Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (385 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Export to BibTeX Export to EndNote
Paper type: Abstract, Conference,
Impact factor: 1.461, 5-year impact factor: 1.721
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862297754&partnerID=40&md5=8e1ea099099c871a8b093e0fe0037957
Keywords: Egfr Protein, Human, Epidermal Growth Factor Receptor, Monoclonal Antibody, Radiosensitizing Agent, Article, Biological Model, Computer Simulation, Drug Antagonism, Drug Effect, Gene Expression Regulation, Genetics, Metabolism, Neoplasm, Physiology, Radiation Response, Antibodies, Dose-Response Relationship, Neoplastic, Radiation-Sensitizing Agents,
Affiliations:
*** IBB - CNR ***
I.R.C.C.S., C.R.O.B Regional Cancer Hospital, Rionero in Vulture, Italy
U.O. of Radiotherapy, I.E.O. European Institute of Oncology, Milan, Italy
University of Milan, Milan, Italy
Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy
U.O. of Radiobiology, C.N.A.O, Pavia, Italy
Service of Medical Physics, I.E.O. European Institute of Oncology, Milan, Italy
Department of Radiation Oncology, IRCCS CROB, 1 Padre Pio Street, 85028, Rionero in Vulture, PZ, Italy
I. R. C. C. S., C. R. O. B Regional Cancer Hospital, Rionero in Vulture, Italy
U. O. of Radiotherapy, I. E. O. European Institute of Oncology, Milan, Italy
U. O. of Radiobiology, C. N. A. O, Pavia, Italy
References:
Lammering, G., Molecular predictor and promising target: Will EGFr now become a star in radiotherapy? (2005) Radioth Oncol, 74, pp. 89-91. , 10.1016/j.radonc.2005.01.00
Harari, P., Huang, S.M., Modulation of molecular targets to enhance radiation (2000) Clin Cancer Res, 6, pp. 323-335. , 10690506
Baumann, M., Krause, M., Dikomey, E., Dittmann, K., Dörr, W., Kasten Pisula, U., Rodemann, H.P., EGFr targeted anticancer drugs in radiotherapy: Preclinical evaluation of mechanisms (2007) Radioth Oncol, 83, pp. 238-248. , 10.1016/j.radonc.2007.04.006
Morgan, M.A., Parsels, L.A., Kollar, L.E., Normolle, D.P., Maybaum, J., Lawrence, T.S., The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancer (2008) Clin Cancer Res, 14, pp. 5142-5149. , 10.1158/1078-0432.CCR-07-4072 18698032
Fowler, J.F., The linear quadratic formula and progress in fractionated radiotherapy (1989) Brit J Rad, 62, pp. 679-694. , 10.1259/0007-1285-62-740-679
Niemierko, A., Goitein, M., Implementation of model for estimating tumour control probability for an inhomogeneously irradiated tumour (1993) Radioth Oncol, 29, pp. 140-147. , 10.1016/0167-8140(93)90239-5
Zaider, M., Hanin, L., Biologically equivalent dose and long term survival time in radiation treatments (2007) Phys Med Biol, 52, pp. 6355-6362. , 10.1088/0031-9155/52/20/017 17921589
Dubray, B.M., Thames, H.D., The clinical significance of ratios of radiobiological parameters (1996) Int J Radiat Oncol Biol Phys, 35, pp. 1099-1111. , 10.1016/0360-3016(96)00255-6 8751420
Barendsen, G.W., Dose fractionation, dose rate and isoeffect relationships for normal tissue responses (1982) Int J Radiat Oncol Biol Phys, 8, pp. 779-790
Hendry, J.H., Bentzen, S.M., Dale, R.G., Fowler, J.F., Wheldon, T.E., Jones, B., Munro, A.J., Robertson, A.G., A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy (1996) Clin Oncol, 8, pp. 297-307. , 10.1016/S0936-6555(05)80715-0
Zagars, G.K., Schultheiss, T.E., Peters, L.J., Inter tumour heterogeneity and radiation dose control curves (1987) Radioth Oncol, 8, pp. 353-362. , 10.1016/S0167-8140(87)80186-X
Eriksen, J.G., Steiniche, T., Overgaard, J., Head, D., The role of epidermal growth factor receptor and E-cadherin for the outcome of reduction in the overall treatment time of radiotherapy of supraglottic larynx squamous cell carcinoma (2005) Acta Oncol, 44, pp. 50-58. , 10.1080/02841860510007396 15848906 Cancer Study Group
Bengt, K.L., Brahme, A., The radiation response of heterogeneous tumours (2007) Phys Med, 23, pp. 91-99. , 10.1016/j.ejmp.2007.08.001 17950648
Webb, S., Nahum, A.E., A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distribution of dose and clonogenic cell density (1993) Phys Med Biol, 38, pp. 653-666. , 10.1088/0031-9155/38/6/001 8346278
Ang, K.K., Berkey, B.A., Tu, X., Zhang, H.Z., Katz, R., Hammond, E.H., Fu, K.K., Milas, L., Impact of Epidermal Growth Factor Receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma (2002) Cancer Res, 62, pp. 7350-7356. , 12499279
Dittmann, K., Mayer, C., Rodemann, H.P., Inhibition of radiation induced EGFr nuclear import by C225 (Cetuximab) suppresses DNA PK activity (2005) Radioth Oncol, 76, pp. 157-161. , 10.1016/j.radonc.2005.06.022
Akashi, Y., Okamoto, I., Iwasa, T., Yoshida, T., Hatashita, Y., Yamada, Y., Satoh, T., Nakagawa, K., Enhancement of the antitumour activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status (2008) Br J Cancer, 98, pp. 749-755. , 10.1038/sj.bjc.6604222 18253126
Bonner, J.A., Maihle, N.J., Folven, B.R., Christianson, T.J., Spain, K., The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities (1994) Int J Radiat Oncol Biol Phys, 29, pp. 243-247. , 10.1016/0360-3016(94)90269-0 8195014
Barendsen, G.W., Differences in radiosensitivity among cells in culture and in experimental tumours: Significance for the effectiveness of human cancer therapy (1987) Radioth Oncol, 8, pp. 285-300. , 10.1016/S0167-8140(87)80178-0
Fracasso, P.M., Iii, B.H., Arquette, M.A., Govindan, R., Gao, F., Wright, L.P., Goodner, S.A., Garrett, C.R., A Phase 1 Escalating Single Dose and Weekly Fixed Dose Study of Cetuximab: Pharmacokinetic and Pharmacodynamic Rationale for Dosing (2007) Clin Cancer Res, 13, pp. 986-993. , 10.1158/1078-0432.CCR-06-1542 17289894
Joiner, M.C., Van Der Kogel, A.J., The linear-quadratic approach to fractionation and calculation of isoeffect relationships (1997) Basic Clinical Radiobiology, pp. 107-122. , London: Arnold Steel GG
Barendsen, G.W., RBE as a function of dose for effects on tissues and tumours assessed by the linear quadratic model (2000) Int J Radiat Oncol Biol Phys, 46, pp. 684-685. , 10701750
Carlson, D.J., Stewart, R.D., Li, X.A., Jennings, K., Wang, J.Z., Guerrero, M., Comparison of in vitro and in vivo α/β ratios for prostate cancer (2004) Phys Med Biol, 49, pp. 4477-4491. , 10.1088/0031-9155/49/19/003 15552412
Begg, A.C., Vens, C., Genetic manipulation of radiosensitivity (2001) Int J Radiat Oncol Biol Phys, 49, pp. 367-371. , 10.1016/S0360-3016(00)01497-8 11173129
Brown, J.M., Therapeutic targets in radiotherapy (2001) Int J Radiat Oncol Biol Phys, 49, pp. 319-326. , 10.1016/S0360-3016(00)01482-6 11173124
Strigari, L., D'Andrea, M., Abate, A., Benassi, M., A heterogeneous dose distribution in simultaneous integrated boost: The role of the clonogenic cell density on the tumour control probability (2008) Phys Med Biol, 53, pp. 5257-5273. , 10.1088/0031-9155/53/19/001 18758004
Roberts, S.A., Hendry, J.H., A realistic closed-form radiobiological model of clinical tumour-control data incorporating intertumour heterogeneity (1998) Int J Radiat Oncol Biol Phys, 41, pp. 689-699. , 10.1016/S0360-3016(98)00100-X 9635721
Thariat, J., Milas, L., Ang, K.K., Integrating radiotherapy with epidermal growth factor receptor antagonists and other molecular therapeutics for the treatment of the head and neck cancer (2007) Int J Radiat Oncol Biol Phys, 69, pp. 974-984. , 10.1016/j.ijrobp.2007.06.076 17967298
Suwinski, R., Jaworska, M., Nikiel, B., Grzegorz, W., Bankowska-Wwozniak, M., Wojciech, M., Krysztof, S., Dariusz, L., Predicting the effect of accelerated fractionation in postoperative radiotherapy for head and neck cancer based on molecular marker profiles: Data from a randomized clinical trial (2010) Int J Radiat Oncol Biol Phys, 77, pp. 438-446. , 10.1016/j.ijrobp.2009.05.021 19733016
Chung, C.H., Zhang, Q., Hammond, E.M., Trotti III, A.M., Wang, H., Spencer, S., Zhang, H.Z., Ang, K.K., Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head-and-neck squamous cell carcinoma (2010) Int J Radiat Oncol Biol Phys, 81, pp. 331-338. , 20732768
Bentzen, S.M., Atasoy, B.M., Daley, F.M., Dische, S., Richman, P.I., Saunders, M.I., Trott, K.R., Wilson, G.D., Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial (2005) J Clin Oncol, 23, pp. 5560-5567. , 10.1200/JCO.2005.06.411 16110017
Smid, E.J., Stoter, T.R., Bloemena, E., Lafleur, M.V., Leemans, C.R., Van Der Waal, I., Slotman, B.J., Langendijk, J.A., The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy (2006) Int J Radiat Oncol Biol Phys, 65, pp. 1323-1329. , 10.1016/j.ijrobp.2006.03.011 16750322
Morgan, M. A., Parsels, L. A., Kollar, L. E., Normolle, D. P., Maybaum, J., Lawrence, T. S., The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancer (2008) Clin Cancer Res, 14, pp. 5142-5149. , 10. 1158/1078-0432. CCR-07-4072 18698032
Fowler, J. F., The linear quadratic formula and progress in fractionated radiotherapy (1989) Brit J Rad, 62, pp. 679-694. , 10. 1259/0007-1285-62-740-679
Dubray, B. M., Thames, H. D., The clinical significance of ratios of radiobiological parameters (1996) Int J Radiat Oncol Biol Phys, 35, pp. 1099-1111. , 10. 1016/0360-3016 (96) 00255-6 8751420
Barendsen, G. W., Dose fractionation, dose rate and isoeffect relationships for normal tissue responses (1982) Int J Radiat Oncol Biol Phys, 8, pp. 779-790
Hendry, J. H., Bentzen, S. M., Dale, R. G., Fowler, J. F., Wheldon, T. E., Jones, B., Munro, A. J., Robertson, A. G., A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy (1996) Clin Oncol, 8, pp. 297-307. , 10. 1016/S0936-6555 (05) 80715-0
Zagars, G. K., Schultheiss, T. E., Peters, L. J., Inter tumour heterogeneity and radiation dose control curves (1987) Radioth Oncol, 8, pp. 353-362. , 10. 1016/S0167-8140 (87) 80186-X
Eriksen, J. G., Steiniche, T., Overgaard, J., Head, D., The role of epidermal growth factor receptor and E-cadherin for the outcome of reduction in the overall treatment time of radiotherapy of supraglottic larynx squamous cell carcinoma (2005) Acta Oncol, 44, pp. 50-58. , 10. 1080/02841860510007396 15848906 Cancer Study Group
Bengt, K. L., Brahme, A., The radiation response of heterogeneous tumours (2007) Phys Med, 23, pp. 91-99. , 10. 1016/j. ejmp. 2007. 08. 001 17950648
Ang, K. K., Berkey, B. A., Tu, X., Zhang, H. Z., Katz, R., Hammond, E. H., Fu, K. K., Milas, L., Impact of Epidermal Growth Factor Receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma (2002) Cancer Res, 62, pp. 7350-7356. , 12499279
Bonner, J. A., Maihle, N. J., Folven, B. R., Christianson, T. J., Spain, K., The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities (1994) Int J Radiat Oncol Biol Phys, 29, pp. 243-247. , 10. 1016/0360-3016 (94) 90269-0 8195014
Fracasso, P. M., Iii, B. H., Arquette, M. A., Govindan, R., Gao, F., Wright, L. P., Goodner, S. A., Garrett, C. R., A Phase 1 Escalating Single Dose and Weekly Fixed Dose Study of Cetuximab: Pharmacokinetic and Pharmacodynamic Rationale for Dosing (2007) Clin Cancer Res, 13, pp. 986-993. , 10. 1158/1078-0432. CCR-06-1542 17289894
Joiner, M. C., Van Der Kogel, A. J., The linear-quadratic approach to fractionation and calculation of isoeffect relationships (1997) Basic Clinical Radiobiology, pp. 107-122. , London: Arnold Steel GG
Barendsen, G. W., RBE as a function of dose for effects on tissues and tumours assessed by the linear quadratic model (2000) Int J Radiat Oncol Biol Phys, 46, pp. 684-685. , 10701750
Carlson, D. J., Stewart, R. D., Li, X. A., Jennings, K., Wang, J. Z., Guerrero, M., Comparison of in vitro and in vivo / ratios for prostate cancer (2004) Phys Med Biol, 49, pp. 4477-4491. , 10. 1088/0031-9155/49/19/003 15552412
Begg, A. C., Vens, C., Genetic manipulation of radiosensitivity (2001) Int J Radiat Oncol Biol Phys, 49, pp. 367-371. , 10. 1016/S0360-3016 (00) 01497-8 11173129
Brown, J. M., Therapeutic targets in radiotherapy (2001) Int J Radiat Oncol Biol Phys, 49, pp. 319-326. , 10. 1016/S0360-3016 (00) 01482-6 11173124
Roberts, S. A., Hendry, J. H., A realistic closed-form radiobiological model of clinical tumour-control data incorporating intertumour heterogeneity (1998) Int J Radiat Oncol Biol Phys, 41, pp. 689-699. , 10. 1016/S0360-3016 (98) 00100-X 9635721
Chung, C. H., Zhang, Q., Hammond, E. M., Trotti III, A. M., Wang, H., Spencer, S., Zhang, H. Z., Ang, K. K., Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head-and-neck squamous cell carcinoma (2010) Int J Radiat Oncol Biol Phys, 81, pp. 331-338. , 20732768
Bentzen, S. M., Atasoy, B. M., Daley, F. M., Dische, S., Richman, P. I., Saunders, M. I., Trott, K. R., Wilson, G. D., Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial (2005) J Clin Oncol, 23, pp. 5560-5567. , 10. 1200/JCO. 2005. 06. 411 16110017
Smid, E. J., Stoter, T. R., Bloemena, E., Lafleur, M. V., Leemans, C. R., Van Der Waal, I., Slotman, B. J., Langendijk, J. A., The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy (2006) Int J Radiat Oncol Biol Phys, 65, pp. 1323-1329. , 10. 1016/j. ijrobp. 2006. 03. 011 16750322
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Export to BibTeX Export to EndNote
Paper type: Abstract, Conference,
Impact factor: 1.461, 5-year impact factor: 1.721
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862297754&partnerID=40&md5=8e1ea099099c871a8b093e0fe0037957
Keywords: Egfr Protein, Human, Epidermal Growth Factor Receptor, Monoclonal Antibody, Radiosensitizing Agent, Article, Biological Model, Computer Simulation, Drug Antagonism, Drug Effect, Gene Expression Regulation, Genetics, Metabolism, Neoplasm, Physiology, Radiation Response, Antibodies, Dose-Response Relationship, Neoplastic, Radiation-Sensitizing Agents,
Affiliations:
*** IBB - CNR ***
I.R.C.C.S., C.R.O.B Regional Cancer Hospital, Rionero in Vulture, Italy
U.O. of Radiotherapy, I.E.O. European Institute of Oncology, Milan, Italy
University of Milan, Milan, Italy
Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy
U.O. of Radiobiology, C.N.A.O, Pavia, Italy
Service of Medical Physics, I.E.O. European Institute of Oncology, Milan, Italy
Department of Radiation Oncology, IRCCS CROB, 1 Padre Pio Street, 85028, Rionero in Vulture, PZ, Italy
I. R. C. C. S., C. R. O. B Regional Cancer Hospital, Rionero in Vulture, Italy
U. O. of Radiotherapy, I. E. O. European Institute of Oncology, Milan, Italy
U. O. of Radiobiology, C. N. A. O, Pavia, Italy
References:
Lammering, G., Molecular predictor and promising target: Will EGFr now become a star in radiotherapy? (2005) Radioth Oncol, 74, pp. 89-91. , 10.1016/j.radonc.2005.01.00
Harari, P., Huang, S.M., Modulation of molecular targets to enhance radiation (2000) Clin Cancer Res, 6, pp. 323-335. , 10690506
Baumann, M., Krause, M., Dikomey, E., Dittmann, K., Dörr, W., Kasten Pisula, U., Rodemann, H.P., EGFr targeted anticancer drugs in radiotherapy: Preclinical evaluation of mechanisms (2007) Radioth Oncol, 83, pp. 238-248. , 10.1016/j.radonc.2007.04.006
Morgan, M.A., Parsels, L.A., Kollar, L.E., Normolle, D.P., Maybaum, J., Lawrence, T.S., The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancer (2008) Clin Cancer Res, 14, pp. 5142-5149. , 10.1158/1078-0432.CCR-07-4072 18698032
Fowler, J.F., The linear quadratic formula and progress in fractionated radiotherapy (1989) Brit J Rad, 62, pp. 679-694. , 10.1259/0007-1285-62-740-679
Niemierko, A., Goitein, M., Implementation of model for estimating tumour control probability for an inhomogeneously irradiated tumour (1993) Radioth Oncol, 29, pp. 140-147. , 10.1016/0167-8140(93)90239-5
Zaider, M., Hanin, L., Biologically equivalent dose and long term survival time in radiation treatments (2007) Phys Med Biol, 52, pp. 6355-6362. , 10.1088/0031-9155/52/20/017 17921589
Dubray, B.M., Thames, H.D., The clinical significance of ratios of radiobiological parameters (1996) Int J Radiat Oncol Biol Phys, 35, pp. 1099-1111. , 10.1016/0360-3016(96)00255-6 8751420
Barendsen, G.W., Dose fractionation, dose rate and isoeffect relationships for normal tissue responses (1982) Int J Radiat Oncol Biol Phys, 8, pp. 779-790
Hendry, J.H., Bentzen, S.M., Dale, R.G., Fowler, J.F., Wheldon, T.E., Jones, B., Munro, A.J., Robertson, A.G., A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy (1996) Clin Oncol, 8, pp. 297-307. , 10.1016/S0936-6555(05)80715-0
Zagars, G.K., Schultheiss, T.E., Peters, L.J., Inter tumour heterogeneity and radiation dose control curves (1987) Radioth Oncol, 8, pp. 353-362. , 10.1016/S0167-8140(87)80186-X
Eriksen, J.G., Steiniche, T., Overgaard, J., Head, D., The role of epidermal growth factor receptor and E-cadherin for the outcome of reduction in the overall treatment time of radiotherapy of supraglottic larynx squamous cell carcinoma (2005) Acta Oncol, 44, pp. 50-58. , 10.1080/02841860510007396 15848906 Cancer Study Group
Bengt, K.L., Brahme, A., The radiation response of heterogeneous tumours (2007) Phys Med, 23, pp. 91-99. , 10.1016/j.ejmp.2007.08.001 17950648
Webb, S., Nahum, A.E., A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distribution of dose and clonogenic cell density (1993) Phys Med Biol, 38, pp. 653-666. , 10.1088/0031-9155/38/6/001 8346278
Ang, K.K., Berkey, B.A., Tu, X., Zhang, H.Z., Katz, R., Hammond, E.H., Fu, K.K., Milas, L., Impact of Epidermal Growth Factor Receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma (2002) Cancer Res, 62, pp. 7350-7356. , 12499279
Dittmann, K., Mayer, C., Rodemann, H.P., Inhibition of radiation induced EGFr nuclear import by C225 (Cetuximab) suppresses DNA PK activity (2005) Radioth Oncol, 76, pp. 157-161. , 10.1016/j.radonc.2005.06.022
Akashi, Y., Okamoto, I., Iwasa, T., Yoshida, T., Hatashita, Y., Yamada, Y., Satoh, T., Nakagawa, K., Enhancement of the antitumour activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status (2008) Br J Cancer, 98, pp. 749-755. , 10.1038/sj.bjc.6604222 18253126
Bonner, J.A., Maihle, N.J., Folven, B.R., Christianson, T.J., Spain, K., The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities (1994) Int J Radiat Oncol Biol Phys, 29, pp. 243-247. , 10.1016/0360-3016(94)90269-0 8195014
Barendsen, G.W., Differences in radiosensitivity among cells in culture and in experimental tumours: Significance for the effectiveness of human cancer therapy (1987) Radioth Oncol, 8, pp. 285-300. , 10.1016/S0167-8140(87)80178-0
Fracasso, P.M., Iii, B.H., Arquette, M.A., Govindan, R., Gao, F., Wright, L.P., Goodner, S.A., Garrett, C.R., A Phase 1 Escalating Single Dose and Weekly Fixed Dose Study of Cetuximab: Pharmacokinetic and Pharmacodynamic Rationale for Dosing (2007) Clin Cancer Res, 13, pp. 986-993. , 10.1158/1078-0432.CCR-06-1542 17289894
Joiner, M.C., Van Der Kogel, A.J., The linear-quadratic approach to fractionation and calculation of isoeffect relationships (1997) Basic Clinical Radiobiology, pp. 107-122. , London: Arnold Steel GG
Barendsen, G.W., RBE as a function of dose for effects on tissues and tumours assessed by the linear quadratic model (2000) Int J Radiat Oncol Biol Phys, 46, pp. 684-685. , 10701750
Carlson, D.J., Stewart, R.D., Li, X.A., Jennings, K., Wang, J.Z., Guerrero, M., Comparison of in vitro and in vivo α/β ratios for prostate cancer (2004) Phys Med Biol, 49, pp. 4477-4491. , 10.1088/0031-9155/49/19/003 15552412
Begg, A.C., Vens, C., Genetic manipulation of radiosensitivity (2001) Int J Radiat Oncol Biol Phys, 49, pp. 367-371. , 10.1016/S0360-3016(00)01497-8 11173129
Brown, J.M., Therapeutic targets in radiotherapy (2001) Int J Radiat Oncol Biol Phys, 49, pp. 319-326. , 10.1016/S0360-3016(00)01482-6 11173124
Strigari, L., D'Andrea, M., Abate, A., Benassi, M., A heterogeneous dose distribution in simultaneous integrated boost: The role of the clonogenic cell density on the tumour control probability (2008) Phys Med Biol, 53, pp. 5257-5273. , 10.1088/0031-9155/53/19/001 18758004
Roberts, S.A., Hendry, J.H., A realistic closed-form radiobiological model of clinical tumour-control data incorporating intertumour heterogeneity (1998) Int J Radiat Oncol Biol Phys, 41, pp. 689-699. , 10.1016/S0360-3016(98)00100-X 9635721
Thariat, J., Milas, L., Ang, K.K., Integrating radiotherapy with epidermal growth factor receptor antagonists and other molecular therapeutics for the treatment of the head and neck cancer (2007) Int J Radiat Oncol Biol Phys, 69, pp. 974-984. , 10.1016/j.ijrobp.2007.06.076 17967298
Suwinski, R., Jaworska, M., Nikiel, B., Grzegorz, W., Bankowska-Wwozniak, M., Wojciech, M., Krysztof, S., Dariusz, L., Predicting the effect of accelerated fractionation in postoperative radiotherapy for head and neck cancer based on molecular marker profiles: Data from a randomized clinical trial (2010) Int J Radiat Oncol Biol Phys, 77, pp. 438-446. , 10.1016/j.ijrobp.2009.05.021 19733016
Chung, C.H., Zhang, Q., Hammond, E.M., Trotti III, A.M., Wang, H., Spencer, S., Zhang, H.Z., Ang, K.K., Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head-and-neck squamous cell carcinoma (2010) Int J Radiat Oncol Biol Phys, 81, pp. 331-338. , 20732768
Bentzen, S.M., Atasoy, B.M., Daley, F.M., Dische, S., Richman, P.I., Saunders, M.I., Trott, K.R., Wilson, G.D., Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial (2005) J Clin Oncol, 23, pp. 5560-5567. , 10.1200/JCO.2005.06.411 16110017
Smid, E.J., Stoter, T.R., Bloemena, E., Lafleur, M.V., Leemans, C.R., Van Der Waal, I., Slotman, B.J., Langendijk, J.A., The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy (2006) Int J Radiat Oncol Biol Phys, 65, pp. 1323-1329. , 10.1016/j.ijrobp.2006.03.011 16750322
Morgan, M. A., Parsels, L. A., Kollar, L. E., Normolle, D. P., Maybaum, J., Lawrence, T. S., The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancer (2008) Clin Cancer Res, 14, pp. 5142-5149. , 10. 1158/1078-0432. CCR-07-4072 18698032
Fowler, J. F., The linear quadratic formula and progress in fractionated radiotherapy (1989) Brit J Rad, 62, pp. 679-694. , 10. 1259/0007-1285-62-740-679
Dubray, B. M., Thames, H. D., The clinical significance of ratios of radiobiological parameters (1996) Int J Radiat Oncol Biol Phys, 35, pp. 1099-1111. , 10. 1016/0360-3016 (96) 00255-6 8751420
Barendsen, G. W., Dose fractionation, dose rate and isoeffect relationships for normal tissue responses (1982) Int J Radiat Oncol Biol Phys, 8, pp. 779-790
Hendry, J. H., Bentzen, S. M., Dale, R. G., Fowler, J. F., Wheldon, T. E., Jones, B., Munro, A. J., Robertson, A. G., A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy (1996) Clin Oncol, 8, pp. 297-307. , 10. 1016/S0936-6555 (05) 80715-0
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Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors
Purpose. To estimate the effects of heterogeneity on tumour cell sensitivity to radiotherapy combined with radiosensitizing agents attributable to differences in expression levels of Epidermal Growth Factor Receptor (EGFr). Materials and methods. Differences in radiosensitivity are not limited to cells of different cancer histotypes but also occur within the same cancer, or appear during radiotherapy if radiosensitizing drugs are combined with ionizing radiation. A modified biologically effective dose (MBED), has been introduced to account for changes in radiosensitivity parameters (α and α/β) rather than changes in dose/fraction or total dose as normally done with standard biologically effective dose (BED). The MBED approach was applied to cases of EGFr over-expression and cases where EGFr inhibitors were combined with radiation. Representative examples in clinical practice were considered. Results: Assuming membrane EGFr over-expression corresponds to reduced radiosensitivity (α H=0.15 Gy -1 and α H /β H=7.5 Gy) relative to normal radiosensitivity (α=0.2 Gy -1 and α/β=10 Gy), an increased dose per fraction of 2.42 Gy was obtained through the application of MBED, which is equivalent to the effect of a reference schedule with 30 fractions of 2 Gy. An equivalent hypo-fractionated regime with a dose per fraction of 2.80 Gy is obtained if 25 fractions are set. Dose fractionations modulated according to drug pharmacokinetics are estimated for combined treatments with biological drugs. Soft and strong modulated equivalent hypo-fractionations result from subtraction of 5 or 10 fractions, respectively. Conclusions: During this computational study, a new radiobiological tool has been introduced. The MBED allows the required dose per fraction to be estimated when tumour radiosensitivity is reduced because EGFr is over-expressed. If radiotherapy treatment is combined with EGFr inhibitors, MBED suggests new treatment strategies, with schedules modulated according to drug pharmacokinetics. © 2012 Pedicini et al.; licensee BioMed Central Ltd.
Purpose. To estimate the effects of heterogeneity on tumour cell sensitivity to radiotherapy combined with radiosensitizing agents attributable to differences in expression levels of Epidermal Growth Factor Receptor (EGFr). Materials and methods. Differences in radiosensitivity are not limited to cells of different cancer histotypes but also occur within the same cancer, or appear during radiotherapy if radiosensitizing drugs are combined with ionizing radiation. A modified biologically effective dose (MBED), has been introduced to account for changes in radiosensitivity parameters (α and α/β) rather than changes in dose/fraction or total dose as normally done with standard biologically effective dose (BED). The MBED approach was applied to cases of EGFr over-expression and cases where EGFr inhibitors were combined with radiation. Representative examples in clinical practice were considered. Results: Assuming membrane EGFr over-expression corresponds to reduced radiosensitivity (α H=0.15 Gy -1 and α H /β H=7.5 Gy) relative to normal radiosensitivity (α=0.2 Gy -1 and α/β=10 Gy), an increased dose per fraction of 2.42 Gy was obtained through the application of MBED, which is equivalent to the effect of a reference schedule with 30 fractions of 2 Gy. An equivalent hypo-fractionated regime with a dose per fraction of 2.80 Gy is obtained if 25 fractions are set. Dose fractionations modulated according to drug pharmacokinetics are estimated for combined treatments with biological drugs. Soft and strong modulated equivalent hypo-fractionations result from subtraction of 5 or 10 fractions, respectively. Conclusions: During this computational study, a new radiobiological tool has been introduced. The MBED allows the required dose per fraction to be estimated when tumour radiosensitivity is reduced because EGFr is over-expressed. If radiotherapy treatment is combined with EGFr inhibitors, MBED suggests new treatment strategies, with schedules modulated according to drug pharmacokinetics. © 2012 Pedicini et al.; licensee BioMed Central Ltd.
Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors
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Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (617 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (427 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (373 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (600 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (596 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (501 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Fonti R, Del Vecchio S, Zannetti A, De Renzo A, Catalano L, Pace L, Rotoli B, Salvatore M
* Functional Imaging Of Multidrug Resistant Phenotype By 99mtc-Mibi Scan In Patients With Multiple Myeloma (462 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004; 19(2): 165-170.
Impact Factor: 1.091
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (536 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (483 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (399 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Clemente F, De Lazzari C, Darowski M, Ferrari G, Mimmo R, Guaragno M, Tosti G
* Study of systolic pressure variation (SPV) in presence of mechanical ventilation (424 views)
Int J Artif Organs (ISSN: 0391-3988, 0391-3988print), 2002 Apr; 25(4): 313-320.
Impact Factor: 1.192
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De Lazzari C, Darowski M, Ferrari G, Clemente F, Guaragno M
* Energetic parameter changes with mechanical ventilation in conjunction with BVAD assistance (563 views)
J Med Eng Technol (ISSN: 0309-1902), 2002 Mar; 26(2): 63-70.
Impact Factor: 0.538
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (408 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (326 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (394 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
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Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (280 views)
Nucl Med Biol, 1999; 26: 681-686.
Impact Factor: 0
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (317 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (1018 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (451 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (281 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (500 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (275 views)
Chest (ISSN: 0012-3692), 1992 Nov; 102(5): 1632-1634.
Impact Factor: 2.341
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D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (623 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (463 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (411 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (294 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (292 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
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Del Vecchio S, Reynolds JC
NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (270 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
Impact Factor: 3.491
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (316 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (403 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (675 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (301 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (322 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (350 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (317 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (528 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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Purrello F, Gullo D, Brunetti A, Buscema M, Italia S, Goldfine ID, Vigneri R
Direct effects of biguanides on glucose utilization in vitro (325 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1987 Sep; 36(8): 774-776.
Impact Factor: 1.681
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Marchetti P, Benzi L, Trischitta V, Brunetti A, Cecchetti P, Ciccarone AM, Pezzino V, Vigneri R, Navalesi R
Complementary use of gel permeation and reversed-phase liquid chromatography for the analysis of A14-[125I]insulin and its degradation products in isolated human monocytes (1719 views)
J Chromatogr B Biomed Sci Appl (ISSN: 0378-4347), 1986 Apr 25; 377(C): 339-344.
Impact Factor: 1.588
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1341 views)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
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* Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry (17 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2021 Mar 20; 22(6): N/D-N/D.
Impact Factor: 4.556
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Sivaccumar J, Sandomenico A, Vitagliano L, Ruvo M
* Monoclonal Antibodies: A Prospective and Retrospective View (71 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(3): 435-471.
Impact Factor: 4.184
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Camorani S, Passariello M, Agnello L, Esposito S, Collina F, Cantile M, Di Bonito M, Ulasov IV, Fedele M, Zannetti A, De Lorenzo C, Cerchia L
* Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer (111 views) (PDF 48 views)
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Impact Factor: 7.068
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Alterio V, Kellner M, Esposito D, Liesche-starnecker F, Bua S, Supuran CT, Monti SM, Zeidler R, De Simone G
* Biochemical and structural insights into Carbonic Anhydrase XII/Fab6A10 complex (168 views)
J Mol Biol (ISSN: 0022-2836linking, 1089-8638), 2019 Dec 6; 431(24): 4910-4921.
Impact Factor: 5.067
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Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (568 views)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
* Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy (499 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017 Dec 15; 25(24): 6589-6596.
Impact Factor: 2.881
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (390 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2017 Nov 24; 24(36): 3939-3941.
Impact Factor: 3.469
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (1304 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2017 Mar 16; 18(6): 527-538.
Impact Factor: 2.774
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Strizzi L, Sandomenico A, Margaryan NV, Foca A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-ellis Z, Leonardi A, Ruvo M, Hendrix MJ
* Effects of a novel Nodal-targeting monoclonal antibody in melanoma (393 views) (PDF 211 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015 Oct 27; 6(33): 34071-34086.
Impact Factor: 5.008
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (725 views) (PDF 265 views)
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Impact Factor: 3.257
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (574 views)
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Impact Factor: 3.455
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Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (524 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
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Cella L, Palma G, Deasy JO, Oh JH, Liuzzi R, D'Avino V, Conson M, Pugliese N, Picardi M, Salvatore M, Pacelli R
* Complication probability models for radiation-induced heart valvular dysfunction: Do heart-lung interactions play a role? (504 views) (PDF 207 views)
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Impact Factor: 3.234
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Pedicini P, Fiorentino A, Simeon V, Tini P, Chiumento C, Pirtoli L, Salvatore M, Storto G
* Clinical radiobiology of glioblastoma multiforme: estimation of tumor control probability from various radiotherapy fractionation schemes (387 views)
Strahlenther Onkol (ISSN: 0179-7158, 0179-7158linking), 2014 Oct; 190(10): 925-932.
Impact Factor: 2.914
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Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (520 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (547 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Petretta M, Cuocolo A
Letter by Petretta and Cuocolo regarding article, "Four-variable risk model in men and women with heart failure" (301 views)
Circ-Heart Fail (ISSN: 1941-3289), 2014 Mar 1; 7(2): 380-380.
Impact Factor: 5.867
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Calce E, Sandomenico A, Saviano M, Ruvo M, De Luca S
* Cysteine Co-Oxidation Process Driven By Native Peptide Folding: An Example On Her2 Receptor Model System (371 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014; 46(5): 1197-1206.
Impact Factor: 3.293
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Formisano L, Nappi L, Rosa R, Marciano R, D'Amato C, D'Amato V, Damiano V, Raimondo L, Iommelli F, Scorziello A, Troncone G, Veneziani BM, Parsons SJ, De Placido S, Bianco R
* Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models (489 views)
Breast Cancer Res Biomed Central Ltd (ISSN: 1465-5411), 2014; 16(3): R45-R45.
Impact Factor: 0.635
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (2014 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (483 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (491 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
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Tagliamonte M, Marasco D, Ruggiero A, de Stradis A, Tornesello ML, Totrov M, Buonaguro FM, Buonaguro L
* HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (468 views)
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Impact Factor: 3.73
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Avitabile C, Moggio L, Malgieri G, Capasso D, Di Gaetano S, Saviano M, Pedone C, Romanelli A
* Gamma Sulphate Pna (pna S): Highly Selective Dna Binding Molecule Showing Promising Antigene Activity (451 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 7; 7(5): e35774-e35774.
Impact Factor: 3.73
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (616 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (527 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (590 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
Impact Factor: 4.07
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (530 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Troise F, Monti M, Merlino A, Cozzolino F, Fedele C, Russo Krauss I, Sica F, Pucci P, D'Alessio G, De Lorenzo C
* A novel ErbB2 epitope targeted by human antitumor immunoagents (403 views)
Febs Journal (ISSN: 1742-464x), 2011 Apr; 278(7): 1156-1166.
Impact Factor: 3.79
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (615 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (638 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (403 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (415 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1121 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (442 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Insabato L, Amelio I, Quarto M, Zannetti A, Tolino F, De Mauro G, Cerchia L, Riccio P, Baumhoer D, Condorelli G, Terracciano L, De Franciscis V
* Elevated Expression of the Tyrosine Phosphatase SHP-1 Defines a Subset of High-Grade Breast Tumors (449 views)
Oncology (ISSN: 0030-2414), 2009; 77(6): 378-384.
Impact Factor: 2.112
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Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (437 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (538 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Grimaldi P, Ruocco MR, Lanzotti MA, Ruggiero A, Ruggiero I, Arcari P, Vitagliano L, Masullo M
* Characterisation of the components of the thioredoxin system in the archaeon Sulfolobus solfataricus (370 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2008 Jul; 12(4): 553-562.
Impact Factor: 1.782
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (617 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (427 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (373 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (600 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (596 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (501 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Fonti R, Del Vecchio S, Zannetti A, De Renzo A, Catalano L, Pace L, Rotoli B, Salvatore M
* Functional Imaging Of Multidrug Resistant Phenotype By 99mtc-Mibi Scan In Patients With Multiple Myeloma (462 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004; 19(2): 165-170.
Impact Factor: 1.091
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (536 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (483 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (399 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Clemente F, De Lazzari C, Darowski M, Ferrari G, Mimmo R, Guaragno M, Tosti G
* Study of systolic pressure variation (SPV) in presence of mechanical ventilation (424 views)
Int J Artif Organs (ISSN: 0391-3988, 0391-3988print), 2002 Apr; 25(4): 313-320.
Impact Factor: 1.192
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De Lazzari C, Darowski M, Ferrari G, Clemente F, Guaragno M
* Energetic parameter changes with mechanical ventilation in conjunction with BVAD assistance (563 views)
J Med Eng Technol (ISSN: 0309-1902), 2002 Mar; 26(2): 63-70.
Impact Factor: 0.538
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (408 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (326 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (394 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
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Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (280 views)
Nucl Med Biol, 1999; 26: 681-686.
Impact Factor: 0
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (317 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (1018 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (451 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (281 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (500 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (327 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (275 views)
Chest (ISSN: 0012-3692), 1992 Nov; 102(5): 1632-1634.
Impact Factor: 2.341
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D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (623 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (463 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (411 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (294 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (292 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
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Del Vecchio S, Reynolds JC
NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (270 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
Impact Factor: 3.491
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (316 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (403 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (675 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (301 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (322 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (350 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (317 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (528 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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Purrello F, Gullo D, Brunetti A, Buscema M, Italia S, Goldfine ID, Vigneri R
Direct effects of biguanides on glucose utilization in vitro (325 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1987 Sep; 36(8): 774-776.
Impact Factor: 1.681
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Marchetti P, Benzi L, Trischitta V, Brunetti A, Cecchetti P, Ciccarone AM, Pezzino V, Vigneri R, Navalesi R
Complementary use of gel permeation and reversed-phase liquid chromatography for the analysis of A14-[125I]insulin and its degradation products in isolated human monocytes (1719 views)
J Chromatogr B Biomed Sci Appl (ISSN: 0378-4347), 1986 Apr 25; 377(C): 339-344.
Impact Factor: 1.588
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1341 views)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
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86 Records (79 excluding Abstracts).
Total impact factor: 318.894 (296.465 excluding Abstracts).
Total 5 year impact factor: 340.787 (313.88 excluding Abstracts).
Total impact factor: 318.894 (296.465 excluding Abstracts).
Total 5 year impact factor: 340.787 (313.88 excluding Abstracts).
385 views. Last view on Friday 19 May 2023, 12:22:54
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