Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 8.535, 5-year impact factor: 8.419
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84876529807&partnerID=40&md5=940d1a0b5a9a34825d4386fa3e3fd078
Keywords: Delivery Systems, Folate Receptor, Gadolinium Complexes, Low Concentrations, Mri Contrast Agents, Relaxometric Properties, Short Incubations, Structural Behaviors, Doping (additives), Gadolinium Compounds, Monomers, Organic Acids, Nanostructures,
Affiliations:
*** IBB - CNR ***
CIRPeB, Department of Pharmacy, University of Naples Federico II, Via Mezzocannone, 16, 80134 Napoli, Italy
Department of Chemistry I.F.M., Molecular Imaging Centre, University of Turin, Via Nizza, 52, 10125 Turin, Italy
References:
Young, I.R., (2000) Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy, , John Wiley & Sons Ltd., Chicheste
Rinck, P.A., (2003) Magnetic Resonance in Medicine, , ABW Wissenschaftsverlag GmbH, Berlin
Li, J., Zheng, D., Bae, K.T., Woodard, P.K., Haacke, E.M., (1998) Invest. Radiol., 33, pp. 578-586
Mühler, A., (1998) Invest. Radiol., 33, pp. 709-714
Mühler, A., (1995) MAGMA, 3, pp. 21-33
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., (2008) Coord. Chem. Rev., 252, pp. 2424-2443
Mulder, W.J.M., Strijkers, G.J., Van Tilborg, G.A.F., Cormode, D.P., Fayad, Z.A., Nicolay, K., (2009) Acc. Chem. Res., 42, pp. 904-914
Accardo, A., Tesauro, D., Aloj, L., Pedone, C., Morelli, G., (2009) Coord. Chem. Rev., 253 (1718), pp. 2193-2213
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Texeira, J., Schillen, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Mulder, W.J.M., Van Der Schaft, D.W.J., Hautvast, P.A.I., Strijkers, G.J., Koning, G.A., Storm, G., Mayo, K.H., Nicolay, K., (2007) FASEB J, 21 (2), pp. 378-383
Brandwijk, R.J.M.G.E., Mulder, W.J.M., Nicolay, K., Mayo, K.H., Thijssen, V.L.J.L., Griffioen, A.W., (2007) Bioconjugate Chem., 18, pp. 785-790
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., (2007) ChemPhysChem, 8, pp. 2526-2538
Lipinski, M.J., Amirbekian, V., Frias, J.C., Aguinado, J.G.S., Mani, V., Briley-Saebo, K.C., Fuster, V., Fayad, Z.A., (2006) Magn. Reson. Med., 56 (3), pp. 601-610
Amirbekian, V., Lipinski, M.J., Briley-Saebo, K.C., Amirbekian, S., Aguinado, J.G.S., Weinreb, D.B., Vucic, E., Fayad, Z.A., (2007) Proc. Natl. Acad. Sci. U. S. A., 104 (3), pp. 961-966
Yaghmur, A., Glatter, O., (2009) Adv. Colloid Interface Sci., 147-148, pp. 333-342
Liu, G., Conn, C.E., Waddington, L.J., Mudie, S.T., Drummond, C.J., (2010) Langmuir, 26 (4), pp. 2383-2391
Conn, C.E., Panchagnula, V., Weerawardena, A., Waddington, L.J., Kennedy, D.F., Drummond, C.J., (2010) Langmuir, 26 (9), pp. 6240-6249
Moghaddam, M.J., De Campo, L., Waddington, L.J., Weerawardena, A., Kirby, N., Drummond, C.J., (2011) Soft Matter, 7, pp. 10994-11005
Accardo, A., Morisco, A., Gianolio, E., Tesauro, D., Mangiapia, G., Radulescu, A., Brandte, A., Morelli, G., (2011) J. Pept. Sci., 17, pp. 154-162
Schmitt, L., Dietrich, C., Tampe, R., (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Sharma, S.K., Lown, J.W., (2002) Tetrahedron Lett., 43, pp. 6665-6667
Dubochet, J., Adrian, M., Chang, J.J., Homo, J.C., Lepault, J., McDowall, A.W., Schultz, P., (1988) Q. Rev. Biophys., 21, pp. 129-228
Talmon, Y., (1996) Ber. Bunsenges. Phys. Chem., 100, pp. 364-372
Rank, A., Hauschild, S., Förster, S., Schubert, R., (2009) Langmuir, 25, pp. 1337-1344
Arena, F., Jebasingh, B.S., Gianolio, E., Stefania, R., Aime, S., (2011) Bioconjugate Chem., 22, pp. 2625-2635
Bradford, M.M., (1976) Anal. Biochem., 72, pp. 248-254
Gustafsson, J., Ljusberg-Wahren, H., Almgren, M., Larsson, K., (1997) Langmuir, 13, pp. 6964-6971
Spicer, P.T., Hayden, K.L., Lynch, M.L., Ofori-Boateng, A., Burns, J.L., (2001) Langmuir, 17 (13), pp. 5748-5756
Solomon, I., (1955) Phys. Rev., 99, pp. 559-565
Bloembergen, N., (1957) J. Chem. Phys., 27, pp. 572-573
Bloembergen, N., Morgan, L.O., (1961) J. Chem. Phys., 34, pp. 842-850
Aime, S., Botta, M., Fasano, M., Terreno, E., (2001) The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, p. 5. , ed. A. E. Merbach and E. Toth, John Wiley & Sons LTD
Bertini, I., Luchinat, C., (1996) Coord. Chem. Rev., 50, pp. 1-300
Kamaly, N., Kalber, T., Thanaou, M., Bell, D.J., Miller, A.D., (2009) Bioconjugate Chem., 20, pp. 648-655
Mangiapia, G., Vaccaro, M., D'Errico, G., Frielinghaus, H., Radulescu, A., Pipich, V., Carnerup, A.M., Paduano, L., (2011) Soft Matter, 7, pp. 10577-10580
Hilgenbrik, A.R., Low, P.S., (2005) J. Pharm. Sci., 94, pp. 2135-2142
Sega, E.I., Low, P.S., (2008) Cancer Metastasis Rev., 27, pp. 655-664
Kim, I.B., Shin, H., Garcia, A.L., Bunz, U.H.F., (2007) Bioconjugate Chem., 18, pp. 815-820
Choi, H., Choi, S.R., Zhou, R., Kung, H.F., Chen, I.W., (2004) Acad. Radiol., 11, pp. 996-1004
Ding, N., Lu, Y., Lee, R., Yang, C., Huang, L., Liu, J., Xiang, G., (2011) Int. J. Nanomed., 6, pp. 2513-2520
Low, P.S., Henne, W.A., Doorneweerd, D.D., (2008) Acc. Chem. Res., 41, pp. 120-129
Barauskas, J., Cervin, C., Jankunenc, M., Spandyreva, M., Ribokaite, K., Tiberg, F., Johnsson, M., (2010) Int. J. Pharm., 391, pp. 284-291
Murgia, S., Falchi, A.M., Mano, M., Lampis, S., Angius, R., Carnerup, A.M., Schmidt, J., Monduzzi, M., (2010) J. Phys. Chem. B, 114, pp. 3518-3525
Sahay, G., Batrakova, E.V., Kabanov, A.V., (2008) Bioconjugate Chem., 19, pp. 2023-2029
Li, X., Chen, D., Le, C., Zhu, C., Gang, Y., Hovgaard, L., Yang, M., (2011) Int. J. Nanomed., 6, pp. 3151-3162
Young, I. R., (2000) Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy, , John Wiley & Sons Ltd., Chicheste
Rinck, P. A., (2003) Magnetic Resonance in Medicine, , ABW Wissenschaftsverlag GmbH, Berlin
M hler, A., (1998) Invest. Radiol., 33, pp. 709-714
M hler, A., (1995) MAGMA, 3, pp. 21-33
Mulder, W. J. M., Strijkers, G. J., Van Tilborg, G. A. F., Cormode, D. P., Fayad, Z. A., Nicolay, K., (2009) Acc. Chem. Res., 42, pp. 904-914
Mulder, W. J. M., Van Der Schaft, D. W. J., Hautvast, P. A. I., Strijkers, G. J., Koning, G. A., Storm, G., Mayo, K. H., Nicolay, K., (2007) FASEB J, 21 (2), pp. 378-383
Brandwijk, R. J. M. G. E., Mulder, W. J. M., Nicolay, K., Mayo, K. H., Thijssen, V. L. J. L., Griffioen, A. W., (2007) Bioconjugate Chem., 18, pp. 785-790
Lipinski, M. J., Amirbekian, V., Frias, J. C., Aguinado, J. G. S., Mani, V., Briley-Saebo, K. C., Fuster, V., Fayad, Z. A., (2006) Magn. Reson. Med., 56 (3), pp. 601-610
Liu, G., Conn, C. E., Waddington, L. J., Mudie, S. T., Drummond, C. J., (2010) Langmuir, 26 (4), pp. 2383-2391
Conn, C. E., Panchagnula, V., Weerawardena, A., Waddington, L. J., Kennedy, D. F., Drummond, C. J., (2010) Langmuir, 26 (9), pp. 6240-6249
Moghaddam, M. J., De Campo, L., Waddington, L. J., Weerawardena, A., Kirby, N., Drummond, C. J., (2011) Soft Matter, 7, pp. 10994-11005
Sharma, S. K., Lown, J. W., (2002) Tetrahedron Lett., 43, pp. 6665-6667
Bradford, M. M., (1976) Anal. Biochem., 72, pp. 248-254
Spicer, P. T., Hayden, K. L., Lynch, M. L., Ofori-Boateng, A., Burns, J. L., (2001) Langmuir, 17 (13), pp. 5748-5756
Hilgenbrik, A. R., Low, P. S., (2005) J. Pharm. Sci., 94, pp. 2135-2142
Sega, E. I., Low, P. S., (2008) Cancer Metastasis Rev., 27, pp. 655-664
Kim, I. B., Shin, H., Garcia, A. L., Bunz, U. H. F., (2007) Bioconjugate Chem., 18, pp. 815-820
Choi, H., Choi, S. R., Zhou, R., Kung, H. F., Chen, I. W., (2004) Acad. Radiol., 11, pp. 996-1004
Low, P. S., Henne, W. A., Doorneweerd, D. D., (2008) Acc. Chem. Res., 41, pp. 120-129
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 8.535, 5-year impact factor: 8.419
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84876529807&partnerID=40&md5=940d1a0b5a9a34825d4386fa3e3fd078
Keywords: Delivery Systems, Folate Receptor, Gadolinium Complexes, Low Concentrations, Mri Contrast Agents, Relaxometric Properties, Short Incubations, Structural Behaviors, Doping (additives), Gadolinium Compounds, Monomers, Organic Acids, Nanostructures,
Affiliations:
*** IBB - CNR ***
CIRPeB, Department of Pharmacy, University of Naples Federico II, Via Mezzocannone, 16, 80134 Napoli, Italy
Department of Chemistry I.F.M., Molecular Imaging Centre, University of Turin, Via Nizza, 52, 10125 Turin, Italy
References:
Young, I.R., (2000) Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy, , John Wiley & Sons Ltd., Chicheste
Rinck, P.A., (2003) Magnetic Resonance in Medicine, , ABW Wissenschaftsverlag GmbH, Berlin
Li, J., Zheng, D., Bae, K.T., Woodard, P.K., Haacke, E.M., (1998) Invest. Radiol., 33, pp. 578-586
Mühler, A., (1998) Invest. Radiol., 33, pp. 709-714
Mühler, A., (1995) MAGMA, 3, pp. 21-33
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., (2008) Coord. Chem. Rev., 252, pp. 2424-2443
Mulder, W.J.M., Strijkers, G.J., Van Tilborg, G.A.F., Cormode, D.P., Fayad, Z.A., Nicolay, K., (2009) Acc. Chem. Res., 42, pp. 904-914
Accardo, A., Tesauro, D., Aloj, L., Pedone, C., Morelli, G., (2009) Coord. Chem. Rev., 253 (1718), pp. 2193-2213
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Texeira, J., Schillen, K., Aime, S., Morelli, G., (2007) ChemBioChem, 8, pp. 950-955
Mulder, W.J.M., Van Der Schaft, D.W.J., Hautvast, P.A.I., Strijkers, G.J., Koning, G.A., Storm, G., Mayo, K.H., Nicolay, K., (2007) FASEB J, 21 (2), pp. 378-383
Brandwijk, R.J.M.G.E., Mulder, W.J.M., Nicolay, K., Mayo, K.H., Thijssen, V.L.J.L., Griffioen, A.W., (2007) Bioconjugate Chem., 18, pp. 785-790
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., (2007) ChemPhysChem, 8, pp. 2526-2538
Lipinski, M.J., Amirbekian, V., Frias, J.C., Aguinado, J.G.S., Mani, V., Briley-Saebo, K.C., Fuster, V., Fayad, Z.A., (2006) Magn. Reson. Med., 56 (3), pp. 601-610
Amirbekian, V., Lipinski, M.J., Briley-Saebo, K.C., Amirbekian, S., Aguinado, J.G.S., Weinreb, D.B., Vucic, E., Fayad, Z.A., (2007) Proc. Natl. Acad. Sci. U. S. A., 104 (3), pp. 961-966
Yaghmur, A., Glatter, O., (2009) Adv. Colloid Interface Sci., 147-148, pp. 333-342
Liu, G., Conn, C.E., Waddington, L.J., Mudie, S.T., Drummond, C.J., (2010) Langmuir, 26 (4), pp. 2383-2391
Conn, C.E., Panchagnula, V., Weerawardena, A., Waddington, L.J., Kennedy, D.F., Drummond, C.J., (2010) Langmuir, 26 (9), pp. 6240-6249
Moghaddam, M.J., De Campo, L., Waddington, L.J., Weerawardena, A., Kirby, N., Drummond, C.J., (2011) Soft Matter, 7, pp. 10994-11005
Accardo, A., Morisco, A., Gianolio, E., Tesauro, D., Mangiapia, G., Radulescu, A., Brandte, A., Morelli, G., (2011) J. Pept. Sci., 17, pp. 154-162
Schmitt, L., Dietrich, C., Tampe, R., (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Sharma, S.K., Lown, J.W., (2002) Tetrahedron Lett., 43, pp. 6665-6667
Dubochet, J., Adrian, M., Chang, J.J., Homo, J.C., Lepault, J., McDowall, A.W., Schultz, P., (1988) Q. Rev. Biophys., 21, pp. 129-228
Talmon, Y., (1996) Ber. Bunsenges. Phys. Chem., 100, pp. 364-372
Rank, A., Hauschild, S., Förster, S., Schubert, R., (2009) Langmuir, 25, pp. 1337-1344
Arena, F., Jebasingh, B.S., Gianolio, E., Stefania, R., Aime, S., (2011) Bioconjugate Chem., 22, pp. 2625-2635
Bradford, M.M., (1976) Anal. Biochem., 72, pp. 248-254
Gustafsson, J., Ljusberg-Wahren, H., Almgren, M., Larsson, K., (1997) Langmuir, 13, pp. 6964-6971
Spicer, P.T., Hayden, K.L., Lynch, M.L., Ofori-Boateng, A., Burns, J.L., (2001) Langmuir, 17 (13), pp. 5748-5756
Solomon, I., (1955) Phys. Rev., 99, pp. 559-565
Bloembergen, N., (1957) J. Chem. Phys., 27, pp. 572-573
Bloembergen, N., Morgan, L.O., (1961) J. Chem. Phys., 34, pp. 842-850
Aime, S., Botta, M., Fasano, M., Terreno, E., (2001) The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, p. 5. , ed. A. E. Merbach and E. Toth, John Wiley & Sons LTD
Bertini, I., Luchinat, C., (1996) Coord. Chem. Rev., 50, pp. 1-300
Kamaly, N., Kalber, T., Thanaou, M., Bell, D.J., Miller, A.D., (2009) Bioconjugate Chem., 20, pp. 648-655
Mangiapia, G., Vaccaro, M., D'Errico, G., Frielinghaus, H., Radulescu, A., Pipich, V., Carnerup, A.M., Paduano, L., (2011) Soft Matter, 7, pp. 10577-10580
Hilgenbrik, A.R., Low, P.S., (2005) J. Pharm. Sci., 94, pp. 2135-2142
Sega, E.I., Low, P.S., (2008) Cancer Metastasis Rev., 27, pp. 655-664
Kim, I.B., Shin, H., Garcia, A.L., Bunz, U.H.F., (2007) Bioconjugate Chem., 18, pp. 815-820
Choi, H., Choi, S.R., Zhou, R., Kung, H.F., Chen, I.W., (2004) Acad. Radiol., 11, pp. 996-1004
Ding, N., Lu, Y., Lee, R., Yang, C., Huang, L., Liu, J., Xiang, G., (2011) Int. J. Nanomed., 6, pp. 2513-2520
Low, P.S., Henne, W.A., Doorneweerd, D.D., (2008) Acc. Chem. Res., 41, pp. 120-129
Barauskas, J., Cervin, C., Jankunenc, M., Spandyreva, M., Ribokaite, K., Tiberg, F., Johnsson, M., (2010) Int. J. Pharm., 391, pp. 284-291
Murgia, S., Falchi, A.M., Mano, M., Lampis, S., Angius, R., Carnerup, A.M., Schmidt, J., Monduzzi, M., (2010) J. Phys. Chem. B, 114, pp. 3518-3525
Sahay, G., Batrakova, E.V., Kabanov, A.V., (2008) Bioconjugate Chem., 19, pp. 2023-2029
Li, X., Chen, D., Le, C., Zhu, C., Gang, Y., Hovgaard, L., Yang, M., (2011) Int. J. Nanomed., 6, pp. 3151-3162
Young, I. R., (2000) Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy, , John Wiley & Sons Ltd., Chicheste
Rinck, P. A., (2003) Magnetic Resonance in Medicine, , ABW Wissenschaftsverlag GmbH, Berlin
M hler, A., (1998) Invest. Radiol., 33, pp. 709-714
M hler, A., (1995) MAGMA, 3, pp. 21-33
Mulder, W. J. M., Strijkers, G. J., Van Tilborg, G. A. F., Cormode, D. P., Fayad, Z. A., Nicolay, K., (2009) Acc. Chem. Res., 42, pp. 904-914
Mulder, W. J. M., Van Der Schaft, D. W. J., Hautvast, P. A. I., Strijkers, G. J., Koning, G. A., Storm, G., Mayo, K. H., Nicolay, K., (2007) FASEB J, 21 (2), pp. 378-383
Brandwijk, R. J. M. G. E., Mulder, W. J. M., Nicolay, K., Mayo, K. H., Thijssen, V. L. J. L., Griffioen, A. W., (2007) Bioconjugate Chem., 18, pp. 785-790
Lipinski, M. J., Amirbekian, V., Frias, J. C., Aguinado, J. G. S., Mani, V., Briley-Saebo, K. C., Fuster, V., Fayad, Z. A., (2006) Magn. Reson. Med., 56 (3), pp. 601-610
Liu, G., Conn, C. E., Waddington, L. J., Mudie, S. T., Drummond, C. J., (2010) Langmuir, 26 (4), pp. 2383-2391
Conn, C. E., Panchagnula, V., Weerawardena, A., Waddington, L. J., Kennedy, D. F., Drummond, C. J., (2010) Langmuir, 26 (9), pp. 6240-6249
Moghaddam, M. J., De Campo, L., Waddington, L. J., Weerawardena, A., Kirby, N., Drummond, C. J., (2011) Soft Matter, 7, pp. 10994-11005
Sharma, S. K., Lown, J. W., (2002) Tetrahedron Lett., 43, pp. 6665-6667
Bradford, M. M., (1976) Anal. Biochem., 72, pp. 248-254
Spicer, P. T., Hayden, K. L., Lynch, M. L., Ofori-Boateng, A., Burns, J. L., (2001) Langmuir, 17 (13), pp. 5748-5756
Hilgenbrik, A. R., Low, P. S., (2005) J. Pharm. Sci., 94, pp. 2135-2142
Sega, E. I., Low, P. S., (2008) Cancer Metastasis Rev., 27, pp. 655-664
Kim, I. B., Shin, H., Garcia, A. L., Bunz, U. H. F., (2007) Bioconjugate Chem., 18, pp. 815-820
Choi, H., Choi, S. R., Zhou, R., Kung, H. F., Chen, I. W., (2004) Acad. Radiol., 11, pp. 996-1004
Low, P. S., Henne, W. A., Doorneweerd, D. D., (2008) Acc. Chem. Res., 41, pp. 120-129
Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents
Highly ordered two or three dimensional mesophases in aqueous solution could be usefully obtained by using monoolein (MO) or diolein (DO) monomers. Nanostructures (also indicated as nanoparticles, NPs) of MO or DO containing different amounts (1%, 5%, 10% and 20%) of the synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd) have been prepared and characterized for their relaxometric and structural behaviors. The nanostructure is found in the 110-200 nm range for all investigated systems, while the presence of the gadolinium containing monomer produces a partial loss of the cubic symmetry, as shown by Cryo-TEM images of NPs doped with 10% w/w of (C18)2DTPA(Gd). Gadolinium containing nanostructures display high relaxivity values (in the 10-15 mM-1 s-1 range at 25° and 20 MHz, with a further increase at 37 °C for DO based NPs), and interesting relaxometric properties for their possible use as MRI contrast agents. NPs containing 10% w/w of (C18)2DTPA(Gd) (MO3-NPs and DO3-NPs) have been also derivatized by introducing 3% wt of (C18)2-Peg3000-FA to obtain targeted aggregates (MO3-NP-FA, DO3-NP-FA). A preferential uptake efficiency of DO3-NP-FA in IGROV-1 cells with respect to DO-NPs without folic acid is observed, especially when cells are incubated with low concentrations of nanostructures or at short incubation times, thus indicating its potential use as a target-selective delivery system for MRI contrast agents on tumor cells overexpressing the folate receptor. This journal is © The Royal Society of Chemistry 2013.
Highly ordered two or three dimensional mesophases in aqueous solution could be usefully obtained by using monoolein (MO) or diolein (DO) monomers. Nanostructures (also indicated as nanoparticles, NPs) of MO or DO containing different amounts (1%, 5%, 10% and 20%) of the synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd) have been prepared and characterized for their relaxometric and structural behaviors. The nanostructure is found in the 110-200 nm range for all investigated systems, while the presence of the gadolinium containing monomer produces a partial loss of the cubic symmetry, as shown by Cryo-TEM images of NPs doped with 10% w/w of (C18)2DTPA(Gd). Gadolinium containing nanostructures display high relaxivity values (in the 10-15 mM-1 s-1 range at 25° and 20 MHz, with a further increase at 37 °C for DO based NPs), and interesting relaxometric properties for their possible use as MRI contrast agents. NPs containing 10% w/w of (C18)2DTPA(Gd) (MO3-NPs and DO3-NPs) have been also derivatized by introducing 3% wt of (C18)2-Peg3000-FA to obtain targeted aggregates (MO3-NP-FA, DO3-NP-FA). A preferential uptake efficiency of DO3-NP-FA in IGROV-1 cells with respect to DO-NPs without folic acid is observed, especially when cells are incubated with low concentrations of nanostructures or at short incubation times, thus indicating its potential use as a target-selective delivery system for MRI contrast agents on tumor cells overexpressing the folate receptor. This journal is © The Royal Society of Chemistry 2013.
Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents
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Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents
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Impact Factor: 1.449
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
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Impact Factor: 5.476
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Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
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Impact Factor: 4.259
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Venuta A, Moret F, Dal Poggetto G, Esposito D, Fraix A, Avitabile C, Ungaro F, Malinconico M, Sortino S, Romanelli A, Laurienzo P, Reddi E, Quaglia F
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Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (317 views)
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Impact Factor: 7.469
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (291 views)
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Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (268 views) (PDF 207 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (446 views)
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Impact Factor: 4.521
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Calce E, Monfregola L, Saviano M, De Luca S
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Impact Factor: 3.455
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (451 views)
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Impact Factor: 1.951
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Cohen SS, Riven I, Cortajarena AL, De Rosa L, D'Andrea LD, Regan L, Haran G
* Probing the molecular origin of native-state flexibility in repeat proteins (352 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2015; 137(32): 10367-10373.
Impact Factor: 13.038
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (454 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
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Impact Factor: 4.906
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
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Impact Factor: 2.87
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
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Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
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Impact Factor: 3.415
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (528 views)
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Impact Factor: 4.869
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
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Impact Factor: 1.736
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Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (258 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (573 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (290 views)
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Impact Factor: 3.641
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (441 views)
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Impact Factor: 3.902
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (302 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
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Impact Factor: 3.834
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
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Impact Factor: 3.542
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
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* A snapshot of the vast array of diamagnetic CEST MRI contrast agents (6 views)
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Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
* A Novel Class of (1) H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by (14) N-Containing Imidazole Moieties (74 views)
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Tear LR, Carrera C, Gianolio E, Aime S
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Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (135 views)
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Impact Factor: 1.449
View Export to BibTeX Export to EndNote
Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (783 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
* Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe (297 views)
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Impact Factor: 4.259
View Export to BibTeX Export to EndNote
Venuta A, Moret F, Dal Poggetto G, Esposito D, Fraix A, Avitabile C, Ungaro F, Malinconico M, Sortino S, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Shedding light on surface exposition of poly(ethylene glycol) and folate targeting units on nanoparticles of poly(ε-caprolactone) diblock copolymers: Beyond a paradigm (549 views)
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Impact Factor: 0
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Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (317 views)
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
View Export to BibTeX Export to EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (291 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
View Export to BibTeX Export to EndNote
Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (268 views) (PDF 207 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
View Export to BibTeX Export to EndNote
Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (446 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
View Export to BibTeX Export to EndNote
Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (571 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
View Export to BibTeX Export to EndNote
Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (451 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
View Export to BibTeX Export to EndNote
Cohen SS, Riven I, Cortajarena AL, De Rosa L, D'Andrea LD, Regan L, Haran G
* Probing the molecular origin of native-state flexibility in repeat proteins (352 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2015; 137(32): 10367-10373.
Impact Factor: 13.038
View Export to BibTeX Export to EndNote
Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (454 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
View Export to BibTeX Export to EndNote
Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
View Export to BibTeX Export to EndNote
Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
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Impact Factor: 2.87
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (528 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (258 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (573 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (290 views)
J Chromatogr A (ISSN: 0021-9673, 0021-9673linking), 2007; 1155(2): 172-179.
Impact Factor: 3.641
View Export to BibTeX Export to EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (441 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (302 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
View Export to BibTeX Export to EndNote
Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (416 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (451 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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36 Records (33 excluding Abstracts).
Total impact factor: 141.737 (135.824 excluding Abstracts).
Total 5 year impact factor: 144.458 (137.829 excluding Abstracts).
Total impact factor: 141.737 (135.824 excluding Abstracts).
Total 5 year impact factor: 144.458 (137.829 excluding Abstracts).
412 views. Last view on Saturday 14 January 2023, 17:17:07
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