardiol, 66, pp. 394-399
Ragosta, M., Beller, G.A., Watson, D.D., Kaul, S., Gimple, L.W., Quantitative planar rest-redistribution thallium-201 imaging in detection of myocardial viability and prediction of improvement in left ventricular function after coronary bypass surgery in patients with severely depressed left ventricular function (1993) Circulation, 87, pp. 1630-1641
Bax, J.J., Cornel, J.H., Visser, F.C., Prediction of recovery of myocardial dysfunction after revascularization. Comparison of fluorine-18 fluorodeoxyglucose/thallium-201 SPECT, thallium-201 stress-reinjection SPECT and dobutamine echocardiography (1996) J Am Coll Cardiol, 28, pp. 558-564
Arnese, M., Cornel, J.H., Salustri, A., Prediction of improvement of regional left ventricular function after surgical revascularization. A comparison of low-dose dobutamine echocardiography with single-photon emission computed tomography (1995) Circulation, 91, pp. 2748-2752
Haque, T., Furukawa, T., Takahashi, M., Kinoshita, M., Identification of hibernating myocardium by dobutamine stress echocardiography: Comparison with thallium-201 reinjection imaging (1995) Am Heart J, 130, pp. 553-563
Vanoverschelde, J.L.J., D'Hondt, A.M., Marwivk, T., Head-to head comparison of exercise-redistribution-reinjection thallium single-photon emission computed tomograhy and low dose dobutamine echocardiography for prediction of reversibility of chronic left ventricular ischemic dysfunction (1996) J Am Coll Cardiol, 28, pp. 432-442
Matsunari, I., Fujino, S., Taki, J., Quantitative rest technetium-99m tetrofosmin imaging in predicting functional recovery after revascularization: Comparison with rest-redistribution thallium-201 (1997) J Am Coll Cardiol, 29, pp. 1226-1233
Perrone-Filardi, P., Pace, L., Prastaro, M., Dobutamine echocardiography predicts improvement of hypoperfused dysfunctional myocardium after revascularization in patients with coronary artery disease (1995) Circulation, 91, pp. 2556-2565
Schiller, N.B., Shaha, P.M., Crawford, M., Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echocardiogr, 2, pp. 358-367
Berger, B.C., Watson, D.D., Burwell, L.R., Redistribution of thallium at rest with stable and unstable angina and the effect of coronary artery bypass surgery (1979) Circulation, 60, pp. 1114-1125
Iskandrian, A.S., Hakki, A., Kane, S.A., Rest and redistribution thallium-201 myocardial scintigraphy to predict improvement in left ventricular function after coronary arterial bypass grafting (1983) Am J Cardiol, 51, pp. 1312-1316
Udelson, J.E., Coleman, P.S., Metherall, J., Predicting recovery of severe regional dysfunction. Comparison of resting scintigraphy with thallium-201 and technetium-99m-sestamibi (1994) Circulation, 89, pp. 2552-2561
Qureshi, U., Nagueh, S.F., Afridi, I., Dobutamine echocardiography and quantitative rest-redistribution 201Tl tomography in myocardial hibernation. Relation of contractile reserve to 201Tl uptake and comparative prediction of recovery of function (1997) Circulation, 95, pp. 626-635
Matinho, N.V.S., Keogh, B.E., Costa, D.C., Lammerstma, A.A., Ell, P.J., Camici, P.G., Pathophysiology of chronic left ventricular dysfunction. New insight from the measurement of absolute myocardial blood flow and glucose utilization (1996) Circulation, 93, pp. 737-744
Coversano, A., Walsh, J.F., Geltman, E.M., Perez, J.E., Bergmann, S.R., Gropler, R.J., Delineation of myocardial stunning and hibernation by positron emission tomography in advanced croronary artery disease (1996) Am Heart J, 131, pp. 440-450
Weich, H.F., Strauss, H.W., Pitt, B., The extraction of thallium-201 by the myocardium (1977) Circulation, 56, pp. 188-191
Grunwald, A.M., Watson, D.D., Holzgrefe, H.H., Irving, J.F., Beller, G.A., Myocardial thallium-201 kinetics in normal and ischemic myocardium (1981) Circulation, 64, pp. 610-618
Uren, G.N.B., Melin, J.A., De Bruyne, B., Wijns, W., Baudhuin, T., Camici, P.G., Relation between blood flow and the severity of coronary artery stenosis (1994) N Engl J Med, 330, pp. 1782-1788
Gibson, R. S., Watson, D. D., Taylor, G. J., Prospective assessment of regional myocardial perfusion before and after coronary revascularization surgery by quantitative thallium-201 scintigraphy (1983) J Am Coll Cardiol, 1, pp. 804-81
Melin, J. A., Wijns, W., Keyeux, A., Assessment of thallium-201 redistribution versus glucose uptake as a predictor of viability after coronary occlusion and reperfusion (1988) Circulation, 77, pp. 927-934
Sabia, P. J., Powers, E. R., Ragosta, M., Smith, W. H., Watson, D. D., Kaul, S., Role of quantitative planar thallium-201 imaging for determining viability in patients with acute myocardial infarction and a totally occluded infarct-related artery (1993) J Nucl Med, 34, pp. 728-736
Liu, P., Kiess, M. C., Okada, R. D., The persistent defect on exercise thallium imaging and its fate after myocardial revascularization: Does it represent scar or ischemia (1985) Am Heart J, 110, pp. 996-1001
Bax, J. J., Cornel, J. H., Visser, F. C., Prediction of recovery of myocardial dysfunction after revascularization. Comparison of fluorine-18 fluorodeoxyglucose/thallium-201 SPECT, thallium-201 stress-reinjection SPECT and dobutamine echocardiography (1996) J Am Coll Cardiol, 28, pp. 558-564
Vanoverschelde, J. L. J., D'Hondt, A. M., Marwivk, T., Head-to head comparison of exercise-redistribution-reinjection thallium single-photon emission computed tomograhy and low dose dobutamine echocardiography for prediction of reversibility of chronic left ventricular ischemic dysfunction (1996) J Am Coll Cardiol, 28, pp. 432-442
Schiller, N. B., Shaha, P. M., Crawford, M., Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echocardiogr, 2, pp. 358-367
Berger, B. C., Watson, D. D., Burwell, L. R., Redistribution of thallium at rest with stable and unstable angina and the effect of coronary artery bypass surgery (1979) Circulation, 60, pp. 1114-1125
Iskandrian, A. S., Hakki, A., Kane, S. A., Rest and redistribution thallium-201 myocardial scintigraphy to predict improvement in left ventricular function after coronary arterial bypass grafting (1983) Am J Cardiol, 51, pp. 1312-1316
Udelson, J. E., Coleman, P. S., Metherall, J., Predicting recovery of severe regional dysfunction. Comparison of resting scintigraphy with thallium-201 and technetium-99m-sestamibi (1994) Circulation, 89, pp. 2552-2561
Matinho, N. V. S., Keogh, B. E., Costa, D. C., Lammerstma, A. A., Ell, P. J., Camici, P. G., Pathophysiology of chronic left ventricular dysfunction. New insight from the measurement of absolute myocardial blood flow and glucose utilization (1996) Circulation, 93, pp. 737-744
Weich, H. F., Strauss, H. W., Pitt, B., The extraction of thallium-201 by the myocardium (1977) Circulation, 56, pp. 188-191
Grunwald, A. M., Watson, D. D., Holzgrefe, H. H., Irving, J. F., Beller, G. A., Myocardial thallium-201 kinetics in normal and ischemic myocardium (1981) Circulation, 64, pp. 610-618
Uren, G. N. B., Melin, J. A., De Bruyne, B., Wijns, W., Baudhuin, T., Camici, P. G., Relation between blood flow and the severity of coronary artery stenosis (1994) N Engl J Med, 330, pp. 1782-1788
Identification of viable myocardium in patients with chronic coronary artery disease using rest-redistribution thallium-201 tomography: Optimal image analysis
With the widely used 50% threshold, sensitivity is high, but specificity is low in detecting viable myocardium on Tl-201 SPECT, In this study, we sought to identify the best threshold for semiquantitative Tl-201 analysis, Methods: Rest-redistribution Tl-201 SPECT was performed in 46 patients with chronic coronary artery disease before and after myocardial revascularization, Regional function was evaluated by two-dimensional echocardiography before and after myocardial revascularization using a 3-point scale (1 = normal, 2 = hypokinetic, 3 = a/dyskinetic), Myocardial segments with abnormal systolic function were defined as viable if the systolic function score decreased greater than or equal to 1 after myocardial revascularization, A second group of 12 patients with chronic coronary artery disease constituted the validation population. Sensitivity-specificity curves, as well as receiver operating characteristic curves, for rest and redistribution images were generated by varying the Tl-201 uptake threshold. Results: A 65% threshold uptake using resting images was found to be the best for detecting a/dyskinetic segments that improve after myocardial revascularization from those that do not improve. Sensitivity was lower with a 65% threshold (75%) than with a 50% threshold (90%, p < 0.05), but specificity was higher (76% versus 26%, p < 0.05) resulting in better accuracy (76% versus 57%, p < 0.05) and positive predictive value (77% versus 55%), while the negative predictive value was not different (69% versus 75%, p not significant). The area under the receiver operating characteristic curve was significantly (p < 005) larger for rest (0.80 +/- 0.05) as opposed to redistribution (0.72 +/- 0.05) images. Similar results were obtained in a subgroup of patients with low ejection fraction. Significant correlations between the percentage of revascularized viable segments and both the change in ejection fraction and in postrevascularization ejection fraction were found. When these findings were applied in the validation group, a gain in specificity accuracy and positive predictive value was obtained with the 65% threshold compared with the 50% threshold. Conclusion: This study demonstrated that analysis of resting images and use of the 65% Tl-201 uptake threshold is preferable for separating viable from not viable dyssynergic myocardial segments in patients with chronic coronary artery disease.
With the widely used 50% threshold, sensitivity is high, but specificity is low in detecting viable myocardium on Tl-201 SPECT, In this study, we sought to identify the best threshold for semiquantitative Tl-201 analysis, Methods: Rest-redistribution Tl-201 SPECT was performed in 46 patients with chronic coronary artery disease before and after myocardial revascularization, Regional function was evaluated by two-dimensional echocardiography before and after myocardial revascularization using a 3-point scale (1 = normal, 2 = hypokinetic, 3 = a/dyskinetic), Myocardial segments with abnormal systolic function were defined as viable if the systolic function score decreased greater than or equal to 1 after myocardial revascularization, A second group of 12 patients with chronic coronary artery disease constituted the validation population. Sensitivity-specificity curves, as well as receiver operating characteristic curves, for rest and redistribution images were generated by varying the Tl-201 uptake threshold. Results: A 65% threshold uptake using resting images was found to be the best for detecting a/dyskinetic segments that improve after myocardial revascularization from those that do not improve. Sensitivity was lower with a 65% threshold (75%) than with a 50% threshold (90%, p < 0.05), but specificity was higher (76% versus 26%, p < 0.05) resulting in better accuracy (76% versus 57%, p < 0.05) and positive predictive value (77% versus 55%), while the negative predictive value was not different (69% versus 75%, p not significant). The area under the receiver operating characteristic curve was significantly (p < 005) larger for rest (0.80 +/- 0.05) as opposed to redistribution (0.72 +/- 0.05) images. Similar results were obtained in a subgroup of patients with low ejection fraction. Significant correlations between the percentage of revascularized viable segments and both the change in ejection fraction and in postrevascularization ejection fraction were found. When these findings were applied in the validation group, a gain in specificity accuracy and positive predictive value was obtained with the 65% threshold compared with the 50% threshold. Conclusion: This study demonstrated that analysis of resting images and use of the 65% Tl-201 uptake threshold is preferable for separating viable from not viable dyssynergic myocardial segments in patients with chronic coronary artery disease.
Identification of viable myocardium in patients with chronic coronary artery disease using rest-redistribution thallium-201 tomography: Optimal image analysis
| ▼ Comparison of noninvasive cardiac imaging modalities in patients with myocardial infarction |
Identification of viable myocardium in patients with chronic coronary artery disease using rest-redistribution thallium-201 tomography: Optimal image analysis
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Acs Chem Biol (ISSN: 1554-8929), 2015; 10(4): 965-969.
Impact Factor: 5.09
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (559 views)
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Impact Factor: 3.65
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
* The role of copper(II) in the aggregation of human amylin (492 views)
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Impact Factor: 3.585
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (595 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Russo E, Guerra A, Marotta V, Faggiano A, Colao A, Del Vecchio S, Tonacchera M, Vitale M
* Radioiodide induces apoptosis in human thyroid tissue in culture (363 views)
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2013 Dec; 44(3): 729-734.
Impact Factor: 3.527
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Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (441 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
Impact Factor: 3.274
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (439 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (546 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
* Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (367 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
Impact Factor: 2.689
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (410 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Perrone-filardi P, Cuocolo A, Dellegrottaglie S
Myocardial perfusion imaging in very elderly patients with suspected coronary artery disease: never too late! (387 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2012 Apr; 19(2): 224-226.
Impact Factor: 2.847
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (893 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Gargiulo P, Petretta M, Bruzzese D, Cuocolo A, Prastaro M, D'Amore C, Vassallo E, Savarese G, Marciano C, Paolillo S, Filardi PP
* Myocardial perfusion scintigraphy and echocardiography for detecting coronary artery disease in hypertensive patients: a meta-analysis (312 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 Nov; 38(11): 2040-2049.
Impact Factor: 4.991
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Spadafora M, Varrella P, Acampa W, Spirito M, Nappi C, Mansi L, Miletto P, Rosato G, Cuocolo A
* Direct imaging of viable myocardium by gated SPECT in patients with ischaemic left ventricular dysfunction (417 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Sep; 37(9): 1730-1735.
Impact Factor: 5.036
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (698 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Lucignani G, Cuocolo A
Recent advances in the assessment of myocardial viability (396 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2009 Nov; 36(11): 1892-1895.
Impact Factor: 4.531
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Evangelista L, Acampa W, Petretta M, Ferro A, Ricci F, Luongo L, Daniele S, Punzo G, Cuocolo A
* Incremental prognostic value of cardiac single-photon emission computed tomography after nitrate administration in patients with ischemic left ventricular dysfunction (452 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2009 Feb; 16(1): 38-44.
Impact Factor: 2.777
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Petretta M, Costanzo P, Acampa W, Imbriaco M, Ferro A, Filardi PP, Cuocolo A
* Noninvasive assessment of coronary anatomy and myocardial perfusion: Going toward an integrated imaging approach (400 views)
J Cardiovasc Med (ISSN: 1558-2027, 1558-2035), 2008 Oct; 9(10): 977-986.
Impact Factor: 1.407
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Palumbo R, Brescia F, Capasso D, Sannino A, Sarti M, Capri M, Grassilli E, Scarfì MR
* Exposure to 900 MHz radiofrequency radiation induces caspase 3 activation in proliferating human lymphocytes (445 views)
Radiat Res (ISSN: 0033-7587), 2008 Sep; 170(3): 327-334.
Impact Factor: 3.043
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Acampa W, Evangelista L, Sorrentino AR, Petretta M, Luongo L, Cuocolo A
* Single-Photon Emission Computed Tomography After Nitrate Administration Predicts Cardiac Events in Patients With Previous Myocardial Infarction and Left Ventricular Dysfunction (248 views)
J Card Fail (ISSN: 1071-9164, 1532-8414), 2007 Nov; 13(9): 765-768.
Impact Factor: 3.067
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Cuocolo A
FDG imaging should be considered the preferred technique for accurate assessment of myocardial viability: against (268 views)
Eur J Nucl Med (ISSN: 1619-7070print, 1619-7070linking, 1619-7089electronic), 2005 Jul; 32(7): 832-835.
Impact Factor: 3.883
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Acampa W, Petretta M, Spinelli L, Ibello F, De Lauro F, Sansone V, Salvatore M, Cuocolo A
* Survival benefit after revascularization is independent of left ventricular ejection fraction improvement in patients with previous myocardial infarction and viable myocardium (470 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Apr; 32(4): 430-437.
Impact Factor: 3.883
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Dellegrottaglie S, Perrone-filardi P, Pace L, Prastaro M, Corrado L, Cafiero M, Della Morte AM, Zarrilli A, Camerino R, Polimeno M, Chiarillo M
* The identification of reversible dysfunctional myocardium is influenced by the severity of contractile dysfunction and by the length of follow-up (276 views)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2005 Apr; 26(4): 337-343.
Impact Factor: 1.097
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Cuocolo A, Acampa W, Imbriaco M, De Luca N, Iovino GL, Salvatore M
* The many ways to myocardial perfusion imaging (478 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2005 Mar; 49(1): 4-18.
Impact Factor: 1.724
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (752 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
* 3. 0 T perfusion MR imaging (731 views)
Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812.
Impact Factor: 0.023
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Piscione F, De Luca G, Perrone-filardi P, Prastaro M, Pace L, Galasso G, Marrazzo G, Salvatore M, Chiariello M
* Relationship between contractile reserve, TI-201 uptake, and collateral angiographic circulation in collateral-dependent myocardium: Implications regarding the evaluation of myocardial viability (497 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2003 Jan; 10(1): 17-27.
Impact Factor: 1.629
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (536 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Cuocolo A, Acampa W, Evangelista L
* Nuclear medicine and positron emission tomography imaging in cardiology (401 views)
Nucl Med Rev (ISSN: 1506-9680), 2003; 6(1): 59-63.
Impact Factor: 0.155
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (657 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (468 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Acampa W, He W, di Nuzzo C, Cuocolo A
* Quantification of SPECT myocardial perfusion imaging (356 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 May; 9(3): 338-342.
Impact Factor: 1.167
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Dellegrottaglie S, Perrone-Filardi P, Pace L, Prastaro M, Della Morte AM, Ponticelli MP, Piscione F, Storto G, De Luca G, Salvatore M, Chiariello M
* Prediction of long-term effects of revascularization on regional and global left ventricular function by dobutamine echocardiography and rest TI-201 imaging alone and in combination in patients with chronic coronary artery disease (342 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 Mar; 9(2): 174-182.
Impact Factor: 1.167
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Acampa W, Cuocolo A, Petretta M, Bruno A, Castellani M, Finzi A, Gerundini P
* Tetrofosmin imaging in the detection of myocardial viability in patients with previous myocardial infarction: Comparison with sestamibi and Tl-201 scintigraphy (309 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 Jan; 9(1): 33-40.
Impact Factor: 1.167
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Pace L, Filardi PP, Cuocolo A, Prastaro M, Acampa W, Dellegrottaglie S, Storto G, Della Morte AM, Piscione F, Chiariello M, Salvatore M
* Diagnostic accuracy of low-dose dobutamine echocardiography in predicting post-revascularisation recovery of function in patients with chronic coronary artery disease: Relationship to thallium-201 uptake (264 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Nov; 28(11): 1616-1623.
Impact Factor: 3.464
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Acampa W, Petretta M, Cuocolo A
* Myocardial viability assessment in regions of left ventricular dysfunction. Part II: The present and future of echocardiography and magnetic resonance imaging (254 views)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2001 Jul; 22(7): 731-735.
Impact Factor: 1.19
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Petretta M, Acampa W, Cuocolo A
* Myocardial viability assessment in regions of left ventricular dysfunction. Part I: Radionuclide imaging and clinical implications (348 views)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2001 Jun; 22(6): 607-611.
Impact Factor: 1.19
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Cuocolo A, Acampa W
* Nuclear cardiology in the new millennium (324 views)
Rev Esp Med Nucl (ISSN: 0212-6982), 2001 Jun; 20(4): 305-308.
Impact Factor: 0.155
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Pace L, Perrone-Filardi P, Storto G, Della Morte AM, Dellegrottaglie S, Prastaro M, Crisci T, Ponticelli MP, Piscione F, Chiariello M, Salvatore M
Prediction of improvement in global left ventricular function in patients with chronic coronary artery disease and impaired left ventricular function: Rest thallium-201 SPET versus low-dose dobutamine echocardiography (269 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2000 Dec; 27(12): 1740-1746.
Impact Factor: 3.772
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Acampa W, Di Benedetto C, Cuocolo A
An overview of radiotracers in nuclear cardiology (382 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Nov; 7(6): 701-707.
Impact Factor: 1.854
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Acampa W, Petretta M, Florimonte L, di Santolo MS, Cuocolo A
Sestamibi SPECT in the detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction: Comparison between visual and quantitative analysis (270 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Sep; 7(5): 406-413.
Impact Factor: 1.854
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Cuocolo A, Rubini G, Acampa W, Nicolai E, Florimonte L, DiGiovine G, D'Addabbo A, Salvatore M
Technetium 99m furifosmin regional myocardial uptake in patients with previous myocardial infarction: Relation to thallium-201 activity and left ventricular function (279 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 May; 7(3): 235-241.
Impact Factor: 1.854
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Cuocolo A, Acampa W, Nicolai E, Pace L, Petretta M, Salvatore M
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction (347 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Jan; 7(1): 8-15.
Impact Factor: 1.854
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Menna F, Acampa W, Florimonte L, Ferro A, Borrelli G, Mainolfi C, Cuocolo A
99mTc tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left vetricular dysfunction (333 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 99(4): 258-263.
Impact Factor: 1.368
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Spinelli L, Petretta M, Cuocolo A, Nicolai E, Acampa W, Vicario L, Bonaduce D
Prediction of recovery of left ventricular dysfunction after acute myocardial infarction: Comparison between Tc-99m-sestamibi cardiac tomography and low-dose dobutamine echocardiography (294 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1999 Oct; 40(10): 1683-1692.
Impact Factor: 3.326
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Cuocolo A, Acampa W, Nicolai E, Pace L, Petretta M, Salvatore M
Quantitative thallium-201 and technetium-99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction (254 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1999 Sep; 26(9): N/D-N/D.
Impact Factor: 3.239
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Nicolai E, Cuocolo A, Acampa W, Varrone A, Pace L, Salvatore M
Exercise-test Tc-99m tetrofosmin SPECT in patients with chronic ischemic left ventricular dysfunction: direct comparison with Ti-201 reinjection (303 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1999 May; 6(3): 270-277.
Impact Factor: 1.765
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Gisonni P, Cuocolo A, Spinelli L, Acampa W, Florimonte L, Nicolai E, Petretta M, Sodano A
99mTc sestamibi cardiac tomography and dobutamine echocardiography in the identification of reversible left ventricular dysfunction in patients with acute myocardial infarction (284 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1999 Apr; 97(4): 265-270.
Impact Factor: 0.967
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Petretta M, Cuocolo A, Nicolai E, Acampa W, Salvatore M, Bonaduce D
Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction (454 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1998 Jul; 5(4): 378-386.
Impact Factor: 1.336
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Pace L, Perrone-Filardi P, Mainenti PP, Prastaro M, Vezzuto P, Varrone A, Crisci T, Cuocolo A, Dellegrottaglie S, Piscione F, Chiariello M, Salvatore M
Combined evaluation of rest-redistribution thallium-201 tomography and low-dose dobutamine echocardiography enhances the identification of viable myocardium in patients with chronic coronary artery disease (326 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1998 Jul; 25(7): 744-750.
Impact Factor: 2.564
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Cuocolo A, Petretta M, Nicolai E, Acampa W, Varrone A, Bonaduce D, Salvatore M
Prognostic value of combined assessment of left ventricular function and regional myocardial thallium-201 activity in patients with chronic ischemic left ventricular dysfunction (288 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): N/D-N/D.
Impact Factor: 3.064
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Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging (479 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): 802-806.
Impact Factor: 3.064
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Pace L, Perrone-Filardi P, Mainenti PP, Prastaro M, Cuocolo A, Varrone A, Vezzuto P, Crisci T, Soricelli A, Piscione F, Chiariello M, Salvatore M
Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease (290 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1998 Mar; 5(2): 153-160.
Impact Factor: 1.336
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Cuocolo A, Nicolai E, Petretta M, Morisco C, DeLuca N, Salvatore M, Trimarco B
One-year effect of myocardial revascularization on resting left ventricular function and regional thallium uptake in chronic CAD (366 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Nov; 38(11): 1684-1692.
Impact Factor: 3.491
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Cuocolo A, Nicolai E, Petretta M, Pace L, Cardei S, Varrone A, Trimarco B, Salvatore M
Effects of revascularization on survival and left ventricular function in patients with previous myocardial infarction and evidence of viable myocardium at thallium-201 imaging (246 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Cuocolo A, Petretta M, Nicolai E, Pace L, Acampa W, Varrone A, Bonaduce D, Salvatore M
Prognostic value of coronary angiography in patients with chronic ischemic left ventricular dysfunction and evidence of viable myocardium at thallium-201 reinjection imaging (315 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): 387-395.
Impact Factor: 3.491
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Petretta M, Cuocolo A, Bonaduce D, Nicolai E, Cardei S, Berardino S, Ianniciello A, Apicella C, Bianchi V, Salvatore M
Incremental prognostic value of thallium reinjection after stress- redistribution imaging in patients with previous myocardial infarction and left ventricular dysfunction (332 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Feb; 38(2): 195-200.
Impact Factor: 3.491
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Marcassa C, Galli M, Cuocolo A, Scappellato F, Maurea S, Salvatore M
Rest-redistribution thallium-201 and rest technetium-99m-sestamibi SPECT in patients with stable coronary artery disease and ventricular dysfunction (291 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997; 38(3): 419-424.
Impact Factor: 3.491
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Tedeschi E, Soricelli A, Brunetti A, Romano M, Bucciero A, Iaconetta G, Alfieri A, Postiglione A, Salvatore M
Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas (379 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Nov; 23(11): 1478-1484.
Impact Factor: 2.692
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Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (852 views) (PDF 245 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
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Maurea S, Cuocolo A, Soricelli A, Castelli L, Nappi A, Trimarco B, Salvatore M
Technetium-99m MIBI SPECT to identify viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction (300 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1996; 92(3): 289-296.
Impact Factor: 0.967
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Klain M, Maurea S, Cuocolo A, Colao A, Marzano L, Lombardi G, Salvatore M
Technetium-99m tetrofosmin imaging in thyroid diseases: Comparison with Tc-99m-pertechnetate, thallium-201 and Tc-99m-methioxyisobutylisonitrile scans (307 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996; 23(12): 1568-1574.
Impact Factor: 2.692
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Maurea S, Cuocolo A, Soricelli A, Castelli L, Nappi A, Squame F, Imbriaco M, Trimarco B, Salvatore M
ENHANCED DETECTION OF VIABLE MYOCARDIUM BY TECHNETIUM-99M-MIBI IMAGING AFTER NITRATE ADMINISTRATION IN CHRONIC CORONARY-ARTERY DISEASE (245 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Nov; 36(11): 1945-1952.
Impact Factor: 3.491
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Maurea S, Cuocolo A, Soricelli A, Castelli L, Squame F, Imbriaco M, De Luca N, Trimarco B, Salvatore M
MYOCARDIAL VIABILITY INDEX IN CHRONIC CORONARY-ARTERY DISEASE - TECHNETIUM-99M-METHOXY ISOBUTYL ISONITRILE REDISTRIBUTION (256 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Nov; 36(11): 1953-1960.
Impact Factor: 3.491
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PACE L, CUOCOLO A, MARZULLO P, NICOLAI E, GIMELLI A, DELUCA N, RICCIARDELLI B, SALVATORE M
REVERSE REDISTRIBUTION IN RESTING TL-201 MYOCARDIAL SCINTIGRAPHY IN CHRONIC CORONARY-ARTERY DISEASE - AN INDEX OF MYOCARDIAL VIABILITY (210 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Nov; 36(11): N/D-N/D.
Impact Factor: 3.491
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Nicolai E, Cuocolo A, Pace L, Maurea S, Nappi A, Imbriaco M, Morisco C, Argenziano L, Salvatore M
Assessment of systolic wall thickening using technetium-99m methoxyisobutylisonitrile in patients with coronary artery disease: relation to thallium-201 scintigraphy with re-injection (322 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1995 Sep; 22(9): 1017-1022.
Impact Factor: 2.692
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Pace L, Cuocolo A, Nicolai E, Imbriaco M, Maurea S, Nappi A, Ricciardelli B, Salvatore M
REVERSE REDISTRIBUTION IN TL-201 STRESS-REDISTRIBUTION MYOCARDIAL SCINTIGRAPHY - EFFECT OF REST REINJECTION (271 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1994 Nov; 19(11): 956-961.
Impact Factor: 0.34
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Maurea S, Cuocolo A, Nicolai E, Salvatore M
Improved detection of viable myocardium with thallium-201 reinjection in chronic coronary artery disease: comparison with technetium-99m-MIBI imaging (292 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Apr; 35(4): 621-624.
Impact Factor: 3.491
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Cuocolo A, Pace L, Maurea S, Ricciardelli B, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Enhanced thallium-201 uptake after reinjection: Relation to regional ventricular function, myocardial perfusion and coronary anatomy (247 views)
J Nucl Med Allied Sci, 1994 Mar; 38(1): 6-13.
Impact Factor: 0
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Left ventricular dysfunction in coronary artery disease: Comparison between rest-redistribution thallium 201 and resting technetium 99m methoxyisobutyl isonitrile cardiac imaging (302 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1994 Jan; 1(1): 65-71.
Impact Factor: 1.878
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Cuocolo A, Maurea S, Pace L, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Resting technetium-99m methoxyisobutylisonitrile cardiac imaging in chronic coronary artery disease: comparison with rest-redistribution thallium-201 scintigraphy (323 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1993 Dec; 20(12): 1186-1192.
Impact Factor: 2.692
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Pace L, Cuocolo A, Maurea S, Nicolai E, Imbriaco M, Nappi A, Morisco C, Chiariello M, Trimarco B, Salvatore M
Reverse redistribution in resting thallium-201 myocardial scintigraphy in patients with coronary artery disease: Relation to coronary anatomy and ventricular function (310 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1993 Oct; 34(10): 1688-1692.
Impact Factor: 3.491
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PETRETTA M, BONADUCE D, CUOCOLO A, MORGANO G, NICOLAI E, PULCINO A, BIANCHI V, SALVATORE M
Incremental prognostic value of thallium imaging and coronary angiography in patients with a symptom-limited ECG stress test (394 views)
Coron Artery Dis (ISSN: 0954-6928), 1993 Jul; 4(7): 637-644.
Impact Factor: 0.653
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Morisco C, Chiariello M, Trimarco B, Salvatore M
Rest-injected thallium-201 redistribution and resting technetium-99m methoxyisobutylisonitrile uptake in coronary artery disease: relation to the severity of coronary artery stenosis (279 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1993 Jun; 20(6): 502-510.
Impact Factor: 2.692
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* Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex (136 views)
Pharmaceutics (ISSN: 1999-4923linking), 2020 Jul 4; 12(7): 627-627.
Impact Factor: 4.421
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Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (399 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
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Magrì A, Belfiore R, Reina S, Tomasello MF, Di Rosa MC, Guarino F, Leggio L, De Pinto V, Messina A
* Hexokinase I N-terminal based peptide prevents the VDAC1-SOD1 G93A interaction and re-establishes ALS cell viability (233 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2016 Oct 10; 6: 34802-34802.
Impact Factor: 4.259
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Palumbo R, Gogliettino M, Cocca E, Iannitti R, Sandomenico A, Ruvo M, Balestrieri M, Rossi M, Palmieri G
* APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome (341 views)
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Impact Factor: 3.226
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Colucci-D'Amato L, Cicatiello AE, Reccia MG, Volpicelli F, Severino V, Russo R, Sandomenico A, Doti N, D'Esposito V, Formisano P, Chambery A
* A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells (588 views)
Proteomics (ISSN: 1615-9853), 2015 Feb; 15(4): 714-724.
Impact Factor: 4.079
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Tabbì G, Magrì A, Giuffrida A, Lanza V, Pappalardo G, Naletova I, Nicoletti VG, Attanasio F, Rizzarelli E
* Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity (487 views)
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Impact Factor: 3.205
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Malgieri G, Avitabile C, Palmieri M, D'Andrea LD, Isernia C, Romanelli A, Fattorusso R
* Structural basis of a temporin 1b analogue antimicrobial activity against gram negative bacteria determined by CD and NMR techniques in cellular environment (584 views)
Acs Chem Biol (ISSN: 1554-8929), 2015; 10(4): 965-969.
Impact Factor: 5.09
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (559 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
* The role of copper(II) in the aggregation of human amylin (492 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014 Oct; 6(10): 1841-1852.
Impact Factor: 3.585
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (595 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Russo E, Guerra A, Marotta V, Faggiano A, Colao A, Del Vecchio S, Tonacchera M, Vitale M
* Radioiodide induces apoptosis in human thyroid tissue in culture (363 views)
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2013 Dec; 44(3): 729-734.
Impact Factor: 3.527
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Pellerito O, Prinzivalli C, Foresti E, Sabatino P, Abbate M, Casella G, Fiore T, Scopelliti M, Pellerito C, Giuliano M, Grasso G, Pellerito L
* Synthesis, chemical characterization and biological activity of new histone acetylation/deacetylation specific inhibitors: A novel and potential approach to cancer therapy (441 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2013 Sep; 125: 16-25.
Impact Factor: 3.274
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (439 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (546 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
* Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (367 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
Impact Factor: 2.689
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (410 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Perrone-filardi P, Cuocolo A, Dellegrottaglie S
Myocardial perfusion imaging in very elderly patients with suspected coronary artery disease: never too late! (387 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2012 Apr; 19(2): 224-226.
Impact Factor: 2.847
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (893 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Gargiulo P, Petretta M, Bruzzese D, Cuocolo A, Prastaro M, D'Amore C, Vassallo E, Savarese G, Marciano C, Paolillo S, Filardi PP
* Myocardial perfusion scintigraphy and echocardiography for detecting coronary artery disease in hypertensive patients: a meta-analysis (312 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 Nov; 38(11): 2040-2049.
Impact Factor: 4.991
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Spadafora M, Varrella P, Acampa W, Spirito M, Nappi C, Mansi L, Miletto P, Rosato G, Cuocolo A
* Direct imaging of viable myocardium by gated SPECT in patients with ischaemic left ventricular dysfunction (417 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Sep; 37(9): 1730-1735.
Impact Factor: 5.036
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (698 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Lucignani G, Cuocolo A
Recent advances in the assessment of myocardial viability (396 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2009 Nov; 36(11): 1892-1895.
Impact Factor: 4.531
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Evangelista L, Acampa W, Petretta M, Ferro A, Ricci F, Luongo L, Daniele S, Punzo G, Cuocolo A
* Incremental prognostic value of cardiac single-photon emission computed tomography after nitrate administration in patients with ischemic left ventricular dysfunction (452 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2009 Feb; 16(1): 38-44.
Impact Factor: 2.777
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Petretta M, Costanzo P, Acampa W, Imbriaco M, Ferro A, Filardi PP, Cuocolo A
* Noninvasive assessment of coronary anatomy and myocardial perfusion: Going toward an integrated imaging approach (400 views)
J Cardiovasc Med (ISSN: 1558-2027, 1558-2035), 2008 Oct; 9(10): 977-986.
Impact Factor: 1.407
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Palumbo R, Brescia F, Capasso D, Sannino A, Sarti M, Capri M, Grassilli E, Scarfì MR
* Exposure to 900 MHz radiofrequency radiation induces caspase 3 activation in proliferating human lymphocytes (445 views)
Radiat Res (ISSN: 0033-7587), 2008 Sep; 170(3): 327-334.
Impact Factor: 3.043
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Acampa W, Evangelista L, Sorrentino AR, Petretta M, Luongo L, Cuocolo A
* Single-Photon Emission Computed Tomography After Nitrate Administration Predicts Cardiac Events in Patients With Previous Myocardial Infarction and Left Ventricular Dysfunction (248 views)
J Card Fail (ISSN: 1071-9164, 1532-8414), 2007 Nov; 13(9): 765-768.
Impact Factor: 3.067
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Cuocolo A
FDG imaging should be considered the preferred technique for accurate assessment of myocardial viability: against (268 views)
Eur J Nucl Med (ISSN: 1619-7070print, 1619-7070linking, 1619-7089electronic), 2005 Jul; 32(7): 832-835.
Impact Factor: 3.883
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Acampa W, Petretta M, Spinelli L, Ibello F, De Lauro F, Sansone V, Salvatore M, Cuocolo A
* Survival benefit after revascularization is independent of left ventricular ejection fraction improvement in patients with previous myocardial infarction and viable myocardium (470 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Apr; 32(4): 430-437.
Impact Factor: 3.883
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Dellegrottaglie S, Perrone-filardi P, Pace L, Prastaro M, Corrado L, Cafiero M, Della Morte AM, Zarrilli A, Camerino R, Polimeno M, Chiarillo M
* The identification of reversible dysfunctional myocardium is influenced by the severity of contractile dysfunction and by the length of follow-up (276 views)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2005 Apr; 26(4): 337-343.
Impact Factor: 1.097
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Cuocolo A, Acampa W, Imbriaco M, De Luca N, Iovino GL, Salvatore M
* The many ways to myocardial perfusion imaging (478 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2005 Mar; 49(1): 4-18.
Impact Factor: 1.724
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (752 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R
* 3. 0 T perfusion MR imaging (731 views)
Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812.
Impact Factor: 0.023
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Piscione F, De Luca G, Perrone-filardi P, Prastaro M, Pace L, Galasso G, Marrazzo G, Salvatore M, Chiariello M
* Relationship between contractile reserve, TI-201 uptake, and collateral angiographic circulation in collateral-dependent myocardium: Implications regarding the evaluation of myocardial viability (497 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2003 Jan; 10(1): 17-27.
Impact Factor: 1.629
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (536 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Cuocolo A, Acampa W, Evangelista L
* Nuclear medicine and positron emission tomography imaging in cardiology (401 views)
Nucl Med Rev (ISSN: 1506-9680), 2003; 6(1): 59-63.
Impact Factor: 0.155
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (657 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (468 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Acampa W, He W, di Nuzzo C, Cuocolo A
* Quantification of SPECT myocardial perfusion imaging (356 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 May; 9(3): 338-342.
Impact Factor: 1.167
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Dellegrottaglie S, Perrone-Filardi P, Pace L, Prastaro M, Della Morte AM, Ponticelli MP, Piscione F, Storto G, De Luca G, Salvatore M, Chiariello M
* Prediction of long-term effects of revascularization on regional and global left ventricular function by dobutamine echocardiography and rest TI-201 imaging alone and in combination in patients with chronic coronary artery disease (342 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 Mar; 9(2): 174-182.
Impact Factor: 1.167
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Acampa W, Cuocolo A, Petretta M, Bruno A, Castellani M, Finzi A, Gerundini P
* Tetrofosmin imaging in the detection of myocardial viability in patients with previous myocardial infarction: Comparison with sestamibi and Tl-201 scintigraphy (309 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2002 Jan; 9(1): 33-40.
Impact Factor: 1.167
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Pace L, Filardi PP, Cuocolo A, Prastaro M, Acampa W, Dellegrottaglie S, Storto G, Della Morte AM, Piscione F, Chiariello M, Salvatore M
* Diagnostic accuracy of low-dose dobutamine echocardiography in predicting post-revascularisation recovery of function in patients with chronic coronary artery disease: Relationship to thallium-201 uptake (264 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Nov; 28(11): 1616-1623.
Impact Factor: 3.464
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Acampa W, Petretta M, Cuocolo A
* Myocardial viability assessment in regions of left ventricular dysfunction. Part II: The present and future of echocardiography and magnetic resonance imaging (254 views)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2001 Jul; 22(7): 731-735.
Impact Factor: 1.19
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Petretta M, Acampa W, Cuocolo A
* Myocardial viability assessment in regions of left ventricular dysfunction. Part I: Radionuclide imaging and clinical implications (348 views)
Nuclear Medicine Communications (ISSN: 0143-3636, 1473-5628), 2001 Jun; 22(6): 607-611.
Impact Factor: 1.19
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Cuocolo A, Acampa W
* Nuclear cardiology in the new millennium (324 views)
Rev Esp Med Nucl (ISSN: 0212-6982), 2001 Jun; 20(4): 305-308.
Impact Factor: 0.155
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Pace L, Perrone-Filardi P, Storto G, Della Morte AM, Dellegrottaglie S, Prastaro M, Crisci T, Ponticelli MP, Piscione F, Chiariello M, Salvatore M
Prediction of improvement in global left ventricular function in patients with chronic coronary artery disease and impaired left ventricular function: Rest thallium-201 SPET versus low-dose dobutamine echocardiography (269 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2000 Dec; 27(12): 1740-1746.
Impact Factor: 3.772
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Acampa W, Di Benedetto C, Cuocolo A
An overview of radiotracers in nuclear cardiology (382 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Nov; 7(6): 701-707.
Impact Factor: 1.854
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Acampa W, Petretta M, Florimonte L, di Santolo MS, Cuocolo A
Sestamibi SPECT in the detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction: Comparison between visual and quantitative analysis (270 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Sep; 7(5): 406-413.
Impact Factor: 1.854
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Cuocolo A, Rubini G, Acampa W, Nicolai E, Florimonte L, DiGiovine G, D'Addabbo A, Salvatore M
Technetium 99m furifosmin regional myocardial uptake in patients with previous myocardial infarction: Relation to thallium-201 activity and left ventricular function (279 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 May; 7(3): 235-241.
Impact Factor: 1.854
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Cuocolo A, Acampa W, Nicolai E, Pace L, Petretta M, Salvatore M
Quantitative thallium-201 and technetium 99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction (347 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Jan; 7(1): 8-15.
Impact Factor: 1.854
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Menna F, Acampa W, Florimonte L, Ferro A, Borrelli G, Mainolfi C, Cuocolo A
99mTc tetrofosmin cardiac tomography after nitrate administration in patients with coronary artery disease and left vetricular dysfunction (333 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2000; 99(4): 258-263.
Impact Factor: 1.368
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Spinelli L, Petretta M, Cuocolo A, Nicolai E, Acampa W, Vicario L, Bonaduce D
Prediction of recovery of left ventricular dysfunction after acute myocardial infarction: Comparison between Tc-99m-sestamibi cardiac tomography and low-dose dobutamine echocardiography (294 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1999 Oct; 40(10): 1683-1692.
Impact Factor: 3.326
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Cuocolo A, Acampa W, Nicolai E, Pace L, Petretta M, Salvatore M
Quantitative thallium-201 and technetium-99m sestamibi tomography at rest in detection of myocardial viability in patients with chronic ischemic left ventricular dysfunction (254 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1999 Sep; 26(9): N/D-N/D.
Impact Factor: 3.239
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Nicolai E, Cuocolo A, Acampa W, Varrone A, Pace L, Salvatore M
Exercise-test Tc-99m tetrofosmin SPECT in patients with chronic ischemic left ventricular dysfunction: direct comparison with Ti-201 reinjection (303 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1999 May; 6(3): 270-277.
Impact Factor: 1.765
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Gisonni P, Cuocolo A, Spinelli L, Acampa W, Florimonte L, Nicolai E, Petretta M, Sodano A
99mTc sestamibi cardiac tomography and dobutamine echocardiography in the identification of reversible left ventricular dysfunction in patients with acute myocardial infarction (284 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1999 Apr; 97(4): 265-270.
Impact Factor: 0.967
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Petretta M, Cuocolo A, Nicolai E, Acampa W, Salvatore M, Bonaduce D
Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction (454 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1998 Jul; 5(4): 378-386.
Impact Factor: 1.336
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Pace L, Perrone-Filardi P, Mainenti PP, Prastaro M, Vezzuto P, Varrone A, Crisci T, Cuocolo A, Dellegrottaglie S, Piscione F, Chiariello M, Salvatore M
Combined evaluation of rest-redistribution thallium-201 tomography and low-dose dobutamine echocardiography enhances the identification of viable myocardium in patients with chronic coronary artery disease (326 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1998 Jul; 25(7): 744-750.
Impact Factor: 2.564
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Cuocolo A, Petretta M, Nicolai E, Acampa W, Varrone A, Bonaduce D, Salvatore M
Prognostic value of combined assessment of left ventricular function and regional myocardial thallium-201 activity in patients with chronic ischemic left ventricular dysfunction (288 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): N/D-N/D.
Impact Factor: 3.064
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Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging (479 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 May; 39(5): 802-806.
Impact Factor: 3.064
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Pace L, Perrone-Filardi P, Mainenti PP, Prastaro M, Cuocolo A, Varrone A, Vezzuto P, Crisci T, Soricelli A, Piscione F, Chiariello M, Salvatore M
Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease (290 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1998 Mar; 5(2): 153-160.
Impact Factor: 1.336
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Cuocolo A, Nicolai E, Petretta M, Morisco C, DeLuca N, Salvatore M, Trimarco B
One-year effect of myocardial revascularization on resting left ventricular function and regional thallium uptake in chronic CAD (366 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Nov; 38(11): 1684-1692.
Impact Factor: 3.491
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Cuocolo A, Nicolai E, Petretta M, Pace L, Cardei S, Varrone A, Trimarco B, Salvatore M
Effects of revascularization on survival and left ventricular function in patients with previous myocardial infarction and evidence of viable myocardium at thallium-201 imaging (246 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Cuocolo A, Petretta M, Nicolai E, Pace L, Acampa W, Varrone A, Bonaduce D, Salvatore M
Prognostic value of coronary angiography in patients with chronic ischemic left ventricular dysfunction and evidence of viable myocardium at thallium-201 reinjection imaging (315 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 May; 38(5SUPPL.): 387-395.
Impact Factor: 3.491
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Petretta M, Cuocolo A, Bonaduce D, Nicolai E, Cardei S, Berardino S, Ianniciello A, Apicella C, Bianchi V, Salvatore M
Incremental prognostic value of thallium reinjection after stress- redistribution imaging in patients with previous myocardial infarction and left ventricular dysfunction (332 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Feb; 38(2): 195-200.
Impact Factor: 3.491
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Marcassa C, Galli M, Cuocolo A, Scappellato F, Maurea S, Salvatore M
Rest-redistribution thallium-201 and rest technetium-99m-sestamibi SPECT in patients with stable coronary artery disease and ventricular dysfunction (291 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997; 38(3): 419-424.
Impact Factor: 3.491
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Tedeschi E, Soricelli A, Brunetti A, Romano M, Bucciero A, Iaconetta G, Alfieri A, Postiglione A, Salvatore M
Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas (379 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Nov; 23(11): 1478-1484.
Impact Factor: 2.692
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Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (852 views) (PDF 245 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
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Maurea S, Cuocolo A, Soricelli A, Castelli L, Nappi A, Trimarco B, Salvatore M
Technetium-99m MIBI SPECT to identify viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction (300 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1996; 92(3): 289-296.
Impact Factor: 0.967
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Klain M, Maurea S, Cuocolo A, Colao A, Marzano L, Lombardi G, Salvatore M
Technetium-99m tetrofosmin imaging in thyroid diseases: Comparison with Tc-99m-pertechnetate, thallium-201 and Tc-99m-methioxyisobutylisonitrile scans (307 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996; 23(12): 1568-1574.
Impact Factor: 2.692
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Maurea S, Cuocolo A, Soricelli A, Castelli L, Nappi A, Squame F, Imbriaco M, Trimarco B, Salvatore M
ENHANCED DETECTION OF VIABLE MYOCARDIUM BY TECHNETIUM-99M-MIBI IMAGING AFTER NITRATE ADMINISTRATION IN CHRONIC CORONARY-ARTERY DISEASE (245 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Nov; 36(11): 1945-1952.
Impact Factor: 3.491
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Maurea S, Cuocolo A, Soricelli A, Castelli L, Squame F, Imbriaco M, De Luca N, Trimarco B, Salvatore M
MYOCARDIAL VIABILITY INDEX IN CHRONIC CORONARY-ARTERY DISEASE - TECHNETIUM-99M-METHOXY ISOBUTYL ISONITRILE REDISTRIBUTION (256 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Nov; 36(11): 1953-1960.
Impact Factor: 3.491
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PACE L, CUOCOLO A, MARZULLO P, NICOLAI E, GIMELLI A, DELUCA N, RICCIARDELLI B, SALVATORE M
REVERSE REDISTRIBUTION IN RESTING TL-201 MYOCARDIAL SCINTIGRAPHY IN CHRONIC CORONARY-ARTERY DISEASE - AN INDEX OF MYOCARDIAL VIABILITY (210 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Nov; 36(11): N/D-N/D.
Impact Factor: 3.491
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Nicolai E, Cuocolo A, Pace L, Maurea S, Nappi A, Imbriaco M, Morisco C, Argenziano L, Salvatore M
Assessment of systolic wall thickening using technetium-99m methoxyisobutylisonitrile in patients with coronary artery disease: relation to thallium-201 scintigraphy with re-injection (322 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1995 Sep; 22(9): 1017-1022.
Impact Factor: 2.692
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Pace L, Cuocolo A, Nicolai E, Imbriaco M, Maurea S, Nappi A, Ricciardelli B, Salvatore M
REVERSE REDISTRIBUTION IN TL-201 STRESS-REDISTRIBUTION MYOCARDIAL SCINTIGRAPHY - EFFECT OF REST REINJECTION (271 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1994 Nov; 19(11): 956-961.
Impact Factor: 0.34
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Maurea S, Cuocolo A, Nicolai E, Salvatore M
Improved detection of viable myocardium with thallium-201 reinjection in chronic coronary artery disease: comparison with technetium-99m-MIBI imaging (292 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 Apr; 35(4): 621-624.
Impact Factor: 3.491
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Cuocolo A, Pace L, Maurea S, Ricciardelli B, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Enhanced thallium-201 uptake after reinjection: Relation to regional ventricular function, myocardial perfusion and coronary anatomy (247 views)
J Nucl Med Allied Sci, 1994 Mar; 38(1): 6-13.
Impact Factor: 0
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Left ventricular dysfunction in coronary artery disease: Comparison between rest-redistribution thallium 201 and resting technetium 99m methoxyisobutyl isonitrile cardiac imaging (302 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 1994 Jan; 1(1): 65-71.
Impact Factor: 1.878
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Cuocolo A, Maurea S, Pace L, Nicolai E, Nappi A, Imbriaco M, Trimarco B, Salvatore M
Resting technetium-99m methoxyisobutylisonitrile cardiac imaging in chronic coronary artery disease: comparison with rest-redistribution thallium-201 scintigraphy (323 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1993 Dec; 20(12): 1186-1192.
Impact Factor: 2.692
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Pace L, Cuocolo A, Maurea S, Nicolai E, Imbriaco M, Nappi A, Morisco C, Chiariello M, Trimarco B, Salvatore M
Reverse redistribution in resting thallium-201 myocardial scintigraphy in patients with coronary artery disease: Relation to coronary anatomy and ventricular function (310 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1993 Oct; 34(10): 1688-1692.
Impact Factor: 3.491
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PETRETTA M, BONADUCE D, CUOCOLO A, MORGANO G, NICOLAI E, PULCINO A, BIANCHI V, SALVATORE M
Incremental prognostic value of thallium imaging and coronary angiography in patients with a symptom-limited ECG stress test (394 views)
Coron Artery Dis (ISSN: 0954-6928), 1993 Jul; 4(7): 637-644.
Impact Factor: 0.653
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Maurea S, Cuocolo A, Pace L, Nicolai E, Nappi A, Imbriaco M, Morisco C, Chiariello M, Trimarco B, Salvatore M
Rest-injected thallium-201 redistribution and resting technetium-99m methoxyisobutylisonitrile uptake in coronary artery disease: relation to the severity of coronary artery stenosis (279 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1993 Jun; 20(6): 502-510.
Impact Factor: 2.692
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84 Records (80 excluding Abstracts).
Total impact factor: 231.598 (218.313 excluding Abstracts).
Total 5 year impact factor: 287.6 (267.624 excluding Abstracts).
Total impact factor: 231.598 (218.313 excluding Abstracts).
Total 5 year impact factor: 287.6 (267.624 excluding Abstracts).
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