Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes (595 views)
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
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Paper type: Journal Article,
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Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0026349889&partnerID=40&md5=eb8d6a4328e632cdf99bd6ada08d22bf
Keywords: Autoimmunity, Islet Cell Antibodies, Metabolic Control, Type 1 Diabetes, Urinary Neopterin, Pancreas Islet Cell Antibody, Adolescent, Adult, Article, Controlled Study, Diagnosis, Disease Course, Etiology, Female, Human, Immunofluorescence Test, Insulin Dependent Diabetes Mellitus, Metabolic Regulation, Priority Journal, School Child, Sex Difference, Urinalysis, Autoantibodies, Biopterin, Insulin-Dependent, Hemoglobin A, Glycosylated, Islets Of Langerhans, Probability, Reference Values, Regression Analysis, Time Factors,
Affiliations:
Universita Cattolica, Istituto di Clinica Medica, Largo A. Gemelli, 8, 00168 Roma, Italy
References:
Not available.
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0, 5-year impact factor: 0
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0026349889&partnerID=40&md5=eb8d6a4328e632cdf99bd6ada08d22bf
Keywords: Autoimmunity, Islet Cell Antibodies, Metabolic Control, Type 1 Diabetes, Urinary Neopterin, Pancreas Islet Cell Antibody, Adolescent, Adult, Article, Controlled Study, Diagnosis, Disease Course, Etiology, Female, Human, Immunofluorescence Test, Insulin Dependent Diabetes Mellitus, Metabolic Regulation, Priority Journal, School Child, Sex Difference, Urinalysis, Autoantibodies, Biopterin, Insulin-Dependent, Hemoglobin A, Glycosylated, Islets Of Langerhans, Probability, Reference Values, Regression Analysis, Time Factors,
Affiliations:
Universita Cattolica, Istituto di Clinica Medica, Largo A. Gemelli, 8, 00168 Roma, Italy
References:
Not available.
Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes
Neopterin is specifically produced by interferon-activated macrophages, and it may be considered a marker of cellular immunity. In 40 newly diagnosed and 38 longer standing type 1 (insulin-dependent) diabetics the relationship between urinary neopterin levels and islet cell antibodies (ICA) was investigated. Raised urinary neopterin levels were found in 30 ICA positive (mean ± SD: 729.8±602.1μmol/mol creatinine, p=0.0001) and 10 ICA negative (433.4±191.2μmol/mol creatinine, p=0.0005) diabetics at onset of disease compared with age-matched control subjects (118.1±33.2μmol/mol creatinine). No significant difference in urinary neopterin levels was observed between diabetic groups. After the first stages of disease (>5 months from onset), a significant difference (p=0.0002) in urinary neopterin excretion was found between longer standing ICA positive patients and controls, but not between ICA negative diabetics and controls. In longer standing diabetics, neopterin levels were significantly higher in ICA positive patients than in ICA negative patients (544.6±341.3 versus 201.7±180μmol/mol creatinine, p=0.0002). No correlation between newly diagnosed or longer standing patients and HbA(1c) levels was found. Our results suggest that increased neopterin excretion in type 1 diabetes seems to be a sensitive indicator for the activation of cell-mediated immunity even when ICA are undetectable.
Neopterin is specifically produced by interferon-activated macrophages, and it may be considered a marker of cellular immunity. In 40 newly diagnosed and 38 longer standing type 1 (insulin-dependent) diabetics the relationship between urinary neopterin levels and islet cell antibodies (ICA) was investigated. Raised urinary neopterin levels were found in 30 ICA positive (mean ± SD: 729.8±602.1μmol/mol creatinine, p=0.0001) and 10 ICA negative (433.4±191.2μmol/mol creatinine, p=0.0005) diabetics at onset of disease compared with age-matched control subjects (118.1±33.2μmol/mol creatinine). No significant difference in urinary neopterin levels was observed between diabetic groups. After the first stages of disease (>5 months from onset), a significant difference (p=0.0002) in urinary neopterin excretion was found between longer standing ICA positive patients and controls, but not between ICA negative diabetics and controls. In longer standing diabetics, neopterin levels were significantly higher in ICA positive patients than in ICA negative patients (544.6±341.3 versus 201.7±180μmol/mol creatinine, p=0.0002). No correlation between newly diagnosed or longer standing patients and HbA(1c) levels was found. Our results suggest that increased neopterin excretion in type 1 diabetes seems to be a sensitive indicator for the activation of cell-mediated immunity even when ICA are undetectable.
Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes
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Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes
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* Facioscapulohumeral muscular dystrophy (FSHD) and multiple sclerosis: a case report (100 views)
Acta Myol (ISSN: 1128-2460linking), 2020 Mar 1; 39(1): 29-31.
Impact Factor: 1.13
View Export to BibTeX Export to EndNote
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Clin Immunol (ISSN: 1521-6616, 1521-6616linking), 2017 Oct; 183: 249-253.
Impact Factor: 3.557
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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4 Records (4 excluding Abstracts).
Total impact factor: 27.724 (27.724 excluding Abstracts).
Total 5 year impact factor: 31.051 (31.051 excluding Abstracts).
Total impact factor: 27.724 (27.724 excluding Abstracts).
Total 5 year impact factor: 31.051 (31.051 excluding Abstracts).
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