Neuronorm is a potent and water soluble neurokinin A receptor antagonist(513 views) Lombardi A, D'Agostino B, Filippelli A, Pedone C, Matera MG, Falciani M, De Rosa M, Rossi F, Pavone V
Keywords: Men 10627, Neurokinin 2 Receptor Antagonist, Neuronorm, Substance P, Tachykinin, Unclassified Drug, Animal Tissue, Article, Controlled Study, Drug Potency, Drug Solubility, Drug Synthesis, Guinea Pig, Nonhuman, Peptide Synthesis, Proton Nuclear Magnetic Resonance, Respiratory Tract Inflammation, Smooth Muscle Contraction, Structure Analysis, Trachea, Vas Deferens, Cyclic,
Affiliations: Ctro. Interuniveristario di R., Universita di Napoli Federico II, via Mezzocannone 4, 80134 Napoli, Italy
Ist. di Farmacologia e Tossicologia, Seconda Università di Napoli, via Costantinopoli 16, 80131 Napoli, Italy
Ist. di Biochim. delle Macromolecule, Seconda Università di Napoli, via Costantinopoli 16, 80131 Napoli, Italy
References: Not available.
Neuronorm is a potent and water soluble neurokinin A receptor antagonist
We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN 10627.
Neuronorm is a potent and water soluble neurokinin A receptor antagonist
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Neuronorm is a potent and water soluble neurokinin A receptor antagonist
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(433 views) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 ViewExport to BibTeXExport to EndNote