Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma (415 views)
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
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Paper type: Journal Article,
Impact factor: 1.6, 5-year impact factor: 1.379
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84886595505&partnerID=40&md5=714a83eb269f4e06a7f7aff5e3996526
Keywords: Accelerated Proliferation, Doubling Time, Pten Expression, Radiosensitivity, Phosphatidylinositol 3, 5 Trisphosphate 3 Phosphatase, Article, Cancer Radiotherapy, Controlled Study, Head And Neck Squamous Cell Carcinoma, Human, Postoperative Care, Postoperative Radiotherapy, Predictive Value, Protein Expression, Radiation Dose Fractionation, Algorithms, Cell Proliferation, Disease Progression, Follow-Up Studies, Head And Neck Neoplasms, Neoplasm Recurrence, Local, Postoperative Period, Prognosis, Pten Phosphohydrolase, Radiation Injuries, Tumor Markers, Biological,
Affiliations:
*** IBB - CNR ***
Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028 Rionero in Vulture, PZ, Italy
I.R.C.C.S. SDN Foundation, Naples, Italy
I. R. C. C. S. SDN Foundation, Naples, Italy
References:
Not available.
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.6, 5-year impact factor: 1.379
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84886595505&partnerID=40&md5=714a83eb269f4e06a7f7aff5e3996526
Keywords: Accelerated Proliferation, Doubling Time, Pten Expression, Radiosensitivity, Phosphatidylinositol 3, 5 Trisphosphate 3 Phosphatase, Article, Cancer Radiotherapy, Controlled Study, Head And Neck Squamous Cell Carcinoma, Human, Postoperative Care, Postoperative Radiotherapy, Predictive Value, Protein Expression, Radiation Dose Fractionation, Algorithms, Cell Proliferation, Disease Progression, Follow-Up Studies, Head And Neck Neoplasms, Neoplasm Recurrence, Local, Postoperative Period, Prognosis, Pten Phosphohydrolase, Radiation Injuries, Tumor Markers, Biological,
Affiliations:
*** IBB - CNR ***
Department of Radiation Oncology, I.R.C.C.S. C.R.O.B Regional Cancer Hospital, 1-Padre-Pio-Street, 85028 Rionero in Vulture, PZ, Italy
I.R.C.C.S. SDN Foundation, Naples, Italy
I. R. C. C. S. SDN Foundation, Naples, Italy
References:
Not available.
Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma
Purpose: To estimate the impact of PTEN expression in terms of effective doubling time (Td) and dose per fraction which compensates the accelerated proliferation during the radiotherapy (Dprolif) when the overall treatment time (OTT) is reduced in accelerated radiotherapy of head and neck squamous cell carcinoma (HNSCC). Materials and methods: Data were carried out from a recent paper comparing the local control rate (LCR) for patients with HNSCC that underwent a conventional (p-CF) or accelerated radiotherapy (p-CAIR) and a pretreatment assessment of PTEN expression. The impact of PTEN over expression was assessed using the Clinical Efficacy Factor (C) and assuming a plausible range of intrinsic radiosensitivity (α). Statistical analysis was made by evaluating the LCR from Kaplan-Meier curves and logrank test with significance of 0.05. Results: C indexes were 1.46 and 0.23 for the high-versus low-PTEN group, corresponding to a considerable reduction of doubling time of more than six times (6.6 versus 42.2 days). The median estimate of D prolif was 0.51 versus 0.08 Gy/day if referred to a median value in the adopted range of α. Conclusions: The PTEN expression has a significant implication on the clinical management of these patient groups. Our data support the hypothesis that the high-PTEN group would benefit from a hypo-fractionation with a reduction of the OTT to compensate for the increase in the proliferation rate, while the low-PTEN group could benefits from a hyper-fractionation which would result in a reduced toxicity for all the organs at risk. © Federación de Sociedades Españolas de Oncología (FESEO) 2013.
Purpose: To estimate the impact of PTEN expression in terms of effective doubling time (Td) and dose per fraction which compensates the accelerated proliferation during the radiotherapy (Dprolif) when the overall treatment time (OTT) is reduced in accelerated radiotherapy of head and neck squamous cell carcinoma (HNSCC). Materials and methods: Data were carried out from a recent paper comparing the local control rate (LCR) for patients with HNSCC that underwent a conventional (p-CF) or accelerated radiotherapy (p-CAIR) and a pretreatment assessment of PTEN expression. The impact of PTEN over expression was assessed using the Clinical Efficacy Factor (C) and assuming a plausible range of intrinsic radiosensitivity (α). Statistical analysis was made by evaluating the LCR from Kaplan-Meier curves and logrank test with significance of 0.05. Results: C indexes were 1.46 and 0.23 for the high-versus low-PTEN group, corresponding to a considerable reduction of doubling time of more than six times (6.6 versus 42.2 days). The median estimate of D prolif was 0.51 versus 0.08 Gy/day if referred to a median value in the adopted range of α. Conclusions: The PTEN expression has a significant implication on the clinical management of these patient groups. Our data support the hypothesis that the high-PTEN group would benefit from a hypo-fractionation with a reduction of the OTT to compensate for the increase in the proliferation rate, while the low-PTEN group could benefits from a hyper-fractionation which would result in a reduced toxicity for all the organs at risk. © Federación de Sociedades Españolas de Oncología (FESEO) 2013.
Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma
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Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
18 Records (15 excluding Abstracts).
Total impact factor: 94.228 (84.616 excluding Abstracts).
Total 5 year impact factor: 92.432 (82.181 excluding Abstracts).
Total impact factor: 94.228 (84.616 excluding Abstracts).
Total 5 year impact factor: 92.432 (82.181 excluding Abstracts).
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