Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging(724 views) Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
Affiliations: Department of Diagnostic Imaging, University of Naples Federico II, Largo Torraca 71, 80133 Naples, Italy
References: Not available.
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging
Thallium-201 is clinically used for the assessment of primary and recurrent brain tumors. The biologic properties of Tl-201 that allow it to accumulate within the tumor cells render Tl-201 useful in evaluating tumor malignancy, but its physical characteristics and nonroutine availability limits its use in some institutions, as compared to Tc-99m-labeled compounds. The aim of this study was to assess the feasibility of using Tc-99m-tetrofosmin for imaging brain tumors and to compare its uptake with that of Tl-201. Methods: Twenty-six patients with 27 intracranial masses were studied with SPECT. In the first group of seven patients (Group A), the timing for optimal acquisition of the Tc-99m-tetrofosmin scan was assessed. In the second group of 19 patients (Group B), two sequential Tl-201 (74-148 MBq intravenous) and Tc-99m-tetrofosmin (740-925 MBq intravenous) studies were performed 20 min after tracer injection and compared. Results: In Group A, no significant difference in the tumor-to-background (T/B) ratio among the 20-, 40- and 120-min postinjection studies was observed. In Group B, the quality of reconstructed images with Tc-99m-tetrofosmin, judged visually, was superior to that of Tl-201 in 47% of all studies and was comparable in the remaining 53%. A significant relationship between Tl-201 and Tc-99m-tetrofosmin T/B ratio (r = 0.75, p < 0.01) was found. The T/B ratio of Tc-99m-tetrofosmin was significantly higher than that of Tl-201 (23.3 +/- 21.5 compared to 6.1 +/- 2.9, p < 0.005). Conclusion: Technetium-99m-tetrofosmin is a suitable radiotracer for the imaging of intracranial lesions with SPECT. Moreover, a better definition of tumor margins and a higher contrast between neoplastic and normal brain tissue can be achieved.
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging
No results.
Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(1028 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote