Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy(451 views) Petretta M, Vicario ML, Spinelli L, Ferro A, Cuocolo A, Condorelli M, Bonaduce D
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2002 Dec; 4(6): 727-735.
Department of Internal Medicine, Federico II University of Naples, 80131 Naples, Italy
Department of Nuclear Medicine, Federico II University of Naples, 80131 Naples, Italy
References: Not available.
Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy
The myocardial length-tension and the force-frequency relations are important mechanisms that regulate the contractile strength of the heart. Aims: To evaluate in humans the effect on left ventricular function of the interaction between the myocardial length-tension and force-frequency relations. Methods and results: Eight patients with dilated cardiomyopathy (DCM) and 6 control subjects underwent radionuclide monitoring of left ventricular function during atrial pacing, saline loading and atrial pacing at the end of saline loading. In controls, atrial pacing reduced left ventricular end-diastolic (P
Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy
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