Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains (326 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x), 2013 Jan 11; 430(2): 523-528.
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Paper type: Journal Article,
Impact factor: 2.281, 5-year impact factor: 2.474
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84872318990&partnerID=40&md5=0f03cd082ac8da857dbdbea5bf849d62
Keywords: Acute Myeloid Leukemia, Protein Denaturation, Protein Secondary Structure Content, Structure-Stability Relationships, Nucleophosmin, Amino Terminal Sequence, Article, Carboxy Terminal Sequence, Chemical Parameters, Chemical Stability, Priority Journal, Protein Analysis, Protein Interaction, Protein Stability, Temperature, Thermostability, Amino Acid Sequence, Heating, Humans, Molecular Chaperones, Molecular Sequence Data, Nuclear Proteins, Protein Multimerization, Protein Structure, Tertiary,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16, I-80134 Napoli, Italy
Department of Biological Sciences, University Federico II of Naples, Via Mezzocannone 16, 80134 Naples, Italy
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
References:
Apic, G., Gough, J., Teichmann, S.A., Domain combinations in archaeal, eubacterial and eukaryotic proteomes (2001) Journal of Molecular Biology, 310, pp. 311-32
Okuwaki, M., The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein (2008) Journal of Biochemistry, 143, pp. 441-448
Frehlick, L.J., Eirin-Lopez, J.M., Ausio, J., New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones, BioEssays: news and reviews in molecular (2007) Cellular and Developmental Biology, 29, pp. 49-59
Lim, M.J., Wang, X.W., Nucleophosmin and human cancer (2006) Cancer Detection and Prevention, 30, pp. 481-490
Grisendi, S., Mecucci, C., Falini, B., Pandolfi, P.P., Nucleophosmin and cancer (2006) Nature Reviews Cancer, 6, pp. 493-505
Grisendi, S., Bernardi, R., Rossi, M., Cheng, K., Khandker, L., Manova, K., Pandolfi, P.P., Role of nucleophosmin in embryonic development and tumorigenesis (2005) Nature, 437, pp. 147-153
Falini, B., Gionfriddo, I., Cecchetti, F., Ballanti, S., Pettirossi, V., Martelli, M.P., Acute myeloid leukemia with mutated nucleophosmin (NPM1): any hope for a targeted therapy? (2011) Blood Reviews, 25, pp. 247-254
Hingorani, K., Szebeni, A., Olson, M.O., Mapping the functional domains of nucleolar protein B23 (2000) The Journal of Biological Chemistry, 275, pp. 24451-24457
Lee, H.H., Kim, H.S., Kang, J.Y., Lee, B.I., Ha, J.Y., Yoon, H.J., Lim, S.O., Suh, S.W., Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface (2007) Proteins, 69, pp. 672-678
Fantini, D., Vascotto, C., Marasco, D., D'Ambrosio, C., Romanello, M., Vitagliano, L., Pedone, C., Tell, G., Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (2010) Nucleic Acids Research, 38, pp. 8239-8256
Vascotto, C., Fantini, D., Romanello, M., Cesaratto, L., Deganuto, M., Leonardi, A., Radicella, J.P., Tell, G., APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process (2009) Molecular and Cellular Biology, 29, pp. 1834-1854
Grummitt, C.G., Townsley, F.M., Johnson, C.M., Warren, A.J., Bycroft, M., Structural consequences of nucleophosmin mutations in acute myeloid leukemia (2008) The Journal of Biological Chemistry, 283, pp. 23326-23332
Federici, L., Arcovito, A., Scaglione, G.L., Scaloni, F., Lo Sterzo, C., Di Matteo, A., Falini, B., Brunori, M., Nucleophosmin C-terminal leukemia-associated domain interacts with G-rich quadruplex forming DNA (2010) The Journal of Biological Chemistry, 285, pp. 37138-37149
Gallo, A., Lo Sterzo, C., Mori, M., Di Matteo, A., Bertini, I., Banci, L., Brunori, M., Federici, L., Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter (2012) The Journal of Biological Chemistry
Scaloni, F., Federici, L., Brunori, M., Gianni, S., Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain (2010) Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 5447-5452
Scaloni, F., Gianni, S., Federici, L., Falini, B., Brunori, M., Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance (2009) FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 23, pp. 2360-2365
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) International Journal of Peptide and Protein Research, 35, pp. 161-214
Pace, C.N., Shaw, K.L., Linear extrapolation method of analyzing solvent denaturation curves (2000) Proteins, (SUPPL. 4), pp. 1-7
Okuwaki, M., Matsumoto, K., Tsujimoto, M., Nagata, K., Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone (2001) Fatigue of Engineering Materials and Structures Letters, 506, pp. 272-276
Frehlick, L. J., Eirin-Lopez, J. M., Ausio, J., New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones, BioEssays: news and reviews in molecular (2007) Cellular and Developmental Biology, 29, pp. 49-59
Lim, M. J., Wang, X. W., Nucleophosmin and human cancer (2006) Cancer Detection and Prevention, 30, pp. 481-490
Lee, H. H., Kim, H. S., Kang, J. Y., Lee, B. I., Ha, J. Y., Yoon, H. J., Lim, S. O., Suh, S. W., Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface (2007) Proteins, 69, pp. 672-678
Grummitt, C. G., Townsley, F. M., Johnson, C. M., Warren, A. J., Bycroft, M., Structural consequences of nucleophosmin mutations in acute myeloid leukemia (2008) The Journal of Biological Chemistry, 283, pp. 23326-23332
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) International Journal of Peptide and Protein Research, 35, pp. 161-214
Pace, C. N., Shaw, K. L., Linear extrapolation method of analyzing solvent denaturation curves (2000) Proteins, (SUPPL. 4), pp. 1-7
Biochemical And Biophysical Research Communications (ISSN: 0006-291x), 2013 Jan 11; 430(2): 523-528.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.281, 5-year impact factor: 2.474
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84872318990&partnerID=40&md5=0f03cd082ac8da857dbdbea5bf849d62
Keywords: Acute Myeloid Leukemia, Protein Denaturation, Protein Secondary Structure Content, Structure-Stability Relationships, Nucleophosmin, Amino Terminal Sequence, Article, Carboxy Terminal Sequence, Chemical Parameters, Chemical Stability, Priority Journal, Protein Analysis, Protein Interaction, Protein Stability, Temperature, Thermostability, Amino Acid Sequence, Heating, Humans, Molecular Chaperones, Molecular Sequence Data, Nuclear Proteins, Protein Multimerization, Protein Structure, Tertiary,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16, I-80134 Napoli, Italy
Department of Biological Sciences, University Federico II of Naples, Via Mezzocannone 16, 80134 Naples, Italy
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
References:
Apic, G., Gough, J., Teichmann, S.A., Domain combinations in archaeal, eubacterial and eukaryotic proteomes (2001) Journal of Molecular Biology, 310, pp. 311-32
Okuwaki, M., The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein (2008) Journal of Biochemistry, 143, pp. 441-448
Frehlick, L.J., Eirin-Lopez, J.M., Ausio, J., New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones, BioEssays: news and reviews in molecular (2007) Cellular and Developmental Biology, 29, pp. 49-59
Lim, M.J., Wang, X.W., Nucleophosmin and human cancer (2006) Cancer Detection and Prevention, 30, pp. 481-490
Grisendi, S., Mecucci, C., Falini, B., Pandolfi, P.P., Nucleophosmin and cancer (2006) Nature Reviews Cancer, 6, pp. 493-505
Grisendi, S., Bernardi, R., Rossi, M., Cheng, K., Khandker, L., Manova, K., Pandolfi, P.P., Role of nucleophosmin in embryonic development and tumorigenesis (2005) Nature, 437, pp. 147-153
Falini, B., Gionfriddo, I., Cecchetti, F., Ballanti, S., Pettirossi, V., Martelli, M.P., Acute myeloid leukemia with mutated nucleophosmin (NPM1): any hope for a targeted therapy? (2011) Blood Reviews, 25, pp. 247-254
Hingorani, K., Szebeni, A., Olson, M.O., Mapping the functional domains of nucleolar protein B23 (2000) The Journal of Biological Chemistry, 275, pp. 24451-24457
Lee, H.H., Kim, H.S., Kang, J.Y., Lee, B.I., Ha, J.Y., Yoon, H.J., Lim, S.O., Suh, S.W., Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface (2007) Proteins, 69, pp. 672-678
Fantini, D., Vascotto, C., Marasco, D., D'Ambrosio, C., Romanello, M., Vitagliano, L., Pedone, C., Tell, G., Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (2010) Nucleic Acids Research, 38, pp. 8239-8256
Vascotto, C., Fantini, D., Romanello, M., Cesaratto, L., Deganuto, M., Leonardi, A., Radicella, J.P., Tell, G., APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process (2009) Molecular and Cellular Biology, 29, pp. 1834-1854
Grummitt, C.G., Townsley, F.M., Johnson, C.M., Warren, A.J., Bycroft, M., Structural consequences of nucleophosmin mutations in acute myeloid leukemia (2008) The Journal of Biological Chemistry, 283, pp. 23326-23332
Federici, L., Arcovito, A., Scaglione, G.L., Scaloni, F., Lo Sterzo, C., Di Matteo, A., Falini, B., Brunori, M., Nucleophosmin C-terminal leukemia-associated domain interacts with G-rich quadruplex forming DNA (2010) The Journal of Biological Chemistry, 285, pp. 37138-37149
Gallo, A., Lo Sterzo, C., Mori, M., Di Matteo, A., Bertini, I., Banci, L., Brunori, M., Federici, L., Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter (2012) The Journal of Biological Chemistry
Scaloni, F., Federici, L., Brunori, M., Gianni, S., Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain (2010) Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 5447-5452
Scaloni, F., Gianni, S., Federici, L., Falini, B., Brunori, M., Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance (2009) FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 23, pp. 2360-2365
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) International Journal of Peptide and Protein Research, 35, pp. 161-214
Pace, C.N., Shaw, K.L., Linear extrapolation method of analyzing solvent denaturation curves (2000) Proteins, (SUPPL. 4), pp. 1-7
Okuwaki, M., Matsumoto, K., Tsujimoto, M., Nagata, K., Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone (2001) Fatigue of Engineering Materials and Structures Letters, 506, pp. 272-276
Frehlick, L. J., Eirin-Lopez, J. M., Ausio, J., New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones, BioEssays: news and reviews in molecular (2007) Cellular and Developmental Biology, 29, pp. 49-59
Lim, M. J., Wang, X. W., Nucleophosmin and human cancer (2006) Cancer Detection and Prevention, 30, pp. 481-490
Lee, H. H., Kim, H. S., Kang, J. Y., Lee, B. I., Ha, J. Y., Yoon, H. J., Lim, S. O., Suh, S. W., Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface (2007) Proteins, 69, pp. 672-678
Grummitt, C. G., Townsley, F. M., Johnson, C. M., Warren, A. J., Bycroft, M., Structural consequences of nucleophosmin mutations in acute myeloid leukemia (2008) The Journal of Biological Chemistry, 283, pp. 23326-23332
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) International Journal of Peptide and Protein Research, 35, pp. 161-214
Pace, C. N., Shaw, K. L., Linear extrapolation method of analyzing solvent denaturation curves (2000) Proteins, (SUPPL. 4), pp. 1-7
Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains
Nucleophosmin (NPM1) is a key factor involved in fundamental biological processes. Mutations involving the NPM1 gene are the most frequent molecular alterations in acute myeloid leukemia. Here we report a biophysical characterization of NPM1 and of its domains in order to gain insights into the role that inter-domain interactions plays in the protein stabilization. Thermal denaturation analyses show that the N-terminal domain is endowed with an exceptional thermal stability, as it does not unfold in the investigated temperature range (20-105 degrees C). This finding is corroborated by chemical denaturation experiments showing that this domain is not significantly affected by the addition of 8 M urea. These results are consistent with the chaperone function of NPM1. In line with literature data, the other folded domain of the NPM1, a 3-helix bundle domain located at the C-terminus, shows a lower stability. Interestingly, the chemical and thermal stability of this latter domain, which embeds natural mutations related to acute myeloid leukemia, is influenced by the presence of other regions of the protein. Small but significant stabilizations of the C-terminal 3-helix bundle are provided by the adjacent unfolded fragment as well as by the rest of the protein. (C) 2012 Elsevier Inc. All rights reserved.
Nucleophosmin (NPM1) is a key factor involved in fundamental biological processes. Mutations involving the NPM1 gene are the most frequent molecular alterations in acute myeloid leukemia. Here we report a biophysical characterization of NPM1 and of its domains in order to gain insights into the role that inter-domain interactions plays in the protein stabilization. Thermal denaturation analyses show that the N-terminal domain is endowed with an exceptional thermal stability, as it does not unfold in the investigated temperature range (20-105 degrees C). This finding is corroborated by chemical denaturation experiments showing that this domain is not significantly affected by the addition of 8 M urea. These results are consistent with the chaperone function of NPM1. In line with literature data, the other folded domain of the NPM1, a 3-helix bundle domain located at the C-terminus, shows a lower stability. Interestingly, the chemical and thermal stability of this latter domain, which embeds natural mutations related to acute myeloid leukemia, is influenced by the presence of other regions of the protein. Small but significant stabilizations of the C-terminal 3-helix bundle are provided by the adjacent unfolded fragment as well as by the rest of the protein. (C) 2012 Elsevier Inc. All rights reserved.
Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains
| ▼ Generation of innovative scaffolds by manipulating hyperstable proteins |
Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains
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* Stability Against Temperature Of Sulfolobus Solfataricus Elongation Factor 1 Alpha, A Multi-Domain Protein (380 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Apr; 1784(4): 573-581.
Impact Factor: 2.233
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Manetto GD, Grasso DM, Milardi D, Pappalardo M, Guzzi R, Sportelli L, Verbeet MP, Canters GW, La Rosa C
* The role played by the α-helix in the unfolding pathway and stability of azurin: Switching between hierarchic and nonhierarchic folding (341 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 Nov 5; 8(16): 1941-1949.
Impact Factor: 3.446
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Granata V, Palladino P, Tizzano B, Negro A, Berisio R, Zagari A
* The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH (402 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Jun 15; 82(3): 234-240.
Impact Factor: 2.48
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (682 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 15; 62(3): 604-616.
Impact Factor: 3.73
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Chemical Denaturation Of The Elongation Factor 1 Alpha Isolated From The Hyperthermophilic Archaeon Sulfolobus Solfataricus (358 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Jan 24; 45(3): 719-726.
Impact Factor: 3.633
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Pedone E, Saviano M, Bartolucci S, Rossi M, Ausili A, Scire A, Bertoli E, Tanfani F
* Temperature-, SDS-, and pH-induced conformational changes in protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: A dynamic simulation and fourier transform infrared spectroscopic study (319 views)
J Proteome Res (ISSN: 1535-3893), 2005 Nov; 4(6): 1972-1980.
Impact Factor: 6.901
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Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (451 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
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Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (446 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
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Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (378 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
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Berisio R, Granata V, Vitagliano L, Zagari A
* Characterization of Collagen-Like Heterotrimers: Implications for Triple-Helix Stability (604 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 682-688.
Impact Factor: 2.863
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Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (539 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
Impact Factor: 4.101
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Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2003 Jun 1; 414(1): 121-127.
Impact Factor: 2.338
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Maglio O, Nastri F, Pavone V, Lombardi A, Degrado WF
* Preorganization of molecular binding sites in designed diiron proteins (378 views)
P Natl Acad Sci Usa (ISSN: 0027-8424print, 0027-8424linking), 2003 Apr 1; 100(7): 3772-3777.
Impact Factor: 10.272
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Guzzi R, Milardi D, La Rosa C, Grasso D, Verbeet MP, Canters GW, Sportelli L
* The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin (307 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2003 Jan 15; 31(4-5): 163-170.
Impact Factor: 1.427
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* The crystal structure of a tetrameric hemoglobin in a partial hemichrome state (553 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2002 Jul 23; 99(15): 9801-9806.
Impact Factor: 10.7
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Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (353 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (449 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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* Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions (19 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2021 Oct 2; 22 (19 ): N/D-N/D.
Impact Factor:
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Smaldone G, Coppola L, Incoronato M, Parasole R, Ripaldi M, Vitagliano L, Mirabelli P, Salvatore M
* KCTD15 Protein Expression in Peripheral Blood and Acute Myeloid Leukemia (83 views)
Diagnostics (ISSN: 2075-4418linking, 2075-4418electronic), 2020 Jun 4; 10(6): N/D-N/D.
Impact Factor: 2.36
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La Rosa C, Condorelli M, Compagnini G, Lolicato F, Milardi D, Do TN, Karttunen M, Pannuzzo M, Ramamoorthy A, Fraternali F, Collu F, Rezaei H, Strodel B, Raudino A
* Symmetry-breaking transitions in the early steps of protein self-assembly (81 views)
Eur Biophys J (ISSN: 0175-7571linking, 1432-1017), 2020 Mar; 49(2): 175-191.
Impact Factor: 2.094
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Caporale A, Monti A, Selis F, Sandomenico A, Tonon G, Ruvo M, Doti N
* A comparative analysis of catalytic activity and stability of microbial transglutaminase in controlled denaturing conditions (164 views)
J Biotechnol (ISSN: 0168-1656linking), 2019 Aug 20; 302: 48-57.
Impact Factor: 3.163
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Smaldone G, Balasco N, Pirone L, Caruso D, Di Gaetano S, Pedone EM, Vitagliano L
* Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants (153 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Jul 19; 9(1): 10519-10519.
Impact Factor: 5.078
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Della Pepa R, Cerchione C, Pugliese N, Colicchio R, Salvatore P, Sirignano C, Soscia E, Pagano L, Sanguinetti M, Pane F, Picardi M
* Diagnostic-driven antifungal approach in neutropenic patients at high risk for chronic disseminated candidiasis: preliminary observations on the role of 1, 3-ß-D-glucan antigenemia and multiphasic contrast-enhanced computed tomography (215 views) (PDF 14 views)
Supportive Care Cancer (ISSN: 0941-4355), 2018 Jun; 26(6): 1691-1694.
Impact Factor: 2.676
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (288 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
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Di Matteo A, Franceschini M, Paiardini A, Grottesi A, Chiarella S, Rocchio S, Di Natale C, Marasco D, Vitagliano L, Travaglini-allocatelli C, Federici L
* Structural investigation of Nucleophosmin interaction with the tumor suppressor Fbw7γ (240 views)
Oncogenesis (ISSN: 2157-9024), 2017; 6(9): N/D-N/D.
Impact Factor: 4.722
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Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
* Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (323 views) (PDF 192 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2016 Sep 24; 131: 106-114.
Impact Factor: 3.112
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Scognamiglio PL, Di Natale C, Leone M, Cascella R, Cecchi C, Lirussi L, Antoniali G, Riccardi D, Morelli G, Tell G, Chiti F, Marasco D
* Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia (396 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2016 Sep 13; 7(37): 59129-59143.
Impact Factor: 5.168
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Di Natale C, Scognamiglio PL, Cascella R, Cecchi C, Russo A, Leone M, Penco A, Relini A, Federici L, Di Matteo A, Chiti F, Vitagliano L, Marasco D
* Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions (333 views)
The Faseb Journal (ISSN: 1530-6860, 1530-6860electronic), 2015 Sep; 29(9): 3689-3701.
Impact Factor: 5.043
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Scognamiglio PL, Di Natale C, Leone M, Poletto M, Vitagliano L, Tell G, Marasco D
* G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection (527 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2014 Jun; 1840(6): 2050-2059.
Impact Factor: 5.353
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Graziano G, Merlino A
* Molecular bases of protein halotolerance (393 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Apr; 1844(4): 850-858.
Impact Factor: 4.882
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Merlino A, Russo Krauss I, Castellano I, Ruocco MR, Capasso A, De Vendittis E, Rossi B, Sica F
* Structural and denaturation studies of two mutants of a cold adapted superoxide dismutase point to the importance of electrostatic interactions in protein stability (642 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Mar; 1844(3): 632-640.
Impact Factor: 4.882
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Poletto M, Vascotto C, Scognamiglio PL, Lirussi L, Marasco D, Tell G
* Role Of The Unstructured N-Terminal Domain Of The Human Apurinic/Apyrimidinic Endonuclease 1 (hape1) In The Modulation Of Its Interaction With Nucleic Acids And Nucleophosmin (npm1) (496 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2013; 452(3): 545-557.
Impact Factor: 4.779
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Pirone L, Esposito C, Correale S, Graziano G, Di Gaetano S, Vitagliano L, Pedone E
* Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization (486 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: 162674-162674.
Impact Factor: 1.579
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Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (300 views)
J Struct Biol (ISSN: 1047-8477, 1047-8477linking), 2012 Feb; 177(2): 506-512.
Impact Factor: 3.361
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Ruggiero A, Dattelbaum JD, Pennacchio A, Iozzino L, Staiano M, Luchansky MS, Der BS, Berisio R, D'Auria S, Vitagliano L
* Crystallization and preliminary X-ray crystallographic analysis of ligand-free and arginine-bound forms of Thermotoga maritima arginine-binding protein (506 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Nov 1; 67(11): 1462-1465.
Impact Factor: 0.506
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Monfregola L, Bugatti V, Amodeo P, De Luca S, Vittoria V
* Physical and Water Sorption Properties of Chemically Modified Pectin with an Environmentally Friendly Process (286 views)
Biomacromolecules (ISSN: 1525-7797), 2011 Jun; 12(6): 2311-2318.
Impact Factor: 5.479
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Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
* Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions (415 views)
Nucleic Acids Res (ISSN: 1362-4962, 0305-1048, 1362-4962electronic), 2010 Dec; 38(22): 8239-8256.
Impact Factor: 7.836
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Merlino A, Russo Krauss I, Castellano I, De Vendittis E, Rossi B, Conte M, Vergara A, Sica F
* Structure and flexibility in cold-adapted iron superoxide dismutases: The case of the enzyme isolated from Pseudoalteromonas haloplanktis (543 views)
J Struct Biol (ISSN: 1047-8477, 1047-8477linking), 2010 Dec; 172(3): 343-352.
Impact Factor: 3.5
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Esposito C, Carullo C, Pedone E, Graziano G, Del Vecchio P, Berisio R
* Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: Implications for bacterial agglutination (494 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 0014-5793linking), 2010 Mar 19; 584(6): 1091-1096.
Impact Factor: 3.601
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Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA
* Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase (298 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2009 Sep; 13(5): 751-761.
Impact Factor: 2
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Attanasio F, Cataldo S, Fisichella S, Nicoletti S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease (367 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2009 Jul 14; 48(27): 6522-6531.
Impact Factor: 3.226
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Ruggiero I, Cantiello P, Lamberti A, Sorrentino A, Martucci NM, Ruggiero A, Arcone R, Vitagliano L, Arcari P, Masullo M
* Biochemical Characterisation Of The D60a Mutant Of The Elongation Factor 1 Alpha From The Archaeon Sulfolobus Solfataricus (324 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2009 Jul; 91(7): 835-842.
Impact Factor: 3.897
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (561 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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De Simone A, Esposito L, Pedone C, Vitagliano L
* Insights into stability and toxicity of amyloid-like oligomers by replica exchange molecular dynamics analyses (579 views)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 Sep 15; 95(4): 1965-1973.
Impact Factor: 4.683
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Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Stability Against Temperature Of Sulfolobus Solfataricus Elongation Factor 1 Alpha, A Multi-Domain Protein (380 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2008 Apr; 1784(4): 573-581.
Impact Factor: 2.233
View Export to BibTeX Export to EndNote
Manetto GD, Grasso DM, Milardi D, Pappalardo M, Guzzi R, Sportelli L, Verbeet MP, Canters GW, La Rosa C
* The role played by the α-helix in the unfolding pathway and stability of azurin: Switching between hierarchic and nonhierarchic folding (341 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 Nov 5; 8(16): 1941-1949.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
Granata V, Palladino P, Tizzano B, Negro A, Berisio R, Zagari A
* The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH (402 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Jun 15; 82(3): 234-240.
Impact Factor: 2.48
View Export to BibTeX Export to EndNote
Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (682 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 15; 62(3): 604-616.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
Granata V, Graziano G, Ruggiero A, Raimo G, Masullo M, Arcari P, Vitagliano L, Zagari A
* Chemical Denaturation Of The Elongation Factor 1 Alpha Isolated From The Hyperthermophilic Archaeon Sulfolobus Solfataricus (358 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Jan 24; 45(3): 719-726.
Impact Factor: 3.633
View Export to BibTeX Export to EndNote
Pedone E, Saviano M, Bartolucci S, Rossi M, Ausili A, Scire A, Bertoli E, Tanfani F
* Temperature-, SDS-, and pH-induced conformational changes in protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus: A dynamic simulation and fourier transform infrared spectroscopic study (319 views)
J Proteome Res (ISSN: 1535-3893), 2005 Nov; 4(6): 1972-1980.
Impact Factor: 6.901
View Export to BibTeX Export to EndNote
Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (451 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
View Export to BibTeX Export to EndNote
Esposito L, Daggett V
* Insight into ribonuclease A domain swapping by molecular dynamics unfolding simulations (446 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2005 Mar 8; 44(9): 3358-3368.
Impact Factor: 3.848
View Export to BibTeX Export to EndNote
Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (378 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
View Export to BibTeX Export to EndNote
Berisio R, Granata V, Vitagliano L, Zagari A
* Characterization of Collagen-Like Heterotrimers: Implications for Triple-Helix Stability (604 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004 Apr 15; 73(6): 682-688.
Impact Factor: 2.863
View Export to BibTeX Export to EndNote
Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (539 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
Impact Factor: 4.101
View Export to BibTeX Export to EndNote
Milardi D, Grasso DM, Verbeet MP, Canters GW, La Rosa C
* Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: Synergism among multiple depletions (330 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2003 Jun 1; 414(1): 121-127.
Impact Factor: 2.338
View Export to BibTeX Export to EndNote
Maglio O, Nastri F, Pavone V, Lombardi A, Degrado WF
* Preorganization of molecular binding sites in designed diiron proteins (378 views)
P Natl Acad Sci Usa (ISSN: 0027-8424print, 0027-8424linking), 2003 Apr 1; 100(7): 3772-3777.
Impact Factor: 10.272
View Export to BibTeX Export to EndNote
Guzzi R, Milardi D, La Rosa C, Grasso D, Verbeet MP, Canters GW, Sportelli L
* The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin (307 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2003 Jan 15; 31(4-5): 163-170.
Impact Factor: 1.427
View Export to BibTeX Export to EndNote
Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* The crystal structure of a tetrameric hemoglobin in a partial hemichrome state (553 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2002 Jul 23; 99(15): 9801-9806.
Impact Factor: 10.7
View Export to BibTeX Export to EndNote
Masullo M, Cantiello P, Paola B, Fiengo A, Vitagliano L, Zagari A, Arcari P
* Valine114 Replacements In The Archaeal Elongation Factor 1a Enhanced Its Ability To Interact With Aminoacyl-Trna And Kirromycin (353 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2002; 41(49): 14482-14488.
Impact Factor: 4.064
View Export to BibTeX Export to EndNote
Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (449 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
View Export to BibTeX Export to EndNote
44 Records (44 excluding Abstracts).
Total impact factor: 172.657 (172.657 excluding Abstracts).
Total 5 year impact factor: 170.933 (170.933 excluding Abstracts).
Total impact factor: 172.657 (172.657 excluding Abstracts).
Total 5 year impact factor: 170.933 (170.933 excluding Abstracts).
326 views. Last view on Sunday 19 February 2023, 17:22:00
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