Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates(336 views) Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB
Affiliations: Tumor Biology Section, Radiation Biology Branch, National Institutes of Health, Bethesda, MD 20892, United States
Department of Physiology, Louisiana State Univ. Medical Center, Shreveport, LA 71130, United States
Department of Chemistry, Grambling State University, Grambling, LA 71245, United States
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Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates
Thiol-containing proteins are key to numerous cellular processes, and their functions can be modified by thiol nitrosation or oxidation. Nitrosation reactions are quenched by O-2(radical anion), while the oxidation chemistry mediated by peroxynitrite is quenched by excess flux of either NO or O-2(radical anion). A solution of glutathione (GSH), a model thiol containing tripeptide, exclusively yielded S-nitrosoglutathione when exposed to the NO donor, Et2NN(O)NONa. However, when xanthine oxidase was added to the same mixture, the yield of S-nitrosoglutathione dramatically decreased as the activity of xanthine oxidase increased, such that there was a 95% reduction in nitrosation when the fluxes of NO and O-2(radical anion) were nearly equivalent. The presence of superoxide dismutase reversed O-2(radical anion)-mediated inhibition, while catalase had no effect. Increasing the flux of O-2(radical anion) yielded oxidized glutathione (GSSG), peaking when the flux of NO and O-2(radical anion) were approximately equivalent. The results suggest that oxidation and nitrosation of thiols by superoxide and NO are determined by their relative fluxes and may have physiological significance.
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates
No results.
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(349 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote