Role of tertiary structures on the Root effect in fish hemoglobins (544 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(9): 1885-1893.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.191, 5-year impact factor: 3.282
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84884606189&partnerID=40&md5=b53a4d0e0a3c47ea09f0428a3292a62d
Keywords: Hemoglobin, Microspectrophotometry, Oxygen Binding, Root Effect, X-Ray Crystallography, Deoxyhemoglobin, Proton, Allosterism, Article, Binding Affinity, Circular Dichroism, Conformational Transition, Crystal Structure, Ion Exchange Chromatography, Nonhuman, Priority Journal, Protein Tertiary Structure, X Ray Crystallography, Animal, Antarctica, Binding Site, Chemical Structure, Chemistry, Metabolism, Mammalia, Trematomus Bernacchii, Allosteric Regulation, Antarctic Regions, Fishes, Hydrogen-Ion Concentration, Models, Molecular, Protein Structure,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Parma, Parco Area delle Scienze 23/A, 43124 Parma, Italy
Department of Chemical Sciences, University of Naples Federico II, Via Cintia, I-80126, Naples, Italy
Institute of Biostructures and Bioimages, CNR, Naples, Via Mezzocannone 16, 80124, Naples, Italy
Department of Neurosciences, University of Parma, Parco Area delle Scienze 23/A, 43124 Parma, Italy
National Institute of Biostructures and Biosystems, Viale Medaglie d'Oro, 305, 00136 Rome, Italy
Institute of Protein Biochemistry, CNR, Via Pietro Castellino, 111, I-80131 Naples, Italy
References:
Bonaventura, C., Crumbliss, A.L., Weber, R.E., New insights into the proton-dependent oxygen affinity of Root effect haemoglobins (2004) Acta Physiologica Scandinavica, 182 (3), pp. 245-258. , DOI 10.1111/j.1365-201X.2004.01359.
Brittain, T., Root effect hemoglobins (2005) Journal of Inorganic Biochemistry, 99 (1), pp. 120-129. , DOI 10.1016/j.jinorgbio.2004.09.025, PII S0162013404002922, Heme-Diatomic Interactions, Part 1
Verde, C., Vergara, A., Mazzarella, L., Di Prisco, G., The hemoglobins of fishes living at polar latitudes - Current knowledge on structural adaptations in a changing environment (2008) Curr. Protein Pept. Sci., 9, pp. 578-590
Monod, J., Wyman, J., Changeux, J.P., On the nature of allosteric transitions: A plausible model (1965) J. Mol. Biol., 12, pp. 88-118
Edelstein, S.J., An allosteric theory for hemoglobin incorporating asymmetric states to test the putative molecular code for cooperativity (1996) Journal of Molecular Biology, 257 (4), pp. 737-744. , DOI 10.1006/jmbi.1996.0198
Eaton, W.A., Henry, E.R., Hofrichter, J., Bettati, S., Viappiani, C., Mozzarelli, A., Evolution of allosteric models for hemoglobin (2007) IUBMB Life, 59 (8-9), pp. 586-599. , DOI 10.1080/15216540701272380, PII 778359268, IUBMB Life Dedicated to Maurizio Brunori in the Occasion of his 70th Birthday
Henry, E.R., Bettati, S., Hofrichter, J., Eaton, W.A., A tertiary two-state allosteric model for hemoglobin (2002) Biophysical Chemistry, 98 (1-2), pp. 149-164. , DOI 10.1016/S0301-4622(02)00091-1, PII S0301462202000911
Viappiani, C., Bettati, S., Bruno, S., Ronda, L., Abbruzzetti, S., Mozzarelli, A., Eaton, W.A., New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels (2004) Proceedings of the National Academy of Sciences of the United States of America, 101 (40), pp. 14414-14419. , DOI 10.1073/pnas.0405987101
Tsuneshige, A., Park, S., Yonetani, T., Heterotropic effectors control the hemoglobin function by interacting with its T and R states - A new view on the principle of allostery (2002) Biophysical Chemistry, 98 (1-2), pp. 49-63. , DOI 10.1016/S0301-4622(02)00084-4, PII S0301462202000844
Bettati, S., Kwiatkowski, L.D., Kavanaugh, J.S., Mozzarelli, A., Arnone, A., Rossi, G.L., Noble, R.W., Structure and oxygen affinity of crystalline des-His-146β human hemoglobin in the T state (1997) Journal of Biological Chemistry, 272 (52), pp. 33077-33084. , DOI 10.1074/jbc.272.52.33077
Bettati, S., Mozzarelli, A., Perutz, M.F., Allosteric mechanism of haemoglobin: Rupture of salt-bridges raises the oxygen affinity of the T-structure (1998) Journal of Molecular Biology, 281 (4), pp. 581-585. , DOI 10.1006/jmbi.1998.1983
Mozzarelli, A., Bettati, S., Rivetti, C., Rossi, G.L., Colotti, G., Chiancone, E., Cooperative oxygen binding to Scapharca inaequivalvis hemoglobin in the crystal (1996) Journal of Biological Chemistry, 271 (7), pp. 3627-3632. , DOI 10.1074/jbc.271.7.3627
Mozzarelli, A., Rivetti, C., Rossi, G.L., Eaton, W.A., Henry, E.R., Allosteric effectors do not alter the oxygen affinity of hemoglobin crystals (1997) Protein Science, 6 (2), pp. 484-489
Mozzarelli, A., Rossi, G.L., Protein function in the crystal (1996) Annual Review of Biophysics and Biomolecular Structure, 25, pp. 343-365
Bruno, S., Bonaccio, M., Bettati, S., Rivetti, C., Viappiani, C., Abbruzzetti, S., Mozzarelli, A., High and low oxygen affinity conformations of T state hemoglobin (2001) Protein Science, 10 (11), pp. 2401-2407. , DOI 10.1110/ps.20501
Ronda, L., Bruno, S., Viappiani, C., Abbruzzetti, S., Mozzarelli, A., Lowe, K.C., Bettati, S., Circular dichroism spectroscopy of tertiary and quaternary conformations of human hemoglobin entrapped in wet silica gels (2006) Protein Science, 15 (8), pp. 1961-1967. , http://www.proteinscience.org/cgi/reprint/15/8/1961, DOI 10.1110/ps.062272306
Tame, J.R.H., Wilson, J.C., Weber, R.E., The crystal structures of trout Hb I in the deoxy and carbonmonoxy forms (1996) Journal of Molecular Biology, 259 (4), pp. 749-760. , DOI 10.1006/jmbi.1996.0355
Mylvaganam, S.E., Bonaventura, C., Bonaventura, J., Getzoff, E.D., Structural basis for the root effect in haemoglobin (1996) Nature Structural Biology, 3 (3), pp. 275-283. , DOI 10.1038/nsb0396-275
Yokoyama, T., Chong, K.T., Miyazaki, G., Morimoto, H., Shih, D.T.-B., Unzai, S., Tame, J.R.H., Park, S.-Y., Novel mechanisms of pH sensitivity in tuna hemoglobin. A structural explanation of the root effect (2004) Journal of Biological Chemistry, 279 (27), pp. 28632-28640. , DOI 10.1074/jbc.M401740200
Mazzarella, L., Bonomi, G., Lubrano, M.C., Merlino, A., Riccio, A., Vergara, A., Vitagliano, L., Di Prisco, G., Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (2006) Proteins: Structure, Function and Genetics, 62 (2), pp. 316-321. , DOI 10.1002/prot.20709
Mazzarella, L., Vergara, A., Vitagliano, L., Merlino, A., Bonomi, G., Scala, S., Verde, C., Di Prisco, G., High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (2006) Proteins: Structure, Function and Genetics, 65 (2), pp. 490-498. , DOI 10.1002/prot.21114
Coppola, D., Abbruzzetti, S., Nicoletti, F., Merlino, A., Gambacurta, A., Giordano, D., Howes, B.D., Verde, C., ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus (2012) Mol. Biosyst., 8, pp. 3295-3304
Berenbrink, M., Koldkjaer, P., Kepp, O., Cossins, A.R., Evolution of oxygen secretion in fishes and the emergence of a complex physiological system (2005) Science, 307 (5716), pp. 1752-1757. , DOI 10.1126/science.1107793
Boechi, L., Marti, M.A., Vergara, A., Sica, F., Mazzarella, L., Estrin, D.A., Merlino, A., Protonation of histidine 55 affects the oxygen access to heme in the alpha chain of the hemoglobin from the Antarctic fish Trematomus bernacchii (2011) IUBMB Life, 63, pp. 175-182
Merlino, A., Vitagliano, L., Howes, B.D., Verde, C., Di Prisco, G., Smulevich, G., Sica, F., Vergara, A., Combined crystallographic and spectroscopic analysis of Trematomus bernacchii hemoglobin highlights analogies and differences in the peculiar oxidation pathway of Antarctic fish hemoglobins (2009) Biopolymers, 91, pp. 1117-1125
Baldwin, J., Chothia, C., Haemoglobin: The structural changes related to ligand binding and its allosteric mechanism (1979) Journal of Molecular Biology, 129 (2), pp. 175-220. , DOI 10.1016/0022-2836(79)90277-8
Balsamo, A., Sannino, F., Merlino, A., Parrilli, E., Tutino, M.L., Mazzarella, L., Vergara, A., Role of the tertiary and quaternary structure in the formation of bis-histidyl adducts in cold-adapted hemoglobins (2012) Biochimie, 94, pp. 953-960
Capece, L., Marti, M.A., Bidon-Chanal, A., Nadra, A., Luque, F.J., Estrin, D.A., High pressure reveals structural determinants for globin hexacoordination: Neuroglobin and myoglobin cases (2009) Proteins, 75, pp. 885-894
Abbruzzetti, S., Faggiano, S., Bruno, S., Spyrakis, F., Mozzarelli, A., Dewilde, S., Moens, L., Viappiani, C., Ligand migration through the internal hydrophobic cavities in human neuroglobin (2009) Proc. Natl. Acad. Sci. U.S.A., 106, pp. 18984-18989
Gabba, M., Abbruzzetti, S., Spyrakis, F., Forti, F., Bruno, S., Mozzarelli, A., Luque, F.J., Dewilde, S., CO rebinding kinetics and molecular dynamics simulations highlight dynamic regulation of internal cavities in human cytoglobin (2013) PLoS One, 8, pp. e49770
Spyrakis, F., Faggiano, S., Abbruzzetti, S., Dominici, P., Cacciatori, E., Astegno, A., Droghetti, E., Luque, F.J., Histidine E7 dynamics modulates ligand exchange between distal pocket and solvent in AHb1 from Arabidopsis thaliana (2011) J. Phys. Chem. B, 115, pp. 4138-4146
Vergara, A., Franzese, M., Merlino, A., Bonomi, G., Verde, C., Giordano, D., Di Prisco, G., Mazzarella, L., Correlation between hemichrome stability and the root effect in tetrameric hemoglobins (2009) Biophys. J., 97, pp. 866-874
Merlino, A., Russo Krauss, I., Castellano, I., De Vendittis, E., Rossi, B., Conte, M., Vergara, A., Sica, F., Structure and flexibility in cold-adapted iron superoxide dismutases: The case of the enzyme isolated from Pseudoalteromonas haloplanktis (2010) J. Struct. Biol., 172, pp. 343-352
Merlino, A., Sica, F., Mazzarella, L., Zagari, A., Vergara, A., Correlation between Raman and X-ray crystallography data of (Pro-Pro-Gly)10 (2008) Biophys. Chem., 137, pp. 24-27
Merlino, A., Verde, C., Di Prisco, G., Mazzarella, L., Vergara, A., Reduction of ferric hemoglobin from Trematomus bernacchii in a partial bis-histidyl state produces a deoxy coordination even when encapsulated into the crystal phase (2008) Spectroscopy, 22 (2-3), pp. 143-152. , DOI 10.3233/SPE-2008-0332, XII European Conference on the Spectroscopy of Biological Molecules, Bobigny, France, 1-6 September 2007, Part 1
Pearson, A.R., Mozzarelli, A., Rossi, G.L., Microspectrophotometry for structural enzymology (2004) Current Opinion in Structural Biology, 14 (6), pp. 656-662. , DOI 10.1016/j.sbi.2004.10.007, PII S0959440X04001836
Vergara, A., Merlino, A., Pizzo, E., D'Alessio, G., Mazzarella, L., A novel method for detection of selenomethionine incorporation in protein crystals via Raman microscopy (2008) Acta Crystallographica Section D: Biological Crystallography, 64 (2), pp. 167-171. , DOI 10.1107/S0907444907058416, PII S0907444907058416
Merlino, A., Fuchs, M.R., Balsamo, A., Pica, F., Dworkowski, F.S., Pompidor, G., Mazzarella, L., Vergara, A., Selective X-ray-induced NO photodissociation in haemoglobin crystals: Evidence from a Raman-assisted crystallographic study (2013) Acta Crystallogr. D: Biol. Crystallogr., 69, pp. 137-140
Camardella, L., Caruso, C., D'Avino, R., Di Prisco, G., Rutigliano, B., Tamburrini, M., Fermi, G., Perutz, M.F., Haemoglobin of the Antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative (1992) J. Mol. Biol., 224, pp. 449-460
Hayashi, A., Suzuki, T., Shin, M., An enzymic reduction system for metmyoglobin and methemoglobin, and its application to functional studies of oxygen carriers (1973) Biochim. Biophys. Acta, 310, pp. 309-316
Rivetti, C., Mozzarelli, A., Rossi, G.L., Henry, E.R., Eaton, W.A., Oxygen binding by single crystals of hemoglobin (1993) Biochemistry, 32 (11), pp. 2888-2906
Dvorak, J.A., Stotler, W.F., A controlled-environment culture system for high resolution light microscopy (1971) Exp. Cell Res., 68, pp. 144-148
Otwinowski, Z., Minor, W., Processing of X-ray diffraction data collected in oscillation mode (1997) Methods in Enzymology, 276, pp. 307-326. , DOI 10.1016/S0076-6879(97)76066-X
Sheldrick, G.M., Schneider, T.R., SHELXL: High-resolution refinement (1997) Methods in Enzymology, 277, pp. 319-343. , DOI 10.1016/S0076-6879(97)77018-6
Jones, T.A., Zou, J.Y., Cowan, S.W., Kjedgaard, M., Improved methods for binding protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr. D: Biol. Crystallogr., 56, pp. 714-721
Hooft, R.W.W., Sander, C., Vriend, G., Verification of protein structures: Side-chain planarity (1996) J. Appl. Crystallogr., 29, pp. 714-716
Laskowski, R.A., Macarthur, M.W., Moss, D.S., Thornton, J.M., PROCHECK: A program to check the stereochemical quality of protein structures (1993) J. Appl. Crystallogr., 26, pp. 283-291
Merlino, A., Howes, B.D., Di Prisco, G., Verde, C., Smulevich, G., Mazzarella, L., Vergara, A., Occurrence and formation of endogenous histidine hexa-coordination in cold-adapted hemoglobins (2011) IUBMB Life, 63, pp. 295-303
Giordano, D., Boechi, L., Vergara, A., Marti, M.A., Samuni, U., Dantsker, D., Grassi, L., Verde, C., The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species - Oxygen-binding equilibria, kinetics and molecular dynamics (2009) FEBS J., 276, pp. 2266-2277
Ronda, L., Bazhulina, N.P., Morozova, E.A., Revtovich, S.V., Chekhov, V.O., Nikulin, A.D., Demidkina, T.V., Mozzarelli, A., Exploring methionine gamma-lyase structure-function relationship via microspectrophotometry and X-ray crystallography (2011) Biochim. Biophys. Acta, 1814, pp. 834-842
Riccio, A., Vitagliano, L., Di Prisco, G., Zagari, A., Mazzarella, L., The crystal structure of a tetrameric hemoglobin in a partial hemichrome state (2002) Proceedings of the National Academy of Sciences of the United States of America, 99 (15), pp. 9801-9806. , DOI 10.1073/pnas.132182099
Vitagliano, L., Vergara, A., Bonomi, G., Merlino, A., Verde, C., Di Prisco, G., Howes, B.D., Mazzarella, L., Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (2008) J. Am. Chem. Soc., 130, pp. 10527-10535
Edelstein, S. J., An allosteric theory for hemoglobin incorporating asymmetric states to test the putative molecular code for cooperativity (1996) Journal of Molecular Biology, 257 (4), pp. 737-744. , DOI 10. 1006/jmbi. 1996. 0198
Eaton, W. A., Henry, E. R., Hofrichter, J., Bettati, S., Viappiani, C., Mozzarelli, A., Evolution of allosteric models for hemoglobin (2007) IUBMB Life, 59 (8-9), pp. 586-599. , DOI 10. 1080/15216540701272380, PII 778359268, IUBMB Life Dedicated to Maurizio Brunori in the Occasion of his 70th Birthday
Henry, E. R., Bettati, S., Hofrichter, J., Eaton, W. A., A tertiary two-state allosteric model for hemoglobin (2002) Biophysical Chemistry, 98 (1-2), pp. 149-164. , DOI 10. 1016/S0301-4622 (02) 00091-1, PII S0301462202000911
Tame, J. R. H., Wilson, J. C., Weber, R. E., The crystal structures of trout Hb I in the deoxy and carbonmonoxy forms (1996) Journal of Molecular Biology, 259 (4), pp. 749-760. , DOI 10. 1006/jmbi. 1996. 0355
Mylvaganam, S. E., Bonaventura, C., Bonaventura, J., Getzoff, E. D., Structural basis for the root effect in haemoglobin (1996) Nature Structural Biology, 3 (3), pp. 275-283. , DOI 10. 1038/nsb0396-275
Pearson, A. R., Mozzarelli, A., Rossi, G. L., Microspectrophotometry for structural enzymology (2004) Current Opinion in Structural Biology, 14 (6), pp. 656-662. , DOI 10. 1016/j. sbi. 2004. 10. 007, PII S0959440X04001836
Dvorak, J. A., Stotler, W. F., A controlled-environment culture system for high resolution light microscopy (1971) Exp. Cell Res., 68, pp. 144-148
Sheldrick, G. M., Schneider, T. R., SHELXL: High-resolution refinement (1997) Methods in Enzymology, 277, pp. 319-343. , DOI 10. 1016/S0076-6879 (97) 77018-6
Jones, T. A., Zou, J. Y., Cowan, S. W., Kjedgaard, M., Improved methods for binding protein models in electron density maps and the location of errors in these models (1991) Acta Crystallogr. D: Biol. Crystallogr., 56, pp. 714-721
Hooft, R. W. W., Sander, C., Vriend, G., Verification of protein structures: Side-chain planarity (1996) J. Appl. Crystallogr., 29, pp. 714-716
Laskowski, R. A., Macarthur, M. W., Moss, D. S., Thornton, J. M., PROCHECK: A program to check the stereochemical quality of protein structures (1993) J. Appl. Crystallogr., 26, pp. 283-291
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(9): 1885-1893.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.191, 5-year impact factor: 3.282
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84884606189&partnerID=40&md5=b53a4d0e0a3c47ea09f0428a3292a62d
Keywords: Hemoglobin, Microspectrophotometry, Oxygen Binding, Root Effect, X-Ray Crystallography, Deoxyhemoglobin, Proton, Allosterism, Article, Binding Affinity, Circular Dichroism, Conformational Transition, Crystal Structure, Ion Exchange Chromatography, Nonhuman, Priority Journal, Protein Tertiary Structure, X Ray Crystallography, Animal, Antarctica, Binding Site, Chemical Structure, Chemistry, Metabolism, Mammalia, Trematomus Bernacchii, Allosteric Regulation, Antarctic Regions, Fishes, Hydrogen-Ion Concentration, Models, Molecular, Protein Structure,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, University of Parma, Parco Area delle Scienze 23/A, 43124 Parma, Italy
Department of Chemical Sciences, University of Naples Federico II, Via Cintia, I-80126, Naples, Italy
Institute of Biostructures and Bioimages, CNR, Naples, Via Mezzocannone 16, 80124, Naples, Italy
Department of Neurosciences, University of Parma, Parco Area delle Scienze 23/A, 43124 Parma, Italy
National Institute of Biostructures and Biosystems, Viale Medaglie d'Oro, 305, 00136 Rome, Italy
Institute of Protein Biochemistry, CNR, Via Pietro Castellino, 111, I-80131 Naples, Italy
References:
Bonaventura, C., Crumbliss, A.L., Weber, R.E., New insights into the proton-dependent oxygen affinity of Root effect haemoglobins (2004) Acta Physiologica Scandinavica, 182 (3), pp. 245-258. , DOI 10.1111/j.1365-201X.2004.01359.
Brittain, T., Root effect hemoglobins (2005) Journal of Inorganic Biochemistry, 99 (1), pp. 120-129. , DOI 10.1016/j.jinorgbio.2004.09.025, PII S0162013404002922, Heme-Diatomic Interactions, Part 1
Verde, C., Vergara, A., Mazzarella, L., Di Prisco, G., The hemoglobins of fishes living at polar latitudes - Current knowledge on structural adaptations in a changing environment (2008) Curr. Protein Pept. Sci., 9, pp. 578-590
Monod, J., Wyman, J., Changeux, J.P., On the nature of allosteric transitions: A plausible model (1965) J. Mol. Biol., 12, pp. 88-118
Edelstein, S.J., An allosteric theory for hemoglobin incorporating asymmetric states to test the putative molecular code for cooperativity (1996) Journal of Molecular Biology, 257 (4), pp. 737-744. , DOI 10.1006/jmbi.1996.0198
Eaton, W.A., Henry, E.R., Hofrichter, J., Bettati, S., Viappiani, C., Mozzarelli, A., Evolution of allosteric models for hemoglobin (2007) IUBMB Life, 59 (8-9), pp. 586-599. , DOI 10.1080/15216540701272380, PII 778359268, IUBMB Life Dedicated to Maurizio Brunori in the Occasion of his 70th Birthday
Henry, E.R., Bettati, S., Hofrichter, J., Eaton, W.A., A tertiary two-state allosteric model for hemoglobin (2002) Biophysical Chemistry, 98 (1-2), pp. 149-164. , DOI 10.1016/S0301-4622(02)00091-1, PII S0301462202000911
Viappiani, C., Bettati, S., Bruno, S., Ronda, L., Abbruzzetti, S., Mozzarelli, A., Eaton, W.A., New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels (2004) Proceedings of the National Academy of Sciences of the United States of America, 101 (40), pp. 14414-14419. , DOI 10.1073/pnas.0405987101
Tsuneshige, A., Park, S., Yonetani, T., Heterotropic effectors control the hemoglobin function by interacting with its T and R states - A new view on the principle of allostery (2002) Biophysical Chemistry, 98 (1-2), pp. 49-63. , DOI 10.1016/S0301-4622(02)00084-4, PII S0301462202000844
Bettati, S., Kwiatkowski, L.D., Kavanaugh, J.S., Mozzarelli, A., Arnone, A., Rossi, G.L., Noble, R.W., Structure and oxygen affinity of crystalline des-His-146β human hemoglobin in the T state (1997) Journal of Biological Chemistry, 272 (52), pp. 33077-33084. , DOI 10.1074/jbc.272.52.33077
Bettati, S., Mozzarelli, A., Perutz, M.F., Allosteric mechanism of haemoglobin: Rupture of salt-bridges raises the oxygen affinity of the T-structure (1998) Journal of Molecular Biology, 281 (4), pp. 581-585. , DOI 10.1006/jmbi.1998.1983
Mozzarelli, A., Bettati, S., Rivetti, C., Rossi, G.L., Colotti, G., Chiancone, E., Cooperative oxygen binding to Scapharca inaequivalvis hemoglobin in the crystal (1996) Journal of Biological Chemistry, 271 (7), pp. 3627-3632. , DOI 10.1074/jbc.271.7.3627
Mozzarelli, A., Rivetti, C., Rossi, G.L., Eaton, W.A., Henry, E.R., Allosteric effectors do not alter the oxygen affinity of hemoglobin crystals (1997) Protein Science, 6 (2), pp. 484-489
Mozzarelli, A., Rossi, G.L., Protein function in the crystal (1996) Annual Review of Biophysics and Biomolecular Structure, 25, pp. 343-365
Bruno, S., Bonaccio, M., Bettati, S., Rivetti, C., Viappiani, C., Abbruzzetti, S., Mozzarelli, A., High and low oxygen affinity conformations of T state hemoglobin (2001) Protein Science, 10 (11), pp. 2401-2407. , DOI 10.1110/ps.20501
Ronda, L., Bruno, S., Viappiani, C., Abbruzzetti, S., Mozzarelli, A., Lowe, K.C., Bettati, S., Circular dichroism spectroscopy of tertiary and quaternary conformations of human hemoglobin entrapped in wet silica gels (2006) Protein Science, 15 (8), pp. 1961-1967. , http://www.proteinscience.org/cgi/reprint/15/8/1961, DOI 10.1110/ps.062272306
Tame, J.R.H., Wilson, J.C., Weber, R.E., The crystal structures of trout Hb I in the deoxy and carbonmonoxy forms (1996) Journal of Molecular Biology, 259 (4), pp. 749-760. , DOI 10.1006/jmbi.1996.0355
Mylvaganam, S.E., Bonaventura, C., Bonaventura, J., Getzoff, E.D., Structural basis for the root effect in haemoglobin (1996) Nature Structural Biology, 3 (3), pp. 275-283. , DOI 10.1038/nsb0396-275
Yokoyama, T., Chong, K.T., Miyazaki, G., Morimoto, H., Shih, D.T.-B., Unzai, S., Tame, J.R.H., Park, S.-Y., Novel mechanisms of pH sensitivity in tuna hemoglobin. A structural explanation of the root effect (2004) Journal of Biological Chemistry, 279 (27), pp. 28632-28640. , DOI 10.1074/jbc.M401740200
Mazzarella, L., Bonomi, G., Lubrano, M.C., Merlino, A., Riccio, A., Vergara, A., Vitagliano, L., Di Prisco, G., Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (2006) Proteins: Structure, Function and Genetics, 62 (2), pp. 316-321. , DOI 10.1002/prot.20709
Mazzarella, L., Vergara, A., Vitagliano, L., Merlino, A., Bonomi, G., Scala, S., Verde, C., Di Prisco, G., High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (2006) Proteins: Structure, Function and Genetics, 65 (2), pp. 490-498. , DOI 10.1002/prot.21114
Coppola, D., Abbruzzetti, S., Nicoletti, F., Merlino, A., Gambacurta, A., Giordano, D., Howes, B.D., Verde, C., ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus (2012) Mol. Biosyst., 8, pp. 3295-3304
Berenbrink, M., Koldkjaer, P., Kepp, O., Cossins, A.R., Evolution of oxygen secretion in fishes and the emergence of a complex physiological system (2005) Science, 307 (5716), pp. 1752-1757. , DOI 10.1126/science.1107793
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Role of tertiary structures on the Root effect in fish hemoglobins
Many fish hemoglobins exhibit a marked dependence of oxygen affinity and cooperativity on proton concentration, called Root effect. Both tertiary and quaternary effects have been evoked to explain the allosteric regulation brought about by protons in fish hemoglobins. However, no general rules have emerged so far. We carried out a complementary crystallographic and microspectroscopic characterization of ligand binding to crystals of deoxy-hemoglobin from the Antarctic fish Trematomus bernacchii (HbTb) at pH 6.2 and pH 8.4. At low pH ligation has negligible structural effects, correlating with low affinity and absence of cooperativity in oxygen binding. At high pH, ligation causes significant changes at the tertiary structural level, while preserving structural markers of the T state. These changes mainly consist in a marked displacement of the position of the switch region CD corner towards an R-like position. The functional data on T-state crystals validate the relevance of the crystallographic observations, revealing that, differently from mammalian Hbs, in HbTb a significant degree of cooperativity in oxygen binding is due to tertiary conformational changes, in the absence of the T-R quaternary transition. This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. (c) 2013 Elsevier B.V. All rights reserved.
Many fish hemoglobins exhibit a marked dependence of oxygen affinity and cooperativity on proton concentration, called Root effect. Both tertiary and quaternary effects have been evoked to explain the allosteric regulation brought about by protons in fish hemoglobins. However, no general rules have emerged so far. We carried out a complementary crystallographic and microspectroscopic characterization of ligand binding to crystals of deoxy-hemoglobin from the Antarctic fish Trematomus bernacchii (HbTb) at pH 6.2 and pH 8.4. At low pH ligation has negligible structural effects, correlating with low affinity and absence of cooperativity in oxygen binding. At high pH, ligation causes significant changes at the tertiary structural level, while preserving structural markers of the T state. These changes mainly consist in a marked displacement of the position of the switch region CD corner towards an R-like position. The functional data on T-state crystals validate the relevance of the crystallographic observations, revealing that, differently from mammalian Hbs, in HbTb a significant degree of cooperativity in oxygen binding is due to tertiary conformational changes, in the absence of the T-R quaternary transition. This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. (c) 2013 Elsevier B.V. All rights reserved.
Role of tertiary structures on the Root effect in fish hemoglobins
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Role of tertiary structures on the Root effect in fish hemoglobins
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* Occurrence and formation of endogenous histidine hexa-coordination in cold-adapted hemoglobins (410 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 May; 63(5): 295-303.
Impact Factor: 3.514
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Riccio A, Mangiapia G, Giordano D, Flagiello A, Tedesco R, Bruno S, Vergara A, Mazzarella L, di Prisco G, Pucci P, Paduano L, Verde C
* Polymerization of Hemoglobins in Arctic Fish: Lycodes reticulatus and Gadus morhua (465 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 May; 63(5): 346-354.
Impact Factor: 3.514
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Boechi L, Marti MA, Vergara A, Sica F, Mazzarella L, Estrin DA, Merlino A
* Protonation of Histidine 55 Affects the Oxygen Access to Heme in the Alpha Chain of the Hemoglobin from the Antarctic Fish Trematomus bernacchii (370 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 Mar; 63(3): 175-182.
Impact Factor: 3.514
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Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (461 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
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Merlino A, Vitagliano L, Balsamo A, Nicoletti FP, Howes BD, Giordano D, Coppola D, Di Prisco G, Verde C, Smulevich G, Mazzarella L, Vergara A
* Crystallization, preliminary X-ray diffraction studies and Raman microscopy of the major haemoglobin from the sub-Antarctic fish Eleginops maclovinus in the carbomonoxy form (317 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2010 Nov; 66: 1536-1540.
Impact Factor: 0.563
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Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L
* An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins (363 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Oct 15; 285(42): 32568-32575.
Impact Factor: 5.328
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Coppola D, Giordano D, Vergara A, Mazzarella L, Di Prisco G, Verde C, Russo R
* The hemoglobins of sub-Antarctic fishes of the suborder Notothenioidei (434 views)
Polar Science (ISSN: 1873-9652), 2010 Sep; 4(2): 295-308.
Impact Factor: 31.477
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Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (352 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605.
Impact Factor: 2.661
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Mainenti PP, Segreto S, Mancini M, Rispo A, Cozzolino I, Masone S, Rinaldi CR, Nardone G, Salvatore M
* Intestinal amyloidosis: two cases with different patterns of clinical and imaging presentation (386 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2010 May 28; 16(20): 2566-2570.
Impact Factor: 2.24
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Merlino A, Vergara A, Sica F, Aschi M, Amadei A, Di Nola A, Mazzarella L
* Free-Energy Profile for CO Binding to Separated Chains of Human and Trematomus newnesi Hemoglobin: Insights from Molecular Dynamics Simulations and Perturbed Matrix Method (301 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 May 27; 114(20): 7002-7008.
Impact Factor: 3.603
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (400 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Guler OO, De Simone G, Supuran CT
* Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (541 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526.
Impact Factor: 4.63
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Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
* Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (416 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1117-1125.
Impact Factor: 2.605
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Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L
* The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (436 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008.
Impact Factor: 3.085
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Risitano AM, Seneca E, Marando L, Imbriaco M, Soscia E, Soscia F, Pizzuti LM, Malcovati L, Fenu S, Iori AP, Notaro R, Matarazzo M, Rotoli B
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Haematologica (ISSN: 0006-4971, 0006-6497, 0390-6078), 2009 Nov 20; 114(22): N/D-N/D.
Impact Factor: 10.555
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (398 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Vergara A, Franzese M, Merlino A, Bonomi G, Verde C, Giordano D, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Correlation between Hemichrome Stability and the Root Effect in Tetrameric Hemoglobins (407 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2009 Sep 5; 97(3): 866-874.
Impact Factor: 4.39
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Giordano D, Boechi L, Vergara A, Marti MA, Samuni U, Dantsker D, Grassi L, Estrin DA, Friedman JM, Mazzarella L, Di Prisco G, Verde C
* The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species - oxygen-binding equilibria, kinetics and molecular dynamics (709 views)
Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(8): 2266-2277.
Impact Factor: 3.042
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Verde C, Giordano D, Russo R, Riccio A, Vergara A, Mazzarella L, Di Prisco G
* Hemoproteins in the cold (276 views)
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 67-73.
Impact Factor: 1.2
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Wekselman I, Davidovich C, Agmon I, Zimmerman E, Rozenberg H, Bashan A, Berisio R, Yonath A
* Ribosome's mode of function: Myths, facts and recent results (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 122-130.
Impact Factor: 1.807
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Merlino A, Vergara A, Sica F, Mazzarella L
* The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins (334 views)
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 51-56.
Impact Factor: 1.2
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Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
* X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (432 views)
Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 73-138.
Impact Factor: 1.156
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Verde C, Vergara A, Mazzarella L, Di Prisco G
* The Hemoglobins of Fishes Living at Polar Latitudes - Current Knowledge on Structural Adaptations in a Changing Environment (389 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Dec; 9(6): 578-590.
Impact Factor: 3.011
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Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (1034 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (400 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
Impact Factor: 8.091
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Merlino A, Sica F, Mazzarella L, Zagari A, Vergara A
* Correlation between Raman and X-ray crystallography data of (Pro-Pro-Gly)(10) (444 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2008 Sep; 137(1): 24-27.
Impact Factor: 2.362
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Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (417 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
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Merlino A, Verde C, Di Prisco G, Mazzarella L, Vergara A
* Reduction of ferric hemoglobin from Trematomus bernacchii in a partial bis-histidyl state produces a deoxy coordination even when encapsulated into the crystal phase (414 views)
Spectroscopy An International Journal (ISSN: 0712-4813), 2008; 22(2-3): 143-152.
Impact Factor: 0.82
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of A Tetrameric Hemoglobin Oxidation Pathway Reveals Structural Features Of A Functional Intermediate R/T State (278 views)
Biophys J, 2008; 94: 4031-4040.
Impact Factor: 3.832
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Vergara A, Vitagliano L, Verde C, di Prisco G, Mazzarella L
* Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins (426 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 2008; 436: 425-444.
Impact Factor: 2.312
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Vergara A, Vitagliano L, Di Prisco G, Verde C, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of Hemichromes In Tetrameric Hemoglobins (321 views)
Methods In Enzymology, 2008; 436: 421-440.
Impact Factor: 2.194
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Giordano D, Vergara A, Lee HC, Peisach J, Balestrieri M, Mazzarella L, Parisi E, Di Priseo G, Verde C
* Hemoglobin structure/function and globin-gene evolution in the Arctic fish Liparis tunicatus (408 views)
Gene (ISSN: 0378-1119), 2007 Dec 30; 406(1-2): 58-68.
Impact Factor: 2.871
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (495 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1007 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vergara A, Franzese M, Merlino A, Vitagliano L, Verde C, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Structural characterization of ferric hemoglobins from three Antarctic fish species of the suborder notothenioidei (375 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Oct; 93(8): 2822-2829.
Impact Factor: 4.627
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Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (330 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Sep 1; 17(15): 4201-4207.
Impact Factor: 2.604
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Verde C, Vergara A, Giordano D, Mazzarella L, Di Prisco G
* The Root effect - a structural and evolutionary perspective (251 views)
Antarctic Science (ISSN: 0954-1020), 2007 Jun; 19(2): 271-278.
Impact Factor: 1.265
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Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (411 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
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Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (310 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Dec 15; 16(24): 6204-6208.
Impact Factor: 2.538
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Mazzarella L, Vergara A, Vitagliano L, Merlino A, Bonomi G, Scala S, Verde C, Di Prisco G
* High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (402 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Nov 1; 65(2): 490-498.
Impact Factor: 3.73
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Mazzarella L, Bonomi G, Lubrano MC, Merlino A, Riccio A, Vergara A, Vitagliano L, Verde C, Di Prisco G
* Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (507 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 1; 62(2): 316-321.
Impact Factor: 3.73
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Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (323 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
Impact Factor: 2.538
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Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (496 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
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Vitagliano L, Bonomi G, Franzese M, Merlino A, Vergara A, Verde C, Di Prisco G, Mazzarella L
* Structural Characterization Of The Oxidation Pathway Of Antarctic Fish Hemoglobins (313 views)
Acta Crystallogr D Biol Crystallogr, 2005; N/D: N/D-N/D.
Impact Factor: 2.069
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Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (379 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
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Vitagliano L, Bonomi G, Riccio A, di Prisco G, Smulevich G, Mazzarella L
* The oxidation process of Antarctic fish hemoglobins (454 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 May; 271(9): 1651-1659.
Impact Factor: 3.26
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* The crystal structure of a tetrameric hemoglobin in a partial hemichrome state (553 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2002 Jul 23; 99(15): 9801-9806.
Impact Factor: 10.7
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Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (476 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
Impact Factor: 5.359
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Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (1166 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* Liganded and unliganded forms of Antarctic fish haemoglobins in polyethylene glycol: crystallization of an R-state haemichrome intermediate (401 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2001 Sep; 57: 1144-1146.
Impact Factor: 2.124
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Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (602 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
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Mazzarella L, D'Avino R, Di Prisco G, Savino C, Vitagliano L, Moody P, Zagari A
Crystal structure of Trematomus newnesi haemoglobin re-opens the Root effect question (435 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Apr 16; 287(5): 897-906.
Impact Factor: 5.501
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Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC
Hydroxyurea reacts with heme proteins to generate nitric oxide [6] (369 views)
Lancet (ISSN: 0140-6736), 1996 Mar 30; 347(9005): 900-900.
Impact Factor: 16.135
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (588 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Manna R, Salvatore M, Di Leo MA, Scuderi F, Greco AV, Ghirlanda G, Gambassi G
Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes (432 views)
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
Impact Factor: 0
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Salvati AM, d'Onofrio G, Berti P, Cappabianca MP, Marsili G, De Philippis C, Cossa L, Quarantelli M, Zini G, Mango G
An assessment of the operating characteristics of Coulter Counter model S-Plus STKR (585 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1991 Mar; 76(2): 94-103.
Impact Factor: 2.56
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* Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII (27 views)
Bioorg Med Chem (ISSN: 0968-0896linking, 1464-3391), 2021 Aug 15; 44: 116279-116279.
Impact Factor: 3.641
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Balasco N, Vitagliano L, Merlino A, Verde C, Mazzarella L, Vergara A
* The unique structural features of carbonmonoxy hemoglobin from the sub-Antarctic fish Eleginops maclovinus (176 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Dec 12; 9(1): 18987-18987.
Impact Factor: 5.078
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Langella E, Alterio V, D'Ambrosio K, Cadoni R, Winum JY, Supuran CT, Monti SM, De Simone G, Di Fiore A
* Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity (243 views)
J Enzym Inhib Med Ch (ISSN: 1475-6366linking, 1475-6374electronic), 2019 Dec; 34(1): 1498-1505.
Impact Factor: 4.027
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Esposito L, Donnarumma F, Ruggiero A, Leone S, Vitagliano L, Picone D
* Structure, stability and aggregation propensity of a Ribonuclease A-Onconase chimera (292 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jul 15; 133: 1125-1133.
Impact Factor: 4.784
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Buemi MR, Di Fiore A, De Luca L, Angeli A, Mancuso F, Ferro S, Monti SM, Buonanno M, Russo E, De Sarro G, De Simone G, Supuran CT, Gitto R
* Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety (327 views)
Eur J Med Chem (ISSN: 1768-3254electronic, 0223-5234linking), 2019 Feb 1; 163: 443-452.
Impact Factor: 4.833
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Alterio V, Esposito D, Monti SM, Supuran CT, De Simone G
* Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2, 4, 6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor (533 views)
J Enzym Inhib Med Ch (ISSN: 1475-6374electronic, 1475-6366linking), 2018 Dec; 33(1): 151-157.
Impact Factor: 4.293
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Mazzarella L, Merlino A, Balasco N, Balsamo A, Vergara A
* Crystal structure of the ferric homotetrameric beta4 human hemoglobin (242 views)
Biophys Chem (ISSN: 0301-4622linking), 2018 Sep; 240: 9-14.
Impact Factor: 1.87
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Merlino A, Marzo T, Messori L
* Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy (233 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 May 23; 23(29): 6942-6947.
Impact Factor: 5.16
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Vitagliano L, Mazzarella L, Merlino A, Vergara A
* Fine Sampling of the R--> T Quaternary-Structure Transition of a Tetrameric Hemoglobin (346 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Jan 12; 23(3): 605-613.
Impact Factor: 5.16
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Vullo D, Supuran CT, Scozzafava A, De Simone G, Monti SM, Alterio V, Carta F
* Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1, 6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors (257 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2016 Aug 15; 24(16): 3643-3648.
Impact Factor: 2.93
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Caviglia GP, Cabianca L, Fagoonee S, Gili FM
* Colorectal cancer detection in an asymptomatic population: Fecal immunochemical test for hemoglobin vs. Fecal M2-type pyruvate kinase (329 views)
Biochem Medica (ISSN: 1330-0962), 2016; 26(1): 114-120.
Impact Factor: 2.934
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Pica A, Chi M-C, Chen Y-Y, D'Ischia M, Lin L-L, Merlino A
* The maturation mechanism of γ-glutamyl transpeptidases: Insights from the crystal structure of a precursor mimic of the enzyme from Bacillus licheniformis and from site-directed mutagenesis studies (417 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2016; 1864(2): 195-203.
Impact Factor: 5.476
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Messori L, Marzo T, Merlino A
* Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts (312 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; N/D: N/D-N/D.
Impact Factor: 3.205
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Bisconte MG, Caldora M, Musollino G, Cardiero G, Flagiello A, La Porta G, Lagona L, Prezioso R, Qualtieri G, Gaudiano C, Medulla E, Merlino A, Pucci P, Lacerra G
* α-thalassemia associated with Hb instability: A tale of two features. The case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro (421 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015; 10(3): N/D-N/D.
Impact Factor: 3.057
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D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
* Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis (456 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Feb; 97(1): 114-120.
Impact Factor: 2.963
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (431 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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Alcides Petruk A, Vergara A, Estrin D, Merlino A
* Molecular basis of the NO trans influence in quaternary T-state human hemoglobin: A computational study (415 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013 Sep 2; 587(15): 2393-2398.
Impact Factor: 3.341
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (314 views)
Diabetes Care (ISSN: 1935-5548, 0149-5992), 2013 Sep; 36(8): 2395-2401.
Impact Factor: 8.57
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De Simone G, Alterio V, Supuran CT
* Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (509 views)
Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
Impact Factor: 3.467
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Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A
* Selective X-ray-induced NO photodissociation in haemoglobin crystals: evidence from a Raman-assisted crystallographic study (339 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Jan; 69: 137-140.
Impact Factor: 7.232
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Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A
* Selective X-Ray Induced No-Photodissociation In Hemoglobin Crystals: Evidence From A Raman Assisted-Crystallographic Study (302 views)
Acta Cryst D 69, 2013; 1: 137-140.
Impact Factor: 0
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Fonti R, Larobina M, Del Vecchio S, Fabbricini R, Catalano L, Pane F, Salvatore M, Pace L
* Metabolic tumor volume assessed by 18F-FDG PET/CT for the prediction of outcome in patients with multiple myeloma (588 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Dec; 53(12): 1829-1835.
Impact Factor: 5.774
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Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C
* ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus (343 views)
Molecular Biosystems (ISSN: 1742-206x), 2012 Oct 30; 8(12): 3295-3304.
Impact Factor: 3.35
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Risitano AM, Imbriaco M, Marando L, Seneca E, Soscia E, Malcovati L, Iori AP, Pane F, Notaro R, Matarazzo M
* From perpetual haemosiderinuria to possible iron overload: iron redistribution in paroxysmal nocturnal haemoglobinuria patients on eculizumab by magnetic resonance imaging (360 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2012 Sep; 158(3): 415-418.
Impact Factor: 4.942
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De Rosa A, Rossi F, Lieto M, Bruno R, De Renzo A, Palma V, Quarantelli M, De Michele G
* Subacute combined degeneration of the spinal cord in a vegan (363 views)
Clin Neurol Neurosurg (ISSN: 0303-8467), 2012 Sep; 114(7): 1000-1002.
Impact Factor: 1.234
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Marciano C, Galderisi M, Gargiulo P, Acampa W, D'Amore C, Esposito R, Capasso E, Savarese G, Casaretti L, Lo Iudice F, Esposito G, Rengo G, Leosco D, Cuocolo A, Perrone-Filardi P
* Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (917 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Jul; 39(7): 1199-1206.
Impact Factor: 5.114
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De Simone G, Supuran CT
* (In)organic anions as carbonic anhydrase inhibitors (442 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2012 Jun; 111: 117-129.
Impact Factor: 3.197
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Balsamo A, Sannino F, Merlino A, Parrilli E, Tutino ML, Mazzarella L, Vergara A
* Role of the tertiary and quaternary structure in the formation of bis-histidyl adducts in cold-adapted hemoglobins (485 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 Apr; 94(4): 953-960.
Impact Factor: 3.142
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Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (549 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
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Esposito L, Ruggiero A, Masullo M, Ruocco MR, Lamberti A, Arcari P, Zagari A, Vitagliano L
* Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability (301 views)
J Struct Biol (ISSN: 1047-8477, 1047-8477linking), 2012 Feb; 177(2): 506-512.
Impact Factor: 3.361
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Merlino A, Russo Krauss I, Albino A, Pica A, Vergara A, Masullo M, De Vendittis E, Sica F
* Improving Protein Crystal Quality by the Without-Oil Microbatch Method: Crystallization and Preliminary X-ray Diffraction Analysis of Glutathione Synthetase from Pseudoalteromonas haloplanktis (365 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2011 Sep; 12(9): 6312-6319.
Impact Factor: 2.598
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Striano P, Caranci F, Pappata S, Zara F, Striano S
* Hemidystonia in uncontrolled type 2 diabetes mellitus (291 views)
Arch Neurol (ISSN: 1538-3687electronic, 0003-9942linking), 2011 May; 68(5): 674-675.
Impact Factor: 7.584
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Merlino A, Howes BD, Prisco G, Verde C, Smulevich G, Mazzarella L, Vergara A
* Occurrence and formation of endogenous histidine hexa-coordination in cold-adapted hemoglobins (410 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 May; 63(5): 295-303.
Impact Factor: 3.514
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Riccio A, Mangiapia G, Giordano D, Flagiello A, Tedesco R, Bruno S, Vergara A, Mazzarella L, di Prisco G, Pucci P, Paduano L, Verde C
* Polymerization of Hemoglobins in Arctic Fish: Lycodes reticulatus and Gadus morhua (465 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 May; 63(5): 346-354.
Impact Factor: 3.514
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Boechi L, Marti MA, Vergara A, Sica F, Mazzarella L, Estrin DA, Merlino A
* Protonation of Histidine 55 Affects the Oxygen Access to Heme in the Alpha Chain of the Hemoglobin from the Antarctic Fish Trematomus bernacchii (370 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 Mar; 63(3): 175-182.
Impact Factor: 3.514
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Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (461 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
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Merlino A, Vitagliano L, Balsamo A, Nicoletti FP, Howes BD, Giordano D, Coppola D, Di Prisco G, Verde C, Smulevich G, Mazzarella L, Vergara A
* Crystallization, preliminary X-ray diffraction studies and Raman microscopy of the major haemoglobin from the sub-Antarctic fish Eleginops maclovinus in the carbomonoxy form (317 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2010 Nov; 66: 1536-1540.
Impact Factor: 0.563
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Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L
* An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins (363 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Oct 15; 285(42): 32568-32575.
Impact Factor: 5.328
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Coppola D, Giordano D, Vergara A, Mazzarella L, Di Prisco G, Verde C, Russo R
* The hemoglobins of sub-Antarctic fishes of the suborder Notothenioidei (434 views)
Polar Science (ISSN: 1873-9652), 2010 Sep; 4(2): 295-308.
Impact Factor: 31.477
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Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (352 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2010 Jun 15; 20(12): 3601-3605.
Impact Factor: 2.661
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Mainenti PP, Segreto S, Mancini M, Rispo A, Cozzolino I, Masone S, Rinaldi CR, Nardone G, Salvatore M
* Intestinal amyloidosis: two cases with different patterns of clinical and imaging presentation (386 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2010 May 28; 16(20): 2566-2570.
Impact Factor: 2.24
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Merlino A, Vergara A, Sica F, Aschi M, Amadei A, Di Nola A, Mazzarella L
* Free-Energy Profile for CO Binding to Separated Chains of Human and Trematomus newnesi Hemoglobin: Insights from Molecular Dynamics Simulations and Perturbed Matrix Method (301 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 May 27; 114(20): 7002-7008.
Impact Factor: 3.603
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (400 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Guler OO, De Simone G, Supuran CT
* Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII (541 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2010; 17(15): 1516-1526.
Impact Factor: 4.63
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Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
* Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (416 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1117-1125.
Impact Factor: 2.605
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Ruggiero A, Masullo M, Marasco D, Ruocco MR, Grimaldi P, Arcari P, Zagari A, Vitagliano L
* The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability (436 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2009 Dec; 77(4): 1004-1008.
Impact Factor: 3.085
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Risitano AM, Seneca E, Marando L, Imbriaco M, Soscia E, Soscia F, Pizzuti LM, Malcovati L, Fenu S, Iori AP, Notaro R, Matarazzo M, Rotoli B
* From Renal Siderosis Due to Perpetual Hemosiderinuria to Possible Liver Overload Due to Extravascular Hemolysis: Changes in Iron Metabolism in Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients On Eculizumab (353 views)
Haematologica (ISSN: 0006-4971, 0006-6497, 0390-6078), 2009 Nov 20; 114(22): N/D-N/D.
Impact Factor: 10.555
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (398 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Vergara A, Franzese M, Merlino A, Bonomi G, Verde C, Giordano D, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Correlation between Hemichrome Stability and the Root Effect in Tetrameric Hemoglobins (407 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2009 Sep 5; 97(3): 866-874.
Impact Factor: 4.39
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Giordano D, Boechi L, Vergara A, Marti MA, Samuni U, Dantsker D, Grassi L, Estrin DA, Friedman JM, Mazzarella L, Di Prisco G, Verde C
* The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species - oxygen-binding equilibria, kinetics and molecular dynamics (709 views)
Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(8): 2266-2277.
Impact Factor: 3.042
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Verde C, Giordano D, Russo R, Riccio A, Vergara A, Mazzarella L, Di Prisco G
* Hemoproteins in the cold (276 views)
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 67-73.
Impact Factor: 1.2
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Wekselman I, Davidovich C, Agmon I, Zimmerman E, Rozenberg H, Bashan A, Berisio R, Yonath A
* Ribosome's mode of function: Myths, facts and recent results (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 122-130.
Impact Factor: 1.807
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Merlino A, Vergara A, Sica F, Mazzarella L
* The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins (334 views)
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 51-56.
Impact Factor: 1.2
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Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
* X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (432 views)
Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 73-138.
Impact Factor: 1.156
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Verde C, Vergara A, Mazzarella L, Di Prisco G
* The Hemoglobins of Fishes Living at Polar Latitudes - Current Knowledge on Structural Adaptations in a Changing Environment (389 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Dec; 9(6): 578-590.
Impact Factor: 3.011
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Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (1034 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (400 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
Impact Factor: 8.091
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Merlino A, Sica F, Mazzarella L, Zagari A, Vergara A
* Correlation between Raman and X-ray crystallography data of (Pro-Pro-Gly)(10) (444 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2008 Sep; 137(1): 24-27.
Impact Factor: 2.362
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Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (417 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
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Merlino A, Verde C, Di Prisco G, Mazzarella L, Vergara A
* Reduction of ferric hemoglobin from Trematomus bernacchii in a partial bis-histidyl state produces a deoxy coordination even when encapsulated into the crystal phase (414 views)
Spectroscopy An International Journal (ISSN: 0712-4813), 2008; 22(2-3): 143-152.
Impact Factor: 0.82
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of A Tetrameric Hemoglobin Oxidation Pathway Reveals Structural Features Of A Functional Intermediate R/T State (278 views)
Biophys J, 2008; 94: 4031-4040.
Impact Factor: 3.832
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Vergara A, Vitagliano L, Verde C, di Prisco G, Mazzarella L
* Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins (426 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 2008; 436: 425-444.
Impact Factor: 2.312
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Vergara A, Vitagliano L, Di Prisco G, Verde C, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of Hemichromes In Tetrameric Hemoglobins (321 views)
Methods In Enzymology, 2008; 436: 421-440.
Impact Factor: 2.194
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Giordano D, Vergara A, Lee HC, Peisach J, Balestrieri M, Mazzarella L, Parisi E, Di Priseo G, Verde C
* Hemoglobin structure/function and globin-gene evolution in the Arctic fish Liparis tunicatus (408 views)
Gene (ISSN: 0378-1119), 2007 Dec 30; 406(1-2): 58-68.
Impact Factor: 2.871
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (495 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1007 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vergara A, Franzese M, Merlino A, Vitagliano L, Verde C, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Structural characterization of ferric hemoglobins from three Antarctic fish species of the suborder notothenioidei (375 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Oct; 93(8): 2822-2829.
Impact Factor: 4.627
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Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (330 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Sep 1; 17(15): 4201-4207.
Impact Factor: 2.604
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Verde C, Vergara A, Giordano D, Mazzarella L, Di Prisco G
* The Root effect - a structural and evolutionary perspective (251 views)
Antarctic Science (ISSN: 0954-1020), 2007 Jun; 19(2): 271-278.
Impact Factor: 1.265
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Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (411 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
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Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT
* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II (310 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Dec 15; 16(24): 6204-6208.
Impact Factor: 2.538
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Mazzarella L, Vergara A, Vitagliano L, Merlino A, Bonomi G, Scala S, Verde C, Di Prisco G
* High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (402 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Nov 1; 65(2): 490-498.
Impact Factor: 3.73
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Mazzarella L, Bonomi G, Lubrano MC, Merlino A, Riccio A, Vergara A, Vitagliano L, Verde C, Di Prisco G
* Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (507 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 1; 62(2): 316-321.
Impact Factor: 3.73
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Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib (323 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2006 Jan 15; 16(2): 437-442.
Impact Factor: 2.538
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Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (496 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
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Vitagliano L, Bonomi G, Franzese M, Merlino A, Vergara A, Verde C, Di Prisco G, Mazzarella L
* Structural Characterization Of The Oxidation Pathway Of Antarctic Fish Hemoglobins (313 views)
Acta Crystallogr D Biol Crystallogr, 2005; N/D: N/D-N/D.
Impact Factor: 2.069
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Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (379 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
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Vitagliano L, Bonomi G, Riccio A, di Prisco G, Smulevich G, Mazzarella L
* The oxidation process of Antarctic fish hemoglobins (454 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 May; 271(9): 1651-1659.
Impact Factor: 3.26
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* The crystal structure of a tetrameric hemoglobin in a partial hemichrome state (553 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2002 Jul 23; 99(15): 9801-9806.
Impact Factor: 10.7
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Esposito L, Sica F, Raia CA, Giordano A, Rossi M, Mazzarella L, Zagari A
* Crystal Structure Of The Alcohol Dehydrogenase From The Hyperthermophilic Archaeon Sulfolobus Solfataricus At 1. 85 Angstrom Resolution (476 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Apr 26; 318(2): 463-477.
Impact Factor: 5.359
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Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (1166 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* Liganded and unliganded forms of Antarctic fish haemoglobins in polyethylene glycol: crystallization of an R-state haemichrome intermediate (401 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2001 Sep; 57: 1144-1146.
Impact Factor: 2.124
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Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (602 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
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Mazzarella L, D'Avino R, Di Prisco G, Savino C, Vitagliano L, Moody P, Zagari A
Crystal structure of Trematomus newnesi haemoglobin re-opens the Root effect question (435 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Apr 16; 287(5): 897-906.
Impact Factor: 5.501
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Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC
Hydroxyurea reacts with heme proteins to generate nitric oxide [6] (369 views)
Lancet (ISSN: 0140-6736), 1996 Mar 30; 347(9005): 900-900.
Impact Factor: 16.135
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (588 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Manna R, Salvatore M, Di Leo MA, Scuderi F, Greco AV, Ghirlanda G, Gambassi G
Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes (432 views)
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
Impact Factor: 0
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Salvati AM, d'Onofrio G, Berti P, Cappabianca MP, Marsili G, De Philippis C, Cossa L, Quarantelli M, Zini G, Mango G
An assessment of the operating characteristics of Coulter Counter model S-Plus STKR (585 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1991 Mar; 76(2): 94-103.
Impact Factor: 2.56
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88 Records (84 excluding Abstracts).
Total impact factor: 368.745 (334.212 excluding Abstracts).
Total 5 year impact factor: 412.834 (355.094 excluding Abstracts).
Total impact factor: 368.745 (334.212 excluding Abstracts).
Total 5 year impact factor: 412.834 (355.094 excluding Abstracts).
544 views. Last view on Monday 24 April 2023, 11:24:59
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