Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (547 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.61, 5-year impact factor: 3.21
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84883156411&partnerID=40&md5=43e90e830d56766875ab8d4f0338ee4a
Keywords: Apoptosis, Autophagy, Polyphenols, Red Wine, U2os Cell Line, Caspase 3, Etoposide, Gallic Acid, Phosphatidylinositol 3 Kinase, Polyphenol Derivative, Protein Kinase B, Protein P53, Reactive Oxygen Metabolite, Antineoplastic Activity, Antioxidant Activity, Antiproliferative Activity, Article, Cancer Inhibition, Cell Count, Cell Damage, Cell Killing, Cell Vacuole, Cell Viability, Concentration Response, Controlled Study, Cytotoxicity, Dealcoholated Red Wine, Enzyme Activation, Enzyme Activity, Enzyme Inhibition, Freeze Drying, Human, Human Cell, Lyophilized Trigaio Red Wine, Osteosarcoma, Phenotype, Protein Function, Sarcoma Cell, Signal Transduction, 2′-7′-Dichlorofluorescein, 2′-7′-Dichlorofluorescein Diacetate, Chroroquine, Damage-Regulated Autophagy Modulator, Dcfh, Dcfh-Da, Ferric Reducing Antioxidant Power, Gallic Acid Equivalent, Ltrw, Reactive Oxygen Species, Tumor, Cell Proliferation, Cell Survival, Proto-Oncogene Proteins C-Akt, Stilbenes, 2-7-Dichlorofluorescein, 2-7-Dichlorofluorescein Diacetate,
Affiliations:
*** IBB - CNR ***
Istituto Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy
Dipartimento di Scienza degli Alimenti, Università degli Studi di Napoli ''Federico II'', 80055 Portici (NA), Italy
References:
Agostini, M., Tucci, P., Melino, G., Cell death pathology: perspective for human diseases (2011) Biochem. Biophys. Res. Commun., 414, pp. 451-45
Anastasiadi, M., Pratsinis, H., Kletsas, D., Skaltsounis, A.L., Haroutounian, S.A., Bioactive non coloured polyphenols content of grapes, wines and vinification by-products: evaluation of the antioxidant activities of their extracts (2010) Food Res. Int., pp. 805-813
Benzie, I.F., Strain, J.J., The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay (1996) Anal. Biochem., 239, pp. 70-76
Bradamante, S., Barenghi, L., Villa, A., Cardiovascular protective effects of resveratrol (2004) Cardiovasc. Drug Rev., 22, pp. 169-188
Briviba, K., Sies, H., Nonenzymatic antioxidant defense systems (1994) Natural Antioxidants in Human Health and Disease, pp. 119-121. , Academic Press Inc., San Diego, CA, B. Frei (Ed.)
Carocho, M., Ferreira, I.C., A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives (2013) Food Chem. Toxicol: Int. J. Publ. Brit. Ind. Biol. Res. Assoc., 51, pp. 15-25
Chao, C., Haque, R., Caan, B.J., Poon, K.Y., Tseng, H.F., Quinn, V.P., Red wine consumption not associated with reduced risk of colorectal cancer (2010) Nutr. Cancer, 62, pp. 849-855
Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P.R., DRAM, a p53-induced modulator of autophagy, is critical for apoptosis (2006) Cell, 126, pp. 121-134
de la Lastra, C.A., Villegas, I., Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications (2007) Biochem. Soc. Trans., 35, pp. 1156-1160
Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis (2006) Cancer Cell, 10, pp. 51-64
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Dewaele, M., Maes, H., Agostinis, P., ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy (2010) Autophagy, 6, pp. 838-854
Forester, S.C., Lambert, J.D., The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention (2011) Mol. Nutr. Food Res., 55, pp. 844-854
Frampton, A.E., Stebbing, J., Raising a glass of red wine against cancer, or not? (2012) Lancet Oncol., 13, pp. 669-670
Galluzzi, L., Maiuri, M.C., Vitale, I., Zischka, H., Castedo, M., Zitvogel, L., Kroemer, G., Cell death modalities: classification and pathophysiological implications (2007) Cell Death Differ., 14, pp. 1237-1243
Giacosa, A., Adam-Blondon, A.F., Baer-Sinnott, S., Barale, R., Bavaresco, L., Di Gaspero, G., Alcohol and wine in relation to cancer and other diseases (2012) Eur. J. Cancer Prev., 21, pp. 103-108
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Halliwell, B., The wanderings of a free radical (2009) Free Radic. Biol. Med., 46, pp. 531-542
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Hao, H.D., He, L.R., Mechanisms of cardiovascular protection by resveratrol (2004) J. Med. Food, 7, pp. 290-298
Hou, D.X., Potential mechanisms of cancer chemoprevention by anthocyanins (2003) Curr. Mol. Med., 3, pp. 149-159
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Jang, Y.J., Kang, N.J., Lee, K.W., Lee, H.J., Protective effects of red wine flavonols on 4-hydroxynonenal-induced apoptosis in PC12 cells (2009) Ann. N. Y. Acad. Sci., 1171, pp. 170-175
Katalinić, V., Milos, M., Moduna, D., Musić, I., Boban, M., Antioxidant effectiveness of selected wines in comparison with (+)-catechin (2004) Food Chem., 86, pp. 593-600
Kim, M.J., Kim, Y.J., Park, H.J., Chung, J.H., Leem, K.H., Kim, H.K., Apoptotic effect of red wine polyphenols on human colon cancer SNU-C4 cells (2006) Food Chem. Toxicol., 44, pp. 898-902
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de la Lastra, C. A., Villegas, I., Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications (2007) Biochem. Soc. Trans., 35, pp. 1156-1160
Forester, S. C., Lambert, J. D., The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention (2011) Mol. Nutr. Food Res., 55, pp. 844-854
Frampton, A. E., Stebbing, J., Raising a glass of red wine against cancer, or not? (2012) Lancet Oncol., 13, pp. 669-670
Hao, H. D., He, L. R., Mechanisms of cardiovascular protection by resveratrol (2004) J. Med. Food, 7, pp. 290-298
Hou, D. X., Potential mechanisms of cancer chemoprevention by anthocyanins (2003) Curr. Mol. Med., 3, pp. 149-159
Jang, Y. J., Kang, N. J., Lee, K. W., Lee, H. J., Protective effects of red wine flavonols on 4-hydroxynonenal-induced apoptosis in PC12 cells (2009) Ann. N. Y. Acad. Sci., 1171, pp. 170-175
Katalini, V., Milos, M., Moduna, D., Musi, I., Boban, M., Antioxidant effectiveness of selected wines in comparison with (+) -catechin (2004) Food Chem., 86, pp. 593-600
Kim, M. J., Kim, Y. J., Park, H. J., Chung, J. H., Leem, K. H., Kim, H. K., Apoptotic effect of red wine polyphenols on human colon cancer SNU-C4 cells (2006) Food Chem. Toxicol., 44, pp. 898-902
Klappan, A. K., Hones, S., Mylonas, I., Bruning, A., Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity (2012) Histochem. Cell Biol., 137, pp. 25-36
Klionsky, D. J., Autophagy: from phenomenology to molecular understanding in less than a decade (2007) Nat. Rev. Mol. Cell Biol., 8, pp. 931-937
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Guidelines for the use and interpretation of assays for monitoring autophagy (2012) Autophagy, 8, pp. 445-544
Lachenmeier, D. W., Rehm, J., Moderate red wine drinking does not help cut women's breast cancer risk (2012) J Womens Health (Larchmt), 21, pp. 469-470
Landete, J. M., Updated knowledge about polyphenols: functions, bioavailability, metabolism, and health (2012) Crit. Rev. Food Sci. Nutr., 52, pp. 936-948
Lee, K. W., Kang, N. J., Heo, Y. S., Rogozin, E. A., Pugliese, A., Hwang, M. K., Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine (2008) Cancer Res., 68, pp. 946-955
Maiuri, M. C., Zalckvar, E., Kimchi, A., Kroemer, G., Self-eating and self-killing: crosstalk between autophagy and apoptosis (2007) Nat. Rev. Mol. Cell Biol., 8, pp. 741-752
Martelli, A. M., Tabellini, G., Bressanin, D., Ognibene, A., Goto, K., Cocco, L., Evangelisti, C., The emerging multiple roles of nuclear Akt (2012) Biochim. Biophys. Acta, 1823, pp. 2168-2178
Russo, G. L., Ins and outs of dietary phytochemicals in cancer chemoprevention (2007) Biochem. Pharmacol., 74, pp. 533-544
Shanafelt, T. D., Call, T. G., Zent, C. S., LaPlant, B., Bowen, D. A., Roos, M., Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia (2009) J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol., 27, pp. 3808-3814
Singleton, V. L., Rossi, J. A., Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents (1965) Am. J. Enol. Vitic., 16, pp. 144-158
Surh, Y. J., Cancer chemoprevention with dietary phytochemicals (2003) Nat. Rev. Cancer, 3, pp. 768-780
van Dorsten, F. A., Grun, C. H., van Velzen, E. J., Jacobs, D. M., Draijer, R., van Duynhoven, J. P., The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics (2010) Mol. Nutr. Food Res., 54, pp. 897-908
Vargas, A. J., Burd, R., Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management (2010) Nutr. Rev., 68, pp. 418-428
Wang, S. Y., Yu, Q. J., Zhang, R. D., Liu, B., Core signaling pathways of survival/death in autophagy-related cancer networks (2011) Int. J. Biochem. Cell Biol., 43, pp. 1263-1266
Wang, R. C., Wei, Y., An, Z., Zou, Z., Xiao, G., Bhagat, G., Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation (2012) Science, 338, pp. 956-959
Wan-Ibrahim, W. I., Sidik, K., Kuppusamy, U. R., A high antioxidant level in edible plants is associated with genotoxic properties (2010) Food Chem., 122, pp. 1139-1144
Wattenberg, L. W., Chemoprevention of cancer (1985) Cancer Res., 45, pp. 1-8
Wong, R. S., Apoptosis in cancer: from pathogenesis to treatment (2011) J. Exp. Clin. Cancer Res., 30, pp. 87-101
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.61, 5-year impact factor: 3.21
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84883156411&partnerID=40&md5=43e90e830d56766875ab8d4f0338ee4a
Keywords: Apoptosis, Autophagy, Polyphenols, Red Wine, U2os Cell Line, Caspase 3, Etoposide, Gallic Acid, Phosphatidylinositol 3 Kinase, Polyphenol Derivative, Protein Kinase B, Protein P53, Reactive Oxygen Metabolite, Antineoplastic Activity, Antioxidant Activity, Antiproliferative Activity, Article, Cancer Inhibition, Cell Count, Cell Damage, Cell Killing, Cell Vacuole, Cell Viability, Concentration Response, Controlled Study, Cytotoxicity, Dealcoholated Red Wine, Enzyme Activation, Enzyme Activity, Enzyme Inhibition, Freeze Drying, Human, Human Cell, Lyophilized Trigaio Red Wine, Osteosarcoma, Phenotype, Protein Function, Sarcoma Cell, Signal Transduction, 2′-7′-Dichlorofluorescein, 2′-7′-Dichlorofluorescein Diacetate, Chroroquine, Damage-Regulated Autophagy Modulator, Dcfh, Dcfh-Da, Ferric Reducing Antioxidant Power, Gallic Acid Equivalent, Ltrw, Reactive Oxygen Species, Tumor, Cell Proliferation, Cell Survival, Proto-Oncogene Proteins C-Akt, Stilbenes, 2-7-Dichlorofluorescein, 2-7-Dichlorofluorescein Diacetate,
Affiliations:
*** IBB - CNR ***
Istituto Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy
Dipartimento di Scienza degli Alimenti, Università degli Studi di Napoli ''Federico II'', 80055 Portici (NA), Italy
References:
Agostini, M., Tucci, P., Melino, G., Cell death pathology: perspective for human diseases (2011) Biochem. Biophys. Res. Commun., 414, pp. 451-45
Anastasiadi, M., Pratsinis, H., Kletsas, D., Skaltsounis, A.L., Haroutounian, S.A., Bioactive non coloured polyphenols content of grapes, wines and vinification by-products: evaluation of the antioxidant activities of their extracts (2010) Food Res. Int., pp. 805-813
Benzie, I.F., Strain, J.J., The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay (1996) Anal. Biochem., 239, pp. 70-76
Bradamante, S., Barenghi, L., Villa, A., Cardiovascular protective effects of resveratrol (2004) Cardiovasc. Drug Rev., 22, pp. 169-188
Briviba, K., Sies, H., Nonenzymatic antioxidant defense systems (1994) Natural Antioxidants in Human Health and Disease, pp. 119-121. , Academic Press Inc., San Diego, CA, B. Frei (Ed.)
Carocho, M., Ferreira, I.C., A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives (2013) Food Chem. Toxicol: Int. J. Publ. Brit. Ind. Biol. Res. Assoc., 51, pp. 15-25
Chao, C., Haque, R., Caan, B.J., Poon, K.Y., Tseng, H.F., Quinn, V.P., Red wine consumption not associated with reduced risk of colorectal cancer (2010) Nutr. Cancer, 62, pp. 849-855
Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P.R., DRAM, a p53-induced modulator of autophagy, is critical for apoptosis (2006) Cell, 126, pp. 121-134
de la Lastra, C.A., Villegas, I., Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications (2007) Biochem. Soc. Trans., 35, pp. 1156-1160
Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis (2006) Cancer Cell, 10, pp. 51-64
Degtyarev, M., De Maziere, A., Orr, C., Lin, J., Lee, B.B., Tien, J.Y., Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents (2008) J. Cell Biol., 183, pp. 101-116
Dewaele, M., Maes, H., Agostinis, P., ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy (2010) Autophagy, 6, pp. 838-854
Forester, S.C., Lambert, J.D., The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention (2011) Mol. Nutr. Food Res., 55, pp. 844-854
Frampton, A.E., Stebbing, J., Raising a glass of red wine against cancer, or not? (2012) Lancet Oncol., 13, pp. 669-670
Galluzzi, L., Maiuri, M.C., Vitale, I., Zischka, H., Castedo, M., Zitvogel, L., Kroemer, G., Cell death modalities: classification and pathophysiological implications (2007) Cell Death Differ., 14, pp. 1237-1243
Giacosa, A., Adam-Blondon, A.F., Baer-Sinnott, S., Barale, R., Bavaresco, L., Di Gaspero, G., Alcohol and wine in relation to cancer and other diseases (2012) Eur. J. Cancer Prev., 21, pp. 103-108
Greenwald, P., Cancer chemoprevention (2004) BMJ, 324, pp. 714-718
Halliwell, B., The wanderings of a free radical (2009) Free Radic. Biol. Med., 46, pp. 531-542
Halliwell, B., Whiteman, M., Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? (2004) Br. J. Pharmacol., 142, pp. 231-255
Hao, H.D., He, L.R., Mechanisms of cardiovascular protection by resveratrol (2004) J. Med. Food, 7, pp. 290-298
Hou, D.X., Potential mechanisms of cancer chemoprevention by anthocyanins (2003) Curr. Mol. Med., 3, pp. 149-159
Jang, M., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W., Cancer chemopreventive activity of resveratrol, a natural product derived from grapes (1997) Science, 275, pp. 218-220
Jang, Y.J., Kang, N.J., Lee, K.W., Lee, H.J., Protective effects of red wine flavonols on 4-hydroxynonenal-induced apoptosis in PC12 cells (2009) Ann. N. Y. Acad. Sci., 1171, pp. 170-175
Katalinić, V., Milos, M., Moduna, D., Musić, I., Boban, M., Antioxidant effectiveness of selected wines in comparison with (+)-catechin (2004) Food Chem., 86, pp. 593-600
Kim, M.J., Kim, Y.J., Park, H.J., Chung, J.H., Leem, K.H., Kim, H.K., Apoptotic effect of red wine polyphenols on human colon cancer SNU-C4 cells (2006) Food Chem. Toxicol., 44, pp. 898-902
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Lachenmeier, D. W., Rehm, J., Moderate red wine drinking does not help cut women's breast cancer risk (2012) J Womens Health (Larchmt), 21, pp. 469-470
Landete, J. M., Updated knowledge about polyphenols: functions, bioavailability, metabolism, and health (2012) Crit. Rev. Food Sci. Nutr., 52, pp. 936-948
Lee, K. W., Kang, N. J., Heo, Y. S., Rogozin, E. A., Pugliese, A., Hwang, M. K., Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine (2008) Cancer Res., 68, pp. 946-955
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Russo, G. L., Ins and outs of dietary phytochemicals in cancer chemoprevention (2007) Biochem. Pharmacol., 74, pp. 533-544
Shanafelt, T. D., Call, T. G., Zent, C. S., LaPlant, B., Bowen, D. A., Roos, M., Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia (2009) J. Clin. Oncol.: Off. J. Am. Soc. Clin. Oncol., 27, pp. 3808-3814
Singleton, V. L., Rossi, J. A., Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents (1965) Am. J. Enol. Vitic., 16, pp. 144-158
Surh, Y. J., Cancer chemoprevention with dietary phytochemicals (2003) Nat. Rev. Cancer, 3, pp. 768-780
van Dorsten, F. A., Grun, C. H., van Velzen, E. J., Jacobs, D. M., Draijer, R., van Duynhoven, J. P., The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics (2010) Mol. Nutr. Food Res., 54, pp. 897-908
Vargas, A. J., Burd, R., Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management (2010) Nutr. Rev., 68, pp. 418-428
Wang, S. Y., Yu, Q. J., Zhang, R. D., Liu, B., Core signaling pathways of survival/death in autophagy-related cancer networks (2011) Int. J. Biochem. Cell Biol., 43, pp. 1263-1266
Wang, R. C., Wei, Y., An, Z., Zou, Z., Xiao, G., Bhagat, G., Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation (2012) Science, 338, pp. 956-959
Wan-Ibrahim, W. I., Sidik, K., Kuppusamy, U. R., A high antioxidant level in edible plants is associated with genotoxic properties (2010) Food Chem., 122, pp. 1139-1144
Wattenberg, L. W., Chemoprevention of cancer (1985) Cancer Res., 45, pp. 1-8
Wong, R. S., Apoptosis in cancer: from pathogenesis to treatment (2011) J. Exp. Clin. Cancer Res., 30, pp. 87-101
Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line
Until recently, the supposed preventive effects of red wine against cardiovascular diseases, the so-called "French Paradox", has been associated to its antioxidant properties. The interest in the anticancer capacity of polyphenols present in red wine strongly increased consequently to the enormous number of studies on resveratrol. In this study, using lyophilized red wine, we present evidence that its anticancer effect in a cellular model is mediated by apoptotic and autophagic cell death. Using a human osteosarcoma cell line, U2Os, we found that the lyophilized red wine was cytotoxic in a dose-dependent manner with a maximum effect in the range of 100-200μg/ml equivalents of gallic acid. A mixed phenotype of types I/II cell death was evidenced by means of specific assays following treatment of U2Os with lyophilized red wine, e.g., autophagy and apoptosis. We found that cell death induced by lyophilized red wine proceeded through a mechanism independent from its anti-oxidant activity and involving the inhibition of PI3K/Akt kinase signaling. Considering the relative low concentration of each single bioactive compound in lyophilized red wine, our study suggests the activation of synergistic mechanism able to inhibit growth in malignant cells. © 2013 Elsevier Ltd.
Until recently, the supposed preventive effects of red wine against cardiovascular diseases, the so-called "French Paradox", has been associated to its antioxidant properties. The interest in the anticancer capacity of polyphenols present in red wine strongly increased consequently to the enormous number of studies on resveratrol. In this study, using lyophilized red wine, we present evidence that its anticancer effect in a cellular model is mediated by apoptotic and autophagic cell death. Using a human osteosarcoma cell line, U2Os, we found that the lyophilized red wine was cytotoxic in a dose-dependent manner with a maximum effect in the range of 100-200μg/ml equivalents of gallic acid. A mixed phenotype of types I/II cell death was evidenced by means of specific assays following treatment of U2Os with lyophilized red wine, e.g., autophagy and apoptosis. We found that cell death induced by lyophilized red wine proceeded through a mechanism independent from its anti-oxidant activity and involving the inhibition of PI3K/Akt kinase signaling. Considering the relative low concentration of each single bioactive compound in lyophilized red wine, our study suggests the activation of synergistic mechanism able to inhibit growth in malignant cells. © 2013 Elsevier Ltd.
Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line
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Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line
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Impact Factor: 2.76
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Mercurio FA, Scognamiglio PL, Di Natale C, Marasco D, Pellecchia M, Leone M
* Cd And Nmr Conformational Studies Of A Peptide Encompassing The Mid Loop Interface Of Ship2-Sam (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Nov; 101(11): 1088-1098.
Impact Factor: 2.385
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (402 views)
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (530 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (900 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (805 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Fiory F, Alberobello AT, Miele C, Oriente F, Esposito I, Corbo V, Ruvo M, Tizzano B, Rasmussen TE, Gammeltoft S, Formisano P, Beguinot F
* Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling (462 views)
Mol Cell Biol (ISSN: 0270-7306, 1098-5549), 2005 Dec; 25(24): 10803-10814.
Impact Factor: 7.093
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Tedesco I, Nappo A, Petitto F, Iacomino G, Nazzaro F, Palumbo R, Russo Gian L
* Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line (752 views)
Nutr Cancer (ISSN: 0163-5581), 2005; 52(1): 74-83.
Impact Factor: 2.426
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (395 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (616 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
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17 Records (15 excluding Abstracts).
Total impact factor: 79.229 (69.492 excluding Abstracts).
Total 5 year impact factor: 86.46 (76.577 excluding Abstracts).
Total impact factor: 79.229 (69.492 excluding Abstracts).
Total 5 year impact factor: 86.46 (76.577 excluding Abstracts).
547 views. Last view on Thursday 08 June 2023, 9:55:55
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