Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging(479 views) Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
Affiliations: Department of Diagnostic Imaging, University of Naples Federico II, Largo Torraca 71, 80133 Naples, Italy
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Elligsen, J. D., Thompson, J. E., Frey, H. E., Kruvv, J., Correlation of (Na+-K+) ATPase activity with growth of normal and transformed cells (1974) Exp Cell Res, 87, pp. 233-240
Kasarov, L. B., Friedmann, H., Enhanced Na+-K+ activated adenosine triphosphatase activity in transformed fibroblasts (1974) Cancer Res, 34, pp. 1862-1865
Atkins, H. L., Budinger, T. F., Labowitz, E., Thallium-201 for medical use. Part 3: Human distribution and physical imaging properties (1977) J Nucl Med, 18, pp. 133-140
Black, K. L., Hawkins, R. A., Kim, K. T., Becker, D. P., Lerner, C., Marciano, D., Use of thallium-201 SPECT to quantitate malignancy grade of gliomas (1989) J Neurosurg, 71, pp. 342-346
Kelly, J. D., Forster, A. M., Higley, B., Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging (1993) J Nucl Med, 34, pp. 222-227
O'Tuama, L. A., Janicek, M., Barnes, P. D., Thallium-201/99mTc-HMPAO SPECT imaging of treated childhood brain tumors (1991) Pediatr Neurol, 11, pp. 249-257
Platts, E. A., North, T. L., Pickett, R. D., Kelly, J. D., Mechanism of uptake of technetium-tetrofosmin. I: Uptake into isolated adult rat ventricular myocytes and subcellular localization (1995) J Nucl Cardiol, 2, pp. 317-326
Youn s, A., Songadele, J. A., Maublant, J., Platts, E., Pickett, R., Veyre, A., Mechanism of uptake of technetium-tetrofosmin. II: Uptake into isolated adult rat heart mitochondria (1995) J Nucl Cardiol, 2, pp. 327-333
Arbab, A. S., Koizumi, K., Toyama, K., Arai, T., Araki, T., Uptake of 99mTc-tetrofosmin in a tumor cell line: Comparison with 99mTc-MIBI (1996) J Nucl Med, 37 (SUPPL.), pp. 254P
Moustafa, H. M., Omar, W. M., Ezzat, I., Ziada, G. A., El-Ghonimy, E. G., Thallium-201 single photon emission tomography in the evaluation of residual and recurrent astrocytoma (1994) Nucl Med Commun, 15, pp. 140-143
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging
Thallium-201 is clinically used for the assessment of primary and recurrent brain tumors. The biologic properties of Tl-201 that allow it to accumulate within the tumor cells render Tl-201 useful in evaluating tumor malignancy, but its physical characteristics and nonroutine availability limits its use in some institutions, as compared to Tc-99m-labeled compounds. The aim of this study was to assess the feasibility of using Tc-99m-tetrofosmin for imaging brain tumors and to compare its uptake with that of Tl-201. Methods: Twenty-six patients with 27 intracranial masses were studied with SPECT. In the first group of seven patients (Group A), the timing for optimal acquisition of the Tc-99m-tetrofosmin scan was assessed. In the second group of 19 patients (Group B), two sequential Tl-201 (74-148 MBq intravenous) and Tc-99m-tetrofosmin (740-925 MBq intravenous) studies were performed 20 min after tracer injection and compared. Results: In Group A, no significant difference in the tumor-to-background (T/B) ratio among the 20-, 40- and 120-min postinjection studies was observed. In Group B, the quality of reconstructed images with Tc-99m-tetrofosmin, judged visually, was superior to that of Tl-201 in 47% of all studies and was comparable in the remaining 53%. A significant relationship between Tl-201 and Tc-99m-tetrofosmin T/B ratio (r = 0.75, p < 0.01) was found. The T/B ratio of Tc-99m-tetrofosmin was significantly higher than that of Tl-201 (23.3 +/- 21.5 compared to 6.1 +/- 2.9, p < 0.005). Conclusion: Technetium-99m-tetrofosmin is a suitable radiotracer for the imaging of intracranial lesions with SPECT. Moreover, a better definition of tumor margins and a higher contrast between neoplastic and normal brain tissue can be achieved.
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging
No results.
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(730 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote