Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.652, 5-year impact factor: 1.715
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-2342606502&partnerID=40&md5=e924c10a34512402c285103d9f412bf1
Keywords: Cck8 Analogues, Cck8 Chelating Derivative, Solid-Phase Synthesis, Sulfated Peptides, Chelating Agent, Cholecystokinin Octapeptide Derivative, Cyclopeptide, Glutamic Acid, Indium 111, Lysine, Metal, Pentetic Acid, Pyridine Derivative, Radioisotope, Tyrosine, Acidity, Article, Chemical Reaction, Chemical Structure, Controlled Study, Covalent Bond, Isotope Labeling, Methodology, Peptide Analysis, Peptide Synthesis, Priority Journal, Protein Stability, Proton Nuclear Magnetic Resonance, Receptor Binding, Sulfation, Humans, Indium Radioisotopes, Molecular Structure, Protein Binding, Sulfuric Acid Esters,
Affiliations:
*** IBB - CNR ***
CIRPeB, Dipartimento Chimica Biologica, Universita di Napoli Federico II, Via Mezzocannone 6-8, 80134 Napoli, Italy
References:
Heppeler, A., Froidevaux, S., Eberle, A.N., Maecke, H.R., Receptor targeting for tumor localisation and therapy with radiopeptides (2000) Curr. Med. Chem., 7, pp. 971-99
Reubi, J.C., Schaer, J.C., Waser, B., Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Kennedy, K., Gigoux, V., Escrieut, C., Maigret, B., Martinez, J., Moroder, L., Frehel, D., Fourmy, D., Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin (1997) J. Biol. Chem., 272, pp. 2920-2926
Ji, Z., Hadak, E.M., Henne, R.M., Patel, S.A., Lybrand, T.P., Miller, L.J., Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling (1997) J. Biol. Chem., 272, pp. 24393-24401
Ragone, R., DeLuca, S., Tesauro, D., Pedone, C., Morelli, G., Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (2001) Biopolymers, 56, pp. 47-53
Mierke, D.F., Pellegrini, M., Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy (1999) Biochemistry, 38, pp. 14775-14783
Giragossian, C., Mierke, D.F., Intermolecular interactions between cholecystokinin-8 and third extracellular loop of cholecystokinin A receptor (2001) Biochemistry, 40, pp. 3804-3809
De Luca, S., Ragone, R., Bracco, C., Digilio, G., Aloj, L., Tesauro, D., Saviano, M., Morelli, G., A cyclic CCK8 analog selective for the cholecystokinin type A receptor: Design, synthesis, NMR structure and binding measurements (2003) ChemBioChem, , in press
Aloj, L., Caracò, C., Zannetti, C., Del Vecchio, S., Tesauro, D., De Luca, S., Panico, M.R., Salvatore, M., Characterization of 111In labeled CCK8 peptide conjugated to a DTPA derivative (DTPA-Glu) in CCK-B receptor overexpressing cells and xenografts (2003) J. Nucl. Med., , submitted
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of biologically DTPA-like ligands (1999) Bioconjugate Chem., 10, pp. 137-140
Sarin, V.K., Kent, S.B., Tam, J.P., Merrifield, R.B., Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction (1981) Anal. Biochem., 117, pp. 147-157
Kitagawa, K., Aida, C., Fujiwara, H., Yagami, T., Futaki, S., Kogire, M., Ida, J., Inoue, K., Facile solid-phase synthesis of sulphated tyrosine-containing peptides: Total synthesis of human big gastrin-II cholecystokinin (CCK)-39 (2001) J. Org. Chem., 66, pp. 1-10
Yagami, T., Kitagawa, K., Aida, C., Fujiwara, H., Futaki, S., Stabilization of a tyrosine O-sulfate residue by a cationic functional group: Formation of a conjugate acid-base pair (2000) J. Peptide Res., 56, pp. 239-249
Reubi, J. C., Schaer, J. C., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Ji, Z., Hadak, E. M., Henne, R. M., Patel, S. A., Lybrand, T. P., Miller, L. J., Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling (1997) J. Biol. Chem., 272, pp. 24393-24401
Mierke, D. F., Pellegrini, M., Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy (1999) Biochemistry, 38, pp. 14775-14783
Aloj, L., Carac, C., Zannetti, C., Del Vecchio, S., Tesauro, D., De Luca, S., Panico, M. R., Salvatore, M., Characterization of 111In labeled CCK8 peptide conjugated to a DTPA derivative (DTPA-Glu) in CCK-B receptor overexpressing cells and xenografts (2003) J. Nucl. Med., , submitted
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of biologically DTPA-like ligands (1999) Bioconjugate Chem., 10, pp. 137-140
Sarin, V. K., Kent, S. B., Tam, J. P., Merrifield, R. B., Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction (1981) Anal. Biochem., 117, pp. 147-157
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.652, 5-year impact factor: 1.715
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-2342606502&partnerID=40&md5=e924c10a34512402c285103d9f412bf1
Keywords: Cck8 Analogues, Cck8 Chelating Derivative, Solid-Phase Synthesis, Sulfated Peptides, Chelating Agent, Cholecystokinin Octapeptide Derivative, Cyclopeptide, Glutamic Acid, Indium 111, Lysine, Metal, Pentetic Acid, Pyridine Derivative, Radioisotope, Tyrosine, Acidity, Article, Chemical Reaction, Chemical Structure, Controlled Study, Covalent Bond, Isotope Labeling, Methodology, Peptide Analysis, Peptide Synthesis, Priority Journal, Protein Stability, Proton Nuclear Magnetic Resonance, Receptor Binding, Sulfation, Humans, Indium Radioisotopes, Molecular Structure, Protein Binding, Sulfuric Acid Esters,
Affiliations:
*** IBB - CNR ***
CIRPeB, Dipartimento Chimica Biologica, Universita di Napoli Federico II, Via Mezzocannone 6-8, 80134 Napoli, Italy
References:
Heppeler, A., Froidevaux, S., Eberle, A.N., Maecke, H.R., Receptor targeting for tumor localisation and therapy with radiopeptides (2000) Curr. Med. Chem., 7, pp. 971-99
Reubi, J.C., Schaer, J.C., Waser, B., Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Kennedy, K., Gigoux, V., Escrieut, C., Maigret, B., Martinez, J., Moroder, L., Frehel, D., Fourmy, D., Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin (1997) J. Biol. Chem., 272, pp. 2920-2926
Ji, Z., Hadak, E.M., Henne, R.M., Patel, S.A., Lybrand, T.P., Miller, L.J., Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling (1997) J. Biol. Chem., 272, pp. 24393-24401
Ragone, R., DeLuca, S., Tesauro, D., Pedone, C., Morelli, G., Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 (2001) Biopolymers, 56, pp. 47-53
Mierke, D.F., Pellegrini, M., Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy (1999) Biochemistry, 38, pp. 14775-14783
Giragossian, C., Mierke, D.F., Intermolecular interactions between cholecystokinin-8 and third extracellular loop of cholecystokinin A receptor (2001) Biochemistry, 40, pp. 3804-3809
De Luca, S., Ragone, R., Bracco, C., Digilio, G., Aloj, L., Tesauro, D., Saviano, M., Morelli, G., A cyclic CCK8 analog selective for the cholecystokinin type A receptor: Design, synthesis, NMR structure and binding measurements (2003) ChemBioChem, , in press
Aloj, L., Caracò, C., Zannetti, C., Del Vecchio, S., Tesauro, D., De Luca, S., Panico, M.R., Salvatore, M., Characterization of 111In labeled CCK8 peptide conjugated to a DTPA derivative (DTPA-Glu) in CCK-B receptor overexpressing cells and xenografts (2003) J. Nucl. Med., , submitted
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of biologically DTPA-like ligands (1999) Bioconjugate Chem., 10, pp. 137-140
Sarin, V.K., Kent, S.B., Tam, J.P., Merrifield, R.B., Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction (1981) Anal. Biochem., 117, pp. 147-157
Kitagawa, K., Aida, C., Fujiwara, H., Yagami, T., Futaki, S., Kogire, M., Ida, J., Inoue, K., Facile solid-phase synthesis of sulphated tyrosine-containing peptides: Total synthesis of human big gastrin-II cholecystokinin (CCK)-39 (2001) J. Org. Chem., 66, pp. 1-10
Yagami, T., Kitagawa, K., Aida, C., Fujiwara, H., Futaki, S., Stabilization of a tyrosine O-sulfate residue by a cationic functional group: Formation of a conjugate acid-base pair (2000) J. Peptide Res., 56, pp. 239-249
Reubi, J. C., Schaer, J. C., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Ji, Z., Hadak, E. M., Henne, R. M., Patel, S. A., Lybrand, T. P., Miller, L. J., Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling (1997) J. Biol. Chem., 272, pp. 24393-24401
Mierke, D. F., Pellegrini, M., Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy (1999) Biochemistry, 38, pp. 14775-14783
Aloj, L., Carac, C., Zannetti, C., Del Vecchio, S., Tesauro, D., De Luca, S., Panico, M. R., Salvatore, M., Characterization of 111In labeled CCK8 peptide conjugated to a DTPA derivative (DTPA-Glu) in CCK-B receptor overexpressing cells and xenografts (2003) J. Nucl. Med., , submitted
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of biologically DTPA-like ligands (1999) Bioconjugate Chem., 10, pp. 137-140
Sarin, V. K., Kent, S. B., Tam, J. P., Merrifield, R. B., Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction (1981) Anal. Biochem., 117, pp. 147-157
Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling
Two cyclic peptides, cyclo29,34[Dpr29, Lys34(DTPA-Glu)]-CCK8 (1) and cyclo29,34[Tyr27(SO3H), Dpr29, Lys34 (DTPA-Glu)]-CCK8 (2), bearing the chelating moiety DTPA-Glu covalently bound to the Lys side chain have been synthesized by solid-phase methodology. The presence in compound 2 of many acidic functions characteristic of the chelating agent increases the lability of the sulfate group on the Tyr side chain. This finding suggests that prolonged acid treatments should be avoided during the preparation of such peptides. Sulfation of cyclo29,34[Dpr29, Lys34 (DTPA-Glu ]-CCK8 was performed using a pyridine-SO3 complex as reagent. This reaction has been found to be the most suitable synthetic strategy for obtaining compound 2 in good yield. Cyclo29,34[Tyr27(SO3H), Dpr29, Lys34(DTPA-Glu)]-CCK8 is a new promising CCK8 analogue, able to coordinate radioactive isotopes of metal ions such as 111In(III), and to bind, in a selective way, the CCKA-R receptor. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.
Two cyclic peptides, cyclo29,34[Dpr29, Lys34(DTPA-Glu)]-CCK8 (1) and cyclo29,34[Tyr27(SO3H), Dpr29, Lys34 (DTPA-Glu)]-CCK8 (2), bearing the chelating moiety DTPA-Glu covalently bound to the Lys side chain have been synthesized by solid-phase methodology. The presence in compound 2 of many acidic functions characteristic of the chelating agent increases the lability of the sulfate group on the Tyr side chain. This finding suggests that prolonged acid treatments should be avoided during the preparation of such peptides. Sulfation of cyclo29,34[Dpr29, Lys34 (DTPA-Glu ]-CCK8 was performed using a pyridine-SO3 complex as reagent. This reaction has been found to be the most suitable synthetic strategy for obtaining compound 2 in good yield. Cyclo29,34[Tyr27(SO3H), Dpr29, Lys34(DTPA-Glu)]-CCK8 is a new promising CCK8 analogue, able to coordinate radioactive isotopes of metal ions such as 111In(III), and to bind, in a selective way, the CCKA-R receptor. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.
Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling
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Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling
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* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (853 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Caporale A, Doti N, Sandomenico A, Ruvo M
* Evaluation of combined use of Oxyma and HATU in aggregating peptide sequences (425 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2017 Apr; 23(4): 272-281.
Impact Factor: 1.969
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (1304 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2017 Mar 16; 18(6): 527-538.
Impact Factor: 2.774
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Calce E, De Luca S
* The Cysteine S-Alkylation Reaction as a Synthetic Method to Covalently Modify Peptide Sequences (400 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Aug 19; 22: 1-11.
Impact Factor: 5.317
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Barresi V, Spampinato G, Musso N, Trovato Salinaro A, Rizzarelli E, Condorelli DF
* ATOX1 gene silencing increases susceptibility to anticancer therapy based on copper ionophores or chelating drugs (724 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 156: 145-152.
Impact Factor: 3.348
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Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (490 views)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
Impact Factor: 6.732
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Romanucci V, Milardi D, Campagna T, Gaglione M, Messere A, D'Urso A, Crisafi E, La Rosa C, Zarrelli A, Balzarini J, Di Fabio G
* Synthesis, biophysical characterization and anti-HIV activity of d(TG(3)AG) Quadruplexes bearing hydrophobic tails at the 5 '-end (365 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 960-966.
Impact Factor: 2.793
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (635 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Calce E, Monfregola L, De Luca S
* Synthetic Strategy to Prepare DOTA-Based Bifunctional Chelating Agent Ready to Bind Biomolecular Probes (466 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2013 Sep; 19(3): 199-202.
Impact Factor: 0.825
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Gringeri CV, Menchise V, Rizzitelli S, Cittadino E, Catanzaro V, Dati G, Chaabane L, Digilio G, Aime S
* Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases (503 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2012 Mar; 7(2): 175-184.
Impact Factor: 2.872
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Di Fiore A, Maresca A, Supuran CT, De Simone G
* Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors (361 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012; 48(70): 8838-8840.
Impact Factor: 6.378
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (409 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Lanza V, Bellia F, D'Agata R, Grasso G, Rizzarelli E, Vecchio G
* New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes (404 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2011 Feb; 105(2): 181-188.
Impact Factor: 3.354
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Pérez de Vega MJ, García-López MT, Zaccaro L, Royo M, Albericio F, Fernández-Carvajal A, Ferrer-Montiel A, González-Muñiz R
* Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers (517 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2010 Jul 15; 15(7): 4924-4933.
Impact Factor: 1.988
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Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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Accardo A, Mansi R, Morisco A, Mangiapia G, Paduano L, Tesauro D, Radulescu A, Aurilio M, Aloj L, Arra C, Morelli G
* Peptide modified nanocarriers for selective targeting of bombesin receptors (429 views)
Mol Biosyst (ISSN: 1742-206x), 2010 May; 6(5): 878-887.
Impact Factor: 3.825
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (534 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (429 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (721 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (421 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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De Luca S, Ulhaq S, Dixon M J, EssexJ, Bradley M
* Solid-phase synthesis of a focused library of trypanothione reductase inhibitors (376 views)
Tetrahedron Lett (ISSN: 0040-4039), 2003 Apr 7; 44(15): 3195-3197.
Impact Factor: 2.326
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (325 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (417 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
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31 Records (28 excluding Abstracts).
Total impact factor: 100.259 (87.602 excluding Abstracts).
Total 5 year impact factor: 102.018 (88.84 excluding Abstracts).
Total impact factor: 100.259 (87.602 excluding Abstracts).
Total 5 year impact factor: 102.018 (88.84 excluding Abstracts).
395 views. Last view on Tuesday 28 February 2023, 8:32:43
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