Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells(517 views) Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Keywords: Breast Cancer, Cell Signaling, Growth Factors And Receptors, Oncogenes, Tumor Promotion And Progression, Epidermal Growth Factor Receptor 2, Insulin Receptor Substrate 1, Liposome, Mitogen Activated Protein Kinase 1, P 1257, Phosphatidylinositol 3 Kinase, Phosphatidylinositol 3 Kinase Inhibitor, Phosphopeptide 1257, Protein P85, Trastuzumab, Unclassified Drug, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Antineoplastic Activity, Apoptosis, Article, Cancer Cell Culture, Cell Death, Cell Proliferation, Controlled Study, Drug Efficacy, Electroporation, Enzyme Activity, Enzyme Inhibition, Enzyme Phosphorylation, Female, Gene Overexpression, Human, Human Cell, Human Tissue, In Vitro Study, In Vivo Gene Transfer, Mouse, Nonhuman, Priority Journal, Protein Expression, Protein Function, Protein Protein Interaction, Protein Targeting, Treatment Response, Tumor Growth, Tumor Volume, Antineoplastic Agents, Breast Neoplasms, Catalytic Domain, Down-Regulation, Enzyme Inhibitors, Insulin Receptor Substrate Proteins, Scid, Phosphatidylinositol 3-Kinases, Protein Binding, Proto-Oncogene Proteins C-Akt, Erbb-3,
Affiliations: *** IBB - CNR ***
Department of Experimental Oncology, Regina National Elena Cancer Institute, Molecular Oncogenesis Laboratory, Via delle Messi d'Oro 156, 0158 Rome, Italy
Regina Elena National Cancer Institute, SAFU, Via delle Messi d'Oro 156, Rome, Italy
Department of Pathology, Regina Elena Cancer Institute, Via E. Chianesi 54, Rome, Italy
Department of Biological Sciences, CIRPeB, University of Naples 'Federico II' and IBB CNR, Via Giovanni Paladino 39, Naples, Italy
Department of Oncology, Regina Elena Cancer Institute, Via E. Chianesi 54, Rome, Italy
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Yuan, T. L., Canntley, L. C., PI3K pathway alteration in cancer: Variation on a theme (2008) Oncogene, 27, pp. 5497-5510
Arteaga, C. L., Sliwkowski, M. X., Osborne, C. K., Perez, E. A., Puglisi, F., Gianni, L., Treatment of HER2-positive breast cancer: Current status and future prospective (2011) Nat Rev Clin Oncol, 9, pp. 16-32
Di Fiore, P. P., Pierce, J. H., Kraus, M. H., Segatto, O., King, C. R., Aaronson, S. A., ErbB-2 is a potent oncogene when overexpressed in NIH73T3 cells (1987) Science, 237, pp. 178-182
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., McGuire, W. L., Human breast cancer: Correlation of relapse and survival with amplified HER-2/neu oncogene (1987) Science, 235, pp. 177-182
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Molina, M. A., Codony-Servat, J., Albanell, J., Rojo, F., Arribas, J., Baselga, J., Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells (2001) Cancer Res, 61, pp. 4744-4749
Hudis, C. A., Trastuzumab-mechanism of action and use in clinical practice (2007) N Engl J Med, 357, pp. 39-51
Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpress HER2 (2001) N Engl J Med, 344, pp. 783-792
Hellyer, N. J., Cheng, K., Koland, J. G., ErbB3 (HER3) interaction with the p85 regolatory subunit of phosphoinositide3-kinase (1988) Biochem J, 333, pp. 757-763
Sergina, N. V., Rausch, M., Wang, D., Blair, J., Hann, B., Shokat, K. M., Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3 (2007) Nature, 445, pp. 347-441
Hynes, N. E., Lane, H. A., ERBB receptors and cancer: The complexity of targeted inhibitors (2005) Nat Rev Cancer, 5, pp. 341-354
Siegel, P. M., Ryan, E. D., Cardiff, R. D., Muller, W. J., Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: Implications for human breast cancer (1999) EMBO J, 18, pp. 2149-2164
Cook, R. S., Garrett, R. T., Sanchez, V., Stanford, J. C., Young, C., Chakrabarty, A., ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis (2011) Cancer Res, 71, pp. 3941-3951
Engelman, J. A., Luo, J., Cantley, L. C., The evolution of phosphatidilinositol 3-kinase of growth and metabolism (2006) Nat Rev Cancer, 7, pp. 606-619
Saal, L. H., Holm, K., Maurer, M., Memeo, L., Su, T., Wang, X., PIK3CA mutations correlate with hormone receptor, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast cancer (2005) Cancer Res, 65, pp. 2554-2559
Zhu, S., Lee, D. A., Li, S., IL-12 and IL-27 sequential gene therapy via intramuscular electroporation delivery for eliminating distal aggressive tumors (2010) J Immunol, 184, pp. 2348-2354
Sanchez, C. G., Ma, C. X., Crowder, R. J., Guintoli, T., Phommaly, C., Gao, F., Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer (2011) Breast Cancer Res, 13, pp. R21
Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells
Cusanno F, Cisbani E, Colilli S, Fratoni R, Garibaldi F, Giuliani F, Gricia M, Lucentini M, Magliozzi ML, Santarivenere F, Torrioli S, Cinti MN, Pani R, Pellegrini R, Simonetti G, Schillaci O, Del Vecchio S, Salvatore M, Majewski S, De Vincentis G, Scopinaro F * Results of clinical trials with SPEM(278 views) Nucl Instrum Methods Phys Res Sect A, 2007 Feb 1; 497(1): 46-50. Impact Factor:3.221 ViewExport to BibTeXExport to EndNote