Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (429 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
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Paper type: Journal Article,
Impact factor: 2.608, 5-year impact factor: 2.573
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651326306&partnerID=40&md5=84d7cb8162b8caed925c6fd7f3229f8f
Keywords: Astrocytes, Inos, L-Carnosine, Oligodendrocytes, Parp, Trehalose, Gamma Interferon, Inducible Nitric Oxide Synthase, Lactate Dehydrogenase, Lipopolysaccharide, Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1, Animal Cell, Article, Cell Viability, Cellular Stress Response, Controlled Study, Down Regulation, Drug Mechanism, Enzyme Activity, Enzyme Release, Gene Expression Regulation, Nerve Cell Necrosis, Neuroprotection, Nonhuman, Nucleotide Sequence, Oligodendroglia, Oxidative Stress, Phenotype, Polymerase Chain Reaction, Priority Journal, Protein Expression, Western Blotting, Base Sequence, Cultured, Dna Primers, Interferon-Gamma, Poly(adp-Ribose) Polymerases, Rattus, Poly (adp-Ribose) Polymerases,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, University of Catania, Viale A. Doria 6, Catania 95125, Italy
Istituto Biostrutture e Bioimmagini CNR Sez. di Catania, Viale A.Doria 6, Catania 95125, Italy
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Sharp, L.K., Mallya, M., Kinghorn, K.J., Wang, Z., Crowther, D.C., Huntington, J.A., Belorgey, D., Lomas, D.A., Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis (2006) FEBS Journal, 273 (11), pp. 2540-2552. , DOI 10.1111/j.1742-4658.2006.05262.x
Purrello, V.S., Cormaci, G., Denaro, L., Reale, S., Costa, A., Lalicata, C., Sabbatini, M., Avola, R., Effect of growth factors on nuclear and mitochondrial ADP-ribosylation processes during astroglial cell development and aging in culture (2002) Mechanisms of Ageing and Development, 123 (5), pp. 511-520. , DOI 10.1016/S0047-6374(01)00354-2, PII S0047637401003542
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Hassa, P.O., Buerki, C., Lombardi, C., Imhof, R., Hottiger, M.O., Transcriptional Coactivation of Nuclear Factor-κB-dependent Gene Expression by p300 Is Regulated by Poly(ADP)-ribose Polymerase-1 (2003) Journal of Biological Chemistry, 278 (46), pp. 45145-45153. , DOI 10.1074/jbc.M307957200
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Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A., Dawson, V. L., Poly (ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia (1997) Nature Medicine, 3 (10), pp. 1089-1095. , DOI 10. 1038/nm1097-1089
Moroni, F., Poly (ADP-ribose) polymerase 1 (PARP-1) and postischemic brain damage (2008) Current Opinion in Pharmacology, 8 (1), pp. 96-103. , DOI 10. 1016/j. coph. 2007. 10. 005, PII S1471489207001762
Mandir, A. S., Przedborski, S., Jackson-Lewis, V., Wang, Z. -Q., Simbulan- Rosenthal, C. M., Smulson, M. E., Hoffman, B. E., Dawson, T. M., Poly (ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridine (MPTP) -induced Parkinsonism (1999) Proceedings of the National Academy of Sciences of the United States of America, 96 (10), pp. 5774-5779. , DOI 10. 1073/pnas. 96. 10. 5774
Oliver, F. J., Menissier-de Murcia, J., Nacci, C., Decker, P., Andriantsitohaina, R., Muller, S., De La Rubia, G., De Murcia, G., Resistance to endotoxic shock as a consequence of defective NF- B activation in poly (ADP-ribose) polymerase-1 deficient mice (1999) EMBO Journal, 18 (16), pp. 4446-4454. , DOI 10. 1093/emboj/18. 16. 4446
Koh, D. W., Dawson, T. M., Dawson, V. L., Mediation of cell death by poly (ADP-ribose) polymerase-1 (2005) Pharmacological Research, 52 (1 SPEC. ISSUE), pp. 5-14. , DOI 10. 1016/j. phrs. 2005. 02. 011, PII S1043661805000435
Yu, S. -W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, V. L., Mediation of poty (ADP-ribose) polymerase-1 - Dependent cell death by apoptosis-inducing factor (2002) Science, 297 (5579), pp. 259-263. , DOI 10. 1126/science. 1072221
Ame, J. -C., Spenlehauer, C., De Murcia, G., The PARP superfamily (2004) BioEssays, 26 (8), pp. 882-893. , DOI 10. 1002/bies. 20085
Phulwani, N. K., Kielian, T., Poly (ADP-ribose) polymerase s (PARPs) 1-3 regulate astrocyte activation (2008) J Neurochem, 106, pp. 578-590. , 1: CAS: 528: DC%2BD1cXovFWgt7k%3D 10. 1111/j. 1471-4159. 2008. 05403. x 18410506
Ame, J. -C., Rolli, V., Schreiber, V., Niedergang, C., Apiou, F., Decker, P., Muller, S., De Murcia, G., PARP-2, a novel mammalian DNA damage-dependent poly (ADP-ribose) polymerase (1999) Journal of Biological Chemistry, 274 (25), pp. 17860-17868. , DOI 10. 1074/jbc. 274. 25. 17860
Hipkiss, A. R., Brownson, C., Bertani, M. F., Reaction of L-carnosine with aged proteins: Another protective process? (2002) Ann N y Acad Sci, 959, pp. 285-294. , 1: CAS: 528: DC%2BD38XktFWqu74%3D 10. 1111/j. 1749-6632. 2002. tb02100. x 11976203
Hobart, L. J., Seibel, I., Yeargans, G. S., Seidler, N. W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sciences, 75 (11), pp. 1379-1389. , DOI 10. 1016/j. lfs. 2004. 05. 002, PII S0024320504004151
B ranger, F., Crozet, C., Goldsborough, A., Trehalose impairs aggregation of PrPSc molecules and protects prion-infected cells against oxidative damage (2008) Biochem Biophys Res Commun, 374, pp. 44-48. , 10. 1016/j. bbrc. 2008. 06. 094 18602368
Sharp, L. K., Mallya, M., Kinghorn, K. J., Wang, Z., Crowther, D. C., Huntington, J. A., Belorgey, D., Lomas, D. A., Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis (2006) FEBS Journal, 273 (11), pp. 2540-2552. , DOI 10. 1111/j. 1742-4658. 2006. 05262. x
Purrello, V. S., Cormaci, G., Denaro, L., Reale, S., Costa, A., Lalicata, C., Sabbatini, M., Avola, R., Effect of growth factors on nuclear and mitochondrial ADP-ribosylation processes during astroglial cell development and aging in culture (2002) Mechanisms of Ageing and Development, 123 (5), pp. 511-520. , DOI 10. 1016/S0047-6374 (01) 00354-2, PII S0047637401003542
McCarthy, K. D., De Vellis, J., Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue (1980) Journal of Cell Biology, 85 (3), pp. 890-902. , DOI 10. 1083/jcb. 85. 3. 890
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Protein measurement with the Folin phenol reagent (1951) J Biol Chem, 193, pp. 265-275. , 1: CAS: 528: DyaG38XhsVyrsw%3D%3D 14907713
Nicoletti, V. G., Santoro, A. M., Grasso, G., Vagliasindi, L. I., Giuffrida, M. L., Cuppari, C., Purrello, V. S., Rizzarelli, E., Carnosine interaction with nitric oxide and astroglial cell protection (2007) Journal of Neuroscience Research, 85 (10), pp. 2239-2245. , DOI 10. 1002/jnr. 21365
Ha, H. C., Snyder, S. H., Poly (ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion (1999) Proc Natl Acad Sci USA, 96, pp. 13782-13978
Alano, C. C., Ying, W., Swanson, R. A., Poly (ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD + Depletion and Mitochondrial Permeability Transition (2004) Journal of Biological Chemistry, 279 (18), pp. 18895-18902. , DOI 10. 1074/jbc. M313329200
Hassa, P. O., Hottiger, M. O., The functional role of poly (ADP-ribose) polymerase 1 as novel coactivator of NF- B in inflammatory disorders (2002) Cellular and Molecular Life Sciences, 59 (9), pp. 1534-1553. , DOI 10. 1007/s00018-002-8527-2
Severina, I. S., Bussygina, O. G., Pyatakova, N. V., L-carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 783-788. , 1: CAS: 528: DC%2BD3cXlvFOlsbo%3D
Mcfarland, G. A., Holliday, R., Retardation of the senescence of cultured human diploid fibroblasts by carnosine (1994) Experimental Cell Research, 212 (2), pp. 167-175. , DOI 10. 1006/excr. 1994. 1132
Hipkiss, A. R., L-carnosine and its possible roles in nutrition and health (2009) Adv Food Nutr Res, 57, pp. 87-154. , 1: CAS: 528: DC%2BC3cXmt1Ohuw%3D%3D 10. 1016/S1043-4526 (09) 57003-9 19595386
Mabley, J. G., Jagtap, P., Perretti, M., Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase (2001) Inflamm Res, 50, pp. 561-569. , 1: CAS: 528: DC%2BD3MXos12msLs%3D 10. 1007/PL00000234 11766996
Hassa, P. O., Buerki, C., Lombardi, C., Imhof, R., Hottiger, M. O., Transcriptional Coactivation of Nuclear Factor- B-dependent Gene Expression by p300 Is Regulated by Poly (ADP) -ribose Polymerase-1 (2003) Journal of Biological Chemistry, 278 (46), pp. 45145-45153. , DOI 10. 1074/jbc. M307957200
Hassa, P. O., Haenni, S. S., Buerki, C., Meier, N. I., Lane, W. S., Owen, H., Gersbach, M., Hottiger, M. O., Acetylation of poly (ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF- B-dependent transcription (2005) Journal of Biological Chemistry, 280 (49), pp. 40450-40464. , DOI 10. 1074/jbc. M507553200
Scott, G. S., Virag, L., Szabo, C., Hooper, D. C., Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly (ADP-ribose) polymerase activation (2003) GLIA, 41 (2), pp. 105-116. , DOI 10. 1002/glia. 10137
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
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Paper type: Journal Article,
Impact factor: 2.608, 5-year impact factor: 2.573
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651326306&partnerID=40&md5=84d7cb8162b8caed925c6fd7f3229f8f
Keywords: Astrocytes, Inos, L-Carnosine, Oligodendrocytes, Parp, Trehalose, Gamma Interferon, Inducible Nitric Oxide Synthase, Lactate Dehydrogenase, Lipopolysaccharide, Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1, Animal Cell, Article, Cell Viability, Cellular Stress Response, Controlled Study, Down Regulation, Drug Mechanism, Enzyme Activity, Enzyme Release, Gene Expression Regulation, Nerve Cell Necrosis, Neuroprotection, Nonhuman, Nucleotide Sequence, Oligodendroglia, Oxidative Stress, Phenotype, Polymerase Chain Reaction, Priority Journal, Protein Expression, Western Blotting, Base Sequence, Cultured, Dna Primers, Interferon-Gamma, Poly(adp-Ribose) Polymerases, Rattus, Poly (adp-Ribose) Polymerases,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, University of Catania, Viale A. Doria 6, Catania 95125, Italy
Istituto Biostrutture e Bioimmagini CNR Sez. di Catania, Viale A.Doria 6, Catania 95125, Italy
References:
Menissier De Murcia, J., Niedergang, C., Trucco, C., Ricoul, M., Dutrillaux, B., Mark, M., Oliver, F.J., De Murcia, G., Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells (1997) Proceedings of the National Academy of Sciences of the United States of America, 94 (14), pp. 7303-7307. , DOI 10.1073/pnas.94.14.730
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Hassa, P.O., Buerki, C., Lombardi, C., Imhof, R., Hottiger, M.O., Transcriptional Coactivation of Nuclear Factor-κB-dependent Gene Expression by p300 Is Regulated by Poly(ADP)-ribose Polymerase-1 (2003) Journal of Biological Chemistry, 278 (46), pp. 45145-45153. , DOI 10.1074/jbc.M307957200
Hassa, P.O., Haenni, S.S., Buerki, C., Meier, N.I., Lane, W.S., Owen, H., Gersbach, M., Hottiger, M.O., Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-κB-dependent transcription (2005) Journal of Biological Chemistry, 280 (49), pp. 40450-40464. , DOI 10.1074/jbc.M507553200
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Schreiber, V., Ame, J.-C., Dolle, P., Schultz, I., Rinaldi, B., Fraulob, V., Menissier-de Murcia, J., De Murcia, G., Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1 (2002) Journal of Biological Chemistry, 277 (25), pp. 23028-23036. , DOI 10.1074/jbc.M202390200
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Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A., Dawson, V. L., Poly (ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia (1997) Nature Medicine, 3 (10), pp. 1089-1095. , DOI 10. 1038/nm1097-1089
Moroni, F., Poly (ADP-ribose) polymerase 1 (PARP-1) and postischemic brain damage (2008) Current Opinion in Pharmacology, 8 (1), pp. 96-103. , DOI 10. 1016/j. coph. 2007. 10. 005, PII S1471489207001762
Mandir, A. S., Przedborski, S., Jackson-Lewis, V., Wang, Z. -Q., Simbulan- Rosenthal, C. M., Smulson, M. E., Hoffman, B. E., Dawson, T. M., Poly (ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridine (MPTP) -induced Parkinsonism (1999) Proceedings of the National Academy of Sciences of the United States of America, 96 (10), pp. 5774-5779. , DOI 10. 1073/pnas. 96. 10. 5774
Oliver, F. J., Menissier-de Murcia, J., Nacci, C., Decker, P., Andriantsitohaina, R., Muller, S., De La Rubia, G., De Murcia, G., Resistance to endotoxic shock as a consequence of defective NF- B activation in poly (ADP-ribose) polymerase-1 deficient mice (1999) EMBO Journal, 18 (16), pp. 4446-4454. , DOI 10. 1093/emboj/18. 16. 4446
Koh, D. W., Dawson, T. M., Dawson, V. L., Mediation of cell death by poly (ADP-ribose) polymerase-1 (2005) Pharmacological Research, 52 (1 SPEC. ISSUE), pp. 5-14. , DOI 10. 1016/j. phrs. 2005. 02. 011, PII S1043661805000435
Yu, S. -W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, V. L., Mediation of poty (ADP-ribose) polymerase-1 - Dependent cell death by apoptosis-inducing factor (2002) Science, 297 (5579), pp. 259-263. , DOI 10. 1126/science. 1072221
Ame, J. -C., Spenlehauer, C., De Murcia, G., The PARP superfamily (2004) BioEssays, 26 (8), pp. 882-893. , DOI 10. 1002/bies. 20085
Phulwani, N. K., Kielian, T., Poly (ADP-ribose) polymerase s (PARPs) 1-3 regulate astrocyte activation (2008) J Neurochem, 106, pp. 578-590. , 1: CAS: 528: DC%2BD1cXovFWgt7k%3D 10. 1111/j. 1471-4159. 2008. 05403. x 18410506
Ame, J. -C., Rolli, V., Schreiber, V., Niedergang, C., Apiou, F., Decker, P., Muller, S., De Murcia, G., PARP-2, a novel mammalian DNA damage-dependent poly (ADP-ribose) polymerase (1999) Journal of Biological Chemistry, 274 (25), pp. 17860-17868. , DOI 10. 1074/jbc. 274. 25. 17860
Hipkiss, A. R., Brownson, C., Bertani, M. F., Reaction of L-carnosine with aged proteins: Another protective process? (2002) Ann N y Acad Sci, 959, pp. 285-294. , 1: CAS: 528: DC%2BD38XktFWqu74%3D 10. 1111/j. 1749-6632. 2002. tb02100. x 11976203
Hobart, L. J., Seibel, I., Yeargans, G. S., Seidler, N. W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sciences, 75 (11), pp. 1379-1389. , DOI 10. 1016/j. lfs. 2004. 05. 002, PII S0024320504004151
B ranger, F., Crozet, C., Goldsborough, A., Trehalose impairs aggregation of PrPSc molecules and protects prion-infected cells against oxidative damage (2008) Biochem Biophys Res Commun, 374, pp. 44-48. , 10. 1016/j. bbrc. 2008. 06. 094 18602368
Sharp, L. K., Mallya, M., Kinghorn, K. J., Wang, Z., Crowther, D. C., Huntington, J. A., Belorgey, D., Lomas, D. A., Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis (2006) FEBS Journal, 273 (11), pp. 2540-2552. , DOI 10. 1111/j. 1742-4658. 2006. 05262. x
Purrello, V. S., Cormaci, G., Denaro, L., Reale, S., Costa, A., Lalicata, C., Sabbatini, M., Avola, R., Effect of growth factors on nuclear and mitochondrial ADP-ribosylation processes during astroglial cell development and aging in culture (2002) Mechanisms of Ageing and Development, 123 (5), pp. 511-520. , DOI 10. 1016/S0047-6374 (01) 00354-2, PII S0047637401003542
McCarthy, K. D., De Vellis, J., Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue (1980) Journal of Cell Biology, 85 (3), pp. 890-902. , DOI 10. 1083/jcb. 85. 3. 890
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Protein measurement with the Folin phenol reagent (1951) J Biol Chem, 193, pp. 265-275. , 1: CAS: 528: DyaG38XhsVyrsw%3D%3D 14907713
Nicoletti, V. G., Santoro, A. M., Grasso, G., Vagliasindi, L. I., Giuffrida, M. L., Cuppari, C., Purrello, V. S., Rizzarelli, E., Carnosine interaction with nitric oxide and astroglial cell protection (2007) Journal of Neuroscience Research, 85 (10), pp. 2239-2245. , DOI 10. 1002/jnr. 21365
Ha, H. C., Snyder, S. H., Poly (ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion (1999) Proc Natl Acad Sci USA, 96, pp. 13782-13978
Alano, C. C., Ying, W., Swanson, R. A., Poly (ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD + Depletion and Mitochondrial Permeability Transition (2004) Journal of Biological Chemistry, 279 (18), pp. 18895-18902. , DOI 10. 1074/jbc. M313329200
Hassa, P. O., Hottiger, M. O., The functional role of poly (ADP-ribose) polymerase 1 as novel coactivator of NF- B in inflammatory disorders (2002) Cellular and Molecular Life Sciences, 59 (9), pp. 1534-1553. , DOI 10. 1007/s00018-002-8527-2
Severina, I. S., Bussygina, O. G., Pyatakova, N. V., L-carnosine as a regulator of soluble guanylate cyclase (2000) Biochemistry (Mosc), 65, pp. 783-788. , 1: CAS: 528: DC%2BD3cXlvFOlsbo%3D
Mcfarland, G. A., Holliday, R., Retardation of the senescence of cultured human diploid fibroblasts by carnosine (1994) Experimental Cell Research, 212 (2), pp. 167-175. , DOI 10. 1006/excr. 1994. 1132
Hipkiss, A. R., L-carnosine and its possible roles in nutrition and health (2009) Adv Food Nutr Res, 57, pp. 87-154. , 1: CAS: 528: DC%2BC3cXmt1Ohuw%3D%3D 10. 1016/S1043-4526 (09) 57003-9 19595386
Mabley, J. G., Jagtap, P., Perretti, M., Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase (2001) Inflamm Res, 50, pp. 561-569. , 1: CAS: 528: DC%2BD3MXos12msLs%3D 10. 1007/PL00000234 11766996
Hassa, P. O., Buerki, C., Lombardi, C., Imhof, R., Hottiger, M. O., Transcriptional Coactivation of Nuclear Factor- B-dependent Gene Expression by p300 Is Regulated by Poly (ADP) -ribose Polymerase-1 (2003) Journal of Biological Chemistry, 278 (46), pp. 45145-45153. , DOI 10. 1074/jbc. M307957200
Hassa, P. O., Haenni, S. S., Buerki, C., Meier, N. I., Lane, W. S., Owen, H., Gersbach, M., Hottiger, M. O., Acetylation of poly (ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF- B-dependent transcription (2005) Journal of Biological Chemistry, 280 (49), pp. 40450-40464. , DOI 10. 1074/jbc. M507553200
Scott, G. S., Virag, L., Szabo, C., Hooper, D. C., Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly (ADP-ribose) polymerase activation (2003) GLIA, 41 (2), pp. 105-116. , DOI 10. 1002/glia. 10137
Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress
Poly(ADP-ribose) polymerases (PARPs) play a crucial role in DNA damage surveillance through their nick sensor functions. Since PARPs' over activation leads to an excessive consumption of NAD + and ATP depletion, these enzymes also are involved in the early events of programmed cell death as well as in necrosis. In order to verify the protective action of L-carnosine and trehalose against NO induced cell death, in the present study we examined their effects on the expression of PARP-1, PARP-2 and iNOS in primary rat astrocyte and oligodendrocyte cells, treated with lipopolysaccharide (LPS) and interferon gamma (INFγ), through semi-quantitative PCR and western analysis. To further characterize the molecular mechanisms underlying L-carnosine and trehalose action, we measured cell viability, nitrite production and LDH release. The data obtained clearly demonstrate that in the stress model employed L-carnosine and trehalose down regulate PARP-1 and PARP-2 expression in both cell phenotypes, thus suggesting their possible application in clinical trials. © 2010 Springer Science+Business Media, LLC.
Poly(ADP-ribose) polymerases (PARPs) play a crucial role in DNA damage surveillance through their nick sensor functions. Since PARPs' over activation leads to an excessive consumption of NAD + and ATP depletion, these enzymes also are involved in the early events of programmed cell death as well as in necrosis. In order to verify the protective action of L-carnosine and trehalose against NO induced cell death, in the present study we examined their effects on the expression of PARP-1, PARP-2 and iNOS in primary rat astrocyte and oligodendrocyte cells, treated with lipopolysaccharide (LPS) and interferon gamma (INFγ), through semi-quantitative PCR and western analysis. To further characterize the molecular mechanisms underlying L-carnosine and trehalose action, we measured cell viability, nitrite production and LDH release. The data obtained clearly demonstrate that in the stress model employed L-carnosine and trehalose down regulate PARP-1 and PARP-2 expression in both cell phenotypes, thus suggesting their possible application in clinical trials. © 2010 Springer Science+Business Media, LLC.
Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress
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Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (606 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
* NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (675 views)
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Impact Factor: 3.129
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (831 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (753 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (648 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (575 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (471 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Electrospray mass spectrometric studies of L-carnosine (β-alanyl-L-histidine) complexes with copper(II) or zinc ions in aqueous solution (372 views)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic, 0951-4198linking), 2002; 16(7): 722-729.
Impact Factor: 2.372
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (688 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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* A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells (588 views)
Proteomics (ISSN: 1615-9853), 2015 Feb; 15(4): 714-724.
Impact Factor: 4.079
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (768 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (584 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (422 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Doti N, Scognamiglio PL, Madonna S, Scarponi C, Ruvo M, Perretta G, Albanesi C, Marasco D
* New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (996 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Impact Factor: 4.779
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (535 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (606 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
* NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (675 views)
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Impact Factor: 3.129
View Export to BibTeX Export to EndNote
Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (831 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
View Export to BibTeX Export to EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (753 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
View Export to BibTeX Export to EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (648 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (575 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (471 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
View Export to BibTeX Export to EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Electrospray mass spectrometric studies of L-carnosine (β-alanyl-L-histidine) complexes with copper(II) or zinc ions in aqueous solution (372 views)
Rapid Commun Mass Sp (ISSN: 0951-4198, 1097-0231electronic, 0951-4198linking), 2002; 16(7): 722-729.
Impact Factor: 2.372
View Export to BibTeX Export to EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (688 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
View Export to BibTeX Export to EndNote
18 Records (16 excluding Abstracts).
Total impact factor: 91.012 (86.798 excluding Abstracts).
Total 5 year impact factor: 92.852 (88.594 excluding Abstracts).
Total impact factor: 91.012 (86.798 excluding Abstracts).
Total 5 year impact factor: 92.852 (88.594 excluding Abstracts).
429 views. Last view on Wednesday 22 March 2023, 17:02:22
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