Affiliations: Neuroscience Program, University of Western Ontario, London, Ont. N6G 2V4, Canada
Psychology Department, University of Western Ontario, London, Ont. N6G 2V4, Canada
Department of Psychology, Queen's University, Kingston, Ont. K7L 3N6, Canada
References: Azmitia, E.C., Segal, M., An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat (1978) J Comp Neurol, 179, pp. 641-66
Bindra, D., What makes rats hoard? (1948) J Comp Physiol Psychol, 41, pp. 397-402
Blanchard, D.C., Blanchard, R.J., Innate and conditioned reactions to threat in rats with amygdaloid lesions (1972) J Comp Psychol, 81, pp. 281-290
Bolhuis, J.J., Fitzgerald, R.E., Dijk, D.L., Koolhaas, J.M., The corticomedial amygdala and learning in an agonistic situation in the rat (1984) Physiol Behav, 32, pp. 575-579
Cain, D.P., Bindra, D., Responses of amygdala single units to odors in the rat (1972) Exp Neurol, 35, pp. 98-110
Carli, M., Prontera, C., Samanin, R., Evidence that central 5-hydroxytryptaminergic neurones are involved in the anxiolytic activity of buspirone (1989) Br J Pharmacol, 96, pp. 829-836
Clark, M., Fletcher, A., Does buspirone elicit feeding by a similar mechanism to that of 8-OH-DPAT? (1986) Br J Pharmacol, 89, p. 863
Crawley, J., Goodwin, F.K., Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines (1980) Pharmacol Biochem Behav, 13, pp. 167-170
Davies, M., The role of the amygdala in conditioned fear (1992) The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction, pp. 255-305. , In: Aggleton JP, editor. New York: Wiley-Liss
De Olmos, J., Alheid, G.F., Beltramino, C.A., Amygdala (1985) The Rat Nervous System, Vol. 1, Forebrain and Midbrain, pp. 223-334. , In: Paxinos G, editor. Sydney: Academic Press
Dringenberg, H.C., Kornelsen, R.A., Vanderwolf, C.H., Food carrying in rats is blocked by the putative anxiolytic agent buspirone (1994) Pharmacol Biochem Behav, 49, pp. 741-746
Eison, A.S., Eison, M.S., Stanley, M., Riblet, L.A., Serotonergic mechanisms in the behavioral effects of buspirone and gepirone (1986) Pharmacol Biochem Behav, 24, pp. 701-707
Eison, A.S., Temple, D.L., Buspirone: Review of its pharmacology and current perspectives on the mechanism of action (1989) Am J Med, 80 (SUPPL. 3B), pp. 1-9
Fanselow, M.S., The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety (1991) The Midbrain Periaqueductal Grey Matter: Functional, Anatomical and Immunohistochemical Organization, pp. 151-173. , In: Depaulis A, Bandler R, editors. New York: Plenum Publishing Organization
Fantino, M., Cabanac, M., Body weight regulation with a proportional hoarding response in the rat (1980) Physiol Behav, 24, pp. 939-942
Fernandez-Guasti, A., Lopez-Rubalcava, C., Perez-Urizar, J., Castaneda-Hernandez, G., Evidence for a postsynaptic action of the serotonergic anxiolytics: Ipsapirone, indorenate and buspirone (1992) Brain Res Bull, 28, pp. 497-501
Gargiulo, P.A., Viana, M.B., Graeff, F.G., De Souza Silva, M.A., Tomaz, C., Effects on anxiety and memory of systemic and intra-amygdala injections of 5-HT 3 receptor antagonist BRL 46470A (1996) Neuropsychobiology, 33, pp. 189-195
Geller, I., Hartmann, R.J., Effects of buspirone on operant behavior of laboratory rats and cynomolgus monkeys (1982) J Clin Psychiatry, 43, pp. 25-32
Glaser, T., Traber, J., Buspirone: Action on serotonin receptors in calf hippocampus (1983) Eur J Pharmacol, 88, pp. 137-138
Gloor, P., Amygdala (1960) Handbook of Physiology, Section 1: Neurophysiology, 2, pp. 1395-1420. , In: Field J, Magoun HW, Hall VE, editors. Washington: American Physiological Society
Goldberg, A.L., Finnerty, R.J., The comparative efficacy of buspirone and diazepam in the treatment of anxiety (1979) Am J Psychiatry, 136, pp. 1184-1187
Gray, J.A., (1982) The Neuropsychology of Anxiety, , New York: Oxford University Press
Halgren, E., Emotional neurophysiology of the amygdala within the context of human cognition (1992) The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction, pp. 191-228. , In: Aggleton JP, editor. New York: Wiley-Liss
Hall, M.D., El Mestikawy, S., Emerit, M.B., Pichat, L., Hamon, M., Gozlan, H., [ 3H]8-hydroxy-2-(di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain (1985) J Neurochem, 44, pp. 1685-1696
Horel, J.A., Some comments on the special cognitive functions claimed for the hippocampus (1994) Cortex, 30, pp. 269-280
Horel, J.A., Keating, E.G., Misantone, L.J., Partial Klüver-Bucy syndrome produced by destroying temporal neocortex or amygdala (1975) Brain Res, 94, pp. 347-359
Kimble, D.P., The effects of bilateral hippocampal lesions in rats (1963) J Comp Physiol Psychol, 56, pp. 273-283
LeDoux, J.E., Emotion and the amygdala (1992) The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction, pp. 339-351. , In: Aggleton JP, editor. New York: Wiley-Liss
Lima, S.L., Maximizing feeding efficiency and minimizing time exposed to predators: A trade-off in the black-capped chickadee (1985) Oecologia (Berlin), 66, pp. 60-67
Lima, S.L., Valone, T.J., Caraco, T., Foraging-efficiency-risk trade-off in the grey squirrel (1985) Anim Behav, 33, pp. 155-165
Luiten, P.G.M., Koolhaas, J.M., DeBoer, S., Koopmans, S.J., The corticomedial amygdala in the central nervous system organization of agonistic behavior (1985) Brain Res, 332, pp. 283-297
MacLean, P.D., The limbic system ('visceral brain') and emotional behavior (1955) Arch Neurol Psychiatry, 73, pp. 130-134
Mansbach, R.S., Geyer, M.A., Blockade of potentiated startle responding in rats by 5-hydroxytryptamine 1A receptor ligands (1988) Eur J Pharmacol, 156, pp. 375-383
Martin, J.R., Moreau, J.-L., Jenck, F., Cumin, R., Acute and chronic administration of buspirone fails to yield anxiolytic-like effects in a mouse operant punishment paradigm (1993) Pharmacol Biochem Behav, 46, pp. 905-910
McCleary, R.A., Morgan, C.T., Food hoarding in rats as a function of environmental temperature (1946) J Comp Psychol, 39, pp. 371-378
McNamara, R.K., Whishaw, I.Q., Blockade of hoarding in rats by diazepam: An analysis of the anxiety and object value hypotheses of hoarding (1990) Psychopharmacology, 101, pp. 214-221
Merlo Pich, E., Samanin, R., Disinhibitory effects of buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats: Possible role of dopamine (1986) Psychopharmacology, 89, pp. 125-130
Miller, G.A., Viek, P., An analysis of the rat's response to unfamiliar aspects of the hoarding situation (1944) J Comp Psychol, 37, pp. 221-231
Nagy, J., Zambo, K., Decsi, L., Anti-anxiety action of diazepam after intra-amygdaloid application in the rat (1979) Neuropharmacology, 18, pp. 573-576
Oddie, S.D., Kirk, I.J., Whishaw, I.Q., Bland, B.H., The hippocampal formation is involved in movement selection: Evidence from medial septal cholinergic modulation and concurrent slow-wave (theta rhythm) recording (1997) Behav Brain Res, 88, pp. 169-180
Oddie, S.D., Stefanek, W., Kirk, I.J., Bland, B.H., Intraseptal procaine abolishes hypothalamic stimulation-induced wheel-running and hippocampal theta field activity in rats (1996) J Neurosci, 16, pp. 1948-1956
Palacios, J.M., Waeber, C., Hoyer, D., Mengod, G., Distribution of serotonin receptors (1990) Ann New York Acad Sci, 600, pp. 36-52
Papez, J.W., A proposed mechanism of emotion (1937) Arch Neurol Psychiatry, 38, pp. 725-744
Pazos, A., Palacios, J.M., Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors (1985) Brain Res, 346, pp. 205-230
Peroutka, S.J., Selective interaction of novel anxiolytics with 5-hydroxytryptamine 1A receptors (1985) Biol Psychiatry, 20, pp. 971-979
Pollard, G.T., Howard, J.L., Cork gnawing in the rat as a screening method for buspirone-like anxiolytics (1991) Drug Dev Res, 22, pp. 179-187
Pompeiano, M., Palacios, J.S., Mengod, G., Distribution of cellular localization of mRNA coding for 5-HT 1A receptor in the rat brain: Correlation with receptor binding (1992) J Neurosci, 12, pp. 440-453
Roberts, W.W., Dember, W.N., Brodwick, M., Alternation and exploration in rats with hippocampal lesions (1962) J Comp Physiol Psychol, 55, pp. 695-700
Sanchez, C., 5-HT 1A receptors play an important role in modulation of behavior of rats in a two-compartment black and white box (1996) Behav Pharmacol, 7, pp. 788-797
Schacter, G.B., Phelps, M.T., Brobeck, D.R., Mogenson, G.J., Roberts, W.A., Disruption of central-place foraging in the rat following lesions of the dorsomedial thalamic nucleus (1991) Psychobiology, 19, pp. 91-99
Stamm, J.S., Control of hoarding activity in rats by the median cerebral cortex (1954) J Comp Physiol Psychol, 47, pp. 21-27
Steinbusch, H.W.M., Nieuwenhuys, R., The raphe nuclei of the rat brainstem: A cytoarchitectonic and immunohistochemical study (1983) Chemical Neuroanatomy, pp. 131-207. , In: Emson PC, editor. New York: Raven Press
Taylor, D.P., Serotonin agents in anxiety (1990) Ann New York Acad Sci, 600, pp. 545-557
Teitelbaum, H., Milner, P., Activity changes following partial hippocampal lesions in rats (1963) J Comp Physiol Psychol, 56, pp. 284-289
Törk, I., Anatomy of the serotonergic system (1990) Ann New York Acad Sci, 600, pp. 366-383
Treit, D., Pesold, C., Rotzinger, S., Dissociating the anti-fear effects of septal and amygdaloid lesions using two pharmacologically validated models of rat anxiety (1993) Behav Neurosci, 107, pp. 770-785
Ursin, H., The effect of amygdaloid lesions on flight and defense behavior in cats (1965) Exp Neurol, 11, pp. 61-79
Ursin, H., Kaada, B.R., Functional localization within the amygdaloid complex in the cat (1960) Electroenceph Clin Neurophysiol, 12, pp. 1-20
VanderMaelen, C.P., Matheson, G.K., Wilderman, R.C., Patterson, L.A., Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug (1986) Eur J Pharmacol, 129, pp. 123-130
Vanderwolf, C.H., Neocortical and hippocampal activation in relation to behavior: Effects of atropine, phenothiazines, and amphetamine (1975) J Comp Physiol Psychol, 88, pp. 300-323
Vanderwolf, C.H., Brain, behavior, and mind: What do we know and what can we know? Neurosci Biobehav Rev, , (in press)
Vanderwolf, C.H., Kelley, M.E., Kraemer, P., Streather, A., Are emotion and motivation localized in the limbic system and nucleus accumbens? (1988) Behav Brain Res, 27, pp. 45-58
Wallace, R.J., Tinger, J.C., Effects of cortical and hippocampal lesions on hoarding behavior in the albino rat (1972) Physiol Behav, 8, pp. 937-942
Wheatley, D., Buspirone: Multicenter efficacy study (1982) J Clin Psychiatry, 43, pp. 92-94
Whishaw, I.Q., Hippocampal electroencephalographic activity in the mongolian gerbil during natural behaviours and wheel running and in the rat during wheel running and conditioned immobility (1972) Can J Psychol, 26, pp. 219-239
Whishaw, I.Q., A simple behavioral paradigm for the study of Type I hippocampal rhythmical slow activity (RSA) frequency shifts (1982) Physiol Behav, 29, pp. 751-753
Whishaw, I.Q., Time estimates contribute to food handling decisions by rats: Implications for neural control of hoarding (1990) Psychobiology, 18, pp. 460-466
Whishaw, I.Q., Activation, travel distance, and environmental change influence food carrying in rats with hippocampal, medial thalamic and septal lesions: Implications for studies on hoarding and theories of hippocampal function (1993) Hippocampus, 3, pp. 373-385
Whishaw, I.Q., Dringenberg, H.C., How dies the rat (Rattus norvegicus) adjust food-carrying responses to the influence of distance, effort, predatory odor, food size, and food availability? (1991) Psychobiology, 19, pp. 251-261
Whishaw, I.Q., Gorney, B.P., Dringenberg, H.C., The defensive strategies of foraging rats: A review and synthesis (1991) Psychol Rec, 41, pp. 185-205
Whishaw, I.Q., Oddie, S.D., McNamara, R.K., Harris, T.L., Perry, B.S., Psychophysical methods for study of sensory-motor behavior using a food-carry (Hoarding) task in rodents (1990) J Neurosci Methods, 32, pp. 123-133
Whishaw, I.Q., Tomie, J., Food-pellet size modifies the hoarding behavior of foraging rats (1989) Psychobiology, 17, pp. 93-101
Whishaw, I.Q., Whishaw, G.E., Conspecific aggression influences food carrying: Studies on a wild population of Rattus norvegicus (1996) Aggressive Behav, 22, pp. 47-66
Wilkinson, L.O., Auerbach, S.B., Jacobs, B.L., Extracellular serotonin levels change with behavioral state but not with pyrogen-induced hyperthermia (1991) J Neurosci, 11, pp. 2732-2741
Wilkinson, L.O., Dourish, C.T., Serotonin and animal behavior (1991) Serotonin Receptor Subtypes: Basic and Clinical Aspects, pp. 147-210. , In: Peroutka SJ, editor. New York: Wiley-Liss
Wishart, T., Brohman, L., Mogenson, G., Effects of lesions of the hippocampus and septum on hoarding behavior (1969) Anim Behav, 17, pp. 781-784
Azmitia, E. C., Segal, M., An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat (1978) J Comp Neurol, 179, pp. 641-66
Blanchard, D. C., Blanchard, R. J., Innate and conditioned reactions to threat in rats with amygdaloid lesions (1972) J Comp Psychol, 81, pp. 281-290
Bolhuis, J. J., Fitzgerald, R. E., Dijk, D. L., Koolhaas, J. M., The corticomedial amygdala and learning in an agonistic situation in the rat (1984) Physiol Behav, 32, pp. 575-579
Cain, D. P., Bindra, D., Responses of amygdala single units to odors in the rat (1972) Exp Neurol, 35, pp. 98-110
Dringenberg, H. C., Kornelsen, R. A., Vanderwolf, C. H., Food carrying in rats is blocked by the putative anxiolytic agent buspirone (1994) Pharmacol Biochem Behav, 49, pp. 741-746
Eison, A. S., Eison, M. S., Stanley, M., Riblet, L. A., Serotonergic mechanisms in the behavioral effects of buspirone and gepirone (1986) Pharmacol Biochem Behav, 24, pp. 701-707
Eison, A. S., Temple, D. L., Buspirone: Review of its pharmacology and current perspectives on the mechanism of action (1989) Am J Med, 80 (SUPPL. 3B), pp. 1-9
Fanselow, M. S., The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety (1991) The Midbrain Periaqueductal Grey Matter: Functional, Anatomical and Immunohistochemical Organization, pp. 151-173. , In: Depaulis A, Bandler R, editors. New York: Plenum Publishing Organization
Gargiulo, P. A., Viana, M. B., Graeff, F. G., De Souza Silva, M. A., Tomaz, C., Effects on anxiety and memory of systemic and intra-amygdala injections of 5-HT 3 receptor antagonist BRL 46470A (1996) Neuropsychobiology, 33, pp. 189-195
Goldberg, A. L., Finnerty, R. J., The comparative efficacy of buspirone and diazepam in the treatment of anxiety (1979) Am J Psychiatry, 136, pp. 1184-1187
Gray, J. A., (1982) The Neuropsychology of Anxiety, , New York: Oxford University Press
Hall, M. D., El Mestikawy, S., Emerit, M. B., Pichat, L., Hamon, M., Gozlan, H., [3H] 8-hydroxy-2- (di-n-propylamino) tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain (1985) J Neurochem, 44, pp. 1685-1696
Horel, J. A., Some comments on the special cognitive functions claimed for the hippocampus (1994) Cortex, 30, pp. 269-280
Horel, J. A., Keating, E. G., Misantone, L. J., Partial Kl ver-Bucy syndrome produced by destroying temporal neocortex or amygdala (1975) Brain Res, 94, pp. 347-359
Kimble, D. P., The effects of bilateral hippocampal lesions in rats (1963) J Comp Physiol Psychol, 56, pp. 273-283
LeDoux, J. E., Emotion and the amygdala (1992) The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction, pp. 339-351. , In: Aggleton JP, editor. New York: Wiley-Liss
Lima, S. L., Maximizing feeding efficiency and minimizing time exposed to predators: A trade-off in the black-capped chickadee (1985) Oecologia (Berlin), 66, pp. 60-67
Lima, S. L., Valone, T. J., Caraco, T., Foraging-efficiency-risk trade-off in the grey squirrel (1985) Anim Behav, 33, pp. 155-165
Luiten, P. G. M., Koolhaas, J. M., DeBoer, S., Koopmans, S. J., The corticomedial amygdala in the central nervous system organization of agonistic behavior (1985) Brain Res, 332, pp. 283-297
MacLean, P. D., The limbic system ('visceral brain') and emotional behavior (1955) Arch Neurol Psychiatry, 73, pp. 130-134
Mansbach, R. S., Geyer, M. A., Blockade of potentiated startle responding in rats by 5-hydroxytryptamine 1A receptor ligands (1988) Eur J Pharmacol, 156, pp. 375-383
Martin, J. R., Moreau, J. -L., Jenck, F., Cumin, R., Acute and chronic administration of buspirone fails to yield anxiolytic-like effects in a mouse operant punishment paradigm (1993) Pharmacol Biochem Behav, 46, pp. 905-910
McCleary, R. A., Morgan, C. T., Food hoarding in rats as a function of environmental temperature (1946) J Comp Psychol, 39, pp. 371-378
McNamara, R. K., Whishaw, I. Q., Blockade of hoarding in rats by diazepam: An analysis of the anxiety and object value hypotheses of hoarding (1990) Psychopharmacology, 101, pp. 214-221
Miller, G. A., Viek, P., An analysis of the rat's response to unfamiliar aspects of the hoarding situation (1944) J Comp Psychol, 37, pp. 221-231
Oddie, S. D., Kirk, I. J., Whishaw, I. Q., Bland, B. H., The hippocampal formation is involved in movement selection: Evidence from medial septal cholinergic modulation and concurrent slow-wave (theta rhythm) recording (1997) Behav Brain Res, 88, pp. 169-180
Oddie, S. D., Stefanek, W., Kirk, I. J., Bland, B. H., Intraseptal procaine abolishes hypothalamic stimulation-induced wheel-running and hippocampal theta field activity in rats (1996) J Neurosci, 16, pp. 1948-1956
Palacios, J. M., Waeber, C., Hoyer, D., Mengod, G., Distribution of serotonin receptors (1990) Ann New York Acad Sci, 600, pp. 36-52
Papez, J. W., A proposed mechanism of emotion (1937) Arch Neurol Psychiatry, 38, pp. 725-744
Peroutka, S. J., Selective interaction of novel anxiolytics with 5-hydroxytryptamine 1A receptors (1985) Biol Psychiatry, 20, pp. 971-979
Pollard, G. T., Howard, J. L., Cork gnawing in the rat as a screening method for buspirone-like anxiolytics (1991) Drug Dev Res, 22, pp. 179-187
Roberts, W. W., Dember, W. N., Brodwick, M., Alternation and exploration in rats with hippocampal lesions (1962) J Comp Physiol Psychol, 55, pp. 695-700
Schacter, G. B., Phelps, M. T., Brobeck, D. R., Mogenson, G. J., Roberts, W. A., Disruption of central-place foraging in the rat following lesions of the dorsomedial thalamic nucleus (1991) Psychobiology, 19, pp. 91-99
Stamm, J. S., Control of hoarding activity in rats by the median cerebral cortex (1954) J Comp Physiol Psychol, 47, pp. 21-27
Steinbusch, H. W. M., Nieuwenhuys, R., The raphe nuclei of the rat brainstem: A cytoarchitectonic and immunohistochemical study (1983) Chemical Neuroanatomy, pp. 131-207. , In: Emson PC, editor. New York: Raven Press
Taylor, D. P., Serotonin agents in anxiety (1990) Ann New York Acad Sci, 600, pp. 545-557
T rk, I., Anatomy of the serotonergic system (1990) Ann New York Acad Sci, 600, pp. 366-383
VanderMaelen, C. P., Matheson, G. K., Wilderman, R. C., Patterson, L. A., Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug (1986) Eur J Pharmacol, 129, pp. 123-130
Vanderwolf, C. H., Neocortical and hippocampal activation in relation to behavior: Effects of atropine, phenothiazines, and amphetamine (1975) J Comp Physiol Psychol, 88, pp. 300-323
Wallace, R. J., Tinger, J. C., Effects of cortical and hippocampal lesions on hoarding behavior in the albino rat (1972) Physiol Behav, 8, pp. 937-942
Whishaw, I. Q., Hippocampal electroencephalographic activity in the mongolian gerbil during natural behaviours and wheel running and in the rat during wheel running and conditioned immobility (1972) Can J Psychol, 26, pp. 219-239
Whishaw, I. Q., A simple behavioral paradigm for the study of Type I hippocampal rhythmical slow activity (RSA) frequency shifts (1982) Physiol Behav, 29, pp. 751-753
Whishaw, I. Q., Time estimates contribute to food handling decisions by rats: Implications for neural control of hoarding (1990) Psychobiology, 18, pp. 460-466
Whishaw, I. Q., Activation, travel distance, and environmental change influence food carrying in rats with hippocampal, medial thalamic and septal lesions: Implications for studies on hoarding and theories of hippocampal function (1993) Hippocampus, 3, pp. 373-385
Whishaw, I. Q., Dringenberg, H. C., How dies the rat (Rattus norvegicus) adjust food-carrying responses to the influence of distance, effort, predatory odor, food size, and food availability? (1991) Psychobiology, 19, pp. 251-261
Whishaw, I. Q., Gorney, B. P., Dringenberg, H. C., The defensive strategies of foraging rats: A review and synthesis (1991) Psychol Rec, 41, pp. 185-205
Whishaw, I. Q., Oddie, S. D., McNamara, R. K., Harris, T. L., Perry, B. S., Psychophysical methods for study of sensory-motor behavior using a food-carry (Hoarding) task in rodents (1990) J Neurosci Methods, 32, pp. 123-133
Whishaw, I. Q., Tomie, J., Food-pellet size modifies the hoarding behavior of foraging rats (1989) Psychobiology, 17, pp. 93-101
Whishaw, I. Q., Whishaw, G. E., Conspecific aggression influences food carrying: Studies on a wild population of Rattus norvegicus (1996) Aggressive Behav, 22, pp. 47-66
Wilkinson, L. O., Auerbach, S. B., Jacobs, B. L., Extracellular serotonin levels change with behavioral state but not with pyrogen-induced hyperthermia (1991) J Neurosci, 11, pp. 2732-2741
Wilkinson, L. O., Dourish, C. T., Serotonin and animal behavior (1991) Serotonin Receptor Subtypes: Basic and Clinical Aspects, pp. 147-210. , In: Peroutka SJ, editor. New York: Wiley-Liss
Effects of amygdaloid lesions, hippocampal lesions, and buspirone on black-white exploration and food carrying in rats
Unlesioned rats exploring a black-white two compartment box spent most of the time in the covered, black half of the box and only little time in the uncovered, white half (67 s/5 min). Large radio-frequency lesions of the amygdala or hippocampus did not alter this pattern of exploration, but rats with hippocampus lesions were more active than the other two groups of rats. Treatment with the 5-HT(1A) receptor agonist buspirone (0.1 mg/kg, s.c.) increased the time thai unlesioned rats spent in the uncovered compartment (103 s), an effect that was less pronounced in hippocampus-lesioned rats and completely abolished by amygdala lesions. In a food transport test, unlesioned rats that traveled from a home cage to an exposed food source consumed small and medium-sized pellets immediately at the food source. Larger pellets, however, were carried back to the home cage for consumption. Rats with amygdala lesions ate fewer pellets at the food source and tended to carry more pellets back to the home cage for consumption than unlesioned rats. Rats with hippocampus lesions carried fewer pellets back to the home cage and ate more pellets at the food source. Buspirone (0.5-1.5 mg/kg, s.c.) reduced the carrying of large food items to the home cage and increased consumption of these pellets at the food source in all groups of rats. These results suggest that neither the amygdala nor the hippocampus play an important role in controlling exploratory behavior in a black-white compartment box, but that the amygdala may have some role in mediating the effect of buspirone to increase exploration of the white/open compartment. Further, the amygdala and hippocampus have opposing influences on the transport of food items to a shelter, the amygdala suppressing food carrying, and the hippocampus enhancing it. Neither structure is essential for the effect of buspirone to reduce food carrying. The hypothesis that limbic structures mediate 'fear/anxiety' responses is discussed critically.
Effects of amygdaloid lesions, hippocampal lesions, and buspirone on black-white exploration and food carrying in rats
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(284 views) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 ViewExport to BibTeXExport to EndNote