CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (680 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
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Paper type: Journal Article,
Impact factor: 4.293, 5-year impact factor: 3.661
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77449105303&partnerID=40&md5=6beed3b6c27d14605fa2166af277ad54
Keywords: Cxcr4, Melanoma, Prognosis, Cd16 Antigen, Cd20 Antigen, Cd3 Antigen, Cd4 Antigen, Cd45ra Antigen, Cd45ro Antigen, Cd56 Antigen, Cd8 Antigen, Chemokine Receptor Cxcr4, Fluorescent Dye, Hla Dr Antigen, Interleukin 2 Receptor Alpha, Monoclonal Antibody, Cd45 Antigen, Cxcr4 Protein, Human, Adult, Aged, Article, Cancer Relapse, Cd4+ T Lymphocyte, Controlled Study, Disease Association, Disease Course, Disease Free Survival, Female, Flow Cytometry, Fluorescence Analysis, Human Cell, Lymphocyte Subpopulation, Major Clinical Study, Overall Survival, Peripheral Lymphocyte, Prediction, Priority Journal, Protein Expression, Risk Assessment, Risk Factor, Cancer Staging, Follow Up, Immunology, Metabolism, Middle Aged, Prospective Study, Skin Tumor, Survival Rate, 80 And Over, Cd4-Positive T-Lymphocytes, Disease Progression, Follow-Up Studies, Neoplasm Staging, Prospective Studies, Skin Neoplasms, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Clinical Immunology, National Cancer Institute, G. Pascale Foundation, via Mariano Semmola, 80131 Naples, Italy
Department of Pathology, National Cancer Institute, 80131 Naples, Italy
Department of Dermatology, Second Medical School, Naples, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale Ricerche, Naples, Italy
Istituto di Medicina e Psicologia Sistemica, Naples, Italy
References:
Not available.
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.293, 5-year impact factor: 3.661
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77449105303&partnerID=40&md5=6beed3b6c27d14605fa2166af277ad54
Keywords: Cxcr4, Melanoma, Prognosis, Cd16 Antigen, Cd20 Antigen, Cd3 Antigen, Cd4 Antigen, Cd45ra Antigen, Cd45ro Antigen, Cd56 Antigen, Cd8 Antigen, Chemokine Receptor Cxcr4, Fluorescent Dye, Hla Dr Antigen, Interleukin 2 Receptor Alpha, Monoclonal Antibody, Cd45 Antigen, Cxcr4 Protein, Human, Adult, Aged, Article, Cancer Relapse, Cd4+ T Lymphocyte, Controlled Study, Disease Association, Disease Course, Disease Free Survival, Female, Flow Cytometry, Fluorescence Analysis, Human Cell, Lymphocyte Subpopulation, Major Clinical Study, Overall Survival, Peripheral Lymphocyte, Prediction, Priority Journal, Protein Expression, Risk Assessment, Risk Factor, Cancer Staging, Follow Up, Immunology, Metabolism, Middle Aged, Prospective Study, Skin Tumor, Survival Rate, 80 And Over, Cd4-Positive T-Lymphocytes, Disease Progression, Follow-Up Studies, Neoplasm Staging, Prospective Studies, Skin Neoplasms, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Clinical Immunology, National Cancer Institute, G. Pascale Foundation, via Mariano Semmola, 80131 Naples, Italy
Department of Pathology, National Cancer Institute, 80131 Naples, Italy
Department of Dermatology, Second Medical School, Naples, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale Ricerche, Naples, Italy
Istituto di Medicina e Psicologia Sistemica, Naples, Italy
References:
Not available.
CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients
The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I-III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the chi(2) test. The Kaplan-Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by CD4(+)CD45RA(+)CXCR4(+) higher than 25% of PBL showed a longer DFS. Conversely, CD4(+)CD45RA(+)CXCR4(+) < 25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with CD4(+)CD45RA(+)CXCR4(+) lymphocytes < 25% of PBL, and 94% for patients with CD4(+)CD45RA(+)CXCR4(+) > 25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the CD4(+)CD45RA(+)CXCR4(+) lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset CD4(+)CD45RA(+)CXCR4(+) is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers.
The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I-III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the chi(2) test. The Kaplan-Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by CD4(+)CD45RA(+)CXCR4(+) higher than 25% of PBL showed a longer DFS. Conversely, CD4(+)CD45RA(+)CXCR4(+) < 25% increased the risk of relapse. The 5-year DFS rate was 76% for patients with CD4(+)CD45RA(+)CXCR4(+) lymphocytes < 25% of PBL, and 94% for patients with CD4(+)CD45RA(+)CXCR4(+) > 25% (p = 0.030 at log-rank test). Univariate and multivariate analysis for DFS confirmed the prognostic value of the CD4(+)CD45RA(+)CXCR4(+) lymphocytes. Although further studies are needed to better define the involved subpopulation, the detection of cellular subset CD4(+)CD45RA(+)CXCR4(+) is an easy and feasible evaluation of melanoma patients in concomitance with the established melanoma prognostic markers.
CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients
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CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients
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Napolitano M, D'Alterio C, Cardone E, Trotta AM, Pecori B, Rega D, Pace U, Scala D, Scognamiglio G, Tatangelo F, Cacciapuoti C, Pacelli R, Delrio P, Scala S
* Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients (933 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015; 6(10): 8261-8270.
Impact Factor: 5.008
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Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U
* The Structure Of The Cd3 Zeta Zeta Transmembrane Dimer In Popc And Raft-Like Lipid Bilayer: A Molecular Dynamics Study (807 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002e, 0005-2736print), 2013 Nov; 1828(11): 2637-2645.
Impact Factor: 3.498
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (725 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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* Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients (933 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015; 6(10): 8261-8270.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Petruk AA, Varriale S, Coscia MR, Mazzarella L, Merlino A, Oreste U
* The Structure Of The Cd3 Zeta Zeta Transmembrane Dimer In Popc And Raft-Like Lipid Bilayer: A Molecular Dynamics Study (807 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002e, 0005-2736print), 2013 Nov; 1828(11): 2637-2645.
Impact Factor: 3.498
View Export to BibTeX Export to EndNote
Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (725 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
View Export to BibTeX Export to EndNote
3 Records (3 excluding Abstracts).
Total impact factor: 12.103 (12.103 excluding Abstracts).
Total 5 year impact factor: 12.515 (12.515 excluding Abstracts).
Total impact factor: 12.103 (12.103 excluding Abstracts).
Total 5 year impact factor: 12.515 (12.515 excluding Abstracts).
680 views. Last view on Saturday 26 April 2025, 1:17:57
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