Keywords: Lactuloselysine, Lc-Ms, Maillard Reaction, Milklike Model Systems, Drug Derivative, Epsilon-N-1-(1-Deoxylactulosyl)lysine, Lactose, Milk Protein, Selenium Derivative, Unclassified Drug, Whey Protein, Animal, Article, Chemical Reaction, Chemistry, Food Processing, Food Quality, Glycation, Liquid Chromatography, Mass Spectrometry, Nutritional Value, Synthesis, Epsilon-N-1-(1-Deoxylactulosyl) Lysine,
Affiliations: Dipto. di Scienza degli Alimenti, Univ. Studi di Napoli Federico II, Parco Gussone, 80055 Portici, Napoli, Italy
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Berg, H. E., Van Boekel, M. A. J. S., Degratation of lactose during heating of milk. 1 reaction pathways (1994) Netherland Milk Dairy J., 48, pp. 157-175
Carpino, L. A., Han, G. Y., The 9-fluorenylmethoxycarbonyl amino-protecting group (1972) J. Org. Chem., 37, pp. 3404-3409
Erbersdobler, H. F., Twenty years of furosine - Better knowledge about the biological significance of Maillard reaction in food and nutrition (1985) Proceedings of the 3rd International Symposium on the Maillard Reaction: "Amino-carbonyl Reaction in Food and Biological Systems", , Fuji Institute, Japan
Finot, P. A., Metabolism and physiological effects of maillard reaction products (1990) The Maillard Reaction in Food Processing, Human Nutrition and Physiology, , Finot, P. A., Aeschbacher, H., Hurrel, R. F., Liardon, R., Eds.
Finot, P. A., Deutsch, R., Bujard, E., The exent of the maillard reaction during the processing of milk (1981) Prog. Fd. Nutr. Sci., 5, pp. 345-355
Finot, P. A., Mauron, J., Le blocage de la lysine par la r action de Maillard. I. Synth se de N- (d soxy-1-D-fructosil-1-) et N- (d soxy-1-D-lactulosil-1-) -L-lysine (1969) Helv. Chim. Acta, 52, pp. 1488-1495
Monti, S. M., Bailey, R. G., Ames, J. M., The influence of pH on the non-volatile reaction products of aqueous maillard model systems by HPLC with diode array detection (1998) Food Chem., 62, pp. 369-375
Morales, F. J., Jemenez Perez, S., Study of HMF formed from acid degradation of the A. P. In milk resembling system (1998) J. Agric. Food. Chem., 46, pp. 3885-3890
Schreuder, H. A., Welling, G. W., Determination of -galactosidase activity in the intestinal tract of mice by ion-exchange high-performance liquid chromatography using -N-1- (1-deoxylactulosil) -L-lysine as substrate (1983) J. Chromatoer., 278, pp. 275-282
Convenient synthesis of lactuloselysine and its use for LC-MS analysis in milk-like model systems
The synthesis of the Amadori product lactuloselysine [N(ε)(1-deoxy-D- lactulosyl-1)-L-lysine] was obtained starting from FMOC-lysine-OH (N(α)-9- fluorenylmethoxy-carbonyl-N(ε)H2-L-lysine-OH) and lactose. Compound identity was confirmed by MALDI-ToF, electrospray, and NMR analysis. A selective LC-MS procedure which allowed the detection of lactuloselysine up to 10 ng mL-1 was set up and used to follow the formation of the compound in a lactose-lysine model system; quantification of this molecule after complete enzymatic hydrolysis of whey-proteins from milk samples was also performed.
Convenient synthesis of lactuloselysine and its use for LC-MS analysis in milk-like model systems
No results.
Convenient synthesis of lactuloselysine and its use for LC-MS analysis in milk-like model systems