Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 6.44, 5-year impact factor: 6.371
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34548684785&partnerID=40&md5=d4442914736b686920d5711f307db2df
Keywords: Atm, Dna Damage, H4(d10s170), Ret Ptc1, Thyroid, Alanine, Atm Protein, Etoposide, Histone H3, Threonine, Apoptosis, Article, Carcinogenesis, Cell Survival, Clonogenic Assay, Controlled Study, Cytoplasm, Dna Synthesis, Enzyme Inhibition, Gene Silencing, Genotoxicity, Human, Human Cell, Ionizing Radiation, Lymphoblast, Mitosis, Priority Journal, Protein Function, Protein Localization, Protein Phosphorylation, Signal Transduction, Thyroid Tumor, Amino Acid Sequence, Cell Cycle Proteins, Cell Line, Cytoskeletal Proteins, Dna-Binding Proteins, Hela Cells, Molecular Sequence Data, Protein-Serine-Threonine Kinases, Thyroid Neoplasms, Tumor Suppressor Proteins, Mammalia, H4 (d10s170), Airway Obstruction, Brain Damage, Chronic Obstructive Lung Disease, Cognition, Cognitive Defect, Disease Severity, Drawing, Exercise, Hypoxemia, Letter, Major Clinical Study, Prognosis, Risk Assessment, Task Performance,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy
CNR Istituto di Biostrutture e Bioimmagini, Naples, Italy
Dipartimento di Medicina Sperimentale e Clinica, Università 'Magna Graecia', Catanzaro, Italy
Istituto di Endocrinologia Ed Oncologia Sperimentale del CNR, Naples, Italy
University Campus Bio-Medico, Rome, Italy
Italian National Research Center on Aging, Cosenza, Italy
Federico II University School of Medicine, Naples, Italy
Viale della Resistenza Pal. Alfa Scala H, I-87036 Rende (CS), Italy
References:
Bakkenist, C.J., Kastan, M.B., DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003) Nature, 421, pp. 499-50
Canman, C.E., Lim, D.S., The role of ATM in DNA damage responses and cancer (1998) Oncogene, 17, pp. 3301-3308
Caudill, C.M., Zhu, Z., Ciampi, R., Stringer, J.R., Nikiforov, Y.E., Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: A model of carcinogenic chromosomal rearrangement induced by ionizing radiation (2005) J Clin Endocrinol Metab, 90, pp. 2364-2369
Celetti, A., Cerrato, A., Merolla, F., Vitagliano, D., Vecchio, G., Grieco, M., H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: Functional characterization (2004) Oncogene, 23, pp. 109-121
DiTullio Jr, R.A., Mochan, T.A., Venere, M., Bartkova, J., Sehested, M., Bartek, J., 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human (2002) Nat Cell Biol cancer, 4, pp. 998-1002
Fusco, A., Grieco, M., Santoro, M., Berlingieri, M.T., Pilotti, S., Pierotti, M.A., A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases (1987) Nature, 328, pp. 170-172
Goodhead, D.T., Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA (1994) Int J Radiat Biol, 65, pp. 7-17
Grieco, M., Cerrato, A., Santoro, M., Fusco, A., Melillo, R.M., Vecchio, G., Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo (1994) Oncogene, 9, pp. 2531-2535
Hickson, I., Zhao, Y., Richardson, C.J., Green, S.J., Martin, N.M., Orr, A.I., Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM (2004) Cancer Res, 64, pp. 9152-9159
Iliakis, G., Wang, Y., Guan, J., Wang, H., DNA damage checkpoint control in cells exposed to ionizing radiation (2003) Oncogene, 22, pp. 5834-5847
Jhiang, S.M., The RET proto-oncogene in human cancers (2000) Oncogene, 19, pp. 5590-5597
Jossart, G.H., O'Brien, B., Cheng, J.F., Tong, Q., Jhiang, S.M., Duh, Q., A novel multicolor hybridization scheme applied to localization of a transcribed sequence (D10S170/H4) and deletion mapping in the thyroid cancer cell line TPC-1 (1996) Cytogenet Cell Gene, 75, pp. 254-257
Kastan, M., Lim, D.S., The many substrates and functions of ATM (2000) Nat Rev Mol Cell Biol, 1, pp. 179-186
Kim, S.T., Lim, D.S., Canman, C.E., Kastan, M.B., Substrate specificities and identification of putative substrates of ATM kinase family members (1999) J Biol Chem, 274, pp. 37538-37543
Kulkarni, S., Heath, C., Parker, S., Chase, A., Iqbal, S., Pocock, C.F., Fusion of H4/D10S170 to the platelet-derived growth factor receptor beta in BCR-ABL-negative myeloproliferative disorders with a t(5
q21) (2000) Cancer Res, 60, pp. 3592-3598
Laemli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
Lee, J.H., Paull, T.T., Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex (2004) Science, 304, pp. 93-96
Leskov, K.S., Criswell, T., Antonio, S., Li, J., Yang, C.R., Kinsella, T.J., When X-ray-inducible proteins meet DNA double strand break repair (2001) Semin Radiat Oncol, 11, pp. 352-372
Lim, D.S., Kim, S.T., Xu, B., Maser, R.S., Lin, J., Petrini, J.H., ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway (2000) Nature, 404, pp. 613-617
Little, J.B., Genomic instability and bystander effects: A historical perspective (2003) Oncogene, 22, pp. 6978-6987
Motoyama, N., Naka, K., DNA damage tumor suppressor genes and genomic instability (2004) Curr Opin Genet Dev, 14, pp. 11-16
Nikiforova, M.N., Ciampi, R., Salvatore, G., Santoro, M., Gandhi, M., Knauf, J.A., Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas (2004) Cancer Lett, 209, pp. 1-6
Nikiforova, M.N., Stringer, J.R., Blough, R., Medvedovic, M., Fagin, J.A., Nikiforov, Y.E., Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells (2000) Science, 290, pp. 138-141
Obenauer, J.C., Cantley, L.C., Yaffe, M.B., Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs (2003) Nucleic Acids Res, 31, pp. 3635-3641
O'Neill, T., Dwyer, A.J., Ziv, Y., Chan, D.W., Lees-Miller, S.P., Abraham, R.H., Utilization of oriented peptide libraries to identify substrate motifs selected by ATM (2000) J Biol Chem, 275, pp. 22719-22727
Penserga, E.T., Skorski, T., Fusion tyrosine kinases: A result and cause of genomic instability (2007) Oncogene, 26, pp. 11-20
Pierotti, M.A., Santoro, M., Jenkins, R.B., Sozzi, G., Bongarzone, I., Grieco, M., Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC (1992) Proc Natl Acad Sci USA, 89, pp. 1616-1620
Puxeddu, E., Zhao, G., Stringer, J.R., Medvedovic, M., Moretti, S., Fagin, J.A., Characterization of novel non-clonal intrachromosomal rearrangements between the H4 and PTEN genes (H4/PTEN) in human thyroid cell lines and papillary thyroid cancer specimens (2005) Mutat Res, 570, pp. 17-32
Radivoyevitch, T., Sachs, R.K., Nikiforov, Y.E., Nikiforova, M.N., Little, M.P., On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer (2001) Radiat Environ Biophys, 40, pp. 191-197
Ron, E., Lubin, J.H., Shore, R.E., Mabuchi, K., Modan, B., Pottern, L.M., On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer (1995) Radiat Res, 141, pp. 259-277
Schwaller, J., Anastasiadou, E., Cain, D., Kutok, J., Wojiski, S., Williams, I.R., H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5
q22) (2001) Blood, 97, pp. 3910-3918
Sheils, O.M., O'Leary, J.J., Sweeney, E.C., Assessment of ret/PTC-1 rearrangements in neoplastic thyroid tissue using TaqMan RT-PCR (2000) J Pathol, 192, pp. 32-36
Shiloh, Y., ATM: Ready, set, go (2003) Cell Cycle, 2, pp. 116-117
Smith, L.E., Nagar, S., Kim, G.J., Morgan, W.F., Radiation-induced genomic instability: Radiation quality and dose response (2003) Health Phys, 85, pp. 23-29
Tong, Q., Xing, S., Jhiang, S.M., Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity (1997) J Biol Chem, 272, pp. 9043-9047
Towbin, H., Staehelin, T., Gordon, J., Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications (1979) Proc Natl Acad Sci USA, 76, pp. 4350-4354
Ward, J.F., Radiation mutagenesis: The initial DNA lesions responsible (1995) Radiat Res, 142, pp. 362-368
Bakkenist, C. J., Kastan, M. B., DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003) Nature, 421, pp. 499-50
Canman, C. E., Lim, D. S., The role of ATM in DNA damage responses and cancer (1998) Oncogene, 17, pp. 3301-3308
Caudill, C. M., Zhu, Z., Ciampi, R., Stringer, J. R., Nikiforov, Y. E., Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: A model of carcinogenic chromosomal rearrangement induced by ionizing radiation (2005) J Clin Endocrinol Metab, 90, pp. 2364-2369
DiTullio Jr, R. A., Mochan, T. A., Venere, M., Bartkova, J., Sehested, M., Bartek, J., 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human (2002) Nat Cell Biol cancer, 4, pp. 998-1002
Goodhead, D. T., Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA (1994) Int J Radiat Biol, 65, pp. 7-17
Jhiang, S. M., The RET proto-oncogene in human cancers (2000) Oncogene, 19, pp. 5590-5597
Jossart, G. H., O'Brien, B., Cheng, J. F., Tong, Q., Jhiang, S. M., Duh, Q., A novel multicolor hybridization scheme applied to localization of a transcribed sequence (D10S170/H4) and deletion mapping in the thyroid cancer cell line TPC-1 (1996) Cytogenet Cell Gene, 75, pp. 254-257
Kim, S. T., Lim, D. S., Canman, C. E., Kastan, M. B., Substrate specificities and identification of putative substrates of ATM kinase family members (1999) J Biol Chem, 274, pp. 37538-37543
Laemli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
Lee, J. H., Paull, T. T., Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex (2004) Science, 304, pp. 93-96
Leskov, K. S., Criswell, T., Antonio, S., Li, J., Yang, C. R., Kinsella, T. J., When X-ray-inducible proteins meet DNA double strand break repair (2001) Semin Radiat Oncol, 11, pp. 352-372
Lim, D. S., Kim, S. T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H., ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway (2000) Nature, 404, pp. 613-617
Little, J. B., Genomic instability and bystander effects: A historical perspective (2003) Oncogene, 22, pp. 6978-6987
Nikiforova, M. N., Ciampi, R., Salvatore, G., Santoro, M., Gandhi, M., Knauf, J. A., Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas (2004) Cancer Lett, 209, pp. 1-6
Obenauer, J. C., Cantley, L. C., Yaffe, M. B., Scansite 2. 0: Proteome-wide prediction of cell signaling interactions using short sequence motifs (2003) Nucleic Acids Res, 31, pp. 3635-3641
Penserga, E. T., Skorski, T., Fusion tyrosine kinases: A result and cause of genomic instability (2007) Oncogene, 26, pp. 11-20
Pierotti, M. A., Santoro, M., Jenkins, R. B., Sozzi, G., Bongarzone, I., Grieco, M., Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC (1992) Proc Natl Acad Sci USA, 89, pp. 1616-1620
Ron, E., Lubin, J. H., Shore, R. E., Mabuchi, K., Modan, B., Pottern, L. M., On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer (1995) Radiat Res, 141, pp. 259-277
Sheils, O. M., O'Leary, J. J., Sweeney, E. C., Assessment of ret/PTC-1 rearrangements in neoplastic thyroid tissue using TaqMan RT-PCR (2000) J Pathol, 192, pp. 32-36
Smith, L. E., Nagar, S., Kim, G. J., Morgan, W. F., Radiation-induced genomic instability: Radiation quality and dose response (2003) Health Phys, 85, pp. 23-29
Ward, J. F., Radiation mutagenesis: The initial DNA lesions responsible (1995) Radiat Res, 142, pp. 362-368
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 6.44, 5-year impact factor: 6.371
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34548684785&partnerID=40&md5=d4442914736b686920d5711f307db2df
Keywords: Atm, Dna Damage, H4(d10s170), Ret Ptc1, Thyroid, Alanine, Atm Protein, Etoposide, Histone H3, Threonine, Apoptosis, Article, Carcinogenesis, Cell Survival, Clonogenic Assay, Controlled Study, Cytoplasm, Dna Synthesis, Enzyme Inhibition, Gene Silencing, Genotoxicity, Human, Human Cell, Ionizing Radiation, Lymphoblast, Mitosis, Priority Journal, Protein Function, Protein Localization, Protein Phosphorylation, Signal Transduction, Thyroid Tumor, Amino Acid Sequence, Cell Cycle Proteins, Cell Line, Cytoskeletal Proteins, Dna-Binding Proteins, Hela Cells, Molecular Sequence Data, Protein-Serine-Threonine Kinases, Thyroid Neoplasms, Tumor Suppressor Proteins, Mammalia, H4 (d10s170), Airway Obstruction, Brain Damage, Chronic Obstructive Lung Disease, Cognition, Cognitive Defect, Disease Severity, Drawing, Exercise, Hypoxemia, Letter, Major Clinical Study, Prognosis, Risk Assessment, Task Performance,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, University 'Federico II', Naples, Italy
CNR Istituto di Biostrutture e Bioimmagini, Naples, Italy
Dipartimento di Medicina Sperimentale e Clinica, Università 'Magna Graecia', Catanzaro, Italy
Istituto di Endocrinologia Ed Oncologia Sperimentale del CNR, Naples, Italy
University Campus Bio-Medico, Rome, Italy
Italian National Research Center on Aging, Cosenza, Italy
Federico II University School of Medicine, Naples, Italy
Viale della Resistenza Pal. Alfa Scala H, I-87036 Rende (CS), Italy
References:
Bakkenist, C.J., Kastan, M.B., DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003) Nature, 421, pp. 499-50
Canman, C.E., Lim, D.S., The role of ATM in DNA damage responses and cancer (1998) Oncogene, 17, pp. 3301-3308
Caudill, C.M., Zhu, Z., Ciampi, R., Stringer, J.R., Nikiforov, Y.E., Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: A model of carcinogenic chromosomal rearrangement induced by ionizing radiation (2005) J Clin Endocrinol Metab, 90, pp. 2364-2369
Celetti, A., Cerrato, A., Merolla, F., Vitagliano, D., Vecchio, G., Grieco, M., H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: Functional characterization (2004) Oncogene, 23, pp. 109-121
DiTullio Jr, R.A., Mochan, T.A., Venere, M., Bartkova, J., Sehested, M., Bartek, J., 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human (2002) Nat Cell Biol cancer, 4, pp. 998-1002
Fusco, A., Grieco, M., Santoro, M., Berlingieri, M.T., Pilotti, S., Pierotti, M.A., A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases (1987) Nature, 328, pp. 170-172
Goodhead, D.T., Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA (1994) Int J Radiat Biol, 65, pp. 7-17
Grieco, M., Cerrato, A., Santoro, M., Fusco, A., Melillo, R.M., Vecchio, G., Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo (1994) Oncogene, 9, pp. 2531-2535
Hickson, I., Zhao, Y., Richardson, C.J., Green, S.J., Martin, N.M., Orr, A.I., Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM (2004) Cancer Res, 64, pp. 9152-9159
Iliakis, G., Wang, Y., Guan, J., Wang, H., DNA damage checkpoint control in cells exposed to ionizing radiation (2003) Oncogene, 22, pp. 5834-5847
Jhiang, S.M., The RET proto-oncogene in human cancers (2000) Oncogene, 19, pp. 5590-5597
Jossart, G.H., O'Brien, B., Cheng, J.F., Tong, Q., Jhiang, S.M., Duh, Q., A novel multicolor hybridization scheme applied to localization of a transcribed sequence (D10S170/H4) and deletion mapping in the thyroid cancer cell line TPC-1 (1996) Cytogenet Cell Gene, 75, pp. 254-257
Kastan, M., Lim, D.S., The many substrates and functions of ATM (2000) Nat Rev Mol Cell Biol, 1, pp. 179-186
Kim, S.T., Lim, D.S., Canman, C.E., Kastan, M.B., Substrate specificities and identification of putative substrates of ATM kinase family members (1999) J Biol Chem, 274, pp. 37538-37543
Kulkarni, S., Heath, C., Parker, S., Chase, A., Iqbal, S., Pocock, C.F., Fusion of H4/D10S170 to the platelet-derived growth factor receptor beta in BCR-ABL-negative myeloproliferative disorders with a t(5
q21) (2000) Cancer Res, 60, pp. 3592-3598
Laemli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
Lee, J.H., Paull, T.T., Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex (2004) Science, 304, pp. 93-96
Leskov, K.S., Criswell, T., Antonio, S., Li, J., Yang, C.R., Kinsella, T.J., When X-ray-inducible proteins meet DNA double strand break repair (2001) Semin Radiat Oncol, 11, pp. 352-372
Lim, D.S., Kim, S.T., Xu, B., Maser, R.S., Lin, J., Petrini, J.H., ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway (2000) Nature, 404, pp. 613-617
Little, J.B., Genomic instability and bystander effects: A historical perspective (2003) Oncogene, 22, pp. 6978-6987
Motoyama, N., Naka, K., DNA damage tumor suppressor genes and genomic instability (2004) Curr Opin Genet Dev, 14, pp. 11-16
Nikiforova, M.N., Ciampi, R., Salvatore, G., Santoro, M., Gandhi, M., Knauf, J.A., Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas (2004) Cancer Lett, 209, pp. 1-6
Nikiforova, M.N., Stringer, J.R., Blough, R., Medvedovic, M., Fagin, J.A., Nikiforov, Y.E., Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells (2000) Science, 290, pp. 138-141
Obenauer, J.C., Cantley, L.C., Yaffe, M.B., Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs (2003) Nucleic Acids Res, 31, pp. 3635-3641
O'Neill, T., Dwyer, A.J., Ziv, Y., Chan, D.W., Lees-Miller, S.P., Abraham, R.H., Utilization of oriented peptide libraries to identify substrate motifs selected by ATM (2000) J Biol Chem, 275, pp. 22719-22727
Penserga, E.T., Skorski, T., Fusion tyrosine kinases: A result and cause of genomic instability (2007) Oncogene, 26, pp. 11-20
Pierotti, M.A., Santoro, M., Jenkins, R.B., Sozzi, G., Bongarzone, I., Grieco, M., Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC (1992) Proc Natl Acad Sci USA, 89, pp. 1616-1620
Puxeddu, E., Zhao, G., Stringer, J.R., Medvedovic, M., Moretti, S., Fagin, J.A., Characterization of novel non-clonal intrachromosomal rearrangements between the H4 and PTEN genes (H4/PTEN) in human thyroid cell lines and papillary thyroid cancer specimens (2005) Mutat Res, 570, pp. 17-32
Radivoyevitch, T., Sachs, R.K., Nikiforov, Y.E., Nikiforova, M.N., Little, M.P., On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer (2001) Radiat Environ Biophys, 40, pp. 191-197
Ron, E., Lubin, J.H., Shore, R.E., Mabuchi, K., Modan, B., Pottern, L.M., On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer (1995) Radiat Res, 141, pp. 259-277
Schwaller, J., Anastasiadou, E., Cain, D., Kutok, J., Wojiski, S., Williams, I.R., H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5
q22) (2001) Blood, 97, pp. 3910-3918
Sheils, O.M., O'Leary, J.J., Sweeney, E.C., Assessment of ret/PTC-1 rearrangements in neoplastic thyroid tissue using TaqMan RT-PCR (2000) J Pathol, 192, pp. 32-36
Shiloh, Y., ATM: Ready, set, go (2003) Cell Cycle, 2, pp. 116-117
Smith, L.E., Nagar, S., Kim, G.J., Morgan, W.F., Radiation-induced genomic instability: Radiation quality and dose response (2003) Health Phys, 85, pp. 23-29
Tong, Q., Xing, S., Jhiang, S.M., Leucine zipper-mediated dimerization is essential for the PTC1 oncogenic activity (1997) J Biol Chem, 272, pp. 9043-9047
Towbin, H., Staehelin, T., Gordon, J., Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications (1979) Proc Natl Acad Sci USA, 76, pp. 4350-4354
Ward, J.F., Radiation mutagenesis: The initial DNA lesions responsible (1995) Radiat Res, 142, pp. 362-368
Bakkenist, C. J., Kastan, M. B., DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003) Nature, 421, pp. 499-50
Canman, C. E., Lim, D. S., The role of ATM in DNA damage responses and cancer (1998) Oncogene, 17, pp. 3301-3308
Caudill, C. M., Zhu, Z., Ciampi, R., Stringer, J. R., Nikiforov, Y. E., Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: A model of carcinogenic chromosomal rearrangement induced by ionizing radiation (2005) J Clin Endocrinol Metab, 90, pp. 2364-2369
DiTullio Jr, R. A., Mochan, T. A., Venere, M., Bartkova, J., Sehested, M., Bartek, J., 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human (2002) Nat Cell Biol cancer, 4, pp. 998-1002
Goodhead, D. T., Initial events in the cellular effects of ionizing radiations: Clustered damage in DNA (1994) Int J Radiat Biol, 65, pp. 7-17
Jhiang, S. M., The RET proto-oncogene in human cancers (2000) Oncogene, 19, pp. 5590-5597
Jossart, G. H., O'Brien, B., Cheng, J. F., Tong, Q., Jhiang, S. M., Duh, Q., A novel multicolor hybridization scheme applied to localization of a transcribed sequence (D10S170/H4) and deletion mapping in the thyroid cancer cell line TPC-1 (1996) Cytogenet Cell Gene, 75, pp. 254-257
Kim, S. T., Lim, D. S., Canman, C. E., Kastan, M. B., Substrate specificities and identification of putative substrates of ATM kinase family members (1999) J Biol Chem, 274, pp. 37538-37543
Laemli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature, 227, pp. 680-685
Lee, J. H., Paull, T. T., Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex (2004) Science, 304, pp. 93-96
Leskov, K. S., Criswell, T., Antonio, S., Li, J., Yang, C. R., Kinsella, T. J., When X-ray-inducible proteins meet DNA double strand break repair (2001) Semin Radiat Oncol, 11, pp. 352-372
Lim, D. S., Kim, S. T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H., ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway (2000) Nature, 404, pp. 613-617
Little, J. B., Genomic instability and bystander effects: A historical perspective (2003) Oncogene, 22, pp. 6978-6987
Nikiforova, M. N., Ciampi, R., Salvatore, G., Santoro, M., Gandhi, M., Knauf, J. A., Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas (2004) Cancer Lett, 209, pp. 1-6
Obenauer, J. C., Cantley, L. C., Yaffe, M. B., Scansite 2. 0: Proteome-wide prediction of cell signaling interactions using short sequence motifs (2003) Nucleic Acids Res, 31, pp. 3635-3641
Penserga, E. T., Skorski, T., Fusion tyrosine kinases: A result and cause of genomic instability (2007) Oncogene, 26, pp. 11-20
Pierotti, M. A., Santoro, M., Jenkins, R. B., Sozzi, G., Bongarzone, I., Grieco, M., Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC (1992) Proc Natl Acad Sci USA, 89, pp. 1616-1620
Ron, E., Lubin, J. H., Shore, R. E., Mabuchi, K., Modan, B., Pottern, L. M., On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer (1995) Radiat Res, 141, pp. 259-277
Sheils, O. M., O'Leary, J. J., Sweeney, E. C., Assessment of ret/PTC-1 rearrangements in neoplastic thyroid tissue using TaqMan RT-PCR (2000) J Pathol, 192, pp. 32-36
Smith, L. E., Nagar, S., Kim, G. J., Morgan, W. F., Radiation-induced genomic instability: Radiation quality and dose response (2003) Health Phys, 85, pp. 23-29
Ward, J. F., Radiation mutagenesis: The initial DNA lesions responsible (1995) Radiat Res, 142, pp. 362-368
Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage
H4(D10S170) gene has been identified upon its frequent rearrangement with RET in papillary thyroid tumours (RET/PTC1). The kinase ataxia telangectasia mutated (ATM) phosphorylates a limited number of downstream protein targets in response to DNA damage. We investigated the potential role of H4(D10S170) in DNA damage signaling pathways. We found that in cells treated with etoposide or ionizing radiation (IR), H4(D10S170) underwent ATM-mediated phosphorylation at Thr 434, stabilizing nuclear H4. In ataxia telangectasia cells (A-T), endogenous H4(D10S170) was localized to cytoplasm and was excluded from the nucleus. Moreover, H4(D10S170) was not phosphorylated in ATM-deficient lymphoblasts after ionizing irradiation. Inhibition of ATM kinase interfered with H4(D10S170) apoptotic activity, and expression of H4 with threonine 434 mutated in Alanine, H4T434A, protected the cells from genotoxic stress-induced apoptosis. Most importantly, after exposure to IR we found that silencing of H4(D10S170) in mammalian cells increased cell survival, as shown by clonogenic assay, allows for DNA synthesis as evaluated by bromodeoxyuridine incorporation and permits cells to progress into mitosis as demonstrated by phosphorylation on Histone H3. Our results suggest that H4(D10S170) is involved in cellular response to DNA damage ATM-mediated, and that the impairment of H4(D10S170) gene function might have a role in thyroid carcinogenesis. © 2007 Nature Publishing Group All rights reserved.
H4(D10S170) gene has been identified upon its frequent rearrangement with RET in papillary thyroid tumours (RET/PTC1). The kinase ataxia telangectasia mutated (ATM) phosphorylates a limited number of downstream protein targets in response to DNA damage. We investigated the potential role of H4(D10S170) in DNA damage signaling pathways. We found that in cells treated with etoposide or ionizing radiation (IR), H4(D10S170) underwent ATM-mediated phosphorylation at Thr 434, stabilizing nuclear H4. In ataxia telangectasia cells (A-T), endogenous H4(D10S170) was localized to cytoplasm and was excluded from the nucleus. Moreover, H4(D10S170) was not phosphorylated in ATM-deficient lymphoblasts after ionizing irradiation. Inhibition of ATM kinase interfered with H4(D10S170) apoptotic activity, and expression of H4 with threonine 434 mutated in Alanine, H4T434A, protected the cells from genotoxic stress-induced apoptosis. Most importantly, after exposure to IR we found that silencing of H4(D10S170) in mammalian cells increased cell survival, as shown by clonogenic assay, allows for DNA synthesis as evaluated by bromodeoxyuridine incorporation and permits cells to progress into mitosis as demonstrated by phosphorylation on Histone H3. Our results suggest that H4(D10S170) is involved in cellular response to DNA damage ATM-mediated, and that the impairment of H4(D10S170) gene function might have a role in thyroid carcinogenesis. © 2007 Nature Publishing Group All rights reserved.
Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage
Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage
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Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
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Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (569 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
Impact Factor: 4.839
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (462 views)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (623 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
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Esposito L, Banyasz A, Douki T, Perron M, Markovitsi D, Improta R
* Effect of C5-methylation of cytosine on the photoreactivity of DNA: A joint experimental and computational study of TCG trinucleotides (363 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2014 Sep 6; 136(31): 10838-10841.
Impact Factor: 12.113
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Antoniali G, Lirussi L, D'Ambrosio C, Dal Piaz F, Vascotto C, Casarano E, Marasco D, Scaloni A, Fogolari F, Tell G
* SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements (531 views)
Mol Biol Cell (ISSN: 1059-1524), 2014 Feb 15; 25(4): 532-547.
Impact Factor: 4.466
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Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (668 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (594 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (495 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (660 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Riccio A, Cubellis MV
* Gain of function in CDKN1C (503 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
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Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3437 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (490 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
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Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
* HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (856 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Impact Factor: 6.373
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Rachidi W, De Rosa V
Selenium protects against the cytotoxic and genotoxic effects of oxidative stress both as an anti-oxidant and by stimulating DNA damage repair (306 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2011 Mar; 98: N/D-N/D.
Impact Factor: 0.672
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (771 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (509 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (489 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (398 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (410 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Guler OO, De Simone G, Supuran CT
* Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (540 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526.
Impact Factor: 4.63
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, Pensato S, Pedone C, Gulino A, Mackay AR
* The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells (388 views)
Oncogene (ISSN: 1476-5594, 0950-9232), 2009 Nov 19; 28(46): 4075-4094.
Impact Factor: 7.135
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Sandomenico A, Monti SM, Sabatella M, De Capua A, Tornatore L, Doti N, Viparelli F, Dathan NA, Pedone C, Ruvo M, Marasco D
* Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists (558 views)
Chem Biol Drug Des (ISSN: 1747-0285, 1747-0277), 2009 May; 73(5): 483-493.
Impact Factor: 2.473
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Calvanese L, Saporito A, Oliva R, D'Auria G, Pedone C, Paolillo L, Ruvo M, Marasco D, Falcigno L
* Structural insights into the interaction between the Cripto CFC domain and the ALK4 receptor (456 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 175-183.
Impact Factor: 1.807
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
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Tornatore L, Marasco D, Dathan N, Vitale RM, Benedetti E, Papa S, Franzoso G, Ruvo M, Monti SM
* Gadd45 beta forms a homodimeric complex that binds tightly to MKK7 (467 views)
J Mol Biol (ISSN: 0022-2836, 0022-2283, 1089-8638), 2008 Apr 18; 378(1): 97-111.
Impact Factor: 5.673
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (399 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (506 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
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Di Pietro C, Piro S, Tabbì G, Ragusa M, Di Pietro V, Zimmitti V, Cuda F, Anello M, Consoli U, Salinaro ET, Caruso M, Vancheri C, Crimi N, Sabini MG, Cirrone GA, Raffaele L, Privitera G, Pulvirenti A, Giugno R, Ferro A, Cuttone G, Lo Nigro S, Purrello R, Purrello F, Purrello M
* Cellular and molecular effects of protons: Apoptosis induction and potential implications for cancer therapy (520 views)
Apoptosis (ISSN: 1360-8185), 2006 Jan; 11(1): 57-66.
Impact Factor: 3.421
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (348 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (642 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Durante M, Cella L, Furusawa Y, George K, Gialanella G, Grossi G, Pugliese M, Saito M, Yang TC
The effect of track structure on the induction of chromosomal aberrations in murine cells (737 views)
Int J Radiat Biol International Journal Of Radiation Biology (ISSN: 0955-3002), 1998 Mar; 73(3): 253-262.
Impact Factor: 2.579
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (661 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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51 Records (48 excluding Abstracts).
Total impact factor: 276.301 (261.721 excluding Abstracts).
Total 5 year impact factor: 261.695 (247.358 excluding Abstracts).
Total impact factor: 276.301 (261.721 excluding Abstracts).
Total 5 year impact factor: 261.695 (247.358 excluding Abstracts).
606 views. Last view on Tuesday 07 February 2023, 2:09:10
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