Administration of carnosine in the treatment of acute spinal cord injury (603 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.705, 5-year impact factor: 4.748
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80054715568&partnerID=40&md5=801086ffe396ffd3363214204033acc6
Keywords: Apoptosis, Carnosine, Inflammation, Spinal Cord Injury, 3 Nitrotyrosine, Cytokine, Fas Ligand, Heat Shock Protein 70, Inducible Nitric Oxide Synthase, Myeloperoxidase, Protein Bax, Protein Bcl 2, Fas Antigen, Protein S100b, Aneurysm Clip, Animal Experiment, Animal Model, Animal Tissue, Conference Paper, Controlled Study, Drug Efficacy, Enzyme Activity, Immunoreactivity, Laminectomy, Mouse, Myelitis, Neutrophil Chemotaxis, Nick End Labeling, Nonhuman, Priority Journal, Protein Expression, Tissue Injury, Immunohistochemistry, Injury Severity, Spinal Cord Compression, Staining, Western Blotting, Bcl-2-Associated X Protein, Dose-Response Relationship, Fas Ligand Protein, Gene Expression Regulation, Proto-Oncogene Proteins C-Bcl-2, Spinal Cord Injuries,
Affiliations:
*** IBB - CNR ***
IRCCS Centro Neurolesi Bonino-Pulejo, Via Palermo C.Da Casazza, 98100 Messina, Italy. dipaolar@unime.it
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, via C. Valeria (Gazzi), 98125 Messina, Italy
Department of Chemical Sciences, University of Catania, Viale Andrea Doria, 6, 95125 Catania, Italy
Interuniversity Consortium INBB, Catania, Italy
References:
Ambrozaitis, K.V., Kontautas, E., Spakauskas, B., Vaitkaitis, D., Pathophysiology of acute spinal cord injury (2006) Medicina (Kaunas, Lithuania), 42, pp. 255-26
Calabrese, V., Cornelius, C., Maiolino, L., Luca, M., Chiaramonte, R., Toscano, M.A., Oxidative stress, redox homeostasis and cellular stress response in Meniere's disease: Role of vitagenes (2010) Neurochem Res, 35 (12), pp. 2208-2217
Carlson, G.D., Gorden, C., Current developments in spinal cord injury research (2002) Spine J, 2, pp. 116-128
Cuzzocrea, S., Riley, D.P., Caputi, A.P., Salvemini, D., Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury (2001) Pharmacological Reviews, 53 (1), pp. 135-159
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D.A., Giuffrida Stella, A.M., Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity (2007) Nature Reviews Neuroscience, 8 (10), pp. 766-775. , DOI 10.1038/nrn2214, PII NRN2214
Calabrese, E.J., Mattson, M.P., Calabrese, V., Resveratrol commonly displays hormesis: Occurrence and biomedical significance (2010) Hum Exp Toxicol, 29 (12), pp. 980-1015
Genovese, T., Mazzon, E., Di Paola, R., Crisafulli, C., Muia, C., Bramanti, P., Cuzzocrea, S., Increased oxidative-related mechanisms in the spinal cord injury in old rats (2006) Neuroscience Letters, 393 (2-3), pp. 141-146. , DOI 10.1016/j.neulet.2005.09.060, PII S0304394005011092
Perluigi, M., Di Domenico, F., Giorgi, A., Schinina, M.E., Coccia, R., Cini, C., Redox proteomics in aging rat brain: Involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process (2010) J Neurosci Res, 88 (16), pp. 3498-3507
Kang, J.H., Protective effects of carnosine and homocarnosine on ferritin and hydrogen peroxide-mediated DNA damage (2010) BMB Rep, 43 (10), pp. 683-687
Quinn, P.J., Boldyrev, A.A., Formazuyk, V.E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Molecular Aspects of Medicine, 13 (5), pp. 379-444. , DOI 10.1016/0098-2997(92)90006-L
Hipkiss, A.R., Carnosine and its possible roles in nutrition and health (2009) Adv Food Nutr Res, 57, pp. 87-154
Corona, C., Frazzini, V., Silvestri, E., Lattanzio, R., La Sorda, R., Piantelli, M., Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (2011) PloS One, 6 (3), p. 17971
Shen, Y., He, P., Fan, Y.Y., Zhang, J.X., Yan, H.J., Hu, W.W., Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity (2010) Free Radic Biol Med, 48 (5), pp. 727-735
Calabrese, V., Colombrita, C., Guagliano, E., Sapienza, M., Ravagna, A., Cardile, V., Scapagnini, G., Rizzarelli, E., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochemical Research, 30 (6-7), pp. 797-807. , DOI 10.1007/s11064-005-6874-8
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cellular and Molecular Life Sciences, 59 (3), pp. 546-551. , DOI 10.1007/s00018-002-8446-2
Nicoletti, V.G., Santoro, A.M., Grasso, G., Vagliasindi, L.I., Giuffrida, M.L., Cuppari, C., Purrello, V.S., Rizzarelli, E., Carnosine interaction with nitric oxide and astroglial cell protection (2007) Journal of Neuroscience Research, 85 (10), pp. 2239-2245. , DOI 10.1002/jnr.21365
Teufel, M., Saudek, V., Ledig, J.-P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase (2003) Journal of Biological Chemistry, 278 (8), pp. 6521-6531. , DOI 10.1074/jbc.M209764200
Bellia, F., Calabrese, V., Guarino, F., Cavallaro, M., Cornelius, C., De Pinto, V., Carnosinase levels in aging brain: Redox state induction and cellular stress response (2009) Antioxid Redox Signal, 11, pp. 2759-2775
Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H., Protection of neuronal cells against reactive oxygen species by carnosine and related compounds (2004) Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 137 (1), pp. 81-88. , DOI 10.1016/j.cbpc.2003.10.008
Lanza, V., Bellia, F., D'Agata, R., Grasso, G., Rizzarelli, E., Vecchio, G., New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: Synthesis and characterization of their copper(II) complexes (2011) J Inorg Biochem, 105 (2), pp. 181-188
Bellia, F., Amorini, A.M., La Mendola, D., Vecchio, G., Tavazzi, B., Giardina, B., Di Pietro, V., Rizzarelli, E., New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (2008) European Journal of Medicinal Chemistry, 43 (2), pp. 373-380. , DOI 10.1016/j.ejmech.2007.03.038, PII S0223523407001936
Bertinaria, M., Rolando, B., Giorgis, M., Montanaro, G., Guglielmo, S., Buonsanti, M.F., Synthesis, physicochemical characterization, and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents (2011) J Med Chem, 54 (2), pp. 611-621
Aldini, G., Canevotti, R., Negrisoli, G., (2005) Compositions Containing D-carnosine, , Patent WO 2005/120543
Sirin, B.H., Ortac, R., Cerrahoglu, M., Saribulbul, O., Baltalarli, A., Celebisoy, N., Ischaemic preconditioning reduces spinal cord injury in transient ischaemia (2002) Acta Cardiol, 57, pp. 279-285
Mullane, K., Neutrophil-platelet interactions and post-ischemic myocardial injury (1989) Prog Clin Biol Res, 301, pp. 39-51
Bethea, J.R., Castro, M., Keane, R.W., Lee, T.T., Dietrich, W.D., Yezierski, R.P., Traumatic spinal cord injury induces nuclear factor-κB activation (1998) Journal of Neuroscience, 18 (9), pp. 3251-3260
Basso, D.M., Fisher, L.C., Anderson, A.J., Jakeman, L.B., McTigue, D.M., Popovich, P.G., Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains (2006) Journal of Neurotrauma, 23 (5), pp. 635-659
Hobart, L.J., Seibel, I., Yeargans, G.S., Seidler, N.W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sciences, 75 (11), pp. 1379-1389. , DOI 10.1016/j.lfs.2004.05.002, PII S0024320504004151
Chez, M.G., Buchanan, C.P., Aimonovitch, M.C., Becker, M., Schaefer, K., Black, C., Komen, J., Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders (2002) Journal of Child Neurology, 17 (11), pp. 833-837
Stvolinsky, S.L., Kukley, M.L., Dobrota, D., Matejovicova, M., Tkac, I., Boldyrev, A.A., Carnosine: An endogenous neuroprotector in the ischemic brain (1999) Cellular and Molecular Neurobiology, 19 (1), pp. 45-56. , DOI 10.1023/A:1006960407008
Kang, J.H., Kim, K.S., Enhanced oligomerization of the α-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system (2003) Molecules and Cells, 15 (1), pp. 87-93
Thiel, R., Fowkes, S.W., Can cognitive deterioration associated with Down syndrome be reduced? (2005) Medical Hypotheses, 64 (3), pp. 524-532. , DOI 10.1016/j.mehy.2004.08.020, PII S0306987704004979
Petroff, O.A.C., Hyder, F., Rothman, D.L., Mattson, R.H., Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures (2001) Neurology, 56 (6), pp. 709-715
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Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.705, 5-year impact factor: 4.748
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80054715568&partnerID=40&md5=801086ffe396ffd3363214204033acc6
Keywords: Apoptosis, Carnosine, Inflammation, Spinal Cord Injury, 3 Nitrotyrosine, Cytokine, Fas Ligand, Heat Shock Protein 70, Inducible Nitric Oxide Synthase, Myeloperoxidase, Protein Bax, Protein Bcl 2, Fas Antigen, Protein S100b, Aneurysm Clip, Animal Experiment, Animal Model, Animal Tissue, Conference Paper, Controlled Study, Drug Efficacy, Enzyme Activity, Immunoreactivity, Laminectomy, Mouse, Myelitis, Neutrophil Chemotaxis, Nick End Labeling, Nonhuman, Priority Journal, Protein Expression, Tissue Injury, Immunohistochemistry, Injury Severity, Spinal Cord Compression, Staining, Western Blotting, Bcl-2-Associated X Protein, Dose-Response Relationship, Fas Ligand Protein, Gene Expression Regulation, Proto-Oncogene Proteins C-Bcl-2, Spinal Cord Injuries,
Affiliations:
*** IBB - CNR ***
IRCCS Centro Neurolesi Bonino-Pulejo, Via Palermo C.Da Casazza, 98100 Messina, Italy. dipaolar@unime.it
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, via C. Valeria (Gazzi), 98125 Messina, Italy
Department of Chemical Sciences, University of Catania, Viale Andrea Doria, 6, 95125 Catania, Italy
Interuniversity Consortium INBB, Catania, Italy
References:
Ambrozaitis, K.V., Kontautas, E., Spakauskas, B., Vaitkaitis, D., Pathophysiology of acute spinal cord injury (2006) Medicina (Kaunas, Lithuania), 42, pp. 255-26
Calabrese, V., Cornelius, C., Maiolino, L., Luca, M., Chiaramonte, R., Toscano, M.A., Oxidative stress, redox homeostasis and cellular stress response in Meniere's disease: Role of vitagenes (2010) Neurochem Res, 35 (12), pp. 2208-2217
Carlson, G.D., Gorden, C., Current developments in spinal cord injury research (2002) Spine J, 2, pp. 116-128
Cuzzocrea, S., Riley, D.P., Caputi, A.P., Salvemini, D., Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury (2001) Pharmacological Reviews, 53 (1), pp. 135-159
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D.A., Giuffrida Stella, A.M., Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity (2007) Nature Reviews Neuroscience, 8 (10), pp. 766-775. , DOI 10.1038/nrn2214, PII NRN2214
Calabrese, E.J., Mattson, M.P., Calabrese, V., Resveratrol commonly displays hormesis: Occurrence and biomedical significance (2010) Hum Exp Toxicol, 29 (12), pp. 980-1015
Genovese, T., Mazzon, E., Di Paola, R., Crisafulli, C., Muia, C., Bramanti, P., Cuzzocrea, S., Increased oxidative-related mechanisms in the spinal cord injury in old rats (2006) Neuroscience Letters, 393 (2-3), pp. 141-146. , DOI 10.1016/j.neulet.2005.09.060, PII S0304394005011092
Perluigi, M., Di Domenico, F., Giorgi, A., Schinina, M.E., Coccia, R., Cini, C., Redox proteomics in aging rat brain: Involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process (2010) J Neurosci Res, 88 (16), pp. 3498-3507
Kang, J.H., Protective effects of carnosine and homocarnosine on ferritin and hydrogen peroxide-mediated DNA damage (2010) BMB Rep, 43 (10), pp. 683-687
Quinn, P.J., Boldyrev, A.A., Formazuyk, V.E., Carnosine: Its properties, functions and potential therapeutic applications (1992) Molecular Aspects of Medicine, 13 (5), pp. 379-444. , DOI 10.1016/0098-2997(92)90006-L
Hipkiss, A.R., Carnosine and its possible roles in nutrition and health (2009) Adv Food Nutr Res, 57, pp. 87-154
Corona, C., Frazzini, V., Silvestri, E., Lattanzio, R., La Sorda, R., Piantelli, M., Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (2011) PloS One, 6 (3), p. 17971
Shen, Y., He, P., Fan, Y.Y., Zhang, J.X., Yan, H.J., Hu, W.W., Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity (2010) Free Radic Biol Med, 48 (5), pp. 727-735
Calabrese, V., Colombrita, C., Guagliano, E., Sapienza, M., Ravagna, A., Cardile, V., Scapagnini, G., Rizzarelli, E., Protective effect of carnosine during nitrosative stress in astroglial cell cultures (2005) Neurochemical Research, 30 (6-7), pp. 797-807. , DOI 10.1007/s11064-005-6874-8
Fontana, M., Pinnen, F., Lucente, G., Pecci, L., Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides (2002) Cellular and Molecular Life Sciences, 59 (3), pp. 546-551. , DOI 10.1007/s00018-002-8446-2
Nicoletti, V.G., Santoro, A.M., Grasso, G., Vagliasindi, L.I., Giuffrida, M.L., Cuppari, C., Purrello, V.S., Rizzarelli, E., Carnosine interaction with nitric oxide and astroglial cell protection (2007) Journal of Neuroscience Research, 85 (10), pp. 2239-2245. , DOI 10.1002/jnr.21365
Teufel, M., Saudek, V., Ledig, J.-P., Bernhardt, A., Boularand, S., Carreau, A., Cairns, N.J., Smirnova, T., Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase (2003) Journal of Biological Chemistry, 278 (8), pp. 6521-6531. , DOI 10.1074/jbc.M209764200
Bellia, F., Calabrese, V., Guarino, F., Cavallaro, M., Cornelius, C., De Pinto, V., Carnosinase levels in aging brain: Redox state induction and cellular stress response (2009) Antioxid Redox Signal, 11, pp. 2759-2775
Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H., Protection of neuronal cells against reactive oxygen species by carnosine and related compounds (2004) Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 137 (1), pp. 81-88. , DOI 10.1016/j.cbpc.2003.10.008
Lanza, V., Bellia, F., D'Agata, R., Grasso, G., Rizzarelli, E., Vecchio, G., New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: Synthesis and characterization of their copper(II) complexes (2011) J Inorg Biochem, 105 (2), pp. 181-188
Bellia, F., Amorini, A.M., La Mendola, D., Vecchio, G., Tavazzi, B., Giardina, B., Di Pietro, V., Rizzarelli, E., New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (2008) European Journal of Medicinal Chemistry, 43 (2), pp. 373-380. , DOI 10.1016/j.ejmech.2007.03.038, PII S0223523407001936
Bertinaria, M., Rolando, B., Giorgis, M., Montanaro, G., Guglielmo, S., Buonsanti, M.F., Synthesis, physicochemical characterization, and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents (2011) J Med Chem, 54 (2), pp. 611-621
Aldini, G., Canevotti, R., Negrisoli, G., (2005) Compositions Containing D-carnosine, , Patent WO 2005/120543
Sirin, B.H., Ortac, R., Cerrahoglu, M., Saribulbul, O., Baltalarli, A., Celebisoy, N., Ischaemic preconditioning reduces spinal cord injury in transient ischaemia (2002) Acta Cardiol, 57, pp. 279-285
Mullane, K., Neutrophil-platelet interactions and post-ischemic myocardial injury (1989) Prog Clin Biol Res, 301, pp. 39-51
Bethea, J.R., Castro, M., Keane, R.W., Lee, T.T., Dietrich, W.D., Yezierski, R.P., Traumatic spinal cord injury induces nuclear factor-κB activation (1998) Journal of Neuroscience, 18 (9), pp. 3251-3260
Basso, D.M., Fisher, L.C., Anderson, A.J., Jakeman, L.B., McTigue, D.M., Popovich, P.G., Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains (2006) Journal of Neurotrauma, 23 (5), pp. 635-659
Hobart, L.J., Seibel, I., Yeargans, G.S., Seidler, N.W., Anti-crosslinking properties of carnosine: Significance of histidine (2004) Life Sciences, 75 (11), pp. 1379-1389. , DOI 10.1016/j.lfs.2004.05.002, PII S0024320504004151
Chez, M.G., Buchanan, C.P., Aimonovitch, M.C., Becker, M., Schaefer, K., Black, C., Komen, J., Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders (2002) Journal of Child Neurology, 17 (11), pp. 833-837
Stvolinsky, S.L., Kukley, M.L., Dobrota, D., Matejovicova, M., Tkac, I., Boldyrev, A.A., Carnosine: An endogenous neuroprotector in the ischemic brain (1999) Cellular and Molecular Neurobiology, 19 (1), pp. 45-56. , DOI 10.1023/A:1006960407008
Kang, J.H., Kim, K.S., Enhanced oligomerization of the α-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system (2003) Molecules and Cells, 15 (1), pp. 87-93
Thiel, R., Fowkes, S.W., Can cognitive deterioration associated with Down syndrome be reduced? (2005) Medical Hypotheses, 64 (3), pp. 524-532. , DOI 10.1016/j.mehy.2004.08.020, PII S0306987704004979
Petroff, O.A.C., Hyder, F., Rothman, D.L., Mattson, R.H., Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures (2001) Neurology, 56 (6), pp. 709-715
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Administration of carnosine in the treatment of acute spinal cord injury
L-Carnosine is an endogenously synthesized dipeptide composed of beta-alanine and L-histidine. It acts as a free radical scavenger and possesses antioxidant properties. L-Carnosine reduces proinflammatory and profibrotic cytokines such as transforming growth factor-beta (TGF-beta), interleukin (IL)-1, and tumor necrosis factor (TNF)-alpha in different experimental settings. In the present study, we investigated the efficacy of L and D-carnosine on the animal model of spinal cord injury (SCI). The spinal cord was exposed via a four-level T5-T8 laminectomy and SCI was produced by extradural compression of the spinal cord at level T6-T7 using an aneurysm clip with a closing force of 24 g. Treatment with D-carnosine (150 mg/kg administered i.p., 1 h and 6h, after SCI), but not L-carnosine significantly decreased (a) the degree of spinal cord inflammation and tissue injury (histological score), (b) neutrophil infiltration (myeloperoxidase activity), (c) nitrotyrosine formation, inducible NO synthase (iNOS) and Hsp70 expression, (d) proinflammatory cytokines, and (e) apoptosis (TUNEL staining, Fas ligand, Bax, and Bcl-2 expression). Furthermore, D-carnosine (150 mg/kg administered i.p., 1 h and 6 h, after SCI) significantly ameliorated the loss of limb function (evaluated by motor recovery score). Taken together, our results demonstrate the strong difference between L-carnosine and D-carnosine. The result strongly suggests that D-carnosine treatment reduces the development of inflammation and tissue injury associated with spinal cord trauma. Copyright 2011 Elsevier Inc. All rights reserved.
L-Carnosine is an endogenously synthesized dipeptide composed of beta-alanine and L-histidine. It acts as a free radical scavenger and possesses antioxidant properties. L-Carnosine reduces proinflammatory and profibrotic cytokines such as transforming growth factor-beta (TGF-beta), interleukin (IL)-1, and tumor necrosis factor (TNF)-alpha in different experimental settings. In the present study, we investigated the efficacy of L and D-carnosine on the animal model of spinal cord injury (SCI). The spinal cord was exposed via a four-level T5-T8 laminectomy and SCI was produced by extradural compression of the spinal cord at level T6-T7 using an aneurysm clip with a closing force of 24 g. Treatment with D-carnosine (150 mg/kg administered i.p., 1 h and 6h, after SCI), but not L-carnosine significantly decreased (a) the degree of spinal cord inflammation and tissue injury (histological score), (b) neutrophil infiltration (myeloperoxidase activity), (c) nitrotyrosine formation, inducible NO synthase (iNOS) and Hsp70 expression, (d) proinflammatory cytokines, and (e) apoptosis (TUNEL staining, Fas ligand, Bax, and Bcl-2 expression). Furthermore, D-carnosine (150 mg/kg administered i.p., 1 h and 6 h, after SCI) significantly ameliorated the loss of limb function (evaluated by motor recovery score). Taken together, our results demonstrate the strong difference between L-carnosine and D-carnosine. The result strongly suggests that D-carnosine treatment reduces the development of inflammation and tissue injury associated with spinal cord trauma. Copyright 2011 Elsevier Inc. All rights reserved.
Administration of carnosine in the treatment of acute spinal cord injury
Administration of carnosine in the treatment of acute spinal cord injury
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
* Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography (471 views)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic, 1078-0998linking), 2013 Apr; 19(4): 991-998.
Impact Factor: 5.475
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Greco A, Fiumara G, Gargiulo S, Gramanzini M, Brunetti A, Cuocolo A
* High-resolution positron emission tomography/computed tomography imaging of the mouse heart (466 views)
Exp Physiol Experimental Physiology (ISSN: 1469-445x, 0958-0670), 2013 Mar; 98(3): 645-651.
Impact Factor: 2.871
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (431 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (552 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (478 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Fusari M, Sorrentino N, Bottazzi EC, Del Vecchio W, Cozzolino I, Maurea S, Salvatore M, Imbriaco M
* Primary signet ring cell carcinoma of the appendix mimicking acute appendicitis (208 views)
Acta Radiologica Short Reports (ISSN: 2047-9816), 2012 Oct 5; 1(9): 2012-2012.
Impact Factor: 1.35
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Jacobs AH, Tavitian B, TheInmindG, Pappata S, Quarantelli M
* Noninvasive molecular imaging of neuroinflammation (335 views) (PDF 196 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x, 1559-7016electronic), 2012 Jul; 32(7): 1393-1415.
Impact Factor: 5.398
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Pier PM
* RE: Imaging Features of Hepato-Splenic Amyloidosis at PET/CT (293 views)
Korean Journal Of Radiology (ISSN: 1229-6929), 2012 May; 13(3): 368-369.
Impact Factor: 1.555
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M
* NF-κB as a potential therapeutic target in microbial diseases (484 views)
Mol Biosyst (ISSN: 1742-206x), 2012; 8(4): 1108-1120.
Impact Factor: 3.35
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Gargiulo S, Greco A, Gramanzini M, Petretta MP, Ferro A, Larobina M, Panico M, Brunetti A, Cuocolo A
* PET/CT imaging in mouse models of myocardial ischemia (666 views)
J Biomed Biotechnol (ISSN: 1110-7251, 1110-7243), 2012; 2012: 541872-541872.
Impact Factor: 2.88
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (462 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
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Rossi FF, Pedone C, Antonelli Incalzi R
Chronic obstructive pulmonary disease and cardiovascular disease: role of the systemic inflammation (445 views)
Recenti Prog Med (ISSN: 0034-1193, 0034-1193print), 2011 Mar; 102(3): 109-113.
Impact Factor: 0.318
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Severino V, Chambery A, Vitiello M, Cantisani M, Galdiero S, Galdiero M, Malorni L, Di Maro A, Parente A
* Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop (445 views)
J Proteome Res (ISSN: 1535-3893), 2010 Feb; 9(2): 1050-1062.
Impact Factor: 5.46
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (396 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1102 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (452 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Vitiello M, Galdiero S, D'Isanto M, D'Amico M, Di Filippo C, Cantisani M, Galdiero M, Pedone C
* Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin (323 views)
Microbes And Infection / Institut Pasteur (ISSN: 1286-4579), 2008 May; 10(6): 657-663.
Impact Factor: 2.801
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (562 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (348 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (284 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (369 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Lombardi A, D'Agostino B, Filippelli A, Pedone C, Matera MG, Falciani M, De Rosa M, Rossi F, Pavone V
Neuronorm is a potent and water soluble neurokinin A receptor antagonist (387 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 1998 Jul 7; 8(13): 1735-1740.
Impact Factor: 1.5
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (600 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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* Evidence of a Gastro-Duodenal Effect on Adipose Tissue and Brain Metabolism, Potentially Mediated by Gut–Liver Inflammation: A Study with Positron Emission Tomography and Oral 18FDG in Mice (8 views)
Int J Mol Sci (ISSN: 1422-0067electronic), 2022 Feb 28; 23 (5 ): N/D-N/D.
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La Manna S, Lopez-sanz L, Bernal S, Fortuna S, Mercurio FA, Leone M, Gomez-guerrero C, Marasco D
* Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics (22 views)
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Impact Factor: 5.572
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Guzzardi MA, La Rosa F, Campani D, Cacciato Insilla A, De Sena V, Panetta D, Brunetto MR, Bonino F, Collado MC, Iozzo P
* Maturation of the Visceral (Gut-Adipose-Liver) Network in Response to the Weaning Reaction versus Adult Age and Impact of Maternal High-Fat Diet (8 views)
Nutrients (ISSN: 2072-6643linking), 2021 Sep 28; 13 (10 ): N/D-N/D.
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Rebelos E, Iozzo P, Guzzardi MA, Brunetto MR, Bonino F
* Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease (36 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2021 Aug 14; 27(30): 4999-5018.
Impact Factor: 3.665
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Ngoc B, Vu Hoa T, N , Palumbo R, Rinaldo P, Fagoonee S, Phuc V
* Stem cell-derived exosomes for wound healing: current status and promising directions (61 views)
Minerva Med, 2021 Jun; 112(3): 384-400.
Impact Factor: 4.806
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Garello F, Boido M, Miglietti M, Bitonto V, Zenzola M, Filippi M, Arena F, Consolino L, Ghibaudi M, Terreno E
* Imaging of Inflammation in Spinal Cord Injury: Novel Insights on the Usage of PFC-Based Contrast Agents (18 views)
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Impact Factor: 4.757
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Coda AR, Anzilotti S, Boscia F, Greco A, Panico M, Gargiulo S, Gramanzini M, Zannetti A, Albanese S, Pignataro G, Annunziato L, Salvatore M, Brunetti A, De Berardinis P, Quarantelli M, Palma G, Pappata S
* In vivo imaging of CNS microglial activation/macrophage infiltration with combined [(18)F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis (149 views) (PDF 58 views)
Eur J Nucl Med (ISSN: 1619-7070linking, 1619-7089electronic, 1619-7070print), 2021 Jan; 48(1): 40-52.
Impact Factor: 7.18
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Rendina A, Drongitis D, Donizetti A, Fucci L, Milan G, Tripodi F, Giustezza F, Postiglione A, Pappata S, Ferrari R, Bossù P, Angiolillo A, Di Costanzo A, Caiazzo M, Vitale E
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J Neuropathol Exp Neurol (ISSN: 0022-3069linking), 2020 Jul 10; 79(8): 891-901.
Impact Factor: 3.51
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (112 views) (PDF 85 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Jan 4; 9(1): N/D-N/D.
Impact Factor: 5.688
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Actis GC, Pellicano R, Fagoonee S, Ribaldone DG
* History of Inflammatory Bowel Diseases (74 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2019 Nov 14; 8(11): N/D-N/D.
Impact Factor: 5.688
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Perani D, Iaccarino L, Lammertsma AA, Windhorst AD, Edison P, Boellaard R, Hansson O, Nordberg A, Jacobs AH, Bottlaender M, Brooks D, Carroll MA, Chalon S, Gee A, Gerhard A, Halldin C, Herholz K, Herth MM, Hinz R, Knudsen GM, Kuhnast B, López-picón F, Moresco RM, Pappata S, Rinne JO, Rodriguez-vieitez E, Santiago-ribeiro MJ, Turkheimer FE, Van Laere K, Varrone A, Vercouillie J, Winkeler A
* A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies (206 views)
Alzheimers Dement (ISSN: 1552-5260linking), 2019 Jun 20; N/D: N/D-N/D.
Impact Factor: 14.43
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Perani D, Iaccarino L, Jacobs AH, Lammertsma AA, Nordberg A, Windhorst AD, Gerhard A, Winkeler A, Jacobs AH, Gee A, Kuhnast B, Halldin C, Perani D, Brooks D, Rodriguez-vieitez E, Turkheimer FE, López-picón F, Knudsen GM, Vercouillie J, Rinne JO, Herholz K, Van Laere K, Santiago-ribeiro MJ, Herth MM, Carroll MA, Bottlaender M, Hansson O, Edison P, Hinz R, Boellaard R, Moresco RM, Pappata S
* Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies (253 views)
Alzheimers Dement (ISSN: 2352-8729print), 2019 Apr 16; 11: 327-332.
Impact Factor: 14.423
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Parisi V, Petraglia L, D'Esposito V, Cabaro S, Rengo G, Caruso A, Grimaldi MG, Baldascino F, De Bellis A, Vitale D, Formisano R, Ferro A, Paolillo S, Davin L, Lancellotti P, Formisano P, Perrone Filardi P, Ferrara N, Leosco D
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Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic, 0167-5273linking), 2019 Jan 1; 274: 326-330.
Impact Factor: 3.121
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Ugga L, Romeo V, Tedeschi E, Brunetti A, Quarantelli M
* Superparamagnetic iron oxide nanocolloids in MRI studies of neuroinflammation (363 views)
J Neurosci Methods (ISSN: 0165-0270linking, 1872-678xelectronic), 2018 Jun 18; 310: 12-23.
Impact Factor: 2.668
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Meli R, Pirozzi C, Pelagalli A
* New Perspectives on the Potential Role of Aquaporins (AQPs) in the Physiology of Inflammation (260 views)
Front Physiol (ISSN: 1664-042xprint, 1664-042xlinking), 2018 Feb 16; 9(FEB): 101-101.
Impact Factor: 4.134
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Garello F, Pagoto A, Arena F, Buffo A, Blasi F, Alberti D, Terreno E
* MRI visualization of neuroinflammation using VCAM-1 targeted paramagnetic micelles (231 views)
Nanomedicine (ISSN: 1549-9634, 1549-9642), 2017 Nov 8; N/D: N/D-N/D.
Impact Factor: 6.5
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Pontillo G, Cocozza S, Lanzillo R, Borrelli P, De Rosa A, Brescia Morra V, Tedeschi E, PalmaG
* Brain Susceptibility Changes in a Patient with Natalizumab-Related Progressive Multifocal Leukoencephalopathy: A Longitudinal Quantitative Susceptibility Mapping and Relaxometry Study (232 views)
Front Neurol (ISSN: 1664-2295, 1664-2295linking, 1664-2295print), 2017 Jun 19; 8: 294-294.
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Dennehy R, RomanoM, Ruggiero A, Mohamed YF, Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA, Berisio R, Mcclean S
* The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation (291 views)
Cell Microbiol (ISSN: 1462-5814), 2017 May; 19(5): e12691-e12691.
Impact Factor: 4.41
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Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (307 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
Impact Factor: 2.368
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Filippi M, Boido M, Terreno E
* Imaging of MSC transplantation in neuroscience (207 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Feb 14; 8(7): 10781-10782.
Impact Factor: 5.008
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Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E
* Successful in vivo MRI tracking of MSCs labeled with Gadoteridol in a Spinal Cord Injury experimental model (277 views)
Exp Neurol (ISSN: 0014-4886), 2016 Aug; 282: 66-77.
Impact Factor: 4.706
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Bozzetto L, Annuzzi G, Ragucci M, Di Donato O, Della Pepa G, Della Corte G, Griffo E, Anniballi G, Giacco A, Mancini M, Rivellese AA
* Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk (265 views)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2016 Jul; 26(7): 623-629.
Impact Factor: 3.679
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Vetrani C, Costabile G, Luongo D, Naviglio D, Rivellese AA, Riccardi G, Giacco R
* Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome (311 views)
Nutrition (ISSN: 0899-9007), 2016 Feb; 32(2): 217-221.
Impact Factor: 3.42
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Pane K, Sgambati V, Zanfardino A, Smaldone G, Cafaro V, Angrisano T, Pedone E, Di Gaetano S, Capasso D, Haney EF, Izzo V, Varcamonti M, Notomista E, Hancock RE, Di Donato A, Pizzo E
* A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells (426 views)
Febs J (ISSN: 1742-464x), 2016; N/D: N/D-N/D.
Impact Factor: 3.902
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
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N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Vicidomini C, Panico M, Greco A, Gargiulo S, Coda ARD, Zannetti A, Gramanzini M, Roviello GN, Quarantelli M, Alfano B, Tavitian B, Dolle F, Salvatore M, Brunetti A, Pappata S
* In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET (732 views) (PDF 263 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 2015 Mar; 42(3): 309-316.
Impact Factor: 2.429
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Klauzinska M, Bertolette D, Tippireddy S, Strizzi L, Gray PC, Gonzales M, Duroux M, Ruvo M, Wechselberger C, Castro NP, Rangel MC, Focà A, Sandomenico A, Hendrix MJC, Salomon D, Cuttitta F
* Cripto-1: an extracellular protein – connecting the sequestered biological dots (296 views)
Connect Tissue Res (ISSN: 0300-8207), 2015; N/D: N/D-N/D.
Impact Factor: 1.411
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Quarantelli M
* MRI/MRS in neuroinflammation: methodology and applications (296 views)
Clin Transl Imaging (ISSN: 2281-5872print, 2281-5872linking), 2015; 3: 475-489.
Impact Factor: 0
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Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (363 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (433 views)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
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Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (554 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
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Vitale M, Luongo D, Naviglio D, Bozzetto L, Mirabella M, Rivieccio AM, Giacco A, Rivellese AA
* Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids (388 views)
Acta Diabetol (ISSN: 0940-5429, 1432-5233electronic), 2013 Aug; 50(4): 651-654.
Impact Factor: 3.679
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (584 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (350 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
* Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography (471 views)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic, 1078-0998linking), 2013 Apr; 19(4): 991-998.
Impact Factor: 5.475
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Greco A, Fiumara G, Gargiulo S, Gramanzini M, Brunetti A, Cuocolo A
* High-resolution positron emission tomography/computed tomography imaging of the mouse heart (466 views)
Exp Physiol Experimental Physiology (ISSN: 1469-445x, 0958-0670), 2013 Mar; 98(3): 645-651.
Impact Factor: 2.871
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (431 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (552 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (478 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Fusari M, Sorrentino N, Bottazzi EC, Del Vecchio W, Cozzolino I, Maurea S, Salvatore M, Imbriaco M
* Primary signet ring cell carcinoma of the appendix mimicking acute appendicitis (208 views)
Acta Radiologica Short Reports (ISSN: 2047-9816), 2012 Oct 5; 1(9): 2012-2012.
Impact Factor: 1.35
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Jacobs AH, Tavitian B, TheInmindG, Pappata S, Quarantelli M
* Noninvasive molecular imaging of neuroinflammation (335 views) (PDF 196 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x, 1559-7016electronic), 2012 Jul; 32(7): 1393-1415.
Impact Factor: 5.398
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Pier PM
* RE: Imaging Features of Hepato-Splenic Amyloidosis at PET/CT (293 views)
Korean Journal Of Radiology (ISSN: 1229-6929), 2012 May; 13(3): 368-369.
Impact Factor: 1.555
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Vitiello M, Galdiero M, Finamore E, Galdiero S, Galdiero M
* NF-κB as a potential therapeutic target in microbial diseases (484 views)
Mol Biosyst (ISSN: 1742-206x), 2012; 8(4): 1108-1120.
Impact Factor: 3.35
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Gargiulo S, Greco A, Gramanzini M, Petretta MP, Ferro A, Larobina M, Panico M, Brunetti A, Cuocolo A
* PET/CT imaging in mouse models of myocardial ischemia (666 views)
J Biomed Biotechnol (ISSN: 1110-7251, 1110-7243), 2012; 2012: 541872-541872.
Impact Factor: 2.88
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (462 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
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Rossi FF, Pedone C, Antonelli Incalzi R
Chronic obstructive pulmonary disease and cardiovascular disease: role of the systemic inflammation (445 views)
Recenti Prog Med (ISSN: 0034-1193, 0034-1193print), 2011 Mar; 102(3): 109-113.
Impact Factor: 0.318
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Severino V, Chambery A, Vitiello M, Cantisani M, Galdiero S, Galdiero M, Malorni L, Di Maro A, Parente A
* Proteomic Analysis of Human U937 Cell Line Activation Mediated by Haemophilus influenzae Type b P2 Porin and Its Surface-Exposed Loop (445 views)
J Proteome Res (ISSN: 1535-3893), 2010 Feb; 9(2): 1050-1062.
Impact Factor: 5.46
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (396 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (358 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1102 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Chiechio S, Zammataro M, Morales ME, Busceti CL, Drago F, Th Gereau RW, Copani A, Nicoletti F
* Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain (452 views)
Mol Pharmacol (ISSN: 0026-895x), 2009; 75(5): 1014-1020.
Impact Factor: 4.531
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Vitiello M, Galdiero S, D'Isanto M, D'Amico M, Di Filippo C, Cantisani M, Galdiero M, Pedone C
* Pathophysiological changes of gram-negative bacterial infection can be reproduced by a synthetic peptide mimicking loop L7 sequence of Haemophilus influenzae porin (323 views)
Microbes And Infection / Institut Pasteur (ISSN: 1286-4579), 2008 May; 10(6): 657-663.
Impact Factor: 2.801
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (562 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, Fumero S
* Bent oligonucleotide duplexes as HMGB1 inhibitors: A comparative study (348 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1447-1450.
Impact Factor: 0.723
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Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, Moccia M
* ODN-based drugs for targeting of extracellular proteins (284 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(8-9): 1047-1050.
Impact Factor: 0.723
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Galdiero S, Vitiello M, Amodeo P, D'Isanto M, Cantisani M, Pedone C, Galdiero M
* Structural requirements for proinflammatory activity of porin P2 loop 7 from Haemophilus influenzae (514 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Apr 11; 45(14): 4491-4501.
Impact Factor: 3.633
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (369 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Lombardi A, D'Agostino B, Filippelli A, Pedone C, Matera MG, Falciani M, De Rosa M, Rossi F, Pavone V
Neuronorm is a potent and water soluble neurokinin A receptor antagonist (387 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 1998 Jul 7; 8(13): 1735-1740.
Impact Factor: 1.5
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (600 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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66 Records (62 excluding Abstracts).
Total impact factor: 316.939 (306.617 excluding Abstracts).
Total 5 year impact factor: 257.384 (247.034 excluding Abstracts).
Total impact factor: 316.939 (306.617 excluding Abstracts).
Total 5 year impact factor: 257.384 (247.034 excluding Abstracts).
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