Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (428 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Export to BibTeX Export to EndNote
Paper type: Abstract, Conference, Research Support, Non-U. S. Gov'T,
Impact factor: 2.882, 5-year impact factor: 2.882
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84891410684&partnerID=40&md5=1b9c5cfbbff716c90bdcebba557645cc
Keywords: Cardiac Remodeling, Free Radicals, Mitochondria, Uncoupling Protein, Aconitate Hydratase, Oxidoreductase, Oxygen, Reactive Oxygen Metabolite, Ion Channel, Mitochondrial Protein, Mitochondrial Uncoupling Protein 3, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Apoptosis, Article, Cell Function, Cell Hypoxia, Cell Isolation, Cell Survival, Controlled Study, Coronary Artery Ligation, Disorders Of Mitochondrial Functions, Electron Microscopy, Embryo, Fibroblast, Gene Deletion, Heart Failure, Heart Infarction, Heart Infarction Size, Heart Mitochondrion, Heart Muscle Cell, Heart Muscle Ischemia, In Vitro Study, In Vivo Study, Knockout Mouse, Mitochondrial Membrane Potential, Mitochondrial Respiration, Nick End Labeling, Nonhuman, Positron Emission Tomography, Priority Journal, Real Time Polymerase Chain Reaction, Reperfusion Injury, Transthoracic Echocardiography, Ucp3 Gene, Wild Type, Cell Culture, Female, Genetics, Myocardial Ischemia, Reactive Oxygen Species,
Affiliations:
*** IBB - CNR ***
Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Departments of Advanced Biomedical Sciences, Federico II University, Naples, Italy
Departments of Biology, Federico II University, Naples, Italy
Department of Biology Sciences, Geology and Environment, Sannio University, Benevento, Italy
Department of Cardiology, Magna Graecia University, Catanzaro, Italy
References:
Mosterd, A., Hoes, A.W., Clinical epidemiology of heart failure (2007) Heart., 93, pp. 1137-114
Pepine, C.J., Systemic hypertension and coronary artery disease (1998) Am J Cardiol., 82, pp. 21H-24H
Tsutsui, H., Kinugawa, S., Matsushima, S., Mitochondrial oxidative stress and dysfunction in myocardial remodelling (2009) Cardiovasc Res., 81, pp. 449-456
Giordano, F.J., Oxygen, oxidative stress, hypoxia, and heart failure (2005) J Clin Invest., 115, pp. 500-508
Bhakuni, P., Chandra, M., Misra, M.K., Effect of ascorbic acid supplementation on certain oxidative stress parameters in the post reperfusion patients of myocardial infarction (2006) Mol Cell Biochem., 290, pp. 153-158
Jaxa-Chamiec, T., Bednarz, B., Herbaczynska-Cedro, K., Maciejewski, P., Ceremuzynski, L., Effects of vitamins C and E on the outcome after acute myocardial infarction in diabetics: a retrospective, hypothesis-generating analysis from the MIVIT study (2009) Cardiology., 112, pp. 219-223
Salonen, R.M., Nyyssonen, K., Kaikkonen, J., Porkkala-Sarataho, E., Voutilainen, S., Rissanen, T.H., Tuomainen, T.P., Poulsen, H.E., Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the antioxidant supplementation in Atherosclerosis Prevention (ASAP) Study (2003) Circulation., 107, pp. 947-953
Lancet (2002), 360, pp. 23-33. , MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trialYusuf, S., Dagenais, G., Pogue, J., Bosch, J., Sleight, P., Vitamin E supplementation and cardiovascular events in high-risk patients (2000) The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med., 342, pp. 154-160
Heusch, P., Canton, M., Aker, S., van de Sand, A., Konietzka, I., Rassaf, T., Menazza, S., Schulz, R., The contribution of reactive oxygen species and p38 mitogen-activated protein kinase to myofilament oxidation and progression of heart failure in rabbits (2010) Br J Pharmacol., 160, pp. 1408- 1416
Heusch, G., Schulz, R., A radical view on the contractile machinery in human heart failure (2011) J Am Coll Cardiol., 57, pp. 310-312
Canton, M., Skyschally, A., Menabo, R., Boengler, K., Gres, P., Schulz, R., Haude, M., Heusch, G., Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolization (2006) Eur Heart J., 27, pp. 875-881
Laposky, A.D., Shelton, J., Bass, J., Dugovic, C., Perrino, N., Turek, F.W., Altered sleep regulation in leptin-deficient mice (2006) Am J Physiol Regul Integr Comp Physiol., 290, pp. R894-R903
Brand, M.D., Affourtit, C., Esteves, T.C., Green, K., Lambert, A.J., Miwa, S., Pakay, J.L., Parker, N., Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins (2004) Free Radic Biol Med., 37, pp. 755-767
Casteilla, L., Rigoulet, M., Penicaud, L., Mitochondrial ROS metabolism: modulation by uncoupling proteins (2001) IUBMB Life., 52, pp. 181-188
Bezaire, V., Seifert, E.L., Harper, M.E., Uncoupling protein-3: clues in an ongoing mitochondrial mystery (2007) FASEB J., 21, pp. 312-324
Parker, N., Crichton, P.G., Vidal-Puig, A.J., Brand, M.D., Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria (2009) J Bioenerg Biomembr., 41, pp. 335-342
Azzu, V., Brand, M.D., The on-off switches of the mitochondrial uncoupling proteins (2010) Trends Biochem Sci., 35, pp. 298-307
Nabben, M., Hoeks, J., Briede, J.J., Glatz, J.F., Moonen-Kornips, E., Hesselink, M.K., Schrauwen, P., The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice (2008) FEBS Lett., 582, pp. 4147-4152
Brand, M.D., Buckingham, J.A., Esteves, T.C., Green, K., Lambert, A.J., Miwa, S., Murphy, M.P., Echtay, K.S., Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production (2004) Biochem Soc Symp., pp. 203-213
Teshima, Y., Akao, M., Jones, S.P., Marban, E., Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes (2003) Circ Res., 93, pp. 192-200
McFalls, E.O., Sluiter, W., Schoonderwoerd, K., Manintveld, O.C., Lamers, J.M., Bezstarosti, K., van Beusekom, H.M., Duncker, D.J., Mitochondrial adaptations within chronically ischemic swine myocardium (2006) J Mol Cell Cardiol., 41, pp. 980-988
Razeghi, P., Young, M.E., Ying, J., Depre, C., Uray, I.P., Kolesar, J., Shipley, G.L., Taegtmeyer, H., Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading (2002) Cardiology., 97, pp. 203-209
Vidal-Puig, A.J., Grujic, D., Zhang, C.Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Lowell, B.B., Energy metabolism in uncoupling protein 3 gene knockout mice (2000) J Biol Chem., 275, pp. 16258- 16266
Curcio, A., Noma, T., Naga Prasad, S.V., Wolf, M.J., Lemaire, A., Perrino, C., Mao, L., Rockman, H.A., Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling (2006) Am J Physiol Heart Circ Physiol., 291, pp. H1754-H1760
Cittadini, A., Monti, M.G., Petrillo, V., Esposito, G., Imparato, G., Luciani, A., Urciuolo, F., Netti, P.A., Complementary therapeutic effects of dual delivery of insulin-like growth factor-1 and vascular endothelial growth factor by gelatin microspheres in experimental heart failure (2011) Eur J Heart Fail., 13, pp. 1264-1274
Boengler, K., Hilfiker-Kleiner, D., Heusch, G., Schulz, R., Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion (2010) Basic Res Cardiol., 105, pp. 771-785
Tachibana, H., Perrino, C., Takaoka, H., Davis, R.J., Naga Prasad, S.V., Rockman, H.A., JNK1 is required to preserve cardiac function in the early response to pressure overload (2006) Biochem Biophys Res Commun., 343, pp. 1060-1066
Iaconetti, C., Polimeni, A., Sorrentino, S., Sabatino, J., Pironti, G., Esposito, G., Curcio, A., Indolfi, C., Inhibition of miR-92a increases endothelial proliferation and migration in vitro as well as reduces neointimal proliferation in vivo after vascular injury (2012) Basic Res Cardiol., 107, p. 296
Gallo, P., Latronico, M.V., Grimaldi, S., Borgia, F., Todaro, M., Jones, P., Gallinari, P., Condorelli, G., Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure (2008) Cardiovasc Res., 80, pp. 416-424
Perrino, C., Feliciello, A., Schiattarella, G.G., Esposito, G., Guerriero, R., Zaccaro, L., Del Gatto, A., Chiariello, M., AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (2010) Cardiovasc Res., 88, pp. 101-110
Esposito, G., Perrino, C., Cannavo, A., Schiattarella, G.G., Borgia, F., Sannino, A., Pironti, G., Chiariello, M., EGFR trans-activation by urotensin II receptor is mediated by beta-arrestin recruitment and confers cardioprotection in pressure overloadinduced cardiac hypertrophy (2011) Basic Res Cardiol., 106, pp. 577-589
Greco, A., Petretta, M.P., Larobina, M., Gargiulo, S., Panico, M., Nekolla, S.G., Esposito, G., Cuocolo, A., Reproducibility and accuracy of noninvasive measurement of infarct size in mice with high-resolution PET/CT (2012) J Nucl Cardiol., 19, pp. 492-499
Zhou, Y.Y., Wang, S.Q., Zhu, W.Z., Chruscinski, A., Kobilka, B.K., Ziman, B., Wang, S., Xiao, R.P., Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology (2000) Am J Physiol Heart Circ Physiol., 279, pp. H429-H436
Nadtochiy, S.M., Tompkins, A.J., Brookes, P.S., Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection (2006) Biochem J., 395, pp. 611- 618
Miller, T.D., Christian, T.F., Hopfenspirger, M.R., Hodge, D.O., Gersh, B.J., Gibbons, R.J., Infarct size after acute myocardial infarction measured by quantitative tomographic 99mTc sestamibi imaging predicts subsequent mortality (1995) Circulation., 92, pp. 334-341
Hausenloy, D.J., Baxter, G., Bell, R., Botker, H.E., Davidson, S.M., Downey, J., Heusch, G., Yellon, D.M., Translating novel strategies for cardioprotection: the hatter workshop recommendations (2010) Basic Res Cardiol., 105, pp. 677-686
Schwartz Longacre, L., Kloner, R.A., Arai, A.E., Baines, C.P., Bolli, R., Braunwald, E., Downey, J., Yellon, D.M., New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute workshop (2011) Circulation., 124, pp. 1172-1179
Mailloux, R.J., Harper, M.E., Uncoupling proteins and the control of mitochondrial reactive oxygen species production (2011) Free Radic Biol Med., 51, pp. 1106- 1115
Sack, M.N., Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance (2006) Cardiovasc Res., 72, pp. 210-219
Bodyak, N., Rigor, D.L., Chen, Y.S., Han, Y., Bisping, E., Pu, W.T., Kang, P.M., Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes (2007) Am J Physiol Heart Circ Physiol., 293, pp. H829-H835
Minners, J., van den Bos, E.J., Yellon, D.M., Schwalb, H., Opie, L.H., Sack, M.N., Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection (2000) Cardiovasc Res., 47, pp. 68-73
Rodrigo, G.C., Lawrence, C.L., Standen, N.B., Dinitrophenol pretreatment of rat ventricular myocytes protects against damage by metabolic inhibition and reperfusion (2002) J Mol Cell Cardiol., 34, pp. 555-569
Korde, A.S., Pettigrew, L.C., Craddock, S.D., Maragos, W.F., The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia (2005) J Neurochem., 94, pp. 1676-1684
Talbot, D.A., Brand, M.D., Uncoupling protein 3 protects aconitase against inactivation in isolated skeletal muscle mitochondria (2005) Biochim Biophys Acta., 1709, pp. 150-156
Trenker, M., Malli, R., Fertschai, I., Levak-Frank, S., Graier, W.F., Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport (2007) Nat Cell Biol., 9, pp. 445-452
Brookes, P.S., Parker, N., Buckingham, J.A., Vidal-Puig, A., Halestrap, A.P., Gunter, T.E., Nicholls, D.G., Brand, M.D., UCPs-unlikely calcium porters (2008) Nat Cell Biol., 10, pp. 1235-1237
De Marchi, U., Castelbou, C., Demaurex, N., Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production (2011) J Biol Chem., 286, pp. 32533- 32541
Xu, M.J., Song, P., Shirwany, N., Liang, B., Xing, J., Viollet, B., Wang, X., Zou, M.H., Impaired expression of uncoupling protein 2 causes defective postischemic angiogenesis in mice deficient in AMP-activated protein kinase alpha subunits (2011) Arterioscler Thromb Vasc Biol., 31, pp. 1757-1765
Young, M.E., Patil, S., Ying, J., Depre, C., Ahuja, H.S., Shipley, G.L., Stepkowski, S.M., Taegtmeyer, H., Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart (2001) FASEB J., 15, pp. 833-845
Thompson, K.L., Rosenzweig, B.A., Zhang, J., Knapton, A.D., Honchel, R., Lipshultz, S.E., Retief, J., Herman, E.H., Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats (2010) Cancer Chemother Pharmacol., 66, pp. 303-314
Bugger, H., Guzman, C., Zechner, C., Palmeri, M., Russell, K.S., Russell, R.R., Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation (2011) Cancer Chemother Pharmacol., 67, pp. 1381-1388
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Export to BibTeX Export to EndNote
Paper type: Abstract, Conference, Research Support, Non-U. S. Gov'T,
Impact factor: 2.882, 5-year impact factor: 2.882
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84891410684&partnerID=40&md5=1b9c5cfbbff716c90bdcebba557645cc
Keywords: Cardiac Remodeling, Free Radicals, Mitochondria, Uncoupling Protein, Aconitate Hydratase, Oxidoreductase, Oxygen, Reactive Oxygen Metabolite, Ion Channel, Mitochondrial Protein, Mitochondrial Uncoupling Protein 3, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Apoptosis, Article, Cell Function, Cell Hypoxia, Cell Isolation, Cell Survival, Controlled Study, Coronary Artery Ligation, Disorders Of Mitochondrial Functions, Electron Microscopy, Embryo, Fibroblast, Gene Deletion, Heart Failure, Heart Infarction, Heart Infarction Size, Heart Mitochondrion, Heart Muscle Cell, Heart Muscle Ischemia, In Vitro Study, In Vivo Study, Knockout Mouse, Mitochondrial Membrane Potential, Mitochondrial Respiration, Nick End Labeling, Nonhuman, Positron Emission Tomography, Priority Journal, Real Time Polymerase Chain Reaction, Reperfusion Injury, Transthoracic Echocardiography, Ucp3 Gene, Wild Type, Cell Culture, Female, Genetics, Myocardial Ischemia, Reactive Oxygen Species,
Affiliations:
*** IBB - CNR ***
Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Departments of Advanced Biomedical Sciences, Federico II University, Naples, Italy
Departments of Biology, Federico II University, Naples, Italy
Department of Biology Sciences, Geology and Environment, Sannio University, Benevento, Italy
Department of Cardiology, Magna Graecia University, Catanzaro, Italy
References:
Mosterd, A., Hoes, A.W., Clinical epidemiology of heart failure (2007) Heart., 93, pp. 1137-114
Pepine, C.J., Systemic hypertension and coronary artery disease (1998) Am J Cardiol., 82, pp. 21H-24H
Tsutsui, H., Kinugawa, S., Matsushima, S., Mitochondrial oxidative stress and dysfunction in myocardial remodelling (2009) Cardiovasc Res., 81, pp. 449-456
Giordano, F.J., Oxygen, oxidative stress, hypoxia, and heart failure (2005) J Clin Invest., 115, pp. 500-508
Bhakuni, P., Chandra, M., Misra, M.K., Effect of ascorbic acid supplementation on certain oxidative stress parameters in the post reperfusion patients of myocardial infarction (2006) Mol Cell Biochem., 290, pp. 153-158
Jaxa-Chamiec, T., Bednarz, B., Herbaczynska-Cedro, K., Maciejewski, P., Ceremuzynski, L., Effects of vitamins C and E on the outcome after acute myocardial infarction in diabetics: a retrospective, hypothesis-generating analysis from the MIVIT study (2009) Cardiology., 112, pp. 219-223
Salonen, R.M., Nyyssonen, K., Kaikkonen, J., Porkkala-Sarataho, E., Voutilainen, S., Rissanen, T.H., Tuomainen, T.P., Poulsen, H.E., Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the antioxidant supplementation in Atherosclerosis Prevention (ASAP) Study (2003) Circulation., 107, pp. 947-953
Lancet (2002), 360, pp. 23-33. , MRC/BHF heart protection study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trialYusuf, S., Dagenais, G., Pogue, J., Bosch, J., Sleight, P., Vitamin E supplementation and cardiovascular events in high-risk patients (2000) The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med., 342, pp. 154-160
Heusch, P., Canton, M., Aker, S., van de Sand, A., Konietzka, I., Rassaf, T., Menazza, S., Schulz, R., The contribution of reactive oxygen species and p38 mitogen-activated protein kinase to myofilament oxidation and progression of heart failure in rabbits (2010) Br J Pharmacol., 160, pp. 1408- 1416
Heusch, G., Schulz, R., A radical view on the contractile machinery in human heart failure (2011) J Am Coll Cardiol., 57, pp. 310-312
Canton, M., Skyschally, A., Menabo, R., Boengler, K., Gres, P., Schulz, R., Haude, M., Heusch, G., Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolization (2006) Eur Heart J., 27, pp. 875-881
Laposky, A.D., Shelton, J., Bass, J., Dugovic, C., Perrino, N., Turek, F.W., Altered sleep regulation in leptin-deficient mice (2006) Am J Physiol Regul Integr Comp Physiol., 290, pp. R894-R903
Brand, M.D., Affourtit, C., Esteves, T.C., Green, K., Lambert, A.J., Miwa, S., Pakay, J.L., Parker, N., Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins (2004) Free Radic Biol Med., 37, pp. 755-767
Casteilla, L., Rigoulet, M., Penicaud, L., Mitochondrial ROS metabolism: modulation by uncoupling proteins (2001) IUBMB Life., 52, pp. 181-188
Bezaire, V., Seifert, E.L., Harper, M.E., Uncoupling protein-3: clues in an ongoing mitochondrial mystery (2007) FASEB J., 21, pp. 312-324
Parker, N., Crichton, P.G., Vidal-Puig, A.J., Brand, M.D., Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria (2009) J Bioenerg Biomembr., 41, pp. 335-342
Azzu, V., Brand, M.D., The on-off switches of the mitochondrial uncoupling proteins (2010) Trends Biochem Sci., 35, pp. 298-307
Nabben, M., Hoeks, J., Briede, J.J., Glatz, J.F., Moonen-Kornips, E., Hesselink, M.K., Schrauwen, P., The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice (2008) FEBS Lett., 582, pp. 4147-4152
Brand, M.D., Buckingham, J.A., Esteves, T.C., Green, K., Lambert, A.J., Miwa, S., Murphy, M.P., Echtay, K.S., Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production (2004) Biochem Soc Symp., pp. 203-213
Teshima, Y., Akao, M., Jones, S.P., Marban, E., Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes (2003) Circ Res., 93, pp. 192-200
McFalls, E.O., Sluiter, W., Schoonderwoerd, K., Manintveld, O.C., Lamers, J.M., Bezstarosti, K., van Beusekom, H.M., Duncker, D.J., Mitochondrial adaptations within chronically ischemic swine myocardium (2006) J Mol Cell Cardiol., 41, pp. 980-988
Razeghi, P., Young, M.E., Ying, J., Depre, C., Uray, I.P., Kolesar, J., Shipley, G.L., Taegtmeyer, H., Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading (2002) Cardiology., 97, pp. 203-209
Vidal-Puig, A.J., Grujic, D., Zhang, C.Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Lowell, B.B., Energy metabolism in uncoupling protein 3 gene knockout mice (2000) J Biol Chem., 275, pp. 16258- 16266
Curcio, A., Noma, T., Naga Prasad, S.V., Wolf, M.J., Lemaire, A., Perrino, C., Mao, L., Rockman, H.A., Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling (2006) Am J Physiol Heart Circ Physiol., 291, pp. H1754-H1760
Cittadini, A., Monti, M.G., Petrillo, V., Esposito, G., Imparato, G., Luciani, A., Urciuolo, F., Netti, P.A., Complementary therapeutic effects of dual delivery of insulin-like growth factor-1 and vascular endothelial growth factor by gelatin microspheres in experimental heart failure (2011) Eur J Heart Fail., 13, pp. 1264-1274
Boengler, K., Hilfiker-Kleiner, D., Heusch, G., Schulz, R., Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion (2010) Basic Res Cardiol., 105, pp. 771-785
Tachibana, H., Perrino, C., Takaoka, H., Davis, R.J., Naga Prasad, S.V., Rockman, H.A., JNK1 is required to preserve cardiac function in the early response to pressure overload (2006) Biochem Biophys Res Commun., 343, pp. 1060-1066
Iaconetti, C., Polimeni, A., Sorrentino, S., Sabatino, J., Pironti, G., Esposito, G., Curcio, A., Indolfi, C., Inhibition of miR-92a increases endothelial proliferation and migration in vitro as well as reduces neointimal proliferation in vivo after vascular injury (2012) Basic Res Cardiol., 107, p. 296
Gallo, P., Latronico, M.V., Grimaldi, S., Borgia, F., Todaro, M., Jones, P., Gallinari, P., Condorelli, G., Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure (2008) Cardiovasc Res., 80, pp. 416-424
Perrino, C., Feliciello, A., Schiattarella, G.G., Esposito, G., Guerriero, R., Zaccaro, L., Del Gatto, A., Chiariello, M., AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (2010) Cardiovasc Res., 88, pp. 101-110
Esposito, G., Perrino, C., Cannavo, A., Schiattarella, G.G., Borgia, F., Sannino, A., Pironti, G., Chiariello, M., EGFR trans-activation by urotensin II receptor is mediated by beta-arrestin recruitment and confers cardioprotection in pressure overloadinduced cardiac hypertrophy (2011) Basic Res Cardiol., 106, pp. 577-589
Greco, A., Petretta, M.P., Larobina, M., Gargiulo, S., Panico, M., Nekolla, S.G., Esposito, G., Cuocolo, A., Reproducibility and accuracy of noninvasive measurement of infarct size in mice with high-resolution PET/CT (2012) J Nucl Cardiol., 19, pp. 492-499
Zhou, Y.Y., Wang, S.Q., Zhu, W.Z., Chruscinski, A., Kobilka, B.K., Ziman, B., Wang, S., Xiao, R.P., Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology (2000) Am J Physiol Heart Circ Physiol., 279, pp. H429-H436
Nadtochiy, S.M., Tompkins, A.J., Brookes, P.S., Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection (2006) Biochem J., 395, pp. 611- 618
Miller, T.D., Christian, T.F., Hopfenspirger, M.R., Hodge, D.O., Gersh, B.J., Gibbons, R.J., Infarct size after acute myocardial infarction measured by quantitative tomographic 99mTc sestamibi imaging predicts subsequent mortality (1995) Circulation., 92, pp. 334-341
Hausenloy, D.J., Baxter, G., Bell, R., Botker, H.E., Davidson, S.M., Downey, J., Heusch, G., Yellon, D.M., Translating novel strategies for cardioprotection: the hatter workshop recommendations (2010) Basic Res Cardiol., 105, pp. 677-686
Schwartz Longacre, L., Kloner, R.A., Arai, A.E., Baines, C.P., Bolli, R., Braunwald, E., Downey, J., Yellon, D.M., New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute workshop (2011) Circulation., 124, pp. 1172-1179
Mailloux, R.J., Harper, M.E., Uncoupling proteins and the control of mitochondrial reactive oxygen species production (2011) Free Radic Biol Med., 51, pp. 1106- 1115
Sack, M.N., Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance (2006) Cardiovasc Res., 72, pp. 210-219
Bodyak, N., Rigor, D.L., Chen, Y.S., Han, Y., Bisping, E., Pu, W.T., Kang, P.M., Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes (2007) Am J Physiol Heart Circ Physiol., 293, pp. H829-H835
Minners, J., van den Bos, E.J., Yellon, D.M., Schwalb, H., Opie, L.H., Sack, M.N., Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection (2000) Cardiovasc Res., 47, pp. 68-73
Rodrigo, G.C., Lawrence, C.L., Standen, N.B., Dinitrophenol pretreatment of rat ventricular myocytes protects against damage by metabolic inhibition and reperfusion (2002) J Mol Cell Cardiol., 34, pp. 555-569
Korde, A.S., Pettigrew, L.C., Craddock, S.D., Maragos, W.F., The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia (2005) J Neurochem., 94, pp. 1676-1684
Talbot, D.A., Brand, M.D., Uncoupling protein 3 protects aconitase against inactivation in isolated skeletal muscle mitochondria (2005) Biochim Biophys Acta., 1709, pp. 150-156
Trenker, M., Malli, R., Fertschai, I., Levak-Frank, S., Graier, W.F., Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport (2007) Nat Cell Biol., 9, pp. 445-452
Brookes, P.S., Parker, N., Buckingham, J.A., Vidal-Puig, A., Halestrap, A.P., Gunter, T.E., Nicholls, D.G., Brand, M.D., UCPs-unlikely calcium porters (2008) Nat Cell Biol., 10, pp. 1235-1237
De Marchi, U., Castelbou, C., Demaurex, N., Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production (2011) J Biol Chem., 286, pp. 32533- 32541
Xu, M.J., Song, P., Shirwany, N., Liang, B., Xing, J., Viollet, B., Wang, X., Zou, M.H., Impaired expression of uncoupling protein 2 causes defective postischemic angiogenesis in mice deficient in AMP-activated protein kinase alpha subunits (2011) Arterioscler Thromb Vasc Biol., 31, pp. 1757-1765
Young, M.E., Patil, S., Ying, J., Depre, C., Ahuja, H.S., Shipley, G.L., Stepkowski, S.M., Taegtmeyer, H., Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart (2001) FASEB J., 15, pp. 833-845
Thompson, K.L., Rosenzweig, B.A., Zhang, J., Knapton, A.D., Honchel, R., Lipshultz, S.E., Retief, J., Herman, E.H., Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats (2010) Cancer Chemother Pharmacol., 66, pp. 303-314
Bugger, H., Guzman, C., Zechner, C., Palmeri, M., Russell, K.S., Russell, R.R., Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation (2011) Cancer Chemother Pharmacol., 67, pp. 1381-1388
Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure
BACKGROUND: Uncoupling protein 3 (ucp3) is a member of the mitochondrial anion carrier superfamily of proteins uncoupling mitochondrial respiration. In this study, we investigated the effects of ucp3 genetic deletion on mitochondrial function and cell survival under low oxygen conditions in vitro and in vivo.; METHODS AND RESULTS: To test the effects of ucp3 deletion in vitro, murine embryonic fibroblasts and adult cardiomyocytes were isolated from wild-type (WT, n=67) and ucp3 knockout mice (ucp3(-/-), n=70). To test the effects of ucp3 genetic deletion in vivo, myocardial infarction (MI) was induced by permanent coronary artery ligation in WT and ucp3(-/-) mice. Compared with WT, ucp3(-/-) murine embryonic fibroblasts and cardiomyocytes exhibited mitochondrial dysfunction and increased mitochondrial reactive oxygen species generation and apoptotic cell death under hypoxic conditions in vitro (terminal deoxynucleotidyl transferase-dUTP nick end labeling-positive nuclei: WT hypoxia, 70.3 ± 1.2%; ucp3(-/-) hypoxia, 85.3 ± 0.9%; P
BACKGROUND: Uncoupling protein 3 (ucp3) is a member of the mitochondrial anion carrier superfamily of proteins uncoupling mitochondrial respiration. In this study, we investigated the effects of ucp3 genetic deletion on mitochondrial function and cell survival under low oxygen conditions in vitro and in vivo.; METHODS AND RESULTS: To test the effects of ucp3 deletion in vitro, murine embryonic fibroblasts and adult cardiomyocytes were isolated from wild-type (WT, n=67) and ucp3 knockout mice (ucp3(-/-), n=70). To test the effects of ucp3 genetic deletion in vivo, myocardial infarction (MI) was induced by permanent coronary artery ligation in WT and ucp3(-/-) mice. Compared with WT, ucp3(-/-) murine embryonic fibroblasts and cardiomyocytes exhibited mitochondrial dysfunction and increased mitochondrial reactive oxygen species generation and apoptotic cell death under hypoxic conditions in vitro (terminal deoxynucleotidyl transferase-dUTP nick end labeling-positive nuclei: WT hypoxia, 70.3 ± 1.2%; ucp3(-/-) hypoxia, 85.3 ± 0.9%; P
Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure
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Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure
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De Rosa V, Iommelli F, Terlizzi C, Leggiero E, Camerlingo R, Altobelli GG, Fonti R, Pastore L, Del Vecchio S
* Non-Canonical Role of PDK1 as a Negative Regulator of Apoptosis through Macromolecular Complexes Assembly at the ER-Mitochondria Interface in Oncogene-Driven NSCLC (16 views)
Cancers (ISSN: 2072-6694linking), 2021 Aug 17; 13 (16 ): N/D-N/D.
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Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O , #rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N
* Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy (164 views)
Sci Transl Med (ISSN: 1946-6234linking), 2021 Feb 17; 13(581): N/D-N/D.
Impact Factor: 17.956
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (112 views) (PDF 85 views)
J Clin Med (ISSN: 2077-0383linking, 2077-0383electronic), 2020 Jan 4; 9(1): N/D-N/D.
Impact Factor: 5.688
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Barone R, Alaimo S, Messina M, Pulvirenti A, Bastin J, Group MIMIC-A, F , Frye RE, Rizzo (mimic-ag A, Fiumara R, Meli C, Gulisano M, Maugeri F, Prato A, Russo G, Tabbì G
* A Subset of Patients With Autism Spectrum Disorders Show a Distinctive Metabolic Profile by Dried Blood Spot Analyses (181 views) (PDF 101 views)
Front Psychiatry (ISSN: 1664-0640linking), 2018 Dec 7; 9: 636-636.
Impact Factor: 2.857
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De Michele G, Sorrentino P, Nesti C, Rubegni A, Ruggiero L, Peluso S, Antenora A, Quarantelli M, Filla A, De Michele G, Santorelli FM
* Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome (269 views)
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 30; 9(AUG): 728-728.
Impact Factor: 3.508
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Banyasz A, Martinez-fernandez L, Improta R, Ketola TM, Balty C, Markovitsi D
* Radicals generated in alternating guanine-cytosine duplexes by direct absorption of low-energy UV radiation (286 views)
Phys Chem Chem Phys (ISSN: 1463-9084electronic, 1463-9076linking), 2018 Aug 22; 20(33): 21381-21389.
Impact Factor: 3.454
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Skiba J, Bernas T, Trzybinski D, Wozniak K, Ferraro G, Marasco D, Merlino A, Shafikov MZ, Czerwieniec R, Kowalski K
* Mitochondria Targeting with Luminescent Rhenium(I) Complexes (316 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2017 May 15; 22(5): N/D-N/D.
Impact Factor: 3.098
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (737 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
* Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (460 views)
Acs Med Chem Lett (ISSN: 1948-5875, 1948-5875linking), 2016 Sep 26; 7(12): 1145-1150.
Impact Factor: 3.746
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Magri A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V
* Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes (366 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2016 Mar 4; 1857(6): 789-798.
Impact Factor: 4.932
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Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (261 views)
Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315.
Impact Factor: 0
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De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (653 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (462 views)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
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Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
* New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (376 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 2015 Jan 6; 112(1): 77-85.
Impact Factor: 5.569
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (508 views)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
* Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart (433 views)
Bmc Cardiovasc Disor (ISSN: 1471-2261), 2014 Sep 8; 14(1): 98-98.
Impact Factor: 1.878
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (578 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1043 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
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Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G
* Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization (251 views)
Transl Med Unisa (ISSN: 2239-9747electronic, 2239-9747linking), 2014 Apr 8; 10: 3-7.
Impact Factor: 2.256
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (562 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Giuffrida ML, Rizzarelli E, Tomaselli GA, Satriano C, Trusso Sfrazzetto G
* A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging (373 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2014; 50(69): 9835-9838.
Impact Factor: 6.834
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (571 views)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
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Gargiulo S, Petretta MP, Gramanzini M, Greco A, Cuocolo A, Brunetti A, Salvatore M
* FDG-uptake by PET/CT in an Uncoupling Protein 3 Transgenic Murine Model of Myocardial Infarction (291 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (520 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (431 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3437 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (407 views)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (538 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Visco AM, Campo N, Vagliasindi LI, Tabbì G
* STUDY OF THE RADICAL SPECIES INDUCED BY ELECTRON-BEAM IRRADIATION IN VACUUM ON BIOMEDICAL UHMWPE (268 views)
International Journal Of Polymer Analysis And Characterization (ISSN: 1023-666x), 2010; 15(7): 424-437.
Impact Factor: 0.814
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (437 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1156 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (560 views)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (506 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
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Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (335 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (438 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (420 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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Improta R, Barone V
* Interplay of electronic, environmental, and vibrational effects in determining the hyperfine coupling constants of organic free radicals (293 views)
Chem Rev (ISSN: 0009-2665), 2004 Mar; 104(3): 1231-1253.
Impact Factor: 20.233
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (460 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (418 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (527 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Tabbì G, Cassino C, Cavigiolio G, Colangelo D, Ghiglia A, Viano I, Osella D
* Water stability and cytotoxic activity relationship of a series of ferrocenium derivatives. ESR insights on the radical production during the degradation process (638 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2002 Dec 19; 45(26): 5786-5796.
Impact Factor: 4.566
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Langella E, Improta R, Barone V
* Conformational and spectroscopic analysis of the tyrosyl radical dipeptide analogue in the gas phase and in aqueous solution by a density functional/continuum solvent model (530 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Sep 25; 124(38): 11531-11540.
Impact Factor: 6.201
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (606 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (688 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (351 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
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52 Records (47 excluding Abstracts).
Total impact factor: 236.799 (215.939 excluding Abstracts).
Total 5 year impact factor: 247.933 (225.969 excluding Abstracts).
Total impact factor: 236.799 (215.939 excluding Abstracts).
Total 5 year impact factor: 247.933 (225.969 excluding Abstracts).
428 views. Last view on Saturday 14 January 2023, 20:35:11
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