IL-32 Promotes Angiogenesis (830 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
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Paper type: Journal Article,
Impact factor: 4.922, 5-year impact factor: 5.264
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84892700407&partnerID=40&md5=a21cccfae6647aeac2ed898eb859caea
Keywords: Activin A, Endostatin, Gamma Interferon, Gelatinase B, Interleukin 32, Interleukin 32gamma, Lactate Dehydrogenase, Nitric Oxide, Protein Bak, Protein Bcl 2, Semaxanib, Small Interfering Rna, Transforming Growth Factor Beta, Unclassified Drug, Vasculotropin, Vasculotropin Receptor, Vitronectin Receptor, Adult, Animal Experiment, Animal Tissue, Apoptosis, Article, Cell Proliferation, Cellular Distribution, Coculture, Concentration Response, Controlled Study, Glioblastoma, Human, Human Cell, Human Tissue, Microvascular Endothelial Cell, Mouse, Neovascularization (pathology), Newborn, Nonhuman, Priority Journal, Pulmonary Hypertension, Umbilical Vein Endothelial Cell, Human Umbilical Vein Endothelial Cells, Integrin Alphavbeta3, Interferon-Gamma, Matrix Metalloproteinase 9, Nitrogen Oxides, Vascular Endothelial Growth Factor,
Affiliations:
*** IBB - CNR ***
Ritchie Centre, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3168, Australia
Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, United States
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerce, Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, 80134 Naples, Italy
Department of Pharmacy, University of Naples Federico II, 80134 Naples, Italy
ArisGen SA, 1228 Plan-les-Ouates, Switzerland
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, United States
Department of Medicine, University of Colorado Denver, Aurora, CO 80045, United States
Department of Pathology, University of Colorado Denver, Aurora, CO 80045, United States
Radboud University Medical Center, 6500 HB Nijmegen, Netherlands
Pulmonary and Critical Care Medicine Division, Molecular Medicine Research Building, Virginia Commonwealth University, Broad Street, Richmond, VA 23298, United States
References:
Kim, S.H., Han, S.Y., Azam, T., Yoon, D.Y., Dinarello, C.A., Interleukin-32: A cytokine and inducer of TNFa (2005) Immunity, 22, pp. 131-14
Goda, C., Kanaji, T., Kanaji, S., Tanaka, G., Arima, K., Ohno, S., Izuhara, K., Involvement of IL-32 in activation-induced cell death in T cells (2006) International Immunology, 18 (2), pp. 233-240. , DOI 10.1093/intimm/dxh339
Imaeda, H., Andoh, A., Aomatsu, T., Osaki, R., Bamba, S., Inatomi, O., Shimizu, T., Fujiyama, Y., A new isoform of interleukin-32 suppresses IL-8 mRNA expression in the intestinal epithelial cell line HT-29 (2011) Mol Med Rep, 4, pp. 483-487
Nold-Petry, C.A., Nold, M.F., Zepp, J.A., Kim, S.H., Voelkel, N.F., Dinarello, C.A., IL-32-dependent effects of IL-1β on endothelial cell functions (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 3883-3888
Heinhuis, B., Netea, M.G., Van Den-Berg, W.B., Dinarello, C.A., Joosten, L.A., Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death (2012) Cytokine, 60, pp. 321-327
Heinhuis, B., Koenders, M.I., Van De-Loo, F.A., Netea, M.G., Van Den-Berg, W.B., Joosten, L.A., Inflammation-dependent secretion and splicing of IL-32γ in rheumatoid arthritis (2011) Proc. Natl. Acad. Sci. USA, 108, pp. 4962-4967
Novick, D., Rubinstein, M., Azam, T., Rabinkov, A., Dinarello, C.A., Kim, S.-H., Proteinase 3 is an IL-32 binding protein (2006) Proceedings of the National Academy of Sciences of the United States of America, 103 (9), pp. 3316-3321. , DOI 10.1073/pnas.0511206103
Kim, S., Lee, S., Her, E., Bae, S., Choi, J., Hong, J., Jaekal, J., Kim, S., Proteinase 3-processed form of the recombinant IL-32 separate domain (2008) BMB Rep, 41, pp. 814-819
Nold, M.F., Nold-Petry, C.A., Pott, G.B., Zepp, J.A., Saavedra, M.T., Kim, S.H., Dinarello, C.A., Endogenous IL-32 controls cytokine and HIV-1 production (2008) J. Immunol., 181, pp. 557-565
Calabrese, F., Baraldo, S., Bazzan, E., Lunardi, F., Rea, F., Maestrelli, P., Turato, G., Zuin, R., IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease (2008) Am. J. Respir. Crit. Care Med., 178, pp. 894-901
Jeong, H.J., Shin, S.Y., Oh, H.A., Kim, M.H., Cho, J.S., Kim, H.M., IL-32 up-regulation is associated with inflammatory cytokine production in allergic rhinitis (2011) J. Pathol., 224, pp. 553-563
Na, S.J., So, S.H., Lee, K.O., Choi, Y.C., Elevated serum level of interleukin-32α in the patients with myasthenia gravis (2011) J. Neurol., 258, pp. 1865-1870
Cagnard, N., Letourneur, F., Essabbani, A., Devauchelle, V., Mistou, S., Rapinat, A., Decraene, C., Chiocchia, G., Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes (2005) European Cytokine Network, 16 (4), pp. 289-292
Joosten, L.A.B., Netea, M.G., Kim, S.-H., Yoon, D.-Y., Oppers-Walgreen, B., Radstake, T.R.D., Barrera, P., Van Den Berg, W.B., IL-32, a proinflammatory cytokine in rheumatoid arthritis (2006) Proceedings of the National Academy of Sciences of the United States of America, 103 (9), pp. 3298-3303. , DOI 10.1073/pnas.0511233103
Zepp, J.A., Nold-Petry, C.A., Dinarello, C.A., Nold, M.F., Protection from RNA and DNA viruses by IL-32 (2011) J. Immunol., 186, pp. 4110-4118
Li, W., Sun, W., Liu, L., Yang, F., Li, Y., Chen, Y., Fang, J., Zhu, Y., IL-32: A host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection (2010) J. Immunol., 185, pp. 5056-5065
Pan, X., Cao, H., Lu, J., Shu, X., Xiong, X., Hong, X., Xu, Q., Shen, G., Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-kB (2011) Mol. Immunol., 48, pp. 1573-1577
Moschen, A.R., Fritz, T., Clouston, A.D., Rebhan, I., Bauhofer, O., Barrie, H.D., Powell, E.E., Bartenschlager, R., Interleukin-32: A new proinflammatory cytokine involved in hepatitis C virusrelated liver inflammation and fibrosis (2011) Hepatology, 53, pp. 1819-1829
Lee, S., Kim, J.H., Kim, H., Kang, J.W., Kim, S.H., Yang, Y., Kim, J., Yoon, D.Y., Activation of the interleukin-32 proinflammatory pathway in response to human papillomavirus infection and overexpression of interleukin-32 controls the expression of the human papillomavirus oncogene (2011) Immunology, 132, pp. 410-420
Nishimoto, K.P., Laust, A.K., Nelson, E.L., A human dendritic cell subset receptive to the Venezuelan equine encephalitis virus-derived replicon particle constitutively expresses IL-32 (2008) J. Immunol., 181, pp. 4010-4018
Marcondes, A.M., Mhyre, A.J., Stirewalt, D.L., Kim, S.-H., Dinarello, C.A., Deeg, H.J., Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function (2008) Proceedings of the National Academy of Sciences of the United States of America, 105 (8), pp. 2865-2870. , http://www.pnas.org/cgi/reprint/105/8/2865, DOI 10.1073/pnas.0712391105
Nishida, A., Andoh, A., Inatomi, O., Fujiyama, Y., Interleukin-32 expression in the pancreas (2009) J. Biol. Chem., 284, pp. 17868-17876
Sorrentino, C., Di Carlo, E., Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype (2009) Am. J. Respir. Crit. Care Med., 180, pp. 769-779
Oh, J.H., Cho, M.C., Kim, J.H., Lee, S.Y., Kim, H.J., Park, E.S., Ban, J.O., Shim, J.H., IL-32γ inhibits cancer cell growth through inactivation of NF-kB and STAT3 signals (2011) Oncogene, 30, pp. 3345-3359
Ciccia, F., Alessandro, R., Rizzo, A., Principe, S., Raiata, F., Cavazza, A., Guggino, G., Ferrante, A., Expression of IL-32 in the inflamed arteries of patients with giant cell arteritis (2011) Arthritis Rheum., 63, pp. 2097-2104
Cool, C.D., Stewart, J.S., Werahera, P., Miller, G.J., Williams, R.L., Voelkel, N.F., Tuder, R.M., Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers: Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth (1999) American Journal of Pathology, 155 (2), pp. 411-419
Hassoun, P.M., Mouthon, L., Barberà, J.A., Eddahibi, S., Flores, S.C., Grimminger, F., Jones, P.L., Morrell, N.W., Inflammation, growth factors, and pulmonary vascular remodeling (2009) J. Am. Coll. Cardiol., 54 (1 SUPPL.), pp. S10-S19
Nicolls, M.R., Taraseviciene-Stewart, L., Rai, P.R., Badesch, D.B., Voelkel, N.F., Autoimmunity and pulmonary hypertension: A perspective (2005) European Respiratory Journal, 26 (6), pp. 1110-1118. , DOI 10.1183/09031936.05.00045705
Tuder, R.M., Groves, B., Badesch, D.B., Voelkel, N.F., Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension (1994) American Journal of Pathology, 144 (2), pp. 275-285
Humbert, M., Monti, G., Brenot, F., Sitbon, O., Portier, A., Grangeot-Keros, L., Duroux, P., Emilie, D., Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension (1995) Am. J. Respir. Crit. Care Med., 151, pp. 1628-1631
Tuder, R.M., Voelkel, N.F., Pulmonary hypertension and inflammation (1998) Journal of Laboratory and Clinical Medicine, 132 (1), pp. 16-24
Voelkel, N.F., Gomez-Arroyo, J.G., Abbate, A., Bogaard, H.J., Nicolls, M.R., Pathobiology of pulmonary arterial hypertension and right ventricular failure (2012) Eur. Respir. J., 40, pp. 1555-1565
Tuder, R.M., Chacon, M., Alger, L., Wang, J., Taraseviciene-Stewart, L., Kasahara, Y., Cool, C.D., Semenza, G.L., Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: Evidence for a process of disordered angiogenesis (2001) J. Pathol., 195, pp. 367-374
Canavese, M., Altruda, F., Ruzicka, T., Schauber, J., Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis: A possible target for novel therapies? (2010) J. Dermatol. Sci., 58, pp. 171-176
Hackeng, T.M., Fernandez, J.A., Dawson, P.E., Kent, S.B.H., Griffin, J.H., Chemical synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein S (2000) Proceedings of the National Academy of Sciences of the United States of America, 97 (26), pp. 14074-14078. , DOI 10.1073/pnas.260239797
Sakao, S., Taraseviciene-Stewart, L., Lee, J.D., Wood, K., Cool, C.D., Voelkel, N.F., Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells (2005) FASEB Journal, 19 (9), pp. 1178-1180. , DOI 10.1096/fj.04-3261fje
Humbert, M., Morrell, N.W., Archer, S.L., Stenmark, K.R., MacLean, M.R., Lang, I.M., Christman, B.W., Rabinovitch, M., Cellular and molecular pathobiology of pulmonary arterial hypertension (2004) Journal of the American College of Cardiology, 43 (12 SUPPL.), pp. 13S-24S. , DOI 10.1016/j.jacc.2004.02.029, PII S0735109704004383
Voronov, E., Shouval, D.S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C.A., Apte, R.N., IL-1 is required for tumor invasiveness and angiogenesis (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (5), pp. 2645-2650. , DOI 10.1073/pnas.0437939100
Carmi, Y., Voronov, E., Dotan, S., Lahat, N., Rahat, M.A., Fogel, M., Huszar, M., Apte, R.N., The role of macrophagederived IL-1 in induction and maintenance of angiogenesis (2009) J. Immunol., 183, pp. 4705-4714
Baumer, Y., Scholz, B., Ivanov, S., Schlosshauer, B., Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells (2011) Exp. Biol. Med. (Maywood), 236, pp. 692-700
Wang, W., Wang, Y.L., Chen, X.Y., Li, Y.T., Hao, W., Jin, Y.P., Han, B., Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension (2011) Mol. Biol. Rep., 38, pp. 3277-3284
Wort, S.J., Ito, M., Chou, P.C., Mc Master, S.K., Badiger, R., Jazrawi, E., De Souza, P., Pinhu, L., Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon γ is due to enhanced NF-kappaB binding and histone acetylation at specific kB sites (2009) J. Biol. Chem., 284, pp. 24297-24305
Lee, M.-S., Sarvetnick, N., Induction of vascular addressins and adhesion molecules in the pancreas of IFN-γ transgenic mice (1994) Journal of Immunology, 152 (9), pp. 4597-4603
Westphal, J.R., Willems, H.W., Tax, W.J.M., Koene, R.A.P., Ruiter, D.J., De Waal, R.M.W., The proliferative response of human T cells to allogeneic IFN-gamma-treated endothelial cells is mediated via both CD2/LFA-3 and LFA-1/ICAM-1 and -2 adhesion pathways (1993) Transplant Immunology, 1 (3), pp. 183-191
Farkas, L., Gauldie, J., Voelkel, N.F., Kolb, M., Pulmonary hypertension and idiopathic pulmonary fibrosis: A tale of angiogenesis, apoptosis and growth factors (2011) Am. J. Respir. Cell Mol. Biol., 45, pp. 1-15
Matsuo, Y., Sawai, H., Ochi, N., Yasuda, A., Takahashi, H., Funahashi, H., Takeyama, H., Guha, S., Interleukin-1alpha secreted by pancreatic cancer cells promotes angiogenesis and its therapeutic implications (2009) J. Surg. Res., 153, pp. 274-281
Shi, C.-S., Shi, G.-Y., Chang, Y.-S., Han, H.-S., Kuo, C.-H., Liu, C., Huang, H.-C., Wu, H.-L., Evidence of human thrombomodulin domain as a novel angiogenic factor (2005) Circulation, 111 (13), pp. 1627-1636. , DOI 10.1161/01.CIR.0000160364.05405.B5
Waugh, D.J., Wilson, C., The interleukin-8 pathway in cancer (2008) Clin. Cancer Res., 14, pp. 6735-6741
Rai, P.R., Cool, C.D., King, J.A., Stevens, T., Burns, N., Winn, R.A., Kasper, M., Voelkel, N.F., The cancer paradigm of severe pulmonary arterial hypertension (2008) Am. J. Respir. Crit. Care Med., 178, pp. 558-564
Soon, E., Holmes, A.M., Treacy, C.M., Doughty, N.J., Southgate, L., MacHado, R.D., Trembath, R.C., Nicklin, P., Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension (2010) Circulation, 122, pp. 920-927
Kempuraj, D., Conti, P., Vasiadi, M., Alysandratos, K.D., Tagen, M., Kalogeromitros, D., Kourelis, T., Theoharides, T.C., IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells (2010) Eur. J. Dermatol., 20, pp. 865-867
Kobayashi, H., Lin, P.C., Molecular characterization of IL-32 in human endothelial cells (2009) Cytokine, 46, pp. 351-358
Shchors, K., Shchors, E., Rostker, F., Lawlor, E.R., Brown-Swigart, L., Evan, G.I., The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1β (2006) Genes and Development, 20 (18), pp. 2527-2538. , http://www.genesdev.org/cgi/reprint/20/18/2527, DOI 10.1101/gad.1455706
Salven, P., Hattori, K., Heissig, B., Rafii, S., Interleukin-1α promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion (2002) FASEB J., 16, pp. 1471-1473
Nazarenko, I., Marhaba, R., Reich, E., Voronov, E., Vitacolonna, M., Hildebrand, D., Elter, E., Zoller, M., Tumorigenicity of IL-1α- and IL-1β-deficient fibrosarcoma cells (2008) Neoplasia, 10 (6), pp. 549-562. , http://www.neoplasia.com/pdf/manuscript/v10i06/neo08286.pdf, DOI 10.1593/neo.08286
Ruegg, C., Dormond, O., Foletti, A., Suppression of tumor angiogenesis through the inhibition of integrin function and signaling in endothelial cells: Which side to target? (2002) Endothelium: Journal of Endothelial Cell Research, 9 (3), pp. 151-160. , DOI 10.1080/10623320213635
Cabrita, M.A., Jones, L.M., Quizi, J.L., Sabourin, L.A., McKay, B.C., Addison, C.L., Focal adhesion kinase inhibitors are potent anti-angiogenic agents (2011) Mol. Oncol., 5, pp. 517-526
Shen, T.-L., Park, A.Y.-J., Alcaraz, A., Peng, X., Jang, I., Koni, P., Flavell, R.A., Guan, J.-L., Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis (2005) Journal of Cell Biology, 169 (6), pp. 941-952. , http://www.jcb.org/cgi/reprint/169/6/941.pdf, DOI 10.1083/jcb.200411155
Nisato, R.E., Tille, J.-C., Jonczyk, A., Goodman, S.L., Pepper, M.S., αvβ3 and αvβ5 integrin antagonists inhibit angiogenesis in vitro (2003) Angiogenesis, 6 (2), pp. 105-119. , DOI 10.1023/B:AGEN.0000011801.98187.f2
Al Husseini, A., Bagnato, G., Farkas, L., Gomez-Arroyo, J., Farkas, D., Mizuno, S., Kraskauskas, D., Bogaard, H.J., Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats (2012) Eur. Respir. J., 41, pp. 104-114
Moldenhauer, A., Futschik, M., Lu, H., Helmig, M., Götze, P., Bal, G., Zenke, M., Salama, A., Interleukin 32 promotes hematopoietic progenitor expansion and attenuates bone marrow cytotoxicity (2011) Eur. J. Immunol., 41, pp. 1774-1786
Kobayashi, H., Huang, J., Ye, F., Shyr, Y., Blackwell, T.S., Lin, P.C., Interleukin-32b propagates vascular inflammation and exacerbates sepsis in a mouse model (2010) PLoS ONE, 5, pp. e9458
Kobayashi, H., Yazlovitskaya, E.M., Lin, P.C., Interleukin-32 positively regulates radiation-induced vascular inflammation (2009) Int. J. Radiat. Oncol. Biol. Phys., 74, pp. 1573-1579
Cho, K.A., Jun, Y.H., Suh, J.W., Kang, J.S., Choi, H.J., Woo, S.Y., Orientia tsutsugamushi induced endothelial cell activation via the NOD1-IL-32 pathway (2010) Microb. Pathog., 49, pp. 95-104
Meyer, N., Christoph, J., Makrinioti, H., Indermitte, P., Rhyner, C., Soyka, M., Eiwegger, T., Fujita, H., Inhibition of angiogenesis by IL-32: Possible role in asthma (2012) J. Allergy Clin. Immunol., 129, pp. 964-973
Kim, S. H., Han, S. Y., Azam, T., Yoon, D. Y., Dinarello, C. A., Interleukin-32: A cytokine and inducer of TNFa (2005) Immunity, 22, pp. 131-14
Nold-Petry, C. A., Nold, M. F., Zepp, J. A., Kim, S. H., Voelkel, N. F., Dinarello, C. A., IL-32-dependent effects of IL-1 on endothelial cell functions (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 3883-3888
Nold, M. F., Nold-Petry, C. A., Pott, G. B., Zepp, J. A., Saavedra, M. T., Kim, S. H., Dinarello, C. A., Endogenous IL-32 controls cytokine and HIV-1 production (2008) J. Immunol., 181, pp. 557-565
Jeong, H. J., Shin, S. Y., Oh, H. A., Kim, M. H., Cho, J. S., Kim, H. M., IL-32 up-regulation is associated with inflammatory cytokine production in allergic rhinitis (2011) J. Pathol., 224, pp. 553-563
Na, S. J., So, S. H., Lee, K. O., Choi, Y. C., Elevated serum level of interleukin-32 in the patients with myasthenia gravis (2011) J. Neurol., 258, pp. 1865-1870
Joosten, L. A. B., Netea, M. G., Kim, S. -H., Yoon, D. -Y., Oppers-Walgreen, B., Radstake, T. R. D., Barrera, P., Van Den Berg, W. B., IL-32, a proinflammatory cytokine in rheumatoid arthritis (2006) Proceedings of the National Academy of Sciences of the United States of America, 103 (9), pp. 3298-3303. , DOI 10. 1073/pnas. 0511233103
Zepp, J. A., Nold-Petry, C. A., Dinarello, C. A., Nold, M. F., Protection from RNA and DNA viruses by IL-32 (2011) J. Immunol., 186, pp. 4110-4118
Moschen, A. R., Fritz, T., Clouston, A. D., Rebhan, I., Bauhofer, O., Barrie, H. D., Powell, E. E., Bartenschlager, R., Interleukin-32: A new proinflammatory cytokine involved in hepatitis C virusrelated liver inflammation and fibrosis (2011) Hepatology, 53, pp. 1819-1829
Lee, S., Kim, J. H., Kim, H., Kang, J. W., Kim, S. H., Yang, Y., Kim, J., Yoon, D. Y., Activation of the interleukin-32 proinflammatory pathway in response to human papillomavirus infection and overexpression of interleukin-32 controls the expression of the human papillomavirus oncogene (2011) Immunology, 132, pp. 410-420
Nishimoto, K. P., Laust, A. K., Nelson, E. L., A human dendritic cell subset receptive to the Venezuelan equine encephalitis virus-derived replicon particle constitutively expresses IL-32 (2008) J. Immunol., 181, pp. 4010-4018
Marcondes, A. M., Mhyre, A. J., Stirewalt, D. L., Kim, S. -H., Dinarello, C. A., Deeg, H. J., Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function (2008) Proceedings of the National Academy of Sciences of the United States of America, 105 (8), pp. 2865-2870. , http: //www. pnas. org/cgi/reprint/105/8/2865, DOI 10. 1073/pnas. 0712391105
Oh, J. H., Cho, M. C., Kim, J. H., Lee, S. Y., Kim, H. J., Park, E. S., Ban, J. O., Shim, J. H., IL-32 inhibits cancer cell growth through inactivation of NF-kB and STAT3 signals (2011) Oncogene, 30, pp. 3345-3359
Cool, C. D., Stewart, J. S., Werahera, P., Miller, G. J., Williams, R. L., Voelkel, N. F., Tuder, R. M., Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers: Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth (1999) American Journal of Pathology, 155 (2), pp. 411-419
Hassoun, P. M., Mouthon, L., Barber, J. A., Eddahibi, S., Flores, S. C., Grimminger, F., Jones, P. L., Morrell, N. W., Inflammation, growth factors, and pulmonary vascular remodeling (2009) J. Am. Coll. Cardiol., 54 (1 SUPPL.), pp. S10-S19
Nicolls, M. R., Taraseviciene-Stewart, L., Rai, P. R., Badesch, D. B., Voelkel, N. F., Autoimmunity and pulmonary hypertension: A perspective (2005) European Respiratory Journal, 26 (6), pp. 1110-1118. , DOI 10. 1183/09031936. 05. 00045705
Tuder, R. M., Groves, B., Badesch, D. B., Voelkel, N. F., Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension (1994) American Journal of Pathology, 144 (2), pp. 275-285
Tuder, R. M., Voelkel, N. F., Pulmonary hypertension and inflammation (1998) Journal of Laboratory and Clinical Medicine, 132 (1), pp. 16-24
Voelkel, N. F., Gomez-Arroyo, J. G., Abbate, A., Bogaard, H. J., Nicolls, M. R., Pathobiology of pulmonary arterial hypertension and right ventricular failure (2012) Eur. Respir. J., 40, pp. 1555-1565
Tuder, R. M., Chacon, M., Alger, L., Wang, J., Taraseviciene-Stewart, L., Kasahara, Y., Cool, C. D., Semenza, G. L., Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: Evidence for a process of disordered angiogenesis (2001) J. Pathol., 195, pp. 367-374
Hackeng, T. M., Fernandez, J. A., Dawson, P. E., Kent, S. B. H., Griffin, J. H., Chemical synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein S (2000) Proceedings of the National Academy of Sciences of the United States of America, 97 (26), pp. 14074-14078. , DOI 10. 1073/pnas. 260239797
Wang, W., Wang, Y. L., Chen, X. Y., Li, Y. T., Hao, W., Jin, Y. P., Han, B., Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension (2011) Mol. Biol. Rep., 38, pp. 3277-3284
Wort, S. J., Ito, M., Chou, P. C., Mc Master, S. K., Badiger, R., Jazrawi, E., De Souza, P., Pinhu, L., Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon is due to enhanced NF-kappaB binding and histone acetylation at specific kB sites (2009) J. Biol. Chem., 284, pp. 24297-24305
Lee, M. -S., Sarvetnick, N., Induction of vascular addressins and adhesion molecules in the pancreas of IFN- transgenic mice (1994) Journal of Immunology, 152 (9), pp. 4597-4603
Westphal, J. R., Willems, H. W., Tax, W. J. M., Koene, R. A. P., Ruiter, D. J., De Waal, R. M. W., The proliferative response of human T cells to allogeneic IFN-gamma-treated endothelial cells is mediated via both CD2/LFA-3 and LFA-1/ICAM-1 and -2 adhesion pathways (1993) Transplant Immunology, 1 (3), pp. 183-191
Shi, C. -S., Shi, G. -Y., Chang, Y. -S., Han, H. -S., Kuo, C. -H., Liu, C., Huang, H. -C., Wu, H. -L., Evidence of human thrombomodulin domain as a novel angiogenic factor (2005) Circulation, 111 (13), pp. 1627-1636. , DOI 10. 1161/01. CIR. 0000160364. 05405. B5
Waugh, D. J., Wilson, C., The interleukin-8 pathway in cancer (2008) Clin. Cancer Res., 14, pp. 6735-6741
Rai, P. R., Cool, C. D., King, J. A., Stevens, T., Burns, N., Winn, R. A., Kasper, M., Voelkel, N. F., The cancer paradigm of severe pulmonary arterial hypertension (2008) Am. J. Respir. Crit. Care Med., 178, pp. 558-564
Cabrita, M. A., Jones, L. M., Quizi, J. L., Sabourin, L. A., McKay, B. C., Addison, C. L., Focal adhesion kinase inhibitors are potent anti-angiogenic agents (2011) Mol. Oncol., 5, pp. 517-526
Shen, T. -L., Park, A. Y. -J., Alcaraz, A., Peng, X., Jang, I., Koni, P., Flavell, R. A., Guan, J. -L., Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis (2005) Journal of Cell Biology, 169 (6), pp. 941-952. , http: //www. jcb. org/cgi/reprint/169/6/941. pdf, DOI 10. 1083/jcb. 200411155
Nisato, R. E., Tille, J. -C., Jonczyk, A., Goodman, S. L., Pepper, M. S., v 3 and v 5 integrin antagonists inhibit angiogenesis in vitro (2003) Angiogenesis, 6 (2), pp. 105-119. , DOI 10. 1023/B: AGEN. 0000011801. 98187. f2
Cho, K. A., Jun, Y. H., Suh, J. W., Kang, J. S., Choi, H. J., Woo, S. Y., Orientia tsutsugamushi induced endothelial cell activation via the NOD1-IL-32 pathway (2010) Microb. Pathog., 49, pp. 95-104
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
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Paper type: Journal Article,
Impact factor: 4.922, 5-year impact factor: 5.264
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84892700407&partnerID=40&md5=a21cccfae6647aeac2ed898eb859caea
Keywords: Activin A, Endostatin, Gamma Interferon, Gelatinase B, Interleukin 32, Interleukin 32gamma, Lactate Dehydrogenase, Nitric Oxide, Protein Bak, Protein Bcl 2, Semaxanib, Small Interfering Rna, Transforming Growth Factor Beta, Unclassified Drug, Vasculotropin, Vasculotropin Receptor, Vitronectin Receptor, Adult, Animal Experiment, Animal Tissue, Apoptosis, Article, Cell Proliferation, Cellular Distribution, Coculture, Concentration Response, Controlled Study, Glioblastoma, Human, Human Cell, Human Tissue, Microvascular Endothelial Cell, Mouse, Neovascularization (pathology), Newborn, Nonhuman, Priority Journal, Pulmonary Hypertension, Umbilical Vein Endothelial Cell, Human Umbilical Vein Endothelial Cells, Integrin Alphavbeta3, Interferon-Gamma, Matrix Metalloproteinase 9, Nitrogen Oxides, Vascular Endothelial Growth Factor,
Affiliations:
*** IBB - CNR ***
Ritchie Centre, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3168, Australia
Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, United States
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerce, Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, 80134 Naples, Italy
Department of Pharmacy, University of Naples Federico II, 80134 Naples, Italy
ArisGen SA, 1228 Plan-les-Ouates, Switzerland
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, United States
Department of Medicine, University of Colorado Denver, Aurora, CO 80045, United States
Department of Pathology, University of Colorado Denver, Aurora, CO 80045, United States
Radboud University Medical Center, 6500 HB Nijmegen, Netherlands
Pulmonary and Critical Care Medicine Division, Molecular Medicine Research Building, Virginia Commonwealth University, Broad Street, Richmond, VA 23298, United States
References:
Kim, S.H., Han, S.Y., Azam, T., Yoon, D.Y., Dinarello, C.A., Interleukin-32: A cytokine and inducer of TNFa (2005) Immunity, 22, pp. 131-14
Goda, C., Kanaji, T., Kanaji, S., Tanaka, G., Arima, K., Ohno, S., Izuhara, K., Involvement of IL-32 in activation-induced cell death in T cells (2006) International Immunology, 18 (2), pp. 233-240. , DOI 10.1093/intimm/dxh339
Imaeda, H., Andoh, A., Aomatsu, T., Osaki, R., Bamba, S., Inatomi, O., Shimizu, T., Fujiyama, Y., A new isoform of interleukin-32 suppresses IL-8 mRNA expression in the intestinal epithelial cell line HT-29 (2011) Mol Med Rep, 4, pp. 483-487
Nold-Petry, C.A., Nold, M.F., Zepp, J.A., Kim, S.H., Voelkel, N.F., Dinarello, C.A., IL-32-dependent effects of IL-1β on endothelial cell functions (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 3883-3888
Heinhuis, B., Netea, M.G., Van Den-Berg, W.B., Dinarello, C.A., Joosten, L.A., Interleukin-32: A predominantly intracellular proinflammatory mediator that controls cell activation and cell death (2012) Cytokine, 60, pp. 321-327
Heinhuis, B., Koenders, M.I., Van De-Loo, F.A., Netea, M.G., Van Den-Berg, W.B., Joosten, L.A., Inflammation-dependent secretion and splicing of IL-32γ in rheumatoid arthritis (2011) Proc. Natl. Acad. Sci. USA, 108, pp. 4962-4967
Novick, D., Rubinstein, M., Azam, T., Rabinkov, A., Dinarello, C.A., Kim, S.-H., Proteinase 3 is an IL-32 binding protein (2006) Proceedings of the National Academy of Sciences of the United States of America, 103 (9), pp. 3316-3321. , DOI 10.1073/pnas.0511206103
Kim, S., Lee, S., Her, E., Bae, S., Choi, J., Hong, J., Jaekal, J., Kim, S., Proteinase 3-processed form of the recombinant IL-32 separate domain (2008) BMB Rep, 41, pp. 814-819
Nold, M.F., Nold-Petry, C.A., Pott, G.B., Zepp, J.A., Saavedra, M.T., Kim, S.H., Dinarello, C.A., Endogenous IL-32 controls cytokine and HIV-1 production (2008) J. Immunol., 181, pp. 557-565
Calabrese, F., Baraldo, S., Bazzan, E., Lunardi, F., Rea, F., Maestrelli, P., Turato, G., Zuin, R., IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease (2008) Am. J. Respir. Crit. Care Med., 178, pp. 894-901
Jeong, H.J., Shin, S.Y., Oh, H.A., Kim, M.H., Cho, J.S., Kim, H.M., IL-32 up-regulation is associated with inflammatory cytokine production in allergic rhinitis (2011) J. Pathol., 224, pp. 553-563
Na, S.J., So, S.H., Lee, K.O., Choi, Y.C., Elevated serum level of interleukin-32α in the patients with myasthenia gravis (2011) J. Neurol., 258, pp. 1865-1870
Cagnard, N., Letourneur, F., Essabbani, A., Devauchelle, V., Mistou, S., Rapinat, A., Decraene, C., Chiocchia, G., Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes (2005) European Cytokine Network, 16 (4), pp. 289-292
Joosten, L.A.B., Netea, M.G., Kim, S.-H., Yoon, D.-Y., Oppers-Walgreen, B., Radstake, T.R.D., Barrera, P., Van Den Berg, W.B., IL-32, a proinflammatory cytokine in rheumatoid arthritis (2006) Proceedings of the National Academy of Sciences of the United States of America, 103 (9), pp. 3298-3303. , DOI 10.1073/pnas.0511233103
Zepp, J.A., Nold-Petry, C.A., Dinarello, C.A., Nold, M.F., Protection from RNA and DNA viruses by IL-32 (2011) J. Immunol., 186, pp. 4110-4118
Li, W., Sun, W., Liu, L., Yang, F., Li, Y., Chen, Y., Fang, J., Zhu, Y., IL-32: A host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection (2010) J. Immunol., 185, pp. 5056-5065
Pan, X., Cao, H., Lu, J., Shu, X., Xiong, X., Hong, X., Xu, Q., Shen, G., Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-kB (2011) Mol. Immunol., 48, pp. 1573-1577
Moschen, A.R., Fritz, T., Clouston, A.D., Rebhan, I., Bauhofer, O., Barrie, H.D., Powell, E.E., Bartenschlager, R., Interleukin-32: A new proinflammatory cytokine involved in hepatitis C virusrelated liver inflammation and fibrosis (2011) Hepatology, 53, pp. 1819-1829
Lee, S., Kim, J.H., Kim, H., Kang, J.W., Kim, S.H., Yang, Y., Kim, J., Yoon, D.Y., Activation of the interleukin-32 proinflammatory pathway in response to human papillomavirus infection and overexpression of interleukin-32 controls the expression of the human papillomavirus oncogene (2011) Immunology, 132, pp. 410-420
Nishimoto, K.P., Laust, A.K., Nelson, E.L., A human dendritic cell subset receptive to the Venezuelan equine encephalitis virus-derived replicon particle constitutively expresses IL-32 (2008) J. Immunol., 181, pp. 4010-4018
Marcondes, A.M., Mhyre, A.J., Stirewalt, D.L., Kim, S.-H., Dinarello, C.A., Deeg, H.J., Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function (2008) Proceedings of the National Academy of Sciences of the United States of America, 105 (8), pp. 2865-2870. , http://www.pnas.org/cgi/reprint/105/8/2865, DOI 10.1073/pnas.0712391105
Nishida, A., Andoh, A., Inatomi, O., Fujiyama, Y., Interleukin-32 expression in the pancreas (2009) J. Biol. Chem., 284, pp. 17868-17876
Sorrentino, C., Di Carlo, E., Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype (2009) Am. J. Respir. Crit. Care Med., 180, pp. 769-779
Oh, J.H., Cho, M.C., Kim, J.H., Lee, S.Y., Kim, H.J., Park, E.S., Ban, J.O., Shim, J.H., IL-32γ inhibits cancer cell growth through inactivation of NF-kB and STAT3 signals (2011) Oncogene, 30, pp. 3345-3359
Ciccia, F., Alessandro, R., Rizzo, A., Principe, S., Raiata, F., Cavazza, A., Guggino, G., Ferrante, A., Expression of IL-32 in the inflamed arteries of patients with giant cell arteritis (2011) Arthritis Rheum., 63, pp. 2097-2104
Cool, C.D., Stewart, J.S., Werahera, P., Miller, G.J., Williams, R.L., Voelkel, N.F., Tuder, R.M., Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers: Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth (1999) American Journal of Pathology, 155 (2), pp. 411-419
Hassoun, P.M., Mouthon, L., Barberà, J.A., Eddahibi, S., Flores, S.C., Grimminger, F., Jones, P.L., Morrell, N.W., Inflammation, growth factors, and pulmonary vascular remodeling (2009) J. Am. Coll. Cardiol., 54 (1 SUPPL.), pp. S10-S19
Nicolls, M.R., Taraseviciene-Stewart, L., Rai, P.R., Badesch, D.B., Voelkel, N.F., Autoimmunity and pulmonary hypertension: A perspective (2005) European Respiratory Journal, 26 (6), pp. 1110-1118. , DOI 10.1183/09031936.05.00045705
Tuder, R.M., Groves, B., Badesch, D.B., Voelkel, N.F., Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension (1994) American Journal of Pathology, 144 (2), pp. 275-285
Humbert, M., Monti, G., Brenot, F., Sitbon, O., Portier, A., Grangeot-Keros, L., Duroux, P., Emilie, D., Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension (1995) Am. J. Respir. Crit. Care Med., 151, pp. 1628-1631
Tuder, R.M., Voelkel, N.F., Pulmonary hypertension and inflammation (1998) Journal of Laboratory and Clinical Medicine, 132 (1), pp. 16-24
Voelkel, N.F., Gomez-Arroyo, J.G., Abbate, A., Bogaard, H.J., Nicolls, M.R., Pathobiology of pulmonary arterial hypertension and right ventricular failure (2012) Eur. Respir. J., 40, pp. 1555-1565
Tuder, R.M., Chacon, M., Alger, L., Wang, J., Taraseviciene-Stewart, L., Kasahara, Y., Cool, C.D., Semenza, G.L., Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: Evidence for a process of disordered angiogenesis (2001) J. Pathol., 195, pp. 367-374
Canavese, M., Altruda, F., Ruzicka, T., Schauber, J., Vascular endothelial growth factor (VEGF) in the pathogenesis of psoriasis: A possible target for novel therapies? (2010) J. Dermatol. Sci., 58, pp. 171-176
Hackeng, T.M., Fernandez, J.A., Dawson, P.E., Kent, S.B.H., Griffin, J.H., Chemical synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein S (2000) Proceedings of the National Academy of Sciences of the United States of America, 97 (26), pp. 14074-14078. , DOI 10.1073/pnas.260239797
Sakao, S., Taraseviciene-Stewart, L., Lee, J.D., Wood, K., Cool, C.D., Voelkel, N.F., Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells (2005) FASEB Journal, 19 (9), pp. 1178-1180. , DOI 10.1096/fj.04-3261fje
Humbert, M., Morrell, N.W., Archer, S.L., Stenmark, K.R., MacLean, M.R., Lang, I.M., Christman, B.W., Rabinovitch, M., Cellular and molecular pathobiology of pulmonary arterial hypertension (2004) Journal of the American College of Cardiology, 43 (12 SUPPL.), pp. 13S-24S. , DOI 10.1016/j.jacc.2004.02.029, PII S0735109704004383
Voronov, E., Shouval, D.S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C.A., Apte, R.N., IL-1 is required for tumor invasiveness and angiogenesis (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (5), pp. 2645-2650. , DOI 10.1073/pnas.0437939100
Carmi, Y., Voronov, E., Dotan, S., Lahat, N., Rahat, M.A., Fogel, M., Huszar, M., Apte, R.N., The role of macrophagederived IL-1 in induction and maintenance of angiogenesis (2009) J. Immunol., 183, pp. 4705-4714
Baumer, Y., Scholz, B., Ivanov, S., Schlosshauer, B., Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells (2011) Exp. Biol. Med. (Maywood), 236, pp. 692-700
Wang, W., Wang, Y.L., Chen, X.Y., Li, Y.T., Hao, W., Jin, Y.P., Han, B., Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension (2011) Mol. Biol. Rep., 38, pp. 3277-3284
Wort, S.J., Ito, M., Chou, P.C., Mc Master, S.K., Badiger, R., Jazrawi, E., De Souza, P., Pinhu, L., Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon γ is due to enhanced NF-kappaB binding and histone acetylation at specific kB sites (2009) J. Biol. Chem., 284, pp. 24297-24305
Lee, M.-S., Sarvetnick, N., Induction of vascular addressins and adhesion molecules in the pancreas of IFN-γ transgenic mice (1994) Journal of Immunology, 152 (9), pp. 4597-4603
Westphal, J.R., Willems, H.W., Tax, W.J.M., Koene, R.A.P., Ruiter, D.J., De Waal, R.M.W., The proliferative response of human T cells to allogeneic IFN-gamma-treated endothelial cells is mediated via both CD2/LFA-3 and LFA-1/ICAM-1 and -2 adhesion pathways (1993) Transplant Immunology, 1 (3), pp. 183-191
Farkas, L., Gauldie, J., Voelkel, N.F., Kolb, M., Pulmonary hypertension and idiopathic pulmonary fibrosis: A tale of angiogenesis, apoptosis and growth factors (2011) Am. J. Respir. Cell Mol. Biol., 45, pp. 1-15
Matsuo, Y., Sawai, H., Ochi, N., Yasuda, A., Takahashi, H., Funahashi, H., Takeyama, H., Guha, S., Interleukin-1alpha secreted by pancreatic cancer cells promotes angiogenesis and its therapeutic implications (2009) J. Surg. Res., 153, pp. 274-281
Shi, C.-S., Shi, G.-Y., Chang, Y.-S., Han, H.-S., Kuo, C.-H., Liu, C., Huang, H.-C., Wu, H.-L., Evidence of human thrombomodulin domain as a novel angiogenic factor (2005) Circulation, 111 (13), pp. 1627-1636. , DOI 10.1161/01.CIR.0000160364.05405.B5
Waugh, D.J., Wilson, C., The interleukin-8 pathway in cancer (2008) Clin. Cancer Res., 14, pp. 6735-6741
Rai, P.R., Cool, C.D., King, J.A., Stevens, T., Burns, N., Winn, R.A., Kasper, M., Voelkel, N.F., The cancer paradigm of severe pulmonary arterial hypertension (2008) Am. J. Respir. Crit. Care Med., 178, pp. 558-564
Soon, E., Holmes, A.M., Treacy, C.M., Doughty, N.J., Southgate, L., MacHado, R.D., Trembath, R.C., Nicklin, P., Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension (2010) Circulation, 122, pp. 920-927
Kempuraj, D., Conti, P., Vasiadi, M., Alysandratos, K.D., Tagen, M., Kalogeromitros, D., Kourelis, T., Theoharides, T.C., IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells (2010) Eur. J. Dermatol., 20, pp. 865-867
Kobayashi, H., Lin, P.C., Molecular characterization of IL-32 in human endothelial cells (2009) Cytokine, 46, pp. 351-358
Shchors, K., Shchors, E., Rostker, F., Lawlor, E.R., Brown-Swigart, L., Evan, G.I., The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1β (2006) Genes and Development, 20 (18), pp. 2527-2538. , http://www.genesdev.org/cgi/reprint/20/18/2527, DOI 10.1101/gad.1455706
Salven, P., Hattori, K., Heissig, B., Rafii, S., Interleukin-1α promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion (2002) FASEB J., 16, pp. 1471-1473
Nazarenko, I., Marhaba, R., Reich, E., Voronov, E., Vitacolonna, M., Hildebrand, D., Elter, E., Zoller, M., Tumorigenicity of IL-1α- and IL-1β-deficient fibrosarcoma cells (2008) Neoplasia, 10 (6), pp. 549-562. , http://www.neoplasia.com/pdf/manuscript/v10i06/neo08286.pdf, DOI 10.1593/neo.08286
Ruegg, C., Dormond, O., Foletti, A., Suppression of tumor angiogenesis through the inhibition of integrin function and signaling in endothelial cells: Which side to target? (2002) Endothelium: Journal of Endothelial Cell Research, 9 (3), pp. 151-160. , DOI 10.1080/10623320213635
Cabrita, M.A., Jones, L.M., Quizi, J.L., Sabourin, L.A., McKay, B.C., Addison, C.L., Focal adhesion kinase inhibitors are potent anti-angiogenic agents (2011) Mol. Oncol., 5, pp. 517-526
Shen, T.-L., Park, A.Y.-J., Alcaraz, A., Peng, X., Jang, I., Koni, P., Flavell, R.A., Guan, J.-L., Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis (2005) Journal of Cell Biology, 169 (6), pp. 941-952. , http://www.jcb.org/cgi/reprint/169/6/941.pdf, DOI 10.1083/jcb.200411155
Nisato, R.E., Tille, J.-C., Jonczyk, A., Goodman, S.L., Pepper, M.S., αvβ3 and αvβ5 integrin antagonists inhibit angiogenesis in vitro (2003) Angiogenesis, 6 (2), pp. 105-119. , DOI 10.1023/B:AGEN.0000011801.98187.f2
Al Husseini, A., Bagnato, G., Farkas, L., Gomez-Arroyo, J., Farkas, D., Mizuno, S., Kraskauskas, D., Bogaard, H.J., Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats (2012) Eur. Respir. J., 41, pp. 104-114
Moldenhauer, A., Futschik, M., Lu, H., Helmig, M., Götze, P., Bal, G., Zenke, M., Salama, A., Interleukin 32 promotes hematopoietic progenitor expansion and attenuates bone marrow cytotoxicity (2011) Eur. J. Immunol., 41, pp. 1774-1786
Kobayashi, H., Huang, J., Ye, F., Shyr, Y., Blackwell, T.S., Lin, P.C., Interleukin-32b propagates vascular inflammation and exacerbates sepsis in a mouse model (2010) PLoS ONE, 5, pp. e9458
Kobayashi, H., Yazlovitskaya, E.M., Lin, P.C., Interleukin-32 positively regulates radiation-induced vascular inflammation (2009) Int. J. Radiat. Oncol. Biol. Phys., 74, pp. 1573-1579
Cho, K.A., Jun, Y.H., Suh, J.W., Kang, J.S., Choi, H.J., Woo, S.Y., Orientia tsutsugamushi induced endothelial cell activation via the NOD1-IL-32 pathway (2010) Microb. Pathog., 49, pp. 95-104
Meyer, N., Christoph, J., Makrinioti, H., Indermitte, P., Rhyner, C., Soyka, M., Eiwegger, T., Fujita, H., Inhibition of angiogenesis by IL-32: Possible role in asthma (2012) J. Allergy Clin. Immunol., 129, pp. 964-973
Kim, S. H., Han, S. Y., Azam, T., Yoon, D. Y., Dinarello, C. A., Interleukin-32: A cytokine and inducer of TNFa (2005) Immunity, 22, pp. 131-14
Nold-Petry, C. A., Nold, M. F., Zepp, J. A., Kim, S. H., Voelkel, N. F., Dinarello, C. A., IL-32-dependent effects of IL-1 on endothelial cell functions (2009) Proc. Natl. Acad. Sci. USA, 106, pp. 3883-3888
Nold, M. F., Nold-Petry, C. A., Pott, G. B., Zepp, J. A., Saavedra, M. T., Kim, S. H., Dinarello, C. A., Endogenous IL-32 controls cytokine and HIV-1 production (2008) J. Immunol., 181, pp. 557-565
Jeong, H. J., Shin, S. Y., Oh, H. A., Kim, M. H., Cho, J. S., Kim, H. M., IL-32 up-regulation is associated with inflammatory cytokine production in allergic rhinitis (2011) J. Pathol., 224, pp. 553-563
Na, S. J., So, S. H., Lee, K. O., Choi, Y. C., Elevated serum level of interleukin-32 in the patients with myasthenia gravis (2011) J. Neurol., 258, pp. 1865-1870
Joosten, L. A. B., Netea, M. G., Kim, S. -H., Yoon, D. -Y., Oppers-Walgreen, B., Radstake, T. R. D., Barrera, P., Van Den Berg, W. B., IL-32, a proinflammatory cytokine in rheumatoid arthritis (2006) Proceedings of the National Academy of Sciences of the United States of America, 103 (9), pp. 3298-3303. , DOI 10. 1073/pnas. 0511233103
Zepp, J. A., Nold-Petry, C. A., Dinarello, C. A., Nold, M. F., Protection from RNA and DNA viruses by IL-32 (2011) J. Immunol., 186, pp. 4110-4118
Moschen, A. R., Fritz, T., Clouston, A. D., Rebhan, I., Bauhofer, O., Barrie, H. D., Powell, E. E., Bartenschlager, R., Interleukin-32: A new proinflammatory cytokine involved in hepatitis C virusrelated liver inflammation and fibrosis (2011) Hepatology, 53, pp. 1819-1829
Lee, S., Kim, J. H., Kim, H., Kang, J. W., Kim, S. H., Yang, Y., Kim, J., Yoon, D. Y., Activation of the interleukin-32 proinflammatory pathway in response to human papillomavirus infection and overexpression of interleukin-32 controls the expression of the human papillomavirus oncogene (2011) Immunology, 132, pp. 410-420
Nishimoto, K. P., Laust, A. K., Nelson, E. L., A human dendritic cell subset receptive to the Venezuelan equine encephalitis virus-derived replicon particle constitutively expresses IL-32 (2008) J. Immunol., 181, pp. 4010-4018
Marcondes, A. M., Mhyre, A. J., Stirewalt, D. L., Kim, S. -H., Dinarello, C. A., Deeg, H. J., Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function (2008) Proceedings of the National Academy of Sciences of the United States of America, 105 (8), pp. 2865-2870. , http: //www. pnas. org/cgi/reprint/105/8/2865, DOI 10. 1073/pnas. 0712391105
Oh, J. H., Cho, M. C., Kim, J. H., Lee, S. Y., Kim, H. J., Park, E. S., Ban, J. O., Shim, J. H., IL-32 inhibits cancer cell growth through inactivation of NF-kB and STAT3 signals (2011) Oncogene, 30, pp. 3345-3359
Cool, C. D., Stewart, J. S., Werahera, P., Miller, G. J., Williams, R. L., Voelkel, N. F., Tuder, R. M., Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers: Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth (1999) American Journal of Pathology, 155 (2), pp. 411-419
Hassoun, P. M., Mouthon, L., Barber, J. A., Eddahibi, S., Flores, S. C., Grimminger, F., Jones, P. L., Morrell, N. W., Inflammation, growth factors, and pulmonary vascular remodeling (2009) J. Am. Coll. Cardiol., 54 (1 SUPPL.), pp. S10-S19
Nicolls, M. R., Taraseviciene-Stewart, L., Rai, P. R., Badesch, D. B., Voelkel, N. F., Autoimmunity and pulmonary hypertension: A perspective (2005) European Respiratory Journal, 26 (6), pp. 1110-1118. , DOI 10. 1183/09031936. 05. 00045705
Tuder, R. M., Groves, B., Badesch, D. B., Voelkel, N. F., Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension (1994) American Journal of Pathology, 144 (2), pp. 275-285
Tuder, R. M., Voelkel, N. F., Pulmonary hypertension and inflammation (1998) Journal of Laboratory and Clinical Medicine, 132 (1), pp. 16-24
Voelkel, N. F., Gomez-Arroyo, J. G., Abbate, A., Bogaard, H. J., Nicolls, M. R., Pathobiology of pulmonary arterial hypertension and right ventricular failure (2012) Eur. Respir. J., 40, pp. 1555-1565
Tuder, R. M., Chacon, M., Alger, L., Wang, J., Taraseviciene-Stewart, L., Kasahara, Y., Cool, C. D., Semenza, G. L., Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: Evidence for a process of disordered angiogenesis (2001) J. Pathol., 195, pp. 367-374
Hackeng, T. M., Fernandez, J. A., Dawson, P. E., Kent, S. B. H., Griffin, J. H., Chemical synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein S (2000) Proceedings of the National Academy of Sciences of the United States of America, 97 (26), pp. 14074-14078. , DOI 10. 1073/pnas. 260239797
Wang, W., Wang, Y. L., Chen, X. Y., Li, Y. T., Hao, W., Jin, Y. P., Han, B., Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension (2011) Mol. Biol. Rep., 38, pp. 3277-3284
Wort, S. J., Ito, M., Chou, P. C., Mc Master, S. K., Badiger, R., Jazrawi, E., De Souza, P., Pinhu, L., Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon is due to enhanced NF-kappaB binding and histone acetylation at specific kB sites (2009) J. Biol. Chem., 284, pp. 24297-24305
Lee, M. -S., Sarvetnick, N., Induction of vascular addressins and adhesion molecules in the pancreas of IFN- transgenic mice (1994) Journal of Immunology, 152 (9), pp. 4597-4603
Westphal, J. R., Willems, H. W., Tax, W. J. M., Koene, R. A. P., Ruiter, D. J., De Waal, R. M. W., The proliferative response of human T cells to allogeneic IFN-gamma-treated endothelial cells is mediated via both CD2/LFA-3 and LFA-1/ICAM-1 and -2 adhesion pathways (1993) Transplant Immunology, 1 (3), pp. 183-191
Shi, C. -S., Shi, G. -Y., Chang, Y. -S., Han, H. -S., Kuo, C. -H., Liu, C., Huang, H. -C., Wu, H. -L., Evidence of human thrombomodulin domain as a novel angiogenic factor (2005) Circulation, 111 (13), pp. 1627-1636. , DOI 10. 1161/01. CIR. 0000160364. 05405. B5
Waugh, D. J., Wilson, C., The interleukin-8 pathway in cancer (2008) Clin. Cancer Res., 14, pp. 6735-6741
Rai, P. R., Cool, C. D., King, J. A., Stevens, T., Burns, N., Winn, R. A., Kasper, M., Voelkel, N. F., The cancer paradigm of severe pulmonary arterial hypertension (2008) Am. J. Respir. Crit. Care Med., 178, pp. 558-564
Cabrita, M. A., Jones, L. M., Quizi, J. L., Sabourin, L. A., McKay, B. C., Addison, C. L., Focal adhesion kinase inhibitors are potent anti-angiogenic agents (2011) Mol. Oncol., 5, pp. 517-526
Shen, T. -L., Park, A. Y. -J., Alcaraz, A., Peng, X., Jang, I., Koni, P., Flavell, R. A., Guan, J. -L., Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis (2005) Journal of Cell Biology, 169 (6), pp. 941-952. , http: //www. jcb. org/cgi/reprint/169/6/941. pdf, DOI 10. 1083/jcb. 200411155
Nisato, R. E., Tille, J. -C., Jonczyk, A., Goodman, S. L., Pepper, M. S., v 3 and v 5 integrin antagonists inhibit angiogenesis in vitro (2003) Angiogenesis, 6 (2), pp. 105-119. , DOI 10. 1023/B: AGEN. 0000011801. 98187. f2
Cho, K. A., Jun, Y. H., Suh, J. W., Kang, J. S., Choi, H. J., Woo, S. Y., Orientia tsutsugamushi induced endothelial cell activation via the NOD1-IL-32 pathway (2010) Microb. Pathog., 49, pp. 95-104
IL-32 Promotes Angiogenesis
IL-32 is a multifaceted cytokine with a role in infections, autoimmune diseases, and cancer, and it exerts diverse functions, including aggravation of inflammation and inhibition of virus propagation. We previously identified IL-32 as a critical regulator of endothelial cell (EC) functions, and we now reveal that IL-32 also possesses angiogenic properties. The hyperproliferative ECs of human pulmonary arterial hypertension and glioblastoma multiforme exhibited a markedly increased abundance of IL-32, and, significantly, the cytokine colocalized with integrin alpha v beta(3). Vascular endothelial growth factor (VEGF) receptor blockade, which resulted in EC hyperproliferation, increased IL-32 three-fold. Small interfering RNA-mediated silencing of IL-32 negated the 58% proliferation of ECs that occurred within 24 h in scrambled-transfected controls. Reduction of IL-32 neither affected apoptosis (insignificant changes in Bak-1, Bcl-2, Bcl-x(L), lactate dehydrogenase, annexin V, and propidium iodide) nor VEGF or TGF-beta levels, but siIL-32-transfected adult and neonatal ECs produced up to 61% less NO, IL-8, and matrix metalloproteinase-9, and up to 3-fold more activin A and endostatin. In coculture-based angiogenesis assays, IL-32 gamma dose-dependently increased tube formation up to 3-fold; an alpha v beta(3) inhibitor prevented this activity and reduced IL-32 gamma-induced IL-8 by 85%. In matrigel plugs loaded with IL-32 gamma, VEGF, or vehicle and injected into live mice, we observed the anticipated VEGF-induced increase in neocapillarization (8-fold versus vehicle), but unexpectedly, IL-32 gamma was equally angiogenic. A second signal such as IFN-gamma was required to render cells responsive to exogenous IL-32 gamma; importantly, this was confirmed using a completely synthetic preparation of IL-32 gamma. In summary, we add angiogenic properties that are mediated by integrin alpha v beta(3) but VEGF-independent to the portfolio of IL-32, implicating a role for this versatile cytokine in pulmonary arterial hypertension and neoplastic diseases.
IL-32 is a multifaceted cytokine with a role in infections, autoimmune diseases, and cancer, and it exerts diverse functions, including aggravation of inflammation and inhibition of virus propagation. We previously identified IL-32 as a critical regulator of endothelial cell (EC) functions, and we now reveal that IL-32 also possesses angiogenic properties. The hyperproliferative ECs of human pulmonary arterial hypertension and glioblastoma multiforme exhibited a markedly increased abundance of IL-32, and, significantly, the cytokine colocalized with integrin alpha v beta(3). Vascular endothelial growth factor (VEGF) receptor blockade, which resulted in EC hyperproliferation, increased IL-32 three-fold. Small interfering RNA-mediated silencing of IL-32 negated the 58% proliferation of ECs that occurred within 24 h in scrambled-transfected controls. Reduction of IL-32 neither affected apoptosis (insignificant changes in Bak-1, Bcl-2, Bcl-x(L), lactate dehydrogenase, annexin V, and propidium iodide) nor VEGF or TGF-beta levels, but siIL-32-transfected adult and neonatal ECs produced up to 61% less NO, IL-8, and matrix metalloproteinase-9, and up to 3-fold more activin A and endostatin. In coculture-based angiogenesis assays, IL-32 gamma dose-dependently increased tube formation up to 3-fold; an alpha v beta(3) inhibitor prevented this activity and reduced IL-32 gamma-induced IL-8 by 85%. In matrigel plugs loaded with IL-32 gamma, VEGF, or vehicle and injected into live mice, we observed the anticipated VEGF-induced increase in neocapillarization (8-fold versus vehicle), but unexpectedly, IL-32 gamma was equally angiogenic. A second signal such as IFN-gamma was required to render cells responsive to exogenous IL-32 gamma; importantly, this was confirmed using a completely synthetic preparation of IL-32 gamma. In summary, we add angiogenic properties that are mediated by integrin alpha v beta(3) but VEGF-independent to the portfolio of IL-32, implicating a role for this versatile cytokine in pulmonary arterial hypertension and neoplastic diseases.
IL-32 Promotes Angiogenesis
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IL-32 Promotes Angiogenesis
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Colucci-D'Amato L, Cicatiello AE, Reccia MG, Volpicelli F, Severino V, Russo R, Sandomenico A, Doti N, D'Esposito V, Formisano P, Chambery A
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* A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells (588 views)
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Impact Factor: 4.079
View Export to BibTeX Export to EndNote
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Impact Factor: 4.518
View Export to BibTeX Export to EndNote
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Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Doti N, Scognamiglio PL, Madonna S, Scarponi C, Ruvo M, Perretta G, Albanesi C, Marasco D
* New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (1184 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Impact Factor: 4.779
View Export to BibTeX Export to EndNote
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* Artificial DNA and surface plasmon resonance (536 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
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Impact Factor: 2.608
View Export to BibTeX Export to EndNote
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Impact Factor: 3.871
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Impact Factor: 0.481
View Export to BibTeX Export to EndNote
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Impact Factor: 5.236
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* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
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Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
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* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (570 views)
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Impact Factor: 6.696
View Export to BibTeX Export to EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
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Impact Factor: 5.082
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13 Records (12 excluding Abstracts).
Total impact factor: 45.356 (45.356 excluding Abstracts).
Total 5 year impact factor: 45.463 (45.463 excluding Abstracts).
Total impact factor: 45.356 (45.356 excluding Abstracts).
Total 5 year impact factor: 45.463 (45.463 excluding Abstracts).
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