Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas(378 views) Tedeschi E, Soricelli A, Brunetti A, Romano M, Bucciero A, Iaconetta G, Alfieri A, Postiglione A, Salvatore M
Affiliations: Dipto. di Diagnostica per Immagini, Centro CNR per la Medicina Nucleare, Napoli, Italy
Istituto di Neurochirurgia, Universitè Federico II, Napoli, Italy
Dipartimento di Clinica Medica, Universitè Federico II, Napoli, Italy
Parco Comola-Ricci, 118, I-80122 Napoli, Italy
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Kaplan, R. D., Coons, S., Drayer, B. P., Bird, C. R., Johnson, P. C., MR characteristics of meningioma subtypes at 1. 5 Tesla (1992) J Comput Assist Tomogr, 16, pp. 366-371
Black, P. M., Meningiomas (1993) Neurosurgery, 32, pp. 643-657
Marks, S. M., Whitwell, H. L., Lye, R. H., Recurrence of meningiomas after operation (1986) Surg Neurol, 25, pp. 436-440
Kasarov, L. B., Friedman, H., Enhanced Na+-K+-activated adenosine triphosphatase activity in transformed fibroblasts (1974) Cancer Res, 34, pp. 1862-1865
Abdel-Dayem, H. M., Scotti, A. M., Macupinlac, H. A., El-Gazzar, A. H., Role of 201thallium-chloride and 99mTc-sestamibi in tumor imaging (1994) Nuclear Medicine Annual, pp. 181-234. , Freeman LM, ed. New York: Raven Press
Carvalho, P. A., Schwartz, R. B., Alexander III, E., Garada, B. M., Zimmermann, R. E., Loeffler, J. S., Holman, B. L., Detection of recurrent gliomas with quantitative thallium-201/technetium-99m HMPAO single photon emission computerized tomography (1992) J Neurosurg, 77, pp. 565-570
Black, K. L., Hawkins, R. A., Kim, K. T., Becker, D. P., Lerner, C., Marciano, D., Use of thallium-201 SPET to quamitate malignancy grade of gliomas (1989) J Neurosurg, 71, pp. 342-346
Dierckx, R. A., Martin, J. J., Dobbeleir, A., Crols, A., Neetens, I., De Deyn, D. D., Sensitivity and specificity of thallium-201 single photon emission tomography in the functional detection and differential diagnosis of brain tumours (1994) Eur J Nucl Med, 21, pp. 621-633
Slizofski, W. J., Krishna, L., Katsetos, C. D., Black, P., Miyamoto, C., Brown, S. J., Vender, J., Dadparvar, S., Thallium imaging for brain tumors with results measured by a semiquantitative index and correlated with histopathology (1994) Cancer, 74, pp. 3190-3197
Russell, D. S., Rubinstein, L. J., (1989) Pathology of Tumours of Nervous System, pp. 441-489. , Baltimore: Williams & Wilkins
Holman, L. B., Carvalho, P. A., Zimmerman, R. E., Johnson, K. A., Tumeh, S. S., Smith, A. P., Genna, S., Brain perfusion SPECT studies using an annular single crystal camera: Initial clinical experience (1990) J Nucl Med, 31, pp. 1456-1461
Biersack, H. J., Grunwald, F., Kropp, J., Single photon emission computed tomography imaging of brain tumours (1991) Semin Nucl Med, 21, pp. 2-10
Langen, K. J., Roosen, N., Herzog, H., Kuwert, T., Kiwit, J. C. W., Bock, W. J., Feinendegen, L. E., Investigations of brain tumours with 99m-Tc-HMPAO SPECT (1989) Nucl Med Commun, 10, pp. 325-334
Kim, K., Black, K. L., Marciano, D., Mazziotta, J. C., Guze, B. H., Grafton, S., Hawkins, R. A., Becker, D. P., Thallium-201 SPECT imaging of brain tumours: Methods and results (1990) J Nucl Med, 31, pp. 965-969
Slosman, D. O., Pugin, J., Lack of correlation between tritiateddeoxyglucose, thallium-201 and technetium-99m-MIBI cell incorporation under various cell stresses (1994) J Nucl Med, 35, pp. 120-126
Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas
To evaluate the possibility of preoperatively obtaining an index of aggressiveness for intracranial meningiomas, we prospectively studied 22 patients with computed tomographic or magnetic resonance imaging evidence of meningeal tumour, using single-photon emission tomography (SPET) of the brain and thallium-201 (201T1). On a brain-dedicated SPET scanner, a rapid acquisition protocol with early, short scans was started simultaneously with the intravenous administration of 111 NIBq 201T1, covering the initial intratumoral distribution of the tracer. Twenty minutes post injection, a delayed SPET scan was also obtained. On the reconstructed and attenuation-corrected images we calculated the 201T1 concentration in tumour and normal contralateral brain tissue, and compared intratumoral tracer concentration in the initial and the final part of the rapid acquisition protocol. Benign and malignant meningiomas were classified as such based on histological examination. In malignant lesions, the ratio of the 201T1 concentration at 2-4 min post injection to that at 14-16 min was found to be significantly higher than in non-aggressive neoplasms (mean±1 SD: 1.14±0.31 and 0.56±0.13, respectively, P <0.01). Conversely, in the delayed scan, most lesions showed high tracer concentration, and the two groups could not be distinguished. In addition, three recurrent meningiomas displayed the same imaging behaviour as the malignant group, i.e, had similar 201T1 concentration values at 2-3 and at 14-16 min. Our findings suggest that the comparative assessment of intratumoral 201T1 concentration at 2-4 and at 14-16 min post injection could provide a fast, simple method to differentiate preoperatively intracranial meningiomas with different biological behaviour.
Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(726 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote