Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells (393 views)
J Proteome Res (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.001, 5-year impact factor: 4.894
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874104439&partnerID=40&md5=90ec0f8baeb71a319ded2d781dfef702
Keywords: Arm Repeat, Cancer, Heat Repeat, Hypoxia, Nuclear Export Signal, Nuclear Localization Signal, Carbonate Dehydratase Ix, Exportin 1, Karyopherin, Ubiquitin Protein Ligase, Article, Carboxy Terminal Sequence, Cell Nucleus, Cell Strain Hek293, Cell Surface, Cellular Distribution, Complex Formation, Cytoplasm, Down Regulation, Enzyme Analysis, Enzyme Binding, Enzyme Stability, Gene Overexpression, Genetic Transcription, Human, Hypoxic Cell, Kidney Carcinoma, Kidney Cell, Nucleotide Sequence, Priority Journal, Protein Domain, Protein Function, Protein Localization, Protein Phosphorylation, Protein Protein Interaction, Protein Stability, Protein Targeting, Antigens, Neoplasm, Carbonic Anhydrases, Renal Cell, Cell Hypoxia, Hek293 Cells, Protein Interaction Maps, Transcription Factors,
Affiliations:
*** IBB - CNR ***
CEINGE Biotecnologie Avanzate SCaRL, Naples, Italy
Proteomics and Mass Spectrometry Laboratory, ISPAAM, CNR, Naples, Italy
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universitä di Napoli Federico II, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universitä di Napoli Federico II, Italy
Department of Public Health, Section of Pathology, Seconda Universitä di Napoli, Italy
Dipartimento di Scienze Biomorfologiche e Funzionali, Universitä di Napoli Federico II, Italy
Department of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia
Laboratorio di Chimica Bioinorganica, Universitä di Firenze, Italy
References:
Supuran, C.T., Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators (2008) Nat Rev. Drug Discov., 7 (2), pp. 168-18
Pastorek, J., Pastorekova, S., Callebaut, I., Mornon, J.P., Zelnik, V., Opavsky, R., Zat'ovicova, M., Stanbridge, E.J., Cloning and characterization of MN, a human tumorassociated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment (1994) Oncogene, 9 (10), pp. 2877-2888
Opavsky, R., Pastorekova, S., Zelnik, V., Gibadulinova, A., Stanbridge, E.J., Zavada, J., Kettmann, R., Pastorek, J., Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships (1996) Genomics, 33 (3), pp. 480-487
Hilvo, M., Baranauskiene, L., Salzano, A.M., Scaloni, A., Matulis, D., Innocenti, A., Scozzafava, A., Parkkila, S., Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (2008) J. Biol. Chem., 283 (41), pp. 27799-27809
Alterio, V., Hilvo, M., Di Fiore, A., Supuran, C.T., Pan, P., Parkkila, S., Scaloni, A., De Simone, G., Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (2009) Proc. Natl. Acad. Sci. U.S.A., 106 (38), pp. 16233-16238
Wykoff, C.C., Beasley, N.J., Watson, P.H., Turner, K.J., Pastorek, J., Sibtain, A., Wilson, G.D., Harris, A.L., Hypoxiainducible expression of tumor-associated carbonic anhydrases (2000) Cancer Res., 60 (24), pp. 7075-7083
Potter, C.P., Harris, A.L., Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer (2003) Br. J. Cancer, 89 (1), pp. 2-7
Svastova, E., Hulikova, A., Rafajova, M., Zat'ovicova, M., Gibadulinova, A., Casini, A., Cecchi, A., Pastorekova, S., Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH (2004) FEBS Lett., 577 (3), pp. 439-445
Svastova, E., Witarski, W., Csaderova, L., Kosik, I., Skvarkova, L., Hulikova, A., Zatovicova, M., Pastorekova, S., Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain (2012) J. Biol. Chem., 287 (5), pp. 3392-3402
Swietach, P., Patiar, S., Supuran, C.T., Harris, A.L., Vaughan-Jones, R.D., The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths (2009) J. Biol. Chem., 284 (30), pp. 20299-20310
Pastorekova, S., Parkkila, S., Zavada, J., Tumor-associated carbonic anhydrases and their clinical significance (2006) Adv. Clin. Chem., 42, pp. 167-216
Monti, S.M., Supuran, C.T., De Simone, G., Carbonic anhydrase IX as a target for designing novel anticancer drugs (2012) Curr. Med. Chem., 19 (6), pp. 821-830
Pastorekova, S., Zatovicova, M., Pastorek, J., Cancer-associated carbonic anhydrases and their inhibition (2008) Curr. Pharm. Des., 14 (7), pp. 685-698
Svastova, E., Zilka, N., Zat'ovicova, M., Gibadulinova, A., Ciampor, F., Pastorek, J., Pastorekova, S., Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin (2003) Exp. Cell Res., 290 (2), pp. 332-345
Zavadova, Z., Zavada, J., Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment (2005) Oncol. Rep., 13 (5), pp. 977-982
Zavada, J., Zavadova, Z., Pastorek, J., Biesova, Z., Jezek, J., Velek, J., Human tumour-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion (2000) Br. J. Cancer, 82 (11), pp. 1808-1813
Ditte, P., Dequiedt, F., Svastova, E., Hulikova, A., Ohradanova-Repic, A., Zatovicova, M., Csaderova, L., Pastorek, J., Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors (2011) Cancer Res., 71 (24), pp. 7558-7567
Dorai, T., Sawczuk, I.S., Pastorek, J., Wiernik, P.H., Dutcher, J.P., The role of carbonic anhydrase IX overexpression in kidney cancer (2005) Eur. J. Cancer, 41 (18), pp. 2935-2947
Caratu, G., Allegra, D., Bimonte, M., Schiattarella, G.G., D'ambrosio, C., Scaloni, A., Napolitano, M., Zambrano, N., Identification of the ligands of protein interaction domains through a functional approach (2007) Mol. Cell. Proteomics, 6 (2), pp. 333-345
Shevchenko, A., Wilm, M., Vorm, O., Mann, M., Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels (1996) Anal. Chem., 68 (5), pp. 850-858
Gallo, G., Renzone, G., Alduina, R., Stegmann, E., Weber, T., Lantz, A.E., Thykaer, J., Puglia, A.M., Differential proteomic analysis reveals novel links between primary metabolism and antibiotic production in Amycolatopsis balhimycina (2010) Proteomics, 10 (7), pp. 1336-1358
Vitale, M., Renzone, G., Matsuda, S., Scaloni, A., D'adamio, L., Zambrano, N., Proteomic characterization of a mouse model of familial danish dementia (2012) J. Biomed. Biotechnol., p. 728178
Picariello, G., Ferranti, P., Mamone, G., Roepstorff, P., Addeo, F., Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry (2008) Proteomics, 8 (18), pp. 3833-3847
D'ambrosio, C., Arena, S., Salzano, A.M., Renzone, G., Ledda, L., Scaloni, A., A proteomic characterization of water buffalo milk fractions describing PTM of major species and the identification of minor components involved in nutrient delivery and defense against pathogens (2008) Proteomics, 8 (17), pp. 3657-3666
Arena, S., Renzone, G., Novi, G., Paffetti, A., Bernardini, G., Santucci, A., Scaloni, A., Modern proteomic methodologies for the characterization of lactosylation protein targets in milk (2010) Proteomics, 10 (19), pp. 3414-3434
Szklarczyk, D., Franceschini, A., Kuhn, M., Simonovic, M., Roth, A., Minguez, P., Doerks, T., Von Mering, C., The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored (2011) Nucleic Acids Res., 39, pp. D561-D568
Huang Da, W., Sherman, B.T., Lempicki, R.A., Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources (2009) Nat. Protoc., 4 (1), pp. 44-57
Zat'ovicova, M., Tarabkova, K., Svastova, E., Gibadulinova, A., Mucha, V., Jakubickova, L., Biesova, Z., Pastorekova, S., Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumourassociated hypoxia-induced carbonic anhydrase IX (2003) J. Immunol. Methods, 282 (1-2), pp. 117-134
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35 (3), pp. 161-214
Prigent, M., Barlat, I., Langen, H., Dargemont, C., IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2 (2000) J. Biol. Chem., 275 (46), pp. 36441-36449
Andrade, M.A., Petosa, C., O'donoghue, S.I., Muller, C.W., Bork, P., Comparison of ARM and HEAT protein repeats (2001) J. Mol. Biol., 309 (1), pp. 1-18
Henderson, B.R., Eleftheriou, A., A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals (2000) Exp. Cell Res., 256 (1), pp. 213-224
Lee, B.J., Cansizoglu, A.E., Suel, K.E., Louis, T.H., Zhang, Z., Chook, Y.M., Rules for nuclear localization sequence recognition by karyopherin beta 2 (2006) Cell, 126 (3), pp. 543-558
Swinson, D.E., Jones, J.L., Richardson, D., Wykoff, C., Turley, H., Pastorek, J., Taub, N., O'byrne, K.J., Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer (2003) J. Clin. Oncol., 21 (3), pp. 473-482
Dungwa, J.V., Hunt, L.P., Ramani, P., Carbonic anhydrase IX up-regulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas (2012) Hum. Pathol., 43 (10), pp. 1651-1660
Bikkavilli, R.K., Malbon, C.C., Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2 (2012) J. Cell Sci., 125 (10), pp. 2446-2456
Campbell, M.G., Karbstein, K., Protein-protein interactions within late pre-40S ribosomes (2011) PLoS One, 6 (1), pp. e16194
Lee, J.E., Sweredoski, M.J., Graham, R.L., Kolawa, N.J., Smith, G.T., Hess, S., Deshaies, R.J., The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation (2011) Mol. Cell. Proteomics, 10 (5), pp. M110006460
Giri, D.K., Ali-Seyed, M., Li, L.Y., Lee, D.F., Ling, P., Bartholomeusz, G., Wang, S.C., Hung, M.C., Endosomal transport of ErbB-2: Mechanism for nuclear entry of the cell surface receptor (2005) Mol. Cell. Biol., 25 (24), pp. 11005-11018
Bryant, D.M., Stow, J.L., Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor (2005) Traffic, 6 (10), pp. 947-954
Janiszewska, M., De Vito, C., Le Bitoux, M.A., Fusco, C., Stamenkovic, I., Transportin regulates nuclear import of CD44 (2010) J. Biol. Chem., 285 (40), pp. 30548-30557
Zatovicova, M., Jelenska, L., Hulikova, A., Csaderova, L., Ditte, Z., Ditte, P., Goliasova, T., Pastorekova, S., Carbonic anhydrase IX as an anticancer therapy target: Preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain (2010) Curr. Pharm. Des., 16 (29), pp. 3255-3263
Makino, Y., Yogosawa, S., Kayukawa, K., Coin, F., Egly, J.M., Wang, Z., Roeder, R.G., Tamura, T., TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism (1999) Mol. Cell. Biol., 19 (12), pp. 7951-7960
Aoki, T., Okada, N., Wakamatsu, T., Tamura, T.A., TBPinteracting protein 120B, which is induced in relation to myogenesis, binds to NOT3 (2002) Biochem. Biophys. Res. Commun., 296 (5), pp. 1097-1103
Duda, D.M., Scott, D.C., Calabrese, M.F., Zimmerman, E.S., Zheng, N., Schulman, B.A., Structural regulation of cullin-RING ubiquitin ligase complexes (2011) Curr. Opin. Struct. Biol., 21 (2), pp. 257-264
Shiraishi, S., Zhou, C., Aoki, T., Sato, N., Chiba, T., Tanaka, K., Yoshida, S., Tamura, T.A., TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation (2007) J. Biol. Chem., 282 (12), pp. 9017-9028
Turner, J.G., Dawson, J., Sullivan, D.M., Nuclear export of proteins and drug resistance in cancer (2012) Biochem. Pharmacol., 83 (8), pp. 1021-1032
Zemp, I., Kutay, U., Nuclear export and cytoplasmic maturation of ribosomal subunits (2007) FEBS Lett., 581 (15), pp. 2783-2793
Groulx, I., Lee, S., Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein (2002) Mol. Cell. Biol., 22 (15), pp. 5319-5336
Steinhoff, A., Pientka, F.K., Mockel, S., Kettelhake, A., Hartmann, E., Kohler, M., Depping, R., Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2 (2009) Biochem. Biophys. Res. Commun., 387 (4), pp. 705-711
Mylonis, I., Chachami, G., Samiotaki, M., Panayotou, G., Paraskeva, E., Kalousi, A., Georgatsou, E., Simos, G., Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha (2006) J. Biol. Chem., 281 (44), pp. 33095-33106
Koritzinsky, M., Wouters, B.G., Hypoxia and regulation of messenger RNA translation (2007) Methods Enzymol., 435, pp. 247-273
Supuran, C. T., Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators (2008) Nat Rev. Drug Discov., 7 (2), pp. 168-18
Wykoff, C. C., Beasley, N. J., Watson, P. H., Turner, K. J., Pastorek, J., Sibtain, A., Wilson, G. D., Harris, A. L., Hypoxiainducible expression of tumor-associated carbonic anhydrases (2000) Cancer Res., 60 (24), pp. 7075-7083
Potter, C. P., Harris, A. L., Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer (2003) Br. J. Cancer, 89 (1), pp. 2-7
Monti, S. M., Supuran, C. T., De Simone, G., Carbonic anhydrase IX as a target for designing novel anticancer drugs (2012) Curr. Med. Chem., 19 (6), pp. 821-830
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int. J. Pept. Protein Res., 35 (3), pp. 161-214
Andrade, M. A., Petosa, C., O'donoghue, S. I., Muller, C. W., Bork, P., Comparison of ARM and HEAT protein repeats (2001) J. Mol. Biol., 309 (1), pp. 1-18
Henderson, B. R., Eleftheriou, A., A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals (2000) Exp. Cell Res., 256 (1), pp. 213-224
Lee, B. J., Cansizoglu, A. E., Suel, K. E., Louis, T. H., Zhang, Z., Chook, Y. M., Rules for nuclear localization sequence recognition by karyopherin beta 2 (2006) Cell, 126 (3), pp. 543-558
Swinson, D. E., Jones, J. L., Richardson, D., Wykoff, C., Turley, H., Pastorek, J., Taub, N., O'byrne, K. J., Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer (2003) J. Clin. Oncol., 21 (3), pp. 473-482
Dungwa, J. V., Hunt, L. P., Ramani, P., Carbonic anhydrase IX up-regulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas (2012) Hum. Pathol., 43 (10), pp. 1651-1660
Bikkavilli, R. K., Malbon, C. C., Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2 (2012) J. Cell Sci., 125 (10), pp. 2446-2456
Campbell, M. G., Karbstein, K., Protein-protein interactions within late pre-40S ribosomes (2011) PLoS One, 6 (1), pp. e16194
Lee, J. E., Sweredoski, M. J., Graham, R. L., Kolawa, N. J., Smith, G. T., Hess, S., Deshaies, R. J., The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation (2011) Mol. Cell. Proteomics, 10 (5), pp. M110006460
Giri, D. K., Ali-Seyed, M., Li, L. Y., Lee, D. F., Ling, P., Bartholomeusz, G., Wang, S. C., Hung, M. C., Endosomal transport of ErbB-2: Mechanism for nuclear entry of the cell surface receptor (2005) Mol. Cell. Biol., 25 (24), pp. 11005-11018
Bryant, D. M., Stow, J. L., Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor (2005) Traffic, 6 (10), pp. 947-954
Duda, D. M., Scott, D. C., Calabrese, M. F., Zimmerman, E. S., Zheng, N., Schulman, B. A., Structural regulation of cullin-RING ubiquitin ligase complexes (2011) Curr. Opin. Struct. Biol., 21 (2), pp. 257-264
Turner, J. G., Dawson, J., Sullivan, D. M., Nuclear export of proteins and drug resistance in cancer (2012) Biochem. Pharmacol., 83 (8), pp. 1021-1032
J Proteome Res (ISSN: 1535-3893), 2013 Jan; 12(1): 282-292.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.001, 5-year impact factor: 4.894
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874104439&partnerID=40&md5=90ec0f8baeb71a319ded2d781dfef702
Keywords: Arm Repeat, Cancer, Heat Repeat, Hypoxia, Nuclear Export Signal, Nuclear Localization Signal, Carbonate Dehydratase Ix, Exportin 1, Karyopherin, Ubiquitin Protein Ligase, Article, Carboxy Terminal Sequence, Cell Nucleus, Cell Strain Hek293, Cell Surface, Cellular Distribution, Complex Formation, Cytoplasm, Down Regulation, Enzyme Analysis, Enzyme Binding, Enzyme Stability, Gene Overexpression, Genetic Transcription, Human, Hypoxic Cell, Kidney Carcinoma, Kidney Cell, Nucleotide Sequence, Priority Journal, Protein Domain, Protein Function, Protein Localization, Protein Phosphorylation, Protein Protein Interaction, Protein Stability, Protein Targeting, Antigens, Neoplasm, Carbonic Anhydrases, Renal Cell, Cell Hypoxia, Hek293 Cells, Protein Interaction Maps, Transcription Factors,
Affiliations:
*** IBB - CNR ***
CEINGE Biotecnologie Avanzate SCaRL, Naples, Italy
Proteomics and Mass Spectrometry Laboratory, ISPAAM, CNR, Naples, Italy
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universitä di Napoli Federico II, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universitä di Napoli Federico II, Italy
Department of Public Health, Section of Pathology, Seconda Universitä di Napoli, Italy
Dipartimento di Scienze Biomorfologiche e Funzionali, Universitä di Napoli Federico II, Italy
Department of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia
Laboratorio di Chimica Bioinorganica, Universitä di Firenze, Italy
References:
Supuran, C.T., Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators (2008) Nat Rev. Drug Discov., 7 (2), pp. 168-18
Pastorek, J., Pastorekova, S., Callebaut, I., Mornon, J.P., Zelnik, V., Opavsky, R., Zat'ovicova, M., Stanbridge, E.J., Cloning and characterization of MN, a human tumorassociated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment (1994) Oncogene, 9 (10), pp. 2877-2888
Opavsky, R., Pastorekova, S., Zelnik, V., Gibadulinova, A., Stanbridge, E.J., Zavada, J., Kettmann, R., Pastorek, J., Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships (1996) Genomics, 33 (3), pp. 480-487
Hilvo, M., Baranauskiene, L., Salzano, A.M., Scaloni, A., Matulis, D., Innocenti, A., Scozzafava, A., Parkkila, S., Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (2008) J. Biol. Chem., 283 (41), pp. 27799-27809
Alterio, V., Hilvo, M., Di Fiore, A., Supuran, C.T., Pan, P., Parkkila, S., Scaloni, A., De Simone, G., Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (2009) Proc. Natl. Acad. Sci. U.S.A., 106 (38), pp. 16233-16238
Wykoff, C.C., Beasley, N.J., Watson, P.H., Turner, K.J., Pastorek, J., Sibtain, A., Wilson, G.D., Harris, A.L., Hypoxiainducible expression of tumor-associated carbonic anhydrases (2000) Cancer Res., 60 (24), pp. 7075-7083
Potter, C.P., Harris, A.L., Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer (2003) Br. J. Cancer, 89 (1), pp. 2-7
Svastova, E., Hulikova, A., Rafajova, M., Zat'ovicova, M., Gibadulinova, A., Casini, A., Cecchi, A., Pastorekova, S., Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH (2004) FEBS Lett., 577 (3), pp. 439-445
Svastova, E., Witarski, W., Csaderova, L., Kosik, I., Skvarkova, L., Hulikova, A., Zatovicova, M., Pastorekova, S., Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain (2012) J. Biol. Chem., 287 (5), pp. 3392-3402
Swietach, P., Patiar, S., Supuran, C.T., Harris, A.L., Vaughan-Jones, R.D., The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths (2009) J. Biol. Chem., 284 (30), pp. 20299-20310
Pastorekova, S., Parkkila, S., Zavada, J., Tumor-associated carbonic anhydrases and their clinical significance (2006) Adv. Clin. Chem., 42, pp. 167-216
Monti, S.M., Supuran, C.T., De Simone, G., Carbonic anhydrase IX as a target for designing novel anticancer drugs (2012) Curr. Med. Chem., 19 (6), pp. 821-830
Pastorekova, S., Zatovicova, M., Pastorek, J., Cancer-associated carbonic anhydrases and their inhibition (2008) Curr. Pharm. Des., 14 (7), pp. 685-698
Svastova, E., Zilka, N., Zat'ovicova, M., Gibadulinova, A., Ciampor, F., Pastorek, J., Pastorekova, S., Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin (2003) Exp. Cell Res., 290 (2), pp. 332-345
Zavadova, Z., Zavada, J., Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment (2005) Oncol. Rep., 13 (5), pp. 977-982
Zavada, J., Zavadova, Z., Pastorek, J., Biesova, Z., Jezek, J., Velek, J., Human tumour-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion (2000) Br. J. Cancer, 82 (11), pp. 1808-1813
Ditte, P., Dequiedt, F., Svastova, E., Hulikova, A., Ohradanova-Repic, A., Zatovicova, M., Csaderova, L., Pastorek, J., Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors (2011) Cancer Res., 71 (24), pp. 7558-7567
Dorai, T., Sawczuk, I.S., Pastorek, J., Wiernik, P.H., Dutcher, J.P., The role of carbonic anhydrase IX overexpression in kidney cancer (2005) Eur. J. Cancer, 41 (18), pp. 2935-2947
Caratu, G., Allegra, D., Bimonte, M., Schiattarella, G.G., D'ambrosio, C., Scaloni, A., Napolitano, M., Zambrano, N., Identification of the ligands of protein interaction domains through a functional approach (2007) Mol. Cell. Proteomics, 6 (2), pp. 333-345
Shevchenko, A., Wilm, M., Vorm, O., Mann, M., Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels (1996) Anal. Chem., 68 (5), pp. 850-858
Gallo, G., Renzone, G., Alduina, R., Stegmann, E., Weber, T., Lantz, A.E., Thykaer, J., Puglia, A.M., Differential proteomic analysis reveals novel links between primary metabolism and antibiotic production in Amycolatopsis balhimycina (2010) Proteomics, 10 (7), pp. 1336-1358
Vitale, M., Renzone, G., Matsuda, S., Scaloni, A., D'adamio, L., Zambrano, N., Proteomic characterization of a mouse model of familial danish dementia (2012) J. Biomed. Biotechnol., p. 728178
Picariello, G., Ferranti, P., Mamone, G., Roepstorff, P., Addeo, F., Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry (2008) Proteomics, 8 (18), pp. 3833-3847
D'ambrosio, C., Arena, S., Salzano, A.M., Renzone, G., Ledda, L., Scaloni, A., A proteomic characterization of water buffalo milk fractions describing PTM of major species and the identification of minor components involved in nutrient delivery and defense against pathogens (2008) Proteomics, 8 (17), pp. 3657-3666
Arena, S., Renzone, G., Novi, G., Paffetti, A., Bernardini, G., Santucci, A., Scaloni, A., Modern proteomic methodologies for the characterization of lactosylation protein targets in milk (2010) Proteomics, 10 (19), pp. 3414-3434
Szklarczyk, D., Franceschini, A., Kuhn, M., Simonovic, M., Roth, A., Minguez, P., Doerks, T., Von Mering, C., The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored (2011) Nucleic Acids Res., 39, pp. D561-D568
Huang Da, W., Sherman, B.T., Lempicki, R.A., Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources (2009) Nat. Protoc., 4 (1), pp. 44-57
Zat'ovicova, M., Tarabkova, K., Svastova, E., Gibadulinova, A., Mucha, V., Jakubickova, L., Biesova, Z., Pastorekova, S., Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumourassociated hypoxia-induced carbonic anhydrase IX (2003) J. Immunol. Methods, 282 (1-2), pp. 117-134
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Andrade, M. A., Petosa, C., O'donoghue, S. I., Muller, C. W., Bork, P., Comparison of ARM and HEAT protein repeats (2001) J. Mol. Biol., 309 (1), pp. 1-18
Henderson, B. R., Eleftheriou, A., A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals (2000) Exp. Cell Res., 256 (1), pp. 213-224
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Dungwa, J. V., Hunt, L. P., Ramani, P., Carbonic anhydrase IX up-regulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas (2012) Hum. Pathol., 43 (10), pp. 1651-1660
Bikkavilli, R. K., Malbon, C. C., Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2 (2012) J. Cell Sci., 125 (10), pp. 2446-2456
Campbell, M. G., Karbstein, K., Protein-protein interactions within late pre-40S ribosomes (2011) PLoS One, 6 (1), pp. e16194
Lee, J. E., Sweredoski, M. J., Graham, R. L., Kolawa, N. J., Smith, G. T., Hess, S., Deshaies, R. J., The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation (2011) Mol. Cell. Proteomics, 10 (5), pp. M110006460
Giri, D. K., Ali-Seyed, M., Li, L. Y., Lee, D. F., Ling, P., Bartholomeusz, G., Wang, S. C., Hung, M. C., Endosomal transport of ErbB-2: Mechanism for nuclear entry of the cell surface receptor (2005) Mol. Cell. Biol., 25 (24), pp. 11005-11018
Bryant, D. M., Stow, J. L., Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor (2005) Traffic, 6 (10), pp. 947-954
Duda, D. M., Scott, D. C., Calabrese, M. F., Zimmerman, E. S., Zheng, N., Schulman, B. A., Structural regulation of cullin-RING ubiquitin ligase complexes (2011) Curr. Opin. Struct. Biol., 21 (2), pp. 257-264
Turner, J. G., Dawson, J., Sullivan, D. M., Nuclear export of proteins and drug resistance in cancer (2012) Biochem. Pharmacol., 83 (8), pp. 1021-1032
Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells
Carbonic anhydrase IX (CA IX) is a transmembrane protein affecting pH regulation, cell migration/invasion, and survival in hypoxic tumors. Although the pathways related to CA IX have begun to emerge, molecular partners mediating its functions remain largely unknown. Here we characterize the CA IX interactome in hypoxic HEK-293 cells. Most of the identified CA IX-binding partners contain the HEAT/ARM repeat domain and belong to the nuclear transport machinery. We show that the interaction with two of these proteins, namely XPO1 exportin and TNPO1 importin, occurs via the C-terminal region of CA IX and increases with protein phosphorylation. We also demonstrate that nuclear CA IX is enriched in hypoxic cells and is present in renal cell carcinoma tissues. These data place CA IX among the cell-surface signal transducers undergoing nuclear translocation. Accordingly, CA IX interactome involves also CAND1, which participates in both gene transcription and assembly of SCF ubiquitin ligase complexes. It is noteworthy that down-regulation of CAND1 leads to decreased CA IX protein levels apparently via affecting its stability. Our findings provide the first evidence that CA IX interacts with proteins involved in nuclear/cytoplasmic transport, gene transcription, and protein stability, and suggest the existence of nuclear CA IX protein subpopulations with a potential intracellular function, distinct from the crucial CA IX role at the cell surface. © 2012 American Chemical Society.
Carbonic anhydrase IX (CA IX) is a transmembrane protein affecting pH regulation, cell migration/invasion, and survival in hypoxic tumors. Although the pathways related to CA IX have begun to emerge, molecular partners mediating its functions remain largely unknown. Here we characterize the CA IX interactome in hypoxic HEK-293 cells. Most of the identified CA IX-binding partners contain the HEAT/ARM repeat domain and belong to the nuclear transport machinery. We show that the interaction with two of these proteins, namely XPO1 exportin and TNPO1 importin, occurs via the C-terminal region of CA IX and increases with protein phosphorylation. We also demonstrate that nuclear CA IX is enriched in hypoxic cells and is present in renal cell carcinoma tissues. These data place CA IX among the cell-surface signal transducers undergoing nuclear translocation. Accordingly, CA IX interactome involves also CAND1, which participates in both gene transcription and assembly of SCF ubiquitin ligase complexes. It is noteworthy that down-regulation of CAND1 leads to decreased CA IX protein levels apparently via affecting its stability. Our findings provide the first evidence that CA IX interacts with proteins involved in nuclear/cytoplasmic transport, gene transcription, and protein stability, and suggest the existence of nuclear CA IX protein subpopulations with a potential intracellular function, distinct from the crucial CA IX role at the cell surface. © 2012 American Chemical Society.
Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells
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Characterization of carbonic anhydrase ix interactome reveals proteins assisting its nuclear localization in hypoxic cells
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Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (532 views)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
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Monti SM, Supuran CT, De Simone G
* DPP-4 inhibitors: a patent review (2012 - 2014) (573 views)
Expert Opin Ther Pat (ISSN: 1354-3776, 1744-7674electronic), 2015 Feb; 25(2): 209-236.
Impact Factor: 4.626
View Export to BibTeX Export to EndNote
Monti SM, Supuran CT, De Simone G
* Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013) (468 views)
Expert Opin Ther Pat (ISSN: 1354-3776, 1744-7674electronic), 2013 Jun; 23(6): 737-749.
Impact Factor: 3.441
View Export to BibTeX Export to EndNote
Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (526 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
Impact Factor: 4.07
View Export to BibTeX Export to EndNote
De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (398 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G
* Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (571 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Sep 22; 106(38): 16233-16238.
Impact Factor: 9.432
View Export to BibTeX Export to EndNote
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (532 views)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
View Export to BibTeX Export to EndNote
Monti SM, Supuran CT, De Simone G
* DPP-4 inhibitors: a patent review (2012 - 2014) (573 views)
Expert Opin Ther Pat (ISSN: 1354-3776, 1744-7674electronic), 2015 Feb; 25(2): 209-236.
Impact Factor: 4.626
View Export to BibTeX Export to EndNote
Monti SM, Supuran CT, De Simone G
* Anticancer carbonic anhydrase inhibitors: A patent review (2008-2013) (468 views)
Expert Opin Ther Pat (ISSN: 1354-3776, 1744-7674electronic), 2013 Jun; 23(6): 737-749.
Impact Factor: 3.441
View Export to BibTeX Export to EndNote
Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (526 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
Impact Factor: 4.07
View Export to BibTeX Export to EndNote
De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (398 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G
* Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (571 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Sep 22; 106(38): 16233-16238.
Impact Factor: 9.432
View Export to BibTeX Export to EndNote
6 Records (6 excluding Abstracts).
Total impact factor: 32.632 (32.632 excluding Abstracts).
Total 5 year impact factor: 24.047 (24.047 excluding Abstracts).
Total impact factor: 32.632 (32.632 excluding Abstracts).
Total 5 year impact factor: 24.047 (24.047 excluding Abstracts).
393 views. Last view on Tuesday 21 March 2023, 16:09:55
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