Protective effect of orally administered carnosine on bleomycin-induced lung injury (575 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Export to BibTeX Export to EndNote
Paper type: Abstract, Conference, Research Support, Non-U. S. Gov'T,
Impact factor: 4.214, 5-year impact factor: 4.258
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34250751153&partnerID=40&md5=f78f3cbcd75f740af47201face8abeef
Keywords: Chelating Agent, Lung Fibrosis, Oxidative Stress, 3 Nitrotyrosine, Bleomycin, Carnosine, Collagen, Inducible Nitric Oxide Synthase, Myeloperoxidase, Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase, Transforming Growth Factor Beta, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Apoptosis, Article, Cell Count, Comparative Study, Controlled Study, Drug Efficacy, Enzyme Activity, Enzyme Analysis, Histology, Immunohistochemistry, Leukocyte Differential Count, Lung Edema, Lung Infiltrate, Lung Injury, Lung Lavage, Mortality, Mouse, Neutrophil, Nick End Labeling, Nonhuman, Pneumonia, Priority Journal, Weight Reduction, Wild Type, Administration, Biopsy, Inflammation, Pulmonary Fibrosis,
Affiliations:
*** IBB - CNR ***
Department of Internal Medicine and Specialistic Medicine, Section of Respiratory Diseases, University of Catania, Catania, Italy
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi Bonino-Pulejo, Messina, Italy
Department of Chemical Sciences, University of Catania, Catania, Italy
Institute of Biostructures and Bioimages, Consiglio Nazionale Delle Ricerche, Catania, Italy
Dept. of Internal Medicine and Specialistic Medicine, Respiratory Diseases Section, Univ. of Catania, Via Passo Gravina, 187, 95125 Catania, Italy
References:
Idiopathic pulmonary fibrosis: Diagnosis and treatment International consensus statement American Thoracic Society (ATS), and the European Respiratory Society (ERS) (2000) Am J Respir Crit Care Med, 161, pp. 646-664. , American Thoracic Societ
Ashcroft, T., Simpson, J.M., Timbrell, V., Simple method of estimating severity of pulmonary fibrosis on a numerical scale (1988) J Clin Pathol, 41, pp. 467-470
Babizhayev, M.A., Deyev, A.I., Yermakova, V.N., Semiletov, Y.A., Davydova, N.G., Kurysheva, N.I., Zhukotskii, A.V., Goldman, I.M., N-acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts (2001) Peptides, 22, pp. 979-994
Beckman, J.S., Oxidative damage and tyrosine nitration from peroxynitrite (1996) Chem Res Toxicol, 9, pp. 836-844
Benjamin, R.C., Gill, D.M., Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks (1980) J Biol Chem, 255, pp. 10502-10508
Bonomo, R., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, F., Nicoletti, F., Vecchio, G., Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (2003) J Chem Soc Dalton, pp. 4406-4415
Bonomo, R., Impellizzeri, G., La Mendola, D., Maccarrone, G., Pappalardo, G., Santoro, G., Tabbi, G., Rizzarelli, E., (2003) Functional Mimics of Cu,Zn-Superoxide Dismutase Enzymes, pp. 39-61. , Dordrecht: Kluwer
Brewer, G.J., Copper control as an antiangiogenic anticancer therapy: Lessons from treating Wilson's disease (2001) Exp Biol Med (Maywood), 226, pp. 665-673
Brewer, G.J., Anticopper therapy against cancer and diseases of inflammation and fibrosis (2005) Drug Discov Today, 10, pp. 1103-1109
Brewer, G.J., Dick, R., Ullenbruch, M.R., Jin, H., Phan, S.H., Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis (2004) J Inorg Biochem, 98, pp. 2160-2167
Brewer, G.J., Hedera, P., Kluin, K.J., Carlson, M., Askari, F., Dick, R.B., Sitterly, J., Fink, J.K., Treatment of Wilson disease with ammonium tetrathiomolybdate. III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy (2003) Arch Neurol, 60, pp. 379-385
Calabrese, V., Colombrita, C., Guagliano, E., Sapienza, M., Ravagna, A., Cardile, V., Scapagnini, G., Rizzarelli, E., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem Res, 30, pp. 797-807
Chua, F., Gauldie, J., Laurent, G.J., Pulmonary fibrosis: Searching for model answers (2005) Am J Respir Cell Mol Biol, 33, pp. 9-13
Cosi, C., Marien, M., Implication of poly (ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism. Decreases in mouse brain NAD+ and ATP caused by MPTP are prevented by the PARP inhibitor benzamide (1999) Ann NY Acad Sci, 890, pp. 227-239,227-239
Cuzzocrea, S., Ianaro, A., Wayman, N.S., Mazzon, E., Pisano, B., Dugo, L., Serraino, I., Thiemermann, C., The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat (2003) Br J Pharmacol, 138, pp. 678-688
Cuzzocrea, S., Zingarelli, B., Hake, P., Salzman, A.L., Szabo, C., Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation (1998) Free Radic Biol Med, 24, pp. 450-459
Decker, E.A., Livisay, S.A., Zhou, S., A re-evaluation of the antioxidant activity of purified carnosine (2000) Biochemistry (Mosc), 65, pp. 766-770
Eiserich, J.P., Hristova, M., Cross, C.E., Jones, A.D., Freeman, B.A., Halliwell, B., van d V. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils (1998) Nature, 391, pp. 393-397
Fattman, C.L., Chang, L.Y., Termin, T.A., Petersen, L., Enghild, J.J., Oury, T.D., Enhanced bleomycin-induced pulmonary damage in mice lacking extracellular superoxide dismutase (2003) Free Radic Biol Med, 35, pp. 763-771
Filderman, A.E., Genovese, L.A., Lazo, J.S., Alterations in pulmonary protective enzymes following systemic bleomycin treatment in mice (1988) Biochem Pharmacol, 37, pp. 1111-1116
Fine, A., Goldstein, R.H., The effect of transforming growth factor-β on cell proliferation and collagen formation by lung fibroblasts (1987) J Biol Chem, 262, pp. 3897-3902
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Goodman, V.L., Brewer, G.J., Merajver, S.D., Copper deficiency as an anti-cancer strategy (2004) Endocr Relat Cancer, 11, pp. 255-263
Green, F.H., Overview of pulmonary fibrosis (2002) Chest, 122, pp. 334S-339S
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Hipkiss, A.R., Worthington, V.C., Himsworth, D.T., Herwig, W., Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite (1998) Biochim Biophys Acta, 1380, pp. 46-54
Hoyt, D.G., Lazo, J.S., Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-β precede bleomycin-induced pulmonary fibrosis in mice (1988) J Pharmacol Exp Ther, 246, pp. 765-771
Hubbard, A.K., Timblin, C.R., Shukla, A., Rincon, M., Mossman, B.T., Activation of NF-κB-dependent gene expression by silica in lungs of luciferase reporter mice (2002) Am J Physiol Lung Cell Mol Physiol, 282, pp. L968-L975
Janssen B, Hohenadel D, Brinkkoetter P, Peters V, Rind N, Fischer C, Rychlik I, Cerna M, Romzova M, de HE, Baelde H, Bakker SJ, Zirie M, Rondeau E, Mathieson P, Saleem MA, Meyer J, Koppel H, Sauerhoefer S, Bartram CR, Nawroth P, Hammes HP, Yard BA, Zschocke J, van der Woude FJ. Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. Diabetes 54: 2320-2327, 2005Kang, J.H., Kim, K.S., Choi, S.Y., Kwon, H.Y., Won, M.H., Kang, T.C., Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radical-mediated modification (2002) Mol Cell, 13, pp. 498-502
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Lane, T.F., Iruela-Arispe, M.L., Johnson, R.S., Sage, E.H., SPARC is a source of copper-binding peptides that stimulate angiogenesis (1994) J Cell Biol, 125, pp. 929-943
Latsi, P.I., du Bois, R.M., Nicholson, A.G., Colby, T.V., Bisirtzoglou, D., Nikolakopoulou, A., Veeraraghavan, S., Wells, A.U., Fibrotic idiopathic interstitial pneumonia: The prognostic value of longitudinal functional trends (2003) Am J Respir Crit Care Med, 168, pp. 531-537
Lee, Y.T., Hsu, C.C., Lin, M.H., Liu, K.S., Yin, M.C., Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation (2005) Eur J Pharmacol, 513, pp. 145-150
Mastruzzo, C., Crimi, N., Vancheri, C., Role of oxidative stress in pulmonary fibrosis (2002) Monaldi Arch Chest Dis, 57, pp. 173-176
McCall, T.B., Boughton-Smith, N.K., Palmer, R.M., Whittle, B.J., Moncada, S., Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion (1989) Biochem J, 261, pp. 293-296
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Mullane, K.M., Kraemer, R., Smith, B., Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium (1985) J Pharmacol Methods, 14, pp. 157-167
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Pron, G., Belehradek Jr, J., Orlowski, S., Mir, L.M., Involvement of membrane bleomycin-binding sites in bleomycin cytotoxicity (1994) Biochem Pharmacol, 48, pp. 301-310
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Romanska, H.M., Polak, J.M., Coleman, R.A., James, R.S., Harmer, D.W., Allen, J.C., Bishop, A.E., iNOS gene upregulation is associated with the early proliferative response of human lung fibroblasts to cytokine stimulation (2002) J Pathol, 197, pp. 372-379
Saleh, D., Barnes, P.J., Giaid, A., Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis (1997) Am J Respir Crit Care Med, 155, pp. 1763-1769
Selman, M., King, T.E., Pardo, A., Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy (2001) Ann Intern Med, 134, pp. 136-151
Sleijfer, S., Bleomycin-induced pneumonitis (2001) Chest, 120, pp. 617-624
Son, D.O., Satsu, H., Kiso, Y., Shimizu, M., Characterization of carnosine uptake and its physiological function in human intestinal epithelial Caco-2 cells (2004) Biofactors, 21, pp. 395-398
Sporn, M.B., Roberts, A.B., Wakefield, L.M., de, C.B., Some recent advances in the chemistry and biology of transforming growth factor-β (1987) J Cell Biol, 105, pp. 1039-1045
Virag, L., Poly(ADP-ribosyl)ation in asthma and other lung diseases (2005) Pharmacol Res, 52, pp. 83-92
Wei, X.Q., Charles, I.G., Smith, A., Ure, J., Feng, G.J., Huang, F.P., Xu, D., Liew, F.Y., Altered immune responses in mice lacking inducible nitric oxide synthase (1995) Nature, 375, pp. 408-411
Weiss, S.J., Tissue destruction by neutrophils (1989) N Engl J Med, 320, pp. 365-376
Babizhayev, M. A., Deyev, A. I., Yermakova, V. N., Semiletov, Y. A., Davydova, N. G., Kurysheva, N. I., Zhukotskii, A. V., Goldman, I. M., N-acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts (2001) Peptides, 22, pp. 979-994
Beckman, J. S., Oxidative damage and tyrosine nitration from peroxynitrite (1996) Chem Res Toxicol, 9, pp. 836-844
Benjamin, R. C., Gill, D. M., Poly (ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks (1980) J Biol Chem, 255, pp. 10502-10508
Brewer, G. J., Copper control as an antiangiogenic anticancer therapy: Lessons from treating Wilson's disease (2001) Exp Biol Med (Maywood), 226, pp. 665-673
Brewer, G. J., Anticopper therapy against cancer and diseases of inflammation and fibrosis (2005) Drug Discov Today, 10, pp. 1103-1109
Brewer, G. J., Dick, R., Ullenbruch, M. R., Jin, H., Phan, S. H., Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis (2004) J Inorg Biochem, 98, pp. 2160-2167
Brewer, G. J., Hedera, P., Kluin, K. J., Carlson, M., Askari, F., Dick, R. B., Sitterly, J., Fink, J. K., Treatment of Wilson disease with ammonium tetrathiomolybdate. III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy (2003) Arch Neurol, 60, pp. 379-385
Decker, E. A., Livisay, S. A., Zhou, S., A re-evaluation of the antioxidant activity of purified carnosine (2000) Biochemistry (Mosc), 65, pp. 766-770
Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., van d V. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils (1998) Nature, 391, pp. 393-397
Fattman, C. L., Chang, L. Y., Termin, T. A., Petersen, L., Enghild, J. J., Oury, T. D., Enhanced bleomycin-induced pulmonary damage in mice lacking extracellular superoxide dismutase (2003) Free Radic Biol Med, 35, pp. 763-771
Filderman, A. E., Genovese, L. A., Lazo, J. S., Alterations in pulmonary protective enzymes following systemic bleomycin treatment in mice (1988) Biochem Pharmacol, 37, pp. 1111-1116
Goodman, M. T., Hernandez, B., Wilkens, L. R., Lee, J., Le, M. L., Liu, L. Q., Franke, A. A., Hsu, T. C., Effects of -carotene and -tocopherol on bleomycin-induced chromosomal damage (1998) Cancer Epidemiol Biomarkers Prev, 7, pp. 113-117
Goodman, V. L., Brewer, G. J., Merajver, S. D., Copper deficiency as an anti-cancer strategy (2004) Endocr Relat Cancer, 11, pp. 255-263
Green, F. H., Overview of pulmonary fibrosis (2002) Chest, 122, pp. 334S-339S
Hipkiss, A. R., Worthington, V. C., Himsworth, D. T., Herwig, W., Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite (1998) Biochim Biophys Acta, 1380, pp. 46-54
Hoyt, D. G., Lazo, J. S., Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor- precede bleomycin-induced pulmonary fibrosis in mice (1988) J Pharmacol Exp Ther, 246, pp. 765-771
Hubbard, A. K., Timblin, C. R., Shukla, A., Rincon, M., Mossman, B. T., Activation of NF- B-dependent gene expression by silica in lungs of luciferase reporter mice (2002) Am J Physiol Lung Cell Mol Physiol, 282, pp. L968-L975
Lane, T. F., Iruela-Arispe, M. L., Johnson, R. S., Sage, E. H., SPARC is a source of copper-binding peptides that stimulate angiogenesis (1994) J Cell Biol, 125, pp. 929-943
Latsi, P. I., du Bois, R. M., Nicholson, A. G., Colby, T. V., Bisirtzoglou, D., Nikolakopoulou, A., Veeraraghavan, S., Wells, A. U., Fibrotic idiopathic interstitial pneumonia: The prognostic value of longitudinal functional trends (2003) Am J Respir Crit Care Med, 168, pp. 531-537
Lee, Y. T., Hsu, C. C., Lin, M. H., Liu, K. S., Yin, M. C., Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation (2005) Eur J Pharmacol, 513, pp. 145-150
McCall, T. B., Boughton-Smith, N. K., Palmer, R. M., Whittle, B. J., Moncada, S., Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion (1989) Biochem J, 261, pp. 293-296
Mullane, K. M., Kraemer, R., Smith, B., Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium (1985) J Pharmacol Methods, 14, pp. 157-167
Quinn, P. J., Boldyrev, A. A., Formazuyk, V. E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Mol Aspects Med, 13, pp. 379-444
Romanska, H. M., Polak, J. M., Coleman, R. A., James, R. S., Harmer, D. W., Allen, J. C., Bishop, A. E., iNOS gene upregulation is associated with the early proliferative response of human lung fibroblasts to cytokine stimulation (2002) J Pathol, 197, pp. 372-379
Son, D. O., Satsu, H., Kiso, Y., Shimizu, M., Characterization of carnosine uptake and its physiological function in human intestinal epithelial Caco-2 cells (2004) Biofactors, 21, pp. 395-398
Sporn, M. B., Roberts, A. B., Wakefield, L. M., de, C. B., Some recent advances in the chemistry and biology of transforming growth factor- (1987) J Cell Biol, 105, pp. 1039-1045
Virag, L., Poly (ADP-ribosyl) ation in asthma and other lung diseases (2005) Pharmacol Res, 52, pp. 83-92
Wei, X. Q., Charles, I. G., Smith, A., Ure, J., Feng, G. J., Huang, F. P., Xu, D., Liew, F. Y., Altered immune responses in mice lacking inducible nitric oxide synthase (1995) Nature, 375, pp. 408-411
Weiss, S. J., Tissue destruction by neutrophils (1989) N Engl J Med, 320, pp. 365-376
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Export to BibTeX Export to EndNote
Paper type: Abstract, Conference, Research Support, Non-U. S. Gov'T,
Impact factor: 4.214, 5-year impact factor: 4.258
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-34250751153&partnerID=40&md5=f78f3cbcd75f740af47201face8abeef
Keywords: Chelating Agent, Lung Fibrosis, Oxidative Stress, 3 Nitrotyrosine, Bleomycin, Carnosine, Collagen, Inducible Nitric Oxide Synthase, Myeloperoxidase, Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase, Transforming Growth Factor Beta, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Apoptosis, Article, Cell Count, Comparative Study, Controlled Study, Drug Efficacy, Enzyme Activity, Enzyme Analysis, Histology, Immunohistochemistry, Leukocyte Differential Count, Lung Edema, Lung Infiltrate, Lung Injury, Lung Lavage, Mortality, Mouse, Neutrophil, Nick End Labeling, Nonhuman, Pneumonia, Priority Journal, Weight Reduction, Wild Type, Administration, Biopsy, Inflammation, Pulmonary Fibrosis,
Affiliations:
*** IBB - CNR ***
Department of Internal Medicine and Specialistic Medicine, Section of Respiratory Diseases, University of Catania, Catania, Italy
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi Bonino-Pulejo, Messina, Italy
Department of Chemical Sciences, University of Catania, Catania, Italy
Institute of Biostructures and Bioimages, Consiglio Nazionale Delle Ricerche, Catania, Italy
Dept. of Internal Medicine and Specialistic Medicine, Respiratory Diseases Section, Univ. of Catania, Via Passo Gravina, 187, 95125 Catania, Italy
References:
Idiopathic pulmonary fibrosis: Diagnosis and treatment International consensus statement American Thoracic Society (ATS), and the European Respiratory Society (ERS) (2000) Am J Respir Crit Care Med, 161, pp. 646-664. , American Thoracic Societ
Ashcroft, T., Simpson, J.M., Timbrell, V., Simple method of estimating severity of pulmonary fibrosis on a numerical scale (1988) J Clin Pathol, 41, pp. 467-470
Babizhayev, M.A., Deyev, A.I., Yermakova, V.N., Semiletov, Y.A., Davydova, N.G., Kurysheva, N.I., Zhukotskii, A.V., Goldman, I.M., N-acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts (2001) Peptides, 22, pp. 979-994
Beckman, J.S., Oxidative damage and tyrosine nitration from peroxynitrite (1996) Chem Res Toxicol, 9, pp. 836-844
Benjamin, R.C., Gill, D.M., Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks (1980) J Biol Chem, 255, pp. 10502-10508
Bonomo, R., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, F., Nicoletti, F., Vecchio, G., Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (2003) J Chem Soc Dalton, pp. 4406-4415
Bonomo, R., Impellizzeri, G., La Mendola, D., Maccarrone, G., Pappalardo, G., Santoro, G., Tabbi, G., Rizzarelli, E., (2003) Functional Mimics of Cu,Zn-Superoxide Dismutase Enzymes, pp. 39-61. , Dordrecht: Kluwer
Brewer, G.J., Copper control as an antiangiogenic anticancer therapy: Lessons from treating Wilson's disease (2001) Exp Biol Med (Maywood), 226, pp. 665-673
Brewer, G.J., Anticopper therapy against cancer and diseases of inflammation and fibrosis (2005) Drug Discov Today, 10, pp. 1103-1109
Brewer, G.J., Dick, R., Ullenbruch, M.R., Jin, H., Phan, S.H., Inhibition of key cytokines by tetrathiomolybdate in the bleomycin model of pulmonary fibrosis (2004) J Inorg Biochem, 98, pp. 2160-2167
Brewer, G.J., Hedera, P., Kluin, K.J., Carlson, M., Askari, F., Dick, R.B., Sitterly, J., Fink, J.K., Treatment of Wilson disease with ammonium tetrathiomolybdate. III. Initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy (2003) Arch Neurol, 60, pp. 379-385
Calabrese, V., Colombrita, C., Guagliano, E., Sapienza, M., Ravagna, A., Cardile, V., Scapagnini, G., Rizzarelli, E., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem Res, 30, pp. 797-807
Chua, F., Gauldie, J., Laurent, G.J., Pulmonary fibrosis: Searching for model answers (2005) Am J Respir Cell Mol Biol, 33, pp. 9-13
Cosi, C., Marien, M., Implication of poly (ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism. Decreases in mouse brain NAD+ and ATP caused by MPTP are prevented by the PARP inhibitor benzamide (1999) Ann NY Acad Sci, 890, pp. 227-239,227-239
Cuzzocrea, S., Ianaro, A., Wayman, N.S., Mazzon, E., Pisano, B., Dugo, L., Serraino, I., Thiemermann, C., The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat (2003) Br J Pharmacol, 138, pp. 678-688
Cuzzocrea, S., Zingarelli, B., Hake, P., Salzman, A.L., Szabo, C., Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation (1998) Free Radic Biol Med, 24, pp. 450-459
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Filderman, A. E., Genovese, L. A., Lazo, J. S., Alterations in pulmonary protective enzymes following systemic bleomycin treatment in mice (1988) Biochem Pharmacol, 37, pp. 1111-1116
Goodman, M. T., Hernandez, B., Wilkens, L. R., Lee, J., Le, M. L., Liu, L. Q., Franke, A. A., Hsu, T. C., Effects of -carotene and -tocopherol on bleomycin-induced chromosomal damage (1998) Cancer Epidemiol Biomarkers Prev, 7, pp. 113-117
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Hipkiss, A. R., Worthington, V. C., Himsworth, D. T., Herwig, W., Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite (1998) Biochim Biophys Acta, 1380, pp. 46-54
Hoyt, D. G., Lazo, J. S., Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor- precede bleomycin-induced pulmonary fibrosis in mice (1988) J Pharmacol Exp Ther, 246, pp. 765-771
Hubbard, A. K., Timblin, C. R., Shukla, A., Rincon, M., Mossman, B. T., Activation of NF- B-dependent gene expression by silica in lungs of luciferase reporter mice (2002) Am J Physiol Lung Cell Mol Physiol, 282, pp. L968-L975
Lane, T. F., Iruela-Arispe, M. L., Johnson, R. S., Sage, E. H., SPARC is a source of copper-binding peptides that stimulate angiogenesis (1994) J Cell Biol, 125, pp. 929-943
Latsi, P. I., du Bois, R. M., Nicholson, A. G., Colby, T. V., Bisirtzoglou, D., Nikolakopoulou, A., Veeraraghavan, S., Wells, A. U., Fibrotic idiopathic interstitial pneumonia: The prognostic value of longitudinal functional trends (2003) Am J Respir Crit Care Med, 168, pp. 531-537
Lee, Y. T., Hsu, C. C., Lin, M. H., Liu, K. S., Yin, M. C., Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation (2005) Eur J Pharmacol, 513, pp. 145-150
McCall, T. B., Boughton-Smith, N. K., Palmer, R. M., Whittle, B. J., Moncada, S., Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion (1989) Biochem J, 261, pp. 293-296
Mullane, K. M., Kraemer, R., Smith, B., Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium (1985) J Pharmacol Methods, 14, pp. 157-167
Quinn, P. J., Boldyrev, A. A., Formazuyk, V. E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Mol Aspects Med, 13, pp. 379-444
Romanska, H. M., Polak, J. M., Coleman, R. A., James, R. S., Harmer, D. W., Allen, J. C., Bishop, A. E., iNOS gene upregulation is associated with the early proliferative response of human lung fibroblasts to cytokine stimulation (2002) J Pathol, 197, pp. 372-379
Son, D. O., Satsu, H., Kiso, Y., Shimizu, M., Characterization of carnosine uptake and its physiological function in human intestinal epithelial Caco-2 cells (2004) Biofactors, 21, pp. 395-398
Sporn, M. B., Roberts, A. B., Wakefield, L. M., de, C. B., Some recent advances in the chemistry and biology of transforming growth factor- (1987) J Cell Biol, 105, pp. 1039-1045
Virag, L., Poly (ADP-ribosyl) ation in asthma and other lung diseases (2005) Pharmacol Res, 52, pp. 83-92
Wei, X. Q., Charles, I. G., Smith, A., Ure, J., Feng, G. J., Huang, F. P., Xu, D., Liew, F. Y., Altered immune responses in mice lacking inducible nitric oxide synthase (1995) Nature, 375, pp. 408-411
Weiss, S. J., Tissue destruction by neutrophils (1989) N Engl J Med, 320, pp. 365-376
Protective effect of orally administered carnosine on bleomycin-induced lung injury
Carnosine is an endogenously synthesized dipeptide composed of β-alanine and L-histidine. It acts as a free radical scavenger and possesses antioxidant properties. Carnosine reduces proinflammatory and profibrotic cytokines such as transforming growth factor-β (TGF-β), IL-1, and TNF-α in different experimental settings. In the present study, we investigated the efficacy of carnosine on the animal model of bleomycin-induced lung injury. Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg. One week after fibrosis induction, bronchoalveolar lavage (BAL) cell counts and TGF-β levels, lung histology, and immunohistochemical analyses for myeloperoxidase, TGF-β, inducible nitric oxide synthase, nitrotyrosine, and poly(ADP-ribose) polymerase were performed. Finally, apoptosis was quantified by terminal deoxynucleotidyltransferase- mediated UTP end-labeling assay. After bleomycin administration, carnosine-treated mice exhibited a reduced degree of lung damage and inflammation compared with wild-type mice, as shown by the reduction of 1) body weight, 2) mortality rate, 3) lung infiltration by neutrophils (myeloperoxidase activity and BAL total and differential cell counts), 4) lung edema, 5) histological evidence of lung injury and collagen deposition, 6) lung myeloperoxidase, TGF-β, inducible nitric oxide synthase, nitrotyrosine, and poly(ADP-ribose) polymerase immunostaining, 7) BAL TGF-β levels, and 8) apoptosis. Our results indicate that orally administered carnosine is able to prevent bleomycin-induced lung injury likely through its direct antioxidant properties. Carnosine is already available for human use. It might prove useful as an add-on therapy for the treatment of fibrotic disorders of the lung where oxidative stress plays a role, such as for idiopathic pulmonary fibrosis, a disease that still represents a major challenge to medical treatment. Copyright © 2007 the American Physiological Society.
Carnosine is an endogenously synthesized dipeptide composed of β-alanine and L-histidine. It acts as a free radical scavenger and possesses antioxidant properties. Carnosine reduces proinflammatory and profibrotic cytokines such as transforming growth factor-β (TGF-β), IL-1, and TNF-α in different experimental settings. In the present study, we investigated the efficacy of carnosine on the animal model of bleomycin-induced lung injury. Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg. One week after fibrosis induction, bronchoalveolar lavage (BAL) cell counts and TGF-β levels, lung histology, and immunohistochemical analyses for myeloperoxidase, TGF-β, inducible nitric oxide synthase, nitrotyrosine, and poly(ADP-ribose) polymerase were performed. Finally, apoptosis was quantified by terminal deoxynucleotidyltransferase- mediated UTP end-labeling assay. After bleomycin administration, carnosine-treated mice exhibited a reduced degree of lung damage and inflammation compared with wild-type mice, as shown by the reduction of 1) body weight, 2) mortality rate, 3) lung infiltration by neutrophils (myeloperoxidase activity and BAL total and differential cell counts), 4) lung edema, 5) histological evidence of lung injury and collagen deposition, 6) lung myeloperoxidase, TGF-β, inducible nitric oxide synthase, nitrotyrosine, and poly(ADP-ribose) polymerase immunostaining, 7) BAL TGF-β levels, and 8) apoptosis. Our results indicate that orally administered carnosine is able to prevent bleomycin-induced lung injury likely through its direct antioxidant properties. Carnosine is already available for human use. It might prove useful as an add-on therapy for the treatment of fibrotic disorders of the lung where oxidative stress plays a role, such as for idiopathic pulmonary fibrosis, a disease that still represents a major challenge to medical treatment. Copyright © 2007 the American Physiological Society.
Protective effect of orally administered carnosine on bleomycin-induced lung injury
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Protective effect of orally administered carnosine on bleomycin-induced lung injury
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* Renal cells from spermatogonial germline stem cells protect against kidney injury (354 views)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (562 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (171 views)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
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Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, Palmieri G
* RedOx status, proteasome and APEH: Insights into anticancer mechanisms of t10, c12-conjugated linoleic acid isomer on A375 melanoma cells (716 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 19; 8(11): N/D-N/D.
Impact Factor: 3.534
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Savi L, Ribaldone DG, Fagoonee S, Pellicano R
* Is Helicobacter pylori the infectious trigger for headache?: A review (246 views)
Infect Disord Drug Targets (ISSN: 2212-3989electronic, 1871-5265linking), 2013 Oct; 13(5): 313-317.
Impact Factor: 0
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Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (460 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
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Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
* Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (366 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
Impact Factor: 2.689
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine derivatives: new multifunctional drug-like molecules (549 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Jul; 43(1): 153-163.
Impact Factor: 3.914
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3606 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (385 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
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Di Fiore A, Maresca A, Supuran CT, De Simone G
* Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (361 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
Impact Factor: 6.378
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (550 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (606 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (881 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (424 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (555 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Rachidi W, De Rosa V
Selenium protects against the cytotoxic and genotoxic effects of oxidative stress both as an anti-oxidant and by stimulating DNA damage repair (306 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2011 Mar; 98: N/D-N/D.
Impact Factor: 0.672
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (402 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (429 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (554 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (613 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
Impact Factor: 3.787
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Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (429 views)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
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De Rosa V, Diamond A, Favier A, Douki T, Rachidi W
* Effect of selenium on lethal and genotoxic properties of oxidative stress (206 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2010 Mar; 97: N/D-N/D.
Impact Factor: 0.887
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Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E
* Carnosinase levels in aging brain: redox state induction and cellular stress response (445 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Impact Factor: 7.581
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (533 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Montella S, Santamaria F, Salvatore M, Pignata C, Maglione M, Iacotucci P, Mollica C
* Assessment of chest high-field magnetic resonance imaging in children and young adults with noncystic fibrosis chronic lung disease: comparison to high-resolution computed tomography and correlation with pulmonary function (233 views)
Invest Radiol (ISSN: 1536-0210, 0020-9996, 1536-0210electronic), 2009 Sep; 44(9): 532-538.
Impact Factor: 4.85
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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De Rosa V, Alan D, Alain F, Thierry D, Walid R
* The anticancer effect of selenium: study of its role in DNA repair activity and resistance to oxidative stress (250 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2009 Mar; 96: N/D-N/D.
Impact Factor: 0.792
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1145 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1232 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (831 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (405 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
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Limauro D, Pedone E, Galdi I, Bartolucci S
* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (366 views)
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
Impact Factor: 3.139
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (753 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (553 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (554 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
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Pedone E, Limauro D, D'Alterio R, Rossi M, Bartolucci S
* Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus (328 views)
Febs Journal (ISSN: 1742-464x), 2006 Dec; 273(23): 5407-5420.
Impact Factor: 3.033
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (596 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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Limauro D, Pedone E, Pirone L, Bartolucci S
* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (362 views)
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
Impact Factor: 3.033
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Pedone E, Bartolucci S, Fiorentino G
* Sensing and adapting to environmental stress: The Archaeal tactic (327 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2004 Sep 1; 9: 2909-2926.
Impact Factor: 3.226
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (642 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (323 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (911 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (689 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (564 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
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Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (351 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
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Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates (336 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1997 Apr 25; 272(17): 11147-11151.
Impact Factor: 6.963
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (691 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (526 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (489 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
Impact Factor: 1.342
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* Targeting Mitochondrial Therapy in the Regulation of HPV Infection and HPV-Related Cancers (6 views)
Pathogens, 2023 Mar; 12(3): 402-417.
Impact Factor: 4.531
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Fatima N, Baqri SSR, Alsulimani A, Fagoonee S, Slama P, Kesari KK, Roychoudhury S, Haque S
* Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer (3 views)
Antioxidants (ISSN: 2076-3921linking), 2021 Oct 13; 10 (10 ): N/D-N/D.
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La Manna S, Lopez-sanz L, Bernal S, Fortuna S, Mercurio FA, Leone M, Gomez-guerrero C, Marasco D
* Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics (22 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2021 Oct 5; 221: 113547-113547.
Impact Factor: 5.572
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Pedone E, Fiorentino G, Bartolucci S, Limauro D
* Enzymatic Antioxidant Signatures in Hyperthermophilic Archaea (57 views)
Antioxidants (ISSN: 2076-3921linking), 2020 Aug 3; 9(8): N/D-N/D.
Impact Factor: 4.52
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (114 views) (PDF 85 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Jan 4; 9(1): N/D-N/D.
Impact Factor: 5.688
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Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E
* Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna (91 views)
Aquat Toxicol (ISSN: 0166-445xlinking), 2018 May; 198: 158-164.
Impact Factor: 0
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Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (708 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Monti DM, De Simone G, Langella E, Supuran CT, Di Fiore A, Monti SM
* Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage (354 views)
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2017 Dec; 32(1): 5-12.
Impact Factor: 3.638
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Dell'Acqua S, Bacchella C, Monzani E, Nicolis S, Di Natale G, Rizzarelli E, Casella L
* Prion Peptides Are Extremely Sensitive to Copper Induced Oxidative Stress (585 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Sep 18; 56(18): 11317-11325.
Impact Factor: 4.7
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Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E
* Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress (167 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking), 2017 Jul; 108: 452-464.
Impact Factor: 6.02
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Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E
* Data demonstrating the anti-oxidant role of hemopexin in the heart (163 views)
Data Brief (ISSN: 2352-3409print, 2352-3409linking), 2017 May 13; 13: 69-76.
Impact Factor: 0
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Soprano M, Sorriento D, Rusciano MR, Maione AS, Limite G, Forestieri P, D'Angelo D, D'Alessio M, Campiglia P, Formisano P, Iaccarino G, Bianco R, Illario M
* Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells (249 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2016 Jun 9; 11(6): e0155970-e0155970.
Impact Factor: 2.806
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Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (262 views)
Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315.
Impact Factor: 0
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Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (720 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.
Impact Factor: 3.348
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Cella L, D'Avino V, Palma G, Conson M, Liuzzi R, Picardi M, Pressello MC, Boboc GI, Battistini R, Donato V, Pacelli R
* Modeling the risk of radiation-induced lung fibrosis: Irradiated heart tissue is as important as irradiated lung (400 views) (PDF 197 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 0167-8140linking), 2015 Aug 12; 117(1): 36-43.
Impact Factor: 4.817
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Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
* Combination of Abeta Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC (353 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (590 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
* Renal cells from spermatogonial germline stem cells protect against kidney injury (354 views)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (562 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine and Cognitive Deficits (171 views)
Diet And Nutr In Dement And Cogn Decline (ISSN: 9780-1240793979780124078246), 2014; N/D: 973-982.
Impact Factor: 0
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Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, Palmieri G
* RedOx status, proteasome and APEH: Insights into anticancer mechanisms of t10, c12-conjugated linoleic acid isomer on A375 melanoma cells (716 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 19; 8(11): N/D-N/D.
Impact Factor: 3.534
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Savi L, Ribaldone DG, Fagoonee S, Pellicano R
* Is Helicobacter pylori the infectious trigger for headache?: A review (246 views)
Infect Disord Drug Targets (ISSN: 2212-3989electronic, 1871-5265linking), 2013 Oct; 13(5): 313-317.
Impact Factor: 0
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Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (460 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
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Del Giudice R, Monti DM, Truppo E, Arciello A, Supuran CT, De Simone G, Monti SM
* Human Carbonic Anhydrase Vii Protects Cells From Oxidative Damage (366 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1431-1673, 1437-4315), 2013; 394(10): 1343-1348.
Impact Factor: 2.689
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Bellia F, Vecchio G, Rizzarelli E
* Carnosine derivatives: new multifunctional drug-like molecules (549 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Jul; 43(1): 153-163.
Impact Factor: 3.914
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3606 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (385 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
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Di Fiore A, Maresca A, Supuran CT, De Simone G
* Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (361 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
Impact Factor: 6.378
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (550 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (606 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (881 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (424 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (555 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Rachidi W, De Rosa V
Selenium protects against the cytotoxic and genotoxic effects of oxidative stress both as an anti-oxidant and by stimulating DNA damage repair (306 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2011 Mar; 98: N/D-N/D.
Impact Factor: 0.672
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (402 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (429 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (554 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (613 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
Impact Factor: 3.787
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Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (429 views)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
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De Rosa V, Diamond A, Favier A, Douki T, Rachidi W
* Effect of selenium on lethal and genotoxic properties of oxidative stress (206 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2010 Mar; 97: N/D-N/D.
Impact Factor: 0.887
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Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E
* Carnosinase levels in aging brain: redox state induction and cellular stress response (445 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Impact Factor: 7.581
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (533 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Montella S, Santamaria F, Salvatore M, Pignata C, Maglione M, Iacotucci P, Mollica C
* Assessment of chest high-field magnetic resonance imaging in children and young adults with noncystic fibrosis chronic lung disease: comparison to high-resolution computed tomography and correlation with pulmonary function (233 views)
Invest Radiol (ISSN: 1536-0210, 0020-9996, 1536-0210electronic), 2009 Sep; 44(9): 532-538.
Impact Factor: 4.85
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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De Rosa V, Alan D, Alain F, Thierry D, Walid R
* The anticancer effect of selenium: study of its role in DNA repair activity and resistance to oxidative stress (250 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2009 Mar; 96: N/D-N/D.
Impact Factor: 0.792
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1145 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1232 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (831 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (405 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
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Limauro D, Pedone E, Galdi I, Bartolucci S
* Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4 (366 views)
Febs Journal (ISSN: 1742-464x), 2008 May; 275(9): 2067-2077.
Impact Factor: 3.139
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (753 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (553 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
* Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage (554 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jan 12; 282(2): 831-835.
Impact Factor: 5.581
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Pedone E, Limauro D, D'Alterio R, Rossi M, Bartolucci S
* Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus (328 views)
Febs Journal (ISSN: 1742-464x), 2006 Dec; 273(23): 5407-5420.
Impact Factor: 3.033
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (596 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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Limauro D, Pedone E, Pirone L, Bartolucci S
* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (362 views)
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
Impact Factor: 3.033
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Pedone E, Bartolucci S, Fiorentino G
* Sensing and adapting to environmental stress: The Archaeal tactic (327 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2004 Sep 1; 9: 2909-2926.
Impact Factor: 3.226
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (642 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (323 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (911 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (689 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (564 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
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Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (351 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
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Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates (336 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1997 Apr 25; 272(17): 11147-11151.
Impact Factor: 6.963
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (691 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (526 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Condorelli G, Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
INHIBITION OF PHOTOHEMOLYSIS BY COPPER(II) COMPLEXES WITH SOD-LIKE ACTIVITY (489 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1994 Jun; 54(4): 257-265.
Impact Factor: 1.342
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82 Records (76 excluding Abstracts).
Total impact factor: 300.694 (274.36 excluding Abstracts).
Total 5 year impact factor: 302.144 (274.297 excluding Abstracts).
Total impact factor: 300.694 (274.36 excluding Abstracts).
Total 5 year impact factor: 302.144 (274.297 excluding Abstracts).
575 views. Last view on Friday 24 March 2023, 1:47:52
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