Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (853 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
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Paper type: Journal Article, Review,
Impact factor: 2.659, 5-year impact factor: 2.875
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865741390&partnerID=40&md5=c7b9926e5227d58c39c3435d44a0c0a1
Keywords: Brain Ischemia, Chronic Neurodegenerative Disorders, Metabotropic Glutamate Receptors, Neuroprotection, Neurotrophic Factors, 6 Tetrahydro 1 Methyl 4 Phenylpyridine, 2 Methyl 6 (phenylethynyl)pyridine, 3 [(2 Methyl 4 Thiazolyl)ethynyl]pyridine, 4 Amino 2 Oxabicyclo[3 1 0]hexane 4, 6 Dicarboxylic Acid, Brain Derived Neurotrophic Factor, Levodopa, Metabotropic Receptor, Metabotropic Receptor Antagonist, N Phenyl 7 (hydroxyimino)cyclopropa[b]chromen 1a Carboxamide, Nerve Growth Factor, Neurite Promoting Factor, Transforming Growth Factor Beta, Unclassified Drug, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Article, Brain Damage, Dopaminergic Nerve Cell, Dyskinesia, Excitotoxicity, Human, Intoxication, Learning Disorder, Nerve Cell Lesion, Nerve Cell Necrosis, Nerve Degeneration, Neurotoxicity, Nigroneostriatal System, Nonhuman, Parkinson Disease, Priority Journal, Striatonigral Degeneration, Stroke, Allosteric Regulation, Animals, Haplorhini, Neuroprotective Agents, Neuroprotective Agents Pharmacology, Metabotropic Glutamate Metabolism, 2 Methyl 6 (phenylethynyl) Pyridine, 3 [(2 Methyl 4 Thiazolyl) Ethynyl] Pyridine, 4 Amino 2 Oxabicyclo [3 1 0] Hexane 4, N Phenyl 7 (hydroxyimino) Cyclopropa [b] Chromen 1a Carboxamide,
Affiliations:
*** IBB - CNR ***
Department of Formative Processes, University of Catania, Catania, Italy
Department of Clinical and Molecular Biomedicine, Section of Pharmacology, University of Catania, Catania 95125, Italy
I.N.M. Neuromed, Località Camerelle, 86077 Pozzilli, Italy
Department of Drug Sciences, University of Catania, Catania, Italy
I.B.B., CNR-Catania, 95125 Catania, Italy
Department of Human Physiology and Pharmacology, University of Rome, Sapienza, Piazzale Aldo Moro, 5, 00185 Rome, Italy
I. N. M. Neuromed, Localit Camerelle, 86077 Pozzilli, Italy
I. B. B., CNR-Catania, 95125 Catania, Italy
References:
Not available.
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Review,
Impact factor: 2.659, 5-year impact factor: 2.875
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865741390&partnerID=40&md5=c7b9926e5227d58c39c3435d44a0c0a1
Keywords: Brain Ischemia, Chronic Neurodegenerative Disorders, Metabotropic Glutamate Receptors, Neuroprotection, Neurotrophic Factors, 6 Tetrahydro 1 Methyl 4 Phenylpyridine, 2 Methyl 6 (phenylethynyl)pyridine, 3 [(2 Methyl 4 Thiazolyl)ethynyl]pyridine, 4 Amino 2 Oxabicyclo[3 1 0]hexane 4, 6 Dicarboxylic Acid, Brain Derived Neurotrophic Factor, Levodopa, Metabotropic Receptor, Metabotropic Receptor Antagonist, N Phenyl 7 (hydroxyimino)cyclopropa[b]chromen 1a Carboxamide, Nerve Growth Factor, Neurite Promoting Factor, Transforming Growth Factor Beta, Unclassified Drug, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Article, Brain Damage, Dopaminergic Nerve Cell, Dyskinesia, Excitotoxicity, Human, Intoxication, Learning Disorder, Nerve Cell Lesion, Nerve Cell Necrosis, Nerve Degeneration, Neurotoxicity, Nigroneostriatal System, Nonhuman, Parkinson Disease, Priority Journal, Striatonigral Degeneration, Stroke, Allosteric Regulation, Animals, Haplorhini, Neuroprotective Agents, Neuroprotective Agents Pharmacology, Metabotropic Glutamate Metabolism, 2 Methyl 6 (phenylethynyl) Pyridine, 3 [(2 Methyl 4 Thiazolyl) Ethynyl] Pyridine, 4 Amino 2 Oxabicyclo [3 1 0] Hexane 4, N Phenyl 7 (hydroxyimino) Cyclopropa [b] Chromen 1a Carboxamide,
Affiliations:
*** IBB - CNR ***
Department of Formative Processes, University of Catania, Catania, Italy
Department of Clinical and Molecular Biomedicine, Section of Pharmacology, University of Catania, Catania 95125, Italy
I.N.M. Neuromed, Località Camerelle, 86077 Pozzilli, Italy
Department of Drug Sciences, University of Catania, Catania, Italy
I.B.B., CNR-Catania, 95125 Catania, Italy
Department of Human Physiology and Pharmacology, University of Rome, Sapienza, Piazzale Aldo Moro, 5, 00185 Rome, Italy
I. N. M. Neuromed, Localit Camerelle, 86077 Pozzilli, Italy
I. B. B., CNR-Catania, 95125 Catania, Italy
References:
Not available.
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?
Moving from early studies, we here review the most recent evidence linking metabotropic glutamate (mGlu) receptors to processes of neurodegeneration/ neuroprotection. The use of knockout mice and subtype-selective drugs has increased our knowledge of the precise role played by individual mGlu receptor subtypes in these processes. Activation of mGlu1 and mGlu5 receptors may either amplify or reduce neuronal damage depending on the context and the nature of the toxic insults. In contrast, mGlu1 and mGlu5 receptors antagonists are consistently protective in in vitro and in vivo models of neuronal death. A series of studies suggest that mGlu1 receptor antagonists or negative allosteric modulators (NAMs) are promising candidates for the treatment of ischemic brain damage, whereas mGlu5 receptor NAMs, which have been clinically developed for the treatment of Parkinson's disease (PD) and l-DOPA-induced dyskinesias, protect nigro-striatal dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) toxicity in mice and monkeys. Activation of glial mGlu3 receptors promotes the formation of various neurotrophic factors, such as transforming growth factor-β (TGF-β), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF). Hence, selective mGlu3 receptor agonists or positive allosteric modulators (PAMs) (not yet available) are potentially helpful in the treatment of chronic neurodegenerative disorders such as PD, Alzheimer's disease (AD), and amyotrophic lateral sclerosis. Selective mGlu2 receptor PAMs should be used with caution in AD patients because these drugs are shown to amplify β-amyloid neurotoxicity. Finally, mGlu4 receptor agonists/PAMs share with mGlu5 receptor NAMs the ability to improve motor symptoms associated with PD and attenuate nigro-striatal degeneration at the same time. No data are yet available on the role of mGlu7 and mGlu8 receptors in neurodegeneration/ neuroprotection. © 2012 Elsevier Ltd. All rights reserved.
Moving from early studies, we here review the most recent evidence linking metabotropic glutamate (mGlu) receptors to processes of neurodegeneration/ neuroprotection. The use of knockout mice and subtype-selective drugs has increased our knowledge of the precise role played by individual mGlu receptor subtypes in these processes. Activation of mGlu1 and mGlu5 receptors may either amplify or reduce neuronal damage depending on the context and the nature of the toxic insults. In contrast, mGlu1 and mGlu5 receptors antagonists are consistently protective in in vitro and in vivo models of neuronal death. A series of studies suggest that mGlu1 receptor antagonists or negative allosteric modulators (NAMs) are promising candidates for the treatment of ischemic brain damage, whereas mGlu5 receptor NAMs, which have been clinically developed for the treatment of Parkinson's disease (PD) and l-DOPA-induced dyskinesias, protect nigro-striatal dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) toxicity in mice and monkeys. Activation of glial mGlu3 receptors promotes the formation of various neurotrophic factors, such as transforming growth factor-β (TGF-β), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF). Hence, selective mGlu3 receptor agonists or positive allosteric modulators (PAMs) (not yet available) are potentially helpful in the treatment of chronic neurodegenerative disorders such as PD, Alzheimer's disease (AD), and amyotrophic lateral sclerosis. Selective mGlu2 receptor PAMs should be used with caution in AD patients because these drugs are shown to amplify β-amyloid neurotoxicity. Finally, mGlu4 receptor agonists/PAMs share with mGlu5 receptor NAMs the ability to improve motor symptoms associated with PD and attenuate nigro-striatal degeneration at the same time. No data are yet available on the role of mGlu7 and mGlu8 receptors in neurodegeneration/ neuroprotection. © 2012 Elsevier Ltd. All rights reserved.
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?
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Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?
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Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (408 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (638 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Sciacca MFM, Romanucci V, Zarrelli A, Monaco I, Lolicato F, Spinella N, Galati C, Grasso G, D'Urso L, Romeo M, Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C, Milardi D
* Inhibition of Abeta Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry (402 views) (PDF 195 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2017 Jun 09; N/D: N/D-N/D.
Impact Factor: 4.211
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Copani A
* The underexplored question of beta-amyloid monomers (299 views)
Eur J Pharmacol (ISSN: 0014-2999), 2017 May 31; N/D: N/D-N/D.
Impact Factor: 3.04
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (296 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (829 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
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Caraci F, Tascedda F, Merlo F, Benatti C, Spampinato S, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A
* Fluoxetine Prevents Ab1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth- Factor-b1 (291 views) (PDF 203 views)
Frontiers In Pharmacology, 2016 Oct; 7: 1-11.
Impact Factor: 4.418
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Pignataro G, Ziaco B, Tortiglione A, Gala R, Cuomo O, Vinciguerra A, Lapi D, Mastantuono T, Anzilotti S, D'Andrea LD, Pedone C, Di Renzo G, Annunziato L, Cataldi M
* Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion (287 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2015 Sep 16; 6(9): 1517-1525.
Impact Factor: 4.348
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (880 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E
* A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells (343 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic, 1948-7193linking), 2015; 6(8): 1379-1392.
Impact Factor: 4.348
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (623 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (528 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (5024 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (409 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1422 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (356 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (1050 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
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Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (547 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
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Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (478 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (772 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (456 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (692 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (668 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1314 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1722 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1465 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (501 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
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Gustavsson T, Banyasz A, Sarkar N, Markovitsi D, Improta R
* Statin: New life for an old drug (368 views)
Pharmacol Res Academic Press, 2008 Jun 23; 350(1-3): 1-2.
Impact Factor: 3.976
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (450 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (459 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1054 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (680 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Pappata S
* Tracking the dynamics of secondary degeneration after stroke (376 views)
J Neurol Neurosurg Psychiatry (ISSN: 0022-3050), 2007 Jun; 78(6): 554-554.
Impact Factor: 3.857
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (592 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (725 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (814 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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41 Records (39 excluding Abstracts).
Total impact factor: 199.539 (190.668 excluding Abstracts).
Total 5 year impact factor: 182.882 (173.69 excluding Abstracts).
Total impact factor: 199.539 (190.668 excluding Abstracts).
Total 5 year impact factor: 182.882 (173.69 excluding Abstracts).
853 views. Last view on Thursday 14 September 2023, 1:22:26
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