Fully automated synthesis procedure of 4-[18F]fluorobenzaldehyde by commercial synthesizer: amino-oxi peptide labelling prosthetic group (521 views)
Applied Radiation And Isotopes (ISSN: 1872-9800, 0969-8043, 0969-8043linking), 2009 Sep; 67(9): 1664-1669.
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Paper type: Journal Article,
Impact factor: 1.094, 5-year impact factor: 1.101
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67349087391&partnerID=40&md5=a9dbf09c6967fd44dbe1a7dbdbc546c2
Keywords: 18f, Automated Synthesis System, Peptides, Radiohalogenation, Activity Recovery, Automatic Synthesis, Clinical Routine, Functionalized, One-Pot Synthesis, Prosthetic Groups, Radiochemical Purity, Radiochemical Yield, Solid-Phase Extraction, Amination, Projectiles, Purification, 4 Fluorobenzaldehyde F 18, Phenyl Group, Radioisotope, Unclassified Drug, Article, Chemical Labeling, Drug Purity, Drug Synthesis, Priority Journal, Radioactivity, Reactor, Solid Phase Extraction, Fluorine Radioisotopes, Isotope Labeling, Radiopharmaceuticals, Benzaldehydes Chemistry , Peptides Chemistry , Radiopharmaceuticals Chemistry,
Affiliations:
*** IBB - CNR ***
IBB-CNR, Edificio 10, Via Pansini 5, Napoli, Italy. antonio.speranza@hotmail.com
Dipartimento di Scienze Biomorfologiche e Funzionali, Università degli Studi di Napoli Federico II, Edificio 10, Via Pansini 5, Napoli, Italy
References:
Not available.
Applied Radiation And Isotopes (ISSN: 1872-9800, 0969-8043, 0969-8043linking), 2009 Sep; 67(9): 1664-1669.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.094, 5-year impact factor: 1.101
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67349087391&partnerID=40&md5=a9dbf09c6967fd44dbe1a7dbdbc546c2
Keywords: 18f, Automated Synthesis System, Peptides, Radiohalogenation, Activity Recovery, Automatic Synthesis, Clinical Routine, Functionalized, One-Pot Synthesis, Prosthetic Groups, Radiochemical Purity, Radiochemical Yield, Solid-Phase Extraction, Amination, Projectiles, Purification, 4 Fluorobenzaldehyde F 18, Phenyl Group, Radioisotope, Unclassified Drug, Article, Chemical Labeling, Drug Purity, Drug Synthesis, Priority Journal, Radioactivity, Reactor, Solid Phase Extraction, Fluorine Radioisotopes, Isotope Labeling, Radiopharmaceuticals, Benzaldehydes Chemistry , Peptides Chemistry , Radiopharmaceuticals Chemistry,
Affiliations:
*** IBB - CNR ***
IBB-CNR, Edificio 10, Via Pansini 5, Napoli, Italy. antonio.speranza@hotmail.com
Dipartimento di Scienze Biomorfologiche e Funzionali, Università degli Studi di Napoli Federico II, Edificio 10, Via Pansini 5, Napoli, Italy
References:
Not available.
Fully automated synthesis procedure of 4-[18F]fluorobenzaldehyde by commercial synthesizer: amino-oxi peptide labelling prosthetic group
Automatic synthesis of 4-[18F]fluorobenzaldehyde has been developed by a commercially available TRACERlab™ FXF-N synthesis module to be used as prosthetic group for amino-oxy functionalized peptide labelling in clinical routine application. In addition a handmade purification device (HPD) has been setup to perform automatic cartridge purification as well as to back-up the reactor where one-pot synthesis is not applicable. Cartridges for solid phase extraction such as C18, C8, phenyl has been tested to best perform purification as well as activity recovery. Radiochemical yield (RCY) at end of synthesis (EOS) was in average 67% after about 45 min (90% decay corrected at EOB). The RCY of the entire procedure was 54% with a radiochemical purity above 99%. © 2009 Elsevier Ltd. All rights reserved.
Automatic synthesis of 4-[18F]fluorobenzaldehyde has been developed by a commercially available TRACERlab™ FXF-N synthesis module to be used as prosthetic group for amino-oxy functionalized peptide labelling in clinical routine application. In addition a handmade purification device (HPD) has been setup to perform automatic cartridge purification as well as to back-up the reactor where one-pot synthesis is not applicable. Cartridges for solid phase extraction such as C18, C8, phenyl has been tested to best perform purification as well as activity recovery. Radiochemical yield (RCY) at end of synthesis (EOS) was in average 67% after about 45 min (90% decay corrected at EOB). The RCY of the entire procedure was 54% with a radiochemical purity above 99%. © 2009 Elsevier Ltd. All rights reserved.
Fully automated synthesis procedure of 4-[18F]fluorobenzaldehyde by commercial synthesizer: amino-oxi peptide labelling prosthetic group
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