Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling
Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling(794 views) Monfregola L, Saviano M, De Luca S
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
Keywords: αvβ 3 Receptor, Selective Radioactive Probe, Solid Phase Synthesis, Diagnostic Agent, Indium Arginylglycylaspartic Acid Pentetic Acid Conjugate In 111, Lysine, Metal, Unclassified Drug, Vitronectin Receptor, Animal Experiment, Animal Tissue, Cell Adhesion, Conjugation, Controlled Study, Covalent Bond, Drug Structure, Drug Synthesis, In Vitro Study, In Vivo Study, Isotope Labeling, Isotope Tracing, Molecular Model, Mouse, Nonhuman, Protein Analysis, Protein Interaction, Protein Synthesis, Purification, V 3 Receptor
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini IBB, CNR, Naples 80134, Italy
References: Not available.
Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling
Small radiolabelled compounds such as peptides are very attractive tools for the diagnosis of several different pathologies (Heppeler in Curr Med Chem 7:971-994, 2000). Among the possible biological targets for radiolabelled compounds, the alpha(v)beta(3) (alpha(v)beta(3)) integrin cell adhesion receptor has been extensively studied. It is expressed on proliferating but not quiescent endothelial cells and has been shown to be involved in tumour progression, angiogenesis and metastasis. The novel radioactive probe (111)In-DTPA-RGDechi has been successfully employed for selective alpha(v)beta(3) single-photon imaging studies. Herein we report the efficient synthetic protocol developed in order to obtain the conjugate diethylentriaminopentacetic acid (DTPA)-RGDechi in good yield and high purity.
Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling
Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling
Vitiello M, Finamore E, Falanga A, Raieta K, Cantisani M, Galdiero F, Pedone C, Galdiero M, Galdiero S * Fusion in Coq(765 views) Lecture Notes In Computer Science (ISSN: 0302-9743, 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2001; 2178LNCS: 583-596. Impact Factor:0.415 ViewExport to BibTeXExport to EndNote