gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (445 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.195, 5-year impact factor: 4.53
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84884186694&partnerID=40&md5=53bf2e1bfe4bfb87866fcbd0a8498862
Keywords: Delivery, Cell Penetrating Peptide, Drug Carrier, Gh625 C Prune, Tat C Prune, Transactivator Protein, Unclassified Drug, Virus Glycoprotein, Article, Carboxy Terminal Sequence, Cell Membrane Permeability, Confocal Microscopy, Controlled Study, Drug Conjugation, Drug Delivery System, Drug Mixture, Herpes Simplex Virus 1, Human, Human Cell, Nonhuman, Surface Charge, Carrier Proteins, Circular Dichroism, Endocytosis, Hela Cells, Intrinsically Disordered Proteins, Neoplasm Proteins, Protein Structure, Tertiary, Recombinant Fusion Proteins, Viral Envelope Proteins,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy
Department of Pharmacy and Interuniversity Research Center on Bioactive Peptides, Federico II University of Naples, Naples, Italy
Molecular Diagnostics and Pharmaceuticals Scarl, Naples, Italy
Special Center for Biotechnology, Federico II University of Naples, Naples, Italy
Center for Advanced Biomaterials for Health Care, Interdisciplinary Research Centre on Biomaterials, Italian Institute of Technology, Naples, Italy
Kedrion S.p.A, Sant'Antimo, Naples, Italy
Department of Experimental Medicine, Federico II University of Naples, Naples, Italy
CEINGE - Advanced Biotechnology Scarl, Naples, Italy
Kedrion S. p. A, Sant'Antimo, Naples, Italy
References:
Carberry, T.P., Tarallo, R., Falanga, A., Dendrimer functionalization with a membrane-interacting domain of herpes simplex virus type 1: Towards intracellular delivery (2012) Chemistry, 18 (43), pp. 13678-1368
Guarnieri, D., Falanga, A., Muscetti, O., Shuttle-mediated nanoparticle delivery to the blood brain barrier (2013) Small, 9 (6), pp. 853-862
Zorko, M., Langel, U., Cell-penetrating peptides: Mechanism and kinetics of cargo delivery (2005) Adv Drug Deliv Rev, 57 (4), pp. 529-545
Deshayes, S., Morris, M.C., Divita, G., Heitz, F., Cell-penetrating peptides: Tools for intracellular delivery of therapeutics (2005) Cell Mol Life Sci, 62 (16), pp. 1839-1849
Chang, M., Chou, J.C., Lee, H.J., Cellular internalization of fluorescent proteins via arginine-rich intracellular delivery peptide in plant cells (2005) Plant Cell Physiol, 46 (3), pp. 482-488
Suzuki, T., Futaki, S., Niwa, M., Tanaka, S., Ueda, K., Sugiura, Y., Possible existence of common internalization mechanisms among arginine-rich peptides (2002) J Biol Chem, 277 (4), pp. 2437-2443
Vives, E., Brodin, P., Lebleu, B., A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus (1997) J Biol Chem, 272 (25), pp. 16010-16017
Schwarze, S.R., Dowdy, S.F., In vivo protein transduction: Intracellular delivery of biologically active proteins, compounds and DNA (2000) Trends Pharmacol Sci, 21 (2), pp. 45-48
Duchardt, F., Fotin-Mleczek, M., Schwarz, H., Fischer, R., Brock, R., A comprehensive model for the cellular uptake of cationic cellpenetrating peptides (2007) Traffic, 8 (7), pp. 848-866
Schwarze, S.R., Ho, A., Vocero-Akbani, A., Dowdy, S.F., In vivo protein transduction: Delivery of a biologically active protein into the mouse (1999) Science, 285 (5433), pp. 1569-1572
Galdiero, S., Vitiello, M., Falanga, A., Cantisani, M., Incoronato, N., Galdiero, M., Intracellular delivery: Exploiting viral membranotropic peptides (2012) Curr Drug Metab, 13 (1), pp. 93-104
Galdiero, S., Falanga, A., Vitiello, G., Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (2010) Biochim Biophys Acta, 1798 (3), pp. 579-591
Galdiero, S., Russo, L., Falanga, A., Structure and orientation of the gH625-644 membrane interacting region of herpes simplex virus type 1 in a membrane mimetic system (2012) Biochemistry, 51 (14), pp. 3121-3128
Tarallo, R., Accardo, A., Falanga, A., Clickable functionalization of liposomes with the gH625 peptide from Herpes simplex virus type I for intracellular drug delivery (2011) Chemistry, 17 (45), pp. 12659-12668
Falanga, A., Tarallo, R., Galdiero, E., Cantisani, M., Galdiero, M., Galdiero, S., Review of a viral peptide nanosystem for intracellular delivery (2013) J Nanophoton, 7 (1), p. 071599
Carotenuto, M., Pedone, E., Diana, D., Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (1351) Sci Rep, 2013, p. 3
Kobayashi, T., Hino, S., Oue, N., Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions (2006) Mol Cell Biol, 26 (3), pp. 898-911
Noguchi, T., Oue, N., Wada, S., h-Prune is an independent prognostic marker for survival in esophageal squamous cell carcinoma (2009) Ann Surg Oncol, 16 (5), pp. 1390-1396
Oue, N., Yoshida, K., Noguchi, T., Sentani, K., Kikuchi, A., Yasui, W., Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer (2007) Cancer Sci, 98 (8), pp. 1198-1205
Massidda, B., Sini, M., Budroni, M., Molecular alterations in keyregulator genes among patients with T4 breast carcinoma (2010) BMC Cancer, 10, p. 458
D'Angelo, A., Garzia, L., Andre, A., Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis (2004) Cancer Cell, 5 (2), pp. 137-149
D'Angelo, A., Zollo, M., Unraveling genes and pathways influenced by H-prune PDE overexpression: A model to study cellular motility (2004) Cell Cycle, 3 (6), pp. 758-761
Marino, N., Zollo, M., Understanding h-prune biology in the fight against cancer (2007) Clin Exp Metastasis, 24 (8), pp. 637-645
Galasso, A., Zollo, M., The Nm23-H1-h-Prune complex in cellular physiology: A 'tip of the iceberg' protein network perspective (2009) Mol Cell Biochem, 329 (1-2), pp. 149-159
Hope, M.J., Bally, M.B., Webb, G., Cullis, P.R., Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential (1985) Biochim Biophys Acta, 812 (1), pp. 55-65
Bolen, E.J., Holloway, P.W., Quenching of tryptophan fluorescence by brominated phospholipid (1990) Biochemistry, 29 (41), pp. 9638-9643
de Kroon, A.I., Soekarjo, M.W., de Gier, J., de Kruijff, B., The role of charge and hydrophobicity in peptide-lipid interaction: A comparative study based on tryptophan fluorescence measurements combined with the use of aqueous and hydrophobic quenchers (1990) Biochemistry, 29 (36), pp. 8229-8240
Bourhis, J.M., Receveur-Brechot, V., Oglesbee, M., The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded (2005) Protein Sci, 14 (8), pp. 1975-1992
Ahmad, E., Rabbani, G., Zaidi, N., Ahmad, B., Khan, R.H., Pollutant-induced modulation in conformation and beta-lactamase activity of human serum albumin (2012) PLoS One, 7 (6), pp. e38372
Angeletti, C., Nichols, J.W., Dithionite quenching rate measurement of the inside-outside membrane bilayer distribution of 7-nitrobenz-2oxa-1,3-diazol-4-yl-labeled phospholipids (1998) Biochemistry, 37 (43), pp. 15114-15119
Ahmad, E., Kamranur Rahman, S., Masood Khan, J., Varshney, A., Hasan Khan, R., Phytolacca americana lectin (Pa-2
pokeweed mitogen): An intrinsically unordered protein and its conversion into partial order at low pH (2010) Biosci Rep, 30 (2), pp. 125-134
Ito, Y., Selenko, P., Cellular structural biology (2010) Curr Opin Struct Biol, 20 (5), pp. 640-648
Carberry, T. P., Tarallo, R., Falanga, A., Dendrimer functionalization with a membrane-interacting domain of herpes simplex virus type 1: Towards intracellular delivery (2012) Chemistry, 18 (43), pp. 13678-1368
Schwarze, S. R., Dowdy, S. F., In vivo protein transduction: Intracellular delivery of biologically active proteins, compounds and DNA (2000) Trends Pharmacol Sci, 21 (2), pp. 45-48
Schwarze, S. R., Ho, A., Vocero-Akbani, A., Dowdy, S. F., In vivo protein transduction: Delivery of a biologically active protein into the mouse (1999) Science, 285 (5433), pp. 1569-1572
Hope, M. J., Bally, M. B., Webb, G., Cullis, P. R., Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential (1985) Biochim Biophys Acta, 812 (1), pp. 55-65
Bolen, E. J., Holloway, P. W., Quenching of tryptophan fluorescence by brominated phospholipid (1990) Biochemistry, 29 (41), pp. 9638-9643
de Kroon, A. I., Soekarjo, M. W., de Gier, J., de Kruijff, B., The role of charge and hydrophobicity in peptide-lipid interaction: A comparative study based on tryptophan fluorescence measurements combined with the use of aqueous and hydrophobic quenchers (1990) Biochemistry, 29 (36), pp. 8229-8240
Bourhis, J. M., Receveur-Brechot, V., Oglesbee, M., The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded (2005) Protein Sci, 14 (8), pp. 1975-1992
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.195, 5-year impact factor: 4.53
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84884186694&partnerID=40&md5=53bf2e1bfe4bfb87866fcbd0a8498862
Keywords: Delivery, Cell Penetrating Peptide, Drug Carrier, Gh625 C Prune, Tat C Prune, Transactivator Protein, Unclassified Drug, Virus Glycoprotein, Article, Carboxy Terminal Sequence, Cell Membrane Permeability, Confocal Microscopy, Controlled Study, Drug Conjugation, Drug Delivery System, Drug Mixture, Herpes Simplex Virus 1, Human, Human Cell, Nonhuman, Surface Charge, Carrier Proteins, Circular Dichroism, Endocytosis, Hela Cells, Intrinsically Disordered Proteins, Neoplasm Proteins, Protein Structure, Tertiary, Recombinant Fusion Proteins, Viral Envelope Proteins,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy
Department of Pharmacy and Interuniversity Research Center on Bioactive Peptides, Federico II University of Naples, Naples, Italy
Molecular Diagnostics and Pharmaceuticals Scarl, Naples, Italy
Special Center for Biotechnology, Federico II University of Naples, Naples, Italy
Center for Advanced Biomaterials for Health Care, Interdisciplinary Research Centre on Biomaterials, Italian Institute of Technology, Naples, Italy
Kedrion S.p.A, Sant'Antimo, Naples, Italy
Department of Experimental Medicine, Federico II University of Naples, Naples, Italy
CEINGE - Advanced Biotechnology Scarl, Naples, Italy
Kedrion S. p. A, Sant'Antimo, Naples, Italy
References:
Carberry, T.P., Tarallo, R., Falanga, A., Dendrimer functionalization with a membrane-interacting domain of herpes simplex virus type 1: Towards intracellular delivery (2012) Chemistry, 18 (43), pp. 13678-1368
Guarnieri, D., Falanga, A., Muscetti, O., Shuttle-mediated nanoparticle delivery to the blood brain barrier (2013) Small, 9 (6), pp. 853-862
Zorko, M., Langel, U., Cell-penetrating peptides: Mechanism and kinetics of cargo delivery (2005) Adv Drug Deliv Rev, 57 (4), pp. 529-545
Deshayes, S., Morris, M.C., Divita, G., Heitz, F., Cell-penetrating peptides: Tools for intracellular delivery of therapeutics (2005) Cell Mol Life Sci, 62 (16), pp. 1839-1849
Chang, M., Chou, J.C., Lee, H.J., Cellular internalization of fluorescent proteins via arginine-rich intracellular delivery peptide in plant cells (2005) Plant Cell Physiol, 46 (3), pp. 482-488
Suzuki, T., Futaki, S., Niwa, M., Tanaka, S., Ueda, K., Sugiura, Y., Possible existence of common internalization mechanisms among arginine-rich peptides (2002) J Biol Chem, 277 (4), pp. 2437-2443
Vives, E., Brodin, P., Lebleu, B., A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus (1997) J Biol Chem, 272 (25), pp. 16010-16017
Schwarze, S.R., Dowdy, S.F., In vivo protein transduction: Intracellular delivery of biologically active proteins, compounds and DNA (2000) Trends Pharmacol Sci, 21 (2), pp. 45-48
Duchardt, F., Fotin-Mleczek, M., Schwarz, H., Fischer, R., Brock, R., A comprehensive model for the cellular uptake of cationic cellpenetrating peptides (2007) Traffic, 8 (7), pp. 848-866
Schwarze, S.R., Ho, A., Vocero-Akbani, A., Dowdy, S.F., In vivo protein transduction: Delivery of a biologically active protein into the mouse (1999) Science, 285 (5433), pp. 1569-1572
Galdiero, S., Vitiello, M., Falanga, A., Cantisani, M., Incoronato, N., Galdiero, M., Intracellular delivery: Exploiting viral membranotropic peptides (2012) Curr Drug Metab, 13 (1), pp. 93-104
Galdiero, S., Falanga, A., Vitiello, G., Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (2010) Biochim Biophys Acta, 1798 (3), pp. 579-591
Galdiero, S., Russo, L., Falanga, A., Structure and orientation of the gH625-644 membrane interacting region of herpes simplex virus type 1 in a membrane mimetic system (2012) Biochemistry, 51 (14), pp. 3121-3128
Tarallo, R., Accardo, A., Falanga, A., Clickable functionalization of liposomes with the gH625 peptide from Herpes simplex virus type I for intracellular drug delivery (2011) Chemistry, 17 (45), pp. 12659-12668
Falanga, A., Tarallo, R., Galdiero, E., Cantisani, M., Galdiero, M., Galdiero, S., Review of a viral peptide nanosystem for intracellular delivery (2013) J Nanophoton, 7 (1), p. 071599
Carotenuto, M., Pedone, E., Diana, D., Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (1351) Sci Rep, 2013, p. 3
Kobayashi, T., Hino, S., Oue, N., Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions (2006) Mol Cell Biol, 26 (3), pp. 898-911
Noguchi, T., Oue, N., Wada, S., h-Prune is an independent prognostic marker for survival in esophageal squamous cell carcinoma (2009) Ann Surg Oncol, 16 (5), pp. 1390-1396
Oue, N., Yoshida, K., Noguchi, T., Sentani, K., Kikuchi, A., Yasui, W., Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer (2007) Cancer Sci, 98 (8), pp. 1198-1205
Massidda, B., Sini, M., Budroni, M., Molecular alterations in keyregulator genes among patients with T4 breast carcinoma (2010) BMC Cancer, 10, p. 458
D'Angelo, A., Garzia, L., Andre, A., Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis (2004) Cancer Cell, 5 (2), pp. 137-149
D'Angelo, A., Zollo, M., Unraveling genes and pathways influenced by H-prune PDE overexpression: A model to study cellular motility (2004) Cell Cycle, 3 (6), pp. 758-761
Marino, N., Zollo, M., Understanding h-prune biology in the fight against cancer (2007) Clin Exp Metastasis, 24 (8), pp. 637-645
Galasso, A., Zollo, M., The Nm23-H1-h-Prune complex in cellular physiology: A 'tip of the iceberg' protein network perspective (2009) Mol Cell Biochem, 329 (1-2), pp. 149-159
Hope, M.J., Bally, M.B., Webb, G., Cullis, P.R., Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential (1985) Biochim Biophys Acta, 812 (1), pp. 55-65
Bolen, E.J., Holloway, P.W., Quenching of tryptophan fluorescence by brominated phospholipid (1990) Biochemistry, 29 (41), pp. 9638-9643
de Kroon, A.I., Soekarjo, M.W., de Gier, J., de Kruijff, B., The role of charge and hydrophobicity in peptide-lipid interaction: A comparative study based on tryptophan fluorescence measurements combined with the use of aqueous and hydrophobic quenchers (1990) Biochemistry, 29 (36), pp. 8229-8240
Bourhis, J.M., Receveur-Brechot, V., Oglesbee, M., The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded (2005) Protein Sci, 14 (8), pp. 1975-1992
Ahmad, E., Rabbani, G., Zaidi, N., Ahmad, B., Khan, R.H., Pollutant-induced modulation in conformation and beta-lactamase activity of human serum albumin (2012) PLoS One, 7 (6), pp. e38372
Angeletti, C., Nichols, J.W., Dithionite quenching rate measurement of the inside-outside membrane bilayer distribution of 7-nitrobenz-2oxa-1,3-diazol-4-yl-labeled phospholipids (1998) Biochemistry, 37 (43), pp. 15114-15119
Ahmad, E., Kamranur Rahman, S., Masood Khan, J., Varshney, A., Hasan Khan, R., Phytolacca americana lectin (Pa-2
pokeweed mitogen): An intrinsically unordered protein and its conversion into partial order at low pH (2010) Biosci Rep, 30 (2), pp. 125-134
Ito, Y., Selenko, P., Cellular structural biology (2010) Curr Opin Struct Biol, 20 (5), pp. 640-648
Carberry, T. P., Tarallo, R., Falanga, A., Dendrimer functionalization with a membrane-interacting domain of herpes simplex virus type 1: Towards intracellular delivery (2012) Chemistry, 18 (43), pp. 13678-1368
Schwarze, S. R., Dowdy, S. F., In vivo protein transduction: Intracellular delivery of biologically active proteins, compounds and DNA (2000) Trends Pharmacol Sci, 21 (2), pp. 45-48
Schwarze, S. R., Ho, A., Vocero-Akbani, A., Dowdy, S. F., In vivo protein transduction: Delivery of a biologically active protein into the mouse (1999) Science, 285 (5433), pp. 1569-1572
Hope, M. J., Bally, M. B., Webb, G., Cullis, P. R., Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential (1985) Biochim Biophys Acta, 812 (1), pp. 55-65
Bolen, E. J., Holloway, P. W., Quenching of tryptophan fluorescence by brominated phospholipid (1990) Biochemistry, 29 (41), pp. 9638-9643
de Kroon, A. I., Soekarjo, M. W., de Gier, J., de Kruijff, B., The role of charge and hydrophobicity in peptide-lipid interaction: A comparative study based on tryptophan fluorescence measurements combined with the use of aqueous and hydrophobic quenchers (1990) Biochemistry, 29 (36), pp. 8229-8240
Bourhis, J. M., Receveur-Brechot, V., Oglesbee, M., The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded (2005) Protein Sci, 14 (8), pp. 1975-1992
gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins
A genetically modified recombinant gH625-c-prune was prepared through conjugation of c-prune with gH625, a peptide encompassing 625-644 residues of the glycoprotein H of herpes simplex virus 1, which has been proved to possess the ability to carry cargo molecules across cell membranes. C-prune is the C-terminal domain of h-prune, overexpressed in breast, colorectal, and gastric cancers, interacting with multiple partners, and representing an ideal target for inhibition of cancer development. Its C-terminal domain results in an intrinsically disordered domain (IDD), and the peculiar properties of gH625 render it an optimal candidate to act as a carrier for this net negatively charged molecule by comparison with the positively charged TAT. A characterization of the recombinant gH625-c-prune fusion protein was conducted by biochemical, cellular biology and confocal microscopy means in comparison with TAT-c-prune. The results showed that the gH625-c-prune exhibited the ability to cross biomembranes, opening a new scenario on the use of gH625 as a novel multifunctional carrier.
A genetically modified recombinant gH625-c-prune was prepared through conjugation of c-prune with gH625, a peptide encompassing 625-644 residues of the glycoprotein H of herpes simplex virus 1, which has been proved to possess the ability to carry cargo molecules across cell membranes. C-prune is the C-terminal domain of h-prune, overexpressed in breast, colorectal, and gastric cancers, interacting with multiple partners, and representing an ideal target for inhibition of cancer development. Its C-terminal domain results in an intrinsically disordered domain (IDD), and the peculiar properties of gH625 render it an optimal candidate to act as a carrier for this net negatively charged molecule by comparison with the positively charged TAT. A characterization of the recombinant gH625-c-prune fusion protein was conducted by biochemical, cellular biology and confocal microscopy means in comparison with TAT-c-prune. The results showed that the gH625-c-prune exhibited the ability to cross biomembranes, opening a new scenario on the use of gH625 as a novel multifunctional carrier.
gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins
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gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (883 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (381 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1044 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (600 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Impact Factor: 3.022
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (550 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (429 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (471 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
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* Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(ε-caprolactone) diblock copolymers: Beyond a paradigm (550 views)
Eur J Pharm Sci (ISSN: 0928-0987, 0928-0987linking), 2018 Jan 1; 111: 177-185.
Impact Factor: 0
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (464 views)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
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Platella C, Riccardi C, Montesarchio D, Roviello GN, Musumeci D
* G-quadruplex-based aptamers against protein targets in therapy and diagnostics (305 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 1872-8006electronic), 2017 May; 1861(5PtB): 1429-1447.
Impact Factor: 3.679
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Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A
* Cross-beta nanostructures based on dinaphthylalanine Gd-conjugates loaded with doxorubicin (413 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Mar 22; 7(1): 307-307.
Impact Factor: 4.122
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Di Matteo A, Franceschini M, Paiardini A, Grottesi A, Chiarella S, Rocchio S, Di Natale C, Marasco D, Vitagliano L, Travaglini-allocatelli C, Federici L
* Structural investigation of Nucleophosmin interaction with the tumor suppressor Fbw7γ (240 views)
Oncogenesis (ISSN: 2157-9024), 2017; 6(9): N/D-N/D.
Impact Factor: 4.722
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Giglio V, Bellia F, Oliveri V, Vecchio G
* Aminocyclodextrin Oligomers as Protective Agents of Protein Aggregation (450 views)
Chempluschem, 2016; 81(7): 660-665.
Impact Factor: 0
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (451 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
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Morelli G, Saviano M, Grieco P
* The renaissance era of peptides in drug discovery at the 14th Naples workshop on bioactive peptides (414 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 321-322.
Impact Factor: 1.951
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (488 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (1013 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (523 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (431 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (488 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (535 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (883 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
View Export to BibTeX Export to EndNote
Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (381 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
View Export to BibTeX Export to EndNote
Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1044 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
View Export to BibTeX Export to EndNote
Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (600 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Impact Factor: 3.022
View Export to BibTeX Export to EndNote
Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
View Export to BibTeX Export to EndNote
Sorriento D, Campanile A, Santulli G, Leggiero E, Pastore L, Trimarco B, Iaccarino G
* A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity (358 views)
Mol Cancermolecular Cancer (ISSN: 1476-4598), 2009; 8: N/D-N/D.
Impact Factor: 4.16
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
View Export to BibTeX Export to EndNote
Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (550 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (429 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
View Export to BibTeX Export to EndNote
Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
View Export to BibTeX Export to EndNote
Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (471 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
View Export to BibTeX Export to EndNote
29 Records (25 excluding Abstracts).
Total impact factor: 90.758 (81.907 excluding Abstracts).
Total 5 year impact factor: 96.825 (83.343 excluding Abstracts).
Total impact factor: 90.758 (81.907 excluding Abstracts).
Total 5 year impact factor: 96.825 (83.343 excluding Abstracts).
445 views. Last view on Friday 27 January 2023, 22:53:25
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