Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (628 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Comparative Study, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Review,
Impact factor: 24.52, 5-year impact factor: 26.723
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34648836983&partnerID=40&md5=2445a8b7daad027f5269ca9b66d38e90
Keywords: Acetylcarnitine, Amide, Arginine, Arginine Derivative, Bilirubin, Carbonate Dehydratase Ii, Carnosine, Curcumin, Cyclic Amp Responsive Element Binding Protein, Cyclic Gmp Derivative, Doxorubicin, Endothelial Nitric Oxide Synthase, Ferulic Acid, Heat Shock Protein, Heme Oxygenase, Hemoglobin, Hemoglobin Derivative, Imidazoline Derivative, Inducible Nitric Oxide Synthase, N(g) Nitroarginine Methyl Ester, Neuronal Nitric Oxide Synthase, Nitric Oxide Donor, Nitro Derivative, Ornithine Derivative, Protein Kinase B, Quinoxaline Derivative, Sildenafil, Thiol Derivative, Tumor Necrosis Factor, Alzheimer Disease, Antiinflammatory Activity, Antioxidant Activity, Brain Ischemia, Brain Region, Cell Survival, Central Nervous System, Chronic Fatigue Syndrome, Cognition, Cognitive Defect, Concentration (parameters), Dementia, Depression, Diabetic Neuropathy, Enzyme Localization, Fluid Balance, Human, Human Immunodeficiency Virus Infection, Huntington Chorea, Impotence, Multiple Sclerosis, Nerve Cell Necrosis, Nerve Cell Plasticity, Neuromodulation, Neuroprotection, Neurotoxicity, Neurotransmission, Nitrosative Stress, Nitrosylation, Nonhuman, Oxidation Reduction Reaction, Priority Journal, Protein Expression, Protein Family, Protein Secretion, Proteomics, Pulmonary Hypertension, Reperfusion Injury, Reproduction, Review, Signal Transduction, Sleep Waking Cycle, Somnolence, Animals, Neurodegenerative Diseases, Neuroprotective Agents, Neurotoxicity Syndromes, N (g) Nitroarginine Methyl Ester,
Affiliations:
*** IBB - CNR ***
Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. calabres@unict.it
Institute of Pharmacology, Catholic University School of Medicine, Roma, Italy
Department of Internal Medicine, Catholic University School of Medicine, Roma, Italy
References:
Guix, F. X., Uribesalgo, I., Coma, M. & Munoz, F. J. The physiology and pathophysiology of nitric oxide in the brain. Prog. Neurobiol. 76, 126-152 (2005). A comprehensive review of NO functions in the brainRivier, C. Role of gaseous neurotransmitters in the hypothalamic- pituitary-adrenal axis. Ann. NY Acad. Sci. 933, 254-264 (2001). A useful paper for understanding the controversial action of NO in the regulation of the stress axisMcCann, S.M., The nitric oxide hypothesis of brain aging (1997) Exp. Gerontol, 32, pp. 431-44
Toda, N., Ayajiki, K., Okamura, T., Nitric oxide and penile erectile function (2005) Pharmacol. Ther, 106, pp. 233-266
Takahashi, T., Pathophysiological significance of neuronal nitric oxide synthase in the gastrointestinal tract (2003) J. Gastroenterol, 38, pp. 421-430
Currò, D., Preziosi, P., Non-adrenergic noncholinergic relaxation of the rat stomach (1998) Gen. Pharmacol, 31, pp. 697-703
Pacher, P., Beckman, J.S., Liaudet, L., Nitric oxide and peroxynitrite in health and disease (2007) Physiol. Rev, 87, pp. 315-424
Hirst, D.G., Robson, T., Nitrosative stress in cancer therapy (2007) Front. Biosci, 12, pp. 3406-3418
Ridnour, L.A., The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations (2004) Biol. Chem, 385, pp. 1-10
Sultana, R., Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach (2006) Neurobiol. Dis, 22, pp. 76-87
Castegna A. et al. Proteomic identification of nitrated proteins in Alzheimer's disease brain. J. Neurochem. 85, 1394-1401 (2003). This was the first proteomics study to identify nitrated proteins in the brain of patients with Alzheimer's diseaseBredt, D.S., Endogenous nitric oxide synthesis: Biological functions and pathophysiology (1999) Free Radic. Res, 31, pp. 577-596
Dawson, T. M. & Snyder, S. H. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J. Neurosci. 14, 5147-5159 (1994). This paper provides details on the distribution of nNOS in the CNS and PNSRodrigo, J., Localization of nitric oxide synthase in the adult rat brain (1994) Philos. Trans. R. Soc. Lond. B Biol. Sci, 345, pp. 175-221
Vincent, S.R., Kimura, H., Histochemical mapping of nitric oxide synthase in the rat brain (1992) Neuroscience, 46, pp. 755-784
Bredt, D.S., Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase (1991) Neuron, 7, pp. 615-624
De Giorgio, R., Nitric oxide producing neurons in the monkey and human digestive system (1994) J. Comp. Neurol, 342, pp. 619-627
Magee, T., Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract (1996) Biochem. Biophys. Res. Commun, 226, pp. 145-151
Calabrese, V., Butterfield, D.A., Scapagnini, G., Stella, A.M., Maines, M.D., Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: Relevance to brain aging, neurodegenerative disorders, and longevity (2006) Antioxid. Redox Signal, 8, pp. 444-477
Colasanti, M., Expression of a NOS-III-like protein in human astroglial cell culture (1998) Biochem. Biophys. Res. Commun, 252, pp. 552-555
Rajasekaran, M., Ex vivo expression of nitric oxide synthase isoforms (eNOS/iNOS) and calmodulin in human penile cavernosal cells (1998) J. Urol, 160, pp. 2210-2215
Arnold, W. P., Mittal, C. K., Katsuki, S. & Murad, F. Nitric oxide activates guanylate cyclase and increases guanosine 3?-5?-cyclic monophosphate levels in various tissue preparations. Proc. Natl Acad. Sci. USA 74, 3203-3207 (1977). A milestone paper about the ability of NO to activate sGCKrumenacker, J.S., Hanafy, K.A., Murad, F., Regulation of nitric oxide and soluble guanylyl cyclase (2004) Brain Res. Bull, 62, pp. 505-515
Nakane, M., Soluble guanylyl cyclase: Physiological role as an NO receptor and the potential molecular target for therapeutic application (2003) Clin. Chem. Lab. Med, 41, pp. 865-870
Uretsky, A.D., Weiss, B.L., Yunker, W.K., Chang, J.P., Nitric oxide produced by a novel nitric oxide synthase isoform is necessary for gonadotropin-releasing hormone-induced growth hormone secretion via a cGMP-dependent mechanism (2003) J. Neuroendocrinol, 15, pp. 667-676
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., Salvemini, D., Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors (2005) Pharmacol. Rev, 57, pp. 217-252
Motterlini, R., Green, C.J., Foresti, R., Regulation of heme oxygenase-1 by redox signals involving nitric oxide (2002) Antioxid. Redox Signal, 4, pp. 615-624
Contestabile, A., Ciani, E., Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation (2004) Neurochem. Int, 45, pp. 903-914
Riccio, A. et al. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol. Cell 21, 283-294 (2006). This study demonstrates that the NO pathway controls CREB-DNA binding and CRE-mediated gene expressionFoster, M.W., McMahon, T.J., Stamler, J.S., S-nitrosylation in health and disease (2003) Trends Mol. Med, 9, pp. 160-168
Garthwaite, J., Charles, S. L. & Chess-Williams, R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336, 385-388 (1988). A landmark paper that demonstrates that EDRF, the early name given to NO, is involved in neurotransmissionPalmer, R.M., Ferrige, A.G., Moncada, S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor (1987) Nature, 327, pp. 524-526
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E. & Chaudhuri, G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl Acad. Sci. USA 84, 9265-9269 (1987). A milestone paper that reveals the identity of EDRF as NOGarthwaite, J., Boulton, C.L., Nitric oxide signaling in the central nervous system (1995) Annu. Rev. Physiol, 57, pp. 683-706
Sanders, K.M., Ward, S.M., Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission (1992) Am. J. Physiol, 262, pp. G379-G392
Prast, H., Tran, M.H., Fischer, H., Philippu, A., Nitric oxide-induced release of acetylcholine in the nucleus accumbens: Role of cyclic GMP, glutamate, and GABA (1998) J. Neurochem, 71, pp. 266-273
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S., Whitton, P.S., Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo (1996) Brain Res, 717, pp. 196-199
Ohkuma, S., Katsura, M., Chen, D.Z., Narihara, H., Kuriyama, K., Nitric oxide-evoked [3H]γ-aminobutyric acid release is mediated by two distinct release mechanisms (1996) Brain Res. Mol. Brain Res, 36, pp. 137-144
Lonart, G., Wang, J., Johnson, K.M., Nitric oxide induces neurotransmitter release from hippocampal slices (1992) Eur. J. Pharmacol, 220, pp. 271-272
Lorrain, D.S., Hull, E.M., Nitric oxide increases dopamine and serotonin release in the medial preoptic area (1993) Neuroreport, 5, pp. 87-89
Kaehler, S.T., Singewald, N., Sinner, C., Philippu, A., Nitric oxide modulates the release of serotonin in the rat hypothalamus (1999) Brain Res, 835, pp. 346-349
Bon, C.L., Garthwaite, J., On the role of nitric oxide in hippocampal long-term potentiation (2003) J. Neurosci, 23, pp. 1941-1948
Boulton, C.L., Southam, E., Garthwaite, J., Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase (1995) Neuroscience, 69, pp. 699-703
Chien, W.L., Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1- benzylindazole (2003) Mol. Pharmacol, 63, pp. 1322-1328
Hars, B., Endogenous nitric oxide in the rat pons promotes sleep (1999) Brain Res, 816, pp. 209-219
Datta, S., Patterson, E.H., Siwek, D.F., Endogenous and exogenous nitric oxide in the pedunculopontine tegmentum induces sleep (1997) Synapse, 27, pp. 69-78
Cavas, M., Navarro, J.F., Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat (2006) Prog. Neuropsychopharmacol. Biol. Psychiatry, 30, pp. 56-67
Stern, J.E., Nitric oxide and homeostatic control: An intercellular signalling molecule contributing to autonomic and neuroendocrine integration? (2004) Prog. Biophys. Mol. Biol, 84, pp. 197-215
Toni, R., Malaguti, A., Benfenati, F., Martini, L., The human hypothalamus: A morpho-functional perspective (2004) J. Endocrinol. Invest, 27, pp. 73-94
Tsigos, C., Chrousos, G.P., Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress (2002) J. Psychosom. Res, 53, pp. 865-871
Barberis, C., Tribollet, E., Vasopressin and oxytocin receptors in the central nervous system (1996) Crit. Rev. Neurobiol, 10, pp. 119-154
Tringali, G., Aubry, J.M., Navarra, P., Pozzoli, G., Lamotrigine inhibits basal and Na+-stimulated, but not Ca2+-stimulated, release of corticotropin-releasing hormone from the rat hypothalamus (2006) Psychopharmacology (Berl.), 188, pp. 386-392
Costa, A., Trainer, P., Besser, M., Grossman, A., Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro (1993) Brain Res, 605, pp. 187-192
Yasin, S., Nitric oxide modulates the release of vasopressin from rat hypothalamic explants (1993) Endocrinology, 133, pp. 1466-1469
Nguyen, K.T., Exposure to acute stress induces brain interleukin-1β protein in the rat (1998) J. Neurosci, 18, pp. 2239-2246
Karanth, S., Lyson, K., McCann, S.M., Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami (1993) Proc. Natl Acad. Sci. USA, 90, pp. 3383-3387
Rivier, C., Role of nitric oxide in regulating the rat hypothalamic-pituitary-adrenal axis response to endotoxemia (2003) Ann. NY Acad. Sci, 992, pp. 72-85
Kadekaro, M., Nitric oxide modulation of the hypothalamo-neurohypophyseal system (2004) Braz. J. Med. Biol. Res, 37, pp. 441-450
Brann, D.W., Bhat, G.K., Lamar, C.A., Mahesh, V.B., Gaseous transmitters and neuroendocrine regulation (1997) Neuroendocrinology, 65, pp. 385-395
Argiolas, A., Melis, M.R., Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus (2005) Prog. Neurobiol, 76, pp. 1-21
Mancuso, C., Heme oxygenase and its products in the nervous system (2004) Antioxid. Redox Signal, 6, pp. 878-887
Mancuso, C., Inhibition of heme oxygenase in the central nervous system potentiates endotoxin-induced vasopressin release in the rat (1999) J. Neuroimmunol, 99, pp. 189-194
Mancuso, C. et al. Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function. Brain Res. Mol. Brain Res. 50, 267-276 (1997). This was the first paper to provide direct evidence that carbon monoxide is involved in the regulation of vasopressin release from rat hypothalamic explantsPozzoli, G., Carbon monoxide as a novel neuroendocrine modulator: Inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants (1994) Endocrinology, 135, pp. 2314-2317
Jaffrey, S.R., Erdjument-Bromage, H., Ferris, C.D., Tempst, P., Snyder, S.H., Protein S-nitrosylation: A physiological signal for neuronal nitric oxide (2001) Nature Cell Biol, 3, pp. 193-197
Choi, Y.B., Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation (2000) Nature Neurosci, 3, pp. 15-21
Lipton, S.A., Singel, D.J., Stamler, J.S., Nitric oxide in the central nervous system (1994) Prog. Brain Res, 103, pp. 359-364
Mungrue, I.N., Bredt, D.S., nNOS at a glance: Implications for brain and brawn (2004) Cell Sci, 117, pp. 2627-2629
Melino, G., S-nitrosylation regulates apoptosis (1997) Nature, 388, pp. 432-433
Liu, L. & Stamler, J. S. NO: an inhibitor of cell death. Cell Death Differ. 6, 937-942 (1999)Mannick, J.B., S-Nitrosylation of mitochondrial caspases (2001) J. Cell Biol, 154, pp. 1111-1116
Tenneti, L., D'Emilia, D.M., Lipton, S.A., Suppression of neuronal apoptosis by S-nitrosylation of caspases (1997) Neurosci. Lett, 236, pp. 139-142
Zhou, P., Qian, L., Iadecola, C., Nitric oxide inhibits caspase activation and apoptotic morphology but does not rescue neuronal death (2005) J. Cereb. Blood Flow Metab, 25, pp. 348-357
Kitamura, Y., In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: Possible involvement of nitric oxide production from inducible nitric oxide synthase (1998) Glia, 22, pp. 138-148
Mancuso, C., Bonsignore, A., Di Stasio, E., Mordente, A. & Motterlini, R. Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide. Biochem. Pharmacol. 66, 2355-2363 (2003). In this paper, the authors describe the ability of bilirubin to interact with S-nitrosothiolsGood, P.F., Hsu, A., Werner, P., Perl, D.P., Olanow, C.W., Protein nitration in Parkinson's disease (1998) J. Neuropathol. Exp. Neurol, 57, pp. 338-342
Mancuso, C., Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders (2007) Front. Biosci, 12, pp. 1107-1123
Dalle-Donne, I., Scaloni, A. & Butterfield, D. A. (Eds) Redox Proteomics: From Protein Modifications to Cellular Dysfunctions and Diseases (John Wiley & Sons, New Jersey, 2006). A comprehensive treatise on the identification of oxidatively modified proteins in health and diseaseCastegna, A., Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: Dihydropyrimidinase- related protein 2, α-enolase and heat shock cognate 71 (2002) J. Neurochem, 82, pp. 1524-1532
Messier, C., Gagnon, M., Glucose regulation and brain aging (2000) J. Nutr. Health Aging, 4, pp. 208-213
Vanhanen, M., Soininen, H., Glucose intolerance, cognitive impairment and Alzheimer's disease (1998) Curr. Opin. Neurol, 11, pp. 673-677
Ojika, K., Tsugu, Y., Mitake, S., Otsuka, Y., Katada, E., NMDA receptor activation enhances the release of a cholinergic differentiation peptide (HCNP) from hippocampal neurons in vitro (1998) Brain Res. Dev. Brain Res, 106, pp. 173-180
Rossor, M.N., The substantia innominata in Alzheimer's disease: An histochemical and biochemical study of cholinergic marker enzymes (1982) Neurosci. Lett, 28, pp. 217-222
Giacobini, E., Cholinergic function and Alzheimer's disease (2003) Int. J. Geriatr. Psychiatry, 18, pp. S1-S5
Sun, M.K., Alkon, D.L., Carbonic anhydrase gating of attention: Memory therapy and enhancement (2002) Trends Pharmacol. Sci, 23, pp. 83-89
Chuang, D.M., Hough, C., Senatorov, V.V., Glyceraldehyde-3- phosphate dehydrogenase, apoptosis, and neurodegenerative diseases (2005) Annu. Rev. Pharmacol. Toxicol, 45, pp. 269-290
Browne, S.E., Beal, M.F., Oxidative damage in Huntington's disease pathogenesis (2006) Antioxid. Redox Signal, 8, pp. 2061-2073
Gu, Z., S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death (2002) Science, 297, pp. 1186-1190
Yong, V.W., Power, C., Forsyth, P., Edwards, D.R., Metalloproteinases in biology and pathology of the nervous system (2001) Nature Rev. Neurosci, 2, pp. 502-511
Yao, D., Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity (2004) Proc. Natl Acad. Sci. USA, 101, pp. 10810-10814
Chung, K.K., S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function (2004) Science, 304, pp. 1328-1331
Hara, M. R. et al. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc. Natl Acad. Sci. USA 103, 3887-3889 (2006). This paper describes a GAPDH-SIAH1-mediated pathway for cell death and unravels a new mechanism of action for selegiline, a drug used in the treatment of Parkinson's diseaseUehara, T., S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration (2006) Nature, 441, pp. 513-517
Burnett, A.L., The role of nitric oxide in erectile dysfunction: Implications for medical therapy (2006) J. Clin. Hypertens. (Greenwich), 8 (SUPPL. 4), pp. 53-62
Redington, A.E., Modulation of nitric oxide pathways: Therapeutic potential in asthma and chronic obstructive pulmonary disease (2006) Eur. J. Pharmacol, 533, pp. 263-276
Griffiths, M.J., Evans, T.W., Inhaled nitric oxide therapy in adults (2005) N. Engl. J. Med, 353, pp. 2683-2695
Hemnes, A.R., Champion, H.C., Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension (2006) Expert Rev. Cardiovasc. Ther, 4, pp. 293-300
Butterfield, D., Nutritional approaches to combat oxidative stress in Alzheimer's disease (2002) J. Nutr. Biochem, 13, p. 444
Scapagnini, G., Curcumin activates defensive genes and protects neurons against oxidative stress (2006) Antioxid. Redox Signal, 8, pp. 395-403
Kanski, J., Aksenova, M., Stoyanova, A., Butterfield, D.A., Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: Structure-activity studies (2002) J. Nutr. Biochem, 13, pp. 273-281
Kim, H.S., Inhibitory effects of long-term administration of ferulic acid on microglial activation induced by intracerebroventricular injection of β-amyloid peptide (1-42) in mice (2004) Biol. Pharm. Bull, 27, pp. 120-121
Sultana, R., Ravagna, A., Mohmmad-Abdul, H., Calabrese, V., Butterfield, D.A., Ferulic acid ethyl ester protects neurons against amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity: Relationship to antioxidant activity (2005) J. Neurochem, 92, pp. 749-758
Calabrese, V., Giuffrida Stella, A.M., Calvani, M., Butterfield, D.A., Acetylcarnitine and cellular stress response: Roles in nutritional redox homeostasis and regulation of longevity genes (2006) J. Nutr. Biochem, 17, pp. 73-88
Calabrese, V., Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: Evidence for a protective role of acetylcarnitine (2003) Neurochem. Res, 28, pp. 1321-1328
Abdul, H.M., Calabrese, V., Calvani, M., Butterfield, D.A., Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-β peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease (2006) J. Neurosci. Res, 84, pp. 398-408
De Marchis, S., Modena, C., Peretto, P., Giffard, C., Fasolo, A., Carnosine-like immunoreactivity in the central nervous system of rats during postnatal development (2000) J. Comp. Neurol, 426, pp. 378-390
Calabrese, V., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem. Res, 30, pp. 797-807
Preston, J.E., Hipkiss, A.R., Himsworth, D.T., Romero, I.A., Abbott, J.N., Toxic effects of β-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and β-alanine (1998) Neurosci. Lett, 242, pp. 105-108
Hipkiss, A.R., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann. NY Acad. Sci, 854, pp. 37-53
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell. Mol. Life Sci, 59, pp. 546-551
Joshi, G., Glutathione elevation by ?-glutamylcysteine ethyl ester as a potential therapeutic strategy towards preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implications for chemobrain (2007) J. Neurosci. Res, 85, pp. 497-503
Tangpong, J., Adriamycin-induced, TNF-?-mediated central nervous system toxicity (2006) Neurobiol. Dis, 23, pp. 127-139
Silverman, D.H., Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy (2007) Breast Cancer Res. Treat, 103, pp. 303-311
Rahman, I., Biswas, S.K., Kirkham, P.A., Regulation of inflammation and redox signalling by dietary polyphenols (2006) Biochem. Pharmacol, 72, pp. 1439-1452
Sultana, R., Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: A regional study (2007) J. Cell. Mol. Med, 11, pp. 839-851
Butterfield, D. A. et al. Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiol. Dis. 22, 223-232 (2006). This was the first paper to describe proteomicsidentified oxidatively modified brain proteins in mild cognitive impairment, a precursor to Alzheimer's diseaseSalerno, L., Sorrenti, V., Di Giacomo, C., Romeo, G. & Siracusa, M. A. Progress in the development of selective nitric oxide synthase (NOS) inhibitors. Curr. Pharm. Des. 8, 177-200 (2002). This paper provides useful information about the selectivity of several NOS inhibitorsMejia-Garcia, T.A., Paes-de-Carvalho, R., Nitric oxide regulates cell survival in purified cultures of avian retinal neurons: Involvement of multiple transduction pathways (2007) J. Neurochem, 100, pp. 382-394
Privalle, C., Talarico, T., Keng, T., DeAngelo, J., Pyridoxalated hemoglobin polyoxyethylene: A nitric oxide scavenger with antioxidant activity for the treatment of nitric oxide-induced shock (2000) Free Radic. Biol. Med, 28, pp. 1507-1517
Kaur, H., Interaction of bilirubin and biliverdin with reactive nitrogen species (2003) FEBS Lett, 543, pp. 113-119
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Comparative Study, Research Support, N. I. H. , Extramural, Non-U. S. Gov'T, Review,
Impact factor: 24.52, 5-year impact factor: 26.723
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34648836983&partnerID=40&md5=2445a8b7daad027f5269ca9b66d38e90
Keywords: Acetylcarnitine, Amide, Arginine, Arginine Derivative, Bilirubin, Carbonate Dehydratase Ii, Carnosine, Curcumin, Cyclic Amp Responsive Element Binding Protein, Cyclic Gmp Derivative, Doxorubicin, Endothelial Nitric Oxide Synthase, Ferulic Acid, Heat Shock Protein, Heme Oxygenase, Hemoglobin, Hemoglobin Derivative, Imidazoline Derivative, Inducible Nitric Oxide Synthase, N(g) Nitroarginine Methyl Ester, Neuronal Nitric Oxide Synthase, Nitric Oxide Donor, Nitro Derivative, Ornithine Derivative, Protein Kinase B, Quinoxaline Derivative, Sildenafil, Thiol Derivative, Tumor Necrosis Factor, Alzheimer Disease, Antiinflammatory Activity, Antioxidant Activity, Brain Ischemia, Brain Region, Cell Survival, Central Nervous System, Chronic Fatigue Syndrome, Cognition, Cognitive Defect, Concentration (parameters), Dementia, Depression, Diabetic Neuropathy, Enzyme Localization, Fluid Balance, Human, Human Immunodeficiency Virus Infection, Huntington Chorea, Impotence, Multiple Sclerosis, Nerve Cell Necrosis, Nerve Cell Plasticity, Neuromodulation, Neuroprotection, Neurotoxicity, Neurotransmission, Nitrosative Stress, Nitrosylation, Nonhuman, Oxidation Reduction Reaction, Priority Journal, Protein Expression, Protein Family, Protein Secretion, Proteomics, Pulmonary Hypertension, Reperfusion Injury, Reproduction, Review, Signal Transduction, Sleep Waking Cycle, Somnolence, Animals, Neurodegenerative Diseases, Neuroprotective Agents, Neurotoxicity Syndromes, N (g) Nitroarginine Methyl Ester,
Affiliations:
*** IBB - CNR ***
Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. calabres@unict.it
Institute of Pharmacology, Catholic University School of Medicine, Roma, Italy
Department of Internal Medicine, Catholic University School of Medicine, Roma, Italy
References:
Guix, F. X., Uribesalgo, I., Coma, M. & Munoz, F. J. The physiology and pathophysiology of nitric oxide in the brain. Prog. Neurobiol. 76, 126-152 (2005). A comprehensive review of NO functions in the brainRivier, C. Role of gaseous neurotransmitters in the hypothalamic- pituitary-adrenal axis. Ann. NY Acad. Sci. 933, 254-264 (2001). A useful paper for understanding the controversial action of NO in the regulation of the stress axisMcCann, S.M., The nitric oxide hypothesis of brain aging (1997) Exp. Gerontol, 32, pp. 431-44
Toda, N., Ayajiki, K., Okamura, T., Nitric oxide and penile erectile function (2005) Pharmacol. Ther, 106, pp. 233-266
Takahashi, T., Pathophysiological significance of neuronal nitric oxide synthase in the gastrointestinal tract (2003) J. Gastroenterol, 38, pp. 421-430
Currò, D., Preziosi, P., Non-adrenergic noncholinergic relaxation of the rat stomach (1998) Gen. Pharmacol, 31, pp. 697-703
Pacher, P., Beckman, J.S., Liaudet, L., Nitric oxide and peroxynitrite in health and disease (2007) Physiol. Rev, 87, pp. 315-424
Hirst, D.G., Robson, T., Nitrosative stress in cancer therapy (2007) Front. Biosci, 12, pp. 3406-3418
Ridnour, L.A., The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations (2004) Biol. Chem, 385, pp. 1-10
Sultana, R., Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach (2006) Neurobiol. Dis, 22, pp. 76-87
Castegna A. et al. Proteomic identification of nitrated proteins in Alzheimer's disease brain. J. Neurochem. 85, 1394-1401 (2003). This was the first proteomics study to identify nitrated proteins in the brain of patients with Alzheimer's diseaseBredt, D.S., Endogenous nitric oxide synthesis: Biological functions and pathophysiology (1999) Free Radic. Res, 31, pp. 577-596
Dawson, T. M. & Snyder, S. H. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J. Neurosci. 14, 5147-5159 (1994). This paper provides details on the distribution of nNOS in the CNS and PNSRodrigo, J., Localization of nitric oxide synthase in the adult rat brain (1994) Philos. Trans. R. Soc. Lond. B Biol. Sci, 345, pp. 175-221
Vincent, S.R., Kimura, H., Histochemical mapping of nitric oxide synthase in the rat brain (1992) Neuroscience, 46, pp. 755-784
Bredt, D.S., Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase (1991) Neuron, 7, pp. 615-624
De Giorgio, R., Nitric oxide producing neurons in the monkey and human digestive system (1994) J. Comp. Neurol, 342, pp. 619-627
Magee, T., Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract (1996) Biochem. Biophys. Res. Commun, 226, pp. 145-151
Calabrese, V., Butterfield, D.A., Scapagnini, G., Stella, A.M., Maines, M.D., Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: Relevance to brain aging, neurodegenerative disorders, and longevity (2006) Antioxid. Redox Signal, 8, pp. 444-477
Colasanti, M., Expression of a NOS-III-like protein in human astroglial cell culture (1998) Biochem. Biophys. Res. Commun, 252, pp. 552-555
Rajasekaran, M., Ex vivo expression of nitric oxide synthase isoforms (eNOS/iNOS) and calmodulin in human penile cavernosal cells (1998) J. Urol, 160, pp. 2210-2215
Arnold, W. P., Mittal, C. K., Katsuki, S. & Murad, F. Nitric oxide activates guanylate cyclase and increases guanosine 3?-5?-cyclic monophosphate levels in various tissue preparations. Proc. Natl Acad. Sci. USA 74, 3203-3207 (1977). A milestone paper about the ability of NO to activate sGCKrumenacker, J.S., Hanafy, K.A., Murad, F., Regulation of nitric oxide and soluble guanylyl cyclase (2004) Brain Res. Bull, 62, pp. 505-515
Nakane, M., Soluble guanylyl cyclase: Physiological role as an NO receptor and the potential molecular target for therapeutic application (2003) Clin. Chem. Lab. Med, 41, pp. 865-870
Uretsky, A.D., Weiss, B.L., Yunker, W.K., Chang, J.P., Nitric oxide produced by a novel nitric oxide synthase isoform is necessary for gonadotropin-releasing hormone-induced growth hormone secretion via a cGMP-dependent mechanism (2003) J. Neuroendocrinol, 15, pp. 667-676
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., Salvemini, D., Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors (2005) Pharmacol. Rev, 57, pp. 217-252
Motterlini, R., Green, C.J., Foresti, R., Regulation of heme oxygenase-1 by redox signals involving nitric oxide (2002) Antioxid. Redox Signal, 4, pp. 615-624
Contestabile, A., Ciani, E., Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation (2004) Neurochem. Int, 45, pp. 903-914
Riccio, A. et al. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol. Cell 21, 283-294 (2006). This study demonstrates that the NO pathway controls CREB-DNA binding and CRE-mediated gene expressionFoster, M.W., McMahon, T.J., Stamler, J.S., S-nitrosylation in health and disease (2003) Trends Mol. Med, 9, pp. 160-168
Garthwaite, J., Charles, S. L. & Chess-Williams, R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336, 385-388 (1988). A landmark paper that demonstrates that EDRF, the early name given to NO, is involved in neurotransmissionPalmer, R.M., Ferrige, A.G., Moncada, S., Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor (1987) Nature, 327, pp. 524-526
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E. & Chaudhuri, G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl Acad. Sci. USA 84, 9265-9269 (1987). A milestone paper that reveals the identity of EDRF as NOGarthwaite, J., Boulton, C.L., Nitric oxide signaling in the central nervous system (1995) Annu. Rev. Physiol, 57, pp. 683-706
Sanders, K.M., Ward, S.M., Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission (1992) Am. J. Physiol, 262, pp. G379-G392
Prast, H., Tran, M.H., Fischer, H., Philippu, A., Nitric oxide-induced release of acetylcholine in the nucleus accumbens: Role of cyclic GMP, glutamate, and GABA (1998) J. Neurochem, 71, pp. 266-273
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S., Whitton, P.S., Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo (1996) Brain Res, 717, pp. 196-199
Ohkuma, S., Katsura, M., Chen, D.Z., Narihara, H., Kuriyama, K., Nitric oxide-evoked [3H]γ-aminobutyric acid release is mediated by two distinct release mechanisms (1996) Brain Res. Mol. Brain Res, 36, pp. 137-144
Lonart, G., Wang, J., Johnson, K.M., Nitric oxide induces neurotransmitter release from hippocampal slices (1992) Eur. J. Pharmacol, 220, pp. 271-272
Lorrain, D.S., Hull, E.M., Nitric oxide increases dopamine and serotonin release in the medial preoptic area (1993) Neuroreport, 5, pp. 87-89
Kaehler, S.T., Singewald, N., Sinner, C., Philippu, A., Nitric oxide modulates the release of serotonin in the rat hypothalamus (1999) Brain Res, 835, pp. 346-349
Bon, C.L., Garthwaite, J., On the role of nitric oxide in hippocampal long-term potentiation (2003) J. Neurosci, 23, pp. 1941-1948
Boulton, C.L., Southam, E., Garthwaite, J., Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase (1995) Neuroscience, 69, pp. 699-703
Chien, W.L., Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1- benzylindazole (2003) Mol. Pharmacol, 63, pp. 1322-1328
Hars, B., Endogenous nitric oxide in the rat pons promotes sleep (1999) Brain Res, 816, pp. 209-219
Datta, S., Patterson, E.H., Siwek, D.F., Endogenous and exogenous nitric oxide in the pedunculopontine tegmentum induces sleep (1997) Synapse, 27, pp. 69-78
Cavas, M., Navarro, J.F., Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat (2006) Prog. Neuropsychopharmacol. Biol. Psychiatry, 30, pp. 56-67
Stern, J.E., Nitric oxide and homeostatic control: An intercellular signalling molecule contributing to autonomic and neuroendocrine integration? (2004) Prog. Biophys. Mol. Biol, 84, pp. 197-215
Toni, R., Malaguti, A., Benfenati, F., Martini, L., The human hypothalamus: A morpho-functional perspective (2004) J. Endocrinol. Invest, 27, pp. 73-94
Tsigos, C., Chrousos, G.P., Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress (2002) J. Psychosom. Res, 53, pp. 865-871
Barberis, C., Tribollet, E., Vasopressin and oxytocin receptors in the central nervous system (1996) Crit. Rev. Neurobiol, 10, pp. 119-154
Tringali, G., Aubry, J.M., Navarra, P., Pozzoli, G., Lamotrigine inhibits basal and Na+-stimulated, but not Ca2+-stimulated, release of corticotropin-releasing hormone from the rat hypothalamus (2006) Psychopharmacology (Berl.), 188, pp. 386-392
Costa, A., Trainer, P., Besser, M., Grossman, A., Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro (1993) Brain Res, 605, pp. 187-192
Yasin, S., Nitric oxide modulates the release of vasopressin from rat hypothalamic explants (1993) Endocrinology, 133, pp. 1466-1469
Nguyen, K.T., Exposure to acute stress induces brain interleukin-1β protein in the rat (1998) J. Neurosci, 18, pp. 2239-2246
Karanth, S., Lyson, K., McCann, S.M., Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami (1993) Proc. Natl Acad. Sci. USA, 90, pp. 3383-3387
Rivier, C., Role of nitric oxide in regulating the rat hypothalamic-pituitary-adrenal axis response to endotoxemia (2003) Ann. NY Acad. Sci, 992, pp. 72-85
Kadekaro, M., Nitric oxide modulation of the hypothalamo-neurohypophyseal system (2004) Braz. J. Med. Biol. Res, 37, pp. 441-450
Brann, D.W., Bhat, G.K., Lamar, C.A., Mahesh, V.B., Gaseous transmitters and neuroendocrine regulation (1997) Neuroendocrinology, 65, pp. 385-395
Argiolas, A., Melis, M.R., Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus (2005) Prog. Neurobiol, 76, pp. 1-21
Mancuso, C., Heme oxygenase and its products in the nervous system (2004) Antioxid. Redox Signal, 6, pp. 878-887
Mancuso, C., Inhibition of heme oxygenase in the central nervous system potentiates endotoxin-induced vasopressin release in the rat (1999) J. Neuroimmunol, 99, pp. 189-194
Mancuso, C. et al. Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function. Brain Res. Mol. Brain Res. 50, 267-276 (1997). This was the first paper to provide direct evidence that carbon monoxide is involved in the regulation of vasopressin release from rat hypothalamic explantsPozzoli, G., Carbon monoxide as a novel neuroendocrine modulator: Inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants (1994) Endocrinology, 135, pp. 2314-2317
Jaffrey, S.R., Erdjument-Bromage, H., Ferris, C.D., Tempst, P., Snyder, S.H., Protein S-nitrosylation: A physiological signal for neuronal nitric oxide (2001) Nature Cell Biol, 3, pp. 193-197
Choi, Y.B., Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation (2000) Nature Neurosci, 3, pp. 15-21
Lipton, S.A., Singel, D.J., Stamler, J.S., Nitric oxide in the central nervous system (1994) Prog. Brain Res, 103, pp. 359-364
Mungrue, I.N., Bredt, D.S., nNOS at a glance: Implications for brain and brawn (2004) Cell Sci, 117, pp. 2627-2629
Melino, G., S-nitrosylation regulates apoptosis (1997) Nature, 388, pp. 432-433
Liu, L. & Stamler, J. S. NO: an inhibitor of cell death. Cell Death Differ. 6, 937-942 (1999)Mannick, J.B., S-Nitrosylation of mitochondrial caspases (2001) J. Cell Biol, 154, pp. 1111-1116
Tenneti, L., D'Emilia, D.M., Lipton, S.A., Suppression of neuronal apoptosis by S-nitrosylation of caspases (1997) Neurosci. Lett, 236, pp. 139-142
Zhou, P., Qian, L., Iadecola, C., Nitric oxide inhibits caspase activation and apoptotic morphology but does not rescue neuronal death (2005) J. Cereb. Blood Flow Metab, 25, pp. 348-357
Kitamura, Y., In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: Possible involvement of nitric oxide production from inducible nitric oxide synthase (1998) Glia, 22, pp. 138-148
Mancuso, C., Bonsignore, A., Di Stasio, E., Mordente, A. & Motterlini, R. Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide. Biochem. Pharmacol. 66, 2355-2363 (2003). In this paper, the authors describe the ability of bilirubin to interact with S-nitrosothiolsGood, P.F., Hsu, A., Werner, P., Perl, D.P., Olanow, C.W., Protein nitration in Parkinson's disease (1998) J. Neuropathol. Exp. Neurol, 57, pp. 338-342
Mancuso, C., Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders (2007) Front. Biosci, 12, pp. 1107-1123
Dalle-Donne, I., Scaloni, A. & Butterfield, D. A. (Eds) Redox Proteomics: From Protein Modifications to Cellular Dysfunctions and Diseases (John Wiley & Sons, New Jersey, 2006). A comprehensive treatise on the identification of oxidatively modified proteins in health and diseaseCastegna, A., Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: Dihydropyrimidinase- related protein 2, α-enolase and heat shock cognate 71 (2002) J. Neurochem, 82, pp. 1524-1532
Messier, C., Gagnon, M., Glucose regulation and brain aging (2000) J. Nutr. Health Aging, 4, pp. 208-213
Vanhanen, M., Soininen, H., Glucose intolerance, cognitive impairment and Alzheimer's disease (1998) Curr. Opin. Neurol, 11, pp. 673-677
Ojika, K., Tsugu, Y., Mitake, S., Otsuka, Y., Katada, E., NMDA receptor activation enhances the release of a cholinergic differentiation peptide (HCNP) from hippocampal neurons in vitro (1998) Brain Res. Dev. Brain Res, 106, pp. 173-180
Rossor, M.N., The substantia innominata in Alzheimer's disease: An histochemical and biochemical study of cholinergic marker enzymes (1982) Neurosci. Lett, 28, pp. 217-222
Giacobini, E., Cholinergic function and Alzheimer's disease (2003) Int. J. Geriatr. Psychiatry, 18, pp. S1-S5
Sun, M.K., Alkon, D.L., Carbonic anhydrase gating of attention: Memory therapy and enhancement (2002) Trends Pharmacol. Sci, 23, pp. 83-89
Chuang, D.M., Hough, C., Senatorov, V.V., Glyceraldehyde-3- phosphate dehydrogenase, apoptosis, and neurodegenerative diseases (2005) Annu. Rev. Pharmacol. Toxicol, 45, pp. 269-290
Browne, S.E., Beal, M.F., Oxidative damage in Huntington's disease pathogenesis (2006) Antioxid. Redox Signal, 8, pp. 2061-2073
Gu, Z., S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death (2002) Science, 297, pp. 1186-1190
Yong, V.W., Power, C., Forsyth, P., Edwards, D.R., Metalloproteinases in biology and pathology of the nervous system (2001) Nature Rev. Neurosci, 2, pp. 502-511
Yao, D., Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity (2004) Proc. Natl Acad. Sci. USA, 101, pp. 10810-10814
Chung, K.K., S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function (2004) Science, 304, pp. 1328-1331
Hara, M. R. et al. Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc. Natl Acad. Sci. USA 103, 3887-3889 (2006). This paper describes a GAPDH-SIAH1-mediated pathway for cell death and unravels a new mechanism of action for selegiline, a drug used in the treatment of Parkinson's diseaseUehara, T., S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration (2006) Nature, 441, pp. 513-517
Burnett, A.L., The role of nitric oxide in erectile dysfunction: Implications for medical therapy (2006) J. Clin. Hypertens. (Greenwich), 8 (SUPPL. 4), pp. 53-62
Redington, A.E., Modulation of nitric oxide pathways: Therapeutic potential in asthma and chronic obstructive pulmonary disease (2006) Eur. J. Pharmacol, 533, pp. 263-276
Griffiths, M.J., Evans, T.W., Inhaled nitric oxide therapy in adults (2005) N. Engl. J. Med, 353, pp. 2683-2695
Hemnes, A.R., Champion, H.C., Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension (2006) Expert Rev. Cardiovasc. Ther, 4, pp. 293-300
Butterfield, D., Nutritional approaches to combat oxidative stress in Alzheimer's disease (2002) J. Nutr. Biochem, 13, p. 444
Scapagnini, G., Curcumin activates defensive genes and protects neurons against oxidative stress (2006) Antioxid. Redox Signal, 8, pp. 395-403
Kanski, J., Aksenova, M., Stoyanova, A., Butterfield, D.A., Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: Structure-activity studies (2002) J. Nutr. Biochem, 13, pp. 273-281
Kim, H.S., Inhibitory effects of long-term administration of ferulic acid on microglial activation induced by intracerebroventricular injection of β-amyloid peptide (1-42) in mice (2004) Biol. Pharm. Bull, 27, pp. 120-121
Sultana, R., Ravagna, A., Mohmmad-Abdul, H., Calabrese, V., Butterfield, D.A., Ferulic acid ethyl ester protects neurons against amyloid β-peptide (1-42)-induced oxidative stress and neurotoxicity: Relationship to antioxidant activity (2005) J. Neurochem, 92, pp. 749-758
Calabrese, V., Giuffrida Stella, A.M., Calvani, M., Butterfield, D.A., Acetylcarnitine and cellular stress response: Roles in nutritional redox homeostasis and regulation of longevity genes (2006) J. Nutr. Biochem, 17, pp. 73-88
Calabrese, V., Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: Evidence for a protective role of acetylcarnitine (2003) Neurochem. Res, 28, pp. 1321-1328
Abdul, H.M., Calabrese, V., Calvani, M., Butterfield, D.A., Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-β peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease (2006) J. Neurosci. Res, 84, pp. 398-408
De Marchis, S., Modena, C., Peretto, P., Giffard, C., Fasolo, A., Carnosine-like immunoreactivity in the central nervous system of rats during postnatal development (2000) J. Comp. Neurol, 426, pp. 378-390
Calabrese, V., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem. Res, 30, pp. 797-807
Preston, J.E., Hipkiss, A.R., Himsworth, D.T., Romero, I.A., Abbott, J.N., Toxic effects of β-amyloid (25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and β-alanine (1998) Neurosci. Lett, 242, pp. 105-108
Hipkiss, A.R., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann. NY Acad. Sci, 854, pp. 37-53
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell. Mol. Life Sci, 59, pp. 546-551
Joshi, G., Glutathione elevation by ?-glutamylcysteine ethyl ester as a potential therapeutic strategy towards preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implications for chemobrain (2007) J. Neurosci. Res, 85, pp. 497-503
Tangpong, J., Adriamycin-induced, TNF-?-mediated central nervous system toxicity (2006) Neurobiol. Dis, 23, pp. 127-139
Silverman, D.H., Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy (2007) Breast Cancer Res. Treat, 103, pp. 303-311
Rahman, I., Biswas, S.K., Kirkham, P.A., Regulation of inflammation and redox signalling by dietary polyphenols (2006) Biochem. Pharmacol, 72, pp. 1439-1452
Sultana, R., Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: A regional study (2007) J. Cell. Mol. Med, 11, pp. 839-851
Butterfield, D. A. et al. Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiol. Dis. 22, 223-232 (2006). This was the first paper to describe proteomicsidentified oxidatively modified brain proteins in mild cognitive impairment, a precursor to Alzheimer's diseaseSalerno, L., Sorrenti, V., Di Giacomo, C., Romeo, G. & Siracusa, M. A. Progress in the development of selective nitric oxide synthase (NOS) inhibitors. Curr. Pharm. Des. 8, 177-200 (2002). This paper provides useful information about the selectivity of several NOS inhibitorsMejia-Garcia, T.A., Paes-de-Carvalho, R., Nitric oxide regulates cell survival in purified cultures of avian retinal neurons: Involvement of multiple transduction pathways (2007) J. Neurochem, 100, pp. 382-394
Privalle, C., Talarico, T., Keng, T., DeAngelo, J., Pyridoxalated hemoglobin polyoxyethylene: A nitric oxide scavenger with antioxidant activity for the treatment of nitric oxide-induced shock (2000) Free Radic. Biol. Med, 28, pp. 1507-1517
Kaur, H., Interaction of bilirubin and biliverdin with reactive nitrogen species (2003) FEBS Lett, 543, pp. 113-119
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.
At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that this gaseous molecule is involved in the regulation of the cardiovascular, immune and nervous systems, rather than simply being a toxic pollutant. In the CNS, nitric oxide has an array of functions, such as the regulation of synaptic plasticity, the sleep-wake cycle and hormone secretion. Particularly interesting is the role of nitric oxide as a Janus molecule in the cell death or survival mechanisms in brain cells. In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic.
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
No results. |
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
Other filter: ([btitle,keywords] "Acetylcarnitine" OR ...
Altug C, Gunes H, Nocentini A, Monti SM, Buonanno M, Supuran CT
* Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties (277 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017 Feb 15; 25(4): 1456-1464.
Impact Factor: 2.881
View Export to BibTeX Export to EndNote
Angapelly S, Ramya PVS, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M
* Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors (241 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017; 25(2): 539-544.
Impact Factor: 2.881
View Export to BibTeX Export to EndNote
D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G
* Out of the active site binding pocket for carbonic anhydrase inhibitors (360 views) (PDF 234 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2015 Jan 7; 51(2): 302-305.
Impact Factor: 6.567
View Export to BibTeX Export to EndNote
Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A
* Recent developments of carbonic anhydrase inhibitors as potential drugs (392 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141), 2015; 2015: 174178-174178.
Impact Factor: 2.134
View Export to BibTeX Export to EndNote
Di Fiore A, Alterio V, Monti SM, De Simone G, D’Ambrosio K
* Thermostable carbonic anhydrases in biotechnological applications (449 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(7): 15456-15480.
Impact Factor: 3.257
View Export to BibTeX Export to EndNote
De Simone G, Alterio V, Supuran CT
* Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (439 views)
Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
Impact Factor: 3.467
View Export to BibTeX Export to EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (415 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (350 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
View Export to BibTeX Export to EndNote
D'Ambrosio K, Smaine F-Z, Carta F, De Simone G, Winum J-Y, Supuran CT
* Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups (440 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012; 55(15): 6776-6783.
Impact Factor: 5.614
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (394 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (349 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (432 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (536 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
De Simone G, Scozzafava A, Supuran CT
* Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (333 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321.
Impact Factor: 2.473
View Export to BibTeX Export to EndNote
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (421 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
* Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (350 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (429 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (447 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
View Export to BibTeX Export to EndNote
D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (348 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Mar; 3(3): 473-477.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (323 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
View Export to BibTeX Export to EndNote
Chiechio S, Copani A, Gereau R, Nicoletti F
* Acetyl-l-carnitine in neuropathic pain (263 views)
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
Impact Factor: 4.514
View Export to BibTeX Export to EndNote
De Simone G, Supuran CT
* Antiobesity carbonic anhydrase inhibitors (422 views)
Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
Impact Factor: 4.325
View Export to BibTeX Export to EndNote
Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (909 views)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (466 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (386 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (478 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Apr 1; 15(7): 1937-1942.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct (345 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Impact Factor: 0.47
View Export to BibTeX Export to EndNote
* Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties (277 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017 Feb 15; 25(4): 1456-1464.
Impact Factor: 2.881
View Export to BibTeX Export to EndNote
Angapelly S, Ramya PVS, Angeli A, Monti SM, Buonanno M, Alvala M, Supuran CT, Arifuddin M
* Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors (241 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017; 25(2): 539-544.
Impact Factor: 2.881
View Export to BibTeX Export to EndNote
D'Ambrosio K, Carradori S, Monti SM, Buonanno M, Secci D, Vullo D, Supuran CT, De Simone G
* Out of the active site binding pocket for carbonic anhydrase inhibitors (360 views) (PDF 234 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2015 Jan 7; 51(2): 302-305.
Impact Factor: 6.567
View Export to BibTeX Export to EndNote
Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A
* Recent developments of carbonic anhydrase inhibitors as potential drugs (392 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141), 2015; 2015: 174178-174178.
Impact Factor: 2.134
View Export to BibTeX Export to EndNote
Di Fiore A, Alterio V, Monti SM, De Simone G, D’Ambrosio K
* Thermostable carbonic anhydrases in biotechnological applications (449 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(7): 15456-15480.
Impact Factor: 3.257
View Export to BibTeX Export to EndNote
De Simone G, Alterio V, Supuran CT
* Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (439 views)
Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
Impact Factor: 3.467
View Export to BibTeX Export to EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (415 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (350 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
View Export to BibTeX Export to EndNote
D'Ambrosio K, Smaine F-Z, Carta F, De Simone G, Winum J-Y, Supuran CT
* Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups (440 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012; 55(15): 6776-6783.
Impact Factor: 5.614
View Export to BibTeX Export to EndNote
Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (394 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
View Export to BibTeX Export to EndNote
Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (349 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
View Export to BibTeX Export to EndNote
Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (432 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (536 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
De Simone G, Scozzafava A, Supuran CT
* Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates? (333 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2009 Sep; 74(3): 317-321.
Impact Factor: 2.473
View Export to BibTeX Export to EndNote
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (421 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT
* Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (350 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 Apr 1; 18(7): 2267-2271.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (429 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (447 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
View Export to BibTeX Export to EndNote
D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: Binding of indanesulfonamides to the human isoform II (348 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Mar; 3(3): 473-477.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (323 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
View Export to BibTeX Export to EndNote
Chiechio S, Copani A, Gereau R, Nicoletti F
* Acetyl-l-carnitine in neuropathic pain (263 views)
Cns Drugs (ISSN: 1172-7047), 2007; 21: 38-38.
Impact Factor: 4.514
View Export to BibTeX Export to EndNote
De Simone G, Supuran CT
* Antiobesity carbonic anhydrase inhibitors (422 views)
Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
Impact Factor: 4.325
View Export to BibTeX Export to EndNote
Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (909 views)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (466 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (386 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
Di Fiore A, De Simone G, Menchise V, Pedone C, Casini A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II (478 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Apr 1; 15(7): 1937-1942.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli A, Cicerano U, Mansi L, De Chiara S, Gallotta G, Schettini G, Salvatore M
Effect of acute administration of l-acetyl carnitine on cerebral blood flow in patients with chronic cerebral infarct (345 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic, 1043-6618linking), 1991 Apr; 23(3): 241-246.
Impact Factor: 0.47
View Export to BibTeX Export to EndNote
27 Records (25 excluding Abstracts).
Total impact factor: 104.598 (94.969 excluding Abstracts).
Total 5 year impact factor: 104.252 (94.438 excluding Abstracts).
Total impact factor: 104.598 (94.969 excluding Abstracts).
Total 5 year impact factor: 104.252 (94.438 excluding Abstracts).
628 views. Last view on Wednesday 05 October 2022, 6:22:20
ibb.cnr.it