A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (440 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.085, 5-year impact factor: 5.72
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84900028451&partnerID=40&md5=ae6b7249e93efd5053ddd5be2f7e7d0c
Keywords: Cxcr4, Outcome, Predictive Model, Preoperative Radio Chemotherapy, Rectal Cancer, Capecitabine, Chemokine Receptor Cxcr4, Fluorouracil, Folinic Acid, Oxaliplatin, Raltitrexed, Stromal Cell Derived Factor 1, Adjuvant Chemoradiotherapy, Adult, Advanced Cancer, Area Under The Curve, Article, Cancer Prognosis, Cancer Recurrence, Cancer Resistance, Cancer Risk, Cancer Staging, Cancer Survival, Clinical Evaluation, Clinical Feature, Controlled Study, Female, High Risk Patient, Human, Human Tissue, Immunohistochemistry, Major Clinical Study, Multiple Cycle Treatment, Outcome Assessment, Preoperative Period, Priority Journal, Protein Expression, Protein Function, Rectum Cancer, Recurrence Free Survival, Recurrence Risk, Risk Assessment, Risk Factor, Area Under Curve, Chemokine Cxcl12, Disease-Free Survival, Drug Resistance, Neoplasm, Kaplan-Meier Estimate, Middle Aged, Neoadjuvant Therapy, Neoplasm Recurrence, Local, Neoplasm Staging, Proportional Hazards Models, Radiation Tolerance, Rectal Neoplasms, Roc Curve, Tumor Markers, Biological, Chemokine Cxcl12 Metabolism, Neoplasm Physiology, Local Metabolism Mortality Pathology, Cxcr Metabolism, Cxcr4 Metabolism, Rectal Neoplasms Metabolism Mortality Pathology, Biological Analysis,
Affiliations:
*** IBB - CNR ***
Department of Oncological Immunology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Department of Gastrointestinal Medical Oncology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Department of Pathology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Department of Surgical Oncology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Department of Radiation Oncology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Institute of Biostructures and Bioimages, National Council of Research (CNR), via T. de Amicis 95, 80145 Naples, Italy
Department of Biomorphological and Functional Science, Federico II University School of Medicine, via S. Pansini 5, 80131 Naples, Italy
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University School of Medicine, via S. Pansini 5, 80131 Naples, Italy
Department of Diagnostic Imaging and Radiation Oncology, Federico II University School of Medicine, via S. Pansini 5, 80131 Naples, Italy
References:
Siegel, R., Naishadham, D., Jemal, A., Cancer statistics, 2012 (2012) CA Cancer J Clin, 62, pp. 10-2
Sauer, R., Becker, H., Hohenberger, W., Preoperative versus postoperative chemoradiotherapy for rectal cancer (2004) N Engl J Med, 351, pp. 1731-1740
Gunderson, L.L., Sargent, D.J., Tepper, J.E., Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: A pooled analysis (2004) J Clin Oncol, 22, pp. 1785-1796
Avallone, A., Delrio, P., Lastoria, S., Chemo-radiotherapy in locally advanced rectal cancer: What is the optimal strategy? (2008) Eur J Cancer Suppl, 6, pp. 70-73
Bujko, K., Glynne-Jones, R., Bujko, M., Does adjuvant fluoropyrimidine-based chemotherapy provide a benefit for patients with resected rectal cancer who have already received neoadjuvant radiochemotherapy?. A systematic review of randomised trials (2010) Ann Oncol, 21, pp. 1743-1750
Avallone, A., Aloj, L., Delrio, P., Multidisciplinary approach to rectal cancer: Are we ready for selective treatment strategies? (2013) Anticancer Agents Med Chem, 13, pp. 852-860
Rodel, C., Martus, P., Papadoupolos, T., Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer (2005) J Clin Oncol, 23, pp. 8688-8696
Bujko, K., Michalski, W., Kepka, L., Association between pathologic response in metastatic lymph nodes after preoperative chemoradiotherapy and risk of distant metastases in rectal cancer: An analysis of outcomes in a randomized trial (2007) Int J Radiat Oncol Biol Phys, 67, pp. 369-377
Fietkau, R., Barten, M., Klautke, G., Postoperative chemotherapy may not be necessary for patients with ypN0-category after neoadjuvant chemoradiotherapy of rectal cancer (2006) Dis Colon Rectum, 49, pp. 1284-1292
Maas, M., Nelemans, P.J., Valentini, V., Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: A pooled analysis of individual patient data (2010) Lancet Oncol, 11, pp. 835-844
Valentini, V., Van Stiphout, R.G., Lammering, G., Nomograms for predicting local recurrence, #distant |metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials (2011) J Clin Oncol, 29, pp. 3163-3172
Kim, J., Mori, T., Chen, S.L., Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome (2006) Ann Surg, 244, pp. 113-120
Ottaiano, A., Franco, R., Talamanca, A., Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients (2006) Clin Cancer Res, 12, pp. 2795-2803
Zhang, S.S., Han, Z.P., Jing, Y.Y., CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients (2012) BMC Med, 10, p. 85
Saigusa, S., Toiyama, Y., Tanaka, K., Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy (2010) Ann Surg Oncol, 17, pp. 2051-2058
Orimo, A., Gupta, P.B., Sgroi, D.C., Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion (2005) Cell, 121, pp. 335-348
Ingold, B., Schulz, S., Budczies, J., The role of vascular CXCR4 expression in colorectal carcinoma (2009) Histopathology, 55, pp. 576-586
Brand, S., Dambacher, J., Beigel, F., CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation (2005) Exp Cell Res, 310, pp. 117-130
Thelen, M., Thelen, S., CXCR7, CXCR4 and CXCL12: An eccentric trio? (2008) J Neuroimmunol, 198, pp. 9-13
Miao, Z., Luker, K.E., Summers, B.C., CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature (2007) Proc Natl Acad Sci USA, 104, pp. 15735-15740
D'Alterio, C., Consales, C., Polimeno, M., Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer (2010) Curr Cancer Drug Targets, 10, pp. 772-781
Xu, H., Wu, Q., Dang, S., Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma (2011) PLoS One, 6, pp. e27399
Avallone, A., Di Gennaro, E., Delrio, P., Neoadjuvant multidisciplinary phase II study (BRANCH) of an early bevacizumab schedule plus chemo-radiation therapy in rectal cancer: Efficacy, safety, and biomarkers (2012) AACR Meeting, , abstract LB219
Akishima-Fukasawa, Y., Nakanishi, Y., Ino, Y., Prognostic significance of CXCL12 expression in patients with colorectal carcinoma (2009) Am J Clin Pathol, 132, pp. 202-210
Pacelli, R., Conson, M., Cella, L., Radiation therapy following surgery for localized breast cancer:outcome prediction by classical prognostic factors and approximated genetic subtypes (2013) J Rad Res, 54, pp. 292-298
El Naqa, I., Bradley, J., Blanco, A.I., Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical factors (2006) Int J Radiat Oncol Biol Phys, 64, pp. 1275-1286
Hernandez, L., Magalhaes, M.A., Coniglio, S.J., Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis (2011) Breast Cancer Res, 13, pp. R128
Carlomagno, C., Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (2009) Ann Oncol, 20, pp. 906-912
Drury, L.J., Ziarek, J.J., Gravel, S., Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways (2011) Proc Natl Acad Sci USA, 108, pp. 17655-17660
Heinrich, E.L., Lee, W., Lu, J., Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells (2012) J Transl Med, 10, p. 68
Hiller, D.J., Li, B.D., Chu, Q.D., CXCR4 as a predictive marker for locally advanced breast cancer post-neoadjuvant therapy (2011) J Surg Res, 166, pp. 14-18
Margolin, D.A., Silinsky, J., Grimes, C., Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1α/CXCR4 paracrine signaling (2011) Neoplasia, 13, pp. 874-886
Allegra, C.J., Yothers, G., O'Connell, M.J., Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08 (2011) J Clin Oncol, 29, pp. 11-16
Dewdney, A., Cunningham, D., Tabernero, J., Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C) (2012) J Clin Oncol, 30, pp. 1620-1627
Willett, C.G., Duda, D.G., Ancukiewicz, M., A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer (2010) Oncologist, 15, pp. 845-851
Hiratsuka, S., Duda, D.G., Huang, Y., C-X-C receptor type4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells (2011) Proc Natl Acad Sci USA., 108, pp. 302-307
Xu, L., Duda, D.G., Di Tomaso, E., Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer (2009) Cancer Res, 69, pp. 7905-7910
De Clercq, E., The AMD3100 story: The path to the discovery of a stem cell mobilizer (Mozobil) (2009) Biochem Pharmacol, 77, pp. 1655-1664
Gunderson, L. L., Sargent, D. J., Tepper, J. E., Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: A pooled analysis (2004) J Clin Oncol, 22, pp. 1785-1796
Zhang, S. S., Han, Z. P., Jing, Y. Y., CD133 (+) CXCR4 (+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients (2012) BMC Med, 10, p. 85
Drury, L. J., Ziarek, J. J., Gravel, S., Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways (2011) Proc Natl Acad Sci USA, 108, pp. 17655-17660
Heinrich, E. L., Lee, W., Lu, J., Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells (2012) J Transl Med, 10, p. 68
Hiller, D. J., Li, B. D., Chu, Q. D., CXCR4 as a predictive marker for locally advanced breast cancer post-neoadjuvant therapy (2011) J Surg Res, 166, pp. 14-18
Margolin, D. A., Silinsky, J., Grimes, C., Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1 /CXCR4 paracrine signaling (2011) Neoplasia, 13, pp. 874-886
Allegra, C. J., Yothers, G., O'Connell, M. J., Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08 (2011) J Clin Oncol, 29, pp. 11-16
Willett, C. G., Duda, D. G., Ancukiewicz, M., A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer (2010) Oncologist, 15, pp. 845-851
Xu, L., Duda, D. G., Di Tomaso, E., Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer (2009) Cancer Res, 69, pp. 7905-7910
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.085, 5-year impact factor: 5.72
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84900028451&partnerID=40&md5=ae6b7249e93efd5053ddd5be2f7e7d0c
Keywords: Cxcr4, Outcome, Predictive Model, Preoperative Radio Chemotherapy, Rectal Cancer, Capecitabine, Chemokine Receptor Cxcr4, Fluorouracil, Folinic Acid, Oxaliplatin, Raltitrexed, Stromal Cell Derived Factor 1, Adjuvant Chemoradiotherapy, Adult, Advanced Cancer, Area Under The Curve, Article, Cancer Prognosis, Cancer Recurrence, Cancer Resistance, Cancer Risk, Cancer Staging, Cancer Survival, Clinical Evaluation, Clinical Feature, Controlled Study, Female, High Risk Patient, Human, Human Tissue, Immunohistochemistry, Major Clinical Study, Multiple Cycle Treatment, Outcome Assessment, Preoperative Period, Priority Journal, Protein Expression, Protein Function, Rectum Cancer, Recurrence Free Survival, Recurrence Risk, Risk Assessment, Risk Factor, Area Under Curve, Chemokine Cxcl12, Disease-Free Survival, Drug Resistance, Neoplasm, Kaplan-Meier Estimate, Middle Aged, Neoadjuvant Therapy, Neoplasm Recurrence, Local, Neoplasm Staging, Proportional Hazards Models, Radiation Tolerance, Rectal Neoplasms, Roc Curve, Tumor Markers, Biological, Chemokine Cxcl12 Metabolism, Neoplasm Physiology, Local Metabolism Mortality Pathology, Cxcr Metabolism, Cxcr4 Metabolism, Rectal Neoplasms Metabolism Mortality Pathology, Biological Analysis,
Affiliations:
*** IBB - CNR ***
Department of Oncological Immunology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Department of Gastrointestinal Medical Oncology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Department of Pathology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Department of Surgical Oncology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Department of Radiation Oncology, Istituto Nazionale per Lo Studio e la Cura Dei Tumori Fondazione Giovanni Pascale, IRCCS-ITALIA, via M. Semmola, 80131 Naples, Italy
Institute of Biostructures and Bioimages, National Council of Research (CNR), via T. de Amicis 95, 80145 Naples, Italy
Department of Biomorphological and Functional Science, Federico II University School of Medicine, via S. Pansini 5, 80131 Naples, Italy
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University School of Medicine, via S. Pansini 5, 80131 Naples, Italy
Department of Diagnostic Imaging and Radiation Oncology, Federico II University School of Medicine, via S. Pansini 5, 80131 Naples, Italy
References:
Siegel, R., Naishadham, D., Jemal, A., Cancer statistics, 2012 (2012) CA Cancer J Clin, 62, pp. 10-2
Sauer, R., Becker, H., Hohenberger, W., Preoperative versus postoperative chemoradiotherapy for rectal cancer (2004) N Engl J Med, 351, pp. 1731-1740
Gunderson, L.L., Sargent, D.J., Tepper, J.E., Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: A pooled analysis (2004) J Clin Oncol, 22, pp. 1785-1796
Avallone, A., Delrio, P., Lastoria, S., Chemo-radiotherapy in locally advanced rectal cancer: What is the optimal strategy? (2008) Eur J Cancer Suppl, 6, pp. 70-73
Bujko, K., Glynne-Jones, R., Bujko, M., Does adjuvant fluoropyrimidine-based chemotherapy provide a benefit for patients with resected rectal cancer who have already received neoadjuvant radiochemotherapy?. A systematic review of randomised trials (2010) Ann Oncol, 21, pp. 1743-1750
Avallone, A., Aloj, L., Delrio, P., Multidisciplinary approach to rectal cancer: Are we ready for selective treatment strategies? (2013) Anticancer Agents Med Chem, 13, pp. 852-860
Rodel, C., Martus, P., Papadoupolos, T., Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer (2005) J Clin Oncol, 23, pp. 8688-8696
Bujko, K., Michalski, W., Kepka, L., Association between pathologic response in metastatic lymph nodes after preoperative chemoradiotherapy and risk of distant metastases in rectal cancer: An analysis of outcomes in a randomized trial (2007) Int J Radiat Oncol Biol Phys, 67, pp. 369-377
Fietkau, R., Barten, M., Klautke, G., Postoperative chemotherapy may not be necessary for patients with ypN0-category after neoadjuvant chemoradiotherapy of rectal cancer (2006) Dis Colon Rectum, 49, pp. 1284-1292
Maas, M., Nelemans, P.J., Valentini, V., Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: A pooled analysis of individual patient data (2010) Lancet Oncol, 11, pp. 835-844
Valentini, V., Van Stiphout, R.G., Lammering, G., Nomograms for predicting local recurrence, #distant |metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials (2011) J Clin Oncol, 29, pp. 3163-3172
Kim, J., Mori, T., Chen, S.L., Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome (2006) Ann Surg, 244, pp. 113-120
Ottaiano, A., Franco, R., Talamanca, A., Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients (2006) Clin Cancer Res, 12, pp. 2795-2803
Zhang, S.S., Han, Z.P., Jing, Y.Y., CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients (2012) BMC Med, 10, p. 85
Saigusa, S., Toiyama, Y., Tanaka, K., Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy (2010) Ann Surg Oncol, 17, pp. 2051-2058
Orimo, A., Gupta, P.B., Sgroi, D.C., Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion (2005) Cell, 121, pp. 335-348
Ingold, B., Schulz, S., Budczies, J., The role of vascular CXCR4 expression in colorectal carcinoma (2009) Histopathology, 55, pp. 576-586
Brand, S., Dambacher, J., Beigel, F., CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation (2005) Exp Cell Res, 310, pp. 117-130
Thelen, M., Thelen, S., CXCR7, CXCR4 and CXCL12: An eccentric trio? (2008) J Neuroimmunol, 198, pp. 9-13
Miao, Z., Luker, K.E., Summers, B.C., CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature (2007) Proc Natl Acad Sci USA, 104, pp. 15735-15740
D'Alterio, C., Consales, C., Polimeno, M., Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer (2010) Curr Cancer Drug Targets, 10, pp. 772-781
Xu, H., Wu, Q., Dang, S., Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma (2011) PLoS One, 6, pp. e27399
Avallone, A., Di Gennaro, E., Delrio, P., Neoadjuvant multidisciplinary phase II study (BRANCH) of an early bevacizumab schedule plus chemo-radiation therapy in rectal cancer: Efficacy, safety, and biomarkers (2012) AACR Meeting, , abstract LB219
Akishima-Fukasawa, Y., Nakanishi, Y., Ino, Y., Prognostic significance of CXCL12 expression in patients with colorectal carcinoma (2009) Am J Clin Pathol, 132, pp. 202-210
Pacelli, R., Conson, M., Cella, L., Radiation therapy following surgery for localized breast cancer:outcome prediction by classical prognostic factors and approximated genetic subtypes (2013) J Rad Res, 54, pp. 292-298
El Naqa, I., Bradley, J., Blanco, A.I., Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical factors (2006) Int J Radiat Oncol Biol Phys, 64, pp. 1275-1286
Hernandez, L., Magalhaes, M.A., Coniglio, S.J., Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis (2011) Breast Cancer Res, 13, pp. R128
Carlomagno, C., Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (2009) Ann Oncol, 20, pp. 906-912
Drury, L.J., Ziarek, J.J., Gravel, S., Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways (2011) Proc Natl Acad Sci USA, 108, pp. 17655-17660
Heinrich, E.L., Lee, W., Lu, J., Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells (2012) J Transl Med, 10, p. 68
Hiller, D.J., Li, B.D., Chu, Q.D., CXCR4 as a predictive marker for locally advanced breast cancer post-neoadjuvant therapy (2011) J Surg Res, 166, pp. 14-18
Margolin, D.A., Silinsky, J., Grimes, C., Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1α/CXCR4 paracrine signaling (2011) Neoplasia, 13, pp. 874-886
Allegra, C.J., Yothers, G., O'Connell, M.J., Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08 (2011) J Clin Oncol, 29, pp. 11-16
Dewdney, A., Cunningham, D., Tabernero, J., Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine, and preoperative radiotherapy with or without cetuximab followed by total mesorectal excision in patients with high-risk rectal cancer (EXPERT-C) (2012) J Clin Oncol, 30, pp. 1620-1627
Willett, C.G., Duda, D.G., Ancukiewicz, M., A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer (2010) Oncologist, 15, pp. 845-851
Hiratsuka, S., Duda, D.G., Huang, Y., C-X-C receptor type4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells (2011) Proc Natl Acad Sci USA., 108, pp. 302-307
Xu, L., Duda, D.G., Di Tomaso, E., Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer (2009) Cancer Res, 69, pp. 7905-7910
De Clercq, E., The AMD3100 story: The path to the discovery of a stem cell mobilizer (Mozobil) (2009) Biochem Pharmacol, 77, pp. 1655-1664
Gunderson, L. L., Sargent, D. J., Tepper, J. E., Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: A pooled analysis (2004) J Clin Oncol, 22, pp. 1785-1796
Zhang, S. S., Han, Z. P., Jing, Y. Y., CD133 (+) CXCR4 (+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients (2012) BMC Med, 10, p. 85
Drury, L. J., Ziarek, J. J., Gravel, S., Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways (2011) Proc Natl Acad Sci USA, 108, pp. 17655-17660
Heinrich, E. L., Lee, W., Lu, J., Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells (2012) J Transl Med, 10, p. 68
Hiller, D. J., Li, B. D., Chu, Q. D., CXCR4 as a predictive marker for locally advanced breast cancer post-neoadjuvant therapy (2011) J Surg Res, 166, pp. 14-18
Margolin, D. A., Silinsky, J., Grimes, C., Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1 /CXCR4 paracrine signaling (2011) Neoplasia, 13, pp. 874-886
Allegra, C. J., Yothers, G., O'Connell, M. J., Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08 (2011) J Clin Oncol, 29, pp. 11-16
Willett, C. G., Duda, D. G., Ancukiewicz, M., A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer (2010) Oncologist, 15, pp. 845-851
Xu, L., Duda, D. G., Di Tomaso, E., Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer (2009) Cancer Res, 69, pp. 7905-7910
A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients
Despite the optimization of the local treatment of advanced rectal cancer (LARC), combination of preoperative chemoradiotherapy (CRT) and surgery, approximately one third of patients will develop distant metastases. Since the chemokine receptor CXCR4 has been implicated in metastasis development and prognosis in colorectal cancer, the role of the entire axis CXCR4-CXCL12-CXCR7 was evaluated to identify high relapse risk rectal cancer patients. Tumor specimens of 68 LARC patients undergoing surgery after neoadjuvant-CRT were evaluated for CXCR4, CXCR7, and CXCL12 expression through immunohistochemistry. Multivariable prognostic model was developed using classical prognostic factors along with chemokine receptor expression profiles. High CXCR4 correlated with a shorter relapse-free survival (RFS) (p = 0.0006) and cancer specific survival (CSS) (p = 0.0004). Concomitant high CXCR4-negative/low CXCR7 or high CXCR4-negative/low CXCL12 significantly impaired RFS (p = 0.0003 and p = 0.0043) and CSS (p = 0.0485 and p = 0.0026). High CXCR4/N+ identified the worst prognostic category for RFS (p < 0.0001) and CSS (p = 0.0003). The optimal multivariable predictive model for RFS was a five-variable model consisting of gender, pT stage, N status, CXCR4, and CXCR7 (AUC = 0.92, 95% CI = 0.77-0.98). The model is informative and supportive for adjuvant treatment and identifies CXCR4 as a new therapeutic target in rectal cancer.© 2013 UICC.
Despite the optimization of the local treatment of advanced rectal cancer (LARC), combination of preoperative chemoradiotherapy (CRT) and surgery, approximately one third of patients will develop distant metastases. Since the chemokine receptor CXCR4 has been implicated in metastasis development and prognosis in colorectal cancer, the role of the entire axis CXCR4-CXCL12-CXCR7 was evaluated to identify high relapse risk rectal cancer patients. Tumor specimens of 68 LARC patients undergoing surgery after neoadjuvant-CRT were evaluated for CXCR4, CXCR7, and CXCL12 expression through immunohistochemistry. Multivariable prognostic model was developed using classical prognostic factors along with chemokine receptor expression profiles. High CXCR4 correlated with a shorter relapse-free survival (RFS) (p = 0.0006) and cancer specific survival (CSS) (p = 0.0004). Concomitant high CXCR4-negative/low CXCR7 or high CXCR4-negative/low CXCL12 significantly impaired RFS (p = 0.0003 and p = 0.0043) and CSS (p = 0.0485 and p = 0.0026). High CXCR4/N+ identified the worst prognostic category for RFS (p < 0.0001) and CSS (p = 0.0003). The optimal multivariable predictive model for RFS was a five-variable model consisting of gender, pT stage, N status, CXCR4, and CXCR7 (AUC = 0.92, 95% CI = 0.77-0.98). The model is informative and supportive for adjuvant treatment and identifies CXCR4 as a new therapeutic target in rectal cancer.© 2013 UICC.
A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients
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A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients
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Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using In Vitro and In Vivo Models (3 views)
Acs Appl Mater Interfaces (ISSN: 1944-8252electronic), 2022 Mar 09; 14 (9 ): 11078-11091.
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Stanzione A, Verde F, Romeo V, Boccadifuoco F, Mainenti PP, Maurea S
* Radiomics and machine learning applications in rectal cancer: Current update and future perspectives (39 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2021 Aug 28; 27(32): 5306-5321.
Impact Factor: 3.665
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Manco M, Ala U, Cantarella D, Tolosano E, Medico E, Altruda F, Fagoonee S
* The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells (4 views)
Cancers (ISSN: 2072-6694linking), 2021 Aug 13; 13(16): N/D-N/D.
Impact Factor: 6.126
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Susana F, Fagoonee S, Alessandro S, Valentina G, Chiara R, Marco P, Fiorella A, Danilo D
* Impedance-based drug-resistance characterization of colon cancer cells through real-time cell culture monitoring (82 views)
Talanta (ISSN: 0039-9140linking), 2021 Jan 15; 222: 121441-121441.
Impact Factor: 5.339
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D'Alterio C, Zannetti A, Trotta AM, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S
* New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer (149 views) (PDF 45 views)
Cancers (ISSN: 2072-6694linking), 2020 Jul 18; 12(7): 1952-1952.
Impact Factor: 6.126
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Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
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Mainenti PP, Stanzione A, Guarino S, Romeo V, Ugga L, Romano F, Storto G, Maurea S, Brunetti A
* Colorectal cancer: Parametric evaluation of morphological, functional and molecular tomographic imaging (133 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2019 Sep 21; 25 (35 ): 5233-5256.
Impact Factor: 2.24
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Barresi V, Valenti G, Spampinato G, Musso N, Castorina S, Rizzarelli E, Condorelli DF
* Transcriptome analysis reveals an altered expression profile of zinc transporters in colorectal cancer (185 views)
J Cell Biochem (ISSN: 0730-2312linking), 2018 Dec; 119(12): 9707-9719.
Impact Factor: 2.959
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Pelagalli A, Nardelli A, Lucarelli E, Zannetti A, Brunetti A
* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (659 views)
J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Impact Factor: 5.546
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Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (921 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2018; 61(7): 2910-2923.
Impact Factor: 5.207
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Caprio MG, Simonetti I, Tarotto L, Trovato P, Mainolfi CG, Salvatore B, Pace L
* 18-F-FDG PET, PET/CT AND MDCT IN LOCALLY ADVANCED COLORECTAL CANCER (163 views) (PDF 157 views)
Int J Of Current Res, 2017 Jul; 9: 53960-53964.
Impact Factor: 7.086
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Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (365 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
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Caviglia GP, Cabianca L, Fagoonee S, Gili FM
* Colorectal cancer detection in an asymptomatic population: Fecal immunochemical test for hemoglobin vs. Fecal M2-type pyruvate kinase (329 views)
Biochem Medica (ISSN: 1330-0962), 2016; 26(1): 114-120.
Impact Factor: 2.934
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Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (931 views) (PDF 283 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
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Mainenti PP, Romano F, Pizzuti L, Segreto S, Storto G, Mannelli L, Imbriaco M, Camera L, Maurea S
* Non-invasive diagnostic imaging of colorectal liver metastases (254 views)
World J Radiol (ISSN: 1949-8470electronic, 1949-8470linking), 2015 Jul 28; 7(7): 157-169.
Impact Factor: 0.567
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Calce E, Vitale RM, Scaloni A, Amodeo P, De Luca S
* Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides (597 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; 47(8): 1507-1515.
Impact Factor: 3.196
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Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (528 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
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Greco A, D'Alterio C, Auletta L, Albanese S, Napolitano M, Portella L, Santagata S, Ierano C, Brunetti A, Scala S, Zannetti A
* Longitudinal evaluation with High Frequency Ultrasound imaging of response to CXCR4 new cyclic peptide antagonist with conventional chemotherapy in colorectal cancer mice model (397 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42: S425-S425.
Impact Factor: 5.537
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Napolitano M, D'Alterio C, Cardone E, Trotta AM, Pecori B, Rega D, Pace U, Scala D, Scognamiglio G, Tatangelo F, Cacciapuoti C, Pacelli R, Delrio P, Scala S
* Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients (417 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015; 6(10): 8261-8270.
Impact Factor: 5.008
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (409 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (585 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Napolitano S, Troiani T, Morgillo F, Ciardiello F, Belli G, Cioffi L, Sirignano C, Martinelli E
* Predictive Biomarkers To Anti-Egfr Inhibitors Treatment In The Management Of Metastatic Colorectal Cancer (245 views) (PDF 12 views)
Journal Of Carcinogenesis & Mutagenesis, 2014; N/D: 2157-2518.
Impact Factor: 3.445
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (503 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Giacomobono S, Gallicchio R, Capacchione D, Nardelli A, Gattozzi D, Lettini G, Molinari L, Mainenti P, Cammarota A, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (297 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 2013 Jul 12; 28(12): 1699-1705.
Impact Factor: 2.415
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (672 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (568 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
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Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, De Palma GD, Salvatore M, Pace L
* Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging? (333 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2011 Mar 21; 17(11): 1427-1433.
Impact Factor: 2.471
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (433 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (371 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (410 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Giacomobono S, Capacchione D, Lancellotti M, Nardelli A, Gallicchio R, Improta G, Nappi A, Cammarota A, Di Leo A, Pace L, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (250 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
Impact Factor: 4.531
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Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (733 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (371 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
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Cella L, Ciscognetti N, Martin G, Liuzzi R, Punzo G, Solla R, Farella A, Salvatore M, Pacelli R
* Preoperative Radiation Treatment for Rectal Cancer: Comparison of Target Coverage and Small Bowel NTCP in Conventional vs. 3D-Conformal Planning (486 views)
Med Dosim (ISSN: 0958-3947, 1873-4022), 2009 Mar; 34(1): 75-81.
Impact Factor: 1.256
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Salvatore B, Simeone R, Fonti R, Marciano R, Bianco R, Damiano V, Tortora G, Pace L, Del Vecchio S, Salvatore M
* 18F-FDG PET/CT in the assessment of early response to chemotherapy and molecularly targeted agents in metastatic colorectal cancer (250 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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De Cicco L, Argenone A, Ciscognetti N, Solla R, Farella A, Gaetano M, Punzo G, Cella L, Totaro G, Di Stazio F, Liuzzi R, Pacelli R, Salvatore M
* Effectivenes And Toxicity Of Perioperative Radiation Therapy In Rectal Cancer: Report On 123 Consecutive Cases Of A Single Institution Experience (282 views)
Igrt - Orbi Posters, 2006 Oct; 0: 0-0.
Impact Factor: 0
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Cella L, Punzo G, Martin G, Ciscognetti N, Liuzzi R, Solla R, Farella A, Salvatore M, Pacelli R
* Preoperative radiation treatment for rectal cancer: Comparison of target coverage and small bowel NTCP in conventional versus 3D-conformal planning (352 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2006 Oct; 81: N/D-N/D.
Impact Factor: 3.97
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Caprio MG, Cantalupo T, Mainenti PP, Mainolfi CG, Varrone A, Salvatore B, Persico F, D'Antonio D, Pace L, Salvatore M
* 18F-fdg pet, pet/ct and ce-mdct in locally advanced colorectal cancer (282 views) (PDF 157 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Storto G, Mainenti PP, Varrone A, Mainolfi C, Salvatore B, Caprio MG, Cella L, Soricelli A, Pace L, Salvatore M
* Role of FDG-PET/CT in the staging of colorectal cancer (367 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (377 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
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Mainenti PP, Romano M, Imbriaco M, Camera L, Pace L, D'Antonio D, Bucci L, Galloro G, Salvatore M
* Added value of CT colonography after a positive conventional colonoscopy: Impact on treatment strategy (386 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2005 Jan; 30(1): 42-47.
Impact Factor: 1.034
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (350 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
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Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (383 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (314 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (2682 views)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
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Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using In Vitro and In Vivo Models (3 views)
Acs Appl Mater Interfaces (ISSN: 1944-8252electronic), 2022 Mar 09; 14 (9 ): 11078-11091.
Impact Factor:
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Stanzione A, Verde F, Romeo V, Boccadifuoco F, Mainenti PP, Maurea S
* Radiomics and machine learning applications in rectal cancer: Current update and future perspectives (39 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2021 Aug 28; 27(32): 5306-5321.
Impact Factor: 3.665
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Manco M, Ala U, Cantarella D, Tolosano E, Medico E, Altruda F, Fagoonee S
* The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells (4 views)
Cancers (ISSN: 2072-6694linking), 2021 Aug 13; 13(16): N/D-N/D.
Impact Factor: 6.126
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Susana F, Fagoonee S, Alessandro S, Valentina G, Chiara R, Marco P, Fiorella A, Danilo D
* Impedance-based drug-resistance characterization of colon cancer cells through real-time cell culture monitoring (82 views)
Talanta (ISSN: 0039-9140linking), 2021 Jan 15; 222: 121441-121441.
Impact Factor: 5.339
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D'Alterio C, Zannetti A, Trotta AM, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S
* New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer (149 views) (PDF 45 views)
Cancers (ISSN: 2072-6694linking), 2020 Jul 18; 12(7): 1952-1952.
Impact Factor: 6.126
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Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 16; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
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Mainenti PP, Stanzione A, Guarino S, Romeo V, Ugga L, Romano F, Storto G, Maurea S, Brunetti A
* Colorectal cancer: Parametric evaluation of morphological, functional and molecular tomographic imaging (133 views)
World J Gastroentero (ISSN: 1007-9327linking, 2219-2840), 2019 Sep 21; 25 (35 ): 5233-5256.
Impact Factor: 2.24
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Barresi V, Valenti G, Spampinato G, Musso N, Castorina S, Rizzarelli E, Condorelli DF
* Transcriptome analysis reveals an altered expression profile of zinc transporters in colorectal cancer (185 views)
J Cell Biochem (ISSN: 0730-2312linking), 2018 Dec; 119(12): 9707-9719.
Impact Factor: 2.959
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Pelagalli A, Nardelli A, Lucarelli E, Zannetti A, Brunetti A
* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (659 views)
J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Impact Factor: 5.546
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Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (921 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2018; 61(7): 2910-2923.
Impact Factor: 5.207
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Caprio MG, Simonetti I, Tarotto L, Trovato P, Mainolfi CG, Salvatore B, Pace L
* 18-F-FDG PET, PET/CT AND MDCT IN LOCALLY ADVANCED COLORECTAL CANCER (163 views) (PDF 157 views)
Int J Of Current Res, 2017 Jul; 9: 53960-53964.
Impact Factor: 7.086
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Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (365 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
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Caviglia GP, Cabianca L, Fagoonee S, Gili FM
* Colorectal cancer detection in an asymptomatic population: Fecal immunochemical test for hemoglobin vs. Fecal M2-type pyruvate kinase (329 views)
Biochem Medica (ISSN: 1330-0962), 2016; 26(1): 114-120.
Impact Factor: 2.934
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Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (931 views) (PDF 283 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
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Mainenti PP, Romano F, Pizzuti L, Segreto S, Storto G, Mannelli L, Imbriaco M, Camera L, Maurea S
* Non-invasive diagnostic imaging of colorectal liver metastases (254 views)
World J Radiol (ISSN: 1949-8470electronic, 1949-8470linking), 2015 Jul 28; 7(7): 157-169.
Impact Factor: 0.567
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Calce E, Vitale RM, Scaloni A, Amodeo P, De Luca S
* Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides (597 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; 47(8): 1507-1515.
Impact Factor: 3.196
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Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (528 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
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Greco A, D'Alterio C, Auletta L, Albanese S, Napolitano M, Portella L, Santagata S, Ierano C, Brunetti A, Scala S, Zannetti A
* Longitudinal evaluation with High Frequency Ultrasound imaging of response to CXCR4 new cyclic peptide antagonist with conventional chemotherapy in colorectal cancer mice model (397 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42: S425-S425.
Impact Factor: 5.537
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Napolitano M, D'Alterio C, Cardone E, Trotta AM, Pecori B, Rega D, Pace U, Scala D, Scognamiglio G, Tatangelo F, Cacciapuoti C, Pacelli R, Delrio P, Scala S
* Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients (417 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015; 6(10): 8261-8270.
Impact Factor: 5.008
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (409 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (585 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Napolitano S, Troiani T, Morgillo F, Ciardiello F, Belli G, Cioffi L, Sirignano C, Martinelli E
* Predictive Biomarkers To Anti-Egfr Inhibitors Treatment In The Management Of Metastatic Colorectal Cancer (245 views) (PDF 12 views)
Journal Of Carcinogenesis & Mutagenesis, 2014; N/D: 2157-2518.
Impact Factor: 3.445
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (503 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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Giacomobono S, Gallicchio R, Capacchione D, Nardelli A, Gattozzi D, Lettini G, Molinari L, Mainenti P, Cammarota A, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (297 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 2013 Jul 12; 28(12): 1699-1705.
Impact Factor: 2.415
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Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marf G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R
* Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models (672 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2013 Jan 1; 19(1): 138-147.
Impact Factor: 8.193
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Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (568 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
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Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, De Palma GD, Salvatore M, Pace L
* Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging? (333 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2011 Mar 21; 17(11): 1427-1433.
Impact Factor: 2.471
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (433 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (371 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (410 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Giacomobono S, Capacchione D, Lancellotti M, Nardelli A, Gallicchio R, Improta G, Nappi A, Cammarota A, Di Leo A, Pace L, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (250 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
Impact Factor: 4.531
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Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (733 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (371 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
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Cella L, Ciscognetti N, Martin G, Liuzzi R, Punzo G, Solla R, Farella A, Salvatore M, Pacelli R
* Preoperative Radiation Treatment for Rectal Cancer: Comparison of Target Coverage and Small Bowel NTCP in Conventional vs. 3D-Conformal Planning (486 views)
Med Dosim (ISSN: 0958-3947, 1873-4022), 2009 Mar; 34(1): 75-81.
Impact Factor: 1.256
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Salvatore B, Simeone R, Fonti R, Marciano R, Bianco R, Damiano V, Tortora G, Pace L, Del Vecchio S, Salvatore M
* 18F-FDG PET/CT in the assessment of early response to chemotherapy and molecularly targeted agents in metastatic colorectal cancer (250 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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De Cicco L, Argenone A, Ciscognetti N, Solla R, Farella A, Gaetano M, Punzo G, Cella L, Totaro G, Di Stazio F, Liuzzi R, Pacelli R, Salvatore M
* Effectivenes And Toxicity Of Perioperative Radiation Therapy In Rectal Cancer: Report On 123 Consecutive Cases Of A Single Institution Experience (282 views)
Igrt - Orbi Posters, 2006 Oct; 0: 0-0.
Impact Factor: 0
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Cella L, Punzo G, Martin G, Ciscognetti N, Liuzzi R, Solla R, Farella A, Salvatore M, Pacelli R
* Preoperative radiation treatment for rectal cancer: Comparison of target coverage and small bowel NTCP in conventional versus 3D-conformal planning (352 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2006 Oct; 81: N/D-N/D.
Impact Factor: 3.97
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Caprio MG, Cantalupo T, Mainenti PP, Mainolfi CG, Varrone A, Salvatore B, Persico F, D'Antonio D, Pace L, Salvatore M
* 18F-fdg pet, pet/ct and ce-mdct in locally advanced colorectal cancer (282 views) (PDF 157 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Storto G, Mainenti PP, Varrone A, Mainolfi C, Salvatore B, Caprio MG, Cella L, Soricelli A, Pace L, Salvatore M
* Role of FDG-PET/CT in the staging of colorectal cancer (367 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Sep; 33: N/D-N/D.
Impact Factor: 4.041
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (377 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
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Mainenti PP, Romano M, Imbriaco M, Camera L, Pace L, D'Antonio D, Bucci L, Galloro G, Salvatore M
* Added value of CT colonography after a positive conventional colonoscopy: Impact on treatment strategy (386 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2005 Jan; 30(1): 42-47.
Impact Factor: 1.034
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (350 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
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Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (383 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (314 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (2682 views)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
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47 Records (40 excluding Abstracts).
Total impact factor: 169.599 (144.95 excluding Abstracts).
Total 5 year impact factor: 141.329 (114.299 excluding Abstracts).
Total impact factor: 169.599 (144.95 excluding Abstracts).
Total 5 year impact factor: 141.329 (114.299 excluding Abstracts).
440 views. Last view on Thursday 26 January 2023, 6:29:03
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