Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma (291 views)
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
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Paper type: Journal Article,
Impact factor: 1.6, 5-year impact factor: 1.379
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84886595505&partnerID=40&md5=714a83eb269f4e06a7f7aff5e3996526
Keywords: Accelerated Proliferation, Doubling Time, Pten Expression, Radiosensitivity, Phosphatidylinositol 3, 5 Trisphosphate 3 Phosphatase, Article, Cancer Radiotherapy, Controlled Study, Head And Neck Squamous Cell Carcinoma, Human, Postoperative Care, Postoperative Radiotherapy, Predictive Value, Protein Expression, Radiation Dose Fractionation, Algorithms, Cell Proliferation, Disease Progression, Follow-Up Studies, Head And Neck Neoplasms, Neoplasm Recurrence, Local, Postoperative Period, Prognosis, Pten Phosphohydrolase, Radiation Injuries, Tumor Markers, Biological,
Affiliations:
*** IBB - CNR ***
Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028 Rionero in Vulture, PZ, Italy
I.R.C.C.S. SDN Foundation, Naples, Italy
I. R. C. C. S. SDN Foundation, Naples, Italy
References:
Overgaard, J., Alsner, J., Eriksen, J., Horsman, M.R., Grau, C., Importance of overall treatment time for the response to radiotherapy in patients with squamous cell carcinoma of the head and neck (2000) Rays., 25, pp. 313-31
Overgaard, J., Hansen, H.S., Specht, L., Overgaard, M., Grau, C., Andersen, E., Bentzen, J., Evensen, J.F., Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial (2003) Lancet, 362 (9388), pp. 933-940. , DOI 10.1016/S0140-6736(03)14361-9
Hansen, O., Overgaard, J., Hansen, H.S., Overgaard, M., Hoyer, M., Jorgensen, K.E., Bastholt, L., Berthelsen, A., Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma: Dependency on tumor differentiation (1997) Radiotherapy and Oncology, 43 (1), pp. 47-51. , DOI 10.1016/S0167-8140(97)01904-X, PII S016781409701904X
Dassonville, O., Formento, J.L., Francoual, M., Ramaioli, A., Santini, J., Schneider, M., Demard, F., Milano, G., Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer (1993) Journal of Clinical Oncology, 11 (10), pp. 1873-1878
Eriksen, J.G., Steiniche, T., Askaa, J., Alsner, J., Overgaard, J., The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck (2004) International Journal of Radiation Oncology Biology Physics, 58 (2), pp. 561-566. , DOI 10.1016/j.ijrobp.2003.09.043
Bentzen, S.M., Atasoy, B.M., Daley, F.M., Dische, S., Richman, P.I., Saunders, M.I., Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial (2005) J Clin Oncol., 23, pp. 5560-5567
Suwinski, R., Jaworska, M., Nikiel, B., Grzegorz, W., Bankowska-Wozniak, M., Wojciech, M., Predicting the effect of accelerated fractionation in postoperative radiotherapy for head and neck cancer based on molecular marker profiles: Data from a randomized clinical trial (2010) Int J Radiat Oncol Biol Phys., 77, pp. 438-446
Chung, C.H., Zhang, Q., Hammond, E.M., Trotti III, A.M., Wang, H., Spencer, S., Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head and neck squamous cell carcinoma (2011) Int J Radiat Oncol Biol Phys., 81, pp. 331-338
Snietura, M., Jaworska, M., Mlynarczyk Liszka, J., Goraj-Zajac, A., Piglowski, W., Lange, D., PTEN as a prognostic and predictive marker in postoperative radiotherapy for squamous cell cancer of the head and neck (2012) PLoS One., 7, pp. e33396
Pedicini, P., Strigari, L., Benassi, M., Estimation of a self consistent set of radiobiological parameters from hypofractionated versus standard radiotherapy of prostate cancer (2013) Int J Radiat Oncol Biol Phys., , doi:10.1016/j.ijrobp. 2012.11.033
Pedicini, P., Nappi, A., Strigari, L., Alicia Jereczek-Fossa, B., Alterio, D., Cremonesi, M., Correlation between EGFR expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (2012) Radiat Oncol., 7, p. 143
Thames, H.D., Bentzen, S.M., Turesson, I., Overgaard, M., Van Den Bogaert, W., Time-dose factors in radiotherapy: A review of the human data (1990) Radiotherapy and Oncology, 19 (3), pp. 219-235
Bentzen, S.M., Johansen, L.V., Overgaard, J., Thames, H.D., Clinical radiobiology of squamous cell carcinoma of the oropharynx (1991) Int J Radiat Oncol Biol Phys., 20, pp. 1197-1206
Withers, H.R., Taylor, J.M.G., MacIejewski, B., The hazard of accelerated tumour clonogen repopulation during radiotherapy (1988) Acta Oncol., 27, pp. 131-146
Robertson, C., Robertson, A.G., Hendry, J.H., Roberts, S.A., Slevin, N.J., Duncan, W.B., MacDougall, R.H., Keane, T.J., Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four centers (1998) International Journal of Radiation Oncology Biology Physics, 40 (2), pp. 319-329. , DOI 10.1016/S0360-3016(97)00716-5, PII S0360301697007165
Thames Jr., H.D., Rozell, M.E., Tucker, S.L., Direct analysis of quantal radiation response data (1986) International Journal of Radiation Biology, 49 (6), pp. 999-1009
Collett, D., (1994) Modelling Survival Data-in Medical Research, , London (UK): Chapman and Hall
Barendsen, G.W., Dose fractionation, dose rate and isoeffect relationships for normal tissue responses (1982) Int J Radiat Oncol Biol Phys., 8, pp. 779-790
Hildebrandt, M.A., Lippman, S.M., Etzel, C.J., Kim, E., Lee, J.J., Khuri, F.R., Genetic variant in the PI3K/PTEN/AKT/mTOR pathway predict head and neck cancer patient second primary tumor/recurrence risk and response to retinoid chemoprevention (2012) Clin Cancer Res., 18, pp. 3705-3713
Salmena, L., Carracedo, A., Pandolfi, P.P., Tenets of PTEN Tumor Suppression (2008) Cell, 133 (3), pp. 403-414. , DOI 10.1016/j.cell.2008.04.013, PII S0092867408005047
Wang, X., Jiang, X., PTEN: A default gate-keeping tumor suppressor with a versatile tail (2008) Cell Res., 18, pp. 807-816
Dittmann, K., Mayer, C., Rodemann, H.-P., Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity (2005) Radiotherapy and Oncology, 76 (2), pp. 157-161. , DOI 10.1016/j.radonc.2005.06.022, PII S0167814005002513
Begg, A.C., Vens, C., Genetic manipulation of radiosensitivity (2001) International Journal of Radiation Oncology Biology Physics, 49 (2), pp. 367-371. , DOI 10.1016/S0360-3016(00)01497-8, PII S0360301600014978
Pedicini, P., Caivano, R., Jereczek-Fossa, B.A., Strigari, L., Vischioni, B., Alterio, D., Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (2012) Theol Biol Med Mod., 9, p. 23
Steel, G.G., Cell loss as a factor in the growth rate of human tumours (1967) Eur J Cancer., 3, pp. 381-387
Trott, K.-R., The mechanisms of acceleration of repopulation in squamous epithelia during daily irradiation (1999) Acta Oncologica, 38 (2), pp. 153-157. , DOI 10.1080/028418699431555
Marcu, L., Van Doorn, T., Olver, I., Modelling of post-irradiation accelerated repopulation in squamous cell carcinomas (2004) Physics in Medicine and Biology, 49 (16), pp. 3767-3779. , DOI 10.1088/0031-9155/49/16/021, PII S0031915504736520
Bernier, J., Horiot, J.C., Altered-fractionated radiotherapy in locally advanced head and neck cancer (2012) Curr Opin Oncol., 24, pp. 223-228
Fiorentino, A., Cozzolino, M., Caivano, R., Pedicini, P., Chiumento, C., Oliviero, C., Cone-beam computed tomography dose monitoring during intensitymodulated radiotherapy in head and neck cancer: Parotid glands (2012) Clin Transl Oncol., , doi:10.1007/s1209401209464
Eriksen, J. G., Steiniche, T., Askaa, J., Alsner, J., Overgaard, J., The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck (2004) International Journal of Radiation Oncology Biology Physics, 58 (2), pp. 561-566. , DOI 10. 1016/j. ijrobp. 2003. 09. 043
Bentzen, S. M., Atasoy, B. M., Daley, F. M., Dische, S., Richman, P. I., Saunders, M. I., Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial (2005) J Clin Oncol., 23, pp. 5560-5567
Chung, C. H., Zhang, Q., Hammond, E. M., Trotti III, A. M., Wang, H., Spencer, S., Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head and neck squamous cell carcinoma (2011) Int J Radiat Oncol Biol Phys., 81, pp. 331-338
Thames, H. D., Bentzen, S. M., Turesson, I., Overgaard, M., Van Den Bogaert, W., Time-dose factors in radiotherapy: A review of the human data (1990) Radiotherapy and Oncology, 19 (3), pp. 219-235
Bentzen, S. M., Johansen, L. V., Overgaard, J., Thames, H. D., Clinical radiobiology of squamous cell carcinoma of the oropharynx (1991) Int J Radiat Oncol Biol Phys., 20, pp. 1197-1206
Withers, H. R., Taylor, J. M. G., MacIejewski, B., The hazard of accelerated tumour clonogen repopulation during radiotherapy (1988) Acta Oncol., 27, pp. 131-146
Thames Jr., H. D., Rozell, M. E., Tucker, S. L., Direct analysis of quantal radiation response data (1986) International Journal of Radiation Biology, 49 (6), pp. 999-1009
Barendsen, G. W., Dose fractionation, dose rate and isoeffect relationships for normal tissue responses (1982) Int J Radiat Oncol Biol Phys., 8, pp. 779-790
Hildebrandt, M. A., Lippman, S. M., Etzel, C. J., Kim, E., Lee, J. J., Khuri, F. R., Genetic variant in the PI3K/PTEN/AKT/mTOR pathway predict head and neck cancer patient second primary tumor/recurrence risk and response to retinoid chemoprevention (2012) Clin Cancer Res., 18, pp. 3705-3713
Begg, A. C., Vens, C., Genetic manipulation of radiosensitivity (2001) International Journal of Radiation Oncology Biology Physics, 49 (2), pp. 367-371. , DOI 10. 1016/S0360-3016 (00) 01497-8, PII S0360301600014978
Steel, G. G., Cell loss as a factor in the growth rate of human tumours (1967) Eur J Cancer., 3, pp. 381-387
Trott, K. -R., The mechanisms of acceleration of repopulation in squamous epithelia during daily irradiation (1999) Acta Oncologica, 38 (2), pp. 153-157. , DOI 10. 1080/028418699431555
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.6, 5-year impact factor: 1.379
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84886595505&partnerID=40&md5=714a83eb269f4e06a7f7aff5e3996526
Keywords: Accelerated Proliferation, Doubling Time, Pten Expression, Radiosensitivity, Phosphatidylinositol 3, 5 Trisphosphate 3 Phosphatase, Article, Cancer Radiotherapy, Controlled Study, Head And Neck Squamous Cell Carcinoma, Human, Postoperative Care, Postoperative Radiotherapy, Predictive Value, Protein Expression, Radiation Dose Fractionation, Algorithms, Cell Proliferation, Disease Progression, Follow-Up Studies, Head And Neck Neoplasms, Neoplasm Recurrence, Local, Postoperative Period, Prognosis, Pten Phosphohydrolase, Radiation Injuries, Tumor Markers, Biological,
Affiliations:
*** IBB - CNR ***
Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028 Rionero in Vulture, PZ, Italy
I.R.C.C.S. SDN Foundation, Naples, Italy
I. R. C. C. S. SDN Foundation, Naples, Italy
References:
Overgaard, J., Alsner, J., Eriksen, J., Horsman, M.R., Grau, C., Importance of overall treatment time for the response to radiotherapy in patients with squamous cell carcinoma of the head and neck (2000) Rays., 25, pp. 313-31
Overgaard, J., Hansen, H.S., Specht, L., Overgaard, M., Grau, C., Andersen, E., Bentzen, J., Evensen, J.F., Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial (2003) Lancet, 362 (9388), pp. 933-940. , DOI 10.1016/S0140-6736(03)14361-9
Hansen, O., Overgaard, J., Hansen, H.S., Overgaard, M., Hoyer, M., Jorgensen, K.E., Bastholt, L., Berthelsen, A., Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma: Dependency on tumor differentiation (1997) Radiotherapy and Oncology, 43 (1), pp. 47-51. , DOI 10.1016/S0167-8140(97)01904-X, PII S016781409701904X
Dassonville, O., Formento, J.L., Francoual, M., Ramaioli, A., Santini, J., Schneider, M., Demard, F., Milano, G., Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer (1993) Journal of Clinical Oncology, 11 (10), pp. 1873-1878
Eriksen, J.G., Steiniche, T., Askaa, J., Alsner, J., Overgaard, J., The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck (2004) International Journal of Radiation Oncology Biology Physics, 58 (2), pp. 561-566. , DOI 10.1016/j.ijrobp.2003.09.043
Bentzen, S.M., Atasoy, B.M., Daley, F.M., Dische, S., Richman, P.I., Saunders, M.I., Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial (2005) J Clin Oncol., 23, pp. 5560-5567
Suwinski, R., Jaworska, M., Nikiel, B., Grzegorz, W., Bankowska-Wozniak, M., Wojciech, M., Predicting the effect of accelerated fractionation in postoperative radiotherapy for head and neck cancer based on molecular marker profiles: Data from a randomized clinical trial (2010) Int J Radiat Oncol Biol Phys., 77, pp. 438-446
Chung, C.H., Zhang, Q., Hammond, E.M., Trotti III, A.M., Wang, H., Spencer, S., Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head and neck squamous cell carcinoma (2011) Int J Radiat Oncol Biol Phys., 81, pp. 331-338
Snietura, M., Jaworska, M., Mlynarczyk Liszka, J., Goraj-Zajac, A., Piglowski, W., Lange, D., PTEN as a prognostic and predictive marker in postoperative radiotherapy for squamous cell cancer of the head and neck (2012) PLoS One., 7, pp. e33396
Pedicini, P., Strigari, L., Benassi, M., Estimation of a self consistent set of radiobiological parameters from hypofractionated versus standard radiotherapy of prostate cancer (2013) Int J Radiat Oncol Biol Phys., , doi:10.1016/j.ijrobp. 2012.11.033
Pedicini, P., Nappi, A., Strigari, L., Alicia Jereczek-Fossa, B., Alterio, D., Cremonesi, M., Correlation between EGFR expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (2012) Radiat Oncol., 7, p. 143
Thames, H.D., Bentzen, S.M., Turesson, I., Overgaard, M., Van Den Bogaert, W., Time-dose factors in radiotherapy: A review of the human data (1990) Radiotherapy and Oncology, 19 (3), pp. 219-235
Bentzen, S.M., Johansen, L.V., Overgaard, J., Thames, H.D., Clinical radiobiology of squamous cell carcinoma of the oropharynx (1991) Int J Radiat Oncol Biol Phys., 20, pp. 1197-1206
Withers, H.R., Taylor, J.M.G., MacIejewski, B., The hazard of accelerated tumour clonogen repopulation during radiotherapy (1988) Acta Oncol., 27, pp. 131-146
Robertson, C., Robertson, A.G., Hendry, J.H., Roberts, S.A., Slevin, N.J., Duncan, W.B., MacDougall, R.H., Keane, T.J., Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four centers (1998) International Journal of Radiation Oncology Biology Physics, 40 (2), pp. 319-329. , DOI 10.1016/S0360-3016(97)00716-5, PII S0360301697007165
Thames Jr., H.D., Rozell, M.E., Tucker, S.L., Direct analysis of quantal radiation response data (1986) International Journal of Radiation Biology, 49 (6), pp. 999-1009
Collett, D., (1994) Modelling Survival Data-in Medical Research, , London (UK): Chapman and Hall
Barendsen, G.W., Dose fractionation, dose rate and isoeffect relationships for normal tissue responses (1982) Int J Radiat Oncol Biol Phys., 8, pp. 779-790
Hildebrandt, M.A., Lippman, S.M., Etzel, C.J., Kim, E., Lee, J.J., Khuri, F.R., Genetic variant in the PI3K/PTEN/AKT/mTOR pathway predict head and neck cancer patient second primary tumor/recurrence risk and response to retinoid chemoprevention (2012) Clin Cancer Res., 18, pp. 3705-3713
Salmena, L., Carracedo, A., Pandolfi, P.P., Tenets of PTEN Tumor Suppression (2008) Cell, 133 (3), pp. 403-414. , DOI 10.1016/j.cell.2008.04.013, PII S0092867408005047
Wang, X., Jiang, X., PTEN: A default gate-keeping tumor suppressor with a versatile tail (2008) Cell Res., 18, pp. 807-816
Dittmann, K., Mayer, C., Rodemann, H.-P., Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity (2005) Radiotherapy and Oncology, 76 (2), pp. 157-161. , DOI 10.1016/j.radonc.2005.06.022, PII S0167814005002513
Begg, A.C., Vens, C., Genetic manipulation of radiosensitivity (2001) International Journal of Radiation Oncology Biology Physics, 49 (2), pp. 367-371. , DOI 10.1016/S0360-3016(00)01497-8, PII S0360301600014978
Pedicini, P., Caivano, R., Jereczek-Fossa, B.A., Strigari, L., Vischioni, B., Alterio, D., Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (2012) Theol Biol Med Mod., 9, p. 23
Steel, G.G., Cell loss as a factor in the growth rate of human tumours (1967) Eur J Cancer., 3, pp. 381-387
Trott, K.-R., The mechanisms of acceleration of repopulation in squamous epithelia during daily irradiation (1999) Acta Oncologica, 38 (2), pp. 153-157. , DOI 10.1080/028418699431555
Marcu, L., Van Doorn, T., Olver, I., Modelling of post-irradiation accelerated repopulation in squamous cell carcinomas (2004) Physics in Medicine and Biology, 49 (16), pp. 3767-3779. , DOI 10.1088/0031-9155/49/16/021, PII S0031915504736520
Bernier, J., Horiot, J.C., Altered-fractionated radiotherapy in locally advanced head and neck cancer (2012) Curr Opin Oncol., 24, pp. 223-228
Fiorentino, A., Cozzolino, M., Caivano, R., Pedicini, P., Chiumento, C., Oliviero, C., Cone-beam computed tomography dose monitoring during intensitymodulated radiotherapy in head and neck cancer: Parotid glands (2012) Clin Transl Oncol., , doi:10.1007/s1209401209464
Eriksen, J. G., Steiniche, T., Askaa, J., Alsner, J., Overgaard, J., The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck (2004) International Journal of Radiation Oncology Biology Physics, 58 (2), pp. 561-566. , DOI 10. 1016/j. ijrobp. 2003. 09. 043
Bentzen, S. M., Atasoy, B. M., Daley, F. M., Dische, S., Richman, P. I., Saunders, M. I., Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial (2005) J Clin Oncol., 23, pp. 5560-5567
Chung, C. H., Zhang, Q., Hammond, E. M., Trotti III, A. M., Wang, H., Spencer, S., Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head and neck squamous cell carcinoma (2011) Int J Radiat Oncol Biol Phys., 81, pp. 331-338
Thames, H. D., Bentzen, S. M., Turesson, I., Overgaard, M., Van Den Bogaert, W., Time-dose factors in radiotherapy: A review of the human data (1990) Radiotherapy and Oncology, 19 (3), pp. 219-235
Bentzen, S. M., Johansen, L. V., Overgaard, J., Thames, H. D., Clinical radiobiology of squamous cell carcinoma of the oropharynx (1991) Int J Radiat Oncol Biol Phys., 20, pp. 1197-1206
Withers, H. R., Taylor, J. M. G., MacIejewski, B., The hazard of accelerated tumour clonogen repopulation during radiotherapy (1988) Acta Oncol., 27, pp. 131-146
Thames Jr., H. D., Rozell, M. E., Tucker, S. L., Direct analysis of quantal radiation response data (1986) International Journal of Radiation Biology, 49 (6), pp. 999-1009
Barendsen, G. W., Dose fractionation, dose rate and isoeffect relationships for normal tissue responses (1982) Int J Radiat Oncol Biol Phys., 8, pp. 779-790
Hildebrandt, M. A., Lippman, S. M., Etzel, C. J., Kim, E., Lee, J. J., Khuri, F. R., Genetic variant in the PI3K/PTEN/AKT/mTOR pathway predict head and neck cancer patient second primary tumor/recurrence risk and response to retinoid chemoprevention (2012) Clin Cancer Res., 18, pp. 3705-3713
Begg, A. C., Vens, C., Genetic manipulation of radiosensitivity (2001) International Journal of Radiation Oncology Biology Physics, 49 (2), pp. 367-371. , DOI 10. 1016/S0360-3016 (00) 01497-8, PII S0360301600014978
Steel, G. G., Cell loss as a factor in the growth rate of human tumours (1967) Eur J Cancer., 3, pp. 381-387
Trott, K. -R., The mechanisms of acceleration of repopulation in squamous epithelia during daily irradiation (1999) Acta Oncologica, 38 (2), pp. 153-157. , DOI 10. 1080/028418699431555
Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma
Purpose: To estimate the impact of PTEN expression in terms of effective doubling time (Td) and dose per fraction which compensates the accelerated proliferation during the radiotherapy (Dprolif) when the overall treatment time (OTT) is reduced in accelerated radiotherapy of head and neck squamous cell carcinoma (HNSCC). Materials and methods: Data were carried out from a recent paper comparing the local control rate (LCR) for patients with HNSCC that underwent a conventional (p-CF) or accelerated radiotherapy (p-CAIR) and a pretreatment assessment of PTEN expression. The impact of PTEN over expression was assessed using the Clinical Efficacy Factor (C) and assuming a plausible range of intrinsic radiosensitivity (α). Statistical analysis was made by evaluating the LCR from Kaplan-Meier curves and logrank test with significance of 0.05. Results: C indexes were 1.46 and 0.23 for the high-versus low-PTEN group, corresponding to a considerable reduction of doubling time of more than six times (6.6 versus 42.2 days). The median estimate of D prolif was 0.51 versus 0.08 Gy/day if referred to a median value in the adopted range of α. Conclusions: The PTEN expression has a significant implication on the clinical management of these patient groups. Our data support the hypothesis that the high-PTEN group would benefit from a hypo-fractionation with a reduction of the OTT to compensate for the increase in the proliferation rate, while the low-PTEN group could benefits from a hyper-fractionation which would result in a reduced toxicity for all the organs at risk. © Federación de Sociedades Españolas de Oncología (FESEO) 2013.
Purpose: To estimate the impact of PTEN expression in terms of effective doubling time (Td) and dose per fraction which compensates the accelerated proliferation during the radiotherapy (Dprolif) when the overall treatment time (OTT) is reduced in accelerated radiotherapy of head and neck squamous cell carcinoma (HNSCC). Materials and methods: Data were carried out from a recent paper comparing the local control rate (LCR) for patients with HNSCC that underwent a conventional (p-CF) or accelerated radiotherapy (p-CAIR) and a pretreatment assessment of PTEN expression. The impact of PTEN over expression was assessed using the Clinical Efficacy Factor (C) and assuming a plausible range of intrinsic radiosensitivity (α). Statistical analysis was made by evaluating the LCR from Kaplan-Meier curves and logrank test with significance of 0.05. Results: C indexes were 1.46 and 0.23 for the high-versus low-PTEN group, corresponding to a considerable reduction of doubling time of more than six times (6.6 versus 42.2 days). The median estimate of D prolif was 0.51 versus 0.08 Gy/day if referred to a median value in the adopted range of α. Conclusions: The PTEN expression has a significant implication on the clinical management of these patient groups. Our data support the hypothesis that the high-PTEN group would benefit from a hypo-fractionation with a reduction of the OTT to compensate for the increase in the proliferation rate, while the low-PTEN group could benefits from a hyper-fractionation which would result in a reduced toxicity for all the organs at risk. © Federación de Sociedades Españolas de Oncología (FESEO) 2013.
Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma
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Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma
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Nat Commun (ISSN: 2041-1723, 2041-1723electronic, 2041-1723linking), 2015; 6: N/D-N/D.
Impact Factor: 11.329
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M
* Cd And Nmr Conformational Studies Of A Peptide Encompassing The Mid Loop Interface Of Ship2-Sam (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Nov; 101(11): 1088-1098.
Impact Factor: 2.385
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Pedicini P, Fiorentino A, Simeon V, Tini P, Chiumento C, Pirtoli L, Salvatore M, Storto G
* Clinical radiobiology of glioblastoma multiforme: estimation of tumor control probability from various radiotherapy fractionation schemes (387 views)
Strahlenther Onkol (ISSN: 0179-7158, 0179-7158linking), 2014 Oct; 190(10): 925-932.
Impact Factor: 2.914
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (402 views)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (546 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (489 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
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Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (385 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (518 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Casciaro S, Conversano F, Ragusa A, Malvindi MA, Franchini R, Greco A, Pellegrino T, Gigli G
* Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies (403 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2010 Nov; 45(11): 715-724.
Impact Factor: 4.67
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Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (470 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (708 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
* Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling (462 views)
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Impact Factor: 7.093
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (468 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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* Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-beta-OTX2-SNAIL via PTEN inhibition (1252 views)
Brain (ISSN: 1460-2156electronic, 0006-8950linking), 2018 May 1; 141(5): 1300-1319.
Impact Factor: 9.915
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Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (365 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
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Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E
* PI3K-C2γ 3 is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling (231 views)
Nat Commun (ISSN: 2041-1723, 2041-1723electronic, 2041-1723linking), 2015; 6: N/D-N/D.
Impact Factor: 11.329
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M
* Cd And Nmr Conformational Studies Of A Peptide Encompassing The Mid Loop Interface Of Ship2-Sam (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Nov; 101(11): 1088-1098.
Impact Factor: 2.385
View Export to BibTeX Export to EndNote
Pedicini P, Fiorentino A, Simeon V, Tini P, Chiumento C, Pirtoli L, Salvatore M, Storto G
* Clinical radiobiology of glioblastoma multiforme: estimation of tumor control probability from various radiotherapy fractionation schemes (387 views)
Strahlenther Onkol (ISSN: 0179-7158, 0179-7158linking), 2014 Oct; 190(10): 925-932.
Impact Factor: 2.914
View Export to BibTeX Export to EndNote
Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (402 views)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
View Export to BibTeX Export to EndNote
Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (546 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
View Export to BibTeX Export to EndNote
Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (489 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (385 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
View Export to BibTeX Export to EndNote
Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (518 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
View Export to BibTeX Export to EndNote
Casciaro S, Conversano F, Ragusa A, Malvindi MA, Franchini R, Greco A, Pellegrino T, Gigli G
* Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies (403 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2010 Nov; 45(11): 715-724.
Impact Factor: 4.67
View Export to BibTeX Export to EndNote
Romano S, D'Angelillo A, Pacelli R, Staibano S, De Luna E, Bisogni R, Eskelinen EL, Mascolo M, Calì G, Arra C, Romano M
* Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (470 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic, 1350-9047linking), 2010 Jan; 17(1): 145-157.
Impact Factor: 9.05
View Export to BibTeX Export to EndNote
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (708 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
View Export to BibTeX Export to EndNote
Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
* Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling (462 views)
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Impact Factor: 7.093
View Export to BibTeX Export to EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
View Export to BibTeX Export to EndNote
Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (468 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
View Export to BibTeX Export to EndNote
18 Records (15 excluding Abstracts).
Total impact factor: 94.228 (84.616 excluding Abstracts).
Total 5 year impact factor: 92.432 (82.181 excluding Abstracts).
Total impact factor: 94.228 (84.616 excluding Abstracts).
Total 5 year impact factor: 92.432 (82.181 excluding Abstracts).
291 views. Last view on Wednesday 22 March 2023, 0:47:00
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