Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 3.73, 5-year impact factor: 4.244
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84861399281&partnerID=40&md5=65d8419d006c9909cfdcd55c0684d257
Keywords: Histone H2ax, Phosphatase, Phosphoprotein Phosphatase, Phosphoprotein Phosphatase 4c, Protein Ph2ax, Unclassified Drug, Ccdc6 Protein, Human, Cytoskeleton Protein, H2afx Protein, Article, Carcinogenesis, Catalysis, Ccdc6 Gene, Cell Cycle Arrest, Cell Cycle G2 Phase, Cell Loss, Cell Maturation, Cell Transport, Controlled Study, Dna Damage, Dna Repair, Enzyme Activation, Enzyme Activity, Gene Function, Gene Fusion, Gene Inactivation, Gene Interaction, Gene Loss, Genetic Conservation, Genomic Instability, Genotoxicity, High Throughput Screening, Human Cell, Mitosis, Protein Analysis, Protein Dephosphorylation, Protein Interaction, Cell Line, Gene Silencing, Hela Cell, Metabolism, Neoplasm, Cytoskeletal Proteins,
Affiliations:
*** IBB - CNR ***
Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, Naples, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università Federico II, Naples, Italy
Department of Molecular Biology and Microbiology, College of Medicine, University of Central Florida, Orlando, FL, United States
Dipartimento di Scienze Biomorfologiche e Funzionali, Università Federico II, Naples, Italy
References:
Gandhi, M., Evdokimova, V., Nikiforov, Y.E., Mechanisms of chromosomal rearrangements in solid tumours: the model of papillary thyroid carcinoma (2010) Mol Cell Endocrinol, 321, pp. 36-4
Deininger, M.W., Bose, S., Gora-Tybor, J., Yan, X.H., Goldman, J.M., Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation (1998) Cancer Res, 58, pp. 421-425
Dainiak, N., Mechanisms of radiation injury: impact of molecular medicine (1997) Stem Cells, 2, pp. 1-5
Nikiforov, Y.E., Radiation-induced thyroid cancer: what we have learned from Chernobyl (2006) Endocr Pathos, 17, pp. 307-317
Caudill, C.M., Zhu, Z., Ciampi, R., Stringer, J.R., Nikiforov, Y.E., Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation (2005) J Clin Endocrinol Metab, 90, pp. 2364-2369
Fusco, A., Grieco, M., Santoro, M., Berlingieri, M.T., Pilotti, S., A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases (1987) Nature, 328, pp. 170-172
Ron, E., Lubin, J.H., Shore, R.E., Mabuchi, K., Modan, B., (1995) Radiat Res, 141, pp. 259-277
Takeuchi, K., Soda, M., Togashi, Y., Suzuki, R., Sakata, S., RET, ROS1 and ALK fusions in lung cancer (2012) Nat Med Feb, 12. , doi, 10.1038/nm.2658. [Epub ahead of print]
Tong, Q., Xing, S., Jhiang, S.M., (1997) J Biol Chem, 272, pp. 9043-9047
Jhiang, S.M., The RET proto-oncogene in human cancers (2000) Oncogene, 19, pp. 5590-5597
Beausoleil, S.A., Jedrychowski, M., Schwartz, D., Elias, J.E., Villén, J., Large-scale characterization of HeLa cell nuclear phosphoproteins (2004) Proc Natl Acad Sci U S A, 101, pp. 12130-12135
Brill, L.M., Salomon, A.R., Ficarro, S.B., Mukherji, M., Stettler-Gill, M., Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry (2004) Anal Chem, 76, pp. 2763-2772
Grieco, M., Cerrato, A., Santoro, M., Fusco, A., Melillo, R.M., Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo (1994) Oncogene, 9, pp. 2531-2535
Celetti, A., Cerrato, A., Merolla, F., Vitagliano, D., Vecchio, G., H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization (2004) Oncogene, 23, pp. 109-121
Merolla, F., Pentimalli, F., Pacelli, R., Vecchio, G., Fusco, A., Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (2007) Oncogene, 26, pp. 6167-6175
Leone, V., Mansueto, G., Pierantoni, G.M., Tornincasa, M., Merolla, F., CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1 (2010) Oncogene, 29, pp. 4341-4351
Hoeijmakers, J.H., Genome maintenance mechanisms for preventing cancer (2001) Nature, 411, pp. 366-374
Bartek, J., Lukas, J., DNA damage checkpoints: from initiation to recovery or adaptation (2007) Curr Opin Cell Biol, 19, pp. 238-245
Harper, J.W., Elledge, S.J., The DNA damage response: ten years after (2007) Mol Cell, 28, pp. 739-745
Kastan, M.B., Bartek, J., Cell-cycle checkpoints and cancer (2004) Nature, 432, pp. 312-316
Shiloh, Y., ATM and related protein kinases: safeguarding genome integrity (2003) Nat Rev Cancer, 3, pp. 155-156
Zhou, B.B., Elledge, S.J., The DNA damage response: putting checkpoints in perspective (2000) Nature, 408, pp. 433-439
Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S., Bonner, W.M., DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 (1998) J Biol Chem, 273, pp. 5858-5868
Fernandez-Capetillo, O., Lee, A., Nussenzweig, M., Nussenzweig, A., H2AX: the histone guardian of the genome (2004) DNA Repair (Amst), 3, pp. 959-967
Ewing, R.M., Chu, P., Elisma, F., Li, H., Taylor, P., Large-scale mapping of human protein-protein interactions by mass spectrometry (2007) Mol Syst Biol, 3, p. 89
Nakada, S., Chen, G.I., Gingras, A.C., Durocher, D., PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint (2008) EMBO Rep, 9, pp. 1012-1019
Lee, J.H., Paull, T.T., ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex (2005) Science, 308, pp. 551-554
Daniel, J.A., Pellegrini, M., Lee, J.H., Paull, T.T., Feigenbaum, L., Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo (2008) J Cell Biol, 183, pp. 777-783
Tsai, I.C., Hsieh, Y.J., Lyu, P.C., Yu, J.S., Anti-phosphopeptide antibody, P-STM as a novel tool for detecting mitotic phosphoproteins: identification of lamins A and C as two major targets (2005) J Cell Biochem, 94, pp. 967-981
Lazzaro, F., Giannattasio, M., Puddu, F., Granata, M., Pellicioli, A., Checkpoint mechanisms at the intersection between DNA damage and repair (2009) DNA Repair (Amst), 8, pp. 1055-1067
Speit, G., Hartmann, A., The contribution of excision repair to the DNA-effects seen in the alkaline single cell gel test (comet assay) (1995) Mutagenesis, 10, pp. 555-559
DiBiase, S.J., Guan, J., Curran Jr., W.J., Iliakis, G., Repair of DNA double- strand breaks and radiosensitivity to killing in an isogenic group of p53 mutant cell lines (1999) Int. J. Radiat. Oncol. Biol. Phys, 45, pp. 743-751
Mao Zhiyong, Bozzella, M., Seluanov, A., Gorbunova, V., Comparison of nonhomologous end joining and homologous recombination in human cells (2008) DNA Repair (Amst), 10, pp. 1765-1771
Cohen, P.T., Philp, A., Vázquez-Martin, C., Protein phosphatase 4-from obscurity to vital functions (2005) FEBS Lett, 579, p. 3278
Chowdhury, D., Xu, X., Zhong, X., Ahmed, F., Zhong, J., A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication (2008) Mol Cell, 31, pp. 33-46
Zhou, G., Boomer, J.S., Tan, T.H., Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1 (2004) J Biol Chem, 279, pp. 49551-49561
Tung, H.Y., Alemany, S., Cohen, P., The protein phosphatases involved in cellular regulation. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle (1985) Eur J Biochem, 148, pp. 253-263
Jossart, G.H., O'Brien, B., Cheng, J.F., Tong, Q., Jhiang, S.M., (1996) Cytogenetics and Cell Genetics, 75, pp. 254-257
Chen, G.I., Tisayakorn, S., Jorgensen, C., D'Ambrosio, L.M., Goudreault, M., PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 (2008) J Biol Chem, 283, pp. 29273-29284
Lee, D.H., Pan, Y., Kanner, S., Sung, P., Borowiec, J.A., A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination (2010) Nat Struct Mol Biol, 17, pp. 365-372
Zhang, X., Ozawa, Y., Lee, H., Wen, Y.D., Tan, T.H., Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4 (2005) Genes Dev, 19, pp. 827-839
Zhou, G., Mihindukulasuriya, K.A., MacCorkle-Chosnek, R.A., van Hooser, A., Hu, M.C., Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase (2002) J Biol Chem, 277, pp. 6391-6398
Glatter, T., Wepf, A., Aebersoldand, R., Gstaiger, M., An integrated workflow for charting the human interaction proteome: insights into the PP2A system (2009) Molecular Systems Biology, 5, p. 237
Chowdhury, D., Keogh, M.C., Ishii, H., Peterson, C.L., Buratowski, gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair (2005) Mol Cell, 20, pp. 801-809
Keogh, M.C., Kim, J.A., Downey, M., Fillingham, J., Chowdhury, D., A phosphatase complex that dephosphorylates gamma H2AX regulates DNA damage checkpoint recovery (2006) Nature, 439, pp. 497-501
Douglas, P., Zhong, J., Ye, R., Moorhead, G.B., Xu, X., Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX (2010) Mol Cell Biol, 30, pp. 1368-1381
Macůrek, L., Lindqvist, A., Voets, O., Kool, J., Vos, H.R., Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition (2010) Oncogene, 29, pp. 2281-2291
Freeman, A.K., Monteiro, A.N., Phosphatases in the cellular response to DNA damage (2010) Cell Commun Signal, 8, p. 27
Wang, B., Zhao, A., Sun, L., Zhong, X., Zhong, J., Protein phosphatase PP4 is overexpressed in human breast and lung tumours (2008) Cell Res, 18, pp. 974-977
Kulkarni, S., Heath, C., Parker, S., Vhase, A., Iqbal, (2000) Cancer Research, 60, pp. 3592-3598
Schwaller, J., Anastasiadou, E., Cain, D., Kutok, J., Wojiski, S., (2001) Blood, 97, pp. 3910-3918
Puxeddu, E., Knauf, J.A., Sartor, M.A., Mitsutake, N., Smith, E.P., RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response (2005) Endocr Relat Cancer, 12, pp. 313-319
Drechsler, M., Hildebrandt, B., Kundgen, A., Germing, U., Royer-Pokora, B., Fusion of H4/D10S170 to PDGFRbeta in a patient with chronic myelomonocytic leukemia and long-term responsiveness to imatinib (2007) Ann Hematol, 86, pp. 353-354
Halazonetis, T.D., Gorgoulis, V.G., Bartek, J., An oncogene-induced DNA damage model for cancer development (2008) Science, 319, pp. 1352-1355
Pear, W.S., Nolan, G.P., Scott, M.L., Baltimore, D., Production of high-titer helper-free retroviruses by transient transfection (1993) Proc Natl Acad Sci U S A, 90, pp. 8392-8396
Scherer, W.F., Syverton, J.T., Gey, G.O., Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix (1953) J Exp Med, 97, pp. 695-710
Hanada, K., Budzowska, M., Davies, S.L., van Drunen, E., Onizawa, H., (2007) Nature Struc Mol Biol, 14, pp. 1096-1104
Macurek, L., Lindqvist, A., Voets, O., Kool, J., Vos, H.R., Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition (2010) Oncogene, 29, pp. 2281-2291
Deininger, M. W., Bose, S., Gora-Tybor, J., Yan, X. H., Goldman, J. M., Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation (1998) Cancer Res, 58, pp. 421-425
Nikiforov, Y. E., Radiation-induced thyroid cancer: what we have learned from Chernobyl (2006) Endocr Pathos, 17, pp. 307-317
Caudill, C. M., Zhu, Z., Ciampi, R., Stringer, J. R., Nikiforov, Y. E., Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation (2005) J Clin Endocrinol Metab, 90, pp. 2364-2369
Ron, E., Lubin, J. H., Shore, R. E., Mabuchi, K., Modan, B., (1995) Radiat Res, 141, pp. 259-277
Jhiang, S. M., The RET proto-oncogene in human cancers (2000) Oncogene, 19, pp. 5590-5597
Beausoleil, S. A., Jedrychowski, M., Schwartz, D., Elias, J. E., Vill n, J., Large-scale characterization of HeLa cell nuclear phosphoproteins (2004) Proc Natl Acad Sci U S A, 101, pp. 12130-12135
Brill, L. M., Salomon, A. R., Ficarro, S. B., Mukherji, M., Stettler-Gill, M., Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry (2004) Anal Chem, 76, pp. 2763-2772
Hoeijmakers, J. H., Genome maintenance mechanisms for preventing cancer (2001) Nature, 411, pp. 366-374
Harper, J. W., Elledge, S. J., The DNA damage response: ten years after (2007) Mol Cell, 28, pp. 739-745
Kastan, M. B., Bartek, J., Cell-cycle checkpoints and cancer (2004) Nature, 432, pp. 312-316
Zhou, B. B., Elledge, S. J., The DNA damage response: putting checkpoints in perspective (2000) Nature, 408, pp. 433-439
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., Bonner, W. M., DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 (1998) J Biol Chem, 273, pp. 5858-5868
Ewing, R. M., Chu, P., Elisma, F., Li, H., Taylor, P., Large-scale mapping of human protein-protein interactions by mass spectrometry (2007) Mol Syst Biol, 3, p. 89
Lee, J. H., Paull, T. T., ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex (2005) Science, 308, pp. 551-554
Daniel, J. A., Pellegrini, M., Lee, J. H., Paull, T. T., Feigenbaum, L., Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo (2008) J Cell Biol, 183, pp. 777-783
Tsai, I. C., Hsieh, Y. J., Lyu, P. C., Yu, J. S., Anti-phosphopeptide antibody, P-STM as a novel tool for detecting mitotic phosphoproteins: identification of lamins A and C as two major targets (2005) J Cell Biochem, 94, pp. 967-981
DiBiase, S. J., Guan, J., Curran Jr., W. J., Iliakis, G., Repair of DNA double- strand breaks and radiosensitivity to killing in an isogenic group of p53 mutant cell lines (1999) Int. J. Radiat. Oncol. Biol. Phys, 45, pp. 743-751
Cohen, P. T., Philp, A., V zquez-Martin, C., Protein phosphatase 4-from obscurity to vital functions (2005) FEBS Lett, 579, p. 3278
Tung, H. Y., Alemany, S., Cohen, P., The protein phosphatases involved in cellular regulation. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle (1985) Eur J Biochem, 148, pp. 253-263
Jossart, G. H., O'Brien, B., Cheng, J. F., Tong, Q., Jhiang, S. M., (1996) Cytogenetics and Cell Genetics, 75, pp. 254-257
Chen, G. I., Tisayakorn, S., Jorgensen, C., D'Ambrosio, L. M., Goudreault, M., PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 (2008) J Biol Chem, 283, pp. 29273-29284
Lee, D. H., Pan, Y., Kanner, S., Sung, P., Borowiec, J. A., A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination (2010) Nat Struct Mol Biol, 17, pp. 365-372
Keogh, M. C., Kim, J. A., Downey, M., Fillingham, J., Chowdhury, D., A phosphatase complex that dephosphorylates gamma H2AX regulates DNA damage checkpoint recovery (2006) Nature, 439, pp. 497-501
Mac rek, L., Lindqvist, A., Voets, O., Kool, J., Vos, H. R., Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition (2010) Oncogene, 29, pp. 2281-2291
Freeman, A. K., Monteiro, A. N., Phosphatases in the cellular response to DNA damage (2010) Cell Commun Signal, 8, p. 27
Halazonetis, T. D., Gorgoulis, V. G., Bartek, J., An oncogene-induced DNA damage model for cancer development (2008) Science, 319, pp. 1352-1355
Pear, W. S., Nolan, G. P., Scott, M. L., Baltimore, D., Production of high-titer helper-free retroviruses by transient transfection (1993) Proc Natl Acad Sci U S A, 90, pp. 8392-8396
Scherer, W. F., Syverton, J. T., Gey, G. O., Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix (1953) J Exp Med, 97, pp. 695-710
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 3.73, 5-year impact factor: 4.244
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84861399281&partnerID=40&md5=65d8419d006c9909cfdcd55c0684d257
Keywords: Histone H2ax, Phosphatase, Phosphoprotein Phosphatase, Phosphoprotein Phosphatase 4c, Protein Ph2ax, Unclassified Drug, Ccdc6 Protein, Human, Cytoskeleton Protein, H2afx Protein, Article, Carcinogenesis, Catalysis, Ccdc6 Gene, Cell Cycle Arrest, Cell Cycle G2 Phase, Cell Loss, Cell Maturation, Cell Transport, Controlled Study, Dna Damage, Dna Repair, Enzyme Activation, Enzyme Activity, Gene Function, Gene Fusion, Gene Inactivation, Gene Interaction, Gene Loss, Genetic Conservation, Genomic Instability, Genotoxicity, High Throughput Screening, Human Cell, Mitosis, Protein Analysis, Protein Dephosphorylation, Protein Interaction, Cell Line, Gene Silencing, Hela Cell, Metabolism, Neoplasm, Cytoskeletal Proteins,
Affiliations:
*** IBB - CNR ***
Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, Naples, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università Federico II, Naples, Italy
Department of Molecular Biology and Microbiology, College of Medicine, University of Central Florida, Orlando, FL, United States
Dipartimento di Scienze Biomorfologiche e Funzionali, Università Federico II, Naples, Italy
References:
Gandhi, M., Evdokimova, V., Nikiforov, Y.E., Mechanisms of chromosomal rearrangements in solid tumours: the model of papillary thyroid carcinoma (2010) Mol Cell Endocrinol, 321, pp. 36-4
Deininger, M.W., Bose, S., Gora-Tybor, J., Yan, X.H., Goldman, J.M., Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation (1998) Cancer Res, 58, pp. 421-425
Dainiak, N., Mechanisms of radiation injury: impact of molecular medicine (1997) Stem Cells, 2, pp. 1-5
Nikiforov, Y.E., Radiation-induced thyroid cancer: what we have learned from Chernobyl (2006) Endocr Pathos, 17, pp. 307-317
Caudill, C.M., Zhu, Z., Ciampi, R., Stringer, J.R., Nikiforov, Y.E., Dose-dependent generation of RET/PTC in human thyroid cells after in vitro exposure to gamma-radiation: a model of carcinogenic chromosomal rearrangement induced by ionizing radiation (2005) J Clin Endocrinol Metab, 90, pp. 2364-2369
Fusco, A., Grieco, M., Santoro, M., Berlingieri, M.T., Pilotti, S., A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases (1987) Nature, 328, pp. 170-172
Ron, E., Lubin, J.H., Shore, R.E., Mabuchi, K., Modan, B., (1995) Radiat Res, 141, pp. 259-277
Takeuchi, K., Soda, M., Togashi, Y., Suzuki, R., Sakata, S., RET, ROS1 and ALK fusions in lung cancer (2012) Nat Med Feb, 12. , doi, 10.1038/nm.2658. [Epub ahead of print]
Tong, Q., Xing, S., Jhiang, S.M., (1997) J Biol Chem, 272, pp. 9043-9047
Jhiang, S.M., The RET proto-oncogene in human cancers (2000) Oncogene, 19, pp. 5590-5597
Beausoleil, S.A., Jedrychowski, M., Schwartz, D., Elias, J.E., Villén, J., Large-scale characterization of HeLa cell nuclear phosphoproteins (2004) Proc Natl Acad Sci U S A, 101, pp. 12130-12135
Brill, L.M., Salomon, A.R., Ficarro, S.B., Mukherji, M., Stettler-Gill, M., Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry (2004) Anal Chem, 76, pp. 2763-2772
Grieco, M., Cerrato, A., Santoro, M., Fusco, A., Melillo, R.M., Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo (1994) Oncogene, 9, pp. 2531-2535
Celetti, A., Cerrato, A., Merolla, F., Vitagliano, D., Vecchio, G., H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: functional characterization (2004) Oncogene, 23, pp. 109-121
Merolla, F., Pentimalli, F., Pacelli, R., Vecchio, G., Fusco, A., Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (2007) Oncogene, 26, pp. 6167-6175
Leone, V., Mansueto, G., Pierantoni, G.M., Tornincasa, M., Merolla, F., CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1 (2010) Oncogene, 29, pp. 4341-4351
Hoeijmakers, J.H., Genome maintenance mechanisms for preventing cancer (2001) Nature, 411, pp. 366-374
Bartek, J., Lukas, J., DNA damage checkpoints: from initiation to recovery or adaptation (2007) Curr Opin Cell Biol, 19, pp. 238-245
Harper, J.W., Elledge, S.J., The DNA damage response: ten years after (2007) Mol Cell, 28, pp. 739-745
Kastan, M.B., Bartek, J., Cell-cycle checkpoints and cancer (2004) Nature, 432, pp. 312-316
Shiloh, Y., ATM and related protein kinases: safeguarding genome integrity (2003) Nat Rev Cancer, 3, pp. 155-156
Zhou, B.B., Elledge, S.J., The DNA damage response: putting checkpoints in perspective (2000) Nature, 408, pp. 433-439
Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S., Bonner, W.M., DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 (1998) J Biol Chem, 273, pp. 5858-5868
Fernandez-Capetillo, O., Lee, A., Nussenzweig, M., Nussenzweig, A., H2AX: the histone guardian of the genome (2004) DNA Repair (Amst), 3, pp. 959-967
Ewing, R.M., Chu, P., Elisma, F., Li, H., Taylor, P., Large-scale mapping of human protein-protein interactions by mass spectrometry (2007) Mol Syst Biol, 3, p. 89
Nakada, S., Chen, G.I., Gingras, A.C., Durocher, D., PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint (2008) EMBO Rep, 9, pp. 1012-1019
Lee, J.H., Paull, T.T., ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex (2005) Science, 308, pp. 551-554
Daniel, J.A., Pellegrini, M., Lee, J.H., Paull, T.T., Feigenbaum, L., Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo (2008) J Cell Biol, 183, pp. 777-783
Tsai, I.C., Hsieh, Y.J., Lyu, P.C., Yu, J.S., Anti-phosphopeptide antibody, P-STM as a novel tool for detecting mitotic phosphoproteins: identification of lamins A and C as two major targets (2005) J Cell Biochem, 94, pp. 967-981
Lazzaro, F., Giannattasio, M., Puddu, F., Granata, M., Pellicioli, A., Checkpoint mechanisms at the intersection between DNA damage and repair (2009) DNA Repair (Amst), 8, pp. 1055-1067
Speit, G., Hartmann, A., The contribution of excision repair to the DNA-effects seen in the alkaline single cell gel test (comet assay) (1995) Mutagenesis, 10, pp. 555-559
DiBiase, S.J., Guan, J., Curran Jr., W.J., Iliakis, G., Repair of DNA double- strand breaks and radiosensitivity to killing in an isogenic group of p53 mutant cell lines (1999) Int. J. Radiat. Oncol. Biol. Phys, 45, pp. 743-751
Mao Zhiyong, Bozzella, M., Seluanov, A., Gorbunova, V., Comparison of nonhomologous end joining and homologous recombination in human cells (2008) DNA Repair (Amst), 10, pp. 1765-1771
Cohen, P.T., Philp, A., Vázquez-Martin, C., Protein phosphatase 4-from obscurity to vital functions (2005) FEBS Lett, 579, p. 3278
Chowdhury, D., Xu, X., Zhong, X., Ahmed, F., Zhong, J., A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication (2008) Mol Cell, 31, pp. 33-46
Zhou, G., Boomer, J.S., Tan, T.H., Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1 (2004) J Biol Chem, 279, pp. 49551-49561
Tung, H.Y., Alemany, S., Cohen, P., The protein phosphatases involved in cellular regulation. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle (1985) Eur J Biochem, 148, pp. 253-263
Jossart, G.H., O'Brien, B., Cheng, J.F., Tong, Q., Jhiang, S.M., (1996) Cytogenetics and Cell Genetics, 75, pp. 254-257
Chen, G.I., Tisayakorn, S., Jorgensen, C., D'Ambrosio, L.M., Goudreault, M., PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 (2008) J Biol Chem, 283, pp. 29273-29284
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Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage
CCDC6 was originally identified in chimeric genes caused by chromosomal translocation involving the RET proto-oncogene in some thryoid tumors mostly upon ionizing radiation exposure. Recognised as a pro-apoptotic phosphoprotein that negatively regulates CREB1-dependent transcription, CCDC6 is an ATM substrate that is responsive to genotoxic stress. Here we report that following genotoxic stress, loss or inactivation of CCDC6 in cancers that carry the CCDC6 fusion, accelerates the dephosphorylation of pH2AX S139, resulting in defective G2 arrest and premature mitotic entry. Moreover, we show that CCDC6 depleted cells appear to repair DNA damaged in a shorter time compared to controls, based on reporter assays in cells. High-troughput proteomic screening predicted the interaction between the CCDC6 gene product and the catalytic subunit of Serin-Threonin Protein Phosphatase 4 (PP4c) recently identified as the evolutionarily conserved pH2AX S139 phosphatase that is activated upon DNA Damage. We describe the interaction between CCDC6 and PP4c and we report the modulation of PP4c enzymatic activity in CCDC6 depleted cells. We discuss the functional significance of CCDC6-PP4c interactions and hypothesize that CCDC6 may act in the DNA Damage Response by negatively modulating PP4c activity. Overall, our data suggest that in primary tumours the loss of CCDC6 function could influence genome stability and thereby contribute to carcinogenesis.
CCDC6 was originally identified in chimeric genes caused by chromosomal translocation involving the RET proto-oncogene in some thryoid tumors mostly upon ionizing radiation exposure. Recognised as a pro-apoptotic phosphoprotein that negatively regulates CREB1-dependent transcription, CCDC6 is an ATM substrate that is responsive to genotoxic stress. Here we report that following genotoxic stress, loss or inactivation of CCDC6 in cancers that carry the CCDC6 fusion, accelerates the dephosphorylation of pH2AX S139, resulting in defective G2 arrest and premature mitotic entry. Moreover, we show that CCDC6 depleted cells appear to repair DNA damaged in a shorter time compared to controls, based on reporter assays in cells. High-troughput proteomic screening predicted the interaction between the CCDC6 gene product and the catalytic subunit of Serin-Threonin Protein Phosphatase 4 (PP4c) recently identified as the evolutionarily conserved pH2AX S139 phosphatase that is activated upon DNA Damage. We describe the interaction between CCDC6 and PP4c and we report the modulation of PP4c enzymatic activity in CCDC6 depleted cells. We discuss the functional significance of CCDC6-PP4c interactions and hypothesize that CCDC6 may act in the DNA Damage Response by negatively modulating PP4c activity. Overall, our data suggest that in primary tumours the loss of CCDC6 function could influence genome stability and thereby contribute to carcinogenesis.
Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage
| ▼ Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors |
| ▼ Analysis of Sam domain druggability through computational and experimental studies |
Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage
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Impact Factor: 4.104
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Pedone E, Ren B, Ladenstein R, Rossi M, Bartolucci S
* Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus - A member of a novel protein family related to protein disulfide-isomerase (390 views)
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Impact Factor: 3.26
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Mainenti PP, D'Agostino L, Soscia E, Romano M, Salvatore M
* Hepatic and splenic amyloidosis: Dual-phase spiral CT findings (347 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Sep; 28(5): 688-690.
Impact Factor: 0.996
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Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (372 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
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Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (265 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
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Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (352 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
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Vitagliano L, Masullo M, Sica F, Zagari A, Bocchini V
* The crystal structure of Sulfolobus solfataricus elongation factor 1α in complex with GDP reveals novel features in nucleotide binding and exchange (452 views)
Embo J (ISSN: 0261-4189, 0261-4189linking), 2001 Oct 1; 20(19): 5305-5311.
Impact Factor: 12.459
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Mansi L, Rambaldi PF, Cuccurullo V, Pecori B, Quarantelli M, Fallanca F, Del Vecchio E
Diagnostic and prognostic role of 99mTc-Tetrofosmin in breast cancer (297 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1997 Sep; 41(3): 239-250.
Impact Factor: 2.125
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Mainenti PP, Petrelli G, Lamanda R, Amalfi G, Castiglione F
Primary systemic amyloidosis with giant hepatomegaly and a swiftly progressive course (255 views)
J Clin Gastroenterol (ISSN: 0192-0790), 1997 Apr; 24(3): 173-175.
Impact Factor: 0.936
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Oliva A, Marrone G, Della Ragione F, Riccio V, Palumbo R, Rossano F, Zappia V
Isolation and characterization of human embryonic osteoblasts (441 views)
Calcif Tissue Int (ISSN: 0171-967xprint, 0171-967xlinking), 1992 Nov; 51(5): 356-362.
Impact Factor: 2.364
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* The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function (34 views) (PDF 12 views)
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Impact Factor: 5.712
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Mercurio FA, Pirone L, Di Natale C, Marasco D, Pedone EM, Leone M
* Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2 (327 views)
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Ferrucci V, De Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M
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Caraci F, Nicoletti F, Copani A
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Mercurio FA, Costantini S, Di Natale C, Pirone L, Guariniello S, Scognamiglio PL, Marasco D, Pedone EM, Leone M
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Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
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Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M
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Olgiati S, De Rosa A, Quadri M, Criscuolo C, Breedveld GJ, Picillo M, Pappata S, Quarantelli M, Barone P, De Michele G, Bonifati V
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Impact Factor: 2.884
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Ciccarelli M, Rusciano MR, Sorriento D, Basilicata MF, Santulli G, Campiglia P, Bertamino A, De Luca N, Trimarco B, Iaccarino G, Illario M
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Cell Signal (ISSN: 0898-6568), 2014; 26(10): 2167-2174.
Impact Factor: 4.315
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Pedicini P, Fiorentino A, Improta G, Nappi A, Salvatore M, Storto G
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Impact Factor: 1.6
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Del Giudice I, Limauro D, Pedone E, Bartolucci S, Fiorentino G
* A novel arsenate reductase from the bacterium Thermus thermophilus HB27: Its role in arsenic detoxification (420 views)
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Impact Factor: 3.191
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
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Impact Factor: 4.907
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Bartolucci S, Contursi P, Fiorentino G, Limauro D, Pedone E
* Responding to toxic compounds: a genomic and functional overview of Archaea (702 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2013 Jan 1; 18: 165-189.
Impact Factor: 4.249
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (465 views)
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Impact Factor: 3.377
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Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
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Impact Factor: 2.338
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
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Impact Factor: 1.156
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Santoro L, Breedveld GJ, Manganelli F, Iodice R, Pisciotta C, Nolano M, Punzo F, Quarantelli M, Pappata S, Di Fonzo A, Oostra BA, Bonifati V
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Impact Factor: 3.354
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Barile E, Leone M, Barile E, Dahl R, Pellecchia M
* Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH (2177 views)
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Impact Factor: 2.282
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Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M
* NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH (519 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2010 Jul; 76(1): 10-16.
Impact Factor: 2.527
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1115 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Farina AR, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, Romanelli A, Pedone C, Gulino A, Mackay AR
* The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability (358 views)
Mol Cell Biol (ISSN: 1098-5549, 0270-7306), 2009 Sep 1; 29(17): 4812-4830.
Impact Factor: 6.057
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Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
* Bone mineral density in children, adolescents, and young adults with epilepsy (372 views)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
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Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (307 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
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Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (448 views)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (459 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
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Rendina D, De Filippo G, Viceconti R, Soscia E, Sirignano C, Salvatore M, Della Monica M, Scarano G, Mossetti G
* Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis (476 views)
Scand J Rheumatol (ISSN: 0300-9742), 2008 May; 37(3): 225-229.
Impact Factor: 2.345
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Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
* Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (360 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
Impact Factor: 2.531
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De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (472 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
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Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L
* The role of membrane glycoprotein plasma cell antigen 1 ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (874 views)
Endocrine Reviews (ISSN: 0163-769x), 2008 Feb; 29(1): 62-75.
Impact Factor: 18.562
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
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Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Pedone E, Saviano M, Bartolucci S, Rossi M, Ausili A, Scire A, Bertoli E, Tanfani F
* Temperature-, SDS-, and pH-induced conformational changes in protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: A dynamic simulation and fourier transform infrared spectroscopic study (318 views)
J Proteome Res (ISSN: 1535-3893), 2005 Nov; 4(6): 1972-1980.
Impact Factor: 6.901
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (478 views)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
View Export to BibTeX Export to EndNote
Pedone E, Ren B, Ladenstein R, Rossi M, Bartolucci S
* Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus - A member of a novel protein family related to protein disulfide-isomerase (390 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 Sep; 271(16): 3437-3448.
Impact Factor: 3.26
View Export to BibTeX Export to EndNote
Mainenti PP, D'Agostino L, Soscia E, Romano M, Salvatore M
* Hepatic and splenic amyloidosis: Dual-phase spiral CT findings (347 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Sep; 28(5): 688-690.
Impact Factor: 0.996
View Export to BibTeX Export to EndNote
Borgatti M, Romanelli A, Saviano M, Pedone C, Lampronti I, Breda L, Nastruzzi C, Bianchi N, Mischiati C, Gambari R
* Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum (372 views)
Oncology Research (ISSN: 0965-0407), 2003; 13(5): 279-287.
Impact Factor: 1.794
View Export to BibTeX Export to EndNote
Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC
* Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner (265 views)
Life Sci (ISSN: 0024-3205), 2002; 71(11): 1293-1301.
Impact Factor: 1.824
View Export to BibTeX Export to EndNote
Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (352 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
View Export to BibTeX Export to EndNote
Vitagliano L, Masullo M, Sica F, Zagari A, Bocchini V
* The crystal structure of Sulfolobus solfataricus elongation factor 1α in complex with GDP reveals novel features in nucleotide binding and exchange (452 views)
Embo J (ISSN: 0261-4189, 0261-4189linking), 2001 Oct 1; 20(19): 5305-5311.
Impact Factor: 12.459
View Export to BibTeX Export to EndNote
Mansi L, Rambaldi PF, Cuccurullo V, Pecori B, Quarantelli M, Fallanca F, Del Vecchio E
Diagnostic and prognostic role of 99mTc-Tetrofosmin in breast cancer (297 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1997 Sep; 41(3): 239-250.
Impact Factor: 2.125
View Export to BibTeX Export to EndNote
Mainenti PP, Petrelli G, Lamanda R, Amalfi G, Castiglione F
Primary systemic amyloidosis with giant hepatomegaly and a swiftly progressive course (255 views)
J Clin Gastroenterol (ISSN: 0192-0790), 1997 Apr; 24(3): 173-175.
Impact Factor: 0.936
View Export to BibTeX Export to EndNote
Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
Oliva A, Marrone G, Della Ragione F, Riccio V, Palumbo R, Rossano F, Zappia V
Isolation and characterization of human embryonic osteoblasts (441 views)
Calcif Tissue Int (ISSN: 0171-967xprint, 0171-967xlinking), 1992 Nov; 51(5): 356-362.
Impact Factor: 2.364
View Export to BibTeX Export to EndNote
44 Records (44 excluding Abstracts).
Total impact factor: 184.591 (184.591 excluding Abstracts).
Total 5 year impact factor: 183.882 (183.882 excluding Abstracts).
Total impact factor: 184.591 (184.591 excluding Abstracts).
Total 5 year impact factor: 183.882 (183.882 excluding Abstracts).
361 views. Last view on Wednesday 08 March 2023, 21:14:05
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