Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (470 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
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Paper type: Journal Article,
Impact factor: 0.825, 5-year impact factor: 0.937
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84887442981&partnerID=40&md5=6c4df52ecbe240037dcf1cc52e9f556f
Keywords: Bifunctional Chelating Agent, Biological Probe, Dota, Peptide Labeling, 10 Tetraazacyclododecane 1, 7 Tris(acetic Acid) 10 Butyrate Mono(n Hydroxysuccinimidyl Ester), Immunoglobulin F(ab) Fragment, Tetraxetan, Unclassified Drug, Amino Acid Sequence, Article, Chemical Labeling, Chemical Reaction, Drug Synthesis, High Performance Liquid Chromatography, Molecular Probe, Physical Chemistry, Protein Binding, Proton Nuclear Magnetic Resonance, Reaction Analysis, 7 Tris (acetic Acid) 10 Butyrate Mono (n Hydroxysuccinimidyl Ester), Immunoglobulin F (ab) Fragment,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council, Via Mezzocannone 16, 80138 Naples, Italy
References:
Not available.
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.825, 5-year impact factor: 0.937
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84887442981&partnerID=40&md5=6c4df52ecbe240037dcf1cc52e9f556f
Keywords: Bifunctional Chelating Agent, Biological Probe, Dota, Peptide Labeling, 10 Tetraazacyclododecane 1, 7 Tris(acetic Acid) 10 Butyrate Mono(n Hydroxysuccinimidyl Ester), Immunoglobulin F(ab) Fragment, Tetraxetan, Unclassified Drug, Amino Acid Sequence, Article, Chemical Labeling, Chemical Reaction, Drug Synthesis, High Performance Liquid Chromatography, Molecular Probe, Physical Chemistry, Protein Binding, Proton Nuclear Magnetic Resonance, Reaction Analysis, 7 Tris (acetic Acid) 10 Butyrate Mono (n Hydroxysuccinimidyl Ester), Immunoglobulin F (ab) Fragment,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council, Via Mezzocannone 16, 80138 Naples, Italy
References:
Not available.
Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes
Due to the continued interest in new bifunctional chelating agents (BFCA), we focused on the development of a convenient synthesis of 1,4,7,10- tetraazacyclododecane-1,4,7-tris(acetic acid)-10-butyrate mono (N-hydroxysuccinimidyl ester). It consists in the macrocycle DO3A derivatized with an aliphatic linker containing an active ester that requires selective and mild conditions to react with the targeting biomolecule. It is important to underlay the versatility of the obtained BFCA, which can be conjugated both to a biomolecule (protein, Fab fragment) or to a synthetic molecule. In a subsequent step, the developed chelator was successfully conjugated to a peptide sequence. © 2013 Springer Science+Business Media New York.
Due to the continued interest in new bifunctional chelating agents (BFCA), we focused on the development of a convenient synthesis of 1,4,7,10- tetraazacyclododecane-1,4,7-tris(acetic acid)-10-butyrate mono (N-hydroxysuccinimidyl ester). It consists in the macrocycle DO3A derivatized with an aliphatic linker containing an active ester that requires selective and mild conditions to react with the targeting biomolecule. It is important to underlay the versatility of the obtained BFCA, which can be conjugated both to a biomolecule (protein, Fab fragment) or to a synthetic molecule. In a subsequent step, the developed chelator was successfully conjugated to a peptide sequence. © 2013 Springer Science+Business Media New York.
Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes
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Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes
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12 Records (12 excluding Abstracts).
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Total 5 year impact factor: 32.379 (32.379 excluding Abstracts).
Total impact factor: 30.549 (30.549 excluding Abstracts).
Total 5 year impact factor: 32.379 (32.379 excluding Abstracts).
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