Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: Comparison with enalapril(290 views) Cuocolo A, Storto G, Izzo R, Iovino GL, Damiano M, Bertocchi F, Mann J, Trimarco B
Journal Of Hypertension (ISSN: 0263-6352), 1999 Dec; 17(12): 1759-1766.
Affiliations: Nucl. Med. Ctr. Natl. Cncl. of Res., Dept. Biomorphological Funct. Sci., University Federico II, Napoli, Italy
Dept. Clin. Med. Cardiovasc. Sci., University Federico II, Napoli, Italy
IRCCS Neuromed, Pozzilli, Italy
Novartis Pharma, Basle, Switzerland
Inst. Int. Med., Cardiol. Heart S., Università Federico II, Via Pansini 5, 80131 Napoli, Italy
References: Gaash, W.H., Blaunstein, A.S., Andrias, C.W., Donahue, R.P., Avitall, B., Myocardial relaxation. II. Hemodynamic determinations of rate of left ventricular isovolumic pressure decline (1980) Am J Physiol, 239, pp. H1-H
Devoreux, R.B., Left ventricular diastolic dysfunction: Early diastolic relaxation and late diastolic compliance (1989) J Am Coll Cardiol, 13, pp. 337-339
Philips, R.A., Goldman, M.E., Ardeljan, M.A., Eison, H.B., Buyan, Y.U., Krakoff, L.R., Determinants of abnormal left ventricular filling in early hypertension (1989) J Am Coll Cardiol, 14, pp. 979-985
Choong, C.Y., Horrmann, H.C., Weymann, A.E., Fifer, M.A., Preload dependence of Doppler-derived indexes of left ventricular diastolic function in humans (1987) J Am Coll Cardiol, 10, pp. 800-808
Pace, L., Cuocolo, A., Nappi, A., Nicolai, E., Trimarco, B., Salvatore, M., Accuracy and repeatability of left ventricular systolic and diastolic function measurements using an ambulatory radionuclide monitor (1992) Eur J Nucl Med, 19, pp. 800-806
Breisblatt, W.M., Wolf, C.J., McElhinny, B., Salerni, R., Smith, V.E., Comparison of ambulatory left ventricular ejection fraction and BP in systemic hypertension in patients with and without increased left ventricular hypertrophy (1993) Am Heart J, 125, pp. 1710-1716
Volpe, M., Rao, M.A.E., Cuocolo, A., Russo, R., Nappi, A., Mele, A.F., Radionuclide monitoring of cardiac adaptations to volume loading in patients with dilated cardiomyopathy and mild heart failure. Effects of angiotensin-converting enzyme inhibition (1995) Circulation, 92, pp. 2511-2518
Zusman, R.M., Christensen, D.M., Higgins, J., Boucher, C.A., Effects of fosinopril on cardiac function in patients with hypertension. Radionuclide assessment of left ventricular systolic and diastolic performance (1992) Am J Hypertens, 5, pp. 219-223
Goa, K.L., Wagstaff, A.J., Losartan potassium
a review of its pharmacology, clinical efficacy and tolerability in the management of hypertension (1996) Drugs, 51, pp. 820-845
Holwerda, N.J., Fogari, R., Angeli, P., Porcellati, C., Herreng, C., Oddou-Stock, P., Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: Efficacy and safety compared to placebo and onalapril (1996) J Hypertens, 14, pp. 1147-1151
Dovereux, R.B., Alonso, D.R., Lutas, E.M., Gottlieb, G.J., Campo, E., Sachs, I., Echocardiographic assessment of left ventricular hypertrophy
comparison to necropsy findings (1986) Am J Cardiol, 57, pp. 450-458
Massardo, T., Gal, R.A., Grenier, R.P., Schmidt, D.H., Port, S.C., Left ventricular volume calculation using a count-based ratio method applied to multigated radionuclide angiography (1990) J Nucl Med, 31, pp. 450-456
Imbriaco, M., Cuocolo, A., Pace, L., Nappi, A., Nicolai, E., Maurea, S., Repeatability of haemodynamic responses to cardiac stimulations by ambulatory monitoring of left ventricular function (1993) J Nucl Biol Med, 37, pp. 238-244
Morisco, C., Cuocolo, A., Romano, M., Nappi, A., Iaccarino, G., Volpe, M., Influence of digitalis on left ventricular functional response to exercise in congestive heart failure (1996) Am J Cardiol, 77, pp. 480-485
Bonow, R.O., Udelson, J.E., Left ventricular diastolic dysfunction as a cause of congestive heart failure (1992) Ann Intern Med, 117, pp. 502-510
Brutsaert, D.L., Sys, S.U., Relaxation and diastole of the heart (1989) Physiol Rev, 69, pp. 1228-1315
Hirsch, A.T., Tolsness, C.E., Smith, A.D., Schunkert, H., Ingelfinger, J.R., Dzau, U.J., Differential effects of captopril and enalapril on tissue renin-angiotensin system in experimental heart failure (1992) Circulation, 86, pp. 1566-1574
Re, R., The myocardial intracellular renin-angiotensin system (1987) Am J Cardiol, 59, pp. 56A-58A
Grinstead, W.C., Young, J.B., The myocardial renin-angiotensin system: Existence, importance and clinical implications (1992) Am Heart J, 123, pp. 1039-1045
Brilla, G.C., Scheer, C., Rupp, H., Renin-angiotensin system and myocardial collagen matrix: Modulation of cardiac fibroblast function by angiotensin II type I receptor antagonism (1997) J Hypertens, 15 (6 SUPPL.), pp. 513-519
Cuocolo, A., Sax, F.L., Brush, J.E., Maron, B.J., Bacharach, S.L., Bonow, R.O., Left ventricular hypertrophy and impaired diastolic filling in essential hypertension (1990) Circulation, 81, pp. 978-986
Covi, G., Sheiban, I., Gelmini, G., Arcaro, G., Tonni, S., Bolner, A., Left ventricular diastolic function during adrenergic stress in essential hypertension: Acute and chronic effects of ACE inhibition (1996) Cardiovasc Drugs Ther, 10, pp. 321-329
Inouye, I., Massie, B., Loge, D., Abnormal left ventricular filling: An early finding in mild systemic hypertension (1984) Am J Cardiol, 53, pp. 120-126
Flesch, M., Schiffer, F., Zolk, O., Pinto, Y., Stasch, J.P., Knorr, A., Angiotensin receptor antagonism and angiotensin converting enzyme inhibition improve diastolic dysfunction and Ca++ ATPase expression in the sarcoplasmic reticulum in hypertensive cardiomyopathy (1997) J Hypertens, 15, pp. 1001-1009
Sagastagoitia, D., Morillas, M., Murga, N., Boveda, J., Molinaro, E., Rodriguez, E., Functional and organic components of diastolic dysfunction in hypertensive heart disease
Gaash, W. H., Blaunstein, A. S., Andrias, C. W., Donahue, R. P., Avitall, B., Myocardial relaxation. II. Hemodynamic determinations of rate of left ventricular isovolumic pressure decline (1980) Am J Physiol, 239, pp. H1-H
Devoreux, R. B., Left ventricular diastolic dysfunction: Early diastolic relaxation and late diastolic compliance (1989) J Am Coll Cardiol, 13, pp. 337-339
Philips, R. A., Goldman, M. E., Ardeljan, M. A., Eison, H. B., Buyan, Y. U., Krakoff, L. R., Determinants of abnormal left ventricular filling in early hypertension (1989) J Am Coll Cardiol, 14, pp. 979-985
Choong, C. Y., Horrmann, H. C., Weymann, A. E., Fifer, M. A., Preload dependence of Doppler-derived indexes of left ventricular diastolic function in humans (1987) J Am Coll Cardiol, 10, pp. 800-808
Breisblatt, W. M., Wolf, C. J., McElhinny, B., Salerni, R., Smith, V. E., Comparison of ambulatory left ventricular ejection fraction and BP in systemic hypertension in patients with and without increased left ventricular hypertrophy (1993) Am Heart J, 125, pp. 1710-1716
Volpe, M., Rao, M. A. E., Cuocolo, A., Russo, R., Nappi, A., Mele, A. F., Radionuclide monitoring of cardiac adaptations to volume loading in patients with dilated cardiomyopathy and mild heart failure. Effects of angiotensin-converting enzyme inhibition (1995) Circulation, 92, pp. 2511-2518
Zusman, R. M., Christensen, D. M., Higgins, J., Boucher, C. A., Effects of fosinopril on cardiac function in patients with hypertension. Radionuclide assessment of left ventricular systolic and diastolic performance (1992) Am J Hypertens, 5, pp. 219-223
Goa, K. L., Wagstaff, A. J., Losartan potassium
Holwerda, N. J., Fogari, R., Angeli, P., Porcellati, C., Herreng, C., Oddou-Stock, P., Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: Efficacy and safety compared to placebo and onalapril (1996) J Hypertens, 14, pp. 1147-1151
Dovereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., Echocardiographic assessment of left ventricular hypertrophy
Bonow, R. O., Udelson, J. E., Left ventricular diastolic dysfunction as a cause of congestive heart failure (1992) Ann Intern Med, 117, pp. 502-510
Brutsaert, D. L., Sys, S. U., Relaxation and diastole of the heart (1989) Physiol Rev, 69, pp. 1228-1315
Hirsch, A. T., Tolsness, C. E., Smith, A. D., Schunkert, H., Ingelfinger, J. R., Dzau, U. J., Differential effects of captopril and enalapril on tissue renin-angiotensin system in experimental heart failure (1992) Circulation, 86, pp. 1566-1574
Grinstead, W. C., Young, J. B., The myocardial renin-angiotensin system: Existence, importance and clinical implications (1992) Am Heart J, 123, pp. 1039-1045
Brilla, G. C., Scheer, C., Rupp, H., Renin-angiotensin system and myocardial collagen matrix: Modulation of cardiac fibroblast function by angiotensin II type I receptor antagonism (1997) J Hypertens, 15 (6 SUPPL.), pp. 513-519
Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: Comparison with enalapril
Objective. This study compares the effects of an AT1 angiotensin II receptor antagonist (valsartan) with those of an ACE inhibitor (enalapril) on left ventricular (LV) diastolic function in patients with mild or moderate essential hypertension and no evidence of LV hypertrophy at echocardiography. Methods. A total of 24 patients (16 men, mean age 47 ± 8 years) underwent radionuclide ambulatory monitoring (Vest) of LV function at rest and during upright bicycle exercise testing before and after two 4-week treatment periods with valsartan (80-160 mg/day orally) and enalapril (20-40 mg/day orally) according to a double-blind, crossover randomization scheme. Results. In the overall population no differences between the two treatments were found in LV peak filling rate (PFR) either at rest or at peak exercise. In a subgroup analysis it was found that baseline PFR was normal (= 2.5 EDV/sec) in 12 patients (subgroup A) and impaired (< 2.5 EDV/sec) in the remaining 12 (subgroup B). In both subgroups, valsartan and enalapril induced a significant and comparable reduction of systolic and diastolic blood pressure. In subgroup A, valsartan and enalapril did not induce significant changes in PFR. In subgroup B, valsartan increased PFR both at rest (from 2.0 ± 0.3 to 2.4 ± 0.3 EDV/sec, P < 0.01) and at peak exercise (from 4.1 ± 1.1 to 4.4 ± 1.0 EDV/s, P < 0.05), whereas enalapril did not change PFR either at rest (2.0 ± 0.4 EDV/s, P < 0.01 versus valsartan) or at peak exercise (3.7 ± 1.1 EDV/sec, P < 0.05 versus valsartan). Conclusions. Valsartan-induced renin-angiotensin system blockade is able to improve LV filling in patients with mild or moderate essential hypertension and impaired diastolic function. These findings support the hypothesis of a contribution of the renin-angiotensin system in the control of LV diastolic function in these patients.
Effects of valsartan on left ventricular diastolic function in patients with mild or moderate essential hypertension: Comparison with enalapril
Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G * Adrenergic Receptors(262 views) Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315. Impact Factor:0 ViewExport to BibTeXExport to EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(349 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote
Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G * The relationship between cerebral vascular disease and parkinsonism: The VADO study(496 views) Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780. Impact Factor:3.274 ViewExport to BibTeXExport to EndNote
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease(600 views) Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026. Impact Factor:0.913 ViewExport to BibTeXExport to EndNote