Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (494 views visite)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Comparative Study, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Review,
Impact factor: 24.52, 5-year impact factor Impact factor a 5 anni: 26.723
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34648836983&partnerID=40&md5=2445a8b7daad027f5269ca9b66d38e90
Keywords Parole chiave: Acetylcarnitine, Amide, Arginine, Arginine Derivative, Bilirubin, Carbonate Dehydratase Ii, Carnosine, Curcumin, Cyclic Amp Responsive Element Binding Protein, Cyclic Gmp Derivative, Doxorubicin, Endothelial Nitric Oxide Synthase, Ferulic Acid, Heat Shock Protein, Heme Oxygenase, Hemoglobin, Hemoglobin Derivative, Imidazoline Derivative, Inducible Nitric Oxide Synthase, N(g) Nitroarginine Methyl Ester, Neuronal Nitric Oxide Synthase, Nitric Oxide Donor, Nitro Derivative, Ornithine Derivative, Protein Kinase B, Quinoxaline Derivative, Sildenafil, Thiol Derivative, Tumor Necrosis Factor, Alzheimer Disease, Antiinflammatory Activity, Antioxidant Activity, Brain Ischemia, Brain Region, Cell Survival, Central Nervous System, Chronic Fatigue Syndrome, Cognition, Cognitive Defect, Concentration (parameters), Dementia, Depression, Diabetic Neuropathy, Enzyme Localization, Fluid Balance, Human, Human Immunodeficiency Virus Infection, Huntington Chorea, Impotence, Multiple Sclerosis, Nerve Cell Necrosis, Nerve Cell Plasticity, Neuromodulation, Neuroprotection, Neurotoxicity, Neurotransmission, Nitrosative Stress, Nitrosylation, Nonhuman, Oxidation Reduction Reaction, Priority Journal, Protein Expression, Protein Family, Protein Secretion, Proteomics, Pulmonary Hypertension, Reperfusion Injury, Reproduction, Review, Signal Transduction, Sleep Waking Cycle, Somnolence, Animals, Neurodegenerative Diseases, Neuroprotective Agents, Neurotoxicity Syndromes, N (g) Nitroarginine Methyl Ester,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. calabres@unict.it
Institute of Pharmacology, Catholic University School of Medicine, Roma, Italy
Department of Internal Medicine, Catholic University School of Medicine, Roma, Italy
References Riferimenti:
Guix, F. X., Uribesalgo, I., Coma, M. & Munoz, F. J. The physiology and pathophysiology of nitric oxide in the brain. Prog. Neurobiol. 76, 126-152 (2005). A comprehensive review of NO functions in the brainRivier, C. Role of gaseous neurotransmitters in the hypothalamic- pituitary-adrenal axis. Ann. NY Acad. Sci. 933, 254-264 (2001). A useful paper for understanding the controversial action of NO in the regulation of the stress axisMcCann, S.M., The nitric oxide hypothesis of brain aging (1997) Exp. Gerontol, 32, pp. 431-44
Toda, N., Ayajiki, K., Okamura, T., Nitric oxide and penile erectile function (2005) Pharmacol. Ther, 106, pp. 233-266
Takahashi, T., Pathophysiological significance of neuronal nitric oxide synthase in the gastrointestinal tract (2003) J. Gastroenterol, 38, pp. 421-430
Currò, D., Preziosi, P., Non-adrenergic noncholinergic relaxation of the rat stomach (1998) Gen. Pharmacol, 31, pp. 697-703
Pacher, P., Beckman, J.S., Liaudet, L., Nitric oxide and peroxynitrite in health and disease (2007) Physiol. Rev, 87, pp. 315-424
Hirst, D.G., Robson, T., Nitrosative stress in cancer therapy (2007) Front. Biosci, 12, pp. 3406-3418
Ridnour, L.A., The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations (2004) Biol. Chem, 385, pp. 1-10
Sultana, R., Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach (2006) Neurobiol. Dis, 22, pp. 76-87
Castegna A. et al. Proteomic identification of nitrated proteins in Alzheimer's disease brain. J. Neurochem. 85, 1394-1401 (2003). This was the first proteomics study to identify nitrated proteins in the brain of patients with Alzheimer's diseaseBredt, D.S., Endogenous nitric oxide synthesis: Biological functions and pathophysiology (1999) Free Radic. Res, 31, pp. 577-596
Dawson, T. M. & Snyder, S. H. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J. Neurosci. 14, 5147-5159 (1994). This paper provides details on the distribution of nNOS in the CNS and PNSRodrigo, J., Localization of nitric oxide synthase in the adult rat brain (1994) Philos. Trans. R. Soc. Lond. B Biol. Sci, 345, pp. 175-221
Vincent, S.R., Kimura, H., Histochemical mapping of nitric oxide synthase in the rat brain (1992) Neuroscience, 46, pp. 755-784
Bredt, D.S., Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase (1991) Neuron, 7, pp. 615-624
De Giorgio, R., Nitric oxide producing neurons in the monkey and human digestive system (1994) J. Comp. Neurol, 342, pp. 619-627
Magee, T., Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract (1996) Biochem. Biophys. Res. Commun, 226, pp. 145-151
Calabrese, V., Butterfield, D.A., Scapagnini, G., Stella, A.M., Maines, M.D., Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: Relevance to brain aging, neurodegenerative disorders, and longevity (2006) Antioxid. Redox Signal, 8, pp. 444-477
Colasanti, M., Expression of a NOS-III-like protein in human astroglial cell culture (1998) Biochem. Biophys. Res. Commun, 252, pp. 552-555
Rajasekaran, M., Ex vivo expression of nitric oxide synthase isoforms (eNOS/iNOS) and calmodulin in human penile cavernosal cells (1998) J. Urol, 160, pp. 2210-2215
Arnold, W. P., Mittal, C. K., Katsuki, S. & Murad, F. Nitric oxide activates guanylate cyclase and increases guanosine 3?-5?-cyclic monophosphate levels in various tissue preparations. Proc. Natl Acad. Sci. USA 74, 3203-3207 (1977). A milestone paper about the ability of NO to activate sGCKrumenacker, J.S., Hanafy, K.A., Murad, F., Regulation of nitric oxide and soluble guanylyl cyclase (2004) Brain Res. Bull, 62, pp. 505-515
Nakane, M., Soluble guanylyl cyclase: Physiological role as an NO receptor and the potential molecular target for therapeutic application (2003) Clin. Chem. Lab. Med, 41, pp. 865-870
Uretsky, A.D., Weiss, B.L., Yunker, W.K., Chang, J.P., Nitric oxide produced by a novel nitric oxide synthase isoform is necessary for gonadotropin-releasing hormone-induced growth hormone secretion via a cGMP-dependent mechanism (2003) J. Neuroendocrinol, 15, pp. 667-676
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., Salvemini, D., Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors (2005) Pharmacol. Rev, 57, pp. 217-252
Motterlini, R., Green, C.J., Foresti, R., Regulation of heme oxygenase-1 by redox signals involving nitric oxide (2002) Antioxid. Redox Signal, 4, pp. 615-624
Contestabile, A., Ciani, E., Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation (2004) Neurochem. Int, 45, pp. 903-914
Riccio, A. et al. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol. Cell 21, 283-294 (2006). This study demonstrates that the NO pathway controls CREB-DNA binding and CRE-mediated gene expressionFoster, M.W., McMahon, T.J., Stamler, J.S., S-nitrosylation in health and disease (2003) Trends Mol. Med, 9, pp. 160-168
Garthwaite, J., Charles, S. L. & Chess-Williams, R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336, 385-388 (1988). A landmark paper that demonstrates that EDRF, the early name given to NO, is involved in neurotransmissionPalmer, R.M., Ferrige, A.G., Moncada, S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor (1987) Nature, 327, pp. 524-526
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E. & Chaudhuri, G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl Acad. Sci. USA 84, 9265-9269 (1987). A milestone paper that reveals the identity of EDRF as NOGarthwaite, J., Boulton, C.L., Nitric oxide signaling in the central nervous system (1995) Annu. Rev. Physiol, 57, pp. 683-706
Sanders, K.M., Ward, S.M., Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission (1992) Am. J. Physiol, 262, pp. G379-G392
Prast, H., Tran, M.H., Fischer, H., Philippu, A., Nitric oxide-induced release of acetylcholine in the nucleus accumbens: Role of cyclic GMP, glutamate, and GABA (1998) J. Neurochem, 71, pp. 266-273
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S., Whitton, P.S., Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo (1996) Brain Res, 717, pp. 196-199
Ohkuma, S., Katsura, M., Chen, D.Z., Narihara, H., Kuriyama, K., Nitric oxide-evoked [3H]γ-aminobutyric acid release is mediated by two distinct release mechanisms (1996) Brain Res. Mol. Brain Res, 36, pp. 137-144
Lonart, G., Wang, J., Johnson, K.M., Nitric oxide induces neurotransmitter release from hippocampal slices (1992) Eur. J. Pharmacol, 220, pp. 271-272
Lorrain, D.S., Hull, E.M., Nitric oxide increases dopamine and serotonin release in the medial preoptic area (1993) Neuroreport, 5, pp. 87-89
Kaehler, S.T., Singewald, N., Sinner, C., Philippu, A., Nitric oxide modulates the release of serotonin in the rat hypothalamus (1999) Brain Res, 835, pp. 346-349
Bon, C.L., Garthwaite, J., On the role of nitric oxide in hippocampal long-term potentiation (2003) J. Neurosci, 23, pp. 1941-1948
Boulton, C.L., Southam, E., Garthwaite, J., Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase (1995) Neuroscience, 69, pp. 699-703
Chien, W.L., Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1- benzylindazole (2003) Mol. Pharmacol, 63, pp. 1322-1328
Hars, B., Endogenous nitric oxide in the rat pons promotes sleep (1999) Brain Res, 816, pp. 209-219
Datta, S., Patterson, E.H., Siwek, D.F., Endogenous and exogenous nitric oxide in the pedunculopontine tegmentum induces sleep (1997) Synapse, 27, pp. 69-78
Cavas, M., Navarro, J.F., Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat (2006) Prog. Neuropsychopharmacol. Biol. Psychiatry, 30, pp. 56-67
Stern, J.E., Nitric oxide and homeostatic control: An intercellular signalling molecule contributing to autonomic and neuroendocrine integration? (2004) Prog. Biophys. Mol. Biol, 84, pp. 197-215
Toni, R., Malaguti, A., Benfenati, F., Martini, L., The human hypothalamus: A morpho-functional perspective (2004) J. Endocrinol. Invest, 27, pp. 73-94
Tsigos, C., Chrousos, G.P., Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress (2002) J. Psychosom. Res, 53, pp. 865-871
Barberis, C., Tribollet, E., Vasopressin and oxytocin receptors in the central nervous system (1996) Crit. Rev. Neurobiol, 10, pp. 119-154
Tringali, G., Aubry, J.M., Navarra, P., Pozzoli, G., Lamotrigine inhibits basal and Na+-stimulated, but not Ca2+-stimulated, release of corticotropin-releasing hormone from the rat hypothalamus (2006) Psychopharmacology (Berl.), 188, pp. 386-392
Costa, A., Trainer, P., Besser, M., Grossman, A., Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro (1993) Brain Res, 605, pp. 187-192
Yasin, S., Nitric oxide modulates the release of vasopressin from rat hypothalamic explants (1993) Endocrinology, 133, pp. 1466-1469
Nguyen, K.T., Exposure to acute stress induces brain interleukin-1β protein in the rat (1998) J. Neurosci, 18, pp. 2239-2246
Karanth, S., Lyson, K., McCann, S.M., Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami (1993) Proc. Natl Acad. Sci. USA, 90, pp. 3383-3387
Rivier, C., Role of nitric oxide in regulating the rat hypothalamic-pituitary-adrenal axis response to endotoxemia (2003) Ann. NY Acad. Sci, 992, pp. 72-85
Kadekaro, M., Nitric oxide modulation of the hypothalamo-neurohypophyseal system (2004) Braz. J. Med. Biol. Res, 37, pp. 441-450
Brann, D.W., Bhat, G.K., Lamar, C.A., Mahesh, V.B., Gaseous transmitters and neuroendocrine regulation (1997) Neuroendocrinology, 65, pp. 385-395
Argiolas, A., Melis, M.R., Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus (2005) Prog. Neurobiol, 76, pp. 1-21
Mancuso, C., Heme oxygenase and its products in the nervous system (2004) Antioxid. Redox Signal, 6, pp. 878-887
Mancuso, C., Inhibition of heme oxygenase in the central nervous system potentiates endotoxin-induced vasopressin release in the rat (1999) J. Neuroimmunol, 99, pp. 189-194
Mancuso, C. et al. Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function. Brain Res. Mol. Brain Res. 50, 267-276 (1997). This was the first paper to provide direct evidence that carbon monoxide is involved in the regulation of vasopressin release from rat hypothalamic explantsPozzoli, G., Carbon monoxide as a novel neuroendocrine modulator: Inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants (1994) Endocrinology, 135, pp. 2314-2317
Jaffrey, S.R., Erdjument-Bromage, H., Ferris, C.D., Tempst, P., Snyder, S.H., Protein S-nitrosylation: A physiological signal for neuronal nitric oxide (2001) Nature Cell Biol, 3, pp. 193-197
Choi, Y.B., Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation (2000) Nature Neurosci, 3, pp. 15-21
Lipton, S.A., Singel, D.J., Stamler, J.S., Nitric oxide in the central nervous system (1994) Prog. Brain Res, 103, pp. 359-364
Mungrue, I.N., Bredt, D.S., nNOS at a glance: Implications for brain and brawn (2004) Cell Sci, 117, pp. 2627-2629
Melino, G., S-nitrosylation regulates apoptosis (1997) Nature, 388, pp. 432-433
Liu, L. & Stamler, J. S. NO: an inhibitor of cell death. Cell Death Differ. 6, 937-942 (1999)Mannick, J.B., S-Nitrosylation of mitochondrial caspases (2001) J. Cell Biol, 154, pp. 1111-1116
Tenneti, L., D'Emilia, D.M., Lipton, S.A., Suppression of neuronal apoptosis by S-nitrosylation of caspases (1997) Neurosci. Lett, 236, pp. 139-142
Zhou, P., Qian, L., Iadecola, C., Nitric oxide inhibits caspase activation and apoptotic morphology but does not rescue neuronal death (2005) J. Cereb. Blood Flow Metab, 25, pp. 348-357
Kitamura, Y., In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: Possible involvement of nitric oxide production from inducible nitric oxide synthase (1998) Glia, 22, pp. 138-148
Mancuso, C., Bonsignore, A., Di Stasio, E., Mordente, A. & Motterlini, R. Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide. Biochem. Pharmacol. 66, 2355-2363 (2003). In this paper, the authors describe the ability of bilirubin to interact with S-nitrosothiolsGood, P.F., Hsu, A., Werner, P., Perl, D.P., Olanow, C.W., Protein nitration in Parkinson's disease (1998) J. Neuropathol. Exp. Neurol, 57, pp. 338-342
Mancuso, C., Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders (2007) Front. Biosci, 12, pp. 1107-1123
Dalle-Donne, I., Scaloni, A. & Butterfield, D. A. (Eds) Redox Proteomics: From Protein Modifications to Cellular Dysfunctions and Diseases (John Wiley & Sons, New Jersey, 2006). A comprehensive treatise on the identification of oxidatively modified proteins in health and diseaseCastegna, A., Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: Dihydropyrimidinase- related protein 2, α-enolase and heat shock cognate 71 (2002) J. Neurochem, 82, pp. 1524-1532
Messier, C., Gagnon, M., Glucose regulation and brain aging (2000) J. Nutr. Health Aging, 4, pp. 208-213
Vanhanen, M., Soininen, H., Glucose intolerance, cognitive impairment and Alzheimer's disease (1998) Curr. Opin. Neurol, 11, pp. 673-677
Ojika, K., Tsugu, Y., Mitake, S., Otsuka, Y., Katada, E., NMDA receptor activation enhances the release of a cholinergic differentiation peptide (HCNP) from hippocampal neurons in vitro (1998) Brain Res. Dev. Brain Res, 106, pp. 173-180
Rossor, M.N., The substantia innominata in Alzheimer's disease: An histochemical and biochemical study of cholinergic marker enzymes (1982) Neurosci. Lett, 28, pp. 217-222
Giacobini, E., Cholinergic function and Alzheimer's disease (2003) Int. J. Geriatr. Psychiatry, 18, pp. S1-S5
Sun, M.K., Alkon, D.L., Carbonic anhydrase gating of attention: Memory therapy and enhancement (2002) Trends Pharmacol. Sci, 23, pp. 83-89
Chuang, D.M., Hough, C., Senatorov, V.V., Glyceraldehyde-3- phosphate dehydrogenase, apoptosis, and neurodegenerative diseases (2005) Annu. Rev. Pharmacol. Toxicol, 45, pp. 269-290
Browne, S.E., Beal, M.F., Oxidative damage in Huntington's disease pathogenesis (2006) Antioxid. Redox Signal, 8, pp. 2061-2073
Gu, Z., S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death (2002) Science, 297, pp. 1186-1190
Yong, V.W., Power, C., Forsyth, P., Edwards, D.R., Metalloproteinases in biology and pathology of the nervous system (2001) Nature Rev. Neurosci, 2, pp. 502-511
Yao, D., Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity (2004) Proc. Natl Acad. Sci. USA, 101, pp. 10810-10814
Chung, K.K., S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function (2004) Science, 304, pp. 1328-1331
Hara, M. R. et al. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc. Natl Acad. Sci. USA 103, 3887-3889 (2006). This paper describes a GAPDH-SIAH1-mediated pathway for cell death and unravels a new mechanism of action for selegiline, a drug used in the treatment of Parkinson's diseaseUehara, T., S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration (2006) Nature, 441, pp. 513-517
Burnett, A.L., The role of nitric oxide in erectile dysfunction: Implications for medical therapy (2006) J. Clin. Hypertens. (Greenwich), 8 (SUPPL. 4), pp. 53-62
Redington, A.E., Modulation of nitric oxide pathways: Therapeutic potential in asthma and chronic obstructive pulmonary disease (2006) Eur. J. Pharmacol, 533, pp. 263-276
Griffiths, M.J., Evans, T.W., Inhaled nitric oxide therapy in adults (2005) N. Engl. J. Med, 353, pp. 2683-2695
Hemnes, A.R., Champion, H.C., Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension (2006) Expert Rev. Cardiovasc. Ther, 4, pp. 293-300
Butterfield, D., Nutritional approaches to combat oxidative stress in Alzheimer's disease (2002) J. Nutr. Biochem, 13, p. 444
Scapagnini, G., Curcumin activates defensive genes and protects neurons against oxidative stress (2006) Antioxid. Redox Signal, 8, pp. 395-403
Kanski, J., Aksenova, M., Stoyanova, A., Butterfield, D.A., Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: Structure-activity studies (2002) J. Nutr. Biochem, 13, pp. 273-281
Kim, H.S., Inhibitory effects of long-term administration of ferulic acid on microglial activation induced by intracerebroventricular injection of β-amyloid peptide (1-42) in mice (2004) Biol. Pharm. Bull, 27, pp. 120-121
Sultana, R., Ravagna, A., Mohmmad-Abdul, H., Calabrese, V., Butterfield, D.A., Ferulic acid ethyl ester protects neurons against amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity: Relationship to antioxidant activity (2005) J. Neurochem, 92, pp. 749-758
Calabrese, V., Giuffrida Stella, A.M., Calvani, M., Butterfield, D.A., Acetylcarnitine and cellular stress response: Roles in nutritional redox homeostasis and regulation of longevity genes (2006) J. Nutr. Biochem, 17, pp. 73-88
Calabrese, V., Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: Evidence for a protective role of acetylcarnitine (2003) Neurochem. Res, 28, pp. 1321-1328
Abdul, H.M., Calabrese, V., Calvani, M., Butterfield, D.A., Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-β peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease (2006) J. Neurosci. Res, 84, pp. 398-408
De Marchis, S., Modena, C., Peretto, P., Giffard, C., Fasolo, A., Carnosine-like immunoreactivity in the central nervous system of rats during postnatal development (2000) J. Comp. Neurol, 426, pp. 378-390
Calabrese, V., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem. Res, 30, pp. 797-807
Preston, J.E., Hipkiss, A.R., Himsworth, D.T., Romero, I.A., Abbott, J.N., Toxic effects of β-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and β-alanine (1998) Neurosci. Lett, 242, pp. 105-108
Hipkiss, A.R., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann. NY Acad. Sci, 854, pp. 37-53
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell. Mol. Life Sci, 59, pp. 546-551
Joshi, G., Glutathione elevation by ?-glutamylcysteine ethyl ester as a potential therapeutic strategy towards preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implications for chemobrain (2007) J. Neurosci. Res, 85, pp. 497-503
Tangpong, J., Adriamycin-induced, TNF-?-mediated central nervous system toxicity (2006) Neurobiol. Dis, 23, pp. 127-139
Silverman, D.H., Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy (2007) Breast Cancer Res. Treat, 103, pp. 303-311
Rahman, I., Biswas, S.K., Kirkham, P.A., Regulation of inflammation and redox signalling by dietary polyphenols (2006) Biochem. Pharmacol, 72, pp. 1439-1452
Sultana, R., Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: A regional study (2007) J. Cell. Mol. Med, 11, pp. 839-851
Butterfield, D. A. et al. Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiol. Dis. 22, 223-232 (2006). This was the first paper to describe proteomicsidentified oxidatively modified brain proteins in mild cognitive impairment, a precursor to Alzheimer's diseaseSalerno, L., Sorrenti, V., Di Giacomo, C., Romeo, G. & Siracusa, M. A. Progress in the development of selective nitric oxide synthase (NOS) inhibitors. Curr. Pharm. Des. 8, 177-200 (2002). This paper provides useful information about the selectivity of several NOS inhibitorsMejia-Garcia, T.A., Paes-de-Carvalho, R., Nitric oxide regulates cell survival in purified cultures of avian retinal neurons: Involvement of multiple transduction pathways (2007) J. Neurochem, 100, pp. 382-394
Privalle, C., Talarico, T., Keng, T., DeAngelo, J., Pyridoxalated hemoglobin polyoxyethylene: A nitric oxide scavenger with antioxidant activity for the treatment of nitric oxide-induced shock (2000) Free Radic. Biol. Med, 28, pp. 1507-1517
Kaur, H., Interaction of bilirubin and biliverdin with reactive nitrogen species (2003) FEBS Lett, 543, pp. 113-119
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Comparative Study, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Review,
Impact factor: 24.52, 5-year impact factor Impact factor a 5 anni: 26.723
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34648836983&partnerID=40&md5=2445a8b7daad027f5269ca9b66d38e90
Keywords Parole chiave: Acetylcarnitine, Amide, Arginine, Arginine Derivative, Bilirubin, Carbonate Dehydratase Ii, Carnosine, Curcumin, Cyclic Amp Responsive Element Binding Protein, Cyclic Gmp Derivative, Doxorubicin, Endothelial Nitric Oxide Synthase, Ferulic Acid, Heat Shock Protein, Heme Oxygenase, Hemoglobin, Hemoglobin Derivative, Imidazoline Derivative, Inducible Nitric Oxide Synthase, N(g) Nitroarginine Methyl Ester, Neuronal Nitric Oxide Synthase, Nitric Oxide Donor, Nitro Derivative, Ornithine Derivative, Protein Kinase B, Quinoxaline Derivative, Sildenafil, Thiol Derivative, Tumor Necrosis Factor, Alzheimer Disease, Antiinflammatory Activity, Antioxidant Activity, Brain Ischemia, Brain Region, Cell Survival, Central Nervous System, Chronic Fatigue Syndrome, Cognition, Cognitive Defect, Concentration (parameters), Dementia, Depression, Diabetic Neuropathy, Enzyme Localization, Fluid Balance, Human, Human Immunodeficiency Virus Infection, Huntington Chorea, Impotence, Multiple Sclerosis, Nerve Cell Necrosis, Nerve Cell Plasticity, Neuromodulation, Neuroprotection, Neurotoxicity, Neurotransmission, Nitrosative Stress, Nitrosylation, Nonhuman, Oxidation Reduction Reaction, Priority Journal, Protein Expression, Protein Family, Protein Secretion, Proteomics, Pulmonary Hypertension, Reperfusion Injury, Reproduction, Review, Signal Transduction, Sleep Waking Cycle, Somnolence, Animals, Neurodegenerative Diseases, Neuroprotective Agents, Neurotoxicity Syndromes, N (g) Nitroarginine Methyl Ester,
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. calabres@unict.it
Institute of Pharmacology, Catholic University School of Medicine, Roma, Italy
Department of Internal Medicine, Catholic University School of Medicine, Roma, Italy
References Riferimenti:
Guix, F. X., Uribesalgo, I., Coma, M. & Munoz, F. J. The physiology and pathophysiology of nitric oxide in the brain. Prog. Neurobiol. 76, 126-152 (2005). A comprehensive review of NO functions in the brainRivier, C. Role of gaseous neurotransmitters in the hypothalamic- pituitary-adrenal axis. Ann. NY Acad. Sci. 933, 254-264 (2001). A useful paper for understanding the controversial action of NO in the regulation of the stress axisMcCann, S.M., The nitric oxide hypothesis of brain aging (1997) Exp. Gerontol, 32, pp. 431-44
Toda, N., Ayajiki, K., Okamura, T., Nitric oxide and penile erectile function (2005) Pharmacol. Ther, 106, pp. 233-266
Takahashi, T., Pathophysiological significance of neuronal nitric oxide synthase in the gastrointestinal tract (2003) J. Gastroenterol, 38, pp. 421-430
Currò, D., Preziosi, P., Non-adrenergic noncholinergic relaxation of the rat stomach (1998) Gen. Pharmacol, 31, pp. 697-703
Pacher, P., Beckman, J.S., Liaudet, L., Nitric oxide and peroxynitrite in health and disease (2007) Physiol. Rev, 87, pp. 315-424
Hirst, D.G., Robson, T., Nitrosative stress in cancer therapy (2007) Front. Biosci, 12, pp. 3406-3418
Ridnour, L.A., The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations (2004) Biol. Chem, 385, pp. 1-10
Sultana, R., Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach (2006) Neurobiol. Dis, 22, pp. 76-87
Castegna A. et al. Proteomic identification of nitrated proteins in Alzheimer's disease brain. J. Neurochem. 85, 1394-1401 (2003). This was the first proteomics study to identify nitrated proteins in the brain of patients with Alzheimer's diseaseBredt, D.S., Endogenous nitric oxide synthesis: Biological functions and pathophysiology (1999) Free Radic. Res, 31, pp. 577-596
Dawson, T. M. & Snyder, S. H. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J. Neurosci. 14, 5147-5159 (1994). This paper provides details on the distribution of nNOS in the CNS and PNSRodrigo, J., Localization of nitric oxide synthase in the adult rat brain (1994) Philos. Trans. R. Soc. Lond. B Biol. Sci, 345, pp. 175-221
Vincent, S.R., Kimura, H., Histochemical mapping of nitric oxide synthase in the rat brain (1992) Neuroscience, 46, pp. 755-784
Bredt, D.S., Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase (1991) Neuron, 7, pp. 615-624
De Giorgio, R., Nitric oxide producing neurons in the monkey and human digestive system (1994) J. Comp. Neurol, 342, pp. 619-627
Magee, T., Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract (1996) Biochem. Biophys. Res. Commun, 226, pp. 145-151
Calabrese, V., Butterfield, D.A., Scapagnini, G., Stella, A.M., Maines, M.D., Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: Relevance to brain aging, neurodegenerative disorders, and longevity (2006) Antioxid. Redox Signal, 8, pp. 444-477
Colasanti, M., Expression of a NOS-III-like protein in human astroglial cell culture (1998) Biochem. Biophys. Res. Commun, 252, pp. 552-555
Rajasekaran, M., Ex vivo expression of nitric oxide synthase isoforms (eNOS/iNOS) and calmodulin in human penile cavernosal cells (1998) J. Urol, 160, pp. 2210-2215
Arnold, W. P., Mittal, C. K., Katsuki, S. & Murad, F. Nitric oxide activates guanylate cyclase and increases guanosine 3?-5?-cyclic monophosphate levels in various tissue preparations. Proc. Natl Acad. Sci. USA 74, 3203-3207 (1977). A milestone paper about the ability of NO to activate sGCKrumenacker, J.S., Hanafy, K.A., Murad, F., Regulation of nitric oxide and soluble guanylyl cyclase (2004) Brain Res. Bull, 62, pp. 505-515
Nakane, M., Soluble guanylyl cyclase: Physiological role as an NO receptor and the potential molecular target for therapeutic application (2003) Clin. Chem. Lab. Med, 41, pp. 865-870
Uretsky, A.D., Weiss, B.L., Yunker, W.K., Chang, J.P., Nitric oxide produced by a novel nitric oxide synthase isoform is necessary for gonadotropin-releasing hormone-induced growth hormone secretion via a cGMP-dependent mechanism (2003) J. Neuroendocrinol, 15, pp. 667-676
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., Salvemini, D., Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors (2005) Pharmacol. Rev, 57, pp. 217-252
Motterlini, R., Green, C.J., Foresti, R., Regulation of heme oxygenase-1 by redox signals involving nitric oxide (2002) Antioxid. Redox Signal, 4, pp. 615-624
Contestabile, A., Ciani, E., Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation (2004) Neurochem. Int, 45, pp. 903-914
Riccio, A. et al. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol. Cell 21, 283-294 (2006). This study demonstrates that the NO pathway controls CREB-DNA binding and CRE-mediated gene expressionFoster, M.W., McMahon, T.J., Stamler, J.S., S-nitrosylation in health and disease (2003) Trends Mol. Med, 9, pp. 160-168
Garthwaite, J., Charles, S. L. & Chess-Williams, R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336, 385-388 (1988). A landmark paper that demonstrates that EDRF, the early name given to NO, is involved in neurotransmissionPalmer, R.M., Ferrige, A.G., Moncada, S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor (1987) Nature, 327, pp. 524-526
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E. & Chaudhuri, G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl Acad. Sci. USA 84, 9265-9269 (1987). A milestone paper that reveals the identity of EDRF as NOGarthwaite, J., Boulton, C.L., Nitric oxide signaling in the central nervous system (1995) Annu. Rev. Physiol, 57, pp. 683-706
Sanders, K.M., Ward, S.M., Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission (1992) Am. J. Physiol, 262, pp. G379-G392
Prast, H., Tran, M.H., Fischer, H., Philippu, A., Nitric oxide-induced release of acetylcholine in the nucleus accumbens: Role of cyclic GMP, glutamate, and GABA (1998) J. Neurochem, 71, pp. 266-273
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S., Whitton, P.S., Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo (1996) Brain Res, 717, pp. 196-199
Ohkuma, S., Katsura, M., Chen, D.Z., Narihara, H., Kuriyama, K., Nitric oxide-evoked [3H]γ-aminobutyric acid release is mediated by two distinct release mechanisms (1996) Brain Res. Mol. Brain Res, 36, pp. 137-144
Lonart, G., Wang, J., Johnson, K.M., Nitric oxide induces neurotransmitter release from hippocampal slices (1992) Eur. J. Pharmacol, 220, pp. 271-272
Lorrain, D.S., Hull, E.M., Nitric oxide increases dopamine and serotonin release in the medial preoptic area (1993) Neuroreport, 5, pp. 87-89
Kaehler, S.T., Singewald, N., Sinner, C., Philippu, A., Nitric oxide modulates the release of serotonin in the rat hypothalamus (1999) Brain Res, 835, pp. 346-349
Bon, C.L., Garthwaite, J., On the role of nitric oxide in hippocampal long-term potentiation (2003) J. Neurosci, 23, pp. 1941-1948
Boulton, C.L., Southam, E., Garthwaite, J., Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase (1995) Neuroscience, 69, pp. 699-703
Chien, W.L., Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1- benzylindazole (2003) Mol. Pharmacol, 63, pp. 1322-1328
Hars, B., Endogenous nitric oxide in the rat pons promotes sleep (1999) Brain Res, 816, pp. 209-219
Datta, S., Patterson, E.H., Siwek, D.F., Endogenous and exogenous nitric oxide in the pedunculopontine tegmentum induces sleep (1997) Synapse, 27, pp. 69-78
Cavas, M., Navarro, J.F., Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat (2006) Prog. Neuropsychopharmacol. Biol. Psychiatry, 30, pp. 56-67
Stern, J.E., Nitric oxide and homeostatic control: An intercellular signalling molecule contributing to autonomic and neuroendocrine integration? (2004) Prog. Biophys. Mol. Biol, 84, pp. 197-215
Toni, R., Malaguti, A., Benfenati, F., Martini, L., The human hypothalamus: A morpho-functional perspective (2004) J. Endocrinol. Invest, 27, pp. 73-94
Tsigos, C., Chrousos, G.P., Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress (2002) J. Psychosom. Res, 53, pp. 865-871
Barberis, C., Tribollet, E., Vasopressin and oxytocin receptors in the central nervous system (1996) Crit. Rev. Neurobiol, 10, pp. 119-154
Tringali, G., Aubry, J.M., Navarra, P., Pozzoli, G., Lamotrigine inhibits basal and Na+-stimulated, but not Ca2+-stimulated, release of corticotropin-releasing hormone from the rat hypothalamus (2006) Psychopharmacology (Berl.), 188, pp. 386-392
Costa, A., Trainer, P., Besser, M., Grossman, A., Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro (1993) Brain Res, 605, pp. 187-192
Yasin, S., Nitric oxide modulates the release of vasopressin from rat hypothalamic explants (1993) Endocrinology, 133, pp. 1466-1469
Nguyen, K.T., Exposure to acute stress induces brain interleukin-1β protein in the rat (1998) J. Neurosci, 18, pp. 2239-2246
Karanth, S., Lyson, K., McCann, S.M., Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami (1993) Proc. Natl Acad. Sci. USA, 90, pp. 3383-3387
Rivier, C., Role of nitric oxide in regulating the rat hypothalamic-pituitary-adrenal axis response to endotoxemia (2003) Ann. NY Acad. Sci, 992, pp. 72-85
Kadekaro, M., Nitric oxide modulation of the hypothalamo-neurohypophyseal system (2004) Braz. J. Med. Biol. Res, 37, pp. 441-450
Brann, D.W., Bhat, G.K., Lamar, C.A., Mahesh, V.B., Gaseous transmitters and neuroendocrine regulation (1997) Neuroendocrinology, 65, pp. 385-395
Argiolas, A., Melis, M.R., Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus (2005) Prog. Neurobiol, 76, pp. 1-21
Mancuso, C., Heme oxygenase and its products in the nervous system (2004) Antioxid. Redox Signal, 6, pp. 878-887
Mancuso, C., Inhibition of heme oxygenase in the central nervous system potentiates endotoxin-induced vasopressin release in the rat (1999) J. Neuroimmunol, 99, pp. 189-194
Mancuso, C. et al. Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function. Brain Res. Mol. Brain Res. 50, 267-276 (1997). This was the first paper to provide direct evidence that carbon monoxide is involved in the regulation of vasopressin release from rat hypothalamic explantsPozzoli, G., Carbon monoxide as a novel neuroendocrine modulator: Inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants (1994) Endocrinology, 135, pp. 2314-2317
Jaffrey, S.R., Erdjument-Bromage, H., Ferris, C.D., Tempst, P., Snyder, S.H., Protein S-nitrosylation: A physiological signal for neuronal nitric oxide (2001) Nature Cell Biol, 3, pp. 193-197
Choi, Y.B., Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation (2000) Nature Neurosci, 3, pp. 15-21
Lipton, S.A., Singel, D.J., Stamler, J.S., Nitric oxide in the central nervous system (1994) Prog. Brain Res, 103, pp. 359-364
Mungrue, I.N., Bredt, D.S., nNOS at a glance: Implications for brain and brawn (2004) Cell Sci, 117, pp. 2627-2629
Melino, G., S-nitrosylation regulates apoptosis (1997) Nature, 388, pp. 432-433
Liu, L. & Stamler, J. S. NO: an inhibitor of cell death. Cell Death Differ. 6, 937-942 (1999)Mannick, J.B., S-Nitrosylation of mitochondrial caspases (2001) J. Cell Biol, 154, pp. 1111-1116
Tenneti, L., D'Emilia, D.M., Lipton, S.A., Suppression of neuronal apoptosis by S-nitrosylation of caspases (1997) Neurosci. Lett, 236, pp. 139-142
Zhou, P., Qian, L., Iadecola, C., Nitric oxide inhibits caspase activation and apoptotic morphology but does not rescue neuronal death (2005) J. Cereb. Blood Flow Metab, 25, pp. 348-357
Kitamura, Y., In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: Possible involvement of nitric oxide production from inducible nitric oxide synthase (1998) Glia, 22, pp. 138-148
Mancuso, C., Bonsignore, A., Di Stasio, E., Mordente, A. & Motterlini, R. Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide. Biochem. Pharmacol. 66, 2355-2363 (2003). In this paper, the authors describe the ability of bilirubin to interact with S-nitrosothiolsGood, P.F., Hsu, A., Werner, P., Perl, D.P., Olanow, C.W., Protein nitration in Parkinson's disease (1998) J. Neuropathol. Exp. Neurol, 57, pp. 338-342
Mancuso, C., Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders (2007) Front. Biosci, 12, pp. 1107-1123
Dalle-Donne, I., Scaloni, A. & Butterfield, D. A. (Eds) Redox Proteomics: From Protein Modifications to Cellular Dysfunctions and Diseases (John Wiley & Sons, New Jersey, 2006). A comprehensive treatise on the identification of oxidatively modified proteins in health and diseaseCastegna, A., Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: Dihydropyrimidinase- related protein 2, α-enolase and heat shock cognate 71 (2002) J. Neurochem, 82, pp. 1524-1532
Messier, C., Gagnon, M., Glucose regulation and brain aging (2000) J. Nutr. Health Aging, 4, pp. 208-213
Vanhanen, M., Soininen, H., Glucose intolerance, cognitive impairment and Alzheimer's disease (1998) Curr. Opin. Neurol, 11, pp. 673-677
Ojika, K., Tsugu, Y., Mitake, S., Otsuka, Y., Katada, E., NMDA receptor activation enhances the release of a cholinergic differentiation peptide (HCNP) from hippocampal neurons in vitro (1998) Brain Res. Dev. Brain Res, 106, pp. 173-180
Rossor, M.N., The substantia innominata in Alzheimer's disease: An histochemical and biochemical study of cholinergic marker enzymes (1982) Neurosci. Lett, 28, pp. 217-222
Giacobini, E., Cholinergic function and Alzheimer's disease (2003) Int. J. Geriatr. Psychiatry, 18, pp. S1-S5
Sun, M.K., Alkon, D.L., Carbonic anhydrase gating of attention: Memory therapy and enhancement (2002) Trends Pharmacol. Sci, 23, pp. 83-89
Chuang, D.M., Hough, C., Senatorov, V.V., Glyceraldehyde-3- phosphate dehydrogenase, apoptosis, and neurodegenerative diseases (2005) Annu. Rev. Pharmacol. Toxicol, 45, pp. 269-290
Browne, S.E., Beal, M.F., Oxidative damage in Huntington's disease pathogenesis (2006) Antioxid. Redox Signal, 8, pp. 2061-2073
Gu, Z., S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death (2002) Science, 297, pp. 1186-1190
Yong, V.W., Power, C., Forsyth, P., Edwards, D.R., Metalloproteinases in biology and pathology of the nervous system (2001) Nature Rev. Neurosci, 2, pp. 502-511
Yao, D., Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity (2004) Proc. Natl Acad. Sci. USA, 101, pp. 10810-10814
Chung, K.K., S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function (2004) Science, 304, pp. 1328-1331
Hara, M. R. et al. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc. Natl Acad. Sci. USA 103, 3887-3889 (2006). This paper describes a GAPDH-SIAH1-mediated pathway for cell death and unravels a new mechanism of action for selegiline, a drug used in the treatment of Parkinson's diseaseUehara, T., S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration (2006) Nature, 441, pp. 513-517
Burnett, A.L., The role of nitric oxide in erectile dysfunction: Implications for medical therapy (2006) J. Clin. Hypertens. (Greenwich), 8 (SUPPL. 4), pp. 53-62
Redington, A.E., Modulation of nitric oxide pathways: Therapeutic potential in asthma and chronic obstructive pulmonary disease (2006) Eur. J. Pharmacol, 533, pp. 263-276
Griffiths, M.J., Evans, T.W., Inhaled nitric oxide therapy in adults (2005) N. Engl. J. Med, 353, pp. 2683-2695
Hemnes, A.R., Champion, H.C., Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension (2006) Expert Rev. Cardiovasc. Ther, 4, pp. 293-300
Butterfield, D., Nutritional approaches to combat oxidative stress in Alzheimer's disease (2002) J. Nutr. Biochem, 13, p. 444
Scapagnini, G., Curcumin activates defensive genes and protects neurons against oxidative stress (2006) Antioxid. Redox Signal, 8, pp. 395-403
Kanski, J., Aksenova, M., Stoyanova, A., Butterfield, D.A., Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: Structure-activity studies (2002) J. Nutr. Biochem, 13, pp. 273-281
Kim, H.S., Inhibitory effects of long-term administration of ferulic acid on microglial activation induced by intracerebroventricular injection of β-amyloid peptide (1-42) in mice (2004) Biol. Pharm. Bull, 27, pp. 120-121
Sultana, R., Ravagna, A., Mohmmad-Abdul, H., Calabrese, V., Butterfield, D.A., Ferulic acid ethyl ester protects neurons against amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity: Relationship to antioxidant activity (2005) J. Neurochem, 92, pp. 749-758
Calabrese, V., Giuffrida Stella, A.M., Calvani, M., Butterfield, D.A., Acetylcarnitine and cellular stress response: Roles in nutritional redox homeostasis and regulation of longevity genes (2006) J. Nutr. Biochem, 17, pp. 73-88
Calabrese, V., Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: Evidence for a protective role of acetylcarnitine (2003) Neurochem. Res, 28, pp. 1321-1328
Abdul, H.M., Calabrese, V., Calvani, M., Butterfield, D.A., Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-β peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease (2006) J. Neurosci. Res, 84, pp. 398-408
De Marchis, S., Modena, C., Peretto, P., Giffard, C., Fasolo, A., Carnosine-like immunoreactivity in the central nervous system of rats during postnatal development (2000) J. Comp. Neurol, 426, pp. 378-390
Calabrese, V., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem. Res, 30, pp. 797-807
Preston, J.E., Hipkiss, A.R., Himsworth, D.T., Romero, I.A., Abbott, J.N., Toxic effects of β-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and β-alanine (1998) Neurosci. Lett, 242, pp. 105-108
Hipkiss, A.R., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann. NY Acad. Sci, 854, pp. 37-53
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell. Mol. Life Sci, 59, pp. 546-551
Joshi, G., Glutathione elevation by ?-glutamylcysteine ethyl ester as a potential therapeutic strategy towards preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implications for chemobrain (2007) J. Neurosci. Res, 85, pp. 497-503
Tangpong, J., Adriamycin-induced, TNF-?-mediated central nervous system toxicity (2006) Neurobiol. Dis, 23, pp. 127-139
Silverman, D.H., Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy (2007) Breast Cancer Res. Treat, 103, pp. 303-311
Rahman, I., Biswas, S.K., Kirkham, P.A., Regulation of inflammation and redox signalling by dietary polyphenols (2006) Biochem. Pharmacol, 72, pp. 1439-1452
Sultana, R., Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: A regional study (2007) J. Cell. Mol. Med, 11, pp. 839-851
Butterfield, D. A. et al. Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiol. Dis. 22, 223-232 (2006). This was the first paper to describe proteomicsidentified oxidatively modified brain proteins in mild cognitive impairment, a precursor to Alzheimer's diseaseSalerno, L., Sorrenti, V., Di Giacomo, C., Romeo, G. & Siracusa, M. A. Progress in the development of selective nitric oxide synthase (NOS) inhibitors. Curr. Pharm. Des. 8, 177-200 (2002). This paper provides useful information about the selectivity of several NOS inhibitorsMejia-Garcia, T.A., Paes-de-Carvalho, R., Nitric oxide regulates cell survival in purified cultures of avian retinal neurons: Involvement of multiple transduction pathways (2007) J. Neurochem, 100, pp. 382-394
Privalle, C., Talarico, T., Keng, T., DeAngelo, J., Pyridoxalated hemoglobin polyoxyethylene: A nitric oxide scavenger with antioxidant activity for the treatment of nitric oxide-induced shock (2000) Free Radic. Biol. Med, 28, pp. 1507-1517
Kaur, H., Interaction of bilirubin and biliverdin with reactive nitrogen species (2003) FEBS Lett, 543, pp. 113-119
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.
At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
| ▼ Generation of innovative scaffolds by manipulating hyperstable proteins Design di scaffold innovativi mediante l’ingegnerizzazione di proteine termostabili |
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
Pepe G, Calce E, Verdoliva V, Saviano M, Maglione V, Di Pardo A, De Luca S
* Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders (38 visite)
Int J Mol Sci (ISSN: 1422-0067linking), 2020 Nov 23; 21(22): N/D-N/D.
Impact Factor: 4.556
Dettagli Esporta in BibTeX Esporta in EndNote
Cozzolino S, Balasco N, Vigorita M, Ruggiero A, Smaldone G, Del Vecchio P, Vitagliano L, Graziano G
* Guanidinium binding to proteins: The intriguing effects on the D1 and D2 domains of Thermotoga maritima Arginine Binding Protein and a comprehensive analysis of the Protein Data Bank (41 visite)
Int J Biol Macromol (ISSN: 0141-8130linking), 2020 Nov 15; 163: 375-385.
Impact Factor: 5.162
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Ruggiero A, Balasco N, Vitagliano L
* Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from Thermotoga maritima (49 visite)
Int J Mol Sci (ISSN: 1422-0067linking), 2020 Oct 12; 21(20): N/D-N/D.
Impact Factor: 4.556
Dettagli Esporta in BibTeX Esporta in EndNote
Famulari ES, Navarro-tableros V, Herrera Sanchez MB, Bortolussi G, Gai M, Conti L, Silengo L, Tolosano E, Tetta C, Muro AF, Camussi G, Fagoonee S, Altruda F
* Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice (134 visite)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2020 Jan 21; 10 (1 ): 887-887.
Impact Factor: 5.078
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Ruggiero A, Balasco N, Abuhammad A, Autiero I, Caruso D, Esposito D, Ferraro G, Gelardi E, L , M , Moreira M, Quareshy M, Romano M, Saaret A, Selvam I, Squeglia F, Troisi R, Kroon-batenburg L, M , J , Esposito L, Berisio R, Vitagliano L
* The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima (110 visite)
Acta Crystallogr F Struct Biol Commun, 2019 Nov; 75(Pt11): 707-713.
Impact Factor: 0.968
Dettagli Esporta in BibTeX Esporta in EndNote
Balasco N, Smaldone G, Vigorita M, Del Vecchio P, Graziano G, Ruggiero A, Vitagliano L
* The characterization of Thermotoga maritima Arginine Binding Protein variants demonstrates that minimal local strains have an important impact on protein stability (69 visite)
Sci Rep (ISSN: 2045-2322linking), 2019 Apr 29; 9(1): 6617-6617.
Impact Factor: 5.078
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Balasco N, Vigorita M, Ruggiero A, Cozzolino S, Berisio R, Del Vecchio P, Graziano G, Vitagliano L
* Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection (183 visite)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2018 Nov; 119: 758-769.
Impact Factor: 3.909
Dettagli Esporta in BibTeX Esporta in EndNote
Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (240 visite)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Berisio R, Balasco N, D'Auria S, Vitagliano L, Ruggiero A
* Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization (187 visite)
Bba-Gen Subjects (ISSN: 1570-9639print, 1570-9639linking, 0005-2728), 2018 May 31; 1866(9): 952-962.
Impact Factor: 2.773
Dettagli Esporta in BibTeX Esporta in EndNote
Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E
* Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna (72 visite)
Aquat Toxicol (ISSN: 0166-445xlinking), 2018 May; 198: 158-164.
Impact Factor:
Dettagli Esporta in BibTeX Esporta in EndNote
Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (360 visite) (PDF 172 visite)
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Bellia F, Arena G, Satriano C, Vecchio G, Rizzarelli E
* Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity (393 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jul 28; 135: 447-457.
Impact Factor: 4.816
Dettagli Esporta in BibTeX Esporta in EndNote
Altug C, Gunes H, Nocentini A, Monti SM, Buonanno M, Supuran CT
* Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties (257 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2017 Feb 15; 25(4): 1456-1464.
Impact Factor: 2.881
Dettagli Esporta in BibTeX Esporta in EndNote
Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
* Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon beta-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis (239 visite)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic, 1351-5101linking), 2017 Feb; 24(2): 446-449.
Impact Factor: 4.621
Dettagli Esporta in BibTeX Esporta in EndNote
Angapelly S, Ramya PVS, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M
* Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors (221 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2017; 25(2): 539-544.
Impact Factor: 2.881
Dettagli Esporta in BibTeX Esporta in EndNote
Troise AD, Buonanno M, Fiore A, Monti SM, Fogliano V
* Evolution of protein bound Maillard reaction end-products and free Amadori compounds in low lactose milk in presence of fructosamine oxidase (293 visite)
Food Chem (ISSN: 0308-8146, 0308-8146print), 2016 Dec 1; 212: 722-729.
Impact Factor: 4.529
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
* Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein (269 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Jul; 1864(7): 814-824.
Impact Factor: 4.932
Dettagli Esporta in BibTeX Esporta in EndNote
Sciuto S, Greco V, Rizzarelli E, Bellia F, Lanza V, Vaccaro S, Messina L
* Derivatives obtained from hyaluronic acid and carnosine (255 visite)
Google Patents, 2016 Feb 04; CA2951808A1: CA2951808-CA2951808.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (354 visite)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G
* Out of the active site binding pocket for carbonic anhydrase inhibitors (345 visite) (PDF 229 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2015 Jan 7; 51(2): 302-305.
Impact Factor: 6.567
Dettagli Esporta in BibTeX Esporta in EndNote
Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
* Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry (454 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015 Jan; 47(1): 111-124.
Impact Factor: 3.196
Dettagli Esporta in BibTeX Esporta in EndNote
Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A
* Recent developments of carbonic anhydrase inhibitors as potential drugs (381 visite)
Biomed Res Int (ISSN: 2314-6133, 2314-6141), 2015; 2015: 174178-174178.
Impact Factor: 2.134
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Rizzarelli E, Vecchio G
* The chemistry of carnosine derivatives (312 visite)
Food And Nutritional Components In Focus (ISSN: 2045-1695), 2015; 2015-January(8): 61-83.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Di Fiore A, Alterio V, Monti SM, De Simone G, D’Ambrosio K
* Thermostable carbonic anhydrases in biotechnological applications (412 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(7): 15456-15480.
Impact Factor: 3.257
Dettagli Esporta in BibTeX Esporta in EndNote
Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S
* Structural insights into and activity analysis of the antimicrobial peptide myxinidin (606 visite)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2014 Sep; 58(9): 5280-5290.
Impact Factor: 4.476
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
* A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima (360 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2014 May 15; 9(5): e96560-e96560.
Impact Factor: 3.234
Dettagli Esporta in BibTeX Esporta in EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (635 visite)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
Dettagli Esporta in BibTeX Esporta in EndNote
Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
* Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability (427 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1844(3): 632-640.
Impact Factor: 4.882
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Rizzarelli E
* Carnosinases, Their Substrates And Diseases (372 visite)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2014 Feb 21; 19(2): 2299-2329.
Impact Factor: 2.416
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (386 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (140 visite)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Villari V, Attanasio F, Micali N
* Control of the structural stability of α-crystallin under thermal and chemical stress: The role of carnosine (377 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207), 2014; 118(47): 13770-13776.
Impact Factor: 3.302
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Oliveri V, Rizzarelli E, Vecchio G
* New derivative of carnosine for nanoparticle assemblies (377 visite)
Eur J Med Chem (ISSN: 1768-3254, 0223-5234, 1768-3254electronic), 2013 Dec; 70: 225-232.
Impact Factor: 3.432
Dettagli Esporta in BibTeX Esporta in EndNote
Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (519 visite)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
Impact Factor: 4.451
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Alterio V, Supuran CT
* Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (382 visite)
Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
Impact Factor: 3.467
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (535 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
Dettagli Esporta in BibTeX Esporta in EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (389 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
Dettagli Esporta in BibTeX Esporta in EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (344 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Rizzarelli E
* Carnosine derivatives: new multifunctional drug-like molecules (394 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Jul; 43(1): 153-163.
Impact Factor: 3.914
Dettagli Esporta in BibTeX Esporta in EndNote
Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (338 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
Dettagli Esporta in BibTeX Esporta in EndNote
Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (531 visite)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (553 visite)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, Smaine F-Z, Carta F, De Simone G, Winum J-Y, Supuran CT
* Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups (410 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012; 55(15): 6776-6783.
Impact Factor: 5.614
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (382 visite)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
Dettagli Esporta in BibTeX Esporta in EndNote
Squeglia F, Marchetti R, Ruggiero A, Lanzetta R, Marasco D, Dworkin J, Petoukhov M, Molinaro A, Berisio R, Silipo A
* Chemical basis of peptidoglycan discrimination by PrkC, a key kinase involved in bacterial resuscitation from dormancy (342 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2011 Dec 28; 133(51): 20676-20679.
Impact Factor: 9.907
Dettagli Esporta in BibTeX Esporta in EndNote
Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (480 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D'Auria S, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein (335 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Nov 1; 67(11): 1462-1465.
Impact Factor: 0.506
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (396 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (585 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (352 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Bellia F, Arena G, Vecchio G, Rizzarelli E
* Noncovalent interaction-driven stereoselectivity of copper(II) complexes with cyclodextrin derivatives of L- and D-carnosine (1212 visite)
Inorg Chem (ISSN: 1520-510x, 0020-1669, 1520-510xelectronic), 2011 Jun 6; 50(11): 4917-4924.
Impact Factor: 4.601
Dettagli Esporta in BibTeX Esporta in EndNote
Panico M, Vallone G, Mollica C, Nicolai E, Di Cosmo N, Vajro P
* Massive hydrops of the gallbladder mimicking a choledochal cyst (246 visite)
J Pediatr Surg (ISSN: 0022-3468, 1531-5037electronic, 0022-3468linking), 2011 May; 46(5): 1015-1018.
Impact Factor: 1.45
Dettagli Esporta in BibTeX Esporta in EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (478 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (367 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
Dettagli Esporta in BibTeX Esporta in EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (332 visite)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
Dettagli Esporta in BibTeX Esporta in EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (375 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (407 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
Luchansky MS, Der BS, D'Auria S, Pocsfalvi G, Iozzino L, Marasco D, Dattelbaum JD
* Amino acid transport in thermophiles: characterization of an arginine-binding protein in Thermotoga maritima (402 visite)
Molecular Biosystems (ISSN: 1742-206x), 2010; 6(1): 142-151.
Impact Factor: 3.825
Dettagli Esporta in BibTeX Esporta in EndNote
D'Antò V, Michelotti A, Esposito L, Zagari A, Liguori R, Sacchetti L
* Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder (276 visite)
J Sci Med Sport (ISSN: 1440-2440), 2010; 13(6): 174-179.
Impact Factor: 3.194
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (394 visite)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (368 visite)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
Dettagli Esporta in BibTeX Esporta in EndNote
Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (436 visite)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Scozzafava A, Supuran CT
* Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (304 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321.
Impact Factor: 2.473
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (298 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (618 visite)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
Dettagli Esporta in BibTeX Esporta in EndNote
Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (347 visite)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (727 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
Dettagli Esporta in BibTeX Esporta in EndNote
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (384 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
Dettagli Esporta in BibTeX Esporta in EndNote
Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (635 visite)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone A, Vitagliano L, Berisio R
* Role of hydration in collagen triple helix stabilization (339 visite)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2008 Jul 18; 372(1): 121-125.
Impact Factor: 2.648
Dettagli Esporta in BibTeX Esporta in EndNote
Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
* Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (339 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
Impact Factor: 2.531
Dettagli Esporta in BibTeX Esporta in EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (386 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (359 visite)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (333 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Mar; 3(3): 473-477.
Impact Factor: 3.15
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (423 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
Dettagli Esporta in BibTeX Esporta in EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (573 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
Dettagli Esporta in BibTeX Esporta in EndNote
Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (336 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Impact Factor: 2.301
Dettagli Esporta in BibTeX Esporta in EndNote
Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (311 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
Dettagli Esporta in BibTeX Esporta in EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (372 visite)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
Dettagli Esporta in BibTeX Esporta in EndNote
Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
* Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (445 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2007 Mar 22; 50(6): 1241-1253.
Impact Factor: 4.895
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (221 visite)
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
Impact Factor: 1.713
Dettagli Esporta in BibTeX Esporta in EndNote
Chiechio S, Copani A, Gereau R, Nicoletti F
* Acetyl-l-carnitine in neuropathic pain (259 visite)
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
Impact Factor: 4.514
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Supuran CT
* Antiobesity carbonic anhydrase inhibitors (396 visite)
Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
Impact Factor: 4.325
Dettagli Esporta in BibTeX Esporta in EndNote
D'Auria S, Varriale A, Gonnelli M, Saviano M, Staiano M, Rossi M, Strambini GB
* Tryptophan phosphorescence studies of the D-galactose/ D-glucose-binding protein from Escherichia coli provide a molecular portrait with structural and dynamics features of the protein (519 visite)
J Proteome Res (ISSN: 1535-3893), 2007; 6(4): 1306-1312.
Impact Factor: 5.675
Dettagli Esporta in BibTeX Esporta in EndNote
Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (799 visite)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (412 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (610 visite)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
Dettagli Esporta in BibTeX Esporta in EndNote
Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (511 visite)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
Dettagli Esporta in BibTeX Esporta in EndNote
Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (443 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (305 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (306 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
Dettagli Esporta in BibTeX Esporta in EndNote
Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (436 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Apr 1; 15(7): 1937-1942.
Impact Factor: 2.478
Dettagli Esporta in BibTeX Esporta in EndNote
La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (459 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
Dettagli Esporta in BibTeX Esporta in EndNote
Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (302 visite)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
Dettagli Esporta in BibTeX Esporta in EndNote
Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (333 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
Dettagli Esporta in BibTeX Esporta in EndNote
Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (261 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Gouaux E
* High Resolution Crystallographic Studies Of Alpha-Hemolysin-Phospholipid Complexes Define Heptamer-Lipid Head Group Interactions: Implication For Understanding Protein-Lipid Interactions (292 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2004 Jun; 13(6): 1503-1511.
Impact Factor: 4.116
Dettagli Esporta in BibTeX Esporta in EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (351 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
Dettagli Esporta in BibTeX Esporta in EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (297 visite)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
Dettagli Esporta in BibTeX Esporta in EndNote
Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (430 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
Dettagli Esporta in BibTeX Esporta in EndNote
De Luca S, Ulhaq S, Dixon M J, EssexJ, Bradley M
* Solid-phase synthesis of a focused library of trypanothione reductase inhibitors (319 visite)
Tetrahedron Lett (ISSN: 0040-4039), 2003 Apr 7; 44(15): 3195-3197.
Impact Factor: 2.326
Dettagli Esporta in BibTeX Esporta in EndNote
Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (302 visite)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (366 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
Impact Factor: 2.908
Dettagli Esporta in BibTeX Esporta in EndNote
Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (447 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
Dettagli Esporta in BibTeX Esporta in EndNote
Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (287 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
Dettagli Esporta in BibTeX Esporta in EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Electrospray mass spectrometric studies of L-carnosine (β-alanyl-L-histidine) complexes with copper(II) or zinc ions in aqueous solution (342 visite)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic, 0951-4198linking), 2002; 16(7): 722-729.
Impact Factor: 2.372
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Sortino S, Rizzarelli E, Vecchiog
* Synthesis Of New Carnosine Derivatives Of R-Cyclodextrin And Their Hydroxyl Radical Scavanger Ability (289 visite)
Helvetica Chimica Acta, 2002; 85: 1633-1643.
Impact Factor: 1.394
Dettagli Esporta in BibTeX Esporta in EndNote
Vecchio G, La Mendola D, Rizzarelli E, Sortino S
* SOD-like activity of copper(II) complexes of beta-cyclodextrins functionalized with carnosine (256 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Sep; 86(1): N/D-N/D.
Impact Factor: 1.729
Dettagli Esporta in BibTeX Esporta in EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (271 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
Dettagli Esporta in BibTeX Esporta in EndNote
Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
The Crystal Structure Of Alpha-Thrombin-Hirunorm Iv Complex Reveals A Novel Specificity Site Recognition Mode (406 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1999 Jan; 8(1): 91-95.
Impact Factor: 4.457
Dettagli Esporta in BibTeX Esporta in EndNote
Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct (309 visite)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Impact Factor: 0.47
Dettagli Esporta in BibTeX Esporta in EndNote
Vai a fine pagina Versione per copia e incolla facile Esporta tutto in BibTeX Esporta tutto in EndNote
Pepe G, Calce E, Verdoliva V, Saviano M, Maglione V, Di Pardo A, De Luca S
* Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders (38 visite)
Int J Mol Sci (ISSN: 1422-0067linking), 2020 Nov 23; 21(22): N/D-N/D.
Impact Factor: 4.556
Dettagli Esporta in BibTeX Esporta in EndNote
Cozzolino S, Balasco N, Vigorita M, Ruggiero A, Smaldone G, Del Vecchio P, Vitagliano L, Graziano G
* Guanidinium binding to proteins: The intriguing effects on the D1 and D2 domains of Thermotoga maritima Arginine Binding Protein and a comprehensive analysis of the Protein Data Bank (41 visite)
Int J Biol Macromol (ISSN: 0141-8130linking), 2020 Nov 15; 163: 375-385.
Impact Factor: 5.162
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Ruggiero A, Balasco N, Vitagliano L
* Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from Thermotoga maritima (49 visite)
Int J Mol Sci (ISSN: 1422-0067linking), 2020 Oct 12; 21(20): N/D-N/D.
Impact Factor: 4.556
Dettagli Esporta in BibTeX Esporta in EndNote
Famulari ES, Navarro-tableros V, Herrera Sanchez MB, Bortolussi G, Gai M, Conti L, Silengo L, Tolosano E, Tetta C, Muro AF, Camussi G, Fagoonee S, Altruda F
* Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice (134 visite)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2020 Jan 21; 10 (1 ): 887-887.
Impact Factor: 5.078
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Ruggiero A, Balasco N, Abuhammad A, Autiero I, Caruso D, Esposito D, Ferraro G, Gelardi E, L , M , Moreira M, Quareshy M, Romano M, Saaret A, Selvam I, Squeglia F, Troisi R, Kroon-batenburg L, M , J , Esposito L, Berisio R, Vitagliano L
* The non-swapped monomeric structure of the arginine-binding protein from Thermotoga maritima (110 visite)
Acta Crystallogr F Struct Biol Commun, 2019 Nov; 75(Pt11): 707-713.
Impact Factor: 0.968
Dettagli Esporta in BibTeX Esporta in EndNote
Balasco N, Smaldone G, Vigorita M, Del Vecchio P, Graziano G, Ruggiero A, Vitagliano L
* The characterization of Thermotoga maritima Arginine Binding Protein variants demonstrates that minimal local strains have an important impact on protein stability (69 visite)
Sci Rep (ISSN: 2045-2322linking), 2019 Apr 29; 9(1): 6617-6617.
Impact Factor: 5.078
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Balasco N, Vigorita M, Ruggiero A, Cozzolino S, Berisio R, Del Vecchio P, Graziano G, Vitagliano L
* Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection (183 visite)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2018 Nov; 119: 758-769.
Impact Factor: 3.909
Dettagli Esporta in BibTeX Esporta in EndNote
Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (240 visite)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Berisio R, Balasco N, D'Auria S, Vitagliano L, Ruggiero A
* Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization (187 visite)
Bba-Gen Subjects (ISSN: 1570-9639print, 1570-9639linking, 0005-2728), 2018 May 31; 1866(9): 952-962.
Impact Factor: 2.773
Dettagli Esporta in BibTeX Esporta in EndNote
Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E
* Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna (72 visite)
Aquat Toxicol (ISSN: 0166-445xlinking), 2018 May; 198: 158-164.
Impact Factor:
Dettagli Esporta in BibTeX Esporta in EndNote
Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (360 visite) (PDF 172 visite)
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Bellia F, Arena G, Satriano C, Vecchio G, Rizzarelli E
* Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity (393 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jul 28; 135: 447-457.
Impact Factor: 4.816
Dettagli Esporta in BibTeX Esporta in EndNote
Altug C, Gunes H, Nocentini A, Monti SM, Buonanno M, Supuran CT
* Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties (257 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2017 Feb 15; 25(4): 1456-1464.
Impact Factor: 2.881
Dettagli Esporta in BibTeX Esporta in EndNote
Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
* Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon beta-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis (239 visite)
Eur J Neurol (ISSN: 1351-5101, 1468-1331electronic, 1351-5101linking), 2017 Feb; 24(2): 446-449.
Impact Factor: 4.621
Dettagli Esporta in BibTeX Esporta in EndNote
Angapelly S, Ramya PVS, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M
* Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors (221 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391), 2017; 25(2): 539-544.
Impact Factor: 2.881
Dettagli Esporta in BibTeX Esporta in EndNote
Troise AD, Buonanno M, Fiore A, Monti SM, Fogliano V
* Evolution of protein bound Maillard reaction end-products and free Amadori compounds in low lactose milk in presence of fructosamine oxidase (293 visite)
Food Chem (ISSN: 0308-8146, 0308-8146print), 2016 Dec 1; 212: 722-729.
Impact Factor: 4.529
Dettagli Esporta in BibTeX Esporta in EndNote
Smaldone G, Vigorita M, Ruggiero A, Balasco N, Dattelbaum JD, D'Auria S, Del Vecchio P, Graziano G, Vitagliano L
* Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein (269 visite)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Jul; 1864(7): 814-824.
Impact Factor: 4.932
Dettagli Esporta in BibTeX Esporta in EndNote
Sciuto S, Greco V, Rizzarelli E, Bellia F, Lanza V, Vaccaro S, Messina L
* Derivatives obtained from hyaluronic acid and carnosine (255 visite)
Google Patents, 2016 Feb 04; CA2951808A1: CA2951808-CA2951808.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Vicidomini C, Di Gaetano S, Capasso D, Musumeci D, Roviello V
* Solid phase synthesis and RNA-binding activity of an arginine-containing nucleopeptide (354 visite)
Rsc Adv (ISSN: 2046-2069), 2016; 6(17): 14140-14148.
Impact Factor: 3.108
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G
* Out of the active site binding pocket for carbonic anhydrase inhibitors (345 visite) (PDF 229 visite)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2015 Jan 7; 51(2): 302-305.
Impact Factor: 6.567
Dettagli Esporta in BibTeX Esporta in EndNote
Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
* Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry (454 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015 Jan; 47(1): 111-124.
Impact Factor: 3.196
Dettagli Esporta in BibTeX Esporta in EndNote
Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A
* Recent developments of carbonic anhydrase inhibitors as potential drugs (381 visite)
Biomed Res Int (ISSN: 2314-6133, 2314-6141), 2015; 2015: 174178-174178.
Impact Factor: 2.134
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Rizzarelli E, Vecchio G
* The chemistry of carnosine derivatives (312 visite)
Food And Nutritional Components In Focus (ISSN: 2045-1695), 2015; 2015-January(8): 61-83.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Di Fiore A, Alterio V, Monti SM, De Simone G, D’Ambrosio K
* Thermostable carbonic anhydrases in biotechnological applications (412 visite)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(7): 15456-15480.
Impact Factor: 3.257
Dettagli Esporta in BibTeX Esporta in EndNote
Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S
* Structural insights into and activity analysis of the antimicrobial peptide myxinidin (606 visite)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2014 Sep; 58(9): 5280-5290.
Impact Factor: 4.476
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
* A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima (360 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2014 May 15; 9(5): e96560-e96560.
Impact Factor: 3.234
Dettagli Esporta in BibTeX Esporta in EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (635 visite)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
Dettagli Esporta in BibTeX Esporta in EndNote
Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
* Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability (427 visite)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1844(3): 632-640.
Impact Factor: 4.882
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Rizzarelli E
* Carnosinases, Their Substrates And Diseases (372 visite)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2014 Feb 21; 19(2): 2299-2329.
Impact Factor: 2.416
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (386 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (140 visite)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
Villari V, Attanasio F, Micali N
* Control of the structural stability of α-crystallin under thermal and chemical stress: The role of carnosine (377 visite)
J Phys Chem B (ISSN: 1520-6106, 1520-5207), 2014; 118(47): 13770-13776.
Impact Factor: 3.302
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Oliveri V, Rizzarelli E, Vecchio G
* New derivative of carnosine for nanoparticle assemblies (377 visite)
Eur J Med Chem (ISSN: 1768-3254, 0223-5234, 1768-3254electronic), 2013 Dec; 70: 225-232.
Impact Factor: 3.432
Dettagli Esporta in BibTeX Esporta in EndNote
Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (519 visite)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
Impact Factor: 4.451
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Alterio V, Supuran CT
* Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (382 visite)
Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
Impact Factor: 3.467
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (535 visite)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
Dettagli Esporta in BibTeX Esporta in EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (389 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
Dettagli Esporta in BibTeX Esporta in EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (344 visite)
Curr Protein Pept Sci (ISSN: 1389-2037), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Rizzarelli E
* Carnosine derivatives: new multifunctional drug-like molecules (394 visite)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Jul; 43(1): 153-163.
Impact Factor: 3.914
Dettagli Esporta in BibTeX Esporta in EndNote
Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (338 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
Dettagli Esporta in BibTeX Esporta in EndNote
Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (531 visite)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (553 visite)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, Smaine F-Z, Carta F, De Simone G, Winum J-Y, Supuran CT
* Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups (410 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012; 55(15): 6776-6783.
Impact Factor: 5.614
Dettagli Esporta in BibTeX Esporta in EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (382 visite)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
Dettagli Esporta in BibTeX Esporta in EndNote
Squeglia F, Marchetti R, Ruggiero A, Lanzetta R, Marasco D, Dworkin J, Petoukhov M, Molinaro A, Berisio R, Silipo A
* Chemical basis of peptidoglycan discrimination by PrkC, a key kinase involved in bacterial resuscitation from dormancy (342 visite)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2011 Dec 28; 133(51): 20676-20679.
Impact Factor: 9.907
Dettagli Esporta in BibTeX Esporta in EndNote
Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (480 visite)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
Dettagli Esporta in BibTeX Esporta in EndNote
Ruggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D'Auria S, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein (335 visite)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Nov 1; 67(11): 1462-1465.
Impact Factor: 0.506
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (396 visite)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (585 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (352 visite)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
Dettagli Esporta in BibTeX Esporta in EndNote
Grasso GI, Bellia F, Arena G, Vecchio G, Rizzarelli E
* Noncovalent interaction-driven stereoselectivity of copper(II) complexes with cyclodextrin derivatives of L- and D-carnosine (1212 visite)
Inorg Chem (ISSN: 1520-510x, 0020-1669, 1520-510xelectronic), 2011 Jun 6; 50(11): 4917-4924.
Impact Factor: 4.601
Dettagli Esporta in BibTeX Esporta in EndNote
Panico M, Vallone G, Mollica C, Nicolai E, Di Cosmo N, Vajro P
* Massive hydrops of the gallbladder mimicking a choledochal cyst (246 visite)
J Pediatr Surg (ISSN: 0022-3468, 1531-5037electronic, 0022-3468linking), 2011 May; 46(5): 1015-1018.
Impact Factor: 1.45
Dettagli Esporta in BibTeX Esporta in EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (478 visite)
Plosone (ISSN: 1932-6203, 1932-6203electronic), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
Dettagli Esporta in BibTeX Esporta in EndNote
Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (367 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
Dettagli Esporta in BibTeX Esporta in EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (332 visite)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
Dettagli Esporta in BibTeX Esporta in EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (375 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
Dettagli Esporta in BibTeX Esporta in EndNote
Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (407 visite)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
Dettagli Esporta in BibTeX Esporta in EndNote
Luchansky MS, Der BS, D'Auria S, Pocsfalvi G, Iozzino L, Marasco D, Dattelbaum JD
* Amino acid transport in thermophiles: characterization of an arginine-binding protein in Thermotoga maritima (402 visite)
Molecular Biosystems (ISSN: 1742-206x), 2010; 6(1): 142-151.
Impact Factor: 3.825
Dettagli Esporta in BibTeX Esporta in EndNote
D'Antò V, Michelotti A, Esposito L, Zagari A, Liguori R, Sacchetti L
* Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder (276 visite)
J Sci Med Sport (ISSN: 1440-2440), 2010; 13(6): 174-179.
Impact Factor: 3.194
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (394 visite)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, Limauro D, Pedone E, Galdi I, Pedone C, Bartolucci S, De Simone G
* Insights into the catalytic mechanism of the Bcp family: functional and structural analysis of Bcp1 from Sulfolobus solfataricus (368 visite)
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic), 2009 Sep; 76(4): 995-1006.
Impact Factor: 3.085
Dettagli Esporta in BibTeX Esporta in EndNote
Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (436 visite)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Scozzafava A, Supuran CT
* Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (304 visite)
Chem Biol Drug Des Chemical Biology And Drug Design (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321.
Impact Factor: 2.473
Dettagli Esporta in BibTeX Esporta in EndNote
Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (298 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (618 visite)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
Dettagli Esporta in BibTeX Esporta in EndNote
Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (347 visite)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (727 visite)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
Dettagli Esporta in BibTeX Esporta in EndNote
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (384 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
Dettagli Esporta in BibTeX Esporta in EndNote
Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (635 visite)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone A, Vitagliano L, Berisio R
* Role of hydration in collagen triple helix stabilization (339 visite)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2008 Jul 18; 372(1): 121-125.
Impact Factor: 2.648
Dettagli Esporta in BibTeX Esporta in EndNote
Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
* Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (339 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
Impact Factor: 2.531
Dettagli Esporta in BibTeX Esporta in EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (386 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (359 visite)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
Dettagli Esporta in BibTeX Esporta in EndNote
D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (333 visite)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Mar; 3(3): 473-477.
Impact Factor: 3.15
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (423 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
Dettagli Esporta in BibTeX Esporta in EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (573 visite)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
Dettagli Esporta in BibTeX Esporta in EndNote
Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (336 visite)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Impact Factor: 2.301
Dettagli Esporta in BibTeX Esporta in EndNote
Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (311 visite)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
Dettagli Esporta in BibTeX Esporta in EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (372 visite)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
Dettagli Esporta in BibTeX Esporta in EndNote
Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G
* Small molecule inhibitors of histone arginine methyltransferases: Homology modeling, molecular docking, binding mode analysis, and biological evaluations (445 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2007 Mar 22; 50(6): 1241-1253.
Impact Factor: 4.895
Dettagli Esporta in BibTeX Esporta in EndNote
Bellia F, La Mendola D, Maccarrone G, Mineo P, Vitalini D, Scamporrino E, Sortino S, Vecchio G, Rizzarelli E
* Copper(II) Complexes With Beta-Cyclodextrin-Homocarnosine Conjugates And Their Antioxidant Activity (221 visite)
Inorg Chim Acta (ISSN: 0020-1693), 2007 Feb 15; 360(3): 945-954.
Impact Factor: 1.713
Dettagli Esporta in BibTeX Esporta in EndNote
Chiechio S, Copani A, Gereau R, Nicoletti F
* Acetyl-l-carnitine in neuropathic pain (259 visite)
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
Impact Factor: 4.514
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Supuran CT
* Antiobesity carbonic anhydrase inhibitors (396 visite)
Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
Impact Factor: 4.325
Dettagli Esporta in BibTeX Esporta in EndNote
D'Auria S, Varriale A, Gonnelli M, Saviano M, Staiano M, Rossi M, Strambini GB
* Tryptophan phosphorescence studies of the D-galactose/ D-glucose-binding protein from Escherichia coli provide a molecular portrait with structural and dynamics features of the protein (519 visite)
J Proteome Res (ISSN: 1535-3893), 2007; 6(4): 1306-1312.
Impact Factor: 5.675
Dettagli Esporta in BibTeX Esporta in EndNote
Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (799 visite)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P
* Small-molecule inhibitors of histone acetyltransferase activity: Identification and biological properties (412 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 16; 49(23): 6897-6907.
Impact Factor: 5.115
Dettagli Esporta in BibTeX Esporta in EndNote
D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (610 visite)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
Dettagli Esporta in BibTeX Esporta in EndNote
Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (511 visite)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
Dettagli Esporta in BibTeX Esporta in EndNote
Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (443 visite)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
Dettagli Esporta in BibTeX Esporta in EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (305 visite)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
Dettagli Esporta in BibTeX Esporta in EndNote
De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (306 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
Dettagli Esporta in BibTeX Esporta in EndNote
Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (436 visite)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Apr 1; 15(7): 1937-1942.
Impact Factor: 2.478
Dettagli Esporta in BibTeX Esporta in EndNote
La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (459 visite)
Arch Biochem Biophys (ISSN: 0003-9861), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
Dettagli Esporta in BibTeX Esporta in EndNote
Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (302 visite)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
Dettagli Esporta in BibTeX Esporta in EndNote
Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (333 visite)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
Dettagli Esporta in BibTeX Esporta in EndNote
Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (261 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
Dettagli Esporta in BibTeX Esporta in EndNote
Galdiero S, Gouaux E
* High Resolution Crystallographic Studies Of Alpha-Hemolysin-Phospholipid Complexes Define Heptamer-Lipid Head Group Interactions: Implication For Understanding Protein-Lipid Interactions (292 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2004 Jun; 13(6): 1503-1511.
Impact Factor: 4.116
Dettagli Esporta in BibTeX Esporta in EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (351 visite)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
Dettagli Esporta in BibTeX Esporta in EndNote
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (297 visite)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
Dettagli Esporta in BibTeX Esporta in EndNote
Vitagliano L, Ruggiero A, Masullo M, Cantiello P, Arcari P, Zagari A
* The Crystal Structure Of Sulfolobus Solfataricus Elongation Factor 1 Alpha In Complex With Magnesium And Gdp (430 visite)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2004; 43(21): 6630-6636.
Impact Factor: 4.008
Dettagli Esporta in BibTeX Esporta in EndNote
De Luca S, Ulhaq S, Dixon M J, EssexJ, Bradley M
* Solid-phase synthesis of a focused library of trypanothione reductase inhibitors (319 visite)
Tetrahedron Lett (ISSN: 0040-4039), 2003 Apr 7; 44(15): 3195-3197.
Impact Factor: 2.326
Dettagli Esporta in BibTeX Esporta in EndNote
Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (302 visite)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
Dettagli Esporta in BibTeX Esporta in EndNote
Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (366 visite)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
Impact Factor: 2.908
Dettagli Esporta in BibTeX Esporta in EndNote
Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (447 visite)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
Dettagli Esporta in BibTeX Esporta in EndNote
Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (287 visite)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
Dettagli Esporta in BibTeX Esporta in EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Electrospray mass spectrometric studies of L-carnosine (β-alanyl-L-histidine) complexes with copper(II) or zinc ions in aqueous solution (342 visite)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic, 0951-4198linking), 2002; 16(7): 722-729.
Impact Factor: 2.372
Dettagli Esporta in BibTeX Esporta in EndNote
La Mendola D, Sortino S, Rizzarelli E, Vecchiog
* Synthesis Of New Carnosine Derivatives Of R-Cyclodextrin And Their Hydroxyl Radical Scavanger Ability (289 visite)
Helvetica Chimica Acta, 2002; 85: 1633-1643.
Impact Factor: 1.394
Dettagli Esporta in BibTeX Esporta in EndNote
Vecchio G, La Mendola D, Rizzarelli E, Sortino S
* SOD-like activity of copper(II) complexes of beta-cyclodextrins functionalized with carnosine (256 visite)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Sep; 86(1): N/D-N/D.
Impact Factor: 1.729
Dettagli Esporta in BibTeX Esporta in EndNote
Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (271 visite)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
Dettagli Esporta in BibTeX Esporta in EndNote
Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
The Crystal Structure Of Alpha-Thrombin-Hirunorm Iv Complex Reveals A Novel Specificity Site Recognition Mode (406 visite)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1999 Jan; 8(1): 91-95.
Impact Factor: 4.457
Dettagli Esporta in BibTeX Esporta in EndNote
Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct (309 visite)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Impact Factor: 0.47
Dettagli Esporta in BibTeX Esporta in EndNote
111 Records (106 escludendo Abstract e Conferenze).
Impact factor totale: 430.43 (410.766 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 429.433 (407.372 escludendo Abstract e Conferenze).
Impact factor totale: 430.43 (410.766 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 429.433 (407.372 escludendo Abstract e Conferenze).
Last modified by Ultima modifica di Marco Comerci on in data Sunday 12 July 2020, 13:15:04
494 views visite. Last view on Ultima visita in data Monday 10 May 2021, 15:22:43
ibb.cnr.it