Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (637 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
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Paper type: Journal Article,
Impact factor: 2.61, 5-year impact factor: 3.21
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84883156411&partnerID=40&md5=43e90e830d56766875ab8d4f0338ee4a
Keywords: Apoptosis, Autophagy, Polyphenols, Red Wine, U2os Cell Line, Caspase 3, Etoposide, Gallic Acid, Phosphatidylinositol 3 Kinase, Polyphenol Derivative, Protein Kinase B, Protein P53, Reactive Oxygen Metabolite, Antineoplastic Activity, Antioxidant Activity, Antiproliferative Activity, Article, Cancer Inhibition, Cell Count, Cell Damage, Cell Killing, Cell Vacuole, Cell Viability, Concentration Response, Controlled Study, Cytotoxicity, Dealcoholated Red Wine, Enzyme Activation, Enzyme Activity, Enzyme Inhibition, Freeze Drying, Human, Human Cell, Lyophilized Trigaio Red Wine, Osteosarcoma, Phenotype, Protein Function, Sarcoma Cell, Signal Transduction, 2′-7′-Dichlorofluorescein, 2′-7′-Dichlorofluorescein Diacetate, Chroroquine, Damage-Regulated Autophagy Modulator, Dcfh, Dcfh-Da, Ferric Reducing Antioxidant Power, Gallic Acid Equivalent, Ltrw, Reactive Oxygen Species, Tumor, Cell Proliferation, Cell Survival, Proto-Oncogene Proteins C-Akt, Stilbenes, 2-7-Dichlorofluorescein, 2-7-Dichlorofluorescein Diacetate,
Affiliations:
*** IBB - CNR ***
Istituto Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy
Dipartimento di Scienza degli Alimenti, Università degli Studi di Napoli ''Federico II'', 80055 Portici (NA), Italy
References:
Not available.
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.61, 5-year impact factor: 3.21
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84883156411&partnerID=40&md5=43e90e830d56766875ab8d4f0338ee4a
Keywords: Apoptosis, Autophagy, Polyphenols, Red Wine, U2os Cell Line, Caspase 3, Etoposide, Gallic Acid, Phosphatidylinositol 3 Kinase, Polyphenol Derivative, Protein Kinase B, Protein P53, Reactive Oxygen Metabolite, Antineoplastic Activity, Antioxidant Activity, Antiproliferative Activity, Article, Cancer Inhibition, Cell Count, Cell Damage, Cell Killing, Cell Vacuole, Cell Viability, Concentration Response, Controlled Study, Cytotoxicity, Dealcoholated Red Wine, Enzyme Activation, Enzyme Activity, Enzyme Inhibition, Freeze Drying, Human, Human Cell, Lyophilized Trigaio Red Wine, Osteosarcoma, Phenotype, Protein Function, Sarcoma Cell, Signal Transduction, 2′-7′-Dichlorofluorescein, 2′-7′-Dichlorofluorescein Diacetate, Chroroquine, Damage-Regulated Autophagy Modulator, Dcfh, Dcfh-Da, Ferric Reducing Antioxidant Power, Gallic Acid Equivalent, Ltrw, Reactive Oxygen Species, Tumor, Cell Proliferation, Cell Survival, Proto-Oncogene Proteins C-Akt, Stilbenes, 2-7-Dichlorofluorescein, 2-7-Dichlorofluorescein Diacetate,
Affiliations:
*** IBB - CNR ***
Istituto Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy
Dipartimento di Scienza degli Alimenti, Università degli Studi di Napoli ''Federico II'', 80055 Portici (NA), Italy
References:
Not available.
Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line
Until recently, the supposed preventive effects of red wine against cardiovascular diseases, the so-called "French Paradox", has been associated to its antioxidant properties. The interest in the anticancer capacity of polyphenols present in red wine strongly increased consequently to the enormous number of studies on resveratrol. In this study, using lyophilized red wine, we present evidence that its anticancer effect in a cellular model is mediated by apoptotic and autophagic cell death. Using a human osteosarcoma cell line, U2Os, we found that the lyophilized red wine was cytotoxic in a dose-dependent manner with a maximum effect in the range of 100-200μg/ml equivalents of gallic acid. A mixed phenotype of types I/II cell death was evidenced by means of specific assays following treatment of U2Os with lyophilized red wine, e.g., autophagy and apoptosis. We found that cell death induced by lyophilized red wine proceeded through a mechanism independent from its anti-oxidant activity and involving the inhibition of PI3K/Akt kinase signaling. Considering the relative low concentration of each single bioactive compound in lyophilized red wine, our study suggests the activation of synergistic mechanism able to inhibit growth in malignant cells. © 2013 Elsevier Ltd.
Until recently, the supposed preventive effects of red wine against cardiovascular diseases, the so-called "French Paradox", has been associated to its antioxidant properties. The interest in the anticancer capacity of polyphenols present in red wine strongly increased consequently to the enormous number of studies on resveratrol. In this study, using lyophilized red wine, we present evidence that its anticancer effect in a cellular model is mediated by apoptotic and autophagic cell death. Using a human osteosarcoma cell line, U2Os, we found that the lyophilized red wine was cytotoxic in a dose-dependent manner with a maximum effect in the range of 100-200μg/ml equivalents of gallic acid. A mixed phenotype of types I/II cell death was evidenced by means of specific assays following treatment of U2Os with lyophilized red wine, e.g., autophagy and apoptosis. We found that cell death induced by lyophilized red wine proceeded through a mechanism independent from its anti-oxidant activity and involving the inhibition of PI3K/Akt kinase signaling. Considering the relative low concentration of each single bioactive compound in lyophilized red wine, our study suggests the activation of synergistic mechanism able to inhibit growth in malignant cells. © 2013 Elsevier Ltd.
Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line
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Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.426
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
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J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
View Export to BibTeX Export to EndNote
17 Records (15 excluding Abstracts).
Total impact factor: 79.229 (69.492 excluding Abstracts).
Total 5 year impact factor: 86.46 (76.577 excluding Abstracts).
Total impact factor: 79.229 (69.492 excluding Abstracts).
Total 5 year impact factor: 86.46 (76.577 excluding Abstracts).
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