Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein(483 views) Jószai V, Turi I, Kállay C, Pappalardo G, Di Natale G, Rizzarelli E, Sóvágó I
University of Debrecen, Department of Inorganic and Analytical Chemistry, H-4010 Debrecen, Hungary.
CNR, Institute of Biostructures and Bioimaging, Catania, 95125 Catania, Italy
University of Catania, Department of Chemical Sciences, 95125 Catania, Italy
Garnett, A.P., Viles, J.H., (2003) J. Biol. Chem., 278, pp. 6795-6802
Chattopadhyay, M., Walter, E.D., Newell, D.J., Jackson, P.J., Aronoff-Spencer, E., Peisach, J., Gerfen, G.J., Millhauser, G.L., (2005) J. Am. Chem. Soc., 127, pp. 12647-12656
Walter, E.D., Chattopadhyay, M., Millhauser, G.L., (2006) Biochemistry, 45, pp. 13083-13092
Valensin, D., Luczkowski, M., Mancini, F.M., Legowska, A., Gaggelli, E., Valensin, G., Rolka, K., Kozlowski, H., (2004) Dalton Trans., pp. 1284-1293
Bonomo, R.P., Impellizzeri, G., Pappalardo, G., Rizzarelli, E., Tabbi, G., (2000) Chem. Eur. J., 6, pp. 4195-4202
Bonomo, R.P., Di Natale, G., Rizzarelli, E., Tabbi, G., Vagliasindi, L.I., (2009) Dalton Trans., pp. 2637-2646
Jones, C.E., Abdelraheim, S.R., Brown, D.R., Viles, J.H., (2004) J. Biol. Chem., 279, pp. 32018-32027
Gralka, E., Valensin, D., Gajda, K., Bacco, D., Szyrwiel, L., Remelli, M., Valensin, G., Kozlowski, H., (2009) Mol. Biosyst., 5, pp. 497-510
Jones, C.E., Klewpatinond, M., Abdelraheim, S.R., Brown, D.R., Viles, J.H., (2005) J. Mol. Biol., 346, pp. 1393-1407
Belosi, B., Gaggelli, E., Guerrini, R., Kozlowski, H., Luczkowski, M., Mancini, F.M., Remelli, M., Valensin, G., (2004) ChemBioChem, 5, pp. 349-359
Berti, F., Gaggelli, E., Guerrini, R., Janicka, A., Kozlowski, H., Legowska, A., Miecznikowska, H., Valensin, G., (2007) Chem. Eur. J., 13, pp. 1991-2001
Jószai, V., Nagy, Z., Osz, K., Sanna, D., Di Natale, G., La Mendola, D., Pappalardo, G., Sóvágó, I., (2006) J. Inorg. Biochem., 100, pp. 1399-1409
Di Natale, G., Grasso, G., Impellizzeri, G., La Mendola, D., Micera, G., Mihala, N., Nagy, Z., Sóvágó, I., (2005) Inorg. Chem., 44, pp. 7214-7225
Grasso, D., Grasso, G., Guantieri, V., Impellizzeri, G., La Rosa, C., Milardi, D., Micera, G., Sóvá gó, I., (2006) Chem. Eur. J., 12, pp. 537-547
Osz, K., Nagy, Z., Pappalardo, G., Di Natale, G., Sanna, D., Micera, G., Rizzarelli, E., Sóvágó, I., (2007) Chem. Eur. J., 13, pp. 7129-7143
Di Natale, G., Osz, K., Nagy, Z., Sanna, D., Micera, G., Pappalardo, G., Sóvágó, I., Rizzarelli, E., (2009) Inorg. Chem., 48, pp. 4239-4250
Sóvágó, I., Osz, K., (2006) Dalton Trans., pp. 3841-3854
Klewpatinond, M., Viles, J.H., (2007) FEBS Lett., 581, pp. 1430-1434
Turi, I., Kállay, C., Szikszai, D., Pappalardo, G., Di Natale, G., De Bona, P., Rizzarelli, E., Sóvágó, I., (2010) J. Inorg. Biochem., 104, pp. 885-891
Walter, E.D., Stevens, D.J., Visconte, M.P., Millhauser, G., (2007) J. Am. Chem. Soc., 129, pp. 15440-15441
Józsa, É., Osz, K., Kállay, C., De Bona, P., Damante, C.A., Pappalardo, G., Rizzarelli, E., Sóvágó, I., (2010) Dalton Trans., 39, pp. 7046-7053
Damante, C.A., Osz, K., Nagy, Z., Grasso, G., Pappalardo, G., Rizzarelli, E., Sóvágó, I., (2011) Inorg. Chem., 50, pp. 5342-5350
Zékány, L., Nagypál, I., (1985) Computational Methods for the Determination of Stability Constants, pp. 291-355. , D.J. Leggett, Plenum Press New York
Gans, P., Sabatini, A., Vacca, A., (1996) Talanta, 43, pp. 1739-1753
Kállay, C., Várnagy, K., Malandrinos, G., Hadjiliadis, N., Sanna, D., Sóvágó, I., (2009) Inorg. Chim. Acta, 362, pp. 935-945
Kállay, C., Osz, K., Dávid, A., Valastyán, Z., Malandrinos, G., Hadjiliadis, N., Sóvágó, I., (2007) Dalton Trans., pp. 4040-4047
Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein
Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of four peptide fragments of human prion protein have been studied by potentiometric, UV-vis and circular dichroism spectroscopic techniques. One peptide contained three histidyl residues: HuPrP(84-114) with H85 inside and H96, H111 outside the octarepeat domain. The other three peptides contained two histidyl residues; H96 and H111 for HuPrP(91-115) and HuPrP(84-114)H85A while HuPrP(84-114)H96A contained the histidyl residues at positions 85 and 111. It was found that both histidines of the latter peptides can simultaneously bind copper(II) and nickel(II) ions and dinuclear mixed metal complexes can exist in slightly alkaline solution. One molecule of the peptide with three histidyl residues can bind two copper(II) and one nickel(II) ions. H85 and H111 were identified as the major copper(II) and H96 as the preferred nickel(II) binding sites in mixed metal species. The studies on the zinc(II)-PrP peptide binary systems revealed that zinc(II) ions can coordinate to the 31-mer PrP peptide fragments in the form of macrochelates with two or three coordinated imidazol-nitrogens but the low stability of these complexes cannot prevent the hydrolysis of the metal ion in slightly alkaline solution. These data provide further support for the outstanding affinity of copper(II) ions towards the peptide fragments of prion protein but the binding of nickel(II) can significantly modify the distribution of copper(II) among the available metal binding sites. Copyright 2012 Elsevier Inc. All rights reserved.
Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein
No results.
Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein
Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I * Copper(II) complexes of rat amylin fragments(360 views) Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721. Impact Factor:3.838 ViewExport to BibTeXExport to EndNote