Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1387 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Review,
Impact factor: 2.26, 5-year impact factor: 2.312
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-56449129616&partnerID=40&md5=562023959b9b30042cb52deb8fad5fa6
Keywords: Aging, Antioxidants, Cellular Stress Response, Neurodegenerative Disorders, Redox Homeostasis, Vitagenes, Carnitine, Carnosine, Curcumin, Heat Shock Protein 10, Heme Oxygenase 1, Immunoglobulin Enhancer Binding Protein, Levacecarnine, Messenger Rna, Reactive Oxygen Metabolite, Resveratrol, Sirtuin, Thioredoxin, Thioredoxin Reductase, Alzheimer Disease, Caloric Intake, Cell Survival, Chemoprophylaxis, Diet Restriction, Disorders Of Mitochondrial Functions, Friedreich Ataxia, Gene Mutation, Genetic Code, Human, Longevity, Nerve Degeneration, Neuroprotection, Nonhuman, Nutritional Assessment, Oxidative Stress, Parkinson Disease, Priority Journal, Protein Folding, Review, Animals, Neurodegenerative Diseases, Reactive Oxygen Species,
Affiliations:
*** IBB - CNR ***
Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Viale Andrea Doria 6, 95100, Catania, Italy. calabres@unict.it
Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
Department of Neurosciences, University of Catania, Catania, Italy
University Department of Clinical Neurosciences, Institute of Neurology, University College London, Rowland Hill Street, London NW3 2PF, United Kingdom
School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom
Division of Clinical Pharmacology, Departments of Medicine and Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
Biomedical Research Centre, University of Dundee, United Kingdom
References:
Halliwell, B., Oxidative stress and cancer: Have we moved forward? (2007) Biochem J, 401, pp. 1-1
Calabrese, V., Scapagnini, G., Colombrita, C., Ravagna, A., Pennisi, G., Giuffrida Stella, A.M., Galli, F., Butterfield, D.A., Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: A nutritional approach (2003) Amino Acids, 25, pp. 437-444
Poon, H.F., Calabrese, V., Scapagnini, G., Butterfield, D.A., Free radicals: Key to brain aging and heme oxygenase as a cellular response to oxidative stress (2004) J Gerontology, 59, pp. 478-493
Forman, H.J., Fukuto, J.M., Torres, M., Redox signaling: Thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers (2004) Am J Physiol Cell Physiol, 287, pp. 246-256
Calabrese, V., Giuffrida Stella, A.M., Butterfield, D.A., Scapagnini, G., Redox regulation in neurodegeneration and longevity: Role of the heme oxygenase and HSP70 systems in brain stress tolerance (2004) Antioxid Redox Signal, 6, pp. 895-913
Halliwell, B., Hypothesis: Proteasomal dysfunction: A primary event in neurogeneration that leads to nitrative and oxidative stress and subsequent cell death (2002) Ann NY Acad Sci, 962, pp. 182-194
Martindale, J.L., Holbrook, N.J., Cellular response to oxidative stress: Signaling for suicide and survival (2002) J Cell Physiol, 192, pp. 1-15
Bergamini, C.M., Gambetti, S., Dondi, A., Cervellati, C., Oxygen, reactive oxygen species and tissue damage (2004) Curr Pharm des, 10, pp. 1611-1626
Pappolla, M.A., Chyan, Y.J., Omar, R.A., Hsiao, K., Perry, G., Smith, M.A., Bozner, P., Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo (1998) Am J Pathol, 152, pp. 871-877
Smith, M.A., Hirai, K., Hsiao, K., Pappolla, M.A., Harris, P.L., Siedlak, S.L., Tabaton, M., Perry, G., Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress (1998) J Neurochem, 70, pp. 2212-2215
Butterfield, D.A., Drake, J., Pocernich, C., Castegna, A., Evidence of oxidative damage in Alzheimer's disease brain: Central role for amyloid beta-peptide (2001) Trends Mol Med, 7, pp. 548-554
Mattson, M.P., Pathways towards and away from Alzheimer's disease (2004) Nature, 430, pp. 631-639
Drew, B., Leeuwenburgh, C., Aging and the role of reactive nitrogen species (2002) Ann NY Acad Sci, 959, pp. 66-81
Kroncke, K.D., Nitrosative stress and transcription (2003) Biol Chem, 384, pp. 1365-1377
Ridnour, L.A., Thomas, D.D., Mancardi, D., Espey, M.G., Miranda, K.M., Paolocci, N., Feelisch, M., Wink, D.A., The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations (2004) Biol Chem, 385, pp. 1-10
Calabrese, V., Guagliano, E., Sapienza, M., Panebianco, M., Calafato, S., Puleo, E., Pennisi, G., Stella, A.G., Redox regulation of cellular stress response in aging and neurodegenerative disorders: Role of vitagenes (2007) Neurochem Res, 32, pp. 757-773
Calabrese, V., Boyd-Kimball, D., Scapagnini, G., Butterfield, D.A., Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: The role of vitagenes (2004) In Vivo, 18, pp. 245-267
Mancuso, C., Scapagnini, G., Curro, D., Giuffrida Stella, A.M., De Marco, C., Butterfield, D.A., Calabrese, V., Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders (2007) Front Biosci, 12, pp. 1107-1123
Vina, J., Borras, C., Gomez-Cabrera, M.C., Orr, W.C., Part of the series: From dietary antioxidants to regulators in cellular signalling and gene expression. Role of reactive oxygen species and (phyto)oestrogens in the modulation of adaptive response to stress (2006) Free Radic Res, 40, pp. 111-119
McCord, J.M., Fridovich, I., Superoxide dismutase: The first twenty years (1968-1988) (1988) Free Radic Biol Med, 5, pp. 363-369
Calabrese, E.J., Staudenmayer, J.W., Stanek, E.J., Drug development and hormesis: Changing conceptual understanding of the dose response creates new challenges and opportunities for more effective drugs (2006) Curr Opin Drug Discov Devel, 9, pp. 117-123
Zhang, K., Kaufman, R.J., The unfolded protein response: A stress signaling pathway critical for health and disease (2006) Neurology, 66, pp. 102-109
Calabrese, V., Butterfield, D.A., Scapagnini, G., Stella, A.M., Maines, M.D., Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: Relevance to brain aging, neurodegenerative disorders, and longevity (2006) Antioxid Redox Signal, 8, pp. 444-477
Maines, M.D., The heme oxygenase system: A regulator of second messenger gases (1997) Annu Rev Pharmacol Toxicol, 37, pp. 517-554
Mancuso, C., Heme oxygenase and its products in the nervous system (2004) Antioxid Redox Signal, 6, pp. 878-887
Stocker, R., Antioxidant activities of bile pigments (2004) Antioxid Redox Signal, 6, pp. 841-849
Mancuso, C., Pani, G., Calabrese, V., Bilirubin: An endogenous scavenger of nitric oxide and reactive nitrogen species (2006) Redox Rep, 11, pp. 207-213
Mancuso, C., Bonsignore, A., Capone, C., Di Stasio, E., Pani, G., Albumin-bound bilirubin interacts with nitric oxide by a redox mechanism (2006) Antioxid Redox Signal, 8, pp. 487-494
Simonian, N.A., Coyle, J.T., Oxidative stress in neurodegenerative diseases (1996) Annu Rev Pharmacol Toxicol, 36, pp. 83-106
Sayre, L.M., Smith, M.A., Perry, G., Chemistry and biochemistry of oxidative stress in neurodegenerative disease (2001) Curr Med Chem, 8, pp. 721-738
Andersen, J.K., Oxidative stress in neurodegeneration: Cause or consequence? (2004) Nat Med, 10, pp. 18-25
Mancuso, C., Perluigi, M., Cini, C., De Marco, C., Giuffrida Stella, A.M., Calabrese, V., Heme oxygenase and cyclooxygenase in the central nervous system: A functional interplay (2006) J Neurosci Res, 84, pp. 1385-1391
Panahian, N., Yoshiura, M., Maines, M.D., Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice (1999) J Neurochem, 72, pp. 1187-1203
Takeda, A., Perry, G., Abraham, N.G., Dwyer, B.E., Kutty, R.K., Laitinen, J.T., Petersen, R.B., Smith, M.A., Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau (2000) J Biol Chem, 275, pp. 5395-5399
Premkumar, D.R., Smith, M.A., Richey, P.L., Petersen, R.B., Castellani, R., Kutty, R.K., Wiggert, B., Kalaria, R.N., Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease (1995) J Neurochem, 65, pp. 1399-1402
Schipper, H.M., Heme oxygenase-1: Role in brain aging and neurodegeneration (2000) Exp Gerontol, 35, pp. 821-830
Mancuso, C., Bates, T.E., Butterfield, D.A., Calafato, S., Cornelius, C., De Lorenzo, A., Dinkova Kostova, A.T., Calabrese, V., Natural antioxidants in Alzheimer's disease (2007) Expert Opin Investig Drugs, 16, pp. 1921-1931
Butterfield, D., Castegna, A., Pocernich, C., Drake, J., Scapagnini, G., Calabrese, V., Nutritional approaches to combat oxidative stress in Alzheimer's disease (2002) J Nutr Biochem, 13, pp. 444-461
Ganguli, M., Chandra, V., Kamboh, M.I., Johnston, J.M., Dodge, H.H., Thelma, B.K., Juyal, R.C., Dekosky, S.T., Apolipoprotein e polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study (2000) Arch Neurol, 57, pp. 824-830
Lim, G.P., Chu, T., Yang, F., Beech, W., Frautschy, S.A., Cole, G.M., The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse (2001) J Neurosci, 21, pp. 8370-8377
Wu, L., Wang, R., Carbon monoxide: Endogenous production, physiological functions, and pharmacological applications (2005) Pharmacol Rev, 57, pp. 585-630
Kostoglou-Athanassiou, I., Forsling, M.L., Navarra, P., Grossman, A.B., Oxytocin release is inhibited by the generation of carbon monoxide from the rat hypothalamus-further evidence for carbon monoxide as a neuromodulator (1996) Brain Res Mol Brain Res, 42, pp. 301-306
Mancuso, C., Kostoglou-Athanassiou, I., Forsling, M.L., Grossman, A.B., Preziosi, P., Navarra, P., Minotti, G., Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants, molecular linkage between heme catabolism and neuroendocrine function (1997) Brain Res Mol Brain Res, 50, pp. 267-276
Mancuso, C., Ragazzoni, E., Tringali, G., Liberale, I., Preziosi, P., Grossman, A., Navarra, P., Inhibition of heme oxygenase in the central nervous system potentiates endotoxin-induced vasopressin release in the rat (1999) J Neuroimmunol, 99, pp. 189-194
Parkes, D., Kasckow, J., Vale, W., Carbon monoxide modulates secretion of corticotropin-releasing factor from rat hypothalamic cell cultures (1994) Brain Res, 646, pp. 315-318
Pozzoli, G., Mancuso, C., Mirtella, A., Preziosi, P., Grossman, A.B., Navarra, P., Carbon monoxide as a novel neuroendocrine modulator: Inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants (1994) Endocrinology, 135, pp. 2314-2317
Mancuso, C., Pistritto, G., Tringali, G., Grossman, A.B., Preziosi, P., Navarra, P., Evidence that carbon monoxide stimulates prostaglandin endoperoxide synthase activity in rat hypothalamic explants and in primary cultures of rat hypothalamic astrocytes (1997) Brain Res Mol Brain Res, 45, pp. 294-300
Mancuso, C., Tringali, G., Grossman, A., Preziosi, P., Navarra, P., The generation of nitric oxide and carbon monoxide produces opposite effects on the release of immunoreactive interleukin-1beta from the rat hypothalamus in vitro: Evidence for the involvement of different signaling pathways (1998) Endocrinology, 139, pp. 1031-1037
Jaggar, J.H., Leffler, C.W., Cheranov, S.Y., Tcheranova, D., Shuyu, E., Cheng, X., Carbon monoxide dilates cerebral arterioles by enhancing the coupling of Ca2+ sparks to Ca2+-activated K+ channels (2002) Circ Res, 91, pp. 610-617
Otterbein, L.E., Bach, F.H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R.J., Choi, A.M., Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway (2000) Nat Med, 6, pp. 422-428
Ryter, S.W., Otterbein, L.E., Morse, D., Choi, A.M., Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance (2002) Mol Cell Biochem, 234-235, pp. 249-263
Yenari, M.A., Giffard, R.G., Sapolsky, R.M., Steinberg, G.K., The neuroprotective potential of heat shock protein 70 (HSP70) (1999) Mol Med Today, 5, pp. 525-531
Kelly, S., Zhang, Z.J., Zhao, H., Xu, L., Giffard, R.G., Sapolsky, R.M., Yenari, M.A., Steinberg, G.K., Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: Influence of Bcl-2 (2002) Ann Neurol, 52, pp. 160-167
Narasimhan, P., Swanson, R.A., Sagar, S.M., Sharp, F.R., Astrocyte survival and HSP70 heat shock protein induction following heatshock and acidosis (1996) Glia, 17, pp. 147-159
Fink, S.L., Chang, L.K., Ho, D.Y., Sapolsky, R.M., Defective herpes simplex virus vectors expressing the rat brain stress-inducible heat shock protein 72 protect cultured neurons from severe heat shock (1997) J Neurochem, 68, pp. 961-969
Hata, R., Maeda, K., Hermann, D., Mies, G., Hossmann, K.A., Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice (2000) J Cereb Blood Flow Metab, 20, pp. 306-315
Perez, N., Sugar, J., Charya, S., Johnson, G., Merril, C., Bierer, L., Perl, D., Wallace, W., Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease (1991) Brain Res Mol Brain Res, 11, pp. 249-254
Yoo, B.C., Seidl, R., Cairns, N., Lubec, G., Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease (1999) J Neural Transm Suppl, 57, pp. 315-322
Morrison-Bogorad, M., Zimmerman, A.L., Pardue, S., Heat-shock 70 messenger RNA levels in human brain: Correlation with agonal fever (1995) J Neurochem, 64, pp. 235-246
Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Shimohama, S., Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins (2002) FASEB J, 16, pp. 601-603
Calabrese, V., Testa, G., Ravagna, A., Bates, T.E., Stella, A.M., HSP70 induction in the brain following ethanol administration in the rat: Regulation by glutathione redox state (2000) Biochem Biophys Res Commun, 269, pp. 397-400
Calabrese, V., Bates, T.E., Giuffrida Stella, A.M., NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: The role of oxidant/antioxidant balance (2000) Neurochem Res, 65, pp. 1315-1341
Yamawaki, H., Haendeler, J., Berk, B.C., Thioredoxin: A key regulator of cardiovascular homeostasis (2003) Circ Res, 93, pp. 1029-1033
Cho, C.G., Kim, H.J., Chung, S.W., Jung, K.J., Shim, K.H., Yu, B.P., Yodoi, J., Chung, H.Y., Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process (2003) Exp Gerontol, 38, pp. 539-548
Arner, E.S., Holmgren, A., Physiological functions of thioredoxin and thioredoxin reductase (2000) Eur J Biochem, 267, pp. 6102-6109
Sun, Q.A., Kirnarsky, L., Sherman, S., Gladyshev, V.N., Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems (2001) Proc Natl Acad Sci USA, 98, pp. 3673-3678
Bloomfield, K.L., Osborne, S.A., Kennedy, D.D., Clarke, F.M., Tonissen, K.F., Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter (2003) Gene, 319, pp. 107-116
Kim, Y.C., Yamaguchi, Y., Kondo, N., Masutani, H., Yodoi, J., Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response (2003) Oncogene, 22, pp. 1860-1865
Tanito, M., Masutani, H., Kim, Y.C., Nishikawa, M., Ohira, A., Yodoi, J., Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice (2005) Invest Ophthalmol Vis Sci Mar, 46, pp. 979-987
Eftekharpour, E., Holmgren, A., Juurlink, B.H., Thioredoxin reductase and glutathione synthesis is upregulated by t-butylhydroquinone in cortical astrocytes but not in cortical neurons (2000) Glia, 31, pp. 241-248
Hintze, K.J., Wald, K.A., Zeng, H., Jeffery, E.H., Finley, J.W., Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element (2003) J Nutr, 133, pp. 2721-2727
Dinkova-Kostova, A.T., Cheah, J., Samouilov, A., Zweier, J.L., Bozak, R.E., Hicks, R.J., Talalay, P., Phenolic Michael reaction acceptors: Combined direct and indirect antioxidant defenses against electrophiles and oxidants (2007) Med Chem, 3, pp. 261-268
Sakurai, A., Nishimoto, M., Himeno, S., Imura, N., Tsujimoto, M., Kunimoto, M., Hara, S., Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF-E2-related factor-2 (2005) J Cell Physiol, 203, pp. 529-537
Hirota, K., Nakamura, H., Masutani, H., Yodoi, J., Thioredoxin superfamily and thioredoxin-inducing agents (2002) Ann NY Acad Sci, 957, pp. 189-199
Baker, A.F., Dragovich, T., Tate, W.R., Ramanathan, R.K., Roe, D., Hsu, C.H., Kirkpatrick, D.L., Powis, G., The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma (2006) J Lab Clin Med, 147, pp. 83-90
Nakamura, H., Bai, J., Nishinaka, Y., Ueda, S., Sasada, T., Ohshio, G., Imamura, M., Yodoi, J., Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer (2000) Cancer Detect Prev, 24, pp. 53-60
Haapasalo, H., Kylaniemi, M., Paunul, N., Kinnula, V.L., Soini, Y., Expression of antioxidant enzymes in astrocytic brain tumors (2003) Brain Pathol, 13, pp. 155-164
Berggren, M.M., Powis, G., Alternative splicing is associated with decreased expression of the redox proto-oncogene thioredoxin-1 in human cancers (2001) Arch Biochem Biophys, 389, pp. 144-149
Biaglow, J.E., Miller, R.A., The thioredoxin reductase/thioredoxin system: Novel redox targets for cancer therapy (2005) Cancer Biol Ther, 4, pp. 6-13
Bai, J., Nakamura, H., Kwon, Y.W., Hattori, I., Yamaguchi, Y., Kim, Y.C., Kondo, N., Yodoi, J., Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells (2003) J Neurosci, 23, pp. 503-509
Masutani, H., Bai, J., Kim, Y.C., Yodoi, J., Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection (2004) Mol Neurobiol, 29, pp. 229-242
Trigona, W.L., Mullarky, I.K., Cao, Y., Sordillo, L.M., Thioredoxin reductase regulates the induction of heme oxygenase-1 expression in aortic endothelial cells (2006) Biochem J, 394, pp. 207-216
Satoh, T., Ishige, K., Sagara, Y., Protective effects on neuronal cells of mouse afforded by ebselen against oxidative stress at multiple steps (2004) Neurosci Lett, 371, pp. 1-5
Das, K.C., Das, C.K., Thioredoxin, a singlet oxygen quencher and hydroxyl radical scavenger: Redox independent functions (2000) Biochem Biophys Res Commun, 277, pp. 443-447
Ju, T.C., Chen, S.D., Liu, C.C., Yang, D.I., Protective effects of S-nitrosoglutathione against amyloid beta-peptide neurotoxicity (2005) Free Radic Biol Med, 38, pp. 938-949
Rauhala, P., Andoh, T., Yeh, K., Chiueh, C.C., Contradictory effects of sodium nitroprusside and S-nitroso-N- acetylpenicillamine on oxidative stress in brain dopamine neurons in vivo (2002) Ann NY Acad Sci, 962, pp. 60-72
Lee, S.Y., Andoh, T., Murphy, D.L., Chiueh, C.C., 17beta-estradiol activates ICI 182, 780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection (2003) FASEB J, 17, pp. 947-948
Westphal, C.H., Dipp, M.A., Guarente, L., A therapeutic role for sirtuins in diseases of aging? (2007) Trends Biochem Sci, 32, pp. 555-560
Salminen, A., Ojala, J., Huuskonen, J., Kauppinen, A., Suuronen, T., Kaarniranta, K., Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1 (2008) Cell Mol Life Sci, 65, pp. 1049-1058
Dali-Youcef, N., Lagouge, M., Froelich, S., Koehl, C., Schoonjans, K., Auwerx, J., Sirtuins: The 'magnificent seven', function, metabolism and longevity (2007) Ann Med, 39, pp. 335-345
Martin, B., Mattson, M.P., Maudsley, S., Caloric restriction and intermittent fasting: Two potential diets for successful brain aging (2006) Ageing Res Rev, 5, pp. 332-353
Mattson, M.P., Hormesis defined (2008) Ageing Res Rev, 7, pp. 1-7
Giannakou, M.E., Goss, M., Jacobson, J., Vinti, G., Leevers, S.J., Partridge, L., Dynamics of the action of dFOXO on adult mortality in Drosophila (2007) Aging Cell, 6, pp. 429-438
Guarente, L., Picard, F., Calorie restriction-SIR2 connection (2005) Cell, 120, pp. 473-482
Rodgers, J.T., Lerin, C., Haas, W., Cygi, S.P., Spiegelman, B.M., Puigserver, P., Nutrient control of glucose homeostasis through a complex of PGC-1and SIRT1 (2005) Nature, 434, pp. 113-118
Wang, F., Nguyen, M., Qin, F.X., Tong, Q., SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction (2007) Aging Cell, 6, pp. 505-514
Yang, T., Sauve, A.A., NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity (2006) AAPS J, 8, pp. 632-643
Smith, J., Human Sir2 and the 'silencing' of p53 activity (2002) Trends Cell Biol, 12, pp. 404-406
Hipkiss, A.R., Energy metabolism, altered proteins, sirtuins and ageing: Converging mechanisms? (2008) Biogerontology, 9, pp. 49-55
Hipkiss, A.R., Could carnosine or related structures suppress Alzheimer's disease? (2007) J Alzheimer's Dis, 11, pp. 229-240
Hipkiss, A.R., On why decreasing protein synthesis can increase lifespan (2007) Mech Ageing Dev, 128, pp. 412-414
Baur, J.A., Sinclair, D.A., Therapeutic potential of resveratrol: The in vivo evidence (2006) Nat Rev Drug Discov, 5, pp. 493-506
Pallàs, M., Verdaguer, E., Tajes, M., Gutierrez-Cuesta, J., Camins, A., Modulation of sirtuins: New targets for antiageing (2008) Recent Patents CNS Drug Discov, 3, pp. 61-69
Milne, J.C., Lambert, P.D., Schenk, S., Carney, D.P., Smith, J.J., Gagne, D.J., Jin, L., Westphal, C.H., Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes (2007) Nature, 450, pp. 712-716
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Auwerx, J., Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha (2006) Cell, 127, pp. 1109-1122
Suzuki, K., Koike, T., Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: Activation of SIRT2, an NAD-dependent tubulin deacetylase (2007) Biochem Biophys Res Commun, 359, pp. 665-671
Outeiro, T.F., Kontopoulos, E., Altmann, S.M., Kufareva, I., Strathearn, K.E., Amore, A.M., Volk, C.B., Kazantsev, A.G., Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease (2007) Science, 317, pp. 461-462
Qin, W., Chachich, M., Lane, M., Roth, G., Bryant, M., De Cabo, R., Ottinger, M.A., Pasinetti, G.M., Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus) (2006) J Alzheimers Dis, 10, pp. 417-422
Mayer, M.P., Bukau, B., Molecular chaperones: The busy life of Hsp90 (1999) Curr Biol, 9, pp. 322-325
Deocaris, C.C., Kaul, S.C., Wadhwa, R., On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60 (2006) Cell Stress Chaperones, 11, pp. 116-128
Qiu, X.B., Shao, Y.M., Miao, S., Wang, L., The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones (2006) Cell Mol Life Sci, 63, pp. 2560-2570
James, M., Crabbe, C., Hepburne-Scott, H.W., Small heat shock proteins (sHSPs) as potential drug targets (2001) Curr Pharm Biotechnol, 2, pp. 77-111
Rahman, I., Biswas, S.K., Kirkham, P.A., Regulation of inflammation and redox signaling by dietary polyphenols (2006) Biochem Pharmacol, 72, pp. 1439-1452
Sharma, R.A., Gescher, A.J., Steward, W.P., Curcumin: The story so far (2005) Eur J Cancer, 41, pp. 1955-1968
Ravindranath, V., Chandrasekhara, N., Metabolism of curcumin-studies with [3H]curcumin (1981) Toxicology, 22, pp. 337-344
Maiti, K., Mukherjee, K., Gantait, A., Saha, B.P., Mukherjee, P.K., Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats (2007) Int J Pharm, 330, pp. 155-163
Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., Srinivas, P.S., Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers (1998) Planta Med, 64, pp. 353-356
Cheng, A.L., Hsu, C.H., Lin, J.K., Hsu, M.M., Ho, Y.F., Shen, T.S., Ko, J.Y., Hsieh, C.Y., Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions (2001) Anticancer Res, 21, pp. 2895-2900
Garcia-Alloza, M., Borrelli, L.A., Rozkalne, A., Hyman, B.T., Bacskai, B.J., Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model (2007) J Neurochem, 102, pp. 1095-1104
Somparn, P., Phisalaphong, C., Nakornchai, S., Unchern, S., Morales, N.P., Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives (2007) Biol Pharm Bull, 30, pp. 74-78
Ireson, C.R., Jones, D.J., Orr, S., Coughtrie, M.W., Boocock, D.J., Williams, M.L., Farmer, P.B., Gescher, A.J., Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine (2002) Cancer Epidemiol Biomarkers Prev, 11, pp. 105-111
Lin, J.K., Pan, M.H., Lin-Shiau, S.Y., Recent studies on the biofunctions and biotransformations of curcumin (2000) Biofactors, 13, pp. 153-158
Hayeshi, R., Mutingwende, I., Mavengere, W., Masiyanise, V., Mukanganyama, S., The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin (2007) Food Chem Toxicol, 45, pp. 286-295
Thapliyal, R., Maru, G.B., Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo (2001) Food Chem Toxicol, 39, pp. 541-547
Basu, N.K., Ciotti, M., Hwang, M.S., Kole, L., Mitra, P.S., Cho, J.W., Owens, I.S., Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake (2004) J Biol Chem, 279, pp. 1429-1441
Oetari, S., Sudibyo, M., Commandeur, J.N., Samhoedi, R., Vermeulen, N.P., Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver (1996) Biochem Pharmacol, 51, pp. 39-45
Deodhar, S.D., Sethi, R., Srimal, R.C., Preliminary study on antirheumatic activity of curcumin (diferuloyl methane) (1980) Indian J Med Res, 71, pp. 632-634
Sharma, R.A., Euden, S.A., Platton, S.L., Cooke, D.N., Shafayat, A., Hewitt, H.R., Marczylo, T.H., Steward, W.P., Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance (2004) Clin Cancer Res, 10, pp. 6847-6854
Sugiyama, Y., Kawakishi, S., Osawa, T., Involvement of the beta-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin (1996) Biochem Pharmacol, 52, pp. 519-525
Osawa, T., Sugiyama, Y., Inayoshi, M., Kawakishi, S., Antioxidative activity of tetrahydrocurcuminoids (1995) Biosci Biotechnol Biochem, 59, pp. 1609-1612
Chen, W.F., Deng, S.L., Zhou, B., Yang, L., Liu, Z.L., Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups (2006) Free Radic Biol Med, 40, pp. 526-535
Priyadarsini, K.I., Maity, D.K., Naik, G.H., Kumar, M.S., Unnikrishnan, M.K., Satav, J.G., Mohan, H., Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin (2003) Free Radic Biol Med, 35, pp. 475-484
Reyes-Gordillo, K., Segovia, J., Shibayama, M., Vergara, P., Moreno, M.G., Muriel, P., Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress (2007) Biochim Biophys Acta, 1770, pp. 989-996
Venkataranganna, M.V., Rafiq, M., Gopumadhavan, S., Peer, G., Babu, U.V., Mitra, S.K., NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NFkappa-B and iNOS (2007) World J Gastroenterol, 13, pp. 1103-1107
Shishodia, S., Potdar, P., Gairola, C.G., Aggarwal, B.B., Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: Correlation with suppression of COX-2, MMP-9 and cyclin D1 (2003) Carcinogenesis, 24, pp. 1269-1279
Bhattacharyya, S., Mandal, D., Sen, G.S., Pal, S., Banerjee, S., Lahiry, L., Finke, J.H., Sa, G., Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: Protection by curcumin (2007) Cancer Res, 67, pp. 362-370
Choi, H., Chun, Y.S., Kim, S.W., Kim, M.S., Park, J.W., Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: A mechanism of tumor growth inhibition (2006) Mol Pharmacol, 70, pp. 1664-1671
Abuarqoub, H., Green, C.J., Foresti, R., Motterlini, R., Curcumin reduces cold storage-induced damage in human cardiac myoblasts (2007) Exp Mol Med, 39, pp. 139-148
Jeong, G.S., Oh, G.S., Pae, H.O., Jeong, S.O., Kim, Y.C., Shin, M.K., Seo, B.Y., Chung, H.T., Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: Ortho-methoxy groups are essential to enhance heme oxygenase activity and protection (2006) Exp Mol Med, 38, pp. 393-400
McNally, S.J., Harrison, E.M., Ross, J.A., Garden, O.J., Wigmore, S.J., Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury (2006) Transplantation, 81, pp. 623-626
Rushworth, S.A., Ogborne, R.M., Charalambos, C.A., O'Connell, M.A., Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes (2006) Biochem Biophys Res Commun, 341, pp. 1007-1016
Balogun, E., Foresti, R., Green, C.J., Motterlini, R., Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells (2003) Biochem Biophys Res Commun, 308, pp. 950-955
Andreadi, C.K., Howells, L.M., Atherfold, P.A., Manson, M.M., Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols (2006) Mol Pharmacol, 69, pp. 1033-1040
Rashmi, R., Santhosh Kumar, T.R., Karunagaran, D., Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases (2003) FEBS Lett, 538, pp. 19-24
Sood, A., Mathew, R., Trachtman, H., Cytoprotective effect of curcumin in human proximal tubule epithelial cells exposed to shiga toxin (2001) Biochem Biophys Res Commun, 283, pp. 36-41
Chen, Y.C., Tsai, S.H., Shen, S.C., Lin, J.K., Lee, W.R., Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells (2001) Eur J Cell Biol, 80, pp. 213-221
Chen, Y.C., Kuo, T.C., Lin-Shiau, S.Y., Lin, J.K., Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells (1996) Mol Carcinog, 17, pp. 224-234
Kato, K., Ito, H., Kamei, K., Iwamoto, I., Stimulation of the stress-induced expression of stress proteins by curcumin in cultured cells and in rat tissues in vivo (1998) Cell Stress Chaperones, 3, pp. 152-160
Fang, J., Lu, J., Holmgren, A., Thioredoxin reductase is irreversibly modified by curcumin: A novel molecular mechanism for its anticancer activity (2005) J Biol Chem, 280, pp. 25284-25290
Moi, P., Chan, K., Asunis, I., Cao, A., Kan, Y.W., Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region (1994) Proc Natl Acad Sci USA, 91, pp. 9926-9930
Talalay, P., Chemoprotection against cancer by induction of phase 2 enzymes (2000) Biofactors, 12, pp. 5-11
Nguyen, T., Scherratt, P.J., Pickett, C.B., Regulatory mechanisms controlling gene expression mediated by the antioxidant response element (2003) Annu Rev Pharmacol Toxicol, 43, pp. 233-260
Nioi, P., McMahon, M., Itoh, K., Yamamoto, M., Hayes, J.D., Identification of a novel Nrf2-regulated antioxidant response element (2003) Biochem J, 374, pp. 337-348
Prestera, T., Talalay, P., Alam, J., Ahn, Y.I., Lee, P.J., Choi, A.M., Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE) (1995) Mol Med, 1, pp. 827-837
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J.D., Yamamoto, M., Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain (1999) Genes Dev, 13, pp. 76-86
Motohashi, H., Yamamoto, M., Nrf2-Keap1 defines a physiologically important stress response mechanism (2004) Trends Mol Med, 10, pp. 549-557
Katsuoka, F., Motohashi, H., Ishii, T., Aburatani, H., Engel, J.D., Yamamoto, M., Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes (2005) Mol Cell Biol, 25, pp. 8044-8051
Lee, J.M., Li, J., Johnson, D.A., Stein, T.D., Kraft, A.D., Calkins, M.J., Jakel, R.J., Johnson, J.A., Nrf2, a multi-organ protector? (2005) FASEB J, 19, pp. 1061-1066
Kensler, T.W., Wakabayashi, N., Biswal, S., Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway (2007) Annu Rev Pharmacol Toxicol, 47, pp. 89-116
McMahon, M., Thomas, N., Itoh, K., Yamamoto, M., Hayes, J.D., Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: A two-site interaction model for the Nrf2-Keap1 complex (2006) J Biol Chem, 281, pp. 24756-24768
Kobayashi, M., Yamamoto, M., Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species (2006) Adv Enzyme Regul, 46, pp. 113-140
Rangasamy, T., Cho, C.Y., Thimmulappa, R.K., Zhen, L., Srisuma, S.S., Kensler, T.W., Yamamoto, M., Biswal, S., Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice (2004) J Clin Invest, 114, pp. 1248-1259
Rangasamy, T., Guo, G., Mitzner, W.A., Roman, J., Singh, A., Fryer, A.D., Yamamoto, M., Biswal, S., Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice (2005) J Exp Med, 202, pp. 47-59
Thimmulappa, R.K., Lee, H., Rangasamy, T., Reddy, S.P., Yamamoto, M., Kensler, T.W., Biswal, S., Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis (2006) J Clin Invest, 116, pp. 984-995
Zhang, X., Lu, L., Dixon, C., Wilmer, W., Song, H., Chen, X., Rovin, B.H., Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12, 14-prostaglandin J2 in human mesangial cells (2004) Kidney Int, 65, pp. 798-810
Rokutan, K., Miyoshi, M., Teshima, S., Kawai, T., Kawahara, T., Kishi, K., Phenylarsine oxide inhibits heat shock protein 70 induction in cultured guinea pig gastric mucosal cells (2000) Am J Physiol Cell Physiol, 279, pp. 1506-1515
Liu, H., Lightfoot, R., Stevens, J.L., Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols (1996) J Biol Chem, 271, pp. 4805-4812
Tabner, B.J., Turnbull, S., El-Agnaf, O., Allsop, D., Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases (2001) Curr Top Med Chem, 1, pp. 507-517
Barnham, K.J., Cappai, R., Beyreuther, K., Masters, C.L., Hill, A.F., Delineating common molecular mechanisms in Alzheimer's and prion diseases (2006) Trends Biochem Sci, 31, pp. 465-472
Hinault, M., Ben-Zvi, A., Goloubinoff, P., Chaperones and proteases: Cellular fold-controlling factors of proteins in neurodegenerative diseases and aging (2006) J Mol Neurosci, 30, pp. 249-265
Nakamura, T., Lipton, S.A., Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases (2007) Cell Mol Life Sci, 64, pp. 1609-1620
Schroder, M., The unfolded protein response (2006) Mol Biotechnol, 34, pp. 279-290
Schroder, M., Kaufman, R.J., The mammalian unfolded protein response (2005) Annu Rev Biochem, 74, pp. 739-789
Calabrese, V., Sultana, R., Scapagnini, G., Guagliano, E., Sapienza, M., Bella, R., Kanski, J., Butterfield, D.A., Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease (2006) Antioxid Redox Signal, 8, pp. 1975-1986
Katzman, R., Saitoh, T., Advances in Alzheimer's disease (1991) FASEB J, 5, pp. 278-286
Guix, F.X., Uribesalgo, I., Coma, M., Muñoz, F.J., The physiology and pathophysiology of nitric oxide in the brain (2005) Prog Neurobiol, 76, pp. 126-152
Kim, D.S., Park, S.Y., Kim, J.K., Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult (2001) Neurosci Lett, 303, pp. 57-61
Ono, K., Hasegawa, K., Naiki, H., Yamada, M., Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro (2004) J Neurosci Res, 75, pp. 742-750
Yang, F., Lim, G.P., Begum, A.N., Ubeda, O.J., Simmons, M.R., Ambegaokar, S.S., Chen, P.P., Cole, G.M., Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo (2005) J Biol Chem, 280, pp. 5892-5901
Voelker, R., Parkinson disease guidelines aid diagnosis, management (2006) JAMA, 295, pp. 2126-2128
Przedborski, S., Ischiropoulos, H., Reactive oxygen and nitrogen species: Weapons of neuronal destruction in models of Parkinson's disease (2005) Antioxid Redox Signal, 7, pp. 685-693
Hald, A., Lotharius, J., Oxidative stress and inflammation in Parkinson's disease: Is there a causal link? (2005) Exp Neurol, 193, pp. 279-290
Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D.M., Kopin, I.J., A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (1983) Proc Natl Acad Sci USA, 80, pp. 4546-4550
Chiueh, C.C., Andoh, T., Lai, A.R., Lai, E., Krishna, G., Neuroprotective strategies in Parkinson's disease: Protection against progressive nigral damage induced by free radicals (2000) Neurotox Res, 2, pp. 293-310
Rajeswari, A., Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (2006) Eur Rev Med Pharmacol Sci, 10, pp. 157-161
Chen, J., Tang, X.P., Zhi, J.L., Cui, Y., Yu, H.M., Tang, E.H., Sun, S.N., Chen, P.X., Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway (2006) Apoptosis, 11, pp. 943-953
Mythri, R.B., Jagatha, B., Pradhan, N., Andersen, J., Bharath, M.M., Mitochondrial complex I inhibition in Parkinson's disease: How can curcumin protect mitochondria? (2007) Antioxid Redox Signal, 9, pp. 399-408
Dürr, A., Cossee, M., Agid, Y., Campuzano, V., Mignard, C., Penet, C., Mandel, J.L., Koenig, M., Clinical and genetic abnormalities in patients with Friedreich's ataxia (1996) N Engl J Med, 335, pp. 1169-1175
Campuzano, V., Montermini, L., Moltò, M.D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Pandolfo, M., Friedreich's ataxia: Autosomal recessive disease caused by an intronic GAA triplet repeat expansion (1996) Science, 271, pp. 1423-1427
Bidichandani, S.I., Ashizawa, T., Patel, P.I., The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure (1998) Am J Hum Genet, 62, pp. 111-1121
Lamarche, J.B., Lemieux, B., Lieu, H.B., The neuropathology of "typical" Friedreich's ataxia in Quebec (1984) Can J Neurol Sci, 11, pp. 592-600
Delatycki, M.B., Paris, D.B., Gardner, R.J., Nicholson, G.A., Nassif, N., Storey, E., MacMillan, J.C., Forrest, S.M., Clinical and genetic study of Friedreich ataxia in an Australian population (1999) Am J Med Genet, 87, pp. 168-174
Montermini, L., Richter, A., Morgan, K., Justice, C.M., Julien, D., Castellotti, B., Mercier, J., Pandolfo, M., Phenotypic variability in Friedreich ataxia: Role of the associated GAA triplet repeat expansion (1997) Ann Neurol, 41, pp. 675-678
Filla, A., De Michele, G., Cavalcanti, F., Pianese, L., Monticelli, A., Campanella, G., Cocozza, S., The relationship between trinucleotide (GAA) repeat length and clinical features in Friedreich ataxia (1996) Am J Hum Genet, 59, pp. 554-560
Sakamoto, N., Ohshima, K., Montermini, L., Pandolfo, M., Wells, R.D., Sticky DNA, a selfassociated complex formed at long GAA*TTC repeats in intron 1 of the frataxin gene, inhibits transcription (2001) J Biol Chem, 276, pp. 27171-27177
Krasilnikova, M.M., Mirkin, S.M., Replication stalling at Friedreich's ataxia (GAA)n repeats in vivo (2004) Mol Cell Biol, 24, pp. 2286-2295
Barski, A., Cuddapah, S., Cui, K., Roh, T.Y., Schones, D.E., Wang, Z., Wei, G., Zhao, K., High-resolution profiling of histone methylations in the human genome (2007) Cell, 129, pp. 823-837
Herman, D., Jenssen, K., Burnett, R., Soragni, E., Perlman, S.L., Gottesfeld, J.M., Histonedeacetylase inhibitors reverse gene silencing in Friedreich's ataxia (2006) Nat Chem Biol, 2, pp. 551-558
Greene, E., Mahishi, L., Entezam, A., Kumari, D., Usdin, K., Repeat-induced epigenetic changes in intron 1 of the frataxin gene and its consequences in Friedreich ataxia (2007) Nucleic Acids Res, 35, pp. 3383-3390
Al-Mahdawi, S., Pinto, R.M., Ismail, O., Varshney, D., Lymperi, S., Sandi, C., Trabzuni, D., Pook, M., The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues (2008) Hum Mol Genet, 17, pp. 735-746
Sarsero, J.P., Li, L., Wardan, H., Sitte, K., Williamson, R., Ioannou, P.A., Upregulation of expression from the FRDA genomic locus for the therapy of Friedreich ataxia (2003) J Gene Med, 5, pp. 72-81
Bradley, J.L., Blake, J.C., Chamberlain, S., Thomas, P.K., Cooper, J.M., Schapira, A.H., Clinical, biochemical and molecular genetic correlations in Friedreich's ataxia (2000) Hum Mol Genet, 9, pp. 275-282
Babcock, M., De Silva, D., Oaks, R., Davis-Kaplan, S., Jiralerspong, S., Montermini, L., Pandolfo, M., Kaplan regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin (1997) Science, 276, pp. 1709-1712
Foury, F., Cazzalini, O., Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria (1997) FEBS Lett, 411, pp. 373-377
Koutnikova, H., Campuzano, V., Foury, F., Dollé, P., Cazzalini, O., Koenig, M., Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin (1997) Nat Genet, 16, pp. 345-351
Rötig, A., De Lonlay, P., Chretien, D., Foury, F., Koenig, M., Sidi, D., Munnich, A., Rustin, P., Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia (1997) Nat Genet, 17, pp. 215-217
Foury, F., Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain (1999) FEBS Lett, 456, pp. 281-284
Bulteau, A.L., O'Neill, H.A., Kennedy, M.C., Ikeda-Saito, M., Isaya, G., Szweda, L.I., Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity (2004) Science, 305, pp. 242-245
Piemonte, F., Pastore, A., Tozzi, G., Tagliacozzi, D., Santorelli, F.M., Carrozzo, R., Casali, C., Bertini, E., Glutathione in blood of patients with Friedreich's ataxia (2001) Eur J Clin Invest, 31, pp. 1007-1011
Schulz, J.B., Dehmer, T., Schöls, L., Mende, H., Hardt, C., Vorgerd, M., Bürk, K., Bogdanov, M.B., Oxidative stress in patients with Friedreich ataxia (2000) Neurology, 55, pp. 1719-1721
Emond, M., Lepage, G., Vanasse, M., Pandolfo, M., Increased levels of plasma malondialdehyde in Friedreich ataxia (2000) Neurology, 55, pp. 1752-1753
Bradley, J.L., Homayoun, S., Hart, P.E., Schapira, A.H., Cooper, J.M., Role of oxidative damage in Friedreich's ataxia (2004) Neurochem Res, 29, pp. 561-567
Santos, M.M., Ohshima, K., Pandolfo, M., Frataxin deficiency enhances apoptosis in cells differentiating into neuroectoderm (2001) Hum Mol Genet, 10, pp. 1935-1944
Sturm, B., Stupphann, D., Kaun, C., Boesch, S., Schranzhofer, M., Wojta, J., Goldenberg, H., Scheiber-Mojdehkar, B., Recombinant human erythropoietin: Effects on frataxin expression in vitro (2005) Eur J Clin Invest, 35, pp. 711-717
Boesch, S., Sturm, B., Hering, S., Goldenberg, H., Poewe, W., Scheiber-Mojdehkar, B., Friedreich's ataxia: Clinical pilot trial with recombinant human erythropoietin (2007) Ann Neurol, 62, pp. 521-524
Lodi, R., Hart, P.E., Rajagopalan, B., Taylor, D.J., Crilley, J.G., Bradley, J.L., Blamire, A.M., Cooper, J.M., Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia (2001) Ann Neurol, 49, pp. 590-596
Hart, P.E., Lodi, R., Rajagopalan, B., Bradley, J.L., Crilley, J.G., Turner, C., Blamire, A.M., Cooper, J.M., Antioxidant treatment of patients with Friedreich ataxia: Four-year follow-up (2005) Arch Neurol, 62, pp. 621-626
Rustin, P., Von Kleist-Retzow, J.C., Chantrel-Groussard, K., Sidi, D., Munnich, A., Rötig, A., Effect of idebenone on cardiomyopathy in Friedreich's ataxia: A preliminary study (1999) Lancet, 354, pp. 477-479
Hausse, A.O., Aggoun, Y., Bonnet, D., Sidi, D., Munnich, A., Rötig, A., Rustin, P., Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia (2002) Heart, 87, pp. 346-349
Buyse, G., Mertens, L., Di Salvo, G., Matthijs, I., Weidemann, F., Eyskens, B., Goossens, W., Van Hove, J.L., Idebenone treatment in Friedreich's ataxia: Neurological, cardiac, and biochemical monitoring (2003) Neurology, 60, pp. 1679-1681
Mariotti, C., Solari, A., Torta, D., Marano, L., Fiorentini, C., Di Donato, S., Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial (2003) Neurology, 60, pp. 1676-1679
Di Prospero, N.A., Baker, A., Jeffries, N., Fischbeck, K.H., Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: A randomised, placebo-controlled trial (2007) Lancet Neurol, 6, pp. 878-886
Jauslin, M.L., Meier, T., Smith, R.A., Murphy, M.P., Mitochondria-targeted antioxidants protect Friedreich ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants (2003) FASEB J, 17, pp. 1972-1974
Al-Omar, F.A., Nagi, M.N., Abdulgadir, M.M., Al Joni, K.S., Al-Majed, A.A., Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus (2006) Neurochem Res, 31, pp. 611-618
Wang, Q., Sun, A.Y., Simonyi, A., Jensen, M.D., Shelat, P.B., Rottinghaus, G.E., MacDonald, R.S., Sun, G.Y., Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits (2005) J Neurosci Res, 82, pp. 138-148
Ghoneim, A.I., Abdel-Naim, A.B., Khalifa, A.E., El-Denshary, E.S., Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain (2002) Pharmacol Res, 46, pp. 273-279
Evans, A.M., Fornasini, G., Pharmacokinetics of L-carnitine (2003) Clin Pharmacokinet, 42, pp. 941-967
Rebouche, C.J., Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism (2004) Ann NY Acad Sci, 1033, pp. 30-41
Lombard, K.A., Olson, A.L., Nelson, S.E., Rebouche, C.J., Carnitine status of lactoovovegetarians and strict vegetarian adults and children (1989) Am J Clin Nutr, 50, pp. 301-306
Brass, E.P., Hoppel, C.L., Hiatt, W.R., Effect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans (1994) Clin Pharmacol Ther, 55, pp. 681-692
Gross, C.J., Savaiano, D.A., Effect of development and nutritional state on the uptake, metabolism and release of free and acetyl-L-carnitine by the rodent small intestine (1993) Biochim Biophys Acta, 1170, pp. 265-274
Parnetti, L., Gaiti, A., Mecocci, P., Cadini, D., Senin, U., Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type (1992) Eur J Clin Pharmacol, 42, pp. 89-93
Kelly, J.G., Hunt, S., Doyle, G.D., Laher, M.S., Carmody, M., Marzo, A., Arrigoni Martelli, E., Pharmacokinetics of oral acetyl-L-carnitine in renal impairment (1990) Eur J Clin Pharmacol, 38, pp. 309-312
McDaniel, M.A., Maier, S.F., Einstein, G.O., "brain-specific" nutrients: A memory cure? (2003) Nutrition, 19, pp. 957-975
Abdul, H.M., Calabrese, V., Calvani, M., Butterfield, D.A., Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease (2006) J Neurosci Res, 84, pp. 398-408
Calabrese, V., Colombrita, C., Sultana, R., Scapagnini, G., Calvani, M., Butterfield, D.A., Stella, A.M., Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: Relationship to antioxidant status and mitochondrial function (2006) Antioxid Redox Signal, 8, pp. 404-416
Rai, G., Wright, G., Scott, L., Beston, B., Rest, J., Exton-Smith, A.N., Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia (1990) Curr Med Res Opin, 11, pp. 638-647
Spagnoli, A., Lucca, U., Menasce, G., Bandera, L., Cizza, G., Forloni, G., Tettamanti, M., Comelli, M., Long-term acetyl-L-carnitine treatment in Alzheimer's disease (1991) Neurology, 41, pp. 1726-1732
Thal, L.J., Carta, A., Clarke, W.R., Ferris, S.H., Friedland, R.P., Petersen, R.C., Pettegrew, J.W., Woolson, R.F., A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease (1996) Neurology, 47, pp. 705-711
Thal, L.J., Calvani, M., Amato, A., Carta, A., A 1-year controlled trial of acetyl-l-carnitine in early-onset AD (2000) Neurology, 55, pp. 805-810
Calabrese, V., Ravagna, A., Colombrita, C., Guagliano, E., Scapagnini, G., Calvani, M., Butterfield, D.A., Giuffrida Stella, A.M., Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: Involvement of the transcription factor Nrf2 (2005) J Neurosci Res, 79, pp. 509-521
Snyder, S.H., Brain peptides as neurotransmitters (1980) Science, 209, pp. 976-983
Abe, H., Role of histidine-related compounds as intracellular proton buffering constituents in vertebrate muscle (2000) Biochemistry (Mosc), 65, pp. 757-765
Hipkiss, A.R., Preston, J.E., Himsworth, D.T., Worthington, V.C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N.J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann NY Acad Sci, 854, pp. 37-53
Bakardjiev, A., Biosynthesis of carnosine in primary cultures of rat olfactory bulb (1997) Neurosci Lett, 227, pp. 115-118
Teufel, M., Saudek, V., Ledig, J.P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase (2003) J Biol Chem, 278, pp. 6521-6531
Bauer, K., Barret, A.J., Rawlings, N.D., Woessner, J.F., X-His dipeptidase (2004) Handbook of Proteolytic Enzymes, pp. 1023-1024. , 2 Elsevier Amsterdam
De Marchis, S., Modena, C., Peretto, P., Giffard, C., Fasolo, A., Carnosine-like immunoreactivity in the central nervous system of rats during postnatal development (2000) J Comp Neurol, 426, pp. 378-390
Bauer, K., Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brain (2005) Neurochem Res, 30, pp. 1339-1345
McFarland, G.A., Holliday, R., Retardation of senescence in cultured human diploid fibroblasts by carnosine (1994) Exp Cell Res, 212, pp. 167-175
Yuneva, A.O., Kramarenko, G.G., Vetreshchak, T.V., Gallant, S., Boldyrev, A.A., Effect of carnosine on Drosophila melanogaster lifespan (2002) Bull Exp Biol Med, 133, pp. 559-561
Yuneva, A.O., Bulygina, E.R., Gallant, S., Kramarenko, G.G., Stvolinsky, S.L., Semyonova, M.L., Boldyrev, A.A., Effect of carnosine on age-induced changes in senescence-accelerated mice (1999) J Anti-Aging Med, 2, pp. 337-342
Babizhayev, M.A., Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care products (2006) Life Sci, 78, pp. 2343-2357
Lee, Y., Hsu, C., Lin, M., Liu, K., Yin, M., Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation (2005) Eur J Pharmacol, 512, pp. 145-150
Rashid, I., Van Reyk, D.M., Davies, M.J., Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro (2007) FEBS Letts, 581, pp. 1067-1070
Sauerhofer, S., Yuan, G., Braun, G.S., Deizer, M., Neumaier, M., Gretz, N., Floege, J., Moeller, M.J., L-Carnosine, a substrate of carnosinase-1, influences glucose metabolism (2007) Diabetes, 56, pp. 2425-2432
Hipkiss, A.R., Glycation, aging and carnosine: Are carnivorous diets beneficial? (2005) Mech Ageing Dev, 126, pp. 1034-1039
Huang, Y., Duan, J., Chen, H., Chen, M., Chen, G., Separation and determination of carnosine-related peptides using capillary electrophoresis with laser-induced fluorescence detection (2005) Electrophoresis, 26, pp. 593-599
Dobrota, D., Fedorova, T., Stvolinsky, S., Babusikova, E., Likavcanova, K., Drgova, A., Strapkova, A., Boldyrev, A., Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: After-stroke-effect (2005) Neurochem Res, 30, pp. 1283-1288
Stvolinsky, S., Kukley, M., Dobrota, D., Mezesova, V., Boldyrev, A., Carnosine protects rats under global ischemia (2000) Brain Res Bull, 53, pp. 445-448
Tang, S., Arumugam, T.V., Cutler, R.G., Jo, D., Magnus, T., Chan, S.L., Mughal, M.R., Mattson, M.P., (2007) J Neurochem, 101, pp. 729-736
Pubill, D., Verdaguer, E., Sureda, F.X., Camins, A., Pallas, M., Camarasa, J., Escubedo, E., Carnosine prevents methamphetamine-induced gliosis but not dopamine terminal loss in rats (2002) Eur J Pharmacol, 448, pp. 165-168
Dukic-Stefanovic, S., Schinzel, R., Riederer, P., Munch, G., AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs? (2001) Biogerontology, 2, pp. 19-34
Trombley, P.Q., Horning, M.S., Blakemore, L.J., Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmission (1998) Neuroreport, 9, pp. 3503-3507
Preston, J.E., Hipkiss, A.R., Himsworth, D.T., Romero, I.A., Abbott, J.N., Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine (1998) Neurosci Lett, 242, pp. 105-108
Fu, Q., Dai, H., Hu, W., Fan, Y., Zhang, Y., Chen, Z., Carnosine protects against Aβ-42-induced neurotoxicity in differentiated rat PC12 cells (2008) Cell Mol Neurobiol, 28, pp. 307-316
Shen, Y., Hu, W., Dai, H., Fu, Q., Wei, E., Luo, J., Chen, Z., Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H 1/H3 receptors (2007) Biochem Pharmacol, 73, pp. 709-717
Fonteh, A.N., Harrington, R.J., Tsai, A., Liao, P., Harrington, M.G., Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects (2007) Amino Acids, 32, pp. 213-224
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell Mol Life Sci, 59, pp. 546-551
Severina, I.S., Bussygina, O.G., Pyatakova, N.V., Carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 783-788
Nicoletti, V.G., Santoro, A.M., Grasso, G., Vagliasindi, L.I., Giuffrida, M.L., Cuppari, C., Spina Purrello, V., Rizzarelli, E., Carnosine interaction with nitric oxide and astroglial protection (2007) J Neurosci Res, 85, pp. 2239-2245
La Mendola, D., Sortino, S., Vecchio, G., Rizzarelli, E., Synthesis of new carnosine derivatives of β-cyclodextrin and their hydroxyl scavenger ability (2002) Helv Chim Acta, 85, pp. 1633-1643
Bonomo, R.P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (2003) J Chem Soc Dalton Trans, pp. 4406-4415
Mineo, P., Vitalini, D., La Mendola, D., Rizzarelli, E., Scamporrino, E., Vecchio, G., ESI-MS and spectroscopic investigations on 6A, 6D-di-(β-alanyl-L- histidine)-6A, 6D-dideoxy-β-cyclodextrin and 6A, 6C-di-(β-alanyl-L- histidine)-6A, 6C-dideoxy-β-cyclodextrin and their copper(II) complexes (2004) J Inorg Biochem, 98, pp. 254-265
Bellia, F., La Mendola, D., MacCarrone, G., Mineo, P., Vitalizi, D., Scamporrino, E., Sortino, S., Rizzarelli, E., Copper(II) complexes with β-cyclodextrin-homocarnosine conjugates and their antioxidant activity (2007) Inorg Chim Acta, 360, pp. 949-954
Amorini, A.M., Bellia, F., Di Pietro, V., Giardina, B., La Mendola, D., Lazzarino, G., Sortino, S., Vecchio, G., Synthesis and antioxidant activity of new homocarnosine β-cyclodextrin conjugates (2007) Eur J Med Chem, 42, pp. 910-920
Bellia, F., Amorini, A.M., La Mendola, D., Vecchio, G., Gavazzi, B., Giardina, B., Di Pietro, V., Rizzarelli, E., New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (2008) Eur J Med Chem, 43, pp. 373-380
Adlard, P.A., Bush, A.I., Metals and Alzheimer's disease (2006) J Alzheimer's Dis, 10, pp. 145-163
Chrouch, P.J., White, A.R., Bush, A.I., The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease (2007) FEBS J, 274, pp. 375-3783
Wenzel, E., Somoza, V., Metabolism and bioavailability of trans-resveratrol (2005) Mol Nutr Food Res, 49, pp. 472-481
Walle, T., Hsieh, F., Delegge, M.H., Oatis Jr., J.E., Walle, U.K., High absorption but very low bioavailability of oral resveratrol in humans (2004) Drug Metab Dispos, 32, pp. 1377-1382
Soleas, G.J., Angelini, M., Grass, L., Diamandis, E.P., Goldberg, D.M., Absorption of trans-resveratrol in rats (2001) Methods Enzymol, 335, pp. 145-154
Jannin, B., Menzel, M., Berlot, J.P., Delmas, D., Lançon, A., Latruffe, N., Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: Plasmatic protein binding and cell uptake (2004) Biochem Pharmacol, 68, pp. 1113-1118
Zhou, S., Koh, H.L., Gao, Y., Gong, Z.Y., Lee, E.J., Herbal bioactivation: The good, the bad and the ugly (2004) Life Sci, 74, pp. 935-968
Cao, Z., Li, Y., Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: Protection against oxidative and electrophilic injury (2004) Eur J Pharmacol, 489, pp. 39-48
Asensi, M., Medina, I., Ortega, A., Carretero, J., Baño, M.C., Obrador, E., Estrela, J.M., Inhibition of cancer growth by resveratrol is related to its low bioavailability (2002) Free Radic Biol Med, 33, pp. 387-398
Kim, Y.A., Kim, G.Y., Park, K.Y., Choi, Y.H., Resveratrol inhibits nitric oxide and prostaglandin E2 production by lipopolysaccharide-activated C6 microglia (2007) J Med Food, 10, pp. 218-224
Anekonda, T.S., Resveratrol-a boon for treating Alzheimer's disease? (2006) Brain Res Rev, 52, pp. 316-326
Jang, J.H., Surh, Y.J., Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death (2003) Free Radic Biol Med, 34, pp. 1100-1110
Bastianetto, S., Brouillette, J., Quirion, R., Neuroprotective effects of natural products: Interaction with intracellular kinases, amyloid peptides and a possible role for transthyretin (2007) Neurochem Res, 32, pp. 1720-1725
Marambaud, P., Zhao, H., Davies, P., Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides (2005) J Biol Chem, 280, pp. 37377-37382
Bastianetto, S., Zheng, W.H., Quirion, R., Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons (2000) Br J Pharmacol, 131, pp. 711-720
Sharma, M., Gupta, Y.K., Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats (2002) Life Sci, 71, pp. 2489-2498
Anekonda, T.S., Reddy, P.H., Neuronal protection by sirtuins in Alzheimer's disease (2006) J Neurochem, 96, pp. 305-313
Chen, C.Y., Jang, J.H., Li, M.H., Surh, Y.J., Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells (2005) Biochem Biophys Res Commun, 331, pp. 993-1000
Zhuang, H., Kim, Y.S., Koehler, R.C., Doré, S., Potential mechanism by which resveratrol, a red wine constituent, protects neurons (2003) Ann NY Acad Sci, 993, pp. 276-286
Takahashi, M., Doré, S., Ferris, C.D., Tomita, T., Sawa, A., Wolosker, H., Borchelt, D.R., Snyder, S.H., Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease (2000) Neuron, 28, pp. 461-473
Halliwell, B., Biochemistry of oxidative stress (2007) Biochem Soc Trans, 35, pp. 1147-1150
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D.A., Giuffrida Stella, A.M., Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity (2007) Nat Rev Neurosci, 8, pp. 766-775
Hagen, T.M., Liu, J., Lykkesfeldt, J., Wehr, C.M., Ingersoll, R.T., Vinarsky, V., Bartholomew, J.C., Ames, B.N., Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress (2002) Proc Natl Acad Sci USA, 99, pp. 1870-1875
Hagen, T.M., Moreau, R., Suh, J.H., Visioli, F., Mitochondrial decay in the aging rat heart: Evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid (2002) Ann NY Acad Sci, 959, pp. 491-507
Liu, J., Head, E., Gharib, A.M., Yuan, W., Ingersoll, R.T., Hagen, T.M., Cotman, C.W., Ames, B.N., Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid (2002) Proc Natl Acad Sci USA, 99, pp. 2356-2361
Atamna, H., Nguyen, A., Schultz, C., Boyle, K., Newberry, J., Kato, H., Ames, B.N., Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways (2008) FASEB J, 22, pp. 703-712
Milgram, N.W., Araujo, J.A., Hagen, T.M., Treadwell, B.V., Ames, B.N., Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests (2007) FASEB J, 21, pp. 3756-3762
Calabrese, E., Hormesis: Why it is important to toxicology and toxicologists (2008) Environ Toxicol Chem, 14, p. 1
Calabrese, E.J., Another california milestone: The first application of hormesis in litigation and regulation (2008) Int J Toxicol, 27, pp. 31-33
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T, Review,
Impact factor: 2.26, 5-year impact factor: 2.312
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-56449129616&partnerID=40&md5=562023959b9b30042cb52deb8fad5fa6
Keywords: Aging, Antioxidants, Cellular Stress Response, Neurodegenerative Disorders, Redox Homeostasis, Vitagenes, Carnitine, Carnosine, Curcumin, Heat Shock Protein 10, Heme Oxygenase 1, Immunoglobulin Enhancer Binding Protein, Levacecarnine, Messenger Rna, Reactive Oxygen Metabolite, Resveratrol, Sirtuin, Thioredoxin, Thioredoxin Reductase, Alzheimer Disease, Caloric Intake, Cell Survival, Chemoprophylaxis, Diet Restriction, Disorders Of Mitochondrial Functions, Friedreich Ataxia, Gene Mutation, Genetic Code, Human, Longevity, Nerve Degeneration, Neuroprotection, Nonhuman, Nutritional Assessment, Oxidative Stress, Parkinson Disease, Priority Journal, Protein Folding, Review, Animals, Neurodegenerative Diseases, Reactive Oxygen Species,
Affiliations:
*** IBB - CNR ***
Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Viale Andrea Doria 6, 95100, Catania, Italy. calabres@unict.it
Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
Department of Neurosciences, University of Catania, Catania, Italy
University Department of Clinical Neurosciences, Institute of Neurology, University College London, Rowland Hill Street, London NW3 2PF, United Kingdom
School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom
Division of Clinical Pharmacology, Departments of Medicine and Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
Biomedical Research Centre, University of Dundee, United Kingdom
References:
Halliwell, B., Oxidative stress and cancer: Have we moved forward? (2007) Biochem J, 401, pp. 1-1
Calabrese, V., Scapagnini, G., Colombrita, C., Ravagna, A., Pennisi, G., Giuffrida Stella, A.M., Galli, F., Butterfield, D.A., Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: A nutritional approach (2003) Amino Acids, 25, pp. 437-444
Poon, H.F., Calabrese, V., Scapagnini, G., Butterfield, D.A., Free radicals: Key to brain aging and heme oxygenase as a cellular response to oxidative stress (2004) J Gerontology, 59, pp. 478-493
Forman, H.J., Fukuto, J.M., Torres, M., Redox signaling: Thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers (2004) Am J Physiol Cell Physiol, 287, pp. 246-256
Calabrese, V., Giuffrida Stella, A.M., Butterfield, D.A., Scapagnini, G., Redox regulation in neurodegeneration and longevity: Role of the heme oxygenase and HSP70 systems in brain stress tolerance (2004) Antioxid Redox Signal, 6, pp. 895-913
Halliwell, B., Hypothesis: Proteasomal dysfunction: A primary event in neurogeneration that leads to nitrative and oxidative stress and subsequent cell death (2002) Ann NY Acad Sci, 962, pp. 182-194
Martindale, J.L., Holbrook, N.J., Cellular response to oxidative stress: Signaling for suicide and survival (2002) J Cell Physiol, 192, pp. 1-15
Bergamini, C.M., Gambetti, S., Dondi, A., Cervellati, C., Oxygen, reactive oxygen species and tissue damage (2004) Curr Pharm des, 10, pp. 1611-1626
Pappolla, M.A., Chyan, Y.J., Omar, R.A., Hsiao, K., Perry, G., Smith, M.A., Bozner, P., Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo (1998) Am J Pathol, 152, pp. 871-877
Smith, M.A., Hirai, K., Hsiao, K., Pappolla, M.A., Harris, P.L., Siedlak, S.L., Tabaton, M., Perry, G., Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress (1998) J Neurochem, 70, pp. 2212-2215
Butterfield, D.A., Drake, J., Pocernich, C., Castegna, A., Evidence of oxidative damage in Alzheimer's disease brain: Central role for amyloid beta-peptide (2001) Trends Mol Med, 7, pp. 548-554
Mattson, M.P., Pathways towards and away from Alzheimer's disease (2004) Nature, 430, pp. 631-639
Drew, B., Leeuwenburgh, C., Aging and the role of reactive nitrogen species (2002) Ann NY Acad Sci, 959, pp. 66-81
Kroncke, K.D., Nitrosative stress and transcription (2003) Biol Chem, 384, pp. 1365-1377
Ridnour, L.A., Thomas, D.D., Mancardi, D., Espey, M.G., Miranda, K.M., Paolocci, N., Feelisch, M., Wink, D.A., The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations (2004) Biol Chem, 385, pp. 1-10
Calabrese, V., Guagliano, E., Sapienza, M., Panebianco, M., Calafato, S., Puleo, E., Pennisi, G., Stella, A.G., Redox regulation of cellular stress response in aging and neurodegenerative disorders: Role of vitagenes (2007) Neurochem Res, 32, pp. 757-773
Calabrese, V., Boyd-Kimball, D., Scapagnini, G., Butterfield, D.A., Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: The role of vitagenes (2004) In Vivo, 18, pp. 245-267
Mancuso, C., Scapagnini, G., Curro, D., Giuffrida Stella, A.M., De Marco, C., Butterfield, D.A., Calabrese, V., Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders (2007) Front Biosci, 12, pp. 1107-1123
Vina, J., Borras, C., Gomez-Cabrera, M.C., Orr, W.C., Part of the series: From dietary antioxidants to regulators in cellular signalling and gene expression. Role of reactive oxygen species and (phyto)oestrogens in the modulation of adaptive response to stress (2006) Free Radic Res, 40, pp. 111-119
McCord, J.M., Fridovich, I., Superoxide dismutase: The first twenty years (1968-1988) (1988) Free Radic Biol Med, 5, pp. 363-369
Calabrese, E.J., Staudenmayer, J.W., Stanek, E.J., Drug development and hormesis: Changing conceptual understanding of the dose response creates new challenges and opportunities for more effective drugs (2006) Curr Opin Drug Discov Devel, 9, pp. 117-123
Zhang, K., Kaufman, R.J., The unfolded protein response: A stress signaling pathway critical for health and disease (2006) Neurology, 66, pp. 102-109
Calabrese, V., Butterfield, D.A., Scapagnini, G., Stella, A.M., Maines, M.D., Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: Relevance to brain aging, neurodegenerative disorders, and longevity (2006) Antioxid Redox Signal, 8, pp. 444-477
Maines, M.D., The heme oxygenase system: A regulator of second messenger gases (1997) Annu Rev Pharmacol Toxicol, 37, pp. 517-554
Mancuso, C., Heme oxygenase and its products in the nervous system (2004) Antioxid Redox Signal, 6, pp. 878-887
Stocker, R., Antioxidant activities of bile pigments (2004) Antioxid Redox Signal, 6, pp. 841-849
Mancuso, C., Pani, G., Calabrese, V., Bilirubin: An endogenous scavenger of nitric oxide and reactive nitrogen species (2006) Redox Rep, 11, pp. 207-213
Mancuso, C., Bonsignore, A., Capone, C., Di Stasio, E., Pani, G., Albumin-bound bilirubin interacts with nitric oxide by a redox mechanism (2006) Antioxid Redox Signal, 8, pp. 487-494
Simonian, N.A., Coyle, J.T., Oxidative stress in neurodegenerative diseases (1996) Annu Rev Pharmacol Toxicol, 36, pp. 83-106
Sayre, L.M., Smith, M.A., Perry, G., Chemistry and biochemistry of oxidative stress in neurodegenerative disease (2001) Curr Med Chem, 8, pp. 721-738
Andersen, J.K., Oxidative stress in neurodegeneration: Cause or consequence? (2004) Nat Med, 10, pp. 18-25
Mancuso, C., Perluigi, M., Cini, C., De Marco, C., Giuffrida Stella, A.M., Calabrese, V., Heme oxygenase and cyclooxygenase in the central nervous system: A functional interplay (2006) J Neurosci Res, 84, pp. 1385-1391
Panahian, N., Yoshiura, M., Maines, M.D., Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice (1999) J Neurochem, 72, pp. 1187-1203
Takeda, A., Perry, G., Abraham, N.G., Dwyer, B.E., Kutty, R.K., Laitinen, J.T., Petersen, R.B., Smith, M.A., Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau (2000) J Biol Chem, 275, pp. 5395-5399
Premkumar, D.R., Smith, M.A., Richey, P.L., Petersen, R.B., Castellani, R., Kutty, R.K., Wiggert, B., Kalaria, R.N., Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease (1995) J Neurochem, 65, pp. 1399-1402
Schipper, H.M., Heme oxygenase-1: Role in brain aging and neurodegeneration (2000) Exp Gerontol, 35, pp. 821-830
Mancuso, C., Bates, T.E., Butterfield, D.A., Calafato, S., Cornelius, C., De Lorenzo, A., Dinkova Kostova, A.T., Calabrese, V., Natural antioxidants in Alzheimer's disease (2007) Expert Opin Investig Drugs, 16, pp. 1921-1931
Butterfield, D., Castegna, A., Pocernich, C., Drake, J., Scapagnini, G., Calabrese, V., Nutritional approaches to combat oxidative stress in Alzheimer's disease (2002) J Nutr Biochem, 13, pp. 444-461
Ganguli, M., Chandra, V., Kamboh, M.I., Johnston, J.M., Dodge, H.H., Thelma, B.K., Juyal, R.C., Dekosky, S.T., Apolipoprotein e polymorphism and Alzheimer disease: The Indo-US Cross-National Dementia Study (2000) Arch Neurol, 57, pp. 824-830
Lim, G.P., Chu, T., Yang, F., Beech, W., Frautschy, S.A., Cole, G.M., The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse (2001) J Neurosci, 21, pp. 8370-8377
Wu, L., Wang, R., Carbon monoxide: Endogenous production, physiological functions, and pharmacological applications (2005) Pharmacol Rev, 57, pp. 585-630
Kostoglou-Athanassiou, I., Forsling, M.L., Navarra, P., Grossman, A.B., Oxytocin release is inhibited by the generation of carbon monoxide from the rat hypothalamus-further evidence for carbon monoxide as a neuromodulator (1996) Brain Res Mol Brain Res, 42, pp. 301-306
Mancuso, C., Kostoglou-Athanassiou, I., Forsling, M.L., Grossman, A.B., Preziosi, P., Navarra, P., Minotti, G., Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants, molecular linkage between heme catabolism and neuroendocrine function (1997) Brain Res Mol Brain Res, 50, pp. 267-276
Mancuso, C., Ragazzoni, E., Tringali, G., Liberale, I., Preziosi, P., Grossman, A., Navarra, P., Inhibition of heme oxygenase in the central nervous system potentiates endotoxin-induced vasopressin release in the rat (1999) J Neuroimmunol, 99, pp. 189-194
Parkes, D., Kasckow, J., Vale, W., Carbon monoxide modulates secretion of corticotropin-releasing factor from rat hypothalamic cell cultures (1994) Brain Res, 646, pp. 315-318
Pozzoli, G., Mancuso, C., Mirtella, A., Preziosi, P., Grossman, A.B., Navarra, P., Carbon monoxide as a novel neuroendocrine modulator: Inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants (1994) Endocrinology, 135, pp. 2314-2317
Mancuso, C., Pistritto, G., Tringali, G., Grossman, A.B., Preziosi, P., Navarra, P., Evidence that carbon monoxide stimulates prostaglandin endoperoxide synthase activity in rat hypothalamic explants and in primary cultures of rat hypothalamic astrocytes (1997) Brain Res Mol Brain Res, 45, pp. 294-300
Mancuso, C., Tringali, G., Grossman, A., Preziosi, P., Navarra, P., The generation of nitric oxide and carbon monoxide produces opposite effects on the release of immunoreactive interleukin-1beta from the rat hypothalamus in vitro: Evidence for the involvement of different signaling pathways (1998) Endocrinology, 139, pp. 1031-1037
Jaggar, J.H., Leffler, C.W., Cheranov, S.Y., Tcheranova, D., Shuyu, E., Cheng, X., Carbon monoxide dilates cerebral arterioles by enhancing the coupling of Ca2+ sparks to Ca2+-activated K+ channels (2002) Circ Res, 91, pp. 610-617
Otterbein, L.E., Bach, F.H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R.J., Choi, A.M., Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway (2000) Nat Med, 6, pp. 422-428
Ryter, S.W., Otterbein, L.E., Morse, D., Choi, A.M., Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance (2002) Mol Cell Biochem, 234-235, pp. 249-263
Yenari, M.A., Giffard, R.G., Sapolsky, R.M., Steinberg, G.K., The neuroprotective potential of heat shock protein 70 (HSP70) (1999) Mol Med Today, 5, pp. 525-531
Kelly, S., Zhang, Z.J., Zhao, H., Xu, L., Giffard, R.G., Sapolsky, R.M., Yenari, M.A., Steinberg, G.K., Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: Influence of Bcl-2 (2002) Ann Neurol, 52, pp. 160-167
Narasimhan, P., Swanson, R.A., Sagar, S.M., Sharp, F.R., Astrocyte survival and HSP70 heat shock protein induction following heatshock and acidosis (1996) Glia, 17, pp. 147-159
Fink, S.L., Chang, L.K., Ho, D.Y., Sapolsky, R.M., Defective herpes simplex virus vectors expressing the rat brain stress-inducible heat shock protein 72 protect cultured neurons from severe heat shock (1997) J Neurochem, 68, pp. 961-969
Hata, R., Maeda, K., Hermann, D., Mies, G., Hossmann, K.A., Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice (2000) J Cereb Blood Flow Metab, 20, pp. 306-315
Perez, N., Sugar, J., Charya, S., Johnson, G., Merril, C., Bierer, L., Perl, D., Wallace, W., Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease (1991) Brain Res Mol Brain Res, 11, pp. 249-254
Yoo, B.C., Seidl, R., Cairns, N., Lubec, G., Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease (1999) J Neural Transm Suppl, 57, pp. 315-322
Morrison-Bogorad, M., Zimmerman, A.L., Pardue, S., Heat-shock 70 messenger RNA levels in human brain: Correlation with agonal fever (1995) J Neurochem, 64, pp. 235-246
Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Shimohama, S., Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins (2002) FASEB J, 16, pp. 601-603
Calabrese, V., Testa, G., Ravagna, A., Bates, T.E., Stella, A.M., HSP70 induction in the brain following ethanol administration in the rat: Regulation by glutathione redox state (2000) Biochem Biophys Res Commun, 269, pp. 397-400
Calabrese, V., Bates, T.E., Giuffrida Stella, A.M., NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: The role of oxidant/antioxidant balance (2000) Neurochem Res, 65, pp. 1315-1341
Yamawaki, H., Haendeler, J., Berk, B.C., Thioredoxin: A key regulator of cardiovascular homeostasis (2003) Circ Res, 93, pp. 1029-1033
Cho, C.G., Kim, H.J., Chung, S.W., Jung, K.J., Shim, K.H., Yu, B.P., Yodoi, J., Chung, H.Y., Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process (2003) Exp Gerontol, 38, pp. 539-548
Arner, E.S., Holmgren, A., Physiological functions of thioredoxin and thioredoxin reductase (2000) Eur J Biochem, 267, pp. 6102-6109
Sun, Q.A., Kirnarsky, L., Sherman, S., Gladyshev, V.N., Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems (2001) Proc Natl Acad Sci USA, 98, pp. 3673-3678
Bloomfield, K.L., Osborne, S.A., Kennedy, D.D., Clarke, F.M., Tonissen, K.F., Thioredoxin-mediated redox control of the transcription factor Sp1 and regulation of the thioredoxin gene promoter (2003) Gene, 319, pp. 107-116
Kim, Y.C., Yamaguchi, Y., Kondo, N., Masutani, H., Yodoi, J., Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response (2003) Oncogene, 22, pp. 1860-1865
Tanito, M., Masutani, H., Kim, Y.C., Nishikawa, M., Ohira, A., Yodoi, J., Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice (2005) Invest Ophthalmol Vis Sci Mar, 46, pp. 979-987
Eftekharpour, E., Holmgren, A., Juurlink, B.H., Thioredoxin reductase and glutathione synthesis is upregulated by t-butylhydroquinone in cortical astrocytes but not in cortical neurons (2000) Glia, 31, pp. 241-248
Hintze, K.J., Wald, K.A., Zeng, H., Jeffery, E.H., Finley, J.W., Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element (2003) J Nutr, 133, pp. 2721-2727
Dinkova-Kostova, A.T., Cheah, J., Samouilov, A., Zweier, J.L., Bozak, R.E., Hicks, R.J., Talalay, P., Phenolic Michael reaction acceptors: Combined direct and indirect antioxidant defenses against electrophiles and oxidants (2007) Med Chem, 3, pp. 261-268
Sakurai, A., Nishimoto, M., Himeno, S., Imura, N., Tsujimoto, M., Kunimoto, M., Hara, S., Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: Role of NF-E2-related factor-2 (2005) J Cell Physiol, 203, pp. 529-537
Hirota, K., Nakamura, H., Masutani, H., Yodoi, J., Thioredoxin superfamily and thioredoxin-inducing agents (2002) Ann NY Acad Sci, 957, pp. 189-199
Baker, A.F., Dragovich, T., Tate, W.R., Ramanathan, R.K., Roe, D., Hsu, C.H., Kirkpatrick, D.L., Powis, G., The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma (2006) J Lab Clin Med, 147, pp. 83-90
Nakamura, H., Bai, J., Nishinaka, Y., Ueda, S., Sasada, T., Ohshio, G., Imamura, M., Yodoi, J., Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer (2000) Cancer Detect Prev, 24, pp. 53-60
Haapasalo, H., Kylaniemi, M., Paunul, N., Kinnula, V.L., Soini, Y., Expression of antioxidant enzymes in astrocytic brain tumors (2003) Brain Pathol, 13, pp. 155-164
Berggren, M.M., Powis, G., Alternative splicing is associated with decreased expression of the redox proto-oncogene thioredoxin-1 in human cancers (2001) Arch Biochem Biophys, 389, pp. 144-149
Biaglow, J.E., Miller, R.A., The thioredoxin reductase/thioredoxin system: Novel redox targets for cancer therapy (2005) Cancer Biol Ther, 4, pp. 6-13
Bai, J., Nakamura, H., Kwon, Y.W., Hattori, I., Yamaguchi, Y., Kim, Y.C., Kondo, N., Yodoi, J., Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells (2003) J Neurosci, 23, pp. 503-509
Masutani, H., Bai, J., Kim, Y.C., Yodoi, J., Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection (2004) Mol Neurobiol, 29, pp. 229-242
Trigona, W.L., Mullarky, I.K., Cao, Y., Sordillo, L.M., Thioredoxin reductase regulates the induction of heme oxygenase-1 expression in aortic endothelial cells (2006) Biochem J, 394, pp. 207-216
Satoh, T., Ishige, K., Sagara, Y., Protective effects on neuronal cells of mouse afforded by ebselen against oxidative stress at multiple steps (2004) Neurosci Lett, 371, pp. 1-5
Das, K.C., Das, C.K., Thioredoxin, a singlet oxygen quencher and hydroxyl radical scavenger: Redox independent functions (2000) Biochem Biophys Res Commun, 277, pp. 443-447
Ju, T.C., Chen, S.D., Liu, C.C., Yang, D.I., Protective effects of S-nitrosoglutathione against amyloid beta-peptide neurotoxicity (2005) Free Radic Biol Med, 38, pp. 938-949
Rauhala, P., Andoh, T., Yeh, K., Chiueh, C.C., Contradictory effects of sodium nitroprusside and S-nitroso-N- acetylpenicillamine on oxidative stress in brain dopamine neurons in vivo (2002) Ann NY Acad Sci, 962, pp. 60-72
Lee, S.Y., Andoh, T., Murphy, D.L., Chiueh, C.C., 17beta-estradiol activates ICI 182, 780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection (2003) FASEB J, 17, pp. 947-948
Westphal, C.H., Dipp, M.A., Guarente, L., A therapeutic role for sirtuins in diseases of aging? (2007) Trends Biochem Sci, 32, pp. 555-560
Salminen, A., Ojala, J., Huuskonen, J., Kauppinen, A., Suuronen, T., Kaarniranta, K., Interaction of aging-associated signaling cascades: Inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1 (2008) Cell Mol Life Sci, 65, pp. 1049-1058
Dali-Youcef, N., Lagouge, M., Froelich, S., Koehl, C., Schoonjans, K., Auwerx, J., Sirtuins: The 'magnificent seven', function, metabolism and longevity (2007) Ann Med, 39, pp. 335-345
Martin, B., Mattson, M.P., Maudsley, S., Caloric restriction and intermittent fasting: Two potential diets for successful brain aging (2006) Ageing Res Rev, 5, pp. 332-353
Mattson, M.P., Hormesis defined (2008) Ageing Res Rev, 7, pp. 1-7
Giannakou, M.E., Goss, M., Jacobson, J., Vinti, G., Leevers, S.J., Partridge, L., Dynamics of the action of dFOXO on adult mortality in Drosophila (2007) Aging Cell, 6, pp. 429-438
Guarente, L., Picard, F., Calorie restriction-SIR2 connection (2005) Cell, 120, pp. 473-482
Rodgers, J.T., Lerin, C., Haas, W., Cygi, S.P., Spiegelman, B.M., Puigserver, P., Nutrient control of glucose homeostasis through a complex of PGC-1and SIRT1 (2005) Nature, 434, pp. 113-118
Wang, F., Nguyen, M., Qin, F.X., Tong, Q., SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction (2007) Aging Cell, 6, pp. 505-514
Yang, T., Sauve, A.A., NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity (2006) AAPS J, 8, pp. 632-643
Smith, J., Human Sir2 and the 'silencing' of p53 activity (2002) Trends Cell Biol, 12, pp. 404-406
Hipkiss, A.R., Energy metabolism, altered proteins, sirtuins and ageing: Converging mechanisms? (2008) Biogerontology, 9, pp. 49-55
Hipkiss, A.R., Could carnosine or related structures suppress Alzheimer's disease? (2007) J Alzheimer's Dis, 11, pp. 229-240
Hipkiss, A.R., On why decreasing protein synthesis can increase lifespan (2007) Mech Ageing Dev, 128, pp. 412-414
Baur, J.A., Sinclair, D.A., Therapeutic potential of resveratrol: The in vivo evidence (2006) Nat Rev Drug Discov, 5, pp. 493-506
Pallàs, M., Verdaguer, E., Tajes, M., Gutierrez-Cuesta, J., Camins, A., Modulation of sirtuins: New targets for antiageing (2008) Recent Patents CNS Drug Discov, 3, pp. 61-69
Milne, J.C., Lambert, P.D., Schenk, S., Carney, D.P., Smith, J.J., Gagne, D.J., Jin, L., Westphal, C.H., Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes (2007) Nature, 450, pp. 712-716
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Auwerx, J., Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha (2006) Cell, 127, pp. 1109-1122
Suzuki, K., Koike, T., Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: Activation of SIRT2, an NAD-dependent tubulin deacetylase (2007) Biochem Biophys Res Commun, 359, pp. 665-671
Outeiro, T.F., Kontopoulos, E., Altmann, S.M., Kufareva, I., Strathearn, K.E., Amore, A.M., Volk, C.B., Kazantsev, A.G., Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease (2007) Science, 317, pp. 461-462
Qin, W., Chachich, M., Lane, M., Roth, G., Bryant, M., De Cabo, R., Ottinger, M.A., Pasinetti, G.M., Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus) (2006) J Alzheimers Dis, 10, pp. 417-422
Mayer, M.P., Bukau, B., Molecular chaperones: The busy life of Hsp90 (1999) Curr Biol, 9, pp. 322-325
Deocaris, C.C., Kaul, S.C., Wadhwa, R., On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60 (2006) Cell Stress Chaperones, 11, pp. 116-128
Qiu, X.B., Shao, Y.M., Miao, S., Wang, L., The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones (2006) Cell Mol Life Sci, 63, pp. 2560-2570
James, M., Crabbe, C., Hepburne-Scott, H.W., Small heat shock proteins (sHSPs) as potential drug targets (2001) Curr Pharm Biotechnol, 2, pp. 77-111
Rahman, I., Biswas, S.K., Kirkham, P.A., Regulation of inflammation and redox signaling by dietary polyphenols (2006) Biochem Pharmacol, 72, pp. 1439-1452
Sharma, R.A., Gescher, A.J., Steward, W.P., Curcumin: The story so far (2005) Eur J Cancer, 41, pp. 1955-1968
Ravindranath, V., Chandrasekhara, N., Metabolism of curcumin-studies with [3H]curcumin (1981) Toxicology, 22, pp. 337-344
Maiti, K., Mukherjee, K., Gantait, A., Saha, B.P., Mukherjee, P.K., Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats (2007) Int J Pharm, 330, pp. 155-163
Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., Srinivas, P.S., Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers (1998) Planta Med, 64, pp. 353-356
Cheng, A.L., Hsu, C.H., Lin, J.K., Hsu, M.M., Ho, Y.F., Shen, T.S., Ko, J.Y., Hsieh, C.Y., Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions (2001) Anticancer Res, 21, pp. 2895-2900
Garcia-Alloza, M., Borrelli, L.A., Rozkalne, A., Hyman, B.T., Bacskai, B.J., Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model (2007) J Neurochem, 102, pp. 1095-1104
Somparn, P., Phisalaphong, C., Nakornchai, S., Unchern, S., Morales, N.P., Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives (2007) Biol Pharm Bull, 30, pp. 74-78
Ireson, C.R., Jones, D.J., Orr, S., Coughtrie, M.W., Boocock, D.J., Williams, M.L., Farmer, P.B., Gescher, A.J., Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine (2002) Cancer Epidemiol Biomarkers Prev, 11, pp. 105-111
Lin, J.K., Pan, M.H., Lin-Shiau, S.Y., Recent studies on the biofunctions and biotransformations of curcumin (2000) Biofactors, 13, pp. 153-158
Hayeshi, R., Mutingwende, I., Mavengere, W., Masiyanise, V., Mukanganyama, S., The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin (2007) Food Chem Toxicol, 45, pp. 286-295
Thapliyal, R., Maru, G.B., Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo (2001) Food Chem Toxicol, 39, pp. 541-547
Basu, N.K., Ciotti, M., Hwang, M.S., Kole, L., Mitra, P.S., Cho, J.W., Owens, I.S., Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake (2004) J Biol Chem, 279, pp. 1429-1441
Oetari, S., Sudibyo, M., Commandeur, J.N., Samhoedi, R., Vermeulen, N.P., Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver (1996) Biochem Pharmacol, 51, pp. 39-45
Deodhar, S.D., Sethi, R., Srimal, R.C., Preliminary study on antirheumatic activity of curcumin (diferuloyl methane) (1980) Indian J Med Res, 71, pp. 632-634
Sharma, R.A., Euden, S.A., Platton, S.L., Cooke, D.N., Shafayat, A., Hewitt, H.R., Marczylo, T.H., Steward, W.P., Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance (2004) Clin Cancer Res, 10, pp. 6847-6854
Sugiyama, Y., Kawakishi, S., Osawa, T., Involvement of the beta-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin (1996) Biochem Pharmacol, 52, pp. 519-525
Osawa, T., Sugiyama, Y., Inayoshi, M., Kawakishi, S., Antioxidative activity of tetrahydrocurcuminoids (1995) Biosci Biotechnol Biochem, 59, pp. 1609-1612
Chen, W.F., Deng, S.L., Zhou, B., Yang, L., Liu, Z.L., Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups (2006) Free Radic Biol Med, 40, pp. 526-535
Priyadarsini, K.I., Maity, D.K., Naik, G.H., Kumar, M.S., Unnikrishnan, M.K., Satav, J.G., Mohan, H., Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin (2003) Free Radic Biol Med, 35, pp. 475-484
Reyes-Gordillo, K., Segovia, J., Shibayama, M., Vergara, P., Moreno, M.G., Muriel, P., Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress (2007) Biochim Biophys Acta, 1770, pp. 989-996
Venkataranganna, M.V., Rafiq, M., Gopumadhavan, S., Peer, G., Babu, U.V., Mitra, S.K., NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NFkappa-B and iNOS (2007) World J Gastroenterol, 13, pp. 1103-1107
Shishodia, S., Potdar, P., Gairola, C.G., Aggarwal, B.B., Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: Correlation with suppression of COX-2, MMP-9 and cyclin D1 (2003) Carcinogenesis, 24, pp. 1269-1279
Bhattacharyya, S., Mandal, D., Sen, G.S., Pal, S., Banerjee, S., Lahiry, L., Finke, J.H., Sa, G., Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: Protection by curcumin (2007) Cancer Res, 67, pp. 362-370
Choi, H., Chun, Y.S., Kim, S.W., Kim, M.S., Park, J.W., Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: A mechanism of tumor growth inhibition (2006) Mol Pharmacol, 70, pp. 1664-1671
Abuarqoub, H., Green, C.J., Foresti, R., Motterlini, R., Curcumin reduces cold storage-induced damage in human cardiac myoblasts (2007) Exp Mol Med, 39, pp. 139-148
Jeong, G.S., Oh, G.S., Pae, H.O., Jeong, S.O., Kim, Y.C., Shin, M.K., Seo, B.Y., Chung, H.T., Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: Ortho-methoxy groups are essential to enhance heme oxygenase activity and protection (2006) Exp Mol Med, 38, pp. 393-400
McNally, S.J., Harrison, E.M., Ross, J.A., Garden, O.J., Wigmore, S.J., Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury (2006) Transplantation, 81, pp. 623-626
Rushworth, S.A., Ogborne, R.M., Charalambos, C.A., O'Connell, M.A., Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes (2006) Biochem Biophys Res Commun, 341, pp. 1007-1016
Balogun, E., Foresti, R., Green, C.J., Motterlini, R., Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells (2003) Biochem Biophys Res Commun, 308, pp. 950-955
Andreadi, C.K., Howells, L.M., Atherfold, P.A., Manson, M.M., Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols (2006) Mol Pharmacol, 69, pp. 1033-1040
Rashmi, R., Santhosh Kumar, T.R., Karunagaran, D., Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases (2003) FEBS Lett, 538, pp. 19-24
Sood, A., Mathew, R., Trachtman, H., Cytoprotective effect of curcumin in human proximal tubule epithelial cells exposed to shiga toxin (2001) Biochem Biophys Res Commun, 283, pp. 36-41
Chen, Y.C., Tsai, S.H., Shen, S.C., Lin, J.K., Lee, W.R., Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells (2001) Eur J Cell Biol, 80, pp. 213-221
Chen, Y.C., Kuo, T.C., Lin-Shiau, S.Y., Lin, J.K., Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells (1996) Mol Carcinog, 17, pp. 224-234
Kato, K., Ito, H., Kamei, K., Iwamoto, I., Stimulation of the stress-induced expression of stress proteins by curcumin in cultured cells and in rat tissues in vivo (1998) Cell Stress Chaperones, 3, pp. 152-160
Fang, J., Lu, J., Holmgren, A., Thioredoxin reductase is irreversibly modified by curcumin: A novel molecular mechanism for its anticancer activity (2005) J Biol Chem, 280, pp. 25284-25290
Moi, P., Chan, K., Asunis, I., Cao, A., Kan, Y.W., Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region (1994) Proc Natl Acad Sci USA, 91, pp. 9926-9930
Talalay, P., Chemoprotection against cancer by induction of phase 2 enzymes (2000) Biofactors, 12, pp. 5-11
Nguyen, T., Scherratt, P.J., Pickett, C.B., Regulatory mechanisms controlling gene expression mediated by the antioxidant response element (2003) Annu Rev Pharmacol Toxicol, 43, pp. 233-260
Nioi, P., McMahon, M., Itoh, K., Yamamoto, M., Hayes, J.D., Identification of a novel Nrf2-regulated antioxidant response element (2003) Biochem J, 374, pp. 337-348
Prestera, T., Talalay, P., Alam, J., Ahn, Y.I., Lee, P.J., Choi, A.M., Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE) (1995) Mol Med, 1, pp. 827-837
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J.D., Yamamoto, M., Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain (1999) Genes Dev, 13, pp. 76-86
Motohashi, H., Yamamoto, M., Nrf2-Keap1 defines a physiologically important stress response mechanism (2004) Trends Mol Med, 10, pp. 549-557
Katsuoka, F., Motohashi, H., Ishii, T., Aburatani, H., Engel, J.D., Yamamoto, M., Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes (2005) Mol Cell Biol, 25, pp. 8044-8051
Lee, J.M., Li, J., Johnson, D.A., Stein, T.D., Kraft, A.D., Calkins, M.J., Jakel, R.J., Johnson, J.A., Nrf2, a multi-organ protector? (2005) FASEB J, 19, pp. 1061-1066
Kensler, T.W., Wakabayashi, N., Biswal, S., Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway (2007) Annu Rev Pharmacol Toxicol, 47, pp. 89-116
McMahon, M., Thomas, N., Itoh, K., Yamamoto, M., Hayes, J.D., Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: A two-site interaction model for the Nrf2-Keap1 complex (2006) J Biol Chem, 281, pp. 24756-24768
Kobayashi, M., Yamamoto, M., Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species (2006) Adv Enzyme Regul, 46, pp. 113-140
Rangasamy, T., Cho, C.Y., Thimmulappa, R.K., Zhen, L., Srisuma, S.S., Kensler, T.W., Yamamoto, M., Biswal, S., Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice (2004) J Clin Invest, 114, pp. 1248-1259
Rangasamy, T., Guo, G., Mitzner, W.A., Roman, J., Singh, A., Fryer, A.D., Yamamoto, M., Biswal, S., Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice (2005) J Exp Med, 202, pp. 47-59
Thimmulappa, R.K., Lee, H., Rangasamy, T., Reddy, S.P., Yamamoto, M., Kensler, T.W., Biswal, S., Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis (2006) J Clin Invest, 116, pp. 984-995
Zhang, X., Lu, L., Dixon, C., Wilmer, W., Song, H., Chen, X., Rovin, B.H., Stress protein activation by the cyclopentenone prostaglandin 15-deoxy-delta12, 14-prostaglandin J2 in human mesangial cells (2004) Kidney Int, 65, pp. 798-810
Rokutan, K., Miyoshi, M., Teshima, S., Kawai, T., Kawahara, T., Kishi, K., Phenylarsine oxide inhibits heat shock protein 70 induction in cultured guinea pig gastric mucosal cells (2000) Am J Physiol Cell Physiol, 279, pp. 1506-1515
Liu, H., Lightfoot, R., Stevens, J.L., Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols (1996) J Biol Chem, 271, pp. 4805-4812
Tabner, B.J., Turnbull, S., El-Agnaf, O., Allsop, D., Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases (2001) Curr Top Med Chem, 1, pp. 507-517
Barnham, K.J., Cappai, R., Beyreuther, K., Masters, C.L., Hill, A.F., Delineating common molecular mechanisms in Alzheimer's and prion diseases (2006) Trends Biochem Sci, 31, pp. 465-472
Hinault, M., Ben-Zvi, A., Goloubinoff, P., Chaperones and proteases: Cellular fold-controlling factors of proteins in neurodegenerative diseases and aging (2006) J Mol Neurosci, 30, pp. 249-265
Nakamura, T., Lipton, S.A., Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases (2007) Cell Mol Life Sci, 64, pp. 1609-1620
Schroder, M., The unfolded protein response (2006) Mol Biotechnol, 34, pp. 279-290
Schroder, M., Kaufman, R.J., The mammalian unfolded protein response (2005) Annu Rev Biochem, 74, pp. 739-789
Calabrese, V., Sultana, R., Scapagnini, G., Guagliano, E., Sapienza, M., Bella, R., Kanski, J., Butterfield, D.A., Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease (2006) Antioxid Redox Signal, 8, pp. 1975-1986
Katzman, R., Saitoh, T., Advances in Alzheimer's disease (1991) FASEB J, 5, pp. 278-286
Guix, F.X., Uribesalgo, I., Coma, M., Muñoz, F.J., The physiology and pathophysiology of nitric oxide in the brain (2005) Prog Neurobiol, 76, pp. 126-152
Kim, D.S., Park, S.Y., Kim, J.K., Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult (2001) Neurosci Lett, 303, pp. 57-61
Ono, K., Hasegawa, K., Naiki, H., Yamada, M., Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro (2004) J Neurosci Res, 75, pp. 742-750
Yang, F., Lim, G.P., Begum, A.N., Ubeda, O.J., Simmons, M.R., Ambegaokar, S.S., Chen, P.P., Cole, G.M., Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo (2005) J Biol Chem, 280, pp. 5892-5901
Voelker, R., Parkinson disease guidelines aid diagnosis, management (2006) JAMA, 295, pp. 2126-2128
Przedborski, S., Ischiropoulos, H., Reactive oxygen and nitrogen species: Weapons of neuronal destruction in models of Parkinson's disease (2005) Antioxid Redox Signal, 7, pp. 685-693
Hald, A., Lotharius, J., Oxidative stress and inflammation in Parkinson's disease: Is there a causal link? (2005) Exp Neurol, 193, pp. 279-290
Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D.M., Kopin, I.J., A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (1983) Proc Natl Acad Sci USA, 80, pp. 4546-4550
Chiueh, C.C., Andoh, T., Lai, A.R., Lai, E., Krishna, G., Neuroprotective strategies in Parkinson's disease: Protection against progressive nigral damage induced by free radicals (2000) Neurotox Res, 2, pp. 293-310
Rajeswari, A., Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (2006) Eur Rev Med Pharmacol Sci, 10, pp. 157-161
Chen, J., Tang, X.P., Zhi, J.L., Cui, Y., Yu, H.M., Tang, E.H., Sun, S.N., Chen, P.X., Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway (2006) Apoptosis, 11, pp. 943-953
Mythri, R.B., Jagatha, B., Pradhan, N., Andersen, J., Bharath, M.M., Mitochondrial complex I inhibition in Parkinson's disease: How can curcumin protect mitochondria? (2007) Antioxid Redox Signal, 9, pp. 399-408
Dürr, A., Cossee, M., Agid, Y., Campuzano, V., Mignard, C., Penet, C., Mandel, J.L., Koenig, M., Clinical and genetic abnormalities in patients with Friedreich's ataxia (1996) N Engl J Med, 335, pp. 1169-1175
Campuzano, V., Montermini, L., Moltò, M.D., Pianese, L., Cossée, M., Cavalcanti, F., Monros, E., Pandolfo, M., Friedreich's ataxia: Autosomal recessive disease caused by an intronic GAA triplet repeat expansion (1996) Science, 271, pp. 1423-1427
Bidichandani, S.I., Ashizawa, T., Patel, P.I., The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure (1998) Am J Hum Genet, 62, pp. 111-1121
Lamarche, J.B., Lemieux, B., Lieu, H.B., The neuropathology of "typical" Friedreich's ataxia in Quebec (1984) Can J Neurol Sci, 11, pp. 592-600
Delatycki, M.B., Paris, D.B., Gardner, R.J., Nicholson, G.A., Nassif, N., Storey, E., MacMillan, J.C., Forrest, S.M., Clinical and genetic study of Friedreich ataxia in an Australian population (1999) Am J Med Genet, 87, pp. 168-174
Montermini, L., Richter, A., Morgan, K., Justice, C.M., Julien, D., Castellotti, B., Mercier, J., Pandolfo, M., Phenotypic variability in Friedreich ataxia: Role of the associated GAA triplet repeat expansion (1997) Ann Neurol, 41, pp. 675-678
Filla, A., De Michele, G., Cavalcanti, F., Pianese, L., Monticelli, A., Campanella, G., Cocozza, S., The relationship between trinucleotide (GAA) repeat length and clinical features in Friedreich ataxia (1996) Am J Hum Genet, 59, pp. 554-560
Sakamoto, N., Ohshima, K., Montermini, L., Pandolfo, M., Wells, R.D., Sticky DNA, a selfassociated complex formed at long GAA*TTC repeats in intron 1 of the frataxin gene, inhibits transcription (2001) J Biol Chem, 276, pp. 27171-27177
Krasilnikova, M.M., Mirkin, S.M., Replication stalling at Friedreich's ataxia (GAA)n repeats in vivo (2004) Mol Cell Biol, 24, pp. 2286-2295
Barski, A., Cuddapah, S., Cui, K., Roh, T.Y., Schones, D.E., Wang, Z., Wei, G., Zhao, K., High-resolution profiling of histone methylations in the human genome (2007) Cell, 129, pp. 823-837
Herman, D., Jenssen, K., Burnett, R., Soragni, E., Perlman, S.L., Gottesfeld, J.M., Histonedeacetylase inhibitors reverse gene silencing in Friedreich's ataxia (2006) Nat Chem Biol, 2, pp. 551-558
Greene, E., Mahishi, L., Entezam, A., Kumari, D., Usdin, K., Repeat-induced epigenetic changes in intron 1 of the frataxin gene and its consequences in Friedreich ataxia (2007) Nucleic Acids Res, 35, pp. 3383-3390
Al-Mahdawi, S., Pinto, R.M., Ismail, O., Varshney, D., Lymperi, S., Sandi, C., Trabzuni, D., Pook, M., The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues (2008) Hum Mol Genet, 17, pp. 735-746
Sarsero, J.P., Li, L., Wardan, H., Sitte, K., Williamson, R., Ioannou, P.A., Upregulation of expression from the FRDA genomic locus for the therapy of Friedreich ataxia (2003) J Gene Med, 5, pp. 72-81
Bradley, J.L., Blake, J.C., Chamberlain, S., Thomas, P.K., Cooper, J.M., Schapira, A.H., Clinical, biochemical and molecular genetic correlations in Friedreich's ataxia (2000) Hum Mol Genet, 9, pp. 275-282
Babcock, M., De Silva, D., Oaks, R., Davis-Kaplan, S., Jiralerspong, S., Montermini, L., Pandolfo, M., Kaplan regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin (1997) Science, 276, pp. 1709-1712
Foury, F., Cazzalini, O., Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria (1997) FEBS Lett, 411, pp. 373-377
Koutnikova, H., Campuzano, V., Foury, F., Dollé, P., Cazzalini, O., Koenig, M., Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin (1997) Nat Genet, 16, pp. 345-351
Rötig, A., De Lonlay, P., Chretien, D., Foury, F., Koenig, M., Sidi, D., Munnich, A., Rustin, P., Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia (1997) Nat Genet, 17, pp. 215-217
Foury, F., Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain (1999) FEBS Lett, 456, pp. 281-284
Bulteau, A.L., O'Neill, H.A., Kennedy, M.C., Ikeda-Saito, M., Isaya, G., Szweda, L.I., Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity (2004) Science, 305, pp. 242-245
Piemonte, F., Pastore, A., Tozzi, G., Tagliacozzi, D., Santorelli, F.M., Carrozzo, R., Casali, C., Bertini, E., Glutathione in blood of patients with Friedreich's ataxia (2001) Eur J Clin Invest, 31, pp. 1007-1011
Schulz, J.B., Dehmer, T., Schöls, L., Mende, H., Hardt, C., Vorgerd, M., Bürk, K., Bogdanov, M.B., Oxidative stress in patients with Friedreich ataxia (2000) Neurology, 55, pp. 1719-1721
Emond, M., Lepage, G., Vanasse, M., Pandolfo, M., Increased levels of plasma malondialdehyde in Friedreich ataxia (2000) Neurology, 55, pp. 1752-1753
Bradley, J.L., Homayoun, S., Hart, P.E., Schapira, A.H., Cooper, J.M., Role of oxidative damage in Friedreich's ataxia (2004) Neurochem Res, 29, pp. 561-567
Santos, M.M., Ohshima, K., Pandolfo, M., Frataxin deficiency enhances apoptosis in cells differentiating into neuroectoderm (2001) Hum Mol Genet, 10, pp. 1935-1944
Sturm, B., Stupphann, D., Kaun, C., Boesch, S., Schranzhofer, M., Wojta, J., Goldenberg, H., Scheiber-Mojdehkar, B., Recombinant human erythropoietin: Effects on frataxin expression in vitro (2005) Eur J Clin Invest, 35, pp. 711-717
Boesch, S., Sturm, B., Hering, S., Goldenberg, H., Poewe, W., Scheiber-Mojdehkar, B., Friedreich's ataxia: Clinical pilot trial with recombinant human erythropoietin (2007) Ann Neurol, 62, pp. 521-524
Lodi, R., Hart, P.E., Rajagopalan, B., Taylor, D.J., Crilley, J.G., Bradley, J.L., Blamire, A.M., Cooper, J.M., Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia (2001) Ann Neurol, 49, pp. 590-596
Hart, P.E., Lodi, R., Rajagopalan, B., Bradley, J.L., Crilley, J.G., Turner, C., Blamire, A.M., Cooper, J.M., Antioxidant treatment of patients with Friedreich ataxia: Four-year follow-up (2005) Arch Neurol, 62, pp. 621-626
Rustin, P., Von Kleist-Retzow, J.C., Chantrel-Groussard, K., Sidi, D., Munnich, A., Rötig, A., Effect of idebenone on cardiomyopathy in Friedreich's ataxia: A preliminary study (1999) Lancet, 354, pp. 477-479
Hausse, A.O., Aggoun, Y., Bonnet, D., Sidi, D., Munnich, A., Rötig, A., Rustin, P., Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia (2002) Heart, 87, pp. 346-349
Buyse, G., Mertens, L., Di Salvo, G., Matthijs, I., Weidemann, F., Eyskens, B., Goossens, W., Van Hove, J.L., Idebenone treatment in Friedreich's ataxia: Neurological, cardiac, and biochemical monitoring (2003) Neurology, 60, pp. 1679-1681
Mariotti, C., Solari, A., Torta, D., Marano, L., Fiorentini, C., Di Donato, S., Idebenone treatment in Friedreich patients: One-year-long randomized placebo-controlled trial (2003) Neurology, 60, pp. 1676-1679
Di Prospero, N.A., Baker, A., Jeffries, N., Fischbeck, K.H., Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: A randomised, placebo-controlled trial (2007) Lancet Neurol, 6, pp. 878-886
Jauslin, M.L., Meier, T., Smith, R.A., Murphy, M.P., Mitochondria-targeted antioxidants protect Friedreich ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants (2003) FASEB J, 17, pp. 1972-1974
Al-Omar, F.A., Nagi, M.N., Abdulgadir, M.M., Al Joni, K.S., Al-Majed, A.A., Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus (2006) Neurochem Res, 31, pp. 611-618
Wang, Q., Sun, A.Y., Simonyi, A., Jensen, M.D., Shelat, P.B., Rottinghaus, G.E., MacDonald, R.S., Sun, G.Y., Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits (2005) J Neurosci Res, 82, pp. 138-148
Ghoneim, A.I., Abdel-Naim, A.B., Khalifa, A.E., El-Denshary, E.S., Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain (2002) Pharmacol Res, 46, pp. 273-279
Evans, A.M., Fornasini, G., Pharmacokinetics of L-carnitine (2003) Clin Pharmacokinet, 42, pp. 941-967
Rebouche, C.J., Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism (2004) Ann NY Acad Sci, 1033, pp. 30-41
Lombard, K.A., Olson, A.L., Nelson, S.E., Rebouche, C.J., Carnitine status of lactoovovegetarians and strict vegetarian adults and children (1989) Am J Clin Nutr, 50, pp. 301-306
Brass, E.P., Hoppel, C.L., Hiatt, W.R., Effect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans (1994) Clin Pharmacol Ther, 55, pp. 681-692
Gross, C.J., Savaiano, D.A., Effect of development and nutritional state on the uptake, metabolism and release of free and acetyl-L-carnitine by the rodent small intestine (1993) Biochim Biophys Acta, 1170, pp. 265-274
Parnetti, L., Gaiti, A., Mecocci, P., Cadini, D., Senin, U., Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type (1992) Eur J Clin Pharmacol, 42, pp. 89-93
Kelly, J.G., Hunt, S., Doyle, G.D., Laher, M.S., Carmody, M., Marzo, A., Arrigoni Martelli, E., Pharmacokinetics of oral acetyl-L-carnitine in renal impairment (1990) Eur J Clin Pharmacol, 38, pp. 309-312
McDaniel, M.A., Maier, S.F., Einstein, G.O., "brain-specific" nutrients: A memory cure? (2003) Nutrition, 19, pp. 957-975
Abdul, H.M., Calabrese, V., Calvani, M., Butterfield, D.A., Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease (2006) J Neurosci Res, 84, pp. 398-408
Calabrese, V., Colombrita, C., Sultana, R., Scapagnini, G., Calvani, M., Butterfield, D.A., Stella, A.M., Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: Relationship to antioxidant status and mitochondrial function (2006) Antioxid Redox Signal, 8, pp. 404-416
Rai, G., Wright, G., Scott, L., Beston, B., Rest, J., Exton-Smith, A.N., Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia (1990) Curr Med Res Opin, 11, pp. 638-647
Spagnoli, A., Lucca, U., Menasce, G., Bandera, L., Cizza, G., Forloni, G., Tettamanti, M., Comelli, M., Long-term acetyl-L-carnitine treatment in Alzheimer's disease (1991) Neurology, 41, pp. 1726-1732
Thal, L.J., Carta, A., Clarke, W.R., Ferris, S.H., Friedland, R.P., Petersen, R.C., Pettegrew, J.W., Woolson, R.F., A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease (1996) Neurology, 47, pp. 705-711
Thal, L.J., Calvani, M., Amato, A., Carta, A., A 1-year controlled trial of acetyl-l-carnitine in early-onset AD (2000) Neurology, 55, pp. 805-810
Calabrese, V., Ravagna, A., Colombrita, C., Guagliano, E., Scapagnini, G., Calvani, M., Butterfield, D.A., Giuffrida Stella, A.M., Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: Involvement of the transcription factor Nrf2 (2005) J Neurosci Res, 79, pp. 509-521
Snyder, S.H., Brain peptides as neurotransmitters (1980) Science, 209, pp. 976-983
Abe, H., Role of histidine-related compounds as intracellular proton buffering constituents in vertebrate muscle (2000) Biochemistry (Mosc), 65, pp. 757-765
Hipkiss, A.R., Preston, J.E., Himsworth, D.T., Worthington, V.C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N.J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann NY Acad Sci, 854, pp. 37-53
Bakardjiev, A., Biosynthesis of carnosine in primary cultures of rat olfactory bulb (1997) Neurosci Lett, 227, pp. 115-118
Teufel, M., Saudek, V., Ledig, J.P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase (2003) J Biol Chem, 278, pp. 6521-6531
Bauer, K., Barret, A.J., Rawlings, N.D., Woessner, J.F., X-His dipeptidase (2004) Handbook of Proteolytic Enzymes, pp. 1023-1024. , 2 Elsevier Amsterdam
De Marchis, S., Modena, C., Peretto, P., Giffard, C., Fasolo, A., Carnosine-like immunoreactivity in the central nervous system of rats during postnatal development (2000) J Comp Neurol, 426, pp. 378-390
Bauer, K., Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brain (2005) Neurochem Res, 30, pp. 1339-1345
McFarland, G.A., Holliday, R., Retardation of senescence in cultured human diploid fibroblasts by carnosine (1994) Exp Cell Res, 212, pp. 167-175
Yuneva, A.O., Kramarenko, G.G., Vetreshchak, T.V., Gallant, S., Boldyrev, A.A., Effect of carnosine on Drosophila melanogaster lifespan (2002) Bull Exp Biol Med, 133, pp. 559-561
Yuneva, A.O., Bulygina, E.R., Gallant, S., Kramarenko, G.G., Stvolinsky, S.L., Semyonova, M.L., Boldyrev, A.A., Effect of carnosine on age-induced changes in senescence-accelerated mice (1999) J Anti-Aging Med, 2, pp. 337-342
Babizhayev, M.A., Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care products (2006) Life Sci, 78, pp. 2343-2357
Lee, Y., Hsu, C., Lin, M., Liu, K., Yin, M., Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation (2005) Eur J Pharmacol, 512, pp. 145-150
Rashid, I., Van Reyk, D.M., Davies, M.J., Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro (2007) FEBS Letts, 581, pp. 1067-1070
Sauerhofer, S., Yuan, G., Braun, G.S., Deizer, M., Neumaier, M., Gretz, N., Floege, J., Moeller, M.J., L-Carnosine, a substrate of carnosinase-1, influences glucose metabolism (2007) Diabetes, 56, pp. 2425-2432
Hipkiss, A.R., Glycation, aging and carnosine: Are carnivorous diets beneficial? (2005) Mech Ageing Dev, 126, pp. 1034-1039
Huang, Y., Duan, J., Chen, H., Chen, M., Chen, G., Separation and determination of carnosine-related peptides using capillary electrophoresis with laser-induced fluorescence detection (2005) Electrophoresis, 26, pp. 593-599
Dobrota, D., Fedorova, T., Stvolinsky, S., Babusikova, E., Likavcanova, K., Drgova, A., Strapkova, A., Boldyrev, A., Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: After-stroke-effect (2005) Neurochem Res, 30, pp. 1283-1288
Stvolinsky, S., Kukley, M., Dobrota, D., Mezesova, V., Boldyrev, A., Carnosine protects rats under global ischemia (2000) Brain Res Bull, 53, pp. 445-448
Tang, S., Arumugam, T.V., Cutler, R.G., Jo, D., Magnus, T., Chan, S.L., Mughal, M.R., Mattson, M.P., (2007) J Neurochem, 101, pp. 729-736
Pubill, D., Verdaguer, E., Sureda, F.X., Camins, A., Pallas, M., Camarasa, J., Escubedo, E., Carnosine prevents methamphetamine-induced gliosis but not dopamine terminal loss in rats (2002) Eur J Pharmacol, 448, pp. 165-168
Dukic-Stefanovic, S., Schinzel, R., Riederer, P., Munch, G., AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs? (2001) Biogerontology, 2, pp. 19-34
Trombley, P.Q., Horning, M.S., Blakemore, L.J., Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmission (1998) Neuroreport, 9, pp. 3503-3507
Preston, J.E., Hipkiss, A.R., Himsworth, D.T., Romero, I.A., Abbott, J.N., Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: Protection by carnosine, homocarnosine and beta-alanine (1998) Neurosci Lett, 242, pp. 105-108
Fu, Q., Dai, H., Hu, W., Fan, Y., Zhang, Y., Chen, Z., Carnosine protects against Aβ-42-induced neurotoxicity in differentiated rat PC12 cells (2008) Cell Mol Neurobiol, 28, pp. 307-316
Shen, Y., Hu, W., Dai, H., Fu, Q., Wei, E., Luo, J., Chen, Z., Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H 1/H3 receptors (2007) Biochem Pharmacol, 73, pp. 709-717
Fonteh, A.N., Harrington, R.J., Tsai, A., Liao, P., Harrington, M.G., Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects (2007) Amino Acids, 32, pp. 213-224
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell Mol Life Sci, 59, pp. 546-551
Severina, I.S., Bussygina, O.G., Pyatakova, N.V., Carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 783-788
Nicoletti, V.G., Santoro, A.M., Grasso, G., Vagliasindi, L.I., Giuffrida, M.L., Cuppari, C., Spina Purrello, V., Rizzarelli, E., Carnosine interaction with nitric oxide and astroglial protection (2007) J Neurosci Res, 85, pp. 2239-2245
La Mendola, D., Sortino, S., Vecchio, G., Rizzarelli, E., Synthesis of new carnosine derivatives of β-cyclodextrin and their hydroxyl scavenger ability (2002) Helv Chim Acta, 85, pp. 1633-1643
Bonomo, R.P., Bruno, V., Conte, E., De Guidi, G., La Mendola, D., Maccarrone, G., Nicoletti, F., Vecchio, G., Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (2003) J Chem Soc Dalton Trans, pp. 4406-4415
Mineo, P., Vitalini, D., La Mendola, D., Rizzarelli, E., Scamporrino, E., Vecchio, G., ESI-MS and spectroscopic investigations on 6A, 6D-di-(β-alanyl-L- histidine)-6A, 6D-dideoxy-β-cyclodextrin and 6A, 6C-di-(β-alanyl-L- histidine)-6A, 6C-dideoxy-β-cyclodextrin and their copper(II) complexes (2004) J Inorg Biochem, 98, pp. 254-265
Bellia, F., La Mendola, D., MacCarrone, G., Mineo, P., Vitalizi, D., Scamporrino, E., Sortino, S., Rizzarelli, E., Copper(II) complexes with β-cyclodextrin-homocarnosine conjugates and their antioxidant activity (2007) Inorg Chim Acta, 360, pp. 949-954
Amorini, A.M., Bellia, F., Di Pietro, V., Giardina, B., La Mendola, D., Lazzarino, G., Sortino, S., Vecchio, G., Synthesis and antioxidant activity of new homocarnosine β-cyclodextrin conjugates (2007) Eur J Med Chem, 42, pp. 910-920
Bellia, F., Amorini, A.M., La Mendola, D., Vecchio, G., Gavazzi, B., Giardina, B., Di Pietro, V., Rizzarelli, E., New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (2008) Eur J Med Chem, 43, pp. 373-380
Adlard, P.A., Bush, A.I., Metals and Alzheimer's disease (2006) J Alzheimer's Dis, 10, pp. 145-163
Chrouch, P.J., White, A.R., Bush, A.I., The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease (2007) FEBS J, 274, pp. 375-3783
Wenzel, E., Somoza, V., Metabolism and bioavailability of trans-resveratrol (2005) Mol Nutr Food Res, 49, pp. 472-481
Walle, T., Hsieh, F., Delegge, M.H., Oatis Jr., J.E., Walle, U.K., High absorption but very low bioavailability of oral resveratrol in humans (2004) Drug Metab Dispos, 32, pp. 1377-1382
Soleas, G.J., Angelini, M., Grass, L., Diamandis, E.P., Goldberg, D.M., Absorption of trans-resveratrol in rats (2001) Methods Enzymol, 335, pp. 145-154
Jannin, B., Menzel, M., Berlot, J.P., Delmas, D., Lançon, A., Latruffe, N., Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: Plasmatic protein binding and cell uptake (2004) Biochem Pharmacol, 68, pp. 1113-1118
Zhou, S., Koh, H.L., Gao, Y., Gong, Z.Y., Lee, E.J., Herbal bioactivation: The good, the bad and the ugly (2004) Life Sci, 74, pp. 935-968
Cao, Z., Li, Y., Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: Protection against oxidative and electrophilic injury (2004) Eur J Pharmacol, 489, pp. 39-48
Asensi, M., Medina, I., Ortega, A., Carretero, J., Baño, M.C., Obrador, E., Estrela, J.M., Inhibition of cancer growth by resveratrol is related to its low bioavailability (2002) Free Radic Biol Med, 33, pp. 387-398
Kim, Y.A., Kim, G.Y., Park, K.Y., Choi, Y.H., Resveratrol inhibits nitric oxide and prostaglandin E2 production by lipopolysaccharide-activated C6 microglia (2007) J Med Food, 10, pp. 218-224
Anekonda, T.S., Resveratrol-a boon for treating Alzheimer's disease? (2006) Brain Res Rev, 52, pp. 316-326
Jang, J.H., Surh, Y.J., Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death (2003) Free Radic Biol Med, 34, pp. 1100-1110
Bastianetto, S., Brouillette, J., Quirion, R., Neuroprotective effects of natural products: Interaction with intracellular kinases, amyloid peptides and a possible role for transthyretin (2007) Neurochem Res, 32, pp. 1720-1725
Marambaud, P., Zhao, H., Davies, P., Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides (2005) J Biol Chem, 280, pp. 37377-37382
Bastianetto, S., Zheng, W.H., Quirion, R., Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons (2000) Br J Pharmacol, 131, pp. 711-720
Sharma, M., Gupta, Y.K., Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats (2002) Life Sci, 71, pp. 2489-2498
Anekonda, T.S., Reddy, P.H., Neuronal protection by sirtuins in Alzheimer's disease (2006) J Neurochem, 96, pp. 305-313
Chen, C.Y., Jang, J.H., Li, M.H., Surh, Y.J., Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells (2005) Biochem Biophys Res Commun, 331, pp. 993-1000
Zhuang, H., Kim, Y.S., Koehler, R.C., Doré, S., Potential mechanism by which resveratrol, a red wine constituent, protects neurons (2003) Ann NY Acad Sci, 993, pp. 276-286
Takahashi, M., Doré, S., Ferris, C.D., Tomita, T., Sawa, A., Wolosker, H., Borchelt, D.R., Snyder, S.H., Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease (2000) Neuron, 28, pp. 461-473
Halliwell, B., Biochemistry of oxidative stress (2007) Biochem Soc Trans, 35, pp. 1147-1150
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D.A., Giuffrida Stella, A.M., Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity (2007) Nat Rev Neurosci, 8, pp. 766-775
Hagen, T.M., Liu, J., Lykkesfeldt, J., Wehr, C.M., Ingersoll, R.T., Vinarsky, V., Bartholomew, J.C., Ames, B.N., Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress (2002) Proc Natl Acad Sci USA, 99, pp. 1870-1875
Hagen, T.M., Moreau, R., Suh, J.H., Visioli, F., Mitochondrial decay in the aging rat heart: Evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid (2002) Ann NY Acad Sci, 959, pp. 491-507
Liu, J., Head, E., Gharib, A.M., Yuan, W., Ingersoll, R.T., Hagen, T.M., Cotman, C.W., Ames, B.N., Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid (2002) Proc Natl Acad Sci USA, 99, pp. 2356-2361
Atamna, H., Nguyen, A., Schultz, C., Boyle, K., Newberry, J., Kato, H., Ames, B.N., Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways (2008) FASEB J, 22, pp. 703-712
Milgram, N.W., Araujo, J.A., Hagen, T.M., Treadwell, B.V., Ames, B.N., Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests (2007) FASEB J, 21, pp. 3756-3762
Calabrese, E., Hormesis: Why it is important to toxicology and toxicologists (2008) Environ Toxicol Chem, 14, p. 1
Calabrese, E.J., Another california milestone: The first application of hormesis in litigation and regulation (2008) Int J Toxicol, 27, pp. 31-33
Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity
The predominant molecular symptom of aging is the accumulation of altered gene products. Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox homeostasis and lead to accumulation of unfolded or misfolded proteins in the aging brain. Alzheimer's and Parkinson's diseases or Friedreich ataxia are neurological diseases sharing, as a common denominator, production of abnormal proteins, mitochondrial dysfunction and oxidative stress, which contribute to the pathogenesis of these so called "protein conformational diseases". The central nervous system has evolved the conserved mechanism of unfolded protein response to cope with the accumulation of misfolded proteins. As one of the main intracellular redox systems involved in neuroprotection, the vitagene system is emerging as a neurohormetic potential target for novel cytoprotective interventions. Vitagenes encode for cytoprotective heat shock proteins (Hsp) Hsp70 and heme oxygenase-1, as well as thioredoxin reductase and sirtuins. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Thus, the impact of dietary factors on health and longevity is an increasingly appreciated area of research. Reducing energy intake by controlled caloric restriction or intermittent fasting increases lifespan and protects various tissues against disease. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin, a group of proteins linked to aging, metabolism and stress tolerance in several organisms. Recent findings suggest that several phytochemicals exhibit biphasic dose responses on cells with low doses activating signaling pathways that result in increased expression of vitagenes encoding survival proteins, as in the case of the Keap1/Nrf2/ARE pathway activated by curcumin and NAD/NADH-sirtuin-1 activated by resveratrol. Consistently, the neuroprotective roles of dietary antioxidants including curcumin, acetyl-L-carnitine and carnosine have been demonstrated through the activation of these redox-sensitive intracellular pathways. Although the notion that stress proteins are neuroprotective is broadly accepted, still much work needs to be done in order to associate neuroprotection with specific pattern of stress responses. In this review the importance of vitagenes in the cellular stress response and the potential use of dietary antioxidants in the prevention and treatment of neurodegenerative disorders is discussed.
The predominant molecular symptom of aging is the accumulation of altered gene products. Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox homeostasis and lead to accumulation of unfolded or misfolded proteins in the aging brain. Alzheimer's and Parkinson's diseases or Friedreich ataxia are neurological diseases sharing, as a common denominator, production of abnormal proteins, mitochondrial dysfunction and oxidative stress, which contribute to the pathogenesis of these so called "protein conformational diseases". The central nervous system has evolved the conserved mechanism of unfolded protein response to cope with the accumulation of misfolded proteins. As one of the main intracellular redox systems involved in neuroprotection, the vitagene system is emerging as a neurohormetic potential target for novel cytoprotective interventions. Vitagenes encode for cytoprotective heat shock proteins (Hsp) Hsp70 and heme oxygenase-1, as well as thioredoxin reductase and sirtuins. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Thus, the impact of dietary factors on health and longevity is an increasingly appreciated area of research. Reducing energy intake by controlled caloric restriction or intermittent fasting increases lifespan and protects various tissues against disease. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin, a group of proteins linked to aging, metabolism and stress tolerance in several organisms. Recent findings suggest that several phytochemicals exhibit biphasic dose responses on cells with low doses activating signaling pathways that result in increased expression of vitagenes encoding survival proteins, as in the case of the Keap1/Nrf2/ARE pathway activated by curcumin and NAD/NADH-sirtuin-1 activated by resveratrol. Consistently, the neuroprotective roles of dietary antioxidants including curcumin, acetyl-L-carnitine and carnosine have been demonstrated through the activation of these redox-sensitive intracellular pathways. Although the notion that stress proteins are neuroprotective is broadly accepted, still much work needs to be done in order to associate neuroprotection with specific pattern of stress responses. In this review the importance of vitagenes in the cellular stress response and the potential use of dietary antioxidants in the prevention and treatment of neurodegenerative disorders is discussed.
Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity
No results. |
Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity
Other filter: ([btitle,keywords] "Antioxidants" OR [bt ...
Pepe G, Calce E, Verdoliva V, Saviano M, Maglione V, Di Pardo A, De Luca S
* Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders (60 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Nov 23; 21(22): N/D-N/D.
Impact Factor: 4.556
View Export to BibTeX Export to EndNote
Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (288 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
View Export to BibTeX Export to EndNote
Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E
* Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna (91 views)
Aquat Toxicol (ISSN: 0166-445xlinking), 2018 May; 198: 158-164.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Grasso GI, Bellia F, Arena G, Satriano C, Vecchio G, Rizzarelli E
* Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity (417 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jul 28; 135: 447-457.
Impact Factor: 4.816
View Export to BibTeX Export to EndNote
Sandomenico A, Severino V, Apone F, De Lucia A, Caporale A, Doti N, Russo A, Russo R, Rega C, Del Giacco T, Falcigno L, Ruvo M, Chambery A
* Trifluoroacetylated tyrosine-rich D-tetrapeptides have potent antioxidant activity (401 views)
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2017 Mar; 89: 50-59.
Impact Factor: 2.851
View Export to BibTeX Export to EndNote
Monti S, Cocozza S, Borrelli P, Straub S, Ladd ME, Salvatore M, Tedeschi E, Palma G
* MAVEN: An Algorithm for Multi-Parametric Automated Segmentation of Brain Veins from Gradient Echo Acquisitions (222 views) (PDF 188 views)
Ieee T Med Imaging (ISSN: 0278-0062), 2017; 36(5): 1054-1065.
Impact Factor: 6.131
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (943 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
* Combination of Abeta Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC (353 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Pietropaolo A, Vecchio G
* Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (684 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015; 21(40): 14047-14059.
Impact Factor: 5.771
View Export to BibTeX Export to EndNote
Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (709 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
View Export to BibTeX Export to EndNote
Vitagliano L, Zaccaro L, Morelli G, Martegani E
* Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders (341 views)
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2013 Jun 11; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (522 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (647 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (4460 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (893 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S
* Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (375 views)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Impact Factor: 3.787
View Export to BibTeX Export to EndNote
Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (698 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
View Export to BibTeX Export to EndNote
Pedone E, Limauro D, Bartolucci S
* Erratum: The machinery for oxidative protein folding in thermophiles (Antioxidants and Redox Signaling (2008) 10 (157-169)) (383 views)
Antioxid Redox Signal (ISSN: 1523-0864, 1557-7716, 1523-0864linking), 2010; 12(1): 171-179.
Impact Factor: 8.209
View Export to BibTeX Export to EndNote
Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E
* Carnosinase levels in aging brain: redox state induction and cellular stress response (516 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1091 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1423 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
View Export to BibTeX Export to EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (398 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (378 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (441 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Caridi A, Cufari A, Lovino R, Palumbo R, Tedesco I
* Influence of Yeast on Polyphenol Composition of Wine (243 views)
Food Technol Biotechnol (ISSN: 1330-9862), 2004 Jan; 42(1): 37-40.
Impact Factor: 0.475
View Export to BibTeX Export to EndNote
Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (385 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
Impact Factor: 2.908
View Export to BibTeX Export to EndNote
Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (1166 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
View Export to BibTeX Export to EndNote
Monti SM, Ritieni A, Sacchi R, Skog K, Borgen E, Fogliano V
* Characterization of phenolic compounds in virgin olive oil and their effect on the formation of carcinogenic/mutagenic heterocyclic amines in a model system (644 views)
J Agric Food Chem (ISSN: 0021-8561), 2001 Sep; 49(8): 3969-3975.
Impact Factor: 1.576
View Export to BibTeX Export to EndNote
Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (601 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
View Export to BibTeX Export to EndNote
Monti SM, Borrelli RC, Ritieni A, Fogliano V
A comparison of color formation and Maillard reaction products of a lactose-lysine and lactose-N(α)-acetyllysine model system (488 views)
J Agric Food Chem (ISSN: 0021-8561), 2000; 48(4): 1041-1046.
Impact Factor: 1.56
View Export to BibTeX Export to EndNote
Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (351 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
View Export to BibTeX Export to EndNote
Costanzo LL, De Guidi G, Giuffrida S, Sortino S, Condorelli G, Pappalardo G
Antioxidant effect of copper(II) on photosensitized lipid peroxidation (610 views)
J Chem Res (ISSN: 0162-0134print, 0162-0134linking, 1873-3344), 1995 Feb; 57(2): 115-125.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
* Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders (60 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Nov 23; 21(22): N/D-N/D.
Impact Factor: 4.556
View Export to BibTeX Export to EndNote
Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (288 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
View Export to BibTeX Export to EndNote
Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E
* Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna (91 views)
Aquat Toxicol (ISSN: 0166-445xlinking), 2018 May; 198: 158-164.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Grasso GI, Bellia F, Arena G, Satriano C, Vecchio G, Rizzarelli E
* Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity (417 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jul 28; 135: 447-457.
Impact Factor: 4.816
View Export to BibTeX Export to EndNote
Sandomenico A, Severino V, Apone F, De Lucia A, Caporale A, Doti N, Russo A, Russo R, Rega C, Del Giacco T, Falcigno L, Ruvo M, Chambery A
* Trifluoroacetylated tyrosine-rich D-tetrapeptides have potent antioxidant activity (401 views)
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2017 Mar; 89: 50-59.
Impact Factor: 2.851
View Export to BibTeX Export to EndNote
Monti S, Cocozza S, Borrelli P, Straub S, Ladd ME, Salvatore M, Tedeschi E, Palma G
* MAVEN: An Algorithm for Multi-Parametric Automated Segmentation of Brain Veins from Gradient Echo Acquisitions (222 views) (PDF 188 views)
Ieee T Med Imaging (ISSN: 0278-0062), 2017; 36(5): 1054-1065.
Impact Factor: 6.131
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (943 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
* Combination of Abeta Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC (353 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Pietropaolo A, Vecchio G
* Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (684 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015; 21(40): 14047-14059.
Impact Factor: 5.771
View Export to BibTeX Export to EndNote
Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (709 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
View Export to BibTeX Export to EndNote
Vitagliano L, Zaccaro L, Morelli G, Martegani E
* Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders (341 views)
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2013 Jun 11; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (522 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (647 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (4460 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (893 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
Limauro D, D'Ambrosio K, Langella E, De Simone G, Galdi I, Pedone C, Pedone E, Bartolucci S
* Exploring the catalytic mechanism of the first dimeric Bcp: Functional, structural and docking analyses of Bcp4 from Sulfolobus solfataricus (375 views)
Biochimie (ISSN: 1638-6183, 0300-9084, 1638-6183electronic), 2010 Oct; 92(10): 1435-1444.
Impact Factor: 3.787
View Export to BibTeX Export to EndNote
Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (698 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
View Export to BibTeX Export to EndNote
Pedone E, Limauro D, Bartolucci S
* Erratum: The machinery for oxidative protein folding in thermophiles (Antioxidants and Redox Signaling (2008) 10 (157-169)) (383 views)
Antioxid Redox Signal (ISSN: 1523-0864, 1557-7716, 1523-0864linking), 2010; 12(1): 171-179.
Impact Factor: 8.209
View Export to BibTeX Export to EndNote
Bellia F, Calabrese V, Guarino F, Cavallaro M, Cornelius C, De Pinto V, Rizzarelli E
* Carnosinase levels in aging brain: redox state induction and cellular stress response (516 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1091 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1423 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
View Export to BibTeX Export to EndNote
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (398 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (378 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (441 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Caridi A, Cufari A, Lovino R, Palumbo R, Tedesco I
* Influence of Yeast on Polyphenol Composition of Wine (243 views)
Food Technol Biotechnol (ISSN: 1330-9862), 2004 Jan; 42(1): 37-40.
Impact Factor: 0.475
View Export to BibTeX Export to EndNote
Bonomo RP, Bruno V, Conte E, De Guidi G, La Mendola D, Maccarrone G, Nicoletti F, Rizzarelli E, Sortino S, Vecchio G
* Potentiometric, spectroscopic and antioxidant activity studies of SOD mimics containing carnosine (385 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2003; (23): 4406-4415.
Impact Factor: 2.908
View Export to BibTeX Export to EndNote
Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (1166 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
View Export to BibTeX Export to EndNote
Monti SM, Ritieni A, Sacchi R, Skog K, Borgen E, Fogliano V
* Characterization of phenolic compounds in virgin olive oil and their effect on the formation of carcinogenic/mutagenic heterocyclic amines in a model system (644 views)
J Agric Food Chem (ISSN: 0021-8561), 2001 Sep; 49(8): 3969-3975.
Impact Factor: 1.576
View Export to BibTeX Export to EndNote
Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (601 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
View Export to BibTeX Export to EndNote
Monti SM, Borrelli RC, Ritieni A, Fogliano V
A comparison of color formation and Maillard reaction products of a lactose-lysine and lactose-N(α)-acetyllysine model system (488 views)
J Agric Food Chem (ISSN: 0021-8561), 2000; 48(4): 1041-1046.
Impact Factor: 1.56
View Export to BibTeX Export to EndNote
Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (351 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
View Export to BibTeX Export to EndNote
Costanzo LL, De Guidi G, Giuffrida S, Sortino S, Condorelli G, Pappalardo G
Antioxidant effect of copper(II) on photosensitized lipid peroxidation (610 views)
J Chem Res (ISSN: 0162-0134print, 0162-0134linking, 1873-3344), 1995 Feb; 57(2): 115-125.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
34 Records (32 excluding Abstracts).
Total impact factor: 137.378 (136.036 excluding Abstracts).
Total 5 year impact factor: 147.845 (144.463 excluding Abstracts).
Total impact factor: 137.378 (136.036 excluding Abstracts).
Total 5 year impact factor: 147.845 (144.463 excluding Abstracts).
1387 views. Last view on Sunday 14 May 2023, 10:20:40
ibb.cnr.it
