Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (394 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
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Paper type: Journal Article,
Impact factor: 3.463, 5-year impact factor: 4.027
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84866764636&partnerID=40&md5=19173f929bbc89b03146159878cfb79d
Keywords: Bombesin Peptide, Doxorubicin Delivery, Gastrin-Releasing Peptide Receptors, Pc-3 Cells, Theranostic Applications, 2 Distearoyl Sn Glycero 3 Phosphocholine, Bombesin Receptor, Macrogol, Monomer, Mony Bn, Phospholipid, Unclassified Drug, 2 Distearoyllecithin, 2-Distearoyllecithin, Antineoplastic Agent, Bombesin (7 14), Bombesin (7-14), Drug Carrier, Drug Derivative, Liposome, Pentetic Acid, Peptide Fragment, Phosphatidylcholine, Surfactant, Animal Experiment, Animal Model, Antineoplastic Activity, Article, Binding Affinity, Cancer Cell Culture, Cancer Cell Destruction, Cancer Inhibition, Cell Adhesion, Cell Survival, Chemical Composition, Controlled Study, Cytotoxicity Test, Encapsulation, Female, Human, Human Cell, In Vitro Study, In Vivo Study, Liposomal Delivery, Mouse, Nonhuman, Prostate Cancer, Protein Expression, Protein Localization, Protein Targeting, Tumor Xenograft, Upregulation, Bagg Albino Mouse, Chemistry, Drug Antagonism, Drug Delivery System, Drug Screening, Metabolism, Nanomedicine, Nude Mouse, Pathology, Prostate Tumor, Tumor Cell Line, Inbred Balb C, Prostatic Neoplasms, Surface-Active Agents, Xenograft Model Antitumor Assays,
Affiliations:
*** IBB - CNR ***
CIRPeB, Department of Biological Sciences and IBB CNR, University of Naples 'Federico II', Napoli, Italy
Department of Pharmaceutical Chemistry, University of Naples 'Federico II', Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione 'G. Pascale', Italy
Department of Experimental Pharmacology, University of Naples 'Federico II', Napoli, Italy
References:
Not available.
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.463, 5-year impact factor: 4.027
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84866764636&partnerID=40&md5=19173f929bbc89b03146159878cfb79d
Keywords: Bombesin Peptide, Doxorubicin Delivery, Gastrin-Releasing Peptide Receptors, Pc-3 Cells, Theranostic Applications, 2 Distearoyl Sn Glycero 3 Phosphocholine, Bombesin Receptor, Macrogol, Monomer, Mony Bn, Phospholipid, Unclassified Drug, 2 Distearoyllecithin, 2-Distearoyllecithin, Antineoplastic Agent, Bombesin (7 14), Bombesin (7-14), Drug Carrier, Drug Derivative, Liposome, Pentetic Acid, Peptide Fragment, Phosphatidylcholine, Surfactant, Animal Experiment, Animal Model, Antineoplastic Activity, Article, Binding Affinity, Cancer Cell Culture, Cancer Cell Destruction, Cancer Inhibition, Cell Adhesion, Cell Survival, Chemical Composition, Controlled Study, Cytotoxicity Test, Encapsulation, Female, Human, Human Cell, In Vitro Study, In Vivo Study, Liposomal Delivery, Mouse, Nonhuman, Prostate Cancer, Protein Expression, Protein Localization, Protein Targeting, Tumor Xenograft, Upregulation, Bagg Albino Mouse, Chemistry, Drug Antagonism, Drug Delivery System, Drug Screening, Metabolism, Nanomedicine, Nude Mouse, Pathology, Prostate Tumor, Tumor Cell Line, Inbred Balb C, Prostatic Neoplasms, Surface-Active Agents, Xenograft Model Antitumor Assays,
Affiliations:
*** IBB - CNR ***
CIRPeB, Department of Biological Sciences and IBB CNR, University of Naples 'Federico II', Napoli, Italy
Department of Pharmaceutical Chemistry, University of Naples 'Federico II', Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione 'G. Pascale', Italy
Department of Experimental Pharmacology, University of Naples 'Federico II', Napoli, Italy
References:
Not available.
Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent
Objectives: Drug delivery systems consisting of liposomes displaying a cell surface receptor-targeting peptide are being developed to specifically deliver chemotherapeutic drugs to tumors overexpressing a target receptor. This study addresses novel liposome composition approaches to specifically target tissues overexpressing bombesin (BN) receptors. Methods: A new amphiphilic peptide derivative (MonY-BN) containing the BN(7-14) peptide, the DTPA (diethylenetriaminepentaacetate) chelating agent, a hydrophobic moiety with two C18 alkyl chains, and polyethylene glycol spacers, has been synthesized by solid-phase methods. Liposomes have been generated by co-aggregation of MonY-BN with 1,2-distearoyl-sn-glycero- 3-phosphocholine (DSPC). The structural and biological properties of these new target-selective drug-delivery systems have been characterized. Results: Liposomes with a DSPC/MonY-BN (97/3 molar ratio) composition showed a diameter of 145.5±31.5 nm and a polydispersity index of 0.20 ± 0.05. High doxorubicin (Dox) loading was obtained with the remote pH gradient method using citrate as the inner buffer. Specific binding to PC-3 cells of DSPC/MonY-BN liposomes was obtained (2.7% ± 0.3%, at 37°C), compared with peptide-free DSPC liposomes (1.4% ± 0.2% at 37°C). Incubation of cells with DSPC/ MonY-BN/Dox showed significantly lower cell survival compared with DSPC/Dox-treated cells, in the presence of 100 ng/mL and 300 ng/mL drug amounts, in cytotoxicity experiments. Intravenous treatment of PC-3 xenograft-bearing mice with DSPC/MonY-BN/Dox at 10 mg/kg Dox dose produced higher tumour growth inhibition (60%) compared with nonspecific DSPC/ Dox liposomes (36%) relative to control animals. Conclusion: The structural and loading properties of DSPC/MonY-BN liposomes along with the observed in-vitro and in-vivo activity are encouraging for further development of this approach for target-specific cancer chemotherapy. © 2012 Accardo et al, publisher and licensee Dove Medical Press Ltd.
Objectives: Drug delivery systems consisting of liposomes displaying a cell surface receptor-targeting peptide are being developed to specifically deliver chemotherapeutic drugs to tumors overexpressing a target receptor. This study addresses novel liposome composition approaches to specifically target tissues overexpressing bombesin (BN) receptors. Methods: A new amphiphilic peptide derivative (MonY-BN) containing the BN(7-14) peptide, the DTPA (diethylenetriaminepentaacetate) chelating agent, a hydrophobic moiety with two C18 alkyl chains, and polyethylene glycol spacers, has been synthesized by solid-phase methods. Liposomes have been generated by co-aggregation of MonY-BN with 1,2-distearoyl-sn-glycero- 3-phosphocholine (DSPC). The structural and biological properties of these new target-selective drug-delivery systems have been characterized. Results: Liposomes with a DSPC/MonY-BN (97/3 molar ratio) composition showed a diameter of 145.5±31.5 nm and a polydispersity index of 0.20 ± 0.05. High doxorubicin (Dox) loading was obtained with the remote pH gradient method using citrate as the inner buffer. Specific binding to PC-3 cells of DSPC/MonY-BN liposomes was obtained (2.7% ± 0.3%, at 37°C), compared with peptide-free DSPC liposomes (1.4% ± 0.2% at 37°C). Incubation of cells with DSPC/ MonY-BN/Dox showed significantly lower cell survival compared with DSPC/Dox-treated cells, in the presence of 100 ng/mL and 300 ng/mL drug amounts, in cytotoxicity experiments. Intravenous treatment of PC-3 xenograft-bearing mice with DSPC/MonY-BN/Dox at 10 mg/kg Dox dose produced higher tumour growth inhibition (60%) compared with nonspecific DSPC/ Dox liposomes (36%) relative to control animals. Conclusion: The structural and loading properties of DSPC/MonY-BN liposomes along with the observed in-vitro and in-vivo activity are encouraging for further development of this approach for target-specific cancer chemotherapy. © 2012 Accardo et al, publisher and licensee Dove Medical Press Ltd.
Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent
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Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent
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Fik-jaskółka MA, Mkrtchyan AF, Saghyan AS, Palumbo R, Belter A, Hayriyan LA, Simonyan H, Roviello V, Roviello GN
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Impact Factor: 3.232
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Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (435 views)
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Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (437 views)
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Impact Factor: 3.687
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Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (600 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (419 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
View Export to BibTeX Export to EndNote
* Spectroscopic and SEM evidences for G4-DNA binding by a synthetic alkyne-containing amino acid with anticancer activity (245 views) (PDF 77 views)
Spectrochim Acta A (ISSN: 1386-1425linking), 2020 Mar 15; 229: 117884-117884.
Impact Factor: 3.232
View Export to BibTeX Export to EndNote
Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (435 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jan; 121: 77-88.
Impact Factor: 4.784
View Export to BibTeX Export to EndNote
Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (437 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
View Export to BibTeX Export to EndNote
Ringhieri P, Iannitti R, Nardon C, Palumbo R, Fregona D, Morelli G, Accardo A
* Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (600 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Impact Factor: 3.65
View Export to BibTeX Export to EndNote
Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (419 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
View Export to BibTeX Export to EndNote
5 Records (5 excluding Abstracts).
Total impact factor: 18.121 (18.121 excluding Abstracts).
Total 5 year impact factor: 18.186 (18.186 excluding Abstracts).
Total impact factor: 18.121 (18.121 excluding Abstracts).
Total 5 year impact factor: 18.186 (18.186 excluding Abstracts).
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