Carnosinase levels in aging brain: redox state induction and cellular stress response (430 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 7.581, 5-year impact factor: 6.853
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-73449088037&partnerID=40&md5=5ea951d323dac4074fff57266df9d5d3
Keywords: Antibody, Carbonyl Derivative, Carnosinase Cn1, Dipeptidase, Glutathione, Heat Shock Protein 72, Heme Oxygenase 1, Recombinant Enzyme, Thiol Derivative, Thioredoxin, Thioredoxin Reductase, Unclassified Drug, Aminoacyl-Histidine Dipeptidase, Aminoacylhistidine Dipeptidase, Aging, Animal Tissue, Antibody Production, Brain, Brain Cortex, Cell Line, Cellular Stress Response, Cerebellum, Corpus Striatum, Enzyme Activity, Genetic Transfection, Hippocampus, Nitrosative Stress, Nonhuman, Oxidation Reduction Reaction, Oxidative Stress, Priority Journal, Protein Analysis, Purification, Review, Senescence, Septum Nucleus, Substantia Nigra, Article, Enzyme Linked Immunosorbent Assay, Enzymology, Hela Cell, Immunohistochemistry, Mass Spectrometry, Metabolism, Physiology, Polymerase Chain Reaction, Wistar Rat, Enzyme-Linked Immunosorbent Assay, Hsp72 Heat-Shock Proteins, Oxidation-Reduction, Thioredoxin-Disulfide Reductase,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Catania , Catania Section, Catania, Italy.
Institute of Biostructures and Bioimages, CNR, Catania Section, Catania, Italy
National Institute of Biosystems and Biostructures, Catania Section, Catania, Italy
References:
Abdul, H.M., Calabrese, V., Calvani, M., Butterfield, D.A., Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease (2006) J Neurosci Res, 84, pp. 398-40
Amorini, A.M., Bellia, F., Di Pietro, V., Giardina, B., La Mendola, D., Lazzarino, G., Sortino, S., Vecchio, G., Synthesis and antioxidant activity of new homocarnosine b-cyclodextrin conjugates (2007) Eur J Med Chem, 42, pp. 910-920
Balion, C.M., Benson, C., Raina, P.S., Papaioannou, A., Patterson, C., Ismaila, A.S., Brain type carnosinase in dementia: A pilot study (2007) BMC Neurol, 7, p. 38
Bauer, K., Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brain (2005) Neurochem Res, 30, pp. 1339-1345
Bellia, F., Amorini, A.M., La Mendola, D., Vecchio, G., Tavazzi, B., Giardina, B., Di Pietro, V., Rizzarelli, E., New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (2008) Eur J Med Chem, 43, pp. 373-380
Boldyrev, A.A., Severin, S.E., The histidine-containing dipeptides, carnosine and anserine: Distribution, properties and biological significance (1990) Adv Enzyme Regul, 30, pp. 175-194
Boldyrev, A.A., Yuneva, M.O., Sorokina, E.V., Kramarenko, G.G., Fedorova, T.N., Konovalova, G.G., Lankin, V.Z., Antioxidant systems in tissues of senescence accelerated mice (2001) Biochemistry (Mosc), 66, pp. 1157-1163
Butterfield, D.A., Stadtman, E.R., Protein oxidation processes in aging brain (1997) Adv Cell Aging Gerontol, 2, pp. 161-191
Calabrese, V., Butterfield, D.A., Stella, A.M., Aging and oxidative stress response in the CNS (2008) Handbook of Neurochemistry and Molecular Neurobiology, pp. 128-134. , edited by Lajtha A, Perez-Polo JR, Rossner S. New York: Springer
Calabrese, V., Colombrita, C., Guagliano, E., Sapienza, M., Ravagna, A., Cardile, V., Scapagnini, G., Rizzarelli, E., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem Res, 30, pp. 797-807
Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Calabrese, E.J., Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis (2009) Biofactors, 35, pp. 146-160
Calabrese, V., Guagliano, E., Sapienza, M., Panebianco, M., Calafato, S., Puleo, E., Pennisi, G., Stella, A.G., Redox regulation of cellular stress response in aging and neurodegenerative disorders: Role of vitagenes (2007) Neurochem Res, 32, pp. 757-773
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D.A., Stella, A.M., Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity (2007) Nat Rev Neurosci, 8, pp. 766-775
Calabrese, V., Sultana, R., Scapagnini, G., Guagliano, E., Sapienza, M., Bella, R., Kanski, J., Butterfield, D.A., Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease (2006) Antioxid Redox Signal, 8, pp. 1975-1986
Crush, K.G., Carnosine and related substances in animal tissues (1970) Comp Biochem Physiol, 34, pp. 3-30
De Leon, M.J., George, A.E., Golomb, J., Tarshish, C., Convit, A., Kluger, A., De Santi, S., Wisniewski, H.M., Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease (1997) Neurobiology of Aging, 18 (1), pp. 1-11. , DOI 10.1016/S0197-4580(96)00213-8, PII S0197458096002138
Dobrota, D., Fedorova, T., Stvolinsky, S., Babusikova, E., Likavcanova, K., Drgova, A., Strapkova, A., Boldyrev, A., Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: After-stroke effect (2005) Neurochem Res, 30, pp. 1283-1288
Dukic-Stefanovic, S., Schinzel, R., Riederer, P., Munch, G., AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs? (2001) Biogerontology, 2, pp. 19-34
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell Mol Life Sci, 59, pp. 546-551
Fu, Q., Dai, H., Hu, W., Fan, Y., Shen, Y., Zhang, W., Chen, Z., Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells (2008) Cell Mol Neurobiol, 28, pp. 307-316
Gerschman, R., Gilbert, D.L., Nye, S.W., Dwyer, P., Fenn, W.O., Oxygen poisoning and x-irradiation: A mechanism in common (1954) Science, 119, pp. 623-626
Gobom, J., Nordhoff, E., Mirgorodskaya, E., Ekman, R., Roepstorff, P., Sample purification and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrix-assisted laser desorption=ionization mass spectrometry (1999) J Mass Spectrom, 34, pp. 105-116
Gruber, J., Schaffer, S., Halliwell, B., The mitochondrial free radical theory of ageing: Where do we stand? (2008) Front Biosci, 13, pp. 6554-6579
Gulewitsch, W., Amiradzibi, S., Carnosine, a new organic base from meat extracts (1900) Ber Dtsch Chem Ges, 33, pp. 1902-1903
Hamm-Alvarez, S., Cadenas, E., Mitochondrial medicine and mitochondrion-based therapeutics (2008) Adv Drug Deliv Rev, 60, pp. 1437-1438
Harman, D., Aging: A theory based on free radical and radiation chemistry (1956) J Gerontol, 11, pp. 298-300
Harman, D., Free radical theory of aging: An update: Increasing the functional life span (2006) Ann N y Acad Sci, 1067, pp. 10-21
Heales, S.J., Bolanos, J.P., Clark, J.B., Glutathione depletion is accompanied by increased neuronal nitric oxide synthase activity (1996) Neurochem Res, 21, pp. 35-39
Hipkiss, A.R., Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptide (2005) Biogerontology, 6, pp. 147-149
Hipkiss, A.R., Glycation, ageing and carnosine: Are carnivorous diets beneficial? (2005) Mech Ageing Dev, 126, pp. 1034-1039
Hipkiss, A.R., On the enigma of carnosine's anti-ageing actions (2009) Exp Gerontol, 44, pp. 237-242
Hipkiss, A.R., Preston, J.E., Himsworth, D.T., Worthington, V.C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N.J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann N y Acad Sci, 854, pp. 37-53
Huang, Y., Duan, J., Chen, H., Chen, M., Chen, G., Separation and determination of carnosine-related peptides using capillary electrophoresis with laser-induced fluorescence detection (2005) Electrophoresis, 26 (3), pp. 593-599. , DOI 10.1002/elps.200406130
Jackson, M.C., Kucera, C.M., Lenney, J.F., Purification and properties of human serum carnosinase (1991) Clin Chim Acta, 196, pp. 193-205
Jin, C.L., Yang, L.X., Wu, X.H., Li, Q., Ding, M.P., Fan, Y.Y., Zhang, W.P., Chen, Z., Effects of carnosine on amygdaloidkindled seizures in Sprague-Dawley rats (2005) Neuroscience, 135, pp. 939-947
Killiany, R.J., Moss, M.B., Albert, M.S., Sandor, T., Tieman, J., Jolesz, F., Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease (1993) Arch Neurol, 50, pp. 949-954
La Mendola, D., Sortino, S., Vecchio, G., Rizzarelli, E., Synthesis of new carnosine derivatives of b-cyclodextrin and their hydroxyl radical scavenger ability (2002) Helv Chim Acta, 85, pp. 1633-1643
Lam, P.Y., Yin, F., Hamilton, R.T., Boveris, A., Cadenas, E., Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production (2009) Free Radic Res, 43, pp. 431-439
Lenney, J.F., George, R.P., Weiss, A.M., Kucera, C.M., Chan, P.W., Rinzler, G.S., Human serum carnosinase: Characterization, distinction from cellular carnosinase, and activation by cadmium (1982) Clin Chim Acta, 123, pp. 221-231
Lenney, J.F., Peppers, S.C., Kucera-Orallo, C.M., George, R.P., Characterization of human tissue carnosinase (1985) Biochem J, 228, pp. 653-660
Lovell, M.A., Xie, C., Gabbita, S.P., Markesbery, W.R., Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain (2000) Free Radical Biology and Medicine, 28 (3), pp. 418-427. , DOI 10.1016/S0891-5849(99)00258-0, PII S0891584999002580
Mieyal, J.J., Gallogly, M.M., Qanungo, S., Sabens, E.A., Shelton, M.D., Molecular mechanisms and clinical implications of reversible protein S-glutathionylation (2008) Antioxid Redox Signal, 10, pp. 1941-1988
Morimoto, R.I., Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging (2008) Genes Dev, 22, pp. 1427-1438
Navarro, A., Boveris, A., The mitochondrial energy transduction system and the aging process (2007) Am J Physiol Cell Physiol, 292, pp. C670-C686
Navarro, A., Lopez-Cepero, J.M., Bandez, M.J., Sanchez-Pino, M.J., Gomez, C., Cadenas, E., Boveris, A., Hippocampal mitochondrial dysfunction in rat aging (2008) Am J Physiol Regul Integr Comp Physiol, 294, pp. R501-R509
Nicoletti, V.G., Santoro, A.M., Grasso, G., Vagliasindi, L.I., Giuffrida, M.L., Cuppari, C., Purrello, V.S., Rizzarelli, E., Carnosine interaction with nitric oxide and astroglial cell protection (2007) J Neurosci Res, 85, pp. 2239-2245
Pegova, A., Abe, H., Boldyrev, A., Hydrolysis of carnosine and related compounds by mammalian carnosinases (2000) Comp Biochem Physiol Biochem Mol Biol, 127, pp. 443-446
Pubill, D., Verdaguer, E., Sureda, F.X., Camins, A., Pallas, M., Camarasa, J., Escubedo, E., Carnosine prevents methamphetamine-induced gliosis but not dopamine terminal loss in rats (2002) Eur J Pharmacol, 448, pp. 165-168
Rizzarelli, E., Vecchio, G., Lazzarino, G., Amorini, A.M., Bellia, F., (2007) Trehalose Conjugate with Carnosine Having Antioxidant Activity, Stable to Enzymic Hydrolysis, Procedure for Its Preparation, and Pharmaceutical, Cosmetic and Nutraceutical Compositions That Contain It, , EU Patent 1860116
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Severina, I.S., Bussygina, O.G., Pyatakova, N.V., Carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 783-788
Shevchenko, A., Wilm, M., Vorm, O., Mann, M., Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels (1996) Anal Chem, 68, pp. 850-858
Snyder, S.H., Brain peptides as neurotransmitters (1980) Science, 209, pp. 976-983
Stvolinsky, S., Kukley, M., Dobrota, D., Mezesova, V., Boldyrev, A., Carnosine protects rats under global ischemia (2000) Brain Res Bull, 53, pp. 445-448
Tang, S.C., Arumugam, T.V., Cutler, R.G., Jo, D.G., Magnus, T., Chan, S.L., Mughal, M.R., Mattson, M.P., Neuroprotective actions of a histidine analogue in models of ischemic stroke (2007) J Neurochem, 101, pp. 729-736
Teufel, M., Saudek, V., Ledig, J.-P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., Sequence identification and characterization of human carnosinase and a closely related nonspecific dipeptidase (2003) J Biol Chem, 278, pp. 6521-6531
Tew, K.D., Redox in redux: Emergent roles for glutathione S-transferase P (GSTP) in regulation of cell signaling and S-glutathionylation (2007) Biochem Pharmacol, 73, pp. 1257-1269
Tomobe, K., Nomura, Y., Neurochemistry, neuropathology, and heredity in SAMP8: A mouse model of senescence (2009) Neurochem Res, 34, pp. 660-669
Unno, H., Yamashita, T., Ujita, S., Okumura, N., Otani, H., Okumura, A., Nagai, K., Kusunoki, M., Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2 (2008) J Biol Chem, 283, pp. 27289-27299
Van Munster, P.J., Trijbels, J.M., Van Heeswijk, P.J., Moerkerk, C., Schut-Jansen, B., A new sensitive method for the determination of serum carnosinase activity using l-carnosine-[I-14C] beta-alanyl as substrate (1970) Clin Chim Acta, 29, pp. 243-248
Yuneva, A.O., Kramarenko, G.G., Vetreshchak, T.V., Gallant, S., Boldyrev, A.A., Effect of carnosine on Drosophila melanogaster lifespan (2002) Bull Exp Biol Med, 133, pp. 559-561
Zeevalk, G.D., Razmpour, R., Bernard, L.P., Glutathione and Parkinson's disease: Is this the elephant in the room? (2008) Biomed Pharmacother, 62, pp. 236-249
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2759-2775.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 7.581, 5-year impact factor: 6.853
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-73449088037&partnerID=40&md5=5ea951d323dac4074fff57266df9d5d3
Keywords: Antibody, Carbonyl Derivative, Carnosinase Cn1, Dipeptidase, Glutathione, Heat Shock Protein 72, Heme Oxygenase 1, Recombinant Enzyme, Thiol Derivative, Thioredoxin, Thioredoxin Reductase, Unclassified Drug, Aminoacyl-Histidine Dipeptidase, Aminoacylhistidine Dipeptidase, Aging, Animal Tissue, Antibody Production, Brain, Brain Cortex, Cell Line, Cellular Stress Response, Cerebellum, Corpus Striatum, Enzyme Activity, Genetic Transfection, Hippocampus, Nitrosative Stress, Nonhuman, Oxidation Reduction Reaction, Oxidative Stress, Priority Journal, Protein Analysis, Purification, Review, Senescence, Septum Nucleus, Substantia Nigra, Article, Enzyme Linked Immunosorbent Assay, Enzymology, Hela Cell, Immunohistochemistry, Mass Spectrometry, Metabolism, Physiology, Polymerase Chain Reaction, Wistar Rat, Enzyme-Linked Immunosorbent Assay, Hsp72 Heat-Shock Proteins, Oxidation-Reduction, Thioredoxin-Disulfide Reductase,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Catania , Catania Section, Catania, Italy.
Institute of Biostructures and Bioimages, CNR, Catania Section, Catania, Italy
National Institute of Biosystems and Biostructures, Catania Section, Catania, Italy
References:
Abdul, H.M., Calabrese, V., Calvani, M., Butterfield, D.A., Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease (2006) J Neurosci Res, 84, pp. 398-40
Amorini, A.M., Bellia, F., Di Pietro, V., Giardina, B., La Mendola, D., Lazzarino, G., Sortino, S., Vecchio, G., Synthesis and antioxidant activity of new homocarnosine b-cyclodextrin conjugates (2007) Eur J Med Chem, 42, pp. 910-920
Balion, C.M., Benson, C., Raina, P.S., Papaioannou, A., Patterson, C., Ismaila, A.S., Brain type carnosinase in dementia: A pilot study (2007) BMC Neurol, 7, p. 38
Bauer, K., Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brain (2005) Neurochem Res, 30, pp. 1339-1345
Bellia, F., Amorini, A.M., La Mendola, D., Vecchio, G., Tavazzi, B., Giardina, B., Di Pietro, V., Rizzarelli, E., New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (2008) Eur J Med Chem, 43, pp. 373-380
Boldyrev, A.A., Severin, S.E., The histidine-containing dipeptides, carnosine and anserine: Distribution, properties and biological significance (1990) Adv Enzyme Regul, 30, pp. 175-194
Boldyrev, A.A., Yuneva, M.O., Sorokina, E.V., Kramarenko, G.G., Fedorova, T.N., Konovalova, G.G., Lankin, V.Z., Antioxidant systems in tissues of senescence accelerated mice (2001) Biochemistry (Mosc), 66, pp. 1157-1163
Butterfield, D.A., Stadtman, E.R., Protein oxidation processes in aging brain (1997) Adv Cell Aging Gerontol, 2, pp. 161-191
Calabrese, V., Butterfield, D.A., Stella, A.M., Aging and oxidative stress response in the CNS (2008) Handbook of Neurochemistry and Molecular Neurobiology, pp. 128-134. , edited by Lajtha A, Perez-Polo JR, Rossner S. New York: Springer
Calabrese, V., Colombrita, C., Guagliano, E., Sapienza, M., Ravagna, A., Cardile, V., Scapagnini, G., Rizzarelli, E., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochem Res, 30, pp. 797-807
Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Calabrese, E.J., Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis (2009) Biofactors, 35, pp. 146-160
Calabrese, V., Guagliano, E., Sapienza, M., Panebianco, M., Calafato, S., Puleo, E., Pennisi, G., Stella, A.G., Redox regulation of cellular stress response in aging and neurodegenerative disorders: Role of vitagenes (2007) Neurochem Res, 32, pp. 757-773
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D.A., Stella, A.M., Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity (2007) Nat Rev Neurosci, 8, pp. 766-775
Calabrese, V., Sultana, R., Scapagnini, G., Guagliano, E., Sapienza, M., Bella, R., Kanski, J., Butterfield, D.A., Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease (2006) Antioxid Redox Signal, 8, pp. 1975-1986
Crush, K.G., Carnosine and related substances in animal tissues (1970) Comp Biochem Physiol, 34, pp. 3-30
De Leon, M.J., George, A.E., Golomb, J., Tarshish, C., Convit, A., Kluger, A., De Santi, S., Wisniewski, H.M., Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease (1997) Neurobiology of Aging, 18 (1), pp. 1-11. , DOI 10.1016/S0197-4580(96)00213-8, PII S0197458096002138
Dobrota, D., Fedorova, T., Stvolinsky, S., Babusikova, E., Likavcanova, K., Drgova, A., Strapkova, A., Boldyrev, A., Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: After-stroke effect (2005) Neurochem Res, 30, pp. 1283-1288
Dukic-Stefanovic, S., Schinzel, R., Riederer, P., Munch, G., AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs? (2001) Biogerontology, 2, pp. 19-34
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cell Mol Life Sci, 59, pp. 546-551
Fu, Q., Dai, H., Hu, W., Fan, Y., Shen, Y., Zhang, W., Chen, Z., Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells (2008) Cell Mol Neurobiol, 28, pp. 307-316
Gerschman, R., Gilbert, D.L., Nye, S.W., Dwyer, P., Fenn, W.O., Oxygen poisoning and x-irradiation: A mechanism in common (1954) Science, 119, pp. 623-626
Gobom, J., Nordhoff, E., Mirgorodskaya, E., Ekman, R., Roepstorff, P., Sample purification and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrix-assisted laser desorption=ionization mass spectrometry (1999) J Mass Spectrom, 34, pp. 105-116
Gruber, J., Schaffer, S., Halliwell, B., The mitochondrial free radical theory of ageing: Where do we stand? (2008) Front Biosci, 13, pp. 6554-6579
Gulewitsch, W., Amiradzibi, S., Carnosine, a new organic base from meat extracts (1900) Ber Dtsch Chem Ges, 33, pp. 1902-1903
Hamm-Alvarez, S., Cadenas, E., Mitochondrial medicine and mitochondrion-based therapeutics (2008) Adv Drug Deliv Rev, 60, pp. 1437-1438
Harman, D., Aging: A theory based on free radical and radiation chemistry (1956) J Gerontol, 11, pp. 298-300
Harman, D., Free radical theory of aging: An update: Increasing the functional life span (2006) Ann N y Acad Sci, 1067, pp. 10-21
Heales, S.J., Bolanos, J.P., Clark, J.B., Glutathione depletion is accompanied by increased neuronal nitric oxide synthase activity (1996) Neurochem Res, 21, pp. 35-39
Hipkiss, A.R., Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptide (2005) Biogerontology, 6, pp. 147-149
Hipkiss, A.R., Glycation, ageing and carnosine: Are carnivorous diets beneficial? (2005) Mech Ageing Dev, 126, pp. 1034-1039
Hipkiss, A.R., On the enigma of carnosine's anti-ageing actions (2009) Exp Gerontol, 44, pp. 237-242
Hipkiss, A.R., Preston, J.E., Himsworth, D.T., Worthington, V.C., Keown, M., Michaelis, J., Lawrence, J., Abbott, N.J., Pluripotent protective effects of carnosine, a naturally occurring dipeptide (1998) Ann N y Acad Sci, 854, pp. 37-53
Huang, Y., Duan, J., Chen, H., Chen, M., Chen, G., Separation and determination of carnosine-related peptides using capillary electrophoresis with laser-induced fluorescence detection (2005) Electrophoresis, 26 (3), pp. 593-599. , DOI 10.1002/elps.200406130
Jackson, M.C., Kucera, C.M., Lenney, J.F., Purification and properties of human serum carnosinase (1991) Clin Chim Acta, 196, pp. 193-205
Jin, C.L., Yang, L.X., Wu, X.H., Li, Q., Ding, M.P., Fan, Y.Y., Zhang, W.P., Chen, Z., Effects of carnosine on amygdaloidkindled seizures in Sprague-Dawley rats (2005) Neuroscience, 135, pp. 939-947
Killiany, R.J., Moss, M.B., Albert, M.S., Sandor, T., Tieman, J., Jolesz, F., Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease (1993) Arch Neurol, 50, pp. 949-954
La Mendola, D., Sortino, S., Vecchio, G., Rizzarelli, E., Synthesis of new carnosine derivatives of b-cyclodextrin and their hydroxyl radical scavenger ability (2002) Helv Chim Acta, 85, pp. 1633-1643
Lam, P.Y., Yin, F., Hamilton, R.T., Boveris, A., Cadenas, E., Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production (2009) Free Radic Res, 43, pp. 431-439
Lenney, J.F., George, R.P., Weiss, A.M., Kucera, C.M., Chan, P.W., Rinzler, G.S., Human serum carnosinase: Characterization, distinction from cellular carnosinase, and activation by cadmium (1982) Clin Chim Acta, 123, pp. 221-231
Lenney, J.F., Peppers, S.C., Kucera-Orallo, C.M., George, R.P., Characterization of human tissue carnosinase (1985) Biochem J, 228, pp. 653-660
Lovell, M.A., Xie, C., Gabbita, S.P., Markesbery, W.R., Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain (2000) Free Radical Biology and Medicine, 28 (3), pp. 418-427. , DOI 10.1016/S0891-5849(99)00258-0, PII S0891584999002580
Mieyal, J.J., Gallogly, M.M., Qanungo, S., Sabens, E.A., Shelton, M.D., Molecular mechanisms and clinical implications of reversible protein S-glutathionylation (2008) Antioxid Redox Signal, 10, pp. 1941-1988
Morimoto, R.I., Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging (2008) Genes Dev, 22, pp. 1427-1438
Navarro, A., Boveris, A., The mitochondrial energy transduction system and the aging process (2007) Am J Physiol Cell Physiol, 292, pp. C670-C686
Navarro, A., Lopez-Cepero, J.M., Bandez, M.J., Sanchez-Pino, M.J., Gomez, C., Cadenas, E., Boveris, A., Hippocampal mitochondrial dysfunction in rat aging (2008) Am J Physiol Regul Integr Comp Physiol, 294, pp. R501-R509
Nicoletti, V.G., Santoro, A.M., Grasso, G., Vagliasindi, L.I., Giuffrida, M.L., Cuppari, C., Purrello, V.S., Rizzarelli, E., Carnosine interaction with nitric oxide and astroglial cell protection (2007) J Neurosci Res, 85, pp. 2239-2245
Pegova, A., Abe, H., Boldyrev, A., Hydrolysis of carnosine and related compounds by mammalian carnosinases (2000) Comp Biochem Physiol Biochem Mol Biol, 127, pp. 443-446
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Carnosinase levels in aging brain: redox state induction and cellular stress response
Carnosinase is a dipeptidase found almost exclusively in brain and serum. Its natural substrate carnosine, present at high concentration in the brain, has been proposed as an antioxidant in vivo. We investigated the role of carnosinase in brain aging to establish a possible correlation with age-related changes in cellular stress response and redox status. In addition, a stable HeLa cell line expressing recombinant human serum carnosinase CN1 was established. The enzyme was purified from transfected cells, and specific antibodies were produced against it. Brain expression of CN1, Hsp72, heme oxygenase-1, and thioredoxin reductase increased with age, with a maximal induction in hippocampus and substantia nigra, followed by cerebellum, cortex, septum, and striatum. Hsps induction was associated with significant changes in total SH groups, GSH redox state, carbonyls, and HNE levels. A positive correlation between decrease in GSH and increase in Hsp72 expression was observed in all brain regions examined during aging. Increased carnosinase activity in the brain can lead to decreased carnosine levels and GSH/GSSG ratio. These results, consistent with the current notion that oxidative stress and cellular damage are characteristic hallmarks of the aging process, sustain the critical role of cellular stress-response mechanisms as possible targets for novel antiaging strategies.
Carnosinase is a dipeptidase found almost exclusively in brain and serum. Its natural substrate carnosine, present at high concentration in the brain, has been proposed as an antioxidant in vivo. We investigated the role of carnosinase in brain aging to establish a possible correlation with age-related changes in cellular stress response and redox status. In addition, a stable HeLa cell line expressing recombinant human serum carnosinase CN1 was established. The enzyme was purified from transfected cells, and specific antibodies were produced against it. Brain expression of CN1, Hsp72, heme oxygenase-1, and thioredoxin reductase increased with age, with a maximal induction in hippocampus and substantia nigra, followed by cerebellum, cortex, septum, and striatum. Hsps induction was associated with significant changes in total SH groups, GSH redox state, carbonyls, and HNE levels. A positive correlation between decrease in GSH and increase in Hsp72 expression was observed in all brain regions examined during aging. Increased carnosinase activity in the brain can lead to decreased carnosine levels and GSH/GSSG ratio. These results, consistent with the current notion that oxidative stress and cellular damage are characteristic hallmarks of the aging process, sustain the critical role of cellular stress-response mechanisms as possible targets for novel antiaging strategies.
Carnosinase levels in aging brain: redox state induction and cellular stress response
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Carnosinase levels in aging brain: redox state induction and cellular stress response
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Impact Factor: 4.784
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Sgarlata C, Arena G, Bonomo RP, Giuffrida A, Tabbì G
* Simple and mixed complexes of copper(II) with 8-hydroxyquinoline derivatives and amino acids: Characterization in solution and potential biological implications (406 views) (PDF 160 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2017 Dec 8; 180: 89-100.
Impact Factor: 3.063
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Pica A, Chi M-C, Chen Y-Y, D'Ischia M, Lin L-L, Merlino A
* The maturation mechanism of γ-glutamyl transpeptidases: Insights from the crystal structure of a precursor mimic of the enzyme from Bacillus licheniformis and from site-directed mutagenesis studies (357 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2016; 1864(2): 195-203.
Impact Factor: 5.476
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Limauro D, De Simone G, Pirone L, Bartolucci S, D'Ambrosio K, Pedone E
* Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase (429 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2014 Mar; 18(2): 219-228.
Impact Factor: 2.306
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Bellia F, Vecchio G, Rizzarelli E
* Carnosinases, Their Substrates And Diseases (660 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2014 Feb 21; 19(2): 2299-2329.
Impact Factor: 2.416
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Bellia F, Oliveri V, Rizzarelli E, Vecchio G
* New derivative of carnosine for nanoparticle assemblies (458 views)
Eur J Med Chem (ISSN: 1768-3254, 0223-5234, 1768-3254electronic), 2013 Dec; 70: 225-232.
Impact Factor: 3.432
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Sica F, Pica A, Merlino A, Russo Krauss I, Ercole C, Picone D
* The multiple forms of bovine seminal ribonuclease: Structure and stability of a C-terminal swapped dimer (328 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013 Nov 29; 587(23): 3755-3762.
Impact Factor: 3.341
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (624 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
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Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A
* The mode of action of anticancer gold-based drugs: a structural perspective (366 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013; 49(86): 10100-10102.
Impact Factor: 6.718
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Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (384 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
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De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (423 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Castellano I, Merlino A
* γ-glutamyltranspeptidases: Sequence, structure, biochemical properties, and biotechnological applications (422 views)
Cell Mol Life Sci (ISSN: 1420-682x), 2012; 69(20): 3381-3394.
Impact Factor: 5.615
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (535 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Merlino A, Russo Krauss I, Albino A, Pica A, Vergara A, Masullo M, De Vendittis E, Sica F
* Improving Protein Crystal Quality by the Without-Oil Microbatch Method: Crystallization and Preliminary X-ray Diffraction Analysis of Glutathione Synthetase from Pseudoalteromonas haloplanktis (361 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2011 Sep; 12(9): 6312-6319.
Impact Factor: 2.598
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (424 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (455 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
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Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (402 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
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Castellano I, Di Salle A, Merlino A, Rossi M, La Cara F
* Gene cloning and protein expression of γ-glutamyltranspeptidases from Thermus thermophilus and Deinococcus radiodurans: Comparison of molecular and structural properties with mesophilic counterparts (340 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2011; 15(2): 259-270.
Impact Factor: 2.941
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Alterio V, Aurilia V, Romanelli A, Parracino A, Saviano M, D'Auria S, De Simone G
* Crystal structure of an S-formylglutathione hydrolase from pseudoalteromonas haloplanktis TAC125 (370 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Sep; 93(8): 669-677.
Impact Factor: 2.572
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Erkekoǧlu P, Rachidi W, De Rosa V, Giray B, Favier A, Hincal F
* Protective effect of selenium supplementation on the genotoxicity of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate treatment in LNCaP cells (554 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2010 Aug 15; 49(4): 559-566.
Impact Factor: 5.707
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (613 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
Impact Factor: 3.787
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Pedone E, Limauro D, Bartolucci S
* The Machinery for Oxidative Protein Folding in Thermophiles (vol 10, pg 157, 2008) (315 views)
Antioxid Redox Signal (ISSN: 1523-0864, 1557-7716, 1523-0864linking), 2010 Jan; 12(1): 157-169.
Impact Factor: 8.209
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Doti N, Marasco D, Pedone C, Sabatella M, Ruvo M
* Optimizing A Kinase Assay For Ikkbeta On An Hts Station (373 views)
J Biomol Screen (ISSN: 1087-0571, 1552-454x, 1552-454xelectronic), 2009 Dec; 14(10): 1263-1268.
Impact Factor: 2.395
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (850 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Limauro D, Saviano M, Galdi I, Rossi M, Bartolucci S, Pedone E
* Sulfolobus solfataricus protein disulphide oxidoreductase: insight into the roles of its redox sites (234 views)
Protein Engineering Design & Selection (ISSN: 1741-0126), 2009 Jan; 22(1): 19-26.
Impact Factor: 2.596
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (444 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
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Pedone E, Limauro D, Bartolucci S
* The machinery for oxidative protein folding in thermophiles (337 views)
Antioxid Redox Signal (ISSN: 1523-0864, 1557-7716, 1523-0864linking), 2008 Jan; 10(1): 157-169.
Impact Factor: 6.19
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (400 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Pedone E, Limauro D, D'Alterio R, Rossi M, Bartolucci S
* Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus (328 views)
Febs Journal (ISSN: 1742-464x), 2006 Dec; 273(23): 5407-5420.
Impact Factor: 3.033
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D'Ambrosio K, Pedone E, Langella E, De Simone G, Rossi M, Pedone C, Bartolucci S
* A novel member of the protein disulfide oxidoreductase family from Aeropyrum pernix K1: Structure, function and electrostatics (475 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2006 Sep 29; 362(4): 743-752.
Impact Factor: 4.89
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Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
* A new spot test for sulfhydryl-containing compounds (450 views)
Anal Biochem, 2006 Mar 14; 79(1-2): 610-611.
Impact Factor: 2.305
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Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
* Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase (723 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 14; 45(10): 3226-3234.
Impact Factor: 3.633
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (587 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 15; 62(3): 604-616.
Impact Factor: 3.73
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Pedone E, D'Ambrosio K, De Simone G, Rossi M, Pedone C, Bartolucci S
* Insights on a new PDI-like family: Structural and functional analysis of a protein disulfide oxidoreductase from the bacterium Aquifex aeolicus (391 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2006 Feb 10; 356(1): 155-164.
Impact Factor: 4.89
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Pedone E, Saviano M, Bartolucci S, Rossi M, Ausili A, Scire A, Bertoli E, Tanfani F
* Temperature-, SDS-, and pH-induced conformational changes in protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: A dynamic simulation and fourier transform infrared spectroscopic study (318 views)
J Proteome Res (ISSN: 1535-3893), 2005 Nov; 4(6): 1972-1980.
Impact Factor: 6.901
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Pedone E, Ren B, Ladenstein R, Rossi M, Bartolucci S
* Functional properties of the protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus - A member of a novel protein family related to protein disulfide-isomerase (390 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 Sep; 271(16): 3437-3448.
Impact Factor: 3.26
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D'Ambrosio K, Kauffmann B, Rouhier N, Benedetti E, Jacquot JP, Aubry A, Corbier C
* Crystallization and preliminary X-ray studies of the glutaredoxin from poplar in complex with glutathione (304 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2003 Jun; 59: 1043-1045.
Impact Factor: 2.208
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Orru S, Vitagliano L, Esposito L, Mazzarella L, Marino G, Ruoppolo M
Effect of deamidation on folding of ribonuclease (385 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Dec; 9(12): 2577-2582.
Impact Factor: 3.869
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Esposito L, Vitagliano L, Zagari A, Mazzarella L
Pyramidalization of backbone carbonyl carbon atoms in proteins (449 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2000 Oct; 9(10): 2038-2042.
Impact Factor: 3.869
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Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (361 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
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Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (351 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates (336 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1997 Apr 25; 272(17): 11147-11151.
Impact Factor: 6.963
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Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (472 views)
Nitric Oxide Biology And Chemistry (ISSN: 1089-8603), 1997 Feb; 1(1): 88-94.
Impact Factor: 2.151
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Wink DA, Grisham MB, Miles AM, Nims RW, Krishna MC, Pacelli R, Teague D, Poore CM, Cook JA, Ford PC
Determination of selectivity of reactive nitrogen oxide species for various substrates (366 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic, 0076-6879linking), 1996; 268: 120-130.
Impact Factor: 2.435
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (526 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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52 Records (52 excluding Abstracts).
Total impact factor: 219.621 (219.621 excluding Abstracts).
Total 5 year impact factor: 228.914 (228.914 excluding Abstracts).
Total impact factor: 219.621 (219.621 excluding Abstracts).
Total 5 year impact factor: 228.914 (228.914 excluding Abstracts).
430 views. Last view on Monday 27 March 2023, 18:40:11
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