Extraction of azadirachtin a from neem seed kernels by supercritical fluid and its evaluation by HPLC and LC/MS (512 views)
J Agric Food Chem (ISSN: 0021-8561), 1999 Dec; 47(12): 5252-5256.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.453, 5-year impact factor: 3.172
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0033381442&partnerID=40&md5=0dd487820ee7057507671506e5f1fa4d
Keywords: Azadirachtin A, Hplc, Lc Ms, Neem Seed Kernels, Supercritical Fluid Extraction, Carbon Dioxide, Insecticide, Triterpene, Animal, Article, Calculation, Chemical Structure, Chemistry, Controlled Study, High Performance Liquid Chromatography, Isolation And Purification, Mass Fragmentography, Mass Spectrometry, Nonhuman, Plant Seed, High Pressure Liquid, Gas Chromatography-Mass Spectrometry, Limonins, Trees, Azadirachta Indica,
Affiliations:
Dipto. di Scienza degli Alimenti, Universita Napoli Federico II P., 80055 Portici (Napoli), Italy
Dipartimento di Ingegneria Chimica, Università di Salerno, via Ponte Don Melillo, 84084 Fisciano (Salerno), Italy
References:
Broughton, H.B., Ley, S.V., Slawin, A.M.Z., Williams, D.J., Morgan, E.D., X-ray crystallographic structure determination of detigloyldihydro-azadirachtin and reassignment of the structure of limonoid insect antifeedant azadirachtin (1986) J. Chem. Soc., Chem. Commun., pp. 46-4
Cernia, E., D'Andrea, A., Nocera, R., Palocci, C., Pedrazzi, E., SFE/SFC of secondary metabolites from plant tissue culture of Azadirachta indica (A. Juss) (1997) 4th International Symposium on Supercritical Fluids, , Sendai, Japan, May 11-14
Chary, M.P., Reddy, E.J.S., Reddy, S.M., Screening of indigenous plants for their antifungal principle (1984) Pesticides, 18, pp. 17-18
Chattopadhyay, R.R., Sarkar, S.K., Ganguly, S., Banerjee, R.N., Active effects of Azadirachta indica leaves on some biochemical constituents of blood in rats (1992) Sci. Cult., 58, pp. 39-40
Cook, R.J., Baker, K.F., The nature and practice of biological control of plant pathogens (1983) The American Phytopathological Society, , St. Paul, MN
Djarmati, Z., Jankov, R.M., Schwirtlich, E., Djulinac, B., Djordjevic, A., High antioxidant activity of extracts obtained from sage by supercritical CO2 extraction (1991) J. Am. Oil Chem. Soc., 68, pp. 731-734
Greibrokk, T., Recent developments in the use of supercritical fluids in coupled systems (1992) J. Chromatogr., 626, pp. 33-40
Jacobson, M., The Neem tree: Natural resistance par excellence (1986) ACS Symp. Ser., 296, pp. 220-232
Jones, P.S., Ley, S.V., Morgan, E.D., Santafianos, D., (1989) 1988 Focus on Phytochemical Pesticides. Vol. I. The Neem Tree, 1, pp. 19-45. , CRC Press: Boca Raton, FL
Klassen, C.D., Amdur, M.O., (1986) Casarett and Doull's Toxicology: The Basic Science of Poisons, , MacMillan Publishing: New York
Kraus, W., Bokel, M., Klenk, A., Pàhnl, H., The structure of azadirachtin and 22,23-dihydro-23-β-methoxyazadirachtin (1985) Tetrahedron Lett., 26, pp. 6435-6438
Marquis, J.K., (1986) Contemporary Issues in Pesticide Toxicology and Pharmacology, , Karger: Basel, Switzerland
Muehlnikel, T., Extraction with carbon dioxide. Manufacture of dearomatized rosemary antioxidant (1992) Food Market. Technol., 6, pp. 37-38
Rembold, H., Forster, H., Czoppelt, Ch., Rao, J.P., Sieber, K.P., The azadirachtins, a group of insect growth regulators from the Neem tree (1983) Proceedings of the 2nd International Neem Conference, pp. 153-162. , Natural Pesticides from the Neem Tree and Other Tropical Plants
Rauischholzhausen, GTZ: Eschborn, Germany
Nairobi, GTZ: Eschborn, Germany
Reverchon, E., Della Porta, G., Gorgoglione, D., Supercritical fluid extraction of essential oils on a pilot plant (1993) Second Congresso Italiano sui Fluidi Supercritici e le Loro Applicazioni, , Ravello, Italy, July 20-22
Reverchon, E., Sesti Osseo, L., Gorgoglione, D., Supercritical CO2 extraction of basil oil characterization of products and process modeling (1994) J. Supercrit. Fluid, 7, pp. 185-190
Saxena, R.C., Jilani, G., Abdul Karim, A., Effects of Neem on stored grain insects (1989) 1988 Focus on Phytochemical Pesticides. Vol. I. The Neem Tree, 1, pp. 97-111. , CRC Press: Boca Raton, FL
Schmutterer, H., Properties and potential of natural pesticides from the Neem tree, Azadirachta indica (1990) Annu. Rev. Entomol., 35, pp. 271-297
Schroeder, D., Nakanishi, K., A simplified isolation procedure for azadirachtin (1987) J. Nat. Prod., 50, pp. 241-244
Sharpe, F.R., Crabb, D., Pilot plant extraction of hops with liquid carbon dioxide and the use of these extracts in pilot and production scale brewing (1980) J. Inst. Brew., 86, p. 60
Spanos, G.A., Chen, H., Schwartz, J., Supercritical CO2 extraction of β-carotene from sweet potatoes (1993) J. Food Sci., 58, pp. 817-820
Broughton, H. B., Ley, S. V., Slawin, A. M. Z., Williams, D. J., Morgan, E. D., X-ray crystallographic structure determination of detigloyldihydro-azadirachtin and reassignment of the structure of limonoid insect antifeedant azadirachtin (1986) J. Chem. Soc., Chem. Commun., pp. 46-4
Chary, M. P., Reddy, E. J. S., Reddy, S. M., Screening of indigenous plants for their antifungal principle (1984) Pesticides, 18, pp. 17-18
Chattopadhyay, R. R., Sarkar, S. K., Ganguly, S., Banerjee, R. N., Active effects of Azadirachta indica leaves on some biochemical constituents of blood in rats (1992) Sci. Cult., 58, pp. 39-40
Cook, R. J., Baker, K. F., The nature and practice of biological control of plant pathogens (1983) The American Phytopathological Society, , St. Paul, MN
Jones, P. S., Ley, S. V., Morgan, E. D., Santafianos, D., (1989) 1988 Focus on Phytochemical Pesticides. Vol. I. The Neem Tree, 1, pp. 19-45. , CRC Press: Boca Raton, FL
Klassen, C. D., Amdur, M. O., (1986) Casarett and Doull's Toxicology: The Basic Science of Poisons, , MacMillan Publishing: New York
Marquis, J. K., (1986) Contemporary Issues in Pesticide Toxicology and Pharmacology, , Karger: Basel, Switzerland
Saxena, R. C., Jilani, G., Abdul Karim, A., Effects of Neem on stored grain insects (1989) 1988 Focus on Phytochemical Pesticides. Vol. I. The Neem Tree, 1, pp. 97-111. , CRC Press: Boca Raton, FL
Sharpe, F. R., Crabb, D., Pilot plant extraction of hops with liquid carbon dioxide and the use of these extracts in pilot and production scale brewing (1980) J. Inst. Brew., 86, p. 60
Spanos, G. A., Chen, H., Schwartz, J., Supercritical CO2 extraction of -carotene from sweet potatoes (1993) J. Food Sci., 58, pp. 817-820
J Agric Food Chem (ISSN: 0021-8561), 1999 Dec; 47(12): 5252-5256.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.453, 5-year impact factor: 3.172
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0033381442&partnerID=40&md5=0dd487820ee7057507671506e5f1fa4d
Keywords: Azadirachtin A, Hplc, Lc Ms, Neem Seed Kernels, Supercritical Fluid Extraction, Carbon Dioxide, Insecticide, Triterpene, Animal, Article, Calculation, Chemical Structure, Chemistry, Controlled Study, High Performance Liquid Chromatography, Isolation And Purification, Mass Fragmentography, Mass Spectrometry, Nonhuman, Plant Seed, High Pressure Liquid, Gas Chromatography-Mass Spectrometry, Limonins, Trees, Azadirachta Indica,
Affiliations:
Dipto. di Scienza degli Alimenti, Universita Napoli Federico II P., 80055 Portici (Napoli), Italy
Dipartimento di Ingegneria Chimica, Università di Salerno, via Ponte Don Melillo, 84084 Fisciano (Salerno), Italy
References:
Broughton, H.B., Ley, S.V., Slawin, A.M.Z., Williams, D.J., Morgan, E.D., X-ray crystallographic structure determination of detigloyldihydro-azadirachtin and reassignment of the structure of limonoid insect antifeedant azadirachtin (1986) J. Chem. Soc., Chem. Commun., pp. 46-4
Cernia, E., D'Andrea, A., Nocera, R., Palocci, C., Pedrazzi, E., SFE/SFC of secondary metabolites from plant tissue culture of Azadirachta indica (A. Juss) (1997) 4th International Symposium on Supercritical Fluids, , Sendai, Japan, May 11-14
Chary, M.P., Reddy, E.J.S., Reddy, S.M., Screening of indigenous plants for their antifungal principle (1984) Pesticides, 18, pp. 17-18
Chattopadhyay, R.R., Sarkar, S.K., Ganguly, S., Banerjee, R.N., Active effects of Azadirachta indica leaves on some biochemical constituents of blood in rats (1992) Sci. Cult., 58, pp. 39-40
Cook, R.J., Baker, K.F., The nature and practice of biological control of plant pathogens (1983) The American Phytopathological Society, , St. Paul, MN
Djarmati, Z., Jankov, R.M., Schwirtlich, E., Djulinac, B., Djordjevic, A., High antioxidant activity of extracts obtained from sage by supercritical CO2 extraction (1991) J. Am. Oil Chem. Soc., 68, pp. 731-734
Greibrokk, T., Recent developments in the use of supercritical fluids in coupled systems (1992) J. Chromatogr., 626, pp. 33-40
Jacobson, M., The Neem tree: Natural resistance par excellence (1986) ACS Symp. Ser., 296, pp. 220-232
Jones, P.S., Ley, S.V., Morgan, E.D., Santafianos, D., (1989) 1988 Focus on Phytochemical Pesticides. Vol. I. The Neem Tree, 1, pp. 19-45. , CRC Press: Boca Raton, FL
Klassen, C.D., Amdur, M.O., (1986) Casarett and Doull's Toxicology: The Basic Science of Poisons, , MacMillan Publishing: New York
Kraus, W., Bokel, M., Klenk, A., Pàhnl, H., The structure of azadirachtin and 22,23-dihydro-23-β-methoxyazadirachtin (1985) Tetrahedron Lett., 26, pp. 6435-6438
Marquis, J.K., (1986) Contemporary Issues in Pesticide Toxicology and Pharmacology, , Karger: Basel, Switzerland
Muehlnikel, T., Extraction with carbon dioxide. Manufacture of dearomatized rosemary antioxidant (1992) Food Market. Technol., 6, pp. 37-38
Rembold, H., Forster, H., Czoppelt, Ch., Rao, J.P., Sieber, K.P., The azadirachtins, a group of insect growth regulators from the Neem tree (1983) Proceedings of the 2nd International Neem Conference, pp. 153-162. , Natural Pesticides from the Neem Tree and Other Tropical Plants
Rauischholzhausen, GTZ: Eschborn, Germany
Nairobi, GTZ: Eschborn, Germany
Reverchon, E., Della Porta, G., Gorgoglione, D., Supercritical fluid extraction of essential oils on a pilot plant (1993) Second Congresso Italiano sui Fluidi Supercritici e le Loro Applicazioni, , Ravello, Italy, July 20-22
Reverchon, E., Sesti Osseo, L., Gorgoglione, D., Supercritical CO2 extraction of basil oil characterization of products and process modeling (1994) J. Supercrit. Fluid, 7, pp. 185-190
Saxena, R.C., Jilani, G., Abdul Karim, A., Effects of Neem on stored grain insects (1989) 1988 Focus on Phytochemical Pesticides. Vol. I. The Neem Tree, 1, pp. 97-111. , CRC Press: Boca Raton, FL
Schmutterer, H., Properties and potential of natural pesticides from the Neem tree, Azadirachta indica (1990) Annu. Rev. Entomol., 35, pp. 271-297
Schroeder, D., Nakanishi, K., A simplified isolation procedure for azadirachtin (1987) J. Nat. Prod., 50, pp. 241-244
Sharpe, F.R., Crabb, D., Pilot plant extraction of hops with liquid carbon dioxide and the use of these extracts in pilot and production scale brewing (1980) J. Inst. Brew., 86, p. 60
Spanos, G.A., Chen, H., Schwartz, J., Supercritical CO2 extraction of β-carotene from sweet potatoes (1993) J. Food Sci., 58, pp. 817-820
Broughton, H. B., Ley, S. V., Slawin, A. M. Z., Williams, D. J., Morgan, E. D., X-ray crystallographic structure determination of detigloyldihydro-azadirachtin and reassignment of the structure of limonoid insect antifeedant azadirachtin (1986) J. Chem. Soc., Chem. Commun., pp. 46-4
Chary, M. P., Reddy, E. J. S., Reddy, S. M., Screening of indigenous plants for their antifungal principle (1984) Pesticides, 18, pp. 17-18
Chattopadhyay, R. R., Sarkar, S. K., Ganguly, S., Banerjee, R. N., Active effects of Azadirachta indica leaves on some biochemical constituents of blood in rats (1992) Sci. Cult., 58, pp. 39-40
Cook, R. J., Baker, K. F., The nature and practice of biological control of plant pathogens (1983) The American Phytopathological Society, , St. Paul, MN
Jones, P. S., Ley, S. V., Morgan, E. D., Santafianos, D., (1989) 1988 Focus on Phytochemical Pesticides. Vol. I. The Neem Tree, 1, pp. 19-45. , CRC Press: Boca Raton, FL
Klassen, C. D., Amdur, M. O., (1986) Casarett and Doull's Toxicology: The Basic Science of Poisons, , MacMillan Publishing: New York
Marquis, J. K., (1986) Contemporary Issues in Pesticide Toxicology and Pharmacology, , Karger: Basel, Switzerland
Saxena, R. C., Jilani, G., Abdul Karim, A., Effects of Neem on stored grain insects (1989) 1988 Focus on Phytochemical Pesticides. Vol. I. The Neem Tree, 1, pp. 97-111. , CRC Press: Boca Raton, FL
Sharpe, F. R., Crabb, D., Pilot plant extraction of hops with liquid carbon dioxide and the use of these extracts in pilot and production scale brewing (1980) J. Inst. Brew., 86, p. 60
Spanos, G. A., Chen, H., Schwartz, J., Supercritical CO2 extraction of -carotene from sweet potatoes (1993) J. Food Sci., 58, pp. 817-820
Extraction of azadirachtin a from neem seed kernels by supercritical fluid and its evaluation by HPLC and LC/MS
A new supercritical extraction methodology was applied to extract azadirachtin A (AZA-A) from neem seed kernels. Supercritical and liquid carbon dioxide (CO2) were used as extractive agents in a three-separation- stage supercritical pilot plant. Subcritical conditions were tested too. Comparisons were carried out by calculating the efficiency of the pilot plant with respect to the milligrams per kilogram of seeds (ms/mo) of AZA-A extracted. The most convenient extraction was gained using an ms/mo ratio of 119 rather than 64. For supercritical extraction, a separation of cuticular waxes from oil was set up in the pilot plant. HPLC and electrospray mass spectroscopy were used to monitor the yield of AZA-A extraction.
A new supercritical extraction methodology was applied to extract azadirachtin A (AZA-A) from neem seed kernels. Supercritical and liquid carbon dioxide (CO2) were used as extractive agents in a three-separation- stage supercritical pilot plant. Subcritical conditions were tested too. Comparisons were carried out by calculating the efficiency of the pilot plant with respect to the milligrams per kilogram of seeds (ms/mo) of AZA-A extracted. The most convenient extraction was gained using an ms/mo ratio of 119 rather than 64. For supercritical extraction, a separation of cuticular waxes from oil was set up in the pilot plant. HPLC and electrospray mass spectroscopy were used to monitor the yield of AZA-A extraction.
Extraction of azadirachtin a from neem seed kernels by supercritical fluid and its evaluation by HPLC and LC/MS
| ▼ Carbonic Anhydrase IX as target for the development of new anti-tumour drugs |
Extraction of azadirachtin a from neem seed kernels by supercritical fluid and its evaluation by HPLC and LC/MS
Other filter: ([btitle,keywords] "Azadirachtin A" OR [ ...
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J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2012 Jun; 111: 117-129.
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View Export to BibTeX Export to EndNote
Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (386 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
View Export to BibTeX Export to EndNote
Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G
* Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (573 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Sep 22; 106(38): 16233-16238.
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View Export to BibTeX Export to EndNote
14 Records (14 excluding Abstracts).
Total impact factor: 109.421 (109.421 excluding Abstracts).
Total 5 year impact factor: 109.575 (109.575 excluding Abstracts).
Total impact factor: 109.421 (109.421 excluding Abstracts).
Total 5 year impact factor: 109.575 (109.575 excluding Abstracts).
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