Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Naples, Italy
Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy
Universit degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy
References: Supuran, C.T., Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators (2008) Nature Reviews Drug Discovery, 7 (2), pp. 168-181. , DOI 10.1038/nrd2467, PII NRD246
Krishnamurthy, V.M., Kaufman, G.K., Urbach, A.R., Gitlin, I., Gudiksen, K.L., Weibel, D.B., Whitesides, G.M., Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding (2008) Chemical Reviews, 108 (3), pp. 946-1051. , DOI 10.1021/cr050262p
Supuran, C.T., Winum, J.-Y., (2009) Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications, (PART II). , Wiley: Hoboken, New Jersey
Supuran, C.T., Scozzafava, A., Conway, J., (2004) Carbonic Anhydrase: Its Inhibitors and Activators, , CRC Press: Boca Raton, FL
Maren, T.H., Carbonic anhydrase: Chemistry, physiology, and inhibition (1967) Physiol. Rev., 47, pp. 595-781
Pastorek, J., Pastoreková, S., Callebaut, I., Mornon, J.P., Zelník, V., Opavsk, R., Zat'ovicová, M., Kettmann, R., Cloning and characterization of MN, a human tumor-Associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment (1994) Oncogene, 9, pp. 2877-2888
Opavsky, R., Pastorekova, S., Zelnik, V., Gibadulinova, A., Stanbridge, E.J., Zavada, J., Kettmann, R., Pastorek, J., Human MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships (1996) Genomics, 33 (3), pp. 480-487. , DOI 10.1006/geno.1996.0223
Supuran, C.T., Di Fiore, A., Alterio, V., Monti, S.M., De Simone, G., Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII (2010) Curr. Pharm. Des., 16, pp. 3246-3254
De Simone, G., Supuran, C.T., Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (1804) Biochim. Biophys. Acta, 2010, pp. 404-409
Guler, O.O., De Simone, G., Supuran, C.T., Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (2010) Curr. Med. Chem., 17, pp. 1516-1526
Zatovicova, M., Jelenska, L., Hulikova, A., Csaderova, L., Ditte, Z., Ditte, P., Goliasova, T., Pastorekova, S., Carbonic anhydrase IX as an anticancer therapy target: Preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain (2010) Curr. Pharm. Des., 16, pp. 3255-3263
Pastorekova, S., Zatovicova, M., Pastorek, J., Cancer-associated carbonic anhydrases and their inhibition (2008) Current Pharmaceutical Design, 14 (7), pp. 685-698. , http://www.ingentaconnect.com/content/ben/cpd/2008/00000014/00000007/ art00012, DOI 10.2174/138161208783877893
Pastoreková, S., Závadová, Z., Kostál, M., Babusíková, O., Závada, J., A novel quasi-viral agent, MaTu, is a two-component system (1992) Virology, 187, pp. 620-626
Pastorekova, S., Parkkila, S., Parkkila, A.-K., Opavsky, R., Zelnik, V., Saarnio, J., Pastorek, J., Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts (1997) Gastroenterology, 112 (2), pp. 398-408. , DOI 10.1053/gast.1997.v112.pm9024293
Saarnio, J., Parkkila, S., Parkkila, A.K., Waheed, A., Casey, M.C., Zhou, X.Y., Pastoreková, S., Sly, W.S., Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation (1998) J. Histochem. Cytochem., 46, pp. 497-504
Stillebroer, A.B., Mulders, P.F., Boerman, O.C., Oyen, W.J., Oosterwijk, E., Carbonic anhydrase IX in renal cell carcinoma: Implications for prognosis, diagnosis, and therapy (2010) Eur. Urol., 58, pp. 75-83
Pastoreková, S., Pastorek, J., (2004) Carbonic Anhydrase: Its Inhibitors and Activators, pp. 255-281. , Supuran, C.T.
-CRC Press. Boca Raton, FL
Barnea, G., Grumet, M., Milev, P., Silvennoinen, O., Levy, J.B., Sap, J., Schlessinger, J., Receptor tyrosine phosphatase β is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin (1994) Journal of Biological Chemistry, 269 (20), pp. 14349-14352
Peles, E., Nativ, M., Campbell, P.L., Sakurai, T., Martinez, R., Lev, S., Clary, D.O., Schlessinger, J., The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin (1995) Cell, 82, pp. 251-260
Parent, A.S., Mungenast, A.E., Lomniczi, A., Sandau, U.S., Peles, E., Bosch, M.A., Rønnekleiv, O.K., Ojeda, S.R., A contactin-receptor-like protein tyrosine phosphatase beta complex mediates adhesive communication between astroglial cells and gonadotrophin-releasing hormone neurones (2007) J. Neuroendocrinol., 19, pp. 847-859
Hilvo, M., Baranauskiene, L., Salzano, A.M., Scaloni, A., Matulis, D., Innocenti, A., Scozzafava, A., Parkkila, S., Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (2008) J. Biol. Chem., 283, pp. 27799-27809
Funderburgh, J.L., Keratan sulfate: Structure, biosynthesis, and function (2000) Glycobiology, 10, pp. 951-958
Dorai, T., Sawczuk, I.S., Pastorek, J., Wiernik, P.H., Dutcher, J.P., The role of carbonic anhydrase IX overexpression in kidney cancer (2005) European Journal of Cancer, 41 (18), pp. 2935-2947. , DOI 10.1016/j.ejca.2005.09.011, PII S0959804905008415
Wingo, T., Tu, C., Laipis, P.J., Silverman, D.N., The catalytic properties of human carbonic anhydrase IX (2001) Biochemical and Biophysical Research Communications, 288 (3), pp. 666-669. , DOI 10.1006/bbrc.2001.5824
Innocenti, A., Pastorekova, S., Pastorek, J., Scozzafava, A., De Simone, G., Supuran, C.T., The proteoglycan region of the tumor-Associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO 2 hydration at acidic pH values characteristic of solid tumors (2009) Bioorg Med Chem Lett., 19, pp. 5825-5828
Alterio, V., Hilvo, M., Di Fiore, A., Supuran, C.T., Pan, P., Parkkila, S., Scaloni, A., De Simone, G., Crystal structure of the catalytic domain of the tumorassociated human carbonic anhydrase IX (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 16233-16238
Maxwell, P.H., Wlesener, M.S., Chang, G.-W., Clifford, S.C., Vaux, E.C., Cockman, M.E., Wykoff, C.C., Ratcliffe, P.J., The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis (1999) Nature, 399 (6733), pp. 271-275. , DOI 10.1038/20459
Huang, L.E., Bunn, H.F., Hypoxia-inducible factor and its biomedical relevance (2003) Journal of Biological Chemistry, 278 (22), pp. 19575-19578. , DOI 10.1074/jbc.R200030200
Coleman, M.L., Ratcliffe, P.J., Oxygen sensing and hypoxia-induced responses (2007) Essays Biochem., 43, pp. 1-15
Wykoff, C.C., Beasley, N.J.P., Watson, P.H., Turner, K.J., Pastorek, J., Sibtain, A., Wilson, G.D., Ratcliffe, P.J., Hypoxia-inducible expression of tumor-associated carbonic anhydrases (2000) Cancer Research, 60 (24), pp. 7075-7083
Pastorekova, S., Barathova, M., Kopacek, J., Pastorek, J., (2009) Drug Design of Zinc-Enzyme Inhibitors: Functional Structural and Disease Applications, pp. 193-222. , Supuran C. T.
Stubbs, M., McSheehy, P.M.J., Griffiths, J.R., Bashford, C.L., Causes and consequences of tumour acidity and implications for treatment (2000) Molecular Medicine Today, 6 (1), pp. 15-19. , DOI 10.1016/S1357-4310(99)01615-9, PII S1357431099016159
Helmlinger, G., Sckell, A., Dellian, M., Forbes, N.S., Jain, R.K., Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism (2002) Clinical Cancer Research, 8 (4), pp. 1284-1291
Fukumura, D., Jain, R.K., Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize (2007) Journal of Cellular Biochemistry, 101 (4), pp. 937-949. , DOI 10.1002/jcb.21187
Swietach, P., Hulikova, A., Vaughan-Jones, R.D., Harris, A.L., New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation (2010) Oncogene, 29, pp. 6509-6521
Martinez-Zaguilan, R., Lynch, R.M., Martinez, G.M., Gillies, R.J., Vacuolartype H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells (1993) Am. J. Physiol., 265, pp. C1015-C1029
Lee, A.H., Tannock, I.F., Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells (1998) Cancer Research, 58 (9), pp. 1901-1908
McLean, L.A., Roscoe, J., Jorgensen, N.K., Gorin, F.A., Cala, P.M., Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes (2000) American Journal of Physiology - Cell Physiology, 278 (4-47), pp. C676-C688
Boron, W.F., Regulation of intracellular pH (2004) Adv. Physiol. Educ., 28, pp. 160-179
Chiche, J., Brahimi-Horn, M.C., Pouysségur, J., Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer (2010) J. Cell. Mol. Med., 14, pp. 771-794
Swietach, P., Vaughan-Jones, R.D., Harris, A.L., Regulation of tumor pH and the role of carbonic anhydrase 9 (2007) Cancer and Metastasis Reviews, 26 (2), pp. 299-310. , DOI 10.1007/s10555-007-9064-0, Special issue on Hypoxia and Cancer, Guest Editor: Gregg L. Semenza
Morgan, P.E., Pastorekova, S., Stuart-Tilley, A.K., Alper, S.L., Casey, J.R., Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters (2007) American Journal of Physiology - Cell Physiology, 293 (2), pp. C738-C748. , http://ajpcell.physiology.org/cgi/reprint/293/2/C738, DOI 10.1152/ajpcell.00157.2007
Svastova, E., Hulikova, A., Rafajova, M., Zat'Ovicova, M., Gibadulinova, A., Casini, A., Cecchi, A., Pastorekova, S., Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH (2004) FEBS Letters, 577 (3), pp. 439-445. , DOI 10.1016/j.febslet.2004.10.043, PII S0014579304012943
Swietach, P., Patiar, S., Supuran, C.T., Harris, A.L., Vaughan-Jones, R.D., The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in three-dimensional tumor cell growths (2009) J. Biol. Chem., 284, pp. 20299-20310
Casey, J.R., Why bicarbonate? (2006) Biochemistry and Cell Biology, 84 (6), pp. 930-939. , DOI 10.1139/O06-184
Cecchi, A., Hulikova, A., Pastorek, J., Pastorekova, S., Scozzafava, A., Winum, J.-Y., Montero, J.-L., Supuran, C.T., Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors (2005) Journal of Medicinal Chemistry, 48 (15), pp. 4834-4841. , DOI 10.1021/jm0501073
Dubois, L., Douma, K., Supuran, C.T., Chiu, R.K., Van Zandvoort, M.A.M.J., Pastorekova, S., Scozzafava, A., Lambin, P., Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors (2007) Radiotherapy and Oncology, 83 (3), pp. 367-373. , DOI 10.1016/j.radonc.2007.04.018, PII S0167814007001752, Highlights from the 10th International ESTRO-Wolfsberg Meeting on Molecular Radiation Biology/Oncology 2007
Svastova, E., Zilka, N., Zat'ovicova, M., Gibadulinova, A., Ciampor, F., Pastorek, J., Pastorekova, S., Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with β-catenin (2003) Experimental Cell Research, 290 (2), pp. 332-345. , DOI 10.1016/S0014-4827(03)00351-3
Zavadova, Z., Zavada, J., Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment (2005) Oncol. Rep., 13, pp. 977-982
Zavada, J., Zavadova, Z., Pastorek, J., Biesova, Z., Jezek, J., Velek, J., Human tumour-associated cell adhesion protein MN/CA IX: Identification of M75 epitope and of the region mediating cell adhesion (2000) British Journal of Cancer, 82 (11), pp. 1808-1813
Hulikova, A., Zatovicova, M., Svastova, E., Ditte, P., Brasseur, R., Kettmann, R., Supuran, C.T., Pastorekova, S., Intact intracellular tail is critical for proper functioning of the tumorassociated, hypoxia-regulated carbonic anhydrase IX (2009) FEBS Lett., 583, pp. 3563-3568
Kannan, K.K., Ramanadham, M., Jones, T.A., Structure, refinement, and function of carbonic anhydrase isozymes: Refinement of human carbonic anhydrase I (1984) Annals of the New York Academy of Sciences, 429, pp. 49-60
Eriksson, A.E., Kylsten, P.M., Jones, T.A., Liljas, A., Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: A pentacoordinated binding of the SCN - ion to the zinc at high pH (1988) Proteins: Structure, Function and Genetics, 4 (4), pp. 283-293. , DOI 10.1002/prot.340040407
Eriksson, A.E., Liljas, A., Refined structure of bovine carbonic anhydrase III at 2.0 A resolution (1993) Proteins: Structure, Function and Genetics, 16 (1), pp. 29-42
Boriack-Sjodin, P.A., Heck, R.W., Laipis, P.J., Silverman, D.N., Christianson, D.W., Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: Implications for catalytic proton transfer and inhibitor design (1995) Proc. Natl. Acad. Sci. U.S.A., 92, pp. 10949-10953
Stams, T., Nair, S.K., Okuyama, T., Waheed, A., Sly, W.S., Christianson, D.W., Crystal structure of the secretory form of membrane-Associated human carbonic anhydrase IV at 2.8-A resolution (1996) Proc. Natl. Acad. Sci. U.S.A., 93, pp. 13589-13594
Whittington, D.A., Waheed, A., Ulmasov, B., Shah, G.N., Grubb, J.H., Sly, W.S., Christianson, D.W., Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (17), pp. 9545-9550. , DOI 10.1073/pnas.161301298
Duda, D.M., Tu, C., Fisher, S.Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P.J., McKenna, R., Human carbonic anhydrase III: Structural and kinetic study of catalysis and proton transfer (2005) Biochemistry, 44 (30), pp. 10046-10053. , DOI 10.1021/bi050610h
Di Fiore, A., Monti, S.M., Hilvo, M., Parkkila, S., Romano, V., Scaloni, A., Pedone, C., De Simone, G., Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide (2009) Proteins, 74, pp. 164-175
Di Fiore, A., Truppo, E., Supuran, C.T., Alterio, V., Dathan, N., Bootorabi, F., Parkkila, S., De Simone, G., Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide (2010) Bioorg. Med. Chem. Lett., 20, pp. 5023-5026
Alterio, V., Di Fiore, A., D'Ambrosio, K., Supuran, C.T., De Simone, G., (2009) Drug Design of Zinc-Enzyme Inhibitors: Functional Structural and Disease Applications, pp. 73-138. , Supuran C. T., Winum, J.-Y., Eds.
Domsic, J.F., Avvaru, B.S., Kim, C.U., Gruner, S.M., Agbandje-McKenna, M., Silverman, D.N., McKenna, R., Entrapment of carbon dioxide in the active site of carbonic anhydrase II (2008) J. Biol. Chem., 283, pp. 30766-30771
Merz Jr., K.M., Carbon dioxide binding to human carbonic anhydrase II (1991) J. Am. Chem. Soc., 113, pp. 406-411
Tu, C., Silverman, D.N., Forsman, C., Johnsson, B.-H., Lindskog, S., Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant (1989) Biochemistry, 28 (19), pp. 7913-7918
Roy, A., Taraphder, S., Identification of proton-transfer pathways in human carbonic anhydrase II (2007) Journal of Physical Chemistry B, 111 (35), pp. 10563-10576. , DOI 10.1021/jp073499t
Fisher, S.Z., Maupin, C.M., Budayova-Spano, M., Govindasamy, L., Tu, C., Agbandje-McKenna, M., Silverman, D.N., McKenna, R., Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: Insights into the proton transfer mechanism (2007) Biochemistry, 46 (11), pp. 2930-2937. , DOI 10.1021/bi062066y
Chrastina, A., Zavada, J., Parkkila, S., Kaluz, S., Kaluzova, M., Rajcani, J., Pastorek, J., Pastorekova, S., Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma (2003) International Journal of Cancer, 105 (6), pp. 873-881. , DOI 10.1002/ijc.11142
Klatte, T., Seligson, D.B., Rao, J.Y., Yu, H., De Martino, M., Kawaoka, K., Wong, S.G., Pantuck, A.J., Carbonic anhydrase IX in bladder cancer: A diagnostic, prognostic, and therapeutic molecular marker (2009) Cancer, 115, pp. 1448-1458
Jensen, H.K., Nordsmark, M., Donskov, F., Marcussen, N., Von Der Maase, H., Immunohistochemical expression of carbonic anhydrase IX assessed over time and during treatment in renal cell carcinoma (2008) BJU Int., 101, pp. 41-44
Oosterwijk, E., Ruiter, D.J., Hoedemaeker Ph., J., Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney (1986) International Journal of Cancer, 38 (4), pp. 489-494
Grabmaier, K., Vissers, J.L.M., De Weijert, M.C.A., Oosterwijk-Wakka, J.C., Van Bokhoven, A., Brakenhoff, R.H., Noessner, E., Oosterwijk, E., Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250 (2000) International Journal of Cancer, 85 (6), pp. 865-870. , DOI 10.1002/(SICI)1097-0215(20000315)85:6<865::AID-IJC21>
3.0.CO
Oosterwijk, E., Bander, N.H., Divgi, C.R., Welt, S., Wakka, J.C., Finn, R.D., Carswell, E.A., Old, L.J., Antibody localization in human renal cell carcinoma: A phase I study of monoclonal antibody G250 (1993) Journal of Clinical Oncology, 11 (4), pp. 738-750
Divgi, C.R., Bander, N.H., Scott, A.M., O'Donoghue, J.A., Sgouros, G., Welt, S., Finn, R.D., Old, L.J., Phase I/II radioimmunotherapy trial with iodine-131-labeled monoclonal antibody G250 in metastatic renal cell carcinoma (1998) Clinical Cancer Research, 4 (11), pp. 2729-2739
Steffens, M.G., Boerman, O.C., Oosterwijk-Wakka, J.C., Oosterhof, G.O.N., Witjes, J.A., Koenders, E.B., Oyen, W.J.G., Oosterwijk, E., Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250 (1997) Journal of Clinical Oncology, 15 (4), pp. 1529-1537
Brouwers, A.H., Mulders, P.F.A., De Mulder, P.H.M., Van Den Broek, W.J.M., Buijs, W.C.A.M., Mala, C., Joosten, F.B.M., Oyen, W.J.G., Lack of efficacy of two consecutive treatments of radioimmunotherapy with 131I-cG250 in patients with metastasized clear cell renal cell carcinoma (2005) Journal of Clinical Oncology, 23 (27), pp. 6540-6548. , DOI 10.1200/JCO.2005.07.732
Pryma, D.A., O'Donoghue, J.A., Humm, J.L., Jungbluth, A.A., Old, L.J., Larson, S.M., Divgi, C.R., Correlation of in vivo and in vitro measures of carbonic anhydrase IX antigen expression in renal masses using antibody 124I-cG250 (2011) J. Nucl. Med., 52, pp. 535-540
Brouwers, A.H., Van Eerd, J.E.M., Frielink, C., Oosterwijk, E., Oyen, W.J.G., Corstens, F.H.M., Boerman, O.C., Optimization of radioimmunotherapy of renal cell carcinoma: Labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re (2004) Journal of Nuclear Medicine, 45 (2), pp. 327-337. , http://jnm.snmjournals.org/cgi/reprint/45/2/327
Siebels, M., Rohrmann, K., Oberneder, R., Stahler, M., Haseke, N., Beck, J., Hofmann, R., Stief, C., A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-Alpha-2a in metastatic renal cell carcinoma patients (2011) World J. Urol., 29, pp. 121-126
Reichert, J.M., Antibody-based therapeutics to watch in 2011 (2011) MAbs, 3, pp. 76-99
Hoeben, B.A., Kaanders, J.H., Franssen, G.M., Troost, E.G., Rijken, P.F., Oosterwijk, E., Van Dongen, G.A., Bussink, J., PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors (2010) J. Nucl. Med., 51, pp. 1076-1083
Chopra, A., 111In]-Labeled divalent Fab fragment of chimeric monoclonal antibody cG250 directed against carbonic anhydrase IX (2004) Molecular Imaging and Contrast Agent Database (MICAD) [Internet], p. 2010. , Bethesda (MD): National Center for Biotechnology Information (US)
Zat'ovicova, M., Tarabkova, K., Svastova, E., Gibadulinova, A., Mucha, V., Jakubickova, L., Biesova, Z., Pastorekova, S., Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX (2003) Journal of Immunological Methods, 282 (1-2), pp. 117-134. , DOI 10.1016/j.jim.2003.08.011
Ahlskog, J.K., Schliemann, C., Marlind, J., Qureshi, U., Ammar, A., Pedley, R.B., Neri, D., Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours (2009) Br. J. Cancer, 101, pp. 645-657
Xu, C., Lo, A., Yammanuru, A., Tallarico, A.S., Brady, K., Murakami, A., Barteneva, N., Marasco, W.A., Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology (2010) PLoS One, 5, pp. e9625
Murri-Plesko, M.T., Hulikova, A., Oosterwijk, E., Scott, A.M., Zortea, A., Harris, A.L., Ritter, G., Renner, C., Antibody inhibiting enzymatic activity of tumour-Associated carbonic anhydrase isoform IX (2011) Eur. J. Pharmacol., 657, pp. 173-183
Scozzafava, A., Mastrolorenzo, A., Supuran, C.T., Modulation of carbonic anhydrase activity and its applications in therapy (2004) Expert Opinion on Therapeutic Patents, 14 (5), pp. 667-702. , DOI 10.1517/13543776.14.5.667
Pastorekova, S., Casini, A., Scozzafava, A., Vullo, D., Pastorek, J., Supuran, C.T., Carbonic anhydrase inhibitors: The first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX (2004) Bioorganic and Medicinal Chemistry Letters, 14 (4), pp. 869-873. , DOI 10.1016/j.bmcl.2003.12.029
Thiry, A., Dogne, J.-M., Masereel, B., Supuran, C.T., Targeting tumor-associated carbonic anhydrase IX in cancer therapy (2006) Trends in Pharmacological Sciences, 27 (11), pp. 566-573. , DOI 10.1016/j.tips.2006.09.002, PII S0165614706002203
Ahlskog, J.K.J., Dumelin, C.E., Trüssel, S., Marlind, J., Neri, D., In vivo targeting of tumor-Associated carbonic anhydrases using acetazolamide derivatives (2009) Bioorg. Med. Chem. Lett., 19, pp. 4851-4856
Dubois, L., Lieuwes, N.G., Maresca, A., Thiry, A., Supuran, C.T., Scozzafava, A., Wouters, B.G., Lambin, P., Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model (2009) Radiother. Oncol., 92, pp. 423-428
Pacchiano, F., Carta, F., McDonald, P.C., Lou, Y., Vullo, D., Scozzafava, A., Dedhar, S., Supuran, C.T., Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis (2011) J. Med. Chem., 54, pp. 1896-902
Maresca, A., Temperini, C., Vu, H., Pham, N.B., Poulsen, S.A., Scozzafava, A., Quinn, R.J., Supuran, C.T., Non-zinc mediated inhibition of carbonic anhydrases: Coumarins are a new class of suicide inhibitors (2009) J. Am. Chem. Soc., 131, pp. 3057-3062
Maresca, A., Supuran, C.T., Coumarins incorporating hydroxy-And chloromoieties selectively inhibit the transmembrane, tumor-Associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II (2010) Bioorg Med. Chem. Lett., 20, pp. 4511-4514
Lou, Y., McDonald, P.C., Oloumi, A., Chia, S.K., Ostlund, C., Ahmadi, A., Kyle, A., Dedhar, S., Targeting tumor hypoxia: Suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors (2011) Cancer Res., 71, pp. 3364-3376
Maresca, A., Scozzafava, A., Supuran, C.T., 7,8-Disubstituted-but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumorassociated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range (2010) Bioorg. Med. Chem Lett., 20, pp. 7255-7258
Parkkila, S., Innocenti, A., Kallio, H., Hilvo, M., Scozzafava, A., Supuran, C.T., The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian β-carbonic anhydrase isoforms (2009) Bioorg. Med. Chem. Lett., 19, pp. 4102-4106
Li, S., Kussie, P., Ferguson, K.M., Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8 (2008) Structure, 16 (2), pp. 216-227. , DOI 10.1016/j.str.2007.11.009, PII S0969212608000051
Freeman, M.M., Seaman, M.S., Rits-Volloch, S., Hong, X., Kao, C.Y., Ho, D.D., Chen, B., Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody (2010) Structure, 18, pp. 1632-1641
Supuran, C. T., Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators (2008) Nature Reviews Drug Discovery, 7 (2), pp. 168-181. , DOI 10. 1038/nrd2467, PII NRD246
Krishnamurthy, V. M., Kaufman, G. K., Urbach, A. R., Gitlin, I., Gudiksen, K. L., Weibel, D. B., Whitesides, G. M., Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding (2008) Chemical Reviews, 108 (3), pp. 946-1051. , DOI 10. 1021/cr050262p
Supuran, C. T., Winum, J. -Y., (2009) Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications, (PART II). , Wiley: Hoboken, New Jersey
Supuran, C. T., Scozzafava, A., Conway, J., (2004) Carbonic Anhydrase: Its Inhibitors and Activators, , CRC Press: Boca Raton, FL
Maren, T. H., Carbonic anhydrase: Chemistry, physiology, and inhibition (1967) Physiol. Rev., 47, pp. 595-781
Supuran, C. T., Di Fiore, A., Alterio, V., Monti, S. M., De Simone, G., Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII (2010) Curr. Pharm. Des., 16, pp. 3246-3254
Guler, O. O., De Simone, G., Supuran, C. T., Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (2010) Curr. Med. Chem., 17, pp. 1516-1526
Pastorekov, S., Z vadov, Z., Kost l, M., Babus kov, O., Z vada, J., A novel quasi-viral agent, MaTu, is a two-component system (1992) Virology, 187, pp. 620-626
Stillebroer, A. B., Mulders, P. F., Boerman, O. C., Oyen, W. J., Oosterwijk, E., Carbonic anhydrase IX in renal cell carcinoma: Implications for prognosis, diagnosis, and therapy (2010) Eur. Urol., 58, pp. 75-83
Pastorekov, S., Pastorek, J., (2004) Carbonic Anhydrase: Its Inhibitors and Activators, pp. 255-281. , Supuran, C. T.
Parent, A. S., Mungenast, A. E., Lomniczi, A., Sandau, U. S., Peles, E., Bosch, M. A., R nnekleiv, O. K., Ojeda, S. R., A contactin-receptor-like protein tyrosine phosphatase beta complex mediates adhesive communication between astroglial cells and gonadotrophin-releasing hormone neurones (2007) J. Neuroendocrinol., 19, pp. 847-859
Funderburgh, J. L., Keratan sulfate: Structure, biosynthesis, and function (2000) Glycobiology, 10, pp. 951-958
Maxwell, P. H., Wlesener, M. S., Chang, G. -W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Ratcliffe, P. J., The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis (1999) Nature, 399 (6733), pp. 271-275. , DOI 10. 1038/20459
Huang, L. E., Bunn, H. F., Hypoxia-inducible factor and its biomedical relevance (2003) Journal of Biological Chemistry, 278 (22), pp. 19575-19578. , DOI 10. 1074/jbc. R200030200
Coleman, M. L., Ratcliffe, P. J., Oxygen sensing and hypoxia-induced responses (2007) Essays Biochem., 43, pp. 1-15
Wykoff, C. C., Beasley, N. J. P., Watson, P. H., Turner, K. J., Pastorek, J., Sibtain, A., Wilson, G. D., Ratcliffe, P. J., Hypoxia-inducible expression of tumor-associated carbonic anhydrases (2000) Cancer Research, 60 (24), pp. 7075-7083
Lee, A. H., Tannock, I. F., Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells (1998) Cancer Research, 58 (9), pp. 1901-1908
McLean, L. A., Roscoe, J., Jorgensen, N. K., Gorin, F. A., Cala, P. M., Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes (2000) American Journal of Physiology - Cell Physiology, 278 (4-47), pp. C676-C688
Boron, W. F., Regulation of intracellular pH (2004) Adv. Physiol. Educ., 28, pp. 160-179
Morgan, P. E., Pastorekova, S., Stuart-Tilley, A. K., Alper, S. L., Casey, J. R., Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters (2007) American Journal of Physiology - Cell Physiology, 293 (2), pp. C738-C748. , http: //ajpcell. physiology. org/cgi/reprint/293/2/C738, DOI 10. 1152/ajpcell. 00157. 2007
Casey, J. R., Why bicarbonate? (2006) Biochemistry and Cell Biology, 84 (6), pp. 930-939. , DOI 10. 1139/O06-184
Kannan, K. K., Ramanadham, M., Jones, T. A., Structure, refinement, and function of carbonic anhydrase isozymes: Refinement of human carbonic anhydrase I (1984) Annals of the New York Academy of Sciences, 429, pp. 49-60
Eriksson, A. E., Kylsten, P. M., Jones, T. A., Liljas, A., Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: A pentacoordinated binding of the SCN - ion to the zinc at high pH (1988) Proteins: Structure, Function and Genetics, 4 (4), pp. 283-293. , DOI 10. 1002/prot. 340040407
Eriksson, A. E., Liljas, A., Refined structure of bovine carbonic anhydrase III at 2. 0 A resolution (1993) Proteins: Structure, Function and Genetics, 16 (1), pp. 29-42
Boriack-Sjodin, P. A., Heck, R. W., Laipis, P. J., Silverman, D. N., Christianson, D. W., Structure determination of murine mitochondrial carbonic anhydrase V at 2. 45-A resolution: Implications for catalytic proton transfer and inhibitor design (1995) Proc. Natl. Acad. Sci. U. S. A., 92, pp. 10949-10953
Whittington, D. A., Waheed, A., Ulmasov, B., Shah, G. N., Grubb, J. H., Sly, W. S., Christianson, D. W., Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (17), pp. 9545-9550. , DOI 10. 1073/pnas. 161301298
Duda, D. M., Tu, C., Fisher, S. Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P. J., McKenna, R., Human carbonic anhydrase III: Structural and kinetic study of catalysis and proton transfer (2005) Biochemistry, 44 (30), pp. 10046-10053. , DOI 10. 1021/bi050610h
Domsic, J. F., Avvaru, B. S., Kim, C. U., Gruner, S. M., Agbandje-McKenna, M., Silverman, D. N., McKenna, R., Entrapment of carbon dioxide in the active site of carbonic anhydrase II (2008) J. Biol. Chem., 283, pp. 30766-30771
Merz Jr., K. M., Carbon dioxide binding to human carbonic anhydrase II (1991) J. Am. Chem. Soc., 113, pp. 406-411
Fisher, S. Z., Maupin, C. M., Budayova-Spano, M., Govindasamy, L., Tu, C., Agbandje-McKenna, M., Silverman, D. N., McKenna, R., Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: Insights into the proton transfer mechanism (2007) Biochemistry, 46 (11), pp. 2930-2937. , DOI 10. 1021/bi062066y
Jensen, H. K., Nordsmark, M., Donskov, F., Marcussen, N., Von Der Maase, H., Immunohistochemical expression of carbonic anhydrase IX assessed over time and during treatment in renal cell carcinoma (2008) BJU Int., 101, pp. 41-44
Divgi, C. R., Bander, N. H., Scott, A. M., O'Donoghue, J. A., Sgouros, G., Welt, S., Finn, R. D., Old, L. J., Phase I/II radioimmunotherapy trial with iodine-131-labeled monoclonal antibody G250 in metastatic renal cell carcinoma (1998) Clinical Cancer Research, 4 (11), pp. 2729-2739
Steffens, M. G., Boerman, O. C., Oosterwijk-Wakka, J. C., Oosterhof, G. O. N., Witjes, J. A., Koenders, E. B., Oyen, W. J. G., Oosterwijk, E., Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250 (1997) Journal of Clinical Oncology, 15 (4), pp. 1529-1537
Brouwers, A. H., Mulders, P. F. A., De Mulder, P. H. M., Van Den Broek, W. J. M., Buijs, W. C. A. M., Mala, C., Joosten, F. B. M., Oyen, W. J. G., Lack of efficacy of two consecutive treatments of radioimmunotherapy with 131I-cG250 in patients with metastasized clear cell renal cell carcinoma (2005) Journal of Clinical Oncology, 23 (27), pp. 6540-6548. , DOI 10. 1200/JCO. 2005. 07. 732
Pryma, D. A., O'Donoghue, J. A., Humm, J. L., Jungbluth, A. A., Old, L. J., Larson, S. M., Divgi, C. R., Correlation of in vivo and in vitro measures of carbonic anhydrase IX antigen expression in renal masses using antibody 124I-cG250 (2011) J. Nucl. Med., 52, pp. 535-540
Brouwers, A. H., Van Eerd, J. E. M., Frielink, C., Oosterwijk, E., Oyen, W. J. G., Corstens, F. H. M., Boerman, O. C., Optimization of radioimmunotherapy of renal cell carcinoma: Labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re (2004) Journal of Nuclear Medicine, 45 (2), pp. 327-337. , http: //jnm. snmjournals. org/cgi/reprint/45/2/327
Reichert, J. M., Antibody-based therapeutics to watch in 2011 (2011) MAbs, 3, pp. 76-99
Hoeben, B. A., Kaanders, J. H., Franssen, G. M., Troost, E. G., Rijken, P. F., Oosterwijk, E., Van Dongen, G. A., Bussink, J., PET of hypoxia with 89Zr-labeled cG250-F (ab') 2 in head and neck tumors (2010) J. Nucl. Med., 51, pp. 1076-1083
Chopra, A., 111In] -Labeled divalent Fab fragment of chimeric monoclonal antibody cG250 directed against carbonic anhydrase IX (2004) Molecular Imaging and Contrast Agent Database (MICAD) [Internet], p. 2010. , Bethesda (MD): National Center for Biotechnology Information (US)
Ahlskog, J. K., Schliemann, C., Marlind, J., Qureshi, U., Ammar, A., Pedley, R. B., Neri, D., Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours (2009) Br. J. Cancer, 101, pp. 645-657
Murri-Plesko, M. T., Hulikova, A., Oosterwijk, E., Scott, A. M., Zortea, A., Harris, A. L., Ritter, G., Renner, C., Antibody inhibiting enzymatic activity of tumour-Associated carbonic anhydrase isoform IX (2011) Eur. J. Pharmacol., 657, pp. 173-183
Ahlskog, J. K. J., Dumelin, C. E., Tr ssel, S., Marlind, J., Neri, D., In vivo targeting of tumor-Associated carbonic anhydrases using acetazolamide derivatives (2009) Bioorg. Med. Chem. Lett., 19, pp. 4851-4856
Freeman, M. M., Seaman, M. S., Rits-Volloch, S., Hong, X., Kao, C. Y., Ho, D. D., Chen, B., Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody (2010) Structure, 18, pp. 1632-1641
Carbonic anhydrase IX as a target for designing novel anticancer drugs
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(307 views) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 ViewExport to BibTeXExport to EndNote