In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (382 views visite)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.945, 5-year impact factor Impact factor a 5 anni: 3.017
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846021302&partnerID=40&md5=46a54974bb0004c849a19486e5415e04
Keywords Parole chiave: Ap Maldi-Ms, Matrix Metalloproteinases, Mmp Immobilization, Solid-State Assay, Atmospheric Pressure, Bioassay, Enzyme Immobilization, Enzyme Inhibition, Gold, Mass Spectrometry, Molecular Weight, Pathology, Surface Plasmon Resonance, Tumors, Embryogenesis, Matrix Metalloproteinases (mmp), Molecular Mass Identification, Interstitial Collagenase, Macrophage Elastase, Neutrophil Collagenase, Peptidase, Amino Acid Sequence, Conference Paper, Enzyme Activity, Enzyme Analysis, Matrix Assisted Laser Desorption Ionization Time Of Flight Mass Spectrometry, Priority Journal, Protein Determination, Protein Function, Protein Immobilization, Sequence Analysis, Solid State, Humans, Matrix Metalloproteinase 12, Matrix-Assisted Laser Desorption-Ionization, Trypsin,
Affiliations Affiliazioni:
*** IBB - CNR ***
Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, Via C. Ulpiani 27, Bari, Italy
Magnetic Resonance Center, CERM, University of Florence, Via L. Sacconi, 6, Sesto Fiorentino, Italy
Department of Agricultural Biotechnology, University of Florence, P.le delle Cascine, 24, Florence, Italy
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125, Catania, Italy
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy
References Riferimenti:
MacBeath, G., Schreiber, S.L., Printing proteins as microarrays for high-throughput function determination (2000) Science, 289, p. 176
Zhu, H., Bilgin, M., Bangham, R., Hall, D., Casamayor, A., Bertone, P., Lan, N., Snyder, M., Global analysis of protein activities using proteome chips (2001) Science, 293, p. 2101
Houseman, B.T., Huk, J.H., Kron, S.J., Mrksich, M., Peptide chips for the quantitative evaluation of protein kinase activity (2002) Nat. Biotechnol, 20, p. 270
Huber, A., Demartis, S., Neri, D., The use of biosensor technology for the engineering of antibodies and enzymes (1999) J. Mol. Recognit, 12, p. 198
Reymond, J.L., (2006) Enzyme Assays: High-throughput Screening, Genetic Selection and Fingerprinting, , Wiley-VCH Verlag GmbH and Co. KGaA: Weinheim
Min, D., Mrksich, M., Profiling kinase activities by using a peptide chip and mass spectrometry (2004) Angew. Chem., Int. Ed. Engl, 43, p. 5973
Babiak, P., Reymond, J., A high-throughput, low-volume enzyme assay on solid support (2005) Anal. Chem, 77, p. 373
Huber, W., Hoffman, F., A new strategy for improved secondary screening and lead optimization using high-resolution SPR characterization of compound-target interactions (2005) J. Mol. Recognit, 18, p. 273
Nedelkov, D., Nelson, R.W., Surface plasmon resonance mass spectrometry for protein analysis (2006) Methods Mol. Biol, 328, p. 131
Borch, J., Roepstorff, P., Screening for enzyme inhibitors by surface plasmon resonance combined with mass spectrometry (2004) Anal. Chem, 76, p. 5243
Hutchens, T., Yip, T.T., New desorption strategies for the mass spectrometric analysis of macromolecules (1993) Rapid Commun. Mass Spectrom, 7, p. 576
Caputo, E., Moharram, R., Martin, B.M., Methods for on-chip analysis (2003) Anal. Biochem, 321, p. 116
Merchant, M., Weinberger, S.R., Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (2000) Electrophoresis, 21, p. 1164
Griesser, H.J., Kingshott, P., McArthur, S.L., McLean, K.M., Kinsel, G.R., Timmons, R.B., Surface-MALDI mass spectrometry in biomaterials research (2004) Biomaterials, 25, p. 4861
Clarke, C.H., Buckley, J.A., Fung, E.T., SELDI-TOF-MS proteomics of breast cancer (2005) Clin. Chem. Lab. Med, 43, p. 1314
Bons, J.A.P., Wodzig, W.K.W.H., van Dieijen-Visser, M.P., Protein profiling as a diagnostic tool in clinical chemistry: A review (2005) Clin. Chem. Lab. Med, 43, p. 1281
Issaq, H.J., Conrads, T.P., Prieto, D.A., Tirumalai, R., Veenstra, T.D., SELDI-TOF MS for diagnostic proteomics (2003) Anal. Chem, 1, pp. 149A
Ge, Y., Gibbs, B.F., Masse, R., Complete chemical and enzymatic treatment of phosphorylated and glycosylated proteins on proteinchip arrays (2005) Anal. Chem, 77, p. 3644
Shen, Z., Go, E.P., Gamez, A., Apon, J.V., Fokin, V., Greig, M., Ventura, M., Siuzdak, G., A mass spectrometry plate reader: Monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform (2004) Chembiochem, 5, p. 921
Min, D., Tang, W., Mrksich, M., Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor (2004) Nat. Biotechnol, 22, p. 717
Bornsen, K.O., Gass, M.A.S., Bruin, G.J.M., von Adrichem, J.H.M., Biro, M.C., Kresbach, G.M., Ehrat, M., Influence of solvents and detergents on matrix-assisted laser desorption/ionization mass spectrometry measurements of proteins and oligonucleotides (1997) Rapid Commun. Mass Spectrom, 11, p. 603
Brockman, A.H., Dodd, B.S., Orlando, N., A desalting approach for MALDI-MS using on-probe hydrofobic self-assembled monolayers (1997) Anal. Chem, 69, p. 4716
Worral, T.A., Cotter, R.J., Woods, A.S., Purification of contaminated peptides on synthetic membrane surfaces for matrix-assisted laser desorption/ionization mass spectrometry (1998) Anal. Chem, 70, p. 750
Warren, M.E., Brockman, A.H., Orlando, R., On-probe solid-phase extraction/MALDI-MS using ion-pairing interactions for the cleanup of peptides and proteins (1998) Anal. Chem, 70, p. 3757
Xu, Y., Watson, J.T., Bruening, M.L., Patterned monolayer/polymer films for analysis of dilute or salt-contaminated protein samples by MALDI-MS (2003) Anal. Chem, 75, p. 185
Wang, Y., Xia, X., Guo, Y., Porous anodic alumina membrane as a sample support for MALDI-TOF MS analysis of salt-containing proteins (2005) J. Am. Soc. Mass Spectrom, 16, p. 1488
Smirnov, I.P., Zhu, X., Taylor, T., Huang, Y., Ross, P., Papayanopoulos, I.A., Martin, S.A., Pappin, D.J., Suppression of α-Cyano-4-hydroxycinnamic acid matrix clusters and reduction of chemical noise in MALDI-TOF mass spectrometry (2004) Anal. Chem, 76, p. 2958
Kim, J.-S., Kim, J.-Y., Kim, H.-J., Suppression of matrix clusters and enhancement of peptide signals in MALDI-TOF mass spectrometry using nitrilotriacetic acid (2005) Anal. Chem, 77, p. 7483
Newton, K.A., McLuckey, S.A., Generation and manipulation of Sodium cationized peptides in the gas phase (2004) J. Am. Soc. Mass Spectrom, 15, p. 607
Su, J., Mrksich, M., Using MALDI-TOF mass spectrometry to characterize interfacial reactions on self-assembled monolayers (2003) Langmuir, 19, p. 4867
Grasso, G., D'Agata, R., Rizzarelli, E., Spoto, G., D'Andrea, L., Pedone, C., Picardi, A., Yeo, K.J., Activity of anchored human matrix metalloproteinase-1 catalytic domain on au (111) surfaces monitored by ESI-MS (2005) J. Mass Spectrom, 40, p. 1565
Massova, I., Kotra, L.P., Fridman, R., Mobashery, S., Matrix metalloproteinases: Structures, evolution, and diversification (1998) FASEB J, 12, p. 1075
Coussens, L.M., Werb, Z., Matrix metalloproteinases and the development of cancer (1996) Chem. Biol, 3, p. 895
Koivunen, E., Arap, W., Valtanen, H., Rainisalo, A., Medina, O.P., Heikkilä, P., Kantor, C., Pasqualini, R., Tumor targeting with a selective gelatinase inhibitor (1999) Nat. Biotechnol, 17, p. 768
Farkas, E., Katz, Y., Bhusare, S., Reich, R., Röschenthaler, G., Königsmann, M., Breuer, E., Carbamoylphosphonate Based Matrix Metalloproteinase (MMP) inhibitor metal complexes-solution studies and stability constants. Towards a zinc selective binding group (2004) J. Biol. Inorg. Chem, 9, p. 307
Schneider, B.B., Lock, C., Covey, T.R., AP and vacuum MALDI on a QqLIT instrument (2005) J. Am. Soc. Mass Spectrom, 16, p. 176
Trimpin, S., Deinzer, M.L., Solvent-free MALDI-MS for the analysis of biological samples via a mini-ball mill approach (2005) J. Am. Soc. Mass Spectrom, 16, p. 542
Whitesides, G., Xia, Y., Soft lithography (1998) Angew. Chem., Int. Ed. Engl, 37, p. 550
Navratilova, I., Eisenstien, E., Myszka, D.G., Measuring long association phases using Biacore (2005) Anal. Biochem, 344, p. 295
Larsericsdotter, H., Oscarsson, S., Buijs, J., Structure, stability, and orientation of BSA adsorbed to silica (2005) J. Colloid Interface Sci, 289, p. 26
Tan, P.V., Laiko, V.V., Doroshenko, V.M., Atmospheric pressure MALDI with pulsed dynamic focusing for high-efficiency transmission of ions into a mass spectrometer (2004) Anal. Chem, 75, p. 2462
Bertini, I., Calderone, V., Cosenza, M., Fragai, M., Lee, Y.-M., Luchinat, C., Mangani, S., Turano, P., Conformational variability of matrix metalloproteinases: Beyond a single 3D structure (2005) Proc. Natl. Acad. Sci. U.S.A, 102, p. 5334
Buchardt, J., Schiodt, C.B., Krog-Jensen, C., Delaisse, J.-M., Foged, N.T., Meldal, M., Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors (2000) J. Comb. Chem, 2, p. 624
Feng, R., Castelhano, A.L., Billedeau, R., Yuan, Z., Study of noncovalent enzyme-inhibitor complexes and metal binding stoichiometry of matrilysin by electrospray ionization mass spectrometry (1995) J. Am. Soc. Mass Spectrom, 6, p. 1105
Sung, J.Y., Park, S.M., Lee, C.-H., Um, J.W., Lee, H.J., Kim, J., Oh, Y.J., Chung, K.C., Proteolytic cleavage of extracellular secreted a-synuclein via matrix metalloproteinases (2005) J. Biol. Chem, 280, pp. 25-216
Lauer-Fields, J.L., Nagase, H., Fields, G.B., Use of edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases (2000) J. Chromatogr., A, 890, p. 117
Gossas, T., Danielason, U.H., Characterization of Ca2+ interactions with matrix metallopeptidase-12: Implications for matrix metallopeptidase regulation (2006) Biochem. J, 398, p. 393
Willenbrock, F., Murphy, G., Phillips, I.R., Brocklehurst, K., The second zinc atom in the matrix metalloproteinase catalytic domain is absent in the full-length enzymes: A possible role for the C-terminal domain (1995) FEBS Lett, 358, p. 189
Knaeuper, V., Docherty, A.J.P., Smith, B., Tschesche, H., Murphy, G., Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis (1997) FEBS Lett, 405, p. 60
Kondo, A., Urabe, T., Temperature dependence of activity and conformational changes in a-amylases with different thermostability upon adsorption on ultrafine silica particles (1995) J. Colloid Interface Sci, 174, p. 191
Keller, A., Purvine, S., Nesvizhskii, A., Stolyar, S., Goodlett, D.R., Kolker, E., Experimental protein mixture for validating tandem mass spectral analysis (2002) OMICS, 6, p. 207
Houseman, B. T., Huk, J. H., Kron, S. J., Mrksich, M., Peptide chips for the quantitative evaluation of protein kinase activity (2002) Nat. Biotechnol, 20, p. 270
Reymond, J. L., (2006) Enzyme Assays: High-throughput Screening, Genetic Selection and Fingerprinting, , Wiley-VCH Verlag GmbH and Co. KGaA: Weinheim
Griesser, H. J., Kingshott, P., McArthur, S. L., McLean, K. M., Kinsel, G. R., Timmons, R. B., Surface-MALDI mass spectrometry in biomaterials research (2004) Biomaterials, 25, p. 4861
Clarke, C. H., Buckley, J. A., Fung, E. T., SELDI-TOF-MS proteomics of breast cancer (2005) Clin. Chem. Lab. Med, 43, p. 1314
Bons, J. A. P., Wodzig, W. K. W. H., van Dieijen-Visser, M. P., Protein profiling as a diagnostic tool in clinical chemistry: A review (2005) Clin. Chem. Lab. Med, 43, p. 1281
Issaq, H. J., Conrads, T. P., Prieto, D. A., Tirumalai, R., Veenstra, T. D., SELDI-TOF MS for diagnostic proteomics (2003) Anal. Chem, 1, pp. 149A
Ge, Y., Gibbs, B. F., Masse, R., Complete chemical and enzymatic treatment of phosphorylated and glycosylated proteins on proteinchip arrays (2005) Anal. Chem, 77, p. 3644
Shen, Z., Go, E. P., Gamez, A., Apon, J. V., Fokin, V., Greig, M., Ventura, M., Siuzdak, G., A mass spectrometry plate reader: Monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform (2004) Chembiochem, 5, p. 921
Bornsen, K. O., Gass, M. A. S., Bruin, G. J. M., von Adrichem, J. H. M., Biro, M. C., Kresbach, G. M., Ehrat, M., Influence of solvents and detergents on matrix-assisted laser desorption/ionization mass spectrometry measurements of proteins and oligonucleotides (1997) Rapid Commun. Mass Spectrom, 11, p. 603
Brockman, A. H., Dodd, B. S., Orlando, N., A desalting approach for MALDI-MS using on-probe hydrofobic self-assembled monolayers (1997) Anal. Chem, 69, p. 4716
Worral, T. A., Cotter, R. J., Woods, A. S., Purification of contaminated peptides on synthetic membrane surfaces for matrix-assisted laser desorption/ionization mass spectrometry (1998) Anal. Chem, 70, p. 750
Warren, M. E., Brockman, A. H., Orlando, R., On-probe solid-phase extraction/MALDI-MS using ion-pairing interactions for the cleanup of peptides and proteins (1998) Anal. Chem, 70, p. 3757
Xu, Y., Watson, J. T., Bruening, M. L., Patterned monolayer/polymer films for analysis of dilute or salt-contaminated protein samples by MALDI-MS (2003) Anal. Chem, 75, p. 185
Smirnov, I. P., Zhu, X., Taylor, T., Huang, Y., Ross, P., Papayanopoulos, I. A., Martin, S. A., Pappin, D. J., Suppression of -Cyano-4-hydroxycinnamic acid matrix clusters and reduction of chemical noise in MALDI-TOF mass spectrometry (2004) Anal. Chem, 76, p. 2958
Kim, J. -S., Kim, J. -Y., Kim, H. -J., Suppression of matrix clusters and enhancement of peptide signals in MALDI-TOF mass spectrometry using nitrilotriacetic acid (2005) Anal. Chem, 77, p. 7483
Newton, K. A., McLuckey, S. A., Generation and manipulation of Sodium cationized peptides in the gas phase (2004) J. Am. Soc. Mass Spectrom, 15, p. 607
Coussens, L. M., Werb, Z., Matrix metalloproteinases and the development of cancer (1996) Chem. Biol, 3, p. 895
Schneider, B. B., Lock, C., Covey, T. R., AP and vacuum MALDI on a QqLIT instrument (2005) J. Am. Soc. Mass Spectrom, 16, p. 176
Tan, P. V., Laiko, V. V., Doroshenko, V. M., Atmospheric pressure MALDI with pulsed dynamic focusing for high-efficiency transmission of ions into a mass spectrometer (2004) Anal. Chem, 75, p. 2462
Sung, J. Y., Park, S. M., Lee, C. -H., Um, J. W., Lee, H. J., Kim, J., Oh, Y. J., Chung, K. C., Proteolytic cleavage of extracellular secreted a-synuclein via matrix metalloproteinases (2005) J. Biol. Chem, 280, pp. 25-216
Lauer-Fields, J. L., Nagase, H., Fields, G. B., Use of edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases (2000) J. Chromatogr., A, 890, p. 117
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article,
Impact factor: 2.945, 5-year impact factor Impact factor a 5 anni: 3.017
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846021302&partnerID=40&md5=46a54974bb0004c849a19486e5415e04
Keywords Parole chiave: Ap Maldi-Ms, Matrix Metalloproteinases, Mmp Immobilization, Solid-State Assay, Atmospheric Pressure, Bioassay, Enzyme Immobilization, Enzyme Inhibition, Gold, Mass Spectrometry, Molecular Weight, Pathology, Surface Plasmon Resonance, Tumors, Embryogenesis, Matrix Metalloproteinases (mmp), Molecular Mass Identification, Interstitial Collagenase, Macrophage Elastase, Neutrophil Collagenase, Peptidase, Amino Acid Sequence, Conference Paper, Enzyme Activity, Enzyme Analysis, Matrix Assisted Laser Desorption Ionization Time Of Flight Mass Spectrometry, Priority Journal, Protein Determination, Protein Function, Protein Immobilization, Sequence Analysis, Solid State, Humans, Matrix Metalloproteinase 12, Matrix-Assisted Laser Desorption-Ionization, Trypsin,
Affiliations Affiliazioni:
*** IBB - CNR ***
Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, Via C. Ulpiani 27, Bari, Italy
Magnetic Resonance Center, CERM, University of Florence, Via L. Sacconi, 6, Sesto Fiorentino, Italy
Department of Agricultural Biotechnology, University of Florence, P.le delle Cascine, 24, Florence, Italy
Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125, Catania, Italy
Istituto Biostrutture e Bioimmagini, CNR, Viale A. Doria 6, Catania, Italy
References Riferimenti:
MacBeath, G., Schreiber, S.L., Printing proteins as microarrays for high-throughput function determination (2000) Science, 289, p. 176
Zhu, H., Bilgin, M., Bangham, R., Hall, D., Casamayor, A., Bertone, P., Lan, N., Snyder, M., Global analysis of protein activities using proteome chips (2001) Science, 293, p. 2101
Houseman, B.T., Huk, J.H., Kron, S.J., Mrksich, M., Peptide chips for the quantitative evaluation of protein kinase activity (2002) Nat. Biotechnol, 20, p. 270
Huber, A., Demartis, S., Neri, D., The use of biosensor technology for the engineering of antibodies and enzymes (1999) J. Mol. Recognit, 12, p. 198
Reymond, J.L., (2006) Enzyme Assays: High-throughput Screening, Genetic Selection and Fingerprinting, , Wiley-VCH Verlag GmbH and Co. KGaA: Weinheim
Min, D., Mrksich, M., Profiling kinase activities by using a peptide chip and mass spectrometry (2004) Angew. Chem., Int. Ed. Engl, 43, p. 5973
Babiak, P., Reymond, J., A high-throughput, low-volume enzyme assay on solid support (2005) Anal. Chem, 77, p. 373
Huber, W., Hoffman, F., A new strategy for improved secondary screening and lead optimization using high-resolution SPR characterization of compound-target interactions (2005) J. Mol. Recognit, 18, p. 273
Nedelkov, D., Nelson, R.W., Surface plasmon resonance mass spectrometry for protein analysis (2006) Methods Mol. Biol, 328, p. 131
Borch, J., Roepstorff, P., Screening for enzyme inhibitors by surface plasmon resonance combined with mass spectrometry (2004) Anal. Chem, 76, p. 5243
Hutchens, T., Yip, T.T., New desorption strategies for the mass spectrometric analysis of macromolecules (1993) Rapid Commun. Mass Spectrom, 7, p. 576
Caputo, E., Moharram, R., Martin, B.M., Methods for on-chip analysis (2003) Anal. Biochem, 321, p. 116
Merchant, M., Weinberger, S.R., Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (2000) Electrophoresis, 21, p. 1164
Griesser, H.J., Kingshott, P., McArthur, S.L., McLean, K.M., Kinsel, G.R., Timmons, R.B., Surface-MALDI mass spectrometry in biomaterials research (2004) Biomaterials, 25, p. 4861
Clarke, C.H., Buckley, J.A., Fung, E.T., SELDI-TOF-MS proteomics of breast cancer (2005) Clin. Chem. Lab. Med, 43, p. 1314
Bons, J.A.P., Wodzig, W.K.W.H., van Dieijen-Visser, M.P., Protein profiling as a diagnostic tool in clinical chemistry: A review (2005) Clin. Chem. Lab. Med, 43, p. 1281
Issaq, H.J., Conrads, T.P., Prieto, D.A., Tirumalai, R., Veenstra, T.D., SELDI-TOF MS for diagnostic proteomics (2003) Anal. Chem, 1, pp. 149A
Ge, Y., Gibbs, B.F., Masse, R., Complete chemical and enzymatic treatment of phosphorylated and glycosylated proteins on proteinchip arrays (2005) Anal. Chem, 77, p. 3644
Shen, Z., Go, E.P., Gamez, A., Apon, J.V., Fokin, V., Greig, M., Ventura, M., Siuzdak, G., A mass spectrometry plate reader: Monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform (2004) Chembiochem, 5, p. 921
Min, D., Tang, W., Mrksich, M., Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor (2004) Nat. Biotechnol, 22, p. 717
Bornsen, K.O., Gass, M.A.S., Bruin, G.J.M., von Adrichem, J.H.M., Biro, M.C., Kresbach, G.M., Ehrat, M., Influence of solvents and detergents on matrix-assisted laser desorption/ionization mass spectrometry measurements of proteins and oligonucleotides (1997) Rapid Commun. Mass Spectrom, 11, p. 603
Brockman, A.H., Dodd, B.S., Orlando, N., A desalting approach for MALDI-MS using on-probe hydrofobic self-assembled monolayers (1997) Anal. Chem, 69, p. 4716
Worral, T.A., Cotter, R.J., Woods, A.S., Purification of contaminated peptides on synthetic membrane surfaces for matrix-assisted laser desorption/ionization mass spectrometry (1998) Anal. Chem, 70, p. 750
Warren, M.E., Brockman, A.H., Orlando, R., On-probe solid-phase extraction/MALDI-MS using ion-pairing interactions for the cleanup of peptides and proteins (1998) Anal. Chem, 70, p. 3757
Xu, Y., Watson, J.T., Bruening, M.L., Patterned monolayer/polymer films for analysis of dilute or salt-contaminated protein samples by MALDI-MS (2003) Anal. Chem, 75, p. 185
Wang, Y., Xia, X., Guo, Y., Porous anodic alumina membrane as a sample support for MALDI-TOF MS analysis of salt-containing proteins (2005) J. Am. Soc. Mass Spectrom, 16, p. 1488
Smirnov, I.P., Zhu, X., Taylor, T., Huang, Y., Ross, P., Papayanopoulos, I.A., Martin, S.A., Pappin, D.J., Suppression of α-Cyano-4-hydroxycinnamic acid matrix clusters and reduction of chemical noise in MALDI-TOF mass spectrometry (2004) Anal. Chem, 76, p. 2958
Kim, J.-S., Kim, J.-Y., Kim, H.-J., Suppression of matrix clusters and enhancement of peptide signals in MALDI-TOF mass spectrometry using nitrilotriacetic acid (2005) Anal. Chem, 77, p. 7483
Newton, K.A., McLuckey, S.A., Generation and manipulation of Sodium cationized peptides in the gas phase (2004) J. Am. Soc. Mass Spectrom, 15, p. 607
Su, J., Mrksich, M., Using MALDI-TOF mass spectrometry to characterize interfacial reactions on self-assembled monolayers (2003) Langmuir, 19, p. 4867
Grasso, G., D'Agata, R., Rizzarelli, E., Spoto, G., D'Andrea, L., Pedone, C., Picardi, A., Yeo, K.J., Activity of anchored human matrix metalloproteinase-1 catalytic domain on au (111) surfaces monitored by ESI-MS (2005) J. Mass Spectrom, 40, p. 1565
Massova, I., Kotra, L.P., Fridman, R., Mobashery, S., Matrix metalloproteinases: Structures, evolution, and diversification (1998) FASEB J, 12, p. 1075
Coussens, L.M., Werb, Z., Matrix metalloproteinases and the development of cancer (1996) Chem. Biol, 3, p. 895
Koivunen, E., Arap, W., Valtanen, H., Rainisalo, A., Medina, O.P., Heikkilä, P., Kantor, C., Pasqualini, R., Tumor targeting with a selective gelatinase inhibitor (1999) Nat. Biotechnol, 17, p. 768
Farkas, E., Katz, Y., Bhusare, S., Reich, R., Röschenthaler, G., Königsmann, M., Breuer, E., Carbamoylphosphonate Based Matrix Metalloproteinase (MMP) inhibitor metal complexes-solution studies and stability constants. Towards a zinc selective binding group (2004) J. Biol. Inorg. Chem, 9, p. 307
Schneider, B.B., Lock, C., Covey, T.R., AP and vacuum MALDI on a QqLIT instrument (2005) J. Am. Soc. Mass Spectrom, 16, p. 176
Trimpin, S., Deinzer, M.L., Solvent-free MALDI-MS for the analysis of biological samples via a mini-ball mill approach (2005) J. Am. Soc. Mass Spectrom, 16, p. 542
Whitesides, G., Xia, Y., Soft lithography (1998) Angew. Chem., Int. Ed. Engl, 37, p. 550
Navratilova, I., Eisenstien, E., Myszka, D.G., Measuring long association phases using Biacore (2005) Anal. Biochem, 344, p. 295
Larsericsdotter, H., Oscarsson, S., Buijs, J., Structure, stability, and orientation of BSA adsorbed to silica (2005) J. Colloid Interface Sci, 289, p. 26
Tan, P.V., Laiko, V.V., Doroshenko, V.M., Atmospheric pressure MALDI with pulsed dynamic focusing for high-efficiency transmission of ions into a mass spectrometer (2004) Anal. Chem, 75, p. 2462
Bertini, I., Calderone, V., Cosenza, M., Fragai, M., Lee, Y.-M., Luchinat, C., Mangani, S., Turano, P., Conformational variability of matrix metalloproteinases: Beyond a single 3D structure (2005) Proc. Natl. Acad. Sci. U.S.A, 102, p. 5334
Buchardt, J., Schiodt, C.B., Krog-Jensen, C., Delaisse, J.-M., Foged, N.T., Meldal, M., Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors (2000) J. Comb. Chem, 2, p. 624
Feng, R., Castelhano, A.L., Billedeau, R., Yuan, Z., Study of noncovalent enzyme-inhibitor complexes and metal binding stoichiometry of matrilysin by electrospray ionization mass spectrometry (1995) J. Am. Soc. Mass Spectrom, 6, p. 1105
Sung, J.Y., Park, S.M., Lee, C.-H., Um, J.W., Lee, H.J., Kim, J., Oh, Y.J., Chung, K.C., Proteolytic cleavage of extracellular secreted a-synuclein via matrix metalloproteinases (2005) J. Biol. Chem, 280, pp. 25-216
Lauer-Fields, J.L., Nagase, H., Fields, G.B., Use of edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases (2000) J. Chromatogr., A, 890, p. 117
Gossas, T., Danielason, U.H., Characterization of Ca2+ interactions with matrix metallopeptidase-12: Implications for matrix metallopeptidase regulation (2006) Biochem. J, 398, p. 393
Willenbrock, F., Murphy, G., Phillips, I.R., Brocklehurst, K., The second zinc atom in the matrix metalloproteinase catalytic domain is absent in the full-length enzymes: A possible role for the C-terminal domain (1995) FEBS Lett, 358, p. 189
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In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases
Several different procedures are available for the immobilization of proteins on solid supports, as many advantages derive from this approach, such as the possibility to develop new protein solid-state assays. Enzymes that are anchored on gold surfaces can interact with several different molecules in a tag-free environment, opening the way to surface plasmon resonance (SPR) investigations. Nevertheless, it is often important to know the identity of the affinity-retained analyte, and mass spectrometric analysis, via its unique molecular mass identification, represents a very valuable complementary method. There are many pieces of evidence to suggest that matrix metalloproteinases (MMPs) are involved in normal and pathological processes, including embryogenesis, wound healing, inflammation, arthritis and cancer, but presumably also exhibiting other functions. The search for new inhibitors of MMI's has prompted research towards the development of new solid-state assays for the rapid evaluation of NIMP activity. We have already reported the possibility of measuring the activity of NIMP-1 anchored on solid support by coupling SPR with ESI-MS analysis. In this work, we show the in situ atmospheric pressure (AP) MALDI-MS characterization of MMPs anchored on a gold chip with known surface coverage. The study extends the MS analysis to different proteins, and sequence coverage is reported for different digestion and MS procedures. Copyright (c) 2006 John Wiley & Sons, Ltd.
Several different procedures are available for the immobilization of proteins on solid supports, as many advantages derive from this approach, such as the possibility to develop new protein solid-state assays. Enzymes that are anchored on gold surfaces can interact with several different molecules in a tag-free environment, opening the way to surface plasmon resonance (SPR) investigations. Nevertheless, it is often important to know the identity of the affinity-retained analyte, and mass spectrometric analysis, via its unique molecular mass identification, represents a very valuable complementary method. There are many pieces of evidence to suggest that matrix metalloproteinases (MMPs) are involved in normal and pathological processes, including embryogenesis, wound healing, inflammation, arthritis and cancer, but presumably also exhibiting other functions. The search for new inhibitors of MMI's has prompted research towards the development of new solid-state assays for the rapid evaluation of NIMP activity. We have already reported the possibility of measuring the activity of NIMP-1 anchored on solid support by coupling SPR with ESI-MS analysis. In this work, we show the in situ atmospheric pressure (AP) MALDI-MS characterization of MMPs anchored on a gold chip with known surface coverage. The study extends the MS analysis to different proteins, and sequence coverage is reported for different digestion and MS procedures. Copyright (c) 2006 John Wiley & Sons, Ltd.
In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases
No results. Nessun risultato. |
In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases
Squeglia F, Ruggiero A, Berisio R
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Trac Trends In Analytical Chemistry (ISSN: 0165-9936), 2011 Jun; 30(6): 856-863.
Impact Factor: 6.273
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Roviello GN, Di Gaetano S, Capasso D, Franco S, Crescenzo C, Bucci EM, Pedone C
* RNA-binding and viral reverse transcriptase inhibitory activity of a novel cationic diamino acid-based peptide (411 visite)
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Impact Factor: 5.248
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* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (506 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II (317 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011; 47(42): 11636-11638.
Impact Factor: 6.169
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Viparelli F, Monti SM, De Simone G, Innocenti A, Scozzafava A, Xu Y, Morel FMM, Supuran CT
* Inhibition Of The R1 Fragment Of The Cadmium-Containing Zeta-Class Carbonic Anhydrase From The Diatom Thalassiosira Weissflogii With Anions (299 visite)
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Impact Factor: 2.661
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Langella E, Pierre S, Ghattas W, Giorgi M, Réglier M, Saviano M, Esposito L, Hardré R
* Probing The Peptidylglycine Alpha-Hydroxylating Monooxygenase Active Site With Novel 4-Phenyl-3-Butenoic Acid Based Inhibitors (372 visite)
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Impact Factor: 3.306
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* Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (313 visite)
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Impact Factor: 2.661
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (421 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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* Molecular imaging of tumor microenvironment: Challenges and perspectives (545 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
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Impact Factor: 4.106
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Impact Factor: 2.773
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Impact Factor: 19.407
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Guler OO, De Simone G, Supuran CT
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Impact Factor: 4.63
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Giurato P, Candura A, Grasso G, Spoto G
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Impact Factor: 1.595
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Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321.
Impact Factor: 2.473
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Impact Factor: 3.411
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Impact Factor: 2.437
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Impact Factor: 4.504
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J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Curr Protein Pept Sci (ISSN: 1389-2037), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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* Ccarbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides With Selectivity For Targeting The Tumor Associated Isoforms Ix And Xii (443 visite)
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Impact Factor: 4.898
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Supuran CT, Di Fiore A, De Simone G
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Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors (361 visite)
Bioorg Med Chem Lett (ISSN: 1464-3405, 0960-894x, 1464-3405electronic), 2008 Apr 15; 18(8): 2669-2674.
Impact Factor: 2.531
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* Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (339 visite)
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Impact Factor: 2.531
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Impact Factor: 2.276
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
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Impact Factor: 4.898
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Impact Factor: 4.399
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* Atmospheric Pressure Laser Desorption Mass Spectrometry based methods for the study of traditional painting materials (202 visite)
Lasers Conserv Artworks Proc Int Conf Lacona Vii (ISSN: 9780-4154), 2008; N/D: 67-72.
Impact Factor: 0
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* Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (332 visite)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
Impact Factor: 4.399
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* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (377 visite)
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Impact Factor: 9.38
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (443 visite)
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Impact Factor: 6.44
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Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (304 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Sep 1; 17(15): 4201-4207.
Impact Factor: 2.604
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (381 visite)
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Impact Factor: 5.581
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (306 visite)
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
Impact Factor: 3.664
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Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
* Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (447 visite)
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Impact Factor: 4.895
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (519 visite)
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Impact Factor: 3.259
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De Simone G, Supuran CT
* Antiobesity carbonic anhydrase inhibitors (396 visite)
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Impact Factor: 4.325
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* The use of atmospheric pressure laser desorption mass spectrometry for the study of iron-gall ink (259 visite)
Appl Phys A (ISSN: 0947-8396), 2007; 89(1): 91-95.
Impact Factor: 1.857
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* The chemical synthesis of the GstI protein by NCL on a X-Met site (584 visite)
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Impact Factor: 2.48
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Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
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Impact Factor: 5.115
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De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT
* Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (422 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551.
Impact Factor: 5.115
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Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (374 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (292 visite)
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Impact Factor: 2.538
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
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J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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* Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (342 visite)
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Impact Factor: 3.415
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* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (306 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (450 visite)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
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Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (375 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (452 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (345 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
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* A substrate-induced switch in the reaction mechanism of a thermophilic esterase - Kinetic evidences and structural basis (370 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Feb 20; 279(8): 6815-6823.
Impact Factor: 6.355
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (419 visite)
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Impact Factor: 2.331
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Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (367 visite)
Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
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Cook JA, Kim SY, Teague D, Krishna MC, Pacelli R, Mitchell JB, Vodovotz Y, Nims RW, Christodoulou D, Miles AM, Grisham MB, Wink DA
Convenient colorimetric and fluorometric assays for S-nitrosothiols (371 visite)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 Jul 1; 238(2): 150-158.
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* Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials (194 visite)
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* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (265 visite)
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Galati C, Spinella N, Renna L, Milardi D, Attanasio F, Sciacca MFM, Bongiorno C
* Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology (377 visite)
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Auriemma F, De Rosa C, Malafronte A, Di Girolamo R, Santillo C, Gerelli Y, Fragneto G, Barker R, Pavone V, Maglio O, Lombardi A
* Nano-in-Nano Approach for Enzyme Immobilization Based on Block Copolymers (329 visite) (PDF 149 visite)
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Altug C, Gunes H, Nocentini A, Monti SM, Buonanno M, Supuran CT
* Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties (257 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2017 Feb 15; 25(4): 1456-1464.
Impact Factor: 2.881
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Angapelly S, Ramya PVS, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M
* Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors (221 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2017; 25(2): 539-544.
Impact Factor: 2.881
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Quero G, Consales M, Severino R, Vaiano P, Boniello A, Sandomenico A, Ruvo M, Borriello A, Diodato L, Zuppolini S, Giordano M, Nettore IC, Mazzarella C, Colao A, Macchia PE, Santorelli F, Cutolo A, Cusano A
* Long period fiber grating nano-optrode for cancer biomarker detection (280 visite) (PDF 193 visite)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2016 Feb 13; 80: 590-600.
Impact Factor: 7.78
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Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R
* Cationic porphyrins are tunable gatekeepers of the 20S proteasome (630 visite) (PDF 227 visite)
Chem Sci (ISSN: 2041-6520, 2041-6520linking, 2041-6520print), 2016; 7(2): 1286-1297.
Impact Factor: 8.668
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Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz HJ, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH
* Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke (288 visite)
J Cerebr Blood F Met (ISSN: 0271-678x), 2015 Nov; 35(11): 1711-1721.
Impact Factor: 4.929
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Alterio V, Langella E, De Simone G, Monti SM
* Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (437 visite)
Mar Drugs (ISSN: 1660-3397, 1660-3397linking), 2015 Mar 25; 13(4): 1688-1697.
Impact Factor: 3.345
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Monti SM, Supuran CT, De Simone G
* DPP-4 inhibitors: a patent review (2012 - 2014) (341 visite)
Expert Opin Ther Pat (ISSN: 1354-3776, 1744-7674electronic), 2015 Feb; 25(2): 209-236.
Impact Factor: 4.626
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (286 visite)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Ceruso M, Carta F, Osman SM, Alothman Z, Monti SM, Supuran CT
* Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties (330 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2015; 23(15): 4181-4187.
Impact Factor: 2.923
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (393 visite)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A
* Recent developments of carbonic anhydrase inhibitors as potential drugs (381 visite)
Biomed Res Int (ISSN: 2314-6133, 2314-6141), 2015; 2015: 174178-174178.
Impact Factor: 2.134
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Sandomenico A, Celentano V, D'Andrea LD, Palmieri G, Ruvo M
* Screening of beta-hairpin peptide-engrafted 1, 2, 3-triazoles to identify APEH enzyme inhibitors (364 visite)
Rsc Adv (ISSN: 2046-2069), 2015; 5(13): 9965-9972.
Impact Factor: 3.289
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Di Fiore A, Alterio V, Monti SM, De Simone G, D’Ambrosio K
* Thermostable carbonic anhydrases in biotechnological applications (412 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(7): 15456-15480.
Impact Factor: 3.257
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Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
* Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor (560 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2014 Jul 24; 57(14): 5965-5974.
Impact Factor: 5.447
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Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
* Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (351 visite)
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
Impact Factor: 2.332
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Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (388 visite)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (374 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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De Simone G, Alterio V, Supuran CT
* Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (384 visite)
Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
Impact Factor: 3.467
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Monti SM, Supuran CT, De Simone G
* Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013) (383 visite)
Expert Opin Ther Pat (ISSN: 1354-3776, 1744-7674electronic), 2013 Jun; 23(6): 737-749.
Impact Factor: 3.441
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Doti N, Raimondo D, Sabatella M, Ruvo M
* Identification of Protease Inhibitors by a Fast Fluorimetric Assay (381 visite)
Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2013 Jun; 54(2): 283-291.
Impact Factor: 2.275
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Maffei E, Midiri M, Russo V, Rengo M, Tedeschi C, Spagnolo P, Seitun S, Francone M, Guaricci AI, Carrabba N, Malagò R, Cuocolo A, Arcadi T, Catalano OA, Cademartiri F
* Rationale, design and methods of CTCA-PRORECAD (Computed Tomography Coronary Angiography Prognostic Registry for Coronary Artery Disease): A multicentre and multivendor registry (293 visite)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2013 Jun; 118(4): 591-607.
Impact Factor: 1.368
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Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
* A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (341 visite)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic), 2013 Apr 2; 52(14): 3926-3930.
Impact Factor: 11.336
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (516 visite)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (409 visite)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (467 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
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Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
* The mode of action of anticancer gold-based drugs: a structural perspective (316 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013; 49(86): 10100-10102.
Impact Factor: 6.718
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Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (457 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
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Berisio R
* Editorial: cell processes in bacterial diseases (372 visite)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
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De Simone G, Supuran CT
* (In)organic anions as carbonic anhydrase inhibitors (348 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2012 Jun; 111: 117-129.
Impact Factor: 3.197
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Alterio V, Langella E, Viparelli F, Vullo D, Ascione G, Dathan NA, Morel FM, Supuran CT, De Simone G, Monti SM
* Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii (374 visite)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1232-1241.
Impact Factor: 3.142
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Gringeri CV, Menchise V, Rizzitelli S, Cittadino E, Catanzaro V, Dati G, Chaabane L, Digilio G, Aime S
* Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases (440 visite)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2012 Mar; 7(2): 175-184.
Impact Factor: 2.872
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Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (338 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
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De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (341 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
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Monti SM, Maresca A, Viparelli F, Carta F, De Simone G, Muehlschlegel FA, Scozzafava A, Supuran CT
* Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata (343 visite)
Bioorg Med Chem Lett (ISSN: 0960-894x), 2012 Jan 15; 22(2): 859-862.
Impact Factor: 2.338
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Di Fiore A, Maresca A, Supuran CT, De Simone G
* Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (320 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
Impact Factor: 6.378
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (402 visite)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (392 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Milite C, Castellano S, Benedetti R, Tosco A, Ciliberti C, Vicidomini C, Boully L, Franci G, Altucci L, Mai A, Sbardella G
* Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs) (319 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2011 Jun 15; 19(12): 3690-3701.
Impact Factor: 2.921
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Spoto G, Grasso G
* Spatially resolved mass spectrometry in the study of art and archaeological objects (185 visite)
Trac Trends In Analytical Chemistry (ISSN: 0165-9936), 2011 Jun; 30(6): 856-863.
Impact Factor: 6.273
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Roviello GN, Di Gaetano S, Capasso D, Franco S, Crescenzo C, Bucci EM, Pedone C
* RNA-binding and viral reverse transcriptase inhibitory activity of a novel cationic diamino acid-based peptide (411 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2011 Apr 14; 54(7): 2095-2101.
Impact Factor: 5.248
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (506 visite)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Di Fiore A, Maresca A, Alterio V, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II (317 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011; 47(42): 11636-11638.
Impact Factor: 6.169
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Viparelli F, Monti SM, De Simone G, Innocenti A, Scozzafava A, Xu Y, Morel FMM, Supuran CT
* Inhibition Of The R1 Fragment Of The Cadmium-Containing Zeta-Class Carbonic Anhydrase From The Diatom Thalassiosira Weissflogii With Anions (299 visite)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Sep 15; 20(16): 4745-4748.
Impact Factor: 2.661
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Langella E, Pierre S, Ghattas W, Giorgi M, Réglier M, Saviano M, Esposito L, Hardré R
* Probing The Peptidylglycine Alpha-Hydroxylating Monooxygenase Active Site With Novel 4-Phenyl-3-Butenoic Acid Based Inhibitors (372 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2010 Sep 3; 5(9): 1568-1576.
Impact Factor: 3.306
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Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (313 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605.
Impact Factor: 2.661
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (421 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (545 visite)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (398 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (357 visite)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (507 visite)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Guler OO, De Simone G, Supuran CT
* Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (437 visite)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526.
Impact Factor: 4.63
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Giurato P, Candura A, Grasso G, Spoto G
* In situ identification of organic components of ink used in books from the 1900s by atmospheric pressure matrix assisted laser desorption ionization mass spectrometry (266 visite)
Appl Phys A (ISSN: 0947-8396), 2009 Nov; 97(2): 263-269.
Impact Factor: 1.595
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De Simone G, Scozzafava A, Supuran CT
* Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (304 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321.
Impact Factor: 2.473
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Grasso G, Rizzarelli E, Spoto G
* The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study (366 visite)
J Mass Spectrom (ISSN: 1096-9888, 1076-5174), 2009 May; 44(5): 735-741.
Impact Factor: 3.411
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Grasso G, Bush AI, D'Agata R, Rizzarelli E, Spoto G
* Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme (345 visite)
Eur Biophys J (ISSN: 1432-1017, 0175-7571), 2009 Apr; 38(4): 407-414.
Impact Factor: 2.437
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Grasso G, D'Urso L, Messina E, Cataldo F, Puglisi O, Spoto G, Compagnini G
* A mass spectrometry and surface enhanced Raman spectroscopy study of the interaction between linear carbon chains and noble metals (432 visite)
Carbon (ISSN: 0008-6223), 2009; 47(11): 2611-2619.
Impact Factor: 4.504
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (378 visite)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (477 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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D'Ambrosio K, Vitale R, Dogne J, Masereel B, Innocenti A, Scozzafava A, De Simone G, Supuran CT
* Ccarbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides With Selectivity For Targeting The Tumor Associated Isoforms Ix And Xii (443 visite)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2008 Jun 12; 51(11): 3230-3237.
Impact Factor: 4.898
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (414 visite)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors (361 visite)
Bioorg Med Chem Lett (ISSN: 1464-3405, 0960-894x, 1464-3405electronic), 2008 Apr 15; 18(8): 2669-2674.
Impact Factor: 2.531
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Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
* Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (339 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
Impact Factor: 2.531
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Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (339 visite)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (386 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (361 visite)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
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Licciardello MP, D'Agata R, Grasso G, Simone S, Spoto G
* Atmospheric Pressure Laser Desorption Mass Spectrometry based methods for the study of traditional painting materials (202 visite)
Lasers Conserv Artworks Proc Int Conf Lacona Vii (ISSN: 9780-4154), 2008; N/D: 67-72.
Impact Factor: 0
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Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
* Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (332 visite)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
Impact Factor: 4.399
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (377 visite)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (443 visite)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
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Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (304 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Sep 1; 17(15): 4201-4207.
Impact Factor: 2.604
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (381 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (306 visite)
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
Impact Factor: 3.664
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Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
* Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (447 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2007 Mar 22; 50(6): 1241-1253.
Impact Factor: 4.895
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (519 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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De Simone G, Supuran CT
* Antiobesity carbonic anhydrase inhibitors (396 visite)
Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
Impact Factor: 4.325
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D'Agata R, Grasso G, Parlato S, Simone S, Spoto G
* The use of atmospheric pressure laser desorption mass spectrometry for the study of iron-gall ink (259 visite)
Appl Phys A (ISSN: 0947-8396), 2007; 89(1): 91-95.
Impact Factor: 1.857
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Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
* The chemical synthesis of the GstI protein by NCL on a X-Met site (584 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Dec 5; 83(5): 508-518.
Impact Factor: 2.48
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Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (412 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
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De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT
* Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX (422 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Sep 7; 49(18): 5544-5551.
Impact Factor: 5.115
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Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (374 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (292 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
Impact Factor: 2.538
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (479 visite)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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Naddeo M, Vitagliano L, Russo A, Gotte G, D'Alessio G, Sorrentino S
* Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (342 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
Impact Factor: 3.415
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (306 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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Cozzolino R, Palladino P, Rossi F, Cali G, Benedetti E, Laccetti P
* Antineoplastic cyclic astin analogues kill tumour cells via caspase-mediated induction of apoptosis (450 visite)
Carcinogenesis (ISSN: 0143-3334), 2005 Apr; 26(4): 733-739.
Impact Factor: 5.108
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Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (375 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
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Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, Lambertini E, Penolazzi L, Nastruzzi C, Mischiati C, Piva R, Pedone C, Gambari R
* Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression (452 visite)
Curr Drug Targets (ISSN: 1389-4501), 2004 Nov; 5(8): 735-744.
Impact Factor: 4.104
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Sica F, Di Fiore A, Merlino A, Mazzarella L
* Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor (345 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Sep 27; 279(35): 36753-36760.
Impact Factor: 6.355
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De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G
* A substrate-induced switch in the reaction mechanism of a thermophilic esterase - Kinetic evidences and structural basis (370 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2004 Feb 20; 279(8): 6815-6823.
Impact Factor: 6.355
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (419 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (566 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (296 visite)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
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Gallo P, Rossi F, Saviano M, Pedone C, Colonna G, Ragone R
Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide (367 visite)
Journal Of Biochemistry (ISSN: 0021-924x), 1998 Nov; 124(5): 880-885.
Impact Factor: 2.189
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Cook JA, Kim SY, Teague D, Krishna MC, Pacelli R, Mitchell JB, Vodovotz Y, Nims RW, Christodoulou D, Miles AM, Grisham MB, Wink DA
Convenient colorimetric and fluorometric assays for S-nitrosothiols (371 visite)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 Jul 1; 238(2): 150-158.
Impact Factor: 2.017
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100 Records (98 escludendo Abstract e Conferenze).
Impact factor totale: 418.475 (411.796 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 409.858 (403.239 escludendo Abstract e Conferenze).
Impact factor totale: 418.475 (411.796 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 409.858 (403.239 escludendo Abstract e Conferenze).
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