Reduced Striatal [123I]FP-CIT Binding in SCA2 Patients without Parkinsonism(425 views) Varrone A, Salvatore E, De Michele G, Barone P, Sansone V, Pellecchia MT, Castaldo I, Coppola G, Brunetti A, Salvatore M, Pappata S, Filla A
Biostruct. and Bioimaging Institute, National Research Council, Naples, Italy
Department of Neurological Sciences, University of Napoli Federico II, Naples, Italy
Dept. of Biomorphol. and Funct. Sci., University of Napoli Federico II, Naples, Italy
Dept. of Cell./Molec. Biol./Pathol., University of Napoli Federico II, Naples, Italy
Biostructure and Bioimaging Institute, National Research Council, Via S. Pansini 5, 80131 Naples, Italy. andrea.varrone@ibb.cnr.it
Dept. of Cell. /Molec. Biol. /Pathol., University of Napoli Federico II, Naples, Italy
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Cancel, G., D rr, A., Didierjean, O., Molecular and clinical correlations in spinocerebellar ataxia 2: A study of 32 families (1997) Hum Mol Genet, 6, pp. 709-715
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Reduced Striatal [123I]FP-CIT Binding in SCA2 Patients without Parkinsonism
Degeneration of substantia nigra has been described in spinocerebellar ataxia type 2 (SCA2). In this study, dopamine transporter (DAT) density with [123 I] FP-CIT SPECT was studied in six SCA2 patients with no parkinsonian signs, six Parkinson's disease (PD) patients, and six controls. Marked striatal DAT loss was found in both SCA2 and PD patients. However, a more severe reduction in the caudate and a higher putamen to caudate ratio distinguished SCA2 from PD patients, suggesting a more uniform nigrostriatal impairment in SCA2. Striatal DAT density of SCA2 patients correlated with the severity of cerebellar ataxia
Reduced Striatal [123I]FP-CIT Binding in SCA2 Patients without Parkinsonism
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Reduced Striatal [123I]FP-CIT Binding in SCA2 Patients without Parkinsonism
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