CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (371 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
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Paper type: Journal Article,
Impact factor: 4.293, 5-year impact factor: 3.661
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77449105303&partnerID=40&md5=6beed3b6c27d14605fa2166af277ad54
Keywords: Cxcr4, Melanoma, Prognosis, Cd16 Antigen, Cd20 Antigen, Cd3 Antigen, Cd4 Antigen, Cd45ra Antigen, Cd45ro Antigen, Cd56 Antigen, Cd8 Antigen, Chemokine Receptor Cxcr4, Fluorescent Dye, Hla Dr Antigen, Interleukin 2 Receptor Alpha, Monoclonal Antibody, Cd45 Antigen, Cxcr4 Protein, Human, Adult, Aged, Article, Cancer Relapse, Cd4+ T Lymphocyte, Controlled Study, Disease Association, Disease Course, Disease Free Survival, Female, Flow Cytometry, Fluorescence Analysis, Human Cell, Lymphocyte Subpopulation, Major Clinical Study, Overall Survival, Peripheral Lymphocyte, Prediction, Priority Journal, Protein Expression, Risk Assessment, Risk Factor, Cancer Staging, Follow Up, Immunology, Metabolism, Middle Aged, Prospective Study, Skin Tumor, Survival Rate, 80 And Over, Cd4-Positive T-Lymphocytes, Disease Progression, Follow-Up Studies, Neoplasm Staging, Prospective Studies, Skin Neoplasms, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Clinical Immunology, National Cancer Institute, G. Pascale Foundation, via Mariano Semmola, 80131 Naples, Italy
Department of Pathology, National Cancer Institute, 80131 Naples, Italy
Department of Dermatology, Second Medical School, Naples, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale Ricerche, Naples, Italy
Istituto di Medicina e Psicologia Sistemica, Naples, Italy
References:
Tsao, H., Atkins, M.B., Sober, A.J., Management of cutaneous melanoma (2004) N Eng J Med, 351, pp. 998-101
Leiter, U., Meier, F., Schittek, B., The natural course of cutaneous melanoma (2004) J Surg Oncol, 86, pp. 172-178
Slingluff Jr., C.L., Chianese-Bullock, K.A., Bullock, T.N., Immunity to melanoma antigens: From self-tolerance to immunotherapy (2006) Adv Immunol, 90, pp. 243-295
Parmiani, G., Castelli, C., Santinami, M., Rivoltini, L., Melanoma immunology: Past, present and future (2007) Current Opinion in Oncology, 19 (2), pp. 121-127. , DOI 10.1097/CCO.0b013e32801497d7, PII 0000162220070300000010
Moser, B., Wolf, M., Walz, A., Loetscher, P., Chemokines: Multiple levels of leukocyte migration control (2004) Trends in Immunology, 25 (2), pp. 75-84. , DOI 10.1016/j.it.2003.12.005
Muller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., McClanahan, T., Zlotnik, A., Involvement of chemokine receptors in breast cancer metastasis (2001) Nature, 410 (6824), pp. 50-56. , DOI 10.1038/35065016
Balkwill, F., Cancer and the chemokine network (2004) Nat Rev Cancer, 4, pp. 540-550
Scala, S., Ottaiano, A., Ascierto, P.A., Cavalli, M., Simeone, E., Giuliano, P., Napolitano, M., Castello, G., Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma (2005) Clinical Cancer Research, 11 (5), pp. 1835-1841. , DOI 10.1158/1078-0432.CCR-04-1887
Scala, S., Giuliano, P., Ascierto, P.A., Human melanoma metastases express functional CXCR4 (2006) Clin Cancer Res, 12, pp. 2427-2433
Burger, J.A., Kipps, T.J., CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment (2006) Blood, 107, pp. 1761-1767
Bradfield, P.F., Amft, N., Vernon-Wilson, E., Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL 12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue (2003) Arthritis Rheum, 48, pp. 2472-2482
Vianello, F., Papeta, N., Chen, T., Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control (2006) J Immunol, 176, pp. 2902-2914
Mullins, I.M., Slingluff, C.L., Lee, J.K., CXC chemokine receptor 3 expression by activated CD8+ T cells is associated with survival in melanoma patients with stage III disease (2004) Cancer Res, 64, pp. 7697-7701
Kim, S.Y., Lee, C.A., Midura, B.V., Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases (2008) Clin Exp Metastasis, 25, pp. 201-211
Zhang, T., Somasundaram, R., Berking, C., Caputo, L., Van, B., Elder, D., Czerniecki, B., Herlyn, D., Preferential involvement of CX chemokine receptor 4 and CX chemokine ligand 12 in T-cell migration toward melanoma cells (2006) Cancer Biology and Therapy, 5 (10), pp. 1304-1312. , http://www.landesbioscience.com/journals/cbt/zhang5-10.pdf
Beverley, P.C., Functional analysis of human T cell subsets defined by CD45 isoform expression (1992) Semin Immunol, 4, pp. 35-41
Johanninson, A., Festin, R., Phenotype transition of CD4+ T cells from CD45RA to CD45RO is accompanied by cell activation and proliferation (1995) Cytometry, 19, pp. 343-352
Bleul, C.C., Wu, L., Hoxie, J.A., Springer, T.A., Mackay, C.R., The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes (1997) Proceedings of the National Academy of Sciences of the United States of America, 94 (5), pp. 1925-1930. , DOI 10.1073/pnas.94.5.1925
Rabin, R.L., Park, M.K., Liao, F., Swofford, R., Stephany, D., Farber, J.M., Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling (1999) Journal of Immunology, 162 (7), pp. 3840-3850
Wald, O., Uzi, I., Gail, A., CD4+CXCR4highCD69+ T Cells accumulate in lung adenocarcinoma (2006) J Immunol, 177, pp. 6983-6990
Shalekoff, S., Pendle, S., Johnson, D., Martin, D.J., Tiemessen, C.T., Distribution of the human immunodeficiency virus coreceptors CXCR4 and CCR5 on leukocytes of persons with human immunodeficiency virus type 1 infection and pulmonary tuberculosis: Implications for pathogenesis (2001) Journal of Clinical Immunology, 21 (6), pp. 390-401. , DOI 10.1023/A:1013121625962
Slingluff Jr., C. L., Chianese-Bullock, K. A., Bullock, T. N., Immunity to melanoma antigens: From self-tolerance to immunotherapy (2006) Adv Immunol, 90, pp. 243-295
Burger, J. A., Kipps, T. J., CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment (2006) Blood, 107, pp. 1761-1767
Bradfield, P. F., Amft, N., Vernon-Wilson, E., Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL 12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue (2003) Arthritis Rheum, 48, pp. 2472-2482
Mullins, I. M., Slingluff, C. L., Lee, J. K., CXC chemokine receptor 3 expression by activated CD8+ T cells is associated with survival in melanoma patients with stage III disease (2004) Cancer Res, 64, pp. 7697-7701
Kim, S. Y., Lee, C. A., Midura, B. V., Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases (2008) Clin Exp Metastasis, 25, pp. 201-211
Beverley, P. C., Functional analysis of human T cell subsets defined by CD45 isoform expression (1992) Semin Immunol, 4, pp. 35-41
Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A., Mackay, C. R., The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes (1997) Proceedings of the National Academy of Sciences of the United States of America, 94 (5), pp. 1925-1930. , DOI 10. 1073/pnas. 94. 5. 1925
Rabin, R. L., Park, M. K., Liao, F., Swofford, R., Stephany, D., Farber, J. M., Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling (1999) Journal of Immunology, 162 (7), pp. 3840-3850
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.293, 5-year impact factor: 3.661
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77449105303&partnerID=40&md5=6beed3b6c27d14605fa2166af277ad54
Keywords: Cxcr4, Melanoma, Prognosis, Cd16 Antigen, Cd20 Antigen, Cd3 Antigen, Cd4 Antigen, Cd45ra Antigen, Cd45ro Antigen, Cd56 Antigen, Cd8 Antigen, Chemokine Receptor Cxcr4, Fluorescent Dye, Hla Dr Antigen, Interleukin 2 Receptor Alpha, Monoclonal Antibody, Cd45 Antigen, Cxcr4 Protein, Human, Adult, Aged, Article, Cancer Relapse, Cd4+ T Lymphocyte, Controlled Study, Disease Association, Disease Course, Disease Free Survival, Female, Flow Cytometry, Fluorescence Analysis, Human Cell, Lymphocyte Subpopulation, Major Clinical Study, Overall Survival, Peripheral Lymphocyte, Prediction, Priority Journal, Protein Expression, Risk Assessment, Risk Factor, Cancer Staging, Follow Up, Immunology, Metabolism, Middle Aged, Prospective Study, Skin Tumor, Survival Rate, 80 And Over, Cd4-Positive T-Lymphocytes, Disease Progression, Follow-Up Studies, Neoplasm Staging, Prospective Studies, Skin Neoplasms, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Clinical Immunology, National Cancer Institute, G. Pascale Foundation, via Mariano Semmola, 80131 Naples, Italy
Department of Pathology, National Cancer Institute, 80131 Naples, Italy
Department of Dermatology, Second Medical School, Naples, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale Ricerche, Naples, Italy
Istituto di Medicina e Psicologia Sistemica, Naples, Italy
References:
Tsao, H., Atkins, M.B., Sober, A.J., Management of cutaneous melanoma (2004) N Eng J Med, 351, pp. 998-101
Leiter, U., Meier, F., Schittek, B., The natural course of cutaneous melanoma (2004) J Surg Oncol, 86, pp. 172-178
Slingluff Jr., C.L., Chianese-Bullock, K.A., Bullock, T.N., Immunity to melanoma antigens: From self-tolerance to immunotherapy (2006) Adv Immunol, 90, pp. 243-295
Parmiani, G., Castelli, C., Santinami, M., Rivoltini, L., Melanoma immunology: Past, present and future (2007) Current Opinion in Oncology, 19 (2), pp. 121-127. , DOI 10.1097/CCO.0b013e32801497d7, PII 0000162220070300000010
Moser, B., Wolf, M., Walz, A., Loetscher, P., Chemokines: Multiple levels of leukocyte migration control (2004) Trends in Immunology, 25 (2), pp. 75-84. , DOI 10.1016/j.it.2003.12.005
Muller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., McClanahan, T., Zlotnik, A., Involvement of chemokine receptors in breast cancer metastasis (2001) Nature, 410 (6824), pp. 50-56. , DOI 10.1038/35065016
Balkwill, F., Cancer and the chemokine network (2004) Nat Rev Cancer, 4, pp. 540-550
Scala, S., Ottaiano, A., Ascierto, P.A., Cavalli, M., Simeone, E., Giuliano, P., Napolitano, M., Castello, G., Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma (2005) Clinical Cancer Research, 11 (5), pp. 1835-1841. , DOI 10.1158/1078-0432.CCR-04-1887
Scala, S., Giuliano, P., Ascierto, P.A., Human melanoma metastases express functional CXCR4 (2006) Clin Cancer Res, 12, pp. 2427-2433
Burger, J.A., Kipps, T.J., CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment (2006) Blood, 107, pp. 1761-1767
Bradfield, P.F., Amft, N., Vernon-Wilson, E., Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL 12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue (2003) Arthritis Rheum, 48, pp. 2472-2482
Vianello, F., Papeta, N., Chen, T., Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control (2006) J Immunol, 176, pp. 2902-2914
Mullins, I.M., Slingluff, C.L., Lee, J.K., CXC chemokine receptor 3 expression by activated CD8+ T cells is associated with survival in melanoma patients with stage III disease (2004) Cancer Res, 64, pp. 7697-7701
Kim, S.Y., Lee, C.A., Midura, B.V., Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases (2008) Clin Exp Metastasis, 25, pp. 201-211
Zhang, T., Somasundaram, R., Berking, C., Caputo, L., Van, B., Elder, D., Czerniecki, B., Herlyn, D., Preferential involvement of CX chemokine receptor 4 and CX chemokine ligand 12 in T-cell migration toward melanoma cells (2006) Cancer Biology and Therapy, 5 (10), pp. 1304-1312. , http://www.landesbioscience.com/journals/cbt/zhang5-10.pdf
Beverley, P.C., Functional analysis of human T cell subsets defined by CD45 isoform expression (1992) Semin Immunol, 4, pp. 35-41
Johanninson, A., Festin, R., Phenotype transition of CD4+ T cells from CD45RA to CD45RO is accompanied by cell activation and proliferation (1995) Cytometry, 19, pp. 343-352
Bleul, C.C., Wu, L., Hoxie, J.A., Springer, T.A., Mackay, C.R., The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes (1997) Proceedings of the National Academy of Sciences of the United States of America, 94 (5), pp. 1925-1930. , DOI 10.1073/pnas.94.5.1925
Rabin, R.L., Park, M.K., Liao, F., Swofford, R., Stephany, D., Farber, J.M., Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling (1999) Journal of Immunology, 162 (7), pp. 3840-3850
Wald, O., Uzi, I., Gail, A., CD4+CXCR4highCD69+ T Cells accumulate in lung adenocarcinoma (2006) J Immunol, 177, pp. 6983-6990
Shalekoff, S., Pendle, S., Johnson, D., Martin, D.J., Tiemessen, C.T., Distribution of the human immunodeficiency virus coreceptors CXCR4 and CCR5 on leukocytes of persons with human immunodeficiency virus type 1 infection and pulmonary tuberculosis: Implications for pathogenesis (2001) Journal of Clinical Immunology, 21 (6), pp. 390-401. , DOI 10.1023/A:1013121625962
Slingluff Jr., C. L., Chianese-Bullock, K. A., Bullock, T. N., Immunity to melanoma antigens: From self-tolerance to immunotherapy (2006) Adv Immunol, 90, pp. 243-295
Burger, J. A., Kipps, T. J., CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment (2006) Blood, 107, pp. 1761-1767
Bradfield, P. F., Amft, N., Vernon-Wilson, E., Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL 12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue (2003) Arthritis Rheum, 48, pp. 2472-2482
Mullins, I. M., Slingluff, C. L., Lee, J. K., CXC chemokine receptor 3 expression by activated CD8+ T cells is associated with survival in melanoma patients with stage III disease (2004) Cancer Res, 64, pp. 7697-7701
Kim, S. Y., Lee, C. A., Midura, B. V., Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases (2008) Clin Exp Metastasis, 25, pp. 201-211
Beverley, P. C., Functional analysis of human T cell subsets defined by CD45 isoform expression (1992) Semin Immunol, 4, pp. 35-41
Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A., Mackay, C. R., The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes (1997) Proceedings of the National Academy of Sciences of the United States of America, 94 (5), pp. 1925-1930. , DOI 10. 1073/pnas. 94. 5. 1925
Rabin, R. L., Park, M. K., Liao, F., Swofford, R., Stephany, D., Farber, J. M., Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling (1999) Journal of Immunology, 162 (7), pp. 3840-3850
CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients
The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I-III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the chi(2) test. The Kaplan-Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by CD4(+)CD45RA(+)CXCR4(+) higher than 25% of PBL showed a longer DFS. Conversely, CD4(+)CD45RA(+)CXCR4(+) < 25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with CD4(+)CD45RA(+)CXCR4(+) lymphocytes < 25% of PBL, and 94% for patients with CD4(+)CD45RA(+)CXCR4(+) > 25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the CD4(+)CD45RA(+)CXCR4(+) lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset CD4(+)CD45RA(+)CXCR4(+) is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers.
The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I-III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the chi(2) test. The Kaplan-Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by CD4(+)CD45RA(+)CXCR4(+) higher than 25% of PBL showed a longer DFS. Conversely, CD4(+)CD45RA(+)CXCR4(+) < 25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with CD4(+)CD45RA(+)CXCR4(+) lymphocytes < 25% of PBL, and 94% for patients with CD4(+)CD45RA(+)CXCR4(+) > 25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the CD4(+)CD45RA(+)CXCR4(+) lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset CD4(+)CD45RA(+)CXCR4(+) is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers.
CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients
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CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients
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* Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients (417 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015; 6(10): 8261-8270.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U
* The Structure Of The Cd3 Zeta Zeta Transmembrane Dimer In Popc And Raft-Like Lipid Bilayer: A Molecular Dynamics Study (442 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002e, 0005-2736print), 2013 Nov; 1828(11): 2637-2645.
Impact Factor: 3.498
View Export to BibTeX Export to EndNote
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* Novel molecular targets for systemic lupus erythematosus (369 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
View Export to BibTeX Export to EndNote
3 Records (3 excluding Abstracts).
Total impact factor: 12.103 (12.103 excluding Abstracts).
Total 5 year impact factor: 12.515 (12.515 excluding Abstracts).
Total impact factor: 12.103 (12.103 excluding Abstracts).
Total 5 year impact factor: 12.515 (12.515 excluding Abstracts).
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